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Aliases for MAP3K19 Gene

Aliases for MAP3K19 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 19 2 3 5
  • SPS1/STE20-Related Protein Kinase YSK4 3 4
  • Regulated In COPD, Protein Kinase 3 4
  • YSK4 3 4
  • RCK 3 4
  • YSK4 Sps1/Ste20-Related Kinase Homolog (S. Cerevisiae) 2
  • Yeast Sps1/Ste20-Related Kinase 4 (S. Cerevisiae) 2
  • YSK4 Sps1/Ste20-Related Kinase Homolog 3
  • Yeast Sps1/Ste20-Related Kinase 4 3
  • Regulated In COPD Kinase 3
  • EC 2.7.11.1 4

External Ids for MAP3K19 Gene

Previous HGNC Symbols for MAP3K19 Gene

  • YSK4

Previous GeneCards Identifiers for MAP3K19 Gene

  • GC02M135723

Summaries for MAP3K19 Gene

GeneCards Summary for MAP3K19 Gene

MAP3K19 (Mitogen-Activated Protein Kinase Kinase Kinase 19) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K19 Gene

Genomics for MAP3K19 Gene

Regulatory Elements for MAP3K19 Gene

Enhancers for MAP3K19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G135149 0.9 ENCODE 29 -104.0 -104019 3.0 FOXA2 ARID4B YBX1 ZSCAN9 RARA FOS THAP11 SP5 CEBPB KAT8 MAP3K19 RAB3GAP1 GC02M135137 PIR52405
GH02G135051 1.1 ENCODE 18.4 -6.1 -6128 3.9 HDGF PKNOX1 FOXA2 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 MAP3K19 DARS ZRANB3 RAB3GAP1 GC02P135137
GH02G135226 1.1 ENCODE 18 -179.8 -179752 1.4 HNRNPUL1 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A MAP3K19 CCNT2 MCM6 ENSG00000208308 ZRANB3 PIR56648 GC02M135288
GH02G135164 0.6 ENCODE 28.7 -117.2 -117191 1.1 PKNOX1 MNT MBD2 ZNF316 CTBP1 CUX1 FOS FOSL2 MAFK MAP3K19 ENSG00000208308 RAB3GAP1 PIR52405 GC02M135137
GH02G135529 1.1 ENCODE 15.1 -483.7 -483745 4.4 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 ZNF143 CCNT2 MAP3K19 MCM6 ZRANB3 LOC100422338
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAP3K19 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAP3K19 Gene

Chromosome:
2
Start:
134,964,290 bp from pter
End:
135,047,468 bp from pter
Size:
83,179 bases
Orientation:
Minus strand

Genomic View for MAP3K19 Gene

Genes around MAP3K19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K19 Gene

Proteins for MAP3K19 Gene

  • Protein details for MAP3K19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q56UN5-M3K19_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 19
    Protein Accession:
    Q56UN5
    Secondary Accessions:
    • B2RP57
    • B7ZMH9
    • E2QRE3
    • Q56UN1
    • Q56UN2
    • Q56UN3
    • Q56UN4
    • Q8N4E9
    • Q9H5T2

    Protein attributes for MAP3K19 Gene

    Size:
    1328 amino acids
    Molecular mass:
    150537 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MAP3K19 Gene

neXtProt entry for MAP3K19 Gene

Post-translational modifications for MAP3K19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAP3K19 Gene

Domains & Families for MAP3K19 Gene

Protein Domains for MAP3K19 Gene

Suggested Antigen Peptide Sequences for MAP3K19 Gene

Graphical View of Domain Structure for InterPro Entry

Q56UN5

UniProtKB/Swiss-Prot:

M3K19_HUMAN :
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with MAP3K19: view

Function for MAP3K19 Gene

Molecular function for MAP3K19 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for MAP3K19 Gene

Gene Ontology (GO) - Molecular Function for MAP3K19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with MAP3K19: view
genes like me logo Genes that share phenotypes with MAP3K19: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAP3K19 Gene

Localization for MAP3K19 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K19 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for MAP3K19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with MAP3K19: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP3K19 Gene

Pathways & Interactions for MAP3K19 Gene

SuperPathways for MAP3K19 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAP3K19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0023014 signal transduction by protein phosphorylation IEA --
GO:0030036 actin cytoskeleton organization IBA --
genes like me logo Genes that share ontologies with MAP3K19: view

No data available for Pathways by source and SIGNOR curated interactions for MAP3K19 Gene

Drugs & Compounds for MAP3K19 Gene

No Compound Related Data Available

Transcripts for MAP3K19 Gene

Unigene Clusters for MAP3K19 Gene

Mitogen-activated protein kinase kinase kinase 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K19 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e
SP1: -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - -
SP6:

Relevant External Links for MAP3K19 Gene

GeneLoc Exon Structure for
MAP3K19
ECgene alternative splicing isoforms for
MAP3K19

Expression for MAP3K19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP3K19 Gene

mRNA differential expression in normal tissues according to GTEx for MAP3K19 Gene

This gene is overexpressed in Testis (x18.6), Brain - Hypothalamus (x6.5), Brain - Caudate (basal ganglia) (x4.6), and Fallopian Tube (x4.5).

Protein differential expression in normal tissues from HIPED for MAP3K19 Gene

This gene is overexpressed in Heart (54.3) and Brain (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAP3K19 Gene



Protein tissue co-expression partners for MAP3K19 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAP3K19 Gene:

MAP3K19

SOURCE GeneReport for Unigene cluster for MAP3K19 Gene:

Hs.659395

Evidence on tissue expression from TISSUES for MAP3K19 Gene

  • Lung(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with MAP3K19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP3K19 Gene

Orthologs for MAP3K19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP3K19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia YSK4 34
  • 99.02 (n)
MAP3K19 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP3K19 34 35
  • 84.63 (n)
cow
(Bos Taurus)
Mammalia YSK4 34
  • 83.79 (n)
MAP3K19 35
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map3k19 34 16 35
  • 73.8 (n)
rat
(Rattus norvegicus)
Mammalia Map3k19 34
  • 71.86 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAP3K19 35
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP3K19 35
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves YSK4 34
  • 59.97 (n)
MAP3K19 35
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 27 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.15442 34
zebrafish
(Danio rerio)
Actinopterygii map3k19 35
  • 67 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE11 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToOne
Species where no ortholog for MAP3K19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP3K19 Gene

ENSEMBL:
Gene Tree for MAP3K19 (if available)
TreeFam:
Gene Tree for MAP3K19 (if available)

Paralogs for MAP3K19 Gene

Paralogs for MAP3K19 Gene

genes like me logo Genes that share paralogs with MAP3K19: view

Variants for MAP3K19 Gene

Sequence variations from dbSNP and Humsavar for MAP3K19 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_041334 A breast pleomorphic lobular carcinoma sample
rs1000008647 -- 135,047,288(+) GGGAC(A/G)GCTGT utr-variant-5-prime
rs1000065951 -- 134,994,519(+) TGGGA(G/T)CAGAA intron-variant
rs1000079510 -- 135,039,402(+) ACATG(C/G)TGAAA intron-variant
rs1000102849 -- 135,049,151(+) GGTGT(G/T)GTGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAP3K19 Gene

Variant ID Type Subtype PubMed ID
esv3560186 CNV deletion 23714750
esv3592568 CNV loss 21293372
nsv961516 CNV duplication 23825009

Variation tolerance for MAP3K19 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.94; 91.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP3K19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP3K19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K19 Gene

Disorders for MAP3K19 Gene

Relevant External Links for MAP3K19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP3K19

No disorders were found for MAP3K19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K19 Gene

Publications for MAP3K19 Gene

  1. MAP3K19 Is a Novel Regulator of TGF-I^ Signaling That Impacts Bleomycin-Induced Lung Injury and Pulmonary Fibrosis. (PMID: 27144281) Boehme S.A. … Bacon K.B. (PLoS ONE 2016) 2 3 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3 64

Products for MAP3K19 Gene

Sources for MAP3K19 Gene

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