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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP3K15 Gene

protein-coding   GIFtS: 48
GCID: GC0XM019288

Mitogen-Activated Protein Kinase Kinase Kinase 15

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 151 2     MEKK 152 3
ASK32 3 5     EC 2.7.11.253 8
Apoptosis Signal-Regulating Kinase 32 3     bA723P2.32
MAPK/ERK Kinase Kinase 152 3     EC 2.7.118
MEK Kinase 152 3     

External Ids:    HGNC: 316891   Entrez Gene: 3898402   Ensembl: ENSG000001808157   OMIM: 3008205   UniProtKB: Q6ZN163   

Export aliases for MAP3K15 gene to outside databases

Previous GC identifers: GC0XM019138 GC0XM017127


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAP3K15 Gene:
The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family
members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K)
phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K
protein plays an essential role in apoptotic cell death triggered by cellular stresses. (provided by RefSeq, Jul
2010)

GeneCards Summary for MAP3K15 Gene: 
MAP3K15 (mitogen-activated protein kinase kinase kinase 15) is a protein-coding gene. Diseases associated with MAP3K15 include neuronitis. GO annotations related to this gene include MAP kinase kinase kinase activity and metal ion binding. An important paralog of this gene is MAP3K1.

UniProtKB/Swiss-Prot: M3K15_HUMAN, Q6ZN16
Function: May function in a signal transduction pathway that is activated by various cell stresses and leads to
apoptosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_167197.1  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP3K15 gene promoter:
         RP58   AML1a   HTF   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   PPAR-gamma1   STAT3   PPAR-gamma2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP3K15 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP3K15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.12   Ensembl cytogenetic band:  Xp22.12   HGNC cytogenetic band: Xp22.12

MAP3K15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K15 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM019288:  view genomic region     (about GC identifiers)

Start:
19,378,174 bp from pter      End:
19,533,379 bp from pter
Size:
155,206 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: M3K15_HUMAN, Q6ZN16 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 15  
Size: 1313 amino acids; 147437 Da
Cofactor: Magnesium (By similarity)
Secondary accessions: A2AI49 A2AI50 A6NJ61 Q5JPR4 Q6ZMV3
Alternative splicing: 3 isoforms:  Q6ZN16-1   Q6ZN16-2   Q6ZN16-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP3K15: NX_Q6ZN16

Explore proteomics data for MAP3K15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZN16

  • 4/5 DME Specific Peptides for MAP3K15 (Q6ZN16) (see all 5)
     VPGGSLS  NLLLSYRD  LFGFQDAVN  KISDFGTSK 

    MAP3K15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAP3K15 Protein Expression
    REFSEQ proteins: NP_001001671.3  
    ENSEMBL proteins: 
     ENSP00000352093   ENSP00000428356   ENSP00000345629  

    Human Recombinant Protein Products for MAP3K15: 
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    Novus Biologicals MAP3K15 Protein
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    Cloud-Clone Corp. Proteins for MAP3K15 


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    LSBio Antibodies in human, mouse, rat for MAP3K15 

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    Cloud-Clone Corp. ELISAs for MAP3K15 
    Cloud-Clone Corp. CLIAs for MAP3K15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MAP3K: Mitogen-activated protein kinase cascade / Kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase 15 
    STE11 family

    5/7 InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR025136 DUF4071

    Graphical View of Domain Structure for InterPro Entry Q6ZN16

    ProtoNet protein and cluster: Q6ZN16

    UniProtKB/Swiss-Prot: M3K15_HUMAN, Q6ZN16
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain


    MAP3K15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M3K15_HUMAN, Q6ZN16
    Function: May function in a signal transduction pathway that is activated by various cell stresses and leads to
    apoptosis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-812,
    inhibited by phosphorylation at Ser-924 and Ser-994 (By similarity)

         Enzyme Numbers (IUBMB): EC 2.7.11.251 2 EC 2.7.112

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity ----
    GO:0004709MAP kinase kinase kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    MAP3K15 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAP3K15 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP3K15 
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K15


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAP3K15

    1 Interacting protein for MAP3K15 (Q6ZN163) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKAB2O437413I2D: score=3 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    MAP3K15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP3K15 (M3K15)

    1 HMDB Compound for MAP3K15    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    Search CenterWatch for drugs/clinical trials and news about MAP3K15 / M3K15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAP3K15 gene: 
    NM_001001671.3  

    Unigene Cluster for MAP3K15:

    Mitogen-activated protein kinase kinase kinase 15
    Hs.713701  [show with all ESTs]
    Unigene Representative Sequence: AK131477
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000518578(uc004czj.2 uc004czk.2) ENST00000359173 ENST00000470101(uc004czi.2)
    ENST00000469203 ENST00000338883(uc022btq.1)
    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MAP3K15
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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                         Customized lentivirus expression plasmids for stable overexpression of MAP3K15 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MAP3K15
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP3K15
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP3K15

    Additional mRNA sequence: 

    AK122632.1 AK131412.1 AK131477.1 

    8 DOTS entries:

    DT.100809803  DT.95374005  DT.99970178  DT.75100518  DT.91759992  DT.95373992  DT.97760119  DT.99968606 

    24/36 AceView cDNA sequences (see all 36):

    AK122632 BI324992 C21317 CK905334 BM508924 BQ895929 BM996486 AK131412 
    BV180702 AI470129 AI282086 CD511811 CK905335 AA946574 BM505555 AK131477 
    D45559 BU620767 NM_001001671 AI379724 AW995934 BF858163 BX373455 BE834018 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP3K15 expression in normal human tissues (normalized intensities)      MAP3K15 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGCTGGGA
    MAP3K15 Expression
    About this image


    MAP3K15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 4 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord

    See MAP3K15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP3K15

    SOURCE GeneReport for Unigene cluster: Hs.713701

    UniProtKB/Swiss-Prot: M3K15_HUMAN, Q6ZN16
    Tissue specificity: Isoform 2 and isoform 3 are widely expressed. Isoform 2 highest levels are observed in fetal
    brain, and isoform 3 highest levels in pancreas, peripheral blood leukocytes, fetal brain and spleen

        SABiosciences Custom PCR Arrays for MAP3K15
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MAP3K15 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map3k151 , 5 mitogen-activated protein kinase kinase kinase 151, 5 86.33(n)1
    88.54(a)1
      X (73.95 cM)5
    2706721  NM_001163085.21  NP_001156557.21 
     1599884335 
    chicken
    (Gallus gallus)
    Aves MAP3K151 mitogen-activated protein kinase kinase kinase 15 75.22(n)
    81.65(a)
      418609  XM_003640489.1  XP_003640537.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAP3K156
    mitogen-activated protein kinase kinase kinase 15
    80(a)
    1 ↔ 1
    3(123412101-123502948)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003342891 mitogen-activated protein kinase kinase kinase 15-like 70.85(n)
    76.43(a)
      100334289  XM_003201311.1  XP_003201359.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pk92B1 Protein kinase at 92B 52.66(n)
    47.59(a)
      42366  NM_057741.4  NP_477089.3 
    worm
    (Caenorhabditis elegans)
    Secernentea nsy-11 Neuronal Symmetry 47.94(n)
    42.27(a)
      173866  NM_062524.6  NP_494925.2 


    ENSEMBL Gene Tree for MAP3K15 (if available)
    TreeFam Gene Tree for MAP3K15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP3K15 gene
    MAP3K12  MAP3K32  MAP3K52  MAP3K22  MAP3K82  MAP3K192  MAP3K62  
    18/38 SIMAP similar genes for MAP3K15 using alignment to 2 protein entries:     M3K15_HUMAN (see all proteins) (see all similar genes):
    MAP3K5    MAP3K6    MAP3K2    BRAF    MARK4    YSK4
    NEK9    CDK7    MST094    PRKY    STK11    STK25
    RPS6KA2    TXK    CCRK    NEK6    PAK2    PRKACB

    MAP3K15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3046 SNPs in MAP3K15 are shown (see all 3046)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0407224
    A lung adenocarcinoma sample4--see VAR_0407222 S L mis40--------
    VAR_0407194
    A lung squamous cell carcinoma sample4--see VAR_0407192 R S mis40--------
    VAR_0407234
    A metastatic melanoma sample4--see VAR_0407232 R Q mis40--------
    VAR_0407274
    A colorectal adenocarcinoma sample4--see VAR_0407272 W R mis40--------
    VAR_0407184
    ----see VAR_0407182 D H mis40--------
    rs1998798091,2
    C--19291511(+) CCAGCA/GACCCA 1 -- ds50010--------
    rs2011566131,2
    C--19291556(+) AGTTTA/CAGTCA 1 -- ds50010--------
    rs2005475741,2
    --19291585(+) AAGGAC/GAGGTT 1 -- ds50010--------
    rs1473381221,2
    C--19291660(+) TGAAAA/TTCAAT 1 -- ds50010--------
    rs7096101,2
    C,F,O,A,H--19291680(+) GGAAAC/TTTCCA 1 -- ds500115Minor allele frequency- T:0.32MN NS EA WA NA CSA 1838

    HapMap Linkage Disequilibrium report for MAP3K15 (19378174 - 19533379 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MAP3K15:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2740001CNV Deletion23290073
    dgv1395e199CNV Deletion23128226
    esv2740000CNV Deletion23290073
    nsv425077CNV Insertion16902084
    esv23814CNV Loss19812545
    nsv528469CNV Gain19592680


    Human Gene Mutation Database (HGMD): MAP3K15

    Locus Specific Mutation Databases (LSDB): MAP3K15
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP3K15
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP3K15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300820    OMIM disorders: --

    2 diseases for MAP3K15:    About MalaCards
    neuronitis    


    MAP3K15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MAP3K15

    Export disorders for MAP3K15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP3K15 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with MAP3K15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ASK3, a novel member of the apoptosis signal-regulati ng kinase family, is essential for stress-induced cell death in HeLa cells. (PubMed id 20362554)1, 2 Kaji T....Kishimoto T. (2010)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Quantitative analysis of HSP90-client interactions rev eals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (2012)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
    7. Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    9. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
    10. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 389840 HGNC: 31689 AceView: FLJ16518 Ensembl:ENSG00000180815 euGenes: HUgn389840
    ECgene: MAP3K15 H-InvDB: MAP3K15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP3K15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAP3K15 gene:
    Search GeneIP for patents involving MAP3K15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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