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Aliases for MAP3K14 Gene

Aliases for MAP3K14 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 14 2 3
  • HSNIK 3 4 6
  • NIK 3 4 6
  • Serine/Threonine-Protein Kinase NIK 3 4
  • NF-Kappa-Beta-Inducing Kinase 3 4
  • Serine/Threonine Protein-Kinase 2
  • EC 2.7.11.25 4
  • FTDCR1B 3
  • HS 3

External Ids for MAP3K14 Gene

Summaries for MAP3K14 Gene

Entrez Gene Summary for MAP3K14 Gene

  • This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP3K14 Gene

MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include protein kinase activity and NF-kappaB-inducing kinase activity.

UniProtKB/Swiss-Prot for MAP3K14 Gene

  • Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.

Gene Wiki entry for MAP3K14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K14 Gene

Genomics for MAP3K14 Gene

Genomic Location for MAP3K14 Gene

Start:
45,263,121 bp from pter
End:
45,317,048 bp from pter
Size:
53,928 bases
Orientation:
Minus strand

Genomic View for MAP3K14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP3K14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K14 Gene

Regulatory Elements for MAP3K14 Gene

Proteins for MAP3K14 Gene

  • Protein details for MAP3K14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99558-M3K14_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 14
    Protein Accession:
    Q99558
    Secondary Accessions:
    • A8K2D8
    • D3DX67
    • Q8IYN1

    Protein attributes for MAP3K14 Gene

    Size:
    947 amino acids
    Molecular mass:
    104042 Da
    Quaternary structure:
    • Interacts with TRAF2, TRAF5, TRAF6, IKKA and NFKB2/P100 (By similarity). Interacts with TRAF3 and PELI3. Interacts with NIBP; the interaction is direct. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts with ZFP91.

    Three dimensional structures from OCA and Proteopedia for MAP3K14 Gene

neXtProt entry for MAP3K14 Gene

Proteomics data for MAP3K14 Gene at MOPED

Post-translational modifications for MAP3K14 Gene

  • Autophosphorylated. Phosphorylation at Thr-559 is required to activates its kinase activity and Lys-63-linked polyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization.
  • Ubiquitinated. Undergoes both Lys-48- and Lys-63-linked polyubiquitination. Lys-48-linked polyubiquitination leads to its degradation by the proteasome, while Lys-63-linked polyubiquitination stabilizes and activates it
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys106

Other Protein References for MAP3K14 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MAP3K14 Gene

Domains for MAP3K14 Gene

Gene Families for MAP3K14 Gene

HGNC:
  • MAP3K :Mitogen-activated protein kinase cascade / Kinase kinase kinases
IUPHAR :

Protein Domains for MAP3K14 Gene

Suggested Antigen Peptide Sequences for MAP3K14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99558

UniProtKB/Swiss-Prot:

M3K14_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q99558
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.:
    • Q99558
genes like me logo Genes that share domains with MAP3K14: view

Function for MAP3K14 Gene

Molecular function for MAP3K14 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.

Enzyme Numbers (IUBMB) for MAP3K14 Gene

Gene Ontology (GO) - Molecular Function for MAP3K14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 15001576
GO:0004702 receptor signaling protein serine/threonine kinase activity IBA --
GO:0004704 NF-kappaB-inducing kinase activity ISS --
GO:0004708 MAP kinase kinase activity IBA --
GO:0004709 MAP kinase kinase kinase activity IEA --
genes like me logo Genes that share ontologies with MAP3K14: view
genes like me logo Genes that share phenotypes with MAP3K14: view

Animal Models for MAP3K14 Gene

MGI Knock Outs for MAP3K14:

miRNA for MAP3K14 Gene

miRTarBase miRNAs that target MAP3K14

No data available for Transcription Factor Targeting and HOMER Transcription for MAP3K14 Gene

Localization for MAP3K14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP3K14 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP3K14 Gene COMPARTMENTS Subcellular localization image for MAP3K14 gene
Compartment Confidence
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for MAP3K14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAP3K14: view

Pathways for MAP3K14 Gene

genes like me logo Genes that share pathways with MAP3K14: view

Gene Ontology (GO) - Biological Process for MAP3K14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000186 activation of MAPKK activity IEA --
GO:0000187 activation of MAPK activity IBA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with MAP3K14: view

Compounds for MAP3K14 Gene

(2) HMDB Compounds for MAP3K14 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(17) Novoseek inferred chemical compound relationships for MAP3K14 Gene

Compound -log(P) Hits PubMed IDs
tab-1 81.6 5
okadaic acid 42.1 2
rantes 40.4 4
leptomycin b 38.3 2
sp 600125 37.5 1
genes like me logo Genes that share compounds with MAP3K14: view

Transcripts for MAP3K14 Gene

Unigene Clusters for MAP3K14 Gene

Mitogen-activated protein kinase kinase kinase 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K14 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP1:
SP2: -
SP3: -
SP4:

Relevant External Links for MAP3K14 Gene

GeneLoc Exon Structure for
MAP3K14
ECgene alternative splicing isoforms for
MAP3K14

Expression for MAP3K14 Gene

mRNA expression in normal human tissues for MAP3K14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP3K14 Gene

This gene is overexpressed in Muscle - Skeletal (4.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MAP3K14 Gene

SOURCE GeneReport for Unigene cluster for MAP3K14 Gene Hs.404183

mRNA Expression by UniProt/SwissProt for MAP3K14 Gene

Q99558-M3K14_HUMAN
Tissue specificity: Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon.
genes like me logo Genes that share expressions with MAP3K14: view

Orthologs for MAP3K14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP3K14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP3K14 35
  • 99.54 (n)
  • 99.47 (a)
cow
(Bos Taurus)
Mammalia MAP3K14 35
  • 87.99 (n)
  • 89.3 (a)
dog
(Canis familiaris)
Mammalia MAP3K14 35
  • 87.65 (n)
  • 89.44 (a)
mouse
(Mus musculus)
Mammalia Map3k14 35
  • 84.4 (n)
  • 85 (a)
Map3k14 16
rat
(Rattus norvegicus)
Mammalia Map3k14 35
  • 84.36 (n)
  • 85.74 (a)
chicken
(Gallus gallus)
Aves MAP3K14 35
  • 66.29 (n)
  • 63.24 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia map3k14 35
  • 55.85 (n)
  • 48.41 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-260c8.4 35
  • 56.05 (n)
  • 48.84 (a)
Species with no ortholog for MAP3K14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP3K14 Gene

ENSEMBL:
Gene Tree for MAP3K14 (if available)
TreeFam:
Gene Tree for MAP3K14 (if available)

Paralogs for MAP3K14 Gene

Selected SIMAP similar genes for MAP3K14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAP3K14: view

No data available for Paralogs for MAP3K14 Gene

Variants for MAP3K14 Gene

Sequence variations from dbSNP and Humsavar for MAP3K14 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs721579 -- 45,293,115(-) CCCTC(A/G)TTCAG intron-variant
rs994668 -- 45,299,062(-) TCACT(A/G)ACAAC intron-variant
rs1352312 -- 45,299,395(-) TTTTT(A/C/T)TTTTC intron-variant
rs1476532 -- 45,306,230(-) TGCTG(C/T)GTGGC intron-variant
rs1476533 -- 45,306,229(-) GCTGT(A/G)TGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP3K14 Gene

Variant ID Type Subtype PubMed ID
nsv908303 CNV Loss 21882294
esv269245 CNV Insertion 20981092
esv273337 CNV Insertion 20981092

Relevant External Links for MAP3K14 Gene

HapMap Linkage Disequilibrium report
MAP3K14
Human Gene Mutation Database (HGMD)
MAP3K14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K14 Gene

Disorders for MAP3K14 Gene

(8) Novoseek inferred disease relationships for MAP3K14 Gene

Disease -log(P) Hits PubMed IDs
necrosis 65.2 12
leukemia t-cell 52.4 1
tumors 50.5 12
cancer 17 3
shock 0 1

Relevant External Links for MAP3K14

Genetic Association Database (GAD)
MAP3K14
Human Genome Epidemiology (HuGE) Navigator
MAP3K14
genes like me logo Genes that share disorders with MAP3K14: view

No data available for UniProtKB/Swiss-Prot for MAP3K14 Gene

Publications for MAP3K14 Gene

  1. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. (PMID: 9020361) Malinin N.L. … Wallach D. (Nature 1997) 2 3 4 23
  2. NIK is a component of the EGF/heregulin receptor signaling complexes. (PMID: 12853971) Chen D. … Shu H.B. (Oncogene 2003) 3 4 23
  3. Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation. (PMID: 15084608) Liao G. … Sun S.C. (J. Biol. Chem. 2004) 3 4 23
  4. Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation. (PMID: 20501937) Razani B. … Cheng G. (Sci. Signal. 2010) 3 4 23
  5. Interferon induces NF-kappa B-inducing kinase/tumor necrosis factor receptor-associated factor-dependent NF-kappa B activation to promote cell survival. (PMID: 16009713) Yang C.H. … Pfeffer L.M. (J. Biol. Chem. 2005) 3 23

Products for MAP3K14 Gene

Sources for MAP3K14 Gene

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