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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP3K19 Gene

protein-coding   GIFtS: 37
GCID: GC02M135723

Mitogen-Activated Protein Kinase Kinase Kinase 19

(Previous names: Yeast Sps1/Ste20-related kinase 4 (S. cerevisiae), yeast...)
(Previous symbol: YSK4)
  Search for MAP3K19
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 191 2     YSK4 Sps1/Ste20-Related Kinase Homolog (S. Cerevisiae)1
YSK41 2 3     Regulated In COPD Kinase2
Regulated In COPD, Protein Kinase2 3     Yeast Sps1/Ste20-Related Kinase 42
RCK2 3     YSK4 Sps1/Ste20-Related Kinase Homolog2
SPS1/STE20-Related Protein Kinase YSK42 3     EC 2.7.11.13
Yeast Sps1/Ste20-Related Kinase 4 (S. Cerevisiae)1     

External Ids:    HGNC: 262491   Entrez Gene: 801222   Ensembl: ENSG000001766017   UniProtKB: Q56UN53   

Export aliases for MAP3K19 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MAP3K19 Gene: 
MAP3K19 (mitogen-activated protein kinase kinase kinase 19) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and ATP binding. An important paralog of this gene is MAP3K1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022135.16  NC_018913.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MAP3K19
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP3K19 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP3K19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.3   Ensembl cytogenetic band:  2q21.3   HGNC cytogenetic band: 2q21.3

MAP3K19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K19 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M135723:  view genomic region     (about GC identifiers)

Start:
135,722,061 bp from pter      End:
135,805,038 bp from pter
Size:
82,978 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: M3K19_HUMAN, Q56UN5 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 19  
Size: 1328 amino acids; 150537 Da
Secondary accessions: B2RP57 Q56UN1 Q56UN2 Q56UN3 Q56UN4 Q8N4E9 Q9H5T2
Alternative splicing: 6 isoforms:  Q56UN5-1   Q56UN5-2   Q56UN5-3   Q56UN5-4   Q56UN5-5   Q56UN5-6   

Explore the universe of human proteins at neXtProt for MAP3K19: NX_Q56UN5

Explore proteomics data for MAP3K19 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q56UN5

  • MAP3K19 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAP3K19 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001018054.1  NP_001018056.1  NP_001018057.1  NP_001269812.1  NP_079328.3  

    ENSEMBL proteins: 
     ENSP00000365005   ENSP00000351140   ENSP00000365004   ENSP00000376650   ENSP00000376647  
     ENSP00000392827   ENSP00000390940   ENSP00000416345   ENSP00000376649   ENSP00000321160  

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    Novus Biologicals MAP3K19 Protein
    Novus Biologicals MAP3K19 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 


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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MAP3K: Mitogen-activated protein kinase cascade / Kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase 19 
    STE20 family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q56UN5

    ProtoNet protein and cluster: Q56UN5

    UniProtKB/Swiss-Prot: M3K19_HUMAN, Q56UN5
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    MAP3K19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M3K19_HUMAN, Q56UN5
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    MAP3K19 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MAP3K19:
     Decreased substrate adherent c  Wnt reporter downregulated 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAP3K19 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAP3K19

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP3K19 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP3K19 

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    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K19


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAP3K19

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    MAP3K19 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP3K19 (M3K19)

    Search CenterWatch for drugs/clinical trials and news about MAP3K19 / M3K19

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAP3K19 gene (6 alternative transcripts): 
    NM_001018045.1  NM_001018044.2  NM_001018046.2  NM_001018047.2  NM_001282883.1  NM_025052.4  

    Unigene Cluster for MAP3K19:

    Mitogen-activated protein kinase kinase kinase 19
    Hs.659395  [show with all ESTs]
    Unigene Representative Sequence: AK122935
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375845(uc002tue.1 uc002tuf.1 uc010fnc.1 uc010fnd.1 uc010zbg.1)
    ENST00000358371 ENST00000375844 ENST00000392918 ENST00000478805 ENST00000392915(uc002tuh.4 uc002tui.4)
    ENST00000437365 ENST00000468155(uc010fne.1) ENST00000425952 ENST00000414343
    ENST00000486077 ENST00000392917 ENST00000315513
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAP3K19
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MAP3K19
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat MAP3K19
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP3K19
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP3K19

    Additional mRNA sequence: 

    AK122935.1 AK131216.1 AK225579.1 AK309454.1 AY574901.1 AY574902.1 AY574903.1 AY574904.1 
    AY574905.1 BC034417.1 BC137276.1 BC137277.1 BC144555.1 

    9 DOTS entries:

    DT.91917990  DT.403574  DT.121021305  DT.102825058  DT.121021292  DT.99996939  DT.97790639  DT.121021303 
    DT.121021293 

    24/25 AceView cDNA sequences (see all 25):

    AK131216 CA311871 BM969829 BC034417 BQ045211 AK122935 CD632386 N57475 
    AK026727 CD632400 AK097522 CD632385 CD632388 NM_025052 BI832332 N47620 
    CD632394 BX090530 CD632390 CD632402 CD632398 CD632392 CD632396 BU676900 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K19 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e
    SP1:                                                              -                                       
    SP2:        -                                                     -     -                                 
    SP3:        -                                   -           -     -     -     -                           
    SP4:        -                                   -                 -     -                                 
    SP5:        -                 -     -                             -     -                                 


    ECgene alternative splicing isoforms for MAP3K19

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP3K19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MAP3K19 Expression
    About this image


    See MAP3K19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP3K19

    SOURCE GeneReport for Unigene cluster: Hs.659395
        SABiosciences Custom PCR Arrays for MAP3K19
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAP3K19 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map3k195
    Ysk41
    Yeast Sps1/Ste20-related kinase 4 (S. cerevisiae)1, 5 73.76(n)1
    60.75(a)1
      1 (55.80 cM)5
    226251  NM_011737.11  NP_035867.11 
     1278152715 
    chicken
    (Gallus gallus)
    Aves YSK46
    Uncharacterized protein
    40(a)
    1 ↔ 1
    7(29990466-29999593)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.154422 Xenopus laevis transcribed sequence with moderate similarity more 74.84(n)    BJ079840.1 
    zebrafish
    (Danio rerio)
    Actinopterygii map3k196
    zgc:1715166
    zgc:171516
    66(a)
    12(a)
    1 ↔ 1
    possible ortholog
    9(24258106-24267409)
    24(20837692-20928932)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STE116
    BCK16
    Signal transducing MEK kinase involved in pheromon...
    Mitogen-activated protein (MAP) kinase kinase kina...
    22(a)
    16(a)
    many ↔ many
    many ↔ many
    XII(849866-852019)
    X(247255-251691)
    rice
    (Oryza sativa)
    Liliopsida AK103087.12   -- 72.68(n)    AK103087.1 


    ENSEMBL Gene Tree for MAP3K19 (if available)
    TreeFam Gene Tree for MAP3K19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP3K19 gene
    MAP3K12  MAP3K32  MAP3K52  MAP3K152  MAP3K22  MAP3K82  MAP3K62  
    18/20 SIMAP similar genes for MAP3K19 using alignment to 5 protein entries:     M3K19_HUMAN (see all proteins) (see all similar genes):
    YSK4    MST094    MAP3K2    MAP3K6    PAK2    MST4
    NEK7    STK11    STK24    STK25    STK4    NEK6
    HUNK    MAP2K5    MAPK8    PAK4    MYO3A    CDC2

    MAP3K19 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1333 SNPs in MAP3K19 are shown (see all 1333)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0413344
    A breast pleomorphic lobular carcinoma sample4--see VAR_0413342 I M mis40--------
    rs1424279961,2
    --135721803(+) GAAAAA/GAGCCC 2 -- ds50010--------
    rs1147539471,2
    F--135721888(+) AAATGC/ACGAGG 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs793487551,2
    C,F--135722028(+) AAGTAA/CGCATC 2 -- ds50011Minor allele frequency- C:0.03EA 120
    rs1869372741,2
    --135722057(+) AAATAC/TAAGTT 2 -- ds50010--------
    rs37690221,2
    C,F,H--135722098(-) GTCAAT/CTTTAA 2 -- ds50019Minor allele frequency- C:0.21EA NA NS 1420
    rs15921,2
    C,F,O,A,H--135722143(+) AAACAC/ATAGAG 2 -- ds500131Minor allele frequency- A:0.40EA MN NA NS WA CSA 4513
    rs1920811951,2
    --135722227(+) ATACTA/GTGAGT 2 -- ds50010--------
    rs168312151,2
    C,F,H--135722328(+) TTTTCA/GGTGGG 2 -- ut3115Minor allele frequency- G:0.06NA NS EA CSA WA 1454
    rs1831662091,2
    --135722355(+) AGCCAC/TCATTC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for MAP3K19 (135722061 - 135805038 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MAP3K19: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP3K19
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP3K19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP3K19 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MAP3K19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
    6. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80122 HGNC: 26249 AceView: FLJ23074 Ensembl:ENSG00000176601 euGenes: HUgn80122
    ECgene: MAP3K19 H-InvDB: MAP3K19

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP3K19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAP3K19 gene:
    Search GeneIP for patents involving MAP3K19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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