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Aliases for MAP3K19 Gene

Aliases for MAP3K19 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 19 2 3 5
  • SPS1/STE20-Related Protein Kinase YSK4 3 4
  • Regulated In COPD, Protein Kinase 3 4
  • YSK4 3 4
  • RCK 3 4
  • YSK4 Sps1/Ste20-Related Kinase Homolog (S. Cerevisiae) 2
  • Yeast Sps1/Ste20-Related Kinase 4 (S. Cerevisiae) 2
  • YSK4 Sps1/Ste20-Related Kinase Homolog 3
  • Yeast Sps1/Ste20-Related Kinase 4 3
  • Regulated In COPD Kinase 3
  • EC 4

External Ids for MAP3K19 Gene

Previous HGNC Symbols for MAP3K19 Gene

  • YSK4

Previous GeneCards Identifiers for MAP3K19 Gene

  • GC02M135723

Summaries for MAP3K19 Gene

GeneCards Summary for MAP3K19 Gene

MAP3K19 (Mitogen-Activated Protein Kinase Kinase Kinase 19) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K1.

Additional gene information for MAP3K19 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K19 Gene

Genomics for MAP3K19 Gene

Regulatory Elements for MAP3K19 Gene

Enhancers for MAP3K19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H135149 0.9 ENCODE 29 -104.0 -104019 3 FOXA2 ARID4B YBX1 ZSCAN9 RARA FOS THAP11 SP5 CEBPB KAT8 MAP3K19 RAB3GAP1 GC02M135137 PIR52405
GH02H135051 1.1 ENCODE 18.4 -6.1 -6128 3.8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 MAP3K19 DARS ZRANB3 RAB3GAP1 GC02P135138
GH02H135073 0.6 ENCODE 29.4 -26.9 -26913 1.2 ZNF217 SMARCE1 PKNOX1 ZNF687 HNF4A KLF4 DPF2 MAP3K19 ZRANB3 RAB3GAP1 GC02P135138
GH02H135164 0.6 ENCODE 28.7 -117.2 -117191 1.1 PKNOX1 MNT RAD21 GATA3 CTBP1 CUX1 FOS FOSL2 MAP3K19 SNORA40B RAB3GAP1 PIR52405 GC02M135137
GH02H135529 1.1 ENCODE 15.1 -483.7 -483745 4.4 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 ZNF143 FOS UBXN4 MCM6 CCNT2 MAP3K19 ZRANB3 LOC100422338
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAP3K19 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MAP3K19 Gene

Genomic Locations for MAP3K19 Gene
83,179 bases
Minus strand

Genomic View for MAP3K19 Gene

Genes around MAP3K19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K19 Gene

Proteins for MAP3K19 Gene

  • Protein details for MAP3K19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 19
    Protein Accession:
    Secondary Accessions:
    • B2RP57
    • B7ZMH9
    • E2QRE3
    • Q56UN1
    • Q56UN2
    • Q56UN3
    • Q56UN4
    • Q8N4E9
    • Q9H5T2

    Protein attributes for MAP3K19 Gene

    1328 amino acids
    Molecular mass:
    150537 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MAP3K19 Gene

neXtProt entry for MAP3K19 Gene

Post-translational modifications for MAP3K19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAP3K19 Gene

Domains & Families for MAP3K19 Gene

Gene Families for MAP3K19 Gene

Protein Domains for MAP3K19 Gene

Suggested Antigen Peptide Sequences for MAP3K19 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with MAP3K19: view

Function for MAP3K19 Gene

Molecular function for MAP3K19 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for MAP3K19 Gene

Phenotypes From GWAS Catalog for MAP3K19 Gene

Gene Ontology (GO) - Molecular Function for MAP3K19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with MAP3K19: view
genes like me logo Genes that share phenotypes with MAP3K19: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAP3K19 Gene

Localization for MAP3K19 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K19 gene
Compartment Confidence
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MAP3K19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with MAP3K19: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP3K19 Gene

Pathways & Interactions for MAP3K19 Gene

SuperPathways for MAP3K19 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAP3K19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007346 regulation of mitotic cell cycle IBA --
GO:0016310 phosphorylation IEA --
GO:0023014 signal transduction by protein phosphorylation IBA --
GO:0031098 stress-activated protein kinase signaling cascade IBA --
genes like me logo Genes that share ontologies with MAP3K19: view

No data available for Pathways by source and SIGNOR curated interactions for MAP3K19 Gene

Drugs & Compounds for MAP3K19 Gene

No Compound Related Data Available

Transcripts for MAP3K19 Gene

Unigene Clusters for MAP3K19 Gene

Mitogen-activated protein kinase kinase kinase 19:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K19 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e
SP1: -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - -

Relevant External Links for MAP3K19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP3K19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP3K19 Gene

mRNA differential expression in normal tissues according to GTEx for MAP3K19 Gene

This gene is overexpressed in Testis (x18.6), Brain - Hypothalamus (x6.5), Brain - Caudate (basal ganglia) (x4.6), and Fallopian Tube (x4.5).

Protein differential expression in normal tissues from HIPED for MAP3K19 Gene

This gene is overexpressed in Heart (54.3) and Brain (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAP3K19 Gene

Protein tissue co-expression partners for MAP3K19 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAP3K19 Gene:


SOURCE GeneReport for Unigene cluster for MAP3K19 Gene:


Evidence on tissue expression from TISSUES for MAP3K19 Gene

  • Lung(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with MAP3K19: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K19 Gene

Orthologs for MAP3K19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP3K19 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia YSK4 33
  • 99.02 (n)
MAP3K19 34
  • 98 (a)
(Canis familiaris)
Mammalia MAP3K19 33 34
  • 84.63 (n)
(Bos Taurus)
Mammalia YSK4 33
  • 83.79 (n)
MAP3K19 34
  • 73 (a)
(Mus musculus)
Mammalia Map3k19 33 16 34
  • 73.8 (n)
(Rattus norvegicus)
Mammalia Map3k19 33
  • 71.86 (n)
(Ornithorhynchus anatinus)
Mammalia MAP3K19 34
  • 61 (a)
(Monodelphis domestica)
Mammalia MAP3K19 34
  • 47 (a)
(Gallus gallus)
Aves YSK4 33
  • 59.97 (n)
MAP3K19 34
  • 41 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 27 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15442 33
(Danio rerio)
Actinopterygii map3k19 34
  • 67 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE11 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
Species where no ortholog for MAP3K19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP3K19 Gene

Gene Tree for MAP3K19 (if available)
Gene Tree for MAP3K19 (if available)

Paralogs for MAP3K19 Gene

Paralogs for MAP3K19 Gene

genes like me logo Genes that share paralogs with MAP3K19: view

Variants for MAP3K19 Gene

Sequence variations from dbSNP and Humsavar for MAP3K19 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_041334 A breast pleomorphic lobular carcinoma sample
rs1000008647 -- 135,047,288(+) GGGAC(A/G)GCTGT utr-variant-5-prime
rs1000065951 -- 134,994,519(+) TGGGA(G/T)CAGAA intron-variant
rs1000079510 -- 135,039,402(+) ACATG(C/G)TGAAA intron-variant
rs1000102849 -- 135,049,151(+) GGTGT(G/T)GTGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAP3K19 Gene

Variant ID Type Subtype PubMed ID
esv3560186 CNV deletion 23714750
esv3592568 CNV loss 21293372
nsv961516 CNV duplication 23825009

Variation tolerance for MAP3K19 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.94; 91.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP3K19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K19 Gene

Disorders for MAP3K19 Gene

Relevant External Links for MAP3K19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MAP3K19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K19 Gene

Publications for MAP3K19 Gene

  1. MAP3K19 Is a Novel Regulator of TGF-β Signaling That Impacts Bleomycin-Induced Lung Injury and Pulmonary Fibrosis. (PMID: 27144281) Boehme SA … Bacon KB (PloS one 2016) 2 3 60
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. MAP3K19 Is Overexpressed in COPD and Is a Central Mediator of Cigarette Smoke-Induced Pulmonary Inflammation and Lower Airway Destruction. (PMID: 27935962) Boehme SA … Bacon KB (PloS one 2016) 3 60

Products for MAP3K19 Gene

Sources for MAP3K19 Gene

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