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MAP3K14 Gene

protein-coding   GIFtS: 65
GCID: GC17M043534

Mitogen-Activated Protein Kinase Kinase Kinase 14

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 141 2     Serine/Threonine Protein-Kinase1
NIK2 3 5     FTDCR1B2
Serine/Threonine-Protein Kinase NIK2 3     HS2
NF-Kappa-Beta-Inducing Kinase2 3     EC 2.7.11.253
HSNIK2 5     HsNIK3

External Ids:    HGNC: 68531   Entrez Gene: 90202   Ensembl: ENSG000000060627   OMIM: 6046555   UniProtKB: Q995583   

Export aliases for MAP3K14 gene to outside databases

Previous GC identifers: GC17M042870 GC17M045504 GC17M043351 GC17M043815 GC17M040696 GC17M039101 GC17M043341 GC17M043370 GC17M043433 GC17M043466


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP3K14 Gene:
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase.
This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other
MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the
tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. (provided by
RefSeq, Jul 2008)

GeneCards Summary for MAP3K14 Gene:
MAP3K14 (mitogen-activated protein kinase kinase kinase 14) is a protein-coding gene. Diseases associated with MAP3K14 include salivary gland cancer, and chikungunya. GO annotations related to this gene include NF-kappaB-inducing kinase activity and protein kinase activity.

UniProtKB/Swiss-Prot: M3K14_HUMAN, Q99558
Function: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B
and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of
NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner

Gene Wiki entry for MAP3K14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP3K14 gene promoter:
         E2F-4   E2F-3a   Sox5   E2F-5   E2F-2   LCR-F1   E2F-1   E2F   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP3K14 promoter sequence
   Search Chromatin IP Primers for MAP3K14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP3K14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21-q22

MAP3K14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K14 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M043534:  view genomic region     (about GC identifiers)

Start:
43,340,488 bp from pter      End:
43,394,414 bp from pter
Size:
53,927 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: M3K14_HUMAN, Q99558 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 14  
Size: 947 amino acids; 104042 Da
Subunit: Interacts with TRAF2, TRAF5, TRAF6, IKKA and NFKB2/P100 (By similarity). Interacts with TRAF3 and PELI3.
Interacts with NIBP; the interaction is direct. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts
with ZFP91
4 PDB 3D structures from and Proteopedia for MAP3K14:
4DN5 (3D)        4G3D (3D)        4IDT (3D)        4IDV (3D)    
Secondary accessions: A8K2D8 D3DX67 Q8IYN1

Explore the universe of human proteins at neXtProt for MAP3K14: NX_Q99558

Explore proteomics data for MAP3K14 at MOPED

Post-translational modifications: 

  • Autophosphorylated. Phosphorylation at Thr-559 is required to activates its kinase activity and 'Lys-63'-linked
    polyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization1
  • Ubiquitinated. Undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. 'Lys-48'-linked polyubiquitination
    leads to its degradation by the proteasome, while 'Lys-63'-linked polyubiquitination stabilizes and activates it1
  • Ubiquitination2 at Lys106
  • Modification sites at PhosphoSitePlus

  • See MAP3K14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003945.2  Reactome Protein details: Q99558

    MAP3K14 Human Recombinant Protein Products:

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    MAP3K14 Antibody Products:

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    MAP3K14 Assay Products:

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    Cloud-Clone Corp. ELISAs for MAP3K14
    Cloud-Clone Corp. CLIAs for MAP3K14


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAP3K: Mitogen-activated protein kinase cascade / Kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase 14
    STE-unique family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom
     IPR017425 MAPKKK14

    Graphical View of Domain Structure for InterPro Entry Q99558

    ProtoNet protein and cluster: Q99558

    UniProtKB/Swiss-Prot: M3K14_HUMAN, Q99558
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain


    MAP3K14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M3K14_HUMAN, Q99558
    Function: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B
    and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of
    NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.251

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA15001576
    GO:0004704NF-kappaB-inducing kinase activity ISS--
    GO:0004709MAP kinase kinase kinase activity IEA--
    GO:0005515protein binding IPI10733566
    GO:0005524ATP binding IEA--
         
    MAP3K14 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for MAP3K14:
     Decreased Hepatitis C virus re  Decreased substrate adherent c  Increased viability with 4OH t  Reduced beta-catenin activity  

         12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Map3k14):
     adipose tissue  digestive/alimentary  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  integument  liver/biliary system  mortality/aging  renal/urinary system 
     respiratory system  vision/eye 

    MAP3K14 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Map3k14tm1Rds for MAP3K14

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAP3K14
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP3K14
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP3K14

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MAP3K14 (see all 44):
    hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-513a-5p hsa-miR-106a hsa-miR-301a hsa-miR-759 hsa-miR-1304
    SwitchGear 3'UTR luciferase reporter plasmidMAP3K14 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    M3K14_HUMAN, Q99558: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    MAP3K14 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP3K14 About   (see all 46)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1NOD-like Receptor Signaling Pathways
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    Immune response IL 1 signaling pathway0.42
    2TWEAK Pathway
    TWEAK Pathway0.87
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    DR3 Signaling0.87
    Apoptotic Pathways Triggered By HIV10.42
    TNFR1 Pathway0.56
    Apoptosis through Death Receptors0.42
    TNF Signaling0.55
    Fas Signaling0.35
    3Immune response Bacterial infections in normal airways
    Immune response Bacterial infections in normal airways0.78
    IL 1 beta dependent CFTR expression0.43
    Bacterial infections in CF airways0.78
    Transcription NF kB signaling pathway0.32
    Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response0.47
    4RANK Signaling in Osteoclasts
    BAFF in B-Cell Signaling0.92
    RANK Signaling in Osteoclasts0.45
    APRIL Pathway0.92
    Apoptosis and survival APRIL and BAFF signaling0.39
    5MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for MAP3K14
        Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAP3K14 (see all 30)
        Caspase Cascade
    TWEAK Pathway
    14-3-3 Induced Apoptosis
    LT-BetaR Pathway
    TRAF Pathway

    1 Cell Signaling Technology (CST) Pathway for MAP3K14
        NF-kappaB Signaling

    Selected GeneGo (Thomson Reuters) Pathways for MAP3K14 (see all 16)
        Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
    Immune response Bacterial infections in normal airways
    Immune response IL-9 signaling pathway
    Immune response IL-12-induced IFN-gamma production
    Bacterial infections in CF airways

    Selected BioSystems Pathways for MAP3K14 (see all 16)
        Osteopontin Signaling
    MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    EBV LMP1 signaling
    Apoptosis Modulation and Signaling

    1 Sino Biological Pathway for MAP3K14
        Death Receptor Signaling

    1 Reactome Pathway for MAP3K14
        CD28 dependent PI3K/Akt signaling


    Selected Kegg Pathways  (Kegg details for MAP3K14) (see all 10):
        MAPK signaling pathway
    NF-kappa B signaling pathway
    Apoptosis
    Osteoclast differentiation
    T cell receptor signaling pathway


    MAP3K14 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAP3K14
    Interactions:

        GeneGlobe Interaction Network for MAP3K14

    Selected Interacting proteins for MAP3K14 (Q995581, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 168)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALPLP051861, 2, 3EBI-358011,EBI-1054354 MINT-8216341 MINT-8216325 MINT-8216333 MINT-8216353 I2D: score=3 
    CHUKO151111, 2, 3EBI-358011,EBI-81249 MINT-48791 MINT-47999 MINT-1955970 I2D: score=7 
    IKBKBO149201, 2, 3EBI-358011,EBI-81266 MINT-48000 MINT-48828 I2D: score=7 
    HSP90AB1P082381, 2, 3EBI-358011,EBI-352572 MINT-47998 MINT-48880 I2D: score=4 
    ENSG00000183311P074372, 3MINT-48844 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response ISS--
    GO:0007249I-kappaB kinase/NF-kappaB signaling ISS--
    GO:0031295T cell costimulation TAS--
    GO:0038061NIK/NF-kappaB signaling ISS--
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling RCA19641626

    MAP3K14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAP3K14 (M3K14)

    2 HMDB Compounds for MAP3K14    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Selected Novoseek inferred chemical compound relationships for MAP3K14 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tab-1 81.6 5 17439942 (1), 17633026 (1), 12243350 (1), 12598905 (1) (see all 5)
    okadaic acid 42.1 3 11510478 (1), 16286467 (1)
    rantes 40.4 5 12243350 (3), 16971487 (1)
    leptomycin b 38.3 3 11801607 (1), 10655476 (1)
    sp 600125 37.5 1 19097143 (1)
    serine 33.4 6 12707358 (1), 20501937 (1), 9820741 (1), 14676825 (1) (see all 5)
    wortmannin 17.4 2 15665513 (1)
    pd 98,059 17.4 1 11773061 (1)
    egcg 16.7 4 11510478 (1), 11502884 (1)
    ly294002 8.16 2 15665513 (1)



    MAP3K14 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAP3K14 gene: 
    NM_003954.4  

    Unigene Cluster for MAP3K14:

    Mitogen-activated protein kinase kinase kinase 14
    Hs.404183  [show with all ESTs]
    Unigene Representative Sequence: Y10256
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587332(processed_transcript) ENST00000592267(processed_transcript) ENST00000586644(processed_transcript) ENST00000344686(processed_transcript) ENST00000376926(processed_transcript)

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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat MAP3K14
      QuantiFast Probe-based Assays in human, mouse, rat MAP3K14

    Additional mRNA sequence: 

    AJ008134.1 AJ008136.1 AJ008137.1 AJ008140.1 AJ008141.1 AJ008142.1 AJ008143.1 AJ008144.1 
    AJ008145.1 AJ008146.1 AJ008147.1 AJ008148.1 AJ008149.1 AJ008150.1 AJ008151.1 AJ008152.1 
    AJ008153.1 AJ008157.1 AJ008158.1 AJ008159.1 AJ008160.1 AJ008161.1 AJ008162.1 AK123696.1 
    AK131438.1 AK290203.1 AK313085.1 BC022296.1 BC035576.1 CR749592.1 Y10256.1 

    12 DOTS entries:

    DT.100013156  DT.97795488  DT.312989  DT.120945656  DT.91921823  DT.86852054  DT.97813527  DT.120945618 
    DT.101959307  DT.120945522  DT.92039308  DT.120945558 

    Selected AceView cDNA sequences (see all 116):

    AL708587 AJ008148 BQ711607 AJ008157 AJ008149 AJ008147 AJ008151 AJ008145 
    AA595297 AI262153 AJ008143 CR612342 AJ008139 BM550076 AJ008152 AK131438 
    AJ008144 AJ008146 AW298578 AJ008161 AW274999 AJ008135 AA812002 BM914630 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K14    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
    SP1:                                                                              
    SP2:              -                                                               
    SP3:                                                  -                           
    SP4:                                                                              


    ECgene alternative splicing isoforms for MAP3K14

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAP3K14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACTCCTCA
    MAP3K14 Expression
    About this image


    MAP3K14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    MAP3K14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP3K14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.404183

    UniProtKB/Swiss-Prot: M3K14_HUMAN, Q99558
    Tissue specificity: Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes,
    prostate, ovary and colon

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MAP3K14 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map3k141 , 5 mitogen-activated protein kinase kinase kinase 141, 5 84.4(n)1
    85(a)1
      11 (66.80 cM)5
    538591  NM_016896.31  NP_058592.11 
     1032197625 
    chicken
    (Gallus gallus)
    Aves MAP3K141 mitogen-activated protein kinase kinase kinase 14 66.29(n)
    63.24(a)
      419964  NM_001030927.1  NP_001026098.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia map3k141 mitogen-activated protein kinase kinase kinase 14 55.85(n)
    48.41(a)
      100489201  XM_002935549.2  XP_002935595.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-260c8.41 si:dkey-260c8.4 56.05(n)
    48.84(a)
      100004261  XM_005164157.1  XP_005164214.1 


    ENSEMBL Gene Tree for MAP3K14 (if available)
    TreeFam Gene Tree for MAP3K14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP3K14 gene
    1 SIMAP similar gene for MAP3K14 using alignment to 1 protein entry:     M3K14_HUMAN:
    DKFZp686J04131

    MAP3K14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP3K14 (see all 1011)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0407124
    A lung neuroendocrine carcinoma sample4--see VAR_0407122 G K mis40--------
    VAR_0407144
    An ovarian mucinous carcinoma sample4--see VAR_0407142 T I mis40--------
    rs1842588221,2
    C--44130674(+) CACAAA/GGCATG 1 -- int10--------
    rs1482580951,2
    --44131031(+) ACAACA/CCAGAC 1 -- ut310--------
    rs1890364381,2
    --44131084(+) GGGCTC/TTCTCC 1 -- ut310--------
    rs558553871,2
    C,F--44131091(+) CTCCCC/TGGGAG 1 -- ut311Minor allele frequency- T:0.02EA 120
    rs10478411,2
    C,F,H--44131116(-) CAGCTG/ATCCAC 1 -- ut31 ese318Minor allele frequency- A:0.08MN NS EA NA 1630
    rs129361561,2
    C,F,A,H--44131165(+) TCCCAC/TGGAGT 1 -- ut316Minor allele frequency- T:0.01NS EA NA 424
    rs348836511,2
    C,F--44131194(-) CTCAAC/TCTCCT 1 -- ut313Minor allele frequency- T:0.03NS WA 208
    rs1473860151,2
    C--44131259(+) AGTAGC/TTCCCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MAP3K14 (43340488 - 43394414 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MAP3K14:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv273337CNV Insertion20981092
    esv269245CNV Insertion20981092
    nsv908303CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP3K14
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP3K14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604655    OMIM disorders: --

    Selected diseases for MAP3K14 (see all 33):    
    About MalaCards
    salivary gland cancer    chikungunya    hypereosinophilic syndrome    frontotemporal dementia
    ectodermal dysplasia    human t-cell leukemia virus type 1    septic shock    dementia
    t-cell leukemia    down syndrome    multiple myeloma    rheumatoid arthritis
    myeloma    insulin resistance    arthritis    melanoma
    chronic lymphocytic leukemia    ischemia    hodgkin's lymphoma    multiple sclerosis


    MAP3K14 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for MAP3K14 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 65.2 13 12853971 (1), 16223731 (1), 15208311 (1), 20501937 (1) (see all 12)
    leukemia t-cell 52.4 1 10385526 (1)
    tumors 50.5 13 12853971 (1), 16223731 (1), 15208311 (1), 20501937 (1) (see all 12)
    cancer 17 4 11510478 (1), 11520600 (1), 19538528 (1)
    shock 0 1 17563756 (1)
    rheumatoid arthritis 0 1 11698466 (1)
    lymphoma 0 1 19897484 (1)
    melanoma 0 6 18347013 (3), 15027484 (1), 11773061 (1)

    Genetic Association Database (GAD): MAP3K14
    Human Genome Epidemiology (HuGE) Navigator: MAP3K14 (7 documents)

    Export disorders for MAP3K14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP3K14 gene, integrated from 10 sources (see all 253):
    (articles sorted by number of sources associating them with MAP3K14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. (PubMed id 9020361)1, 2, 3, 9 Malinin N.L.... Wallach D. (Nature 1997)
    2. NIK is a component of the EGF/heregulin receptor signaling complexes. (PubMed id 12853971)1, 2, 9 Chen D.... Shu H.B. (Oncogene 2003)
    3. Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation. (PubMed id 20501937)1, 2, 9 Razani B.... Cheng G. (Sci. Signal. 2010)
    4. Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation. (PubMed id 15084608)1, 2, 9 Liao G.... Sun S.C. (J. Biol. Chem. 2004)
    5. Structure of the nuclear factor kappaB-inducing kinase (NIK) kinase domain reveals a constitutively active conformation. (PubMed id 22718757)1, 2 Liu J.... Wang Z. (J. Biol. Chem. 2012)
    6. An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination. (PubMed id 20682767)1, 2 Jin X.... Lee J.J. (J. Biol. Chem. 2010)
    7. Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. (PubMed id 19262425)1, 4 Bowes J.D....Barton A. (Pharmacogenet. Genomics 2009)
    8. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    9. Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. (PubMed id 18434448)1, 4 Dieguez-Gonzalez R....Gonzalez A. (Ann. Rheum. Dis. 2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9020 HGNC: 6853 AceView: MAP3K14 Ensembl:ENSG00000006062 euGenes: HUgn9020
    ECgene: MAP3K14 Kegg: 9020 H-InvDB: MAP3K14

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAP3K14 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP3K14 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAP3K14 gene:
    Search GeneIP for patents involving MAP3K14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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