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Aliases for MAP3K19 Gene

Aliases for MAP3K19 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 19 2 3 5
  • SPS1/STE20-Related Protein Kinase YSK4 3 4
  • Regulated In COPD, Protein Kinase 3 4
  • YSK4 3 4
  • RCK 3 4
  • YSK4 Sps1/Ste20-Related Kinase Homolog (S. Cerevisiae) 2
  • Yeast Sps1/Ste20-Related Kinase 4 (S. Cerevisiae) 2
  • YSK4 Sps1/Ste20-Related Kinase Homolog 3
  • Yeast Sps1/Ste20-Related Kinase 4 3
  • Regulated In COPD Kinase 3
  • EC 4

External Ids for MAP3K19 Gene

Previous HGNC Symbols for MAP3K19 Gene

  • YSK4

Previous GeneCards Identifiers for MAP3K19 Gene

  • GC02M135723

Summaries for MAP3K19 Gene

GeneCards Summary for MAP3K19 Gene

MAP3K19 (Mitogen-Activated Protein Kinase Kinase Kinase 19) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K19 Gene

Genomics for MAP3K19 Gene

Regulatory Elements for MAP3K19 Gene

Enhancers for MAP3K19 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAP3K19 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAP3K19 Gene

134,964,290 bp from pter
135,047,468 bp from pter
83,179 bases
Minus strand

Genomic View for MAP3K19 Gene

Genes around MAP3K19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K19 Gene

Proteins for MAP3K19 Gene

  • Protein details for MAP3K19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 19
    Protein Accession:
    Secondary Accessions:
    • B2RP57
    • B7ZMH9
    • E2QRE3
    • Q56UN1
    • Q56UN2
    • Q56UN3
    • Q56UN4
    • Q8N4E9
    • Q9H5T2

    Protein attributes for MAP3K19 Gene

    1328 amino acids
    Molecular mass:
    150537 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MAP3K19 Gene

neXtProt entry for MAP3K19 Gene

Proteomics data for MAP3K19 Gene at MOPED

Post-translational modifications for MAP3K19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAP3K19 Gene

Domains & Families for MAP3K19 Gene

Suggested Antigen Peptide Sequences for MAP3K19 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with MAP3K19: view

Function for MAP3K19 Gene

Molecular function for MAP3K19 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for MAP3K19 Gene

Gene Ontology (GO) - Molecular Function for MAP3K19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MAP3K19: view
genes like me logo Genes that share phenotypes with MAP3K19: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MAP3K19 Gene

Localization for MAP3K19 Gene

Subcellular locations from

Jensen Localization Image for MAP3K19 Gene COMPARTMENTS Subcellular localization image for MAP3K19 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAP3K19 Gene

Pathways & Interactions for MAP3K19 Gene

SuperPathways for MAP3K19 Gene

No Data Available

Interacting Proteins for MAP3K19 Gene

Gene Ontology (GO) - Biological Process for MAP3K19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007346 regulation of mitotic cell cycle IBA --
GO:0031098 stress-activated protein kinase signaling cascade IBA --
GO:0032147 activation of protein kinase activity IBA --
genes like me logo Genes that share ontologies with MAP3K19: view

No data available for Pathways by source and SIGNOR curated interactions for MAP3K19 Gene

Drugs & Compounds for MAP3K19 Gene

No Compound Related Data Available

Transcripts for MAP3K19 Gene

Unigene Clusters for MAP3K19 Gene

Mitogen-activated protein kinase kinase kinase 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K19 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e
SP1: -
SP2: - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - -

Relevant External Links for MAP3K19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP3K19 Gene

mRNA expression in normal human tissues for MAP3K19 Gene

mRNA differential expression in normal tissues according to GTEx for MAP3K19 Gene

This gene is overexpressed in Testis (x18.6), Brain - Hypothalamus (x6.5), Brain - Caudate (basal ganglia) (x4.6), and Fallopian Tube (x4.5).

Protein differential expression in normal tissues from HIPED for MAP3K19 Gene

This gene is overexpressed in Heart (54.3) and Brain (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAP3K19 Gene

SOURCE GeneReport for Unigene cluster for MAP3K19 Gene Hs.659395

genes like me logo Genes that share expression patterns with MAP3K19: view

Protein tissue co-expression partners for MAP3K19 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MAP3K19 Gene

Orthologs for MAP3K19 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP3K19 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia YSK4 35
  • 83.79 (n)
  • 73.23 (a)
MAP3K19 36
  • 73 (a)
(Canis familiaris)
Mammalia MAP3K19 35
  • 84.63 (n)
  • 74.73 (a)
MAP3K19 36
  • 75 (a)
(Mus musculus)
Mammalia Map3k19 35
  • 73.8 (n)
  • 60.71 (a)
Map3k19 16
Map3k19 36
  • 60 (a)
(Pan troglodytes)
Mammalia YSK4 35
  • 99.02 (n)
  • 98.12 (a)
MAP3K19 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Map3k19 35
  • 71.86 (n)
  • 59.34 (a)
(Monodelphis domestica)
Mammalia MAP3K19 36
  • 47 (a)
(Ornithorhynchus anatinus)
Mammalia MAP3K19 36
  • 61 (a)
(Gallus gallus)
Aves YSK4 35
  • 59.97 (n)
  • 50.52 (a)
MAP3K19 36
  • 41 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15442 35
(Danio rerio)
Actinopterygii map3k19 36
  • 67 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE11 36
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for MAP3K19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP3K19 Gene

Gene Tree for MAP3K19 (if available)
Gene Tree for MAP3K19 (if available)

Paralogs for MAP3K19 Gene

Paralogs for MAP3K19 Gene

genes like me logo Genes that share paralogs with MAP3K19: view

Variants for MAP3K19 Gene

Sequence variations from dbSNP and Humsavar for MAP3K19 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_041334 A breast pleomorphic lobular carcinoma sample
rs16831235 - 134,987,559(+) GTACA(A/G)TACAC intron-variant, reference, missense
rs1112542 - 134,986,846(-) TGCGA(C/G)AGACT intron-variant, reference, missense
rs3905317 - 134,986,437(-) TGAAG(A/G)AGTTT intron-variant, reference, missense
rs1551497 -- 135,030,072(-) GTCAC(A/G)CAACA intron-variant

Variation tolerance for MAP3K19 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.94; 91.94% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MAP3K19 Gene

Disorders for MAP3K19 Gene

Relevant External Links for MAP3K19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MAP3K19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K19 Gene

Publications for MAP3K19 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for MAP3K19 Gene

Sources for MAP3K19 Gene