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Aliases for MAP3K14 Gene

Aliases for MAP3K14 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 14 2 3 5
  • Serine/Threonine-Protein Kinase NIK 3 4
  • NF-Kappa-Beta-Inducing Kinase 3 4
  • HSNIK 3 4
  • NIK 3 4
  • Serine/Threonine Protein-Kinase 2
  • EC 2.7.11.25 4
  • FTDCR1B 3
  • HS 3

External Ids for MAP3K14 Gene

Previous GeneCards Identifiers for MAP3K14 Gene

  • GC17M042870
  • GC17M045504
  • GC17M043351
  • GC17M043815
  • GC17M040696
  • GC17M039101
  • GC17M043341
  • GC17M043370
  • GC17M043433
  • GC17M043466
  • GC17M043534

Summaries for MAP3K14 Gene

Entrez Gene Summary for MAP3K14 Gene

  • This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP3K14 Gene

MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14) is a Protein Coding gene. Diseases associated with MAP3K14 include Nik Deficiency. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and HTLV-I infection. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP3K15.

UniProtKB/Swiss-Prot for MAP3K14 Gene

  • Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.

Gene Wiki entry for MAP3K14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K14 Gene

Genomics for MAP3K14 Gene

Regulatory Elements for MAP3K14 Gene

Enhancers for MAP3K14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F045287 0.2 ENCODE 22.7 +28.1 28125 3.3 ARNT ARID4B SIN3A ZNF2 SLC30A9 ZNF302 ZNF143 ZNF207 CEBPZ NFYC KANSL1 LOC102724391 MAP3K14 SPATA32 EFTUD2 ENSG00000267788 RN7SL405P ENSG00000265964 ENSG00000265547 SMCO4P1
GH17F045345 1.3 Ensembl ENCODE 12.1 -28.9 -28902 1.9 PKNOX1 ARNT FEZF1 ZNF2 REST MEF2D ZNF610 SMARCA4 GLIS1 NBN MAP3K14 SPATA32 FMNL1 EFTUD2 HEXIM1 CRHR1-IT1 LRRC37A4P MAPK8IP1P2 DND1P1 KANSL1-AS1
GH17F045347 0.2 Ensembl 12.1 -30.2 -30237 0.2 MAP3K14 SPATA32 RNA5SP443 GC17M045328 LOC105371796
GH17F045368 0.5 ENCODE 12 -51.8 -51782 1.1 ZNF121 MAP3K14 CRHR1-IT1 ENSG00000267446 LOC105371796
GH17F045369 0.7 ENCODE 12 -53.0 -53043 0.7 SCRT1 ZNF362 ZNF146 GLIS1 MAP3K14 ENSG00000267446 LOC105371796
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MAP3K14 on UCSC Golden Path with GeneCards custom track

Promoters for MAP3K14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001347394 564 3001 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for MAP3K14 Gene

Chromosome:
17
Start:
45,263,119 bp from pter
End:
45,317,064 bp from pter
Size:
53,946 bases
Orientation:
Minus strand

Genomic View for MAP3K14 Gene

Genes around MAP3K14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K14 Gene

Proteins for MAP3K14 Gene

  • Protein details for MAP3K14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99558-M3K14_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 14
    Protein Accession:
    Q99558
    Secondary Accessions:
    • A8K2D8
    • D3DX67
    • Q8IYN1

    Protein attributes for MAP3K14 Gene

    Size:
    947 amino acids
    Molecular mass:
    104042 Da
    Quaternary structure:
    • Interacts with TRAF2, TRAF5, TRAF6, IKKA and NFKB2/P100 (By similarity). Interacts with TRAF3 and PELI3. Interacts with NIBP; the interaction is direct. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts with ZFP91.

    Three dimensional structures from OCA and Proteopedia for MAP3K14 Gene

neXtProt entry for MAP3K14 Gene

Post-translational modifications for MAP3K14 Gene

  • Autophosphorylated. Phosphorylation at Thr-559 is required to activates its kinase activity and Lys-63-linked polyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization.
  • Ubiquitinated. Undergoes both Lys-48- and Lys-63-linked polyubiquitination. Lys-48-linked polyubiquitination leads to its degradation by the proteasome, while Lys-63-linked polyubiquitination stabilizes and activates it.
  • Ubiquitination at Lys 106
  • Modification sites at PhosphoSitePlus

Other Protein References for MAP3K14 Gene

Antibody Products

  • R&D Systems Antibodies for MAP3K14 (NIK/MAP3K14)
  • Cell Signaling Technology (CST) Antibodies for MAP3K14 (Nik)
  • Abcam antibodies for MAP3K14
  • Santa Cruz Biotechnology (SCBT) Antibodies for MAP3K14

No data available for DME Specific Peptides for MAP3K14 Gene

Domains & Families for MAP3K14 Gene

Suggested Antigen Peptide Sequences for MAP3K14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99558

UniProtKB/Swiss-Prot:

M3K14_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K14: view

Function for MAP3K14 Gene

Molecular function for MAP3K14 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.

Enzyme Numbers (IUBMB) for MAP3K14 Gene

Gene Ontology (GO) - Molecular Function for MAP3K14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IDA 15001576
GO:0004674 protein serine/threonine kinase activity EXP 9520446
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity IBA --
GO:0004704 NF-kappaB-inducing kinase activity IEA,ISS --
genes like me logo Genes that share ontologies with MAP3K14: view
genes like me logo Genes that share phenotypes with MAP3K14: view

Animal Models for MAP3K14 Gene

MGI Knock Outs for MAP3K14:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K14 Gene

Localization for MAP3K14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP3K14 Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for MAP3K14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAP3K14: view

No data available for Subcellular locations from COMPARTMENTS for MAP3K14 Gene

Pathways & Interactions for MAP3K14 Gene

genes like me logo Genes that share pathways with MAP3K14: view

SIGNOR curated interactions for MAP3K14 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAP3K14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000186 activation of MAPKK activity IEA --
GO:0006468 protein phosphorylation IEA --
GO:0006955 immune response IEA,ISS --
GO:0007249 I-kappaB kinase/NF-kappaB signaling IEA,ISS --
genes like me logo Genes that share ontologies with MAP3K14: view

Drugs & Compounds for MAP3K14 Gene

(10) Drugs for MAP3K14 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(9) Additional Compounds for MAP3K14 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MAP3K14: view

Transcripts for MAP3K14 Gene

Unigene Clusters for MAP3K14 Gene

Mitogen-activated protein kinase kinase kinase 14:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K14 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP1:
SP2: -
SP3: -
SP4:

Relevant External Links for MAP3K14 Gene

GeneLoc Exon Structure for
MAP3K14
ECgene alternative splicing isoforms for
MAP3K14

Expression for MAP3K14 Gene

mRNA expression in normal human tissues for MAP3K14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP3K14 Gene

This gene is overexpressed in Muscle - Skeletal (x4.4).

Protein differential expression in normal tissues from HIPED for MAP3K14 Gene

This gene is overexpressed in Gallbladder (16.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MAP3K14 Gene



NURSA nuclear receptor signaling pathways regulating expression of MAP3K14 Gene:

MAP3K14

SOURCE GeneReport for Unigene cluster for MAP3K14 Gene:

Hs.404183

mRNA Expression by UniProt/SwissProt for MAP3K14 Gene:

Q99558-M3K14_HUMAN
Tissue specificity: Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon.
genes like me logo Genes that share expression patterns with MAP3K14: view

Primer Products

No data available for Protein tissue co-expression partners for MAP3K14 Gene

Orthologs for MAP3K14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP3K14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP3K14 34
  • 99.54 (n)
cow
(Bos Taurus)
Mammalia MAP3K14 34
  • 87.99 (n)
dog
(Canis familiaris)
Mammalia MAP3K14 34
  • 87.65 (n)
mouse
(Mus musculus)
Mammalia Map3k14 34 16
  • 84.4 (n)
rat
(Rattus norvegicus)
Mammalia Map3k14 34
  • 84.36 (n)
chicken
(Gallus gallus)
Aves MAP3K14 34
  • 66.29 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia map3k14 34
  • 55.85 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-260c8.4 34
  • 56.05 (n)
Species where no ortholog for MAP3K14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP3K14 Gene

ENSEMBL:
Gene Tree for MAP3K14 (if available)
TreeFam:
Gene Tree for MAP3K14 (if available)

Paralogs for MAP3K14 Gene

Paralogs for MAP3K14 Gene

(1) SIMAP similar genes for MAP3K14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAP3K14: view

Variants for MAP3K14 Gene

Sequence variations from dbSNP and Humsavar for MAP3K14 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_040712 A lung neuroendocrine carcinoma sample
VAR_040714 An ovarian mucinous carcinoma sample
rs1047833 -- 45,264,774(-) TTGGT(C/G)ACCAA intron-variant, nc-transcript-variant, reference, synonymous-codon
rs1047841 -- 45,263,264(-) CAGCT(A/G)TCCAC intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs10578692 -- 45,291,297(+) ATATC(-/TG)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP3K14 Gene

Variant ID Type Subtype PubMed ID
dgv1472n106 CNV deletion 24896259
esv3309064 CNV mobile element insertion 20981092
esv3336642 CNV insertion 20981092
esv3422273 CNV insertion 20981092
esv3640660 CNV loss 21293372
nsv1070831 CNV deletion 25765185
nsv1146669 OTHER inversion 26484159
nsv953904 CNV deletion 24416366

Relevant External Links for MAP3K14 Gene

Human Gene Mutation Database (HGMD)
MAP3K14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP3K14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MAP3K14 Gene

Disorders for MAP3K14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAP3K14 Gene - From: Orphanet

Disorder Aliases PubMed IDs
nik deficiency
  • primary immunodeficiency with multifaceted aberrant lymphoid immunity
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAP3K14

Genetic Association Database (GAD)
MAP3K14
Human Genome Epidemiology (HuGE) Navigator
MAP3K14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP3K14
genes like me logo Genes that share disorders with MAP3K14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP3K14 Gene

Publications for MAP3K14 Gene

  1. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. (PMID: 9020361) Malinin N.L. … Wallach D. (Nature 1997) 2 3 4 22 64
  2. Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation. (PMID: 20501937) Razani B. … Cheng G. (Sci. Signal. 2010) 3 4 22 64
  3. Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation. (PMID: 15084608) Liao G. … Sun S.C. (J. Biol. Chem. 2004) 3 4 22 64
  4. NIK is a component of the EGF/heregulin receptor signaling complexes. (PMID: 12853971) Chen D. … Shu H.B. (Oncogene 2003) 3 4 22 64
  5. Structure of the nuclear factor kappaB-inducing kinase (NIK) kinase domain reveals a constitutively active conformation. (PMID: 22718757) Liu J. … Wang Z. (J. Biol. Chem. 2012) 3 4 64

Products for MAP3K14 Gene

Sources for MAP3K14 Gene

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