MAP3K14 Gene
protein-coding GIFtS: 61
GCID: GC17M043433
|
|
mitogen-activated protein kinase kinase kinase 14
| |
Aliases
for MAP3K14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitogen-Activated Protein Kinase Kinase Kinase 141 2 | | Serine/Threonine-Protein Kinase NIK2 3 | | NIK1 2 3 5 | | NF-Kappa-Beta-Inducing Kinase2 3 | | HSNIK1 2 5 | | Serine/Threonine Protein-Kinase2 | | FTDCR1B1 2 | | EC 2.7.11.253 | | HS1 2 | | HsNIK3 |
Export aliases for MAP3K14 gene to outside databasesPrevious GC identifers: GC17M042870 GC17M045504 GC17M043351 GC17M043815 GC17M040696 GC17M039101 GC17M043341 GC17M043370 |
Summaries
for MAP3K14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MAP3K14:
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. Thiskinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKKkinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of thetumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. (provided by RefSeq,Jul 2008)
UniProtKB/Swiss-Prot: M3K14_HUMAN, Q99558Function: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B andits transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-Bvia the non-canonical pathway. Could act in a receptor-selective manner
Gene Wiki entry for MAP3K14
|
Genomic Views
for MAP3K14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAP3K14 gene promoter:
E2F-4 E2F-3a Sox5 E2F-5 E2F-2 LCR-F1 E2F-1 E2F Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAP3K14
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K14 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21-q22MAP3K14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M043433: view genomic region
(about GC identifiers)
Start:
|
43,340,488 bp from pter |
End:
|
43,394,414 bp from pter |
Size:
|
53,927 bases |
Orientation:
|
minus strand |
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Proteins
for MAP3K14 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: M3K14_HUMAN, Q99558 (See
protein sequence)Recommended Name: Mitogen-activated protein kinase kinase kinase 14 Size: 947 amino acids; 104042 Da
Subunit: Interacts with TRAF2, TRAF5, TRAF6, IKKA and NFKB2/P100 (By similarity). Interacts with TRAF3 and PELI3.Interacts with NIBP; the interaction is direct. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts withZFP91
Subcellular location: Cytoplasm
2 PDB 3D structures from  and Proteopedia  for MAP3K14:4DN5 (3D)
4G3D (3D)
Secondary accessions: A8K2D8 D3DX67 Q8IYN1Explore the universe of human proteins at neXtProt for MAP3K14: NX_Q99558
Post-translational modifications:
Autophosphorylated. Phosphorylation at Thr-559 is required to activates its kinase activity and 'Lys-63'-linkedpolyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization1
Ubiquitinated. Undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. 'Lys-48'-linked polyubiquitinationleads to its degradation by the proteasome, while 'Lys-63'-linked polyubiquitination stabilizes and activates it1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q99558
MAP3K14 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003945.2 Reactome Protein details: Q99558
Human Recombinant Protein Products for MAP3K14:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
MAP3K14 for ontologies About GeneDecksing
MAP3K14 Antibody Products:
Assay Products for MAP3K14: |
Protein
Domains /
Families
for MAP3K14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAP3K14 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q99558ProtoNet protein and cluster: Q99558 UniProtKB/Swiss-Prot: M3K14_HUMAN, Q99558Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinasesubfamilySimilarity: Contains 1 protein kinase domain |
Function
for MAP3K14 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: M3K14_HUMAN, Q99558Function: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B andits transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-Bvia the non-canonical pathway. Could act in a receptor-selective mannerCatalytic activity: ATP + a protein = ADP + a phosphoprotein Enzyme Number (IUBMB): EC 2.7.11.251
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
MAP3K14 for ontologies About GeneDecksing
Phenotypes:
4 GenomeRNAi human phenotypes for MAP3K14:
13 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Map3k14):
MAP3K14 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Map3k14tm1Rds for MAP3K14
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K14 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K14 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MAP3K14 (NM_003954) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAP3K14 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K14 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K14 |
|
Pathways & Interactions
for MAP3K14 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/44 super-pathways (see all 44) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TWEAK Pathway | | | 2 | 4-1BB Pathway | | | 3 | BAFF in B-Cell Signaling | | | 4 | Apoptosis and survival_Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway | | | 5 | Immune response_Bacterial infections in normal airways | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/11 EMD Millipore Pathways for MAP3K14 (see all 11)
5/30 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP3K14 (see all 30)
1 
Cell Signaling Technology (CST) Pathway for MAP3K14
5/16  GeneGo (Thomson Reuters) Pathways for MAP3K14 (see all 16)
5/15  BioSystems Pathways for MAP3K14 (see all 15)
5 
Reactome Pathways for MAP3K14
5/6 
Kegg Pathways (Kegg details for MAP3K14) (see all 6):
MAP3K14 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP3K14
5/154 Interacting proteins for MAP3K14 (Q995581, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 154)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
MAP3K14 for ontologies About GeneDecksing
|
Drugs & Compounds
for MAP3K14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MAP3K14 for compounds About GeneDecksing
 Browse Tocris compounds for MAP3K14
2 HMDB Compounds for MAP3K14 About this table
10/17 Novoseek chemical compound relationships for MAP3K14 gene (see all 17) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tab-1 |
81.6 |
5 |
17439942 (1), 17633026 (1), 12243350 (1), 12598905 (1) (see all 5) |
| okadaic acid |
42.1 |
3 |
11510478 (1), 16286467 (1) |
| rantes |
40.4 |
5 |
12243350 (3), 16971487 (1) |
| leptomycin b |
38.3 |
3 |
11801607 (1), 10655476 (1) |
| sp 600125 |
37.5 |
1 |
19097143 (1) |
| serine |
33.4 |
6 |
12707358 (1), 20501937 (1), 9820741 (1), 14676825 (1) (see all 5) |
| wortmannin |
17.4 |
2 |
15665513 (1) |
| pd 98,059 |
17.4 |
1 |
11773061 (1) |
| egcg |
16.7 |
4 |
11510478 (1), 11502884 (1) |
| ly294002 |
8.16 |
2 |
15665513 (1) |
Search CenterWatch for drugs/clinical trials and news about MAP3K14 / M3K14
|
Transcripts
for MAP3K14 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAP3K14 gene: NM_003954.3 Unigene Cluster for MAP3K14: Mitogen-activated protein kinase kinase kinase 14 Hs.404183 [show with all ESTs]Unigene Representative Sequence: Y102565 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000587332 ENST00000592267 ENST00000586644 ENST00000344686(uc002iiu.1 uc010daj.1 uc002iiv.1 uc002iiw.1)
ENST00000376926
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K14 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K14 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MAP3K14 (NM_003954) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAP3K14 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K14 |
Additional cDNA sequence: AJ008134.1 AJ008136.1 AJ008137.1 AJ008140.1 AJ008141.1 AJ008142.1 AJ008143.1 AJ008144.1 AJ008145.1 AJ008146.1 AJ008147.1 AJ008148.1 AJ008149.1 AJ008150.1 AJ008151.1 AJ008152.1 AJ008153.1 AJ008157.1 AJ008158.1 AJ008159.1 AJ008160.1 AJ008161.1 AJ008162.1 AK123696.1 AK131438.1 AK290203.1 AK313085.1 BC022296.1 BC035576.1 CR749592.1 Y10256.1 12 DOTS entries: DT.100013156 DT.97795488 DT.312989 DT.120945656 DT.91921823 DT.86852054 DT.97813527 DT.120945618 DT.101959307 DT.120945522 DT.92039308 DT.120945558 24/116 AceView cDNA sequences (see all 116): AJ008135 AJ008146 AW298578 AJ008136 BE645094 AA812002 AJ008161 AW274999 AJ008139 AW516248 AJ008159 AJ008145 AK131438 AJ008156 AJ008144 AA595297 AL708587 BM914630 AJ008147 CR612342 F10133 AJ008143 AA621781 BQ711607
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K14 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MAP3K14
|
Expression
for MAP3K14 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAP3K14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGACTCCTCA
About this image
See MAP3K14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAP3K14
SOURCE GeneReport for Unigene cluster: Hs.404183
UniProtKB/Swiss-Prot: M3K14_HUMAN, Q99558Tissue specificity: Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate,ovary and colon
SABiosciences Custom PCR Arrays for MAP3K14
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP3K14
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAP3K14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP3K14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP3K14 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K14 |
Orthologs
for MAP3K14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MAP3K14 gene from 3/7 species (see all 7) About this table
ENSEMBL Gene Tree for MAP3K14 (if available)
TreeFam Gene Tree for MAP3K14 (if available) |
Paralogs
for MAP3K14 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MAP3K14 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAP3K14 (43340488 - 43394414 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MAP3K14
2 CNVs: 34629 34646 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP3K14 |
|
Disorders
/ Diseases
for MAP3K14 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAP3K14 for disorders About GeneDecksing
OMIM gene information: 604655
OMIM disorders: --
20/29  diseases for MAP3K14 (see all 29): About MalaCardshuman t-cell leukemia virus type 1 salivary gland cancer ectodermal dysplasia frontotemporal dementia
chikungunya rheumatoid arthritis chronic lymphocytic leukemia lymphocytic leukemia
insulin resistance multiple myeloma t-cell leukemia ptosis
down syndrome dementia leukemia hepatitis b
arthritis myeloma pancreatic cancer melanoma
8 Novoseek disease relationships for MAP3K14 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
65.2 |
13 |
12853971 (1), 16223731 (1), 15208311 (1), 20501937 (1) (see all 12) |
| leukemia t-cell |
52.4 |
1 |
10385526 (1) |
| tumors |
50.5 |
13 |
12853971 (1), 16223731 (1), 15208311 (1), 20501937 (1) (see all 12) |
| cancer |
17 |
4 |
11510478 (1), 11520600 (1), 19538528 (1) |
| shock |
0 |
1 |
17563756 (1) |
| rheumatoid arthritis |
0 |
1 |
11698466 (1) |
| lymphoma |
0 |
1 |
19897484 (1) |
| melanoma |
0 |
6 |
18347013 (3), 15027484 (1), 11773061 (1) |
Human Genome Epidemiology (HuGE) Navigator: MAP3K14 (7 documents)
Export disorders for MAP3K14 gene to outside databases
|
Publications
for MAP3K14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAP3K14 gene, integrated from 9 sources (see all 243):
(articles sorted by number of sources associating them with MAP3K14) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. (PubMed id 9020361)1, 2, 3, 9 Malinin N.L.... Wallach D. (1997)
- NIK is a component of the EGF/heregulin receptor signaling complexes. (PubMed id 12853971)1, 2, 9 Chen D.... Shu H.B. (2003)
- Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation. (PubMed id 20501937)1, 2, 9 Razani B....Cheng G. (2010)
- Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation. (PubMed id 15084608)1, 2, 9 Liao G....Sun S.C. (2004)
- An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination. (PubMed id 20682767)1, 2 Jin X.... Lee J.J. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein. (PubMed id 12874243)1, 2 Jensen L.E. and Whitehead A.S. (2003)
- Allosteric regulation of the ubiquitin:NIK and ubiqui tin:TRAF3 E3 ligases by the lymphotoxin-beta receptor. (PubMed id 20348096)1, 9 Sanjo H....Ware C.F. (2010)
- Hsp90 regulates processing of NF-kappaB2 p100 involving protection of NF-kappaB-inducing kinase (NIK) from autophagy-mediated degradation. (PubMed id 17563756)1, 9 Qing G....Xiao G. (2007)
- Molecular determinants of NF-kappaB-inducing kinase action. (PubMed id 9742107)1, 9 Lin X....Greene W.C. (1998)
|
External Searches for MAP3K14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MAP3K14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MAP3K14 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAP3K14 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MAP3K14 gene:
Search GeneIP for patents involving MAP3K14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MAP3K14 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for MAP3K14 | | OriGene shRNA RFP for MAP3K14 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP3K14 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP3K14 | | | OriGene Protein Over-expression Lysate for MAP3K14 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAP3K14 | | OriGene 3'-UTR Clone for MAP3K14 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K14 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K14 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MAP3K14 | | OriGene Custom Protein Services for MAP3K14 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAP3K14 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP3K14 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K14 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP3K14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP3K14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP3K14 |
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| | Antibodies & Assays for MAP3K14 (Nik) |
| | | | Search Tocris compounds for MAP3K14 |
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 | | | MAP3K14 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K14 |
|  |  |  |  | | | | ThermoFisher Antibodies for MAP3K14 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K14 |
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