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Aliases for MAP3K19 Gene

Aliases for MAP3K19 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 19 2 3
  • SPS1/STE20-Related Protein Kinase YSK4 3 4
  • Regulated In COPD, Protein Kinase 3 4
  • YSK4 3 4
  • RCK 3 4
  • YSK4 Sps1/Ste20-Related Kinase Homolog (S. Cerevisiae) 2
  • Yeast Sps1/Ste20-Related Kinase 4 (S. Cerevisiae) 2
  • YSK4 Sps1/Ste20-Related Kinase Homolog 3
  • Yeast Sps1/Ste20-Related Kinase 4 3
  • Regulated In COPD Kinase 3
  • EC 2.7.11.1 4

External Ids for MAP3K19 Gene

Previous Symbols for MAP3K19 Gene

  • YSK4

Summaries for MAP3K19 Gene

GeneCards Summary for MAP3K19 Gene

MAP3K19 (Mitogen-Activated Protein Kinase Kinase Kinase 19) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is MAP3K5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K19 Gene

Genomics for MAP3K19 Gene

Genomic Location for MAP3K19 Gene

Start:
134,964,491 bp from pter
End:
135,047,468 bp from pter
Size:
82,978 bases
Orientation:
Minus strand

Genomic View for MAP3K19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP3K19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K19 Gene

No data available for Regulatory Elements for MAP3K19 Gene

Proteins for MAP3K19 Gene

  • Protein details for MAP3K19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q56UN5-M3K19_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 19
    Protein Accession:
    Q56UN5
    Secondary Accessions:
    • B2RP57
    • B7ZMH9
    • E2QRE3
    • Q56UN1
    • Q56UN2
    • Q56UN3
    • Q56UN4
    • Q8N4E9
    • Q9H5T2

    Protein attributes for MAP3K19 Gene

    Size:
    1328 amino acids
    Molecular mass:
    150537 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MAP3K19 Gene

neXtProt entry for MAP3K19 Gene

Proteomics data for MAP3K19 Gene at MOPED

Post-translational modifications for MAP3K19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAP3K19 Gene

Domains for MAP3K19 Gene

Gene Families for MAP3K19 Gene

HGNC:
  • MAP3K :Mitogen-activated protein kinase cascade / Kinase kinase kinases
IUPHAR :

UniProtKB/Swiss-Prot:

M3K19_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q56UN5
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.:
    • Q56UN5
genes like me logo Genes that share domains with MAP3K19: view

Function for MAP3K19 Gene

Molecular function for MAP3K19 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for MAP3K19 Gene

Gene Ontology (GO) - Molecular Function for MAP3K19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004709 MAP kinase kinase kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MAP3K19: view

Phenotypes for MAP3K19 Gene

GenomeRNAi human phenotypes for MAP3K19:
genes like me logo Genes that share phenotypes with MAP3K19: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MAP3K19 Gene

Localization for MAP3K19 Gene

Gene Ontology (GO) - Cellular Components for MAP3K19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with MAP3K19: view

Pathways for MAP3K19 Gene

SuperPathways for MAP3K19 Gene

No Data Available

Interacting Proteins for MAP3K19 Gene

Gene Ontology (GO) - Biological Process for MAP3K19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IBA --
GO:0000186 activation of MAPKK activity IBA --
GO:0006468 protein phosphorylation IEA --
GO:0030036 actin cytoskeleton organization IBA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with MAP3K19: view

No data available for Pathways by source for MAP3K19 Gene

Transcripts for MAP3K19 Gene

Unigene Clusters for MAP3K19 Gene

Mitogen-activated protein kinase kinase kinase 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K19 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e
SP1: -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - -
SP6:

Relevant External Links for MAP3K19 Gene

GeneLoc Exon Structure for
MAP3K19
ECgene alternative splicing isoforms for
MAP3K19

Expression for MAP3K19 Gene

mRNA expression in normal human tissues for MAP3K19 Gene

mRNA differential expression in normal tissues according to GTEx for MAP3K19 Gene

This gene is overexpressed in Testis (18.6), Brain - Hypothalamus (6.5), Brain - Caudate (basal ganglia) (4.6), and Fallopian Tube (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MAP3K19 Gene

SOURCE GeneReport for Unigene cluster for MAP3K19 Gene Hs.659395

genes like me logo Genes that share expressions with MAP3K19: view

Orthologs for MAP3K19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP3K19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP3K19 37
  • 98 (a)
OneToOne
YSK4 36
  • 99.02 (n)
  • 98.12 (a)
cow
(Bos Taurus)
Mammalia MAP3K19 37
  • 73 (a)
OneToOne
YSK4 36
  • 83.79 (n)
  • 73.23 (a)
dog
(Canis familiaris)
Mammalia MAP3K19 36
  • 84.63 (n)
  • 74.73 (a)
MAP3K19 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map3k19 36
  • 73.8 (n)
  • 60.71 (a)
Map3k19 16
Map3k19 37
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP3K19 37
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP3K19 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map3k19 36
  • 71.86 (n)
  • 59.34 (a)
chicken
(Gallus gallus)
Aves MAP3K19 37
  • 41 (a)
OneToOne
YSK4 36
  • 59.97 (n)
  • 50.52 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 27 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.15442 36
zebrafish
(Danio rerio)
Actinopterygii map3k19 37
  • 67 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE11 37
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
OneToOne
Species with no ortholog for MAP3K19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP3K19 Gene

ENSEMBL:
Gene Tree for MAP3K19 (if available)
TreeFam:
Gene Tree for MAP3K19 (if available)

Paralogs for MAP3K19 Gene

Paralogs for MAP3K19 Gene

genes like me logo Genes that share paralogs with MAP3K19: view

Variants for MAP3K19 Gene

Sequence variations from dbSNP and Humsavar for MAP3K19 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1592 -- 134,964,573(+) AAACA(A/C)TAGAG utr-variant-3-prime
rs1062084 -- 134,964,760(-) TCCCC(A/C)CTGAA utr-variant-3-prime
rs1112542 - 134,986,846(-) TGCGA(C/G)AGACT missense, reference, intron-variant
rs1530558 -- 134,998,046(+) ACAAG(C/T)AGCAA intron-variant
rs1530559 -- 134,998,059(+) ACAAT(A/G)TTGCC intron-variant

Relevant External Links for MAP3K19 Gene

HapMap Linkage Disequilibrium report
MAP3K19

No data available for Structural Variations from Database of Genomic Variants (DGV) for MAP3K19 Gene

Disorders for MAP3K19 Gene

No disorders were found for MAP3K19 Gene.

No data available for UniProtKB/Swiss-Prot for MAP3K19 Gene

Publications for MAP3K19 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3

Products for MAP3K19 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MAP3K19
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MAP3K19
    • Block miRNA regulation of MAP3K19 using miScript Target Protectors

    Sources for MAP3K19 Gene

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