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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP3K13 Gene

protein-coding   GIFtS: 62
GCID: GC03P185000

mitogen-activated protein kinase kinase kinase 13
 Explore 10 diseases affiliated with
MAP3K13 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAP3K13    

Aliases
for MAP3K13 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 131 2     Mixed Lineage Kinase2 3
LZK1 2 3 5     MLK2 3
MEKK131 2     EC 2.7.11.253 8
Leucine Zipper-Bearing Kinase2 3     EC 2.7.118

External Ids:    HGNC: 68521   Entrez Gene: 91752   Ensembl: ENSG000000738037   OMIM: 6049155   UniProtKB: O432833   

Export aliases for MAP3K13 gene to outside databases

Previous GC identifers: GC03P181938 GC03P186229 GC03P186482 GC03P186401 GC03P186563 GC03P182490


Summaries
for MAP3K13 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAP3K13:
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual
leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can
phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: M3K13_HUMAN, O43283
Function: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically
with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves
activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B

Gene Wiki entry for MAP3K13


Genomic Views
for MAP3K13 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP3K13 gene promoter:
         Sox5   AP-1   ATF-2   FOXO3   HNF-1A   HNF-1   FOXJ2 (long isoform)   c-Jun   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAP3K13 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP3K13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27   Ensembl cytogenetic band:  3q27.2   HGNC cytogenetic band: 3q27

MAP3K13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K13 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P185000:  view genomic region     (about GC identifiers)

Start:
 185,000,729 bp from pter      End:
 185,206,885 bp from pter
Size:
 206,157 bases      Orientation:
 plus strand

Proteins
for MAP3K13 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: M3K13_HUMAN, O43283 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 13  
Size: 966 amino acids; 108296 Da
Cofactor: Magnesium (By similarity)
Subunit: Homodimer; forms dimers through the leucine-zipper motif. Interacts with the C-terminus of MAPK8IP1 through
the kinase catalytic domain. Binds PRDX3. Associates with the IKK complex through the kinase domain
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein
Sequence caution: Sequence=AAI11727.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAG59505.1;
Type=Erroneous termination; Positions=740; Note=Translated as Tyr;
Secondary accessions: B2R6U2 B4DLE3 B4DMV2 B4DZJ4 D3DNU1 Q05BY6 Q15450 Q2NKN3
Alternative splicing: 5 isoforms:  O43283-1   O43283-3   O43283-4   O43283-5   O43283-6   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP3K13: NX_O43283

Post-translational modifications:

  • Autophosphorylated on serine and threonine residues1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43283

    • 4/28 DME Specific Peptides for MAP3K13 (O43283) (see all 28)
     IGKAYST  STFSSEN  LMHLDIA  WMAPEVI 

    MAP3K13 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001229243.1  NP_001229246.1  NP_004712.1  

    ENSEMBL proteins: 
     ENSP00000392223   ENSP00000411483   ENSP00000405233   ENSP00000389495   ENSP00000399910  
     ENSP00000412037   ENSP00000390323   ENSP00000405163   ENSP00000409325   ENSP00000389798  
     ENSP00000265026   ENSP00000403561   ENSP00000407361   ENSP00000415712   ENSP00000439257  

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    Uscn Proteins for MAP3K13

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0008385colocalizes with IkappaB kinase complex IDA12492477
    GO:0016020membrane IDA9353328


    MAP3K13 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for MAP3K13 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAP3K13 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR017419 MAP3K12_MAP3K13

    Graphical View of Domain Structure for InterPro Entry O43283

    ProtoNet protein and cluster: O43283

    UniProtKB/Swiss-Prot: M3K13_HUMAN, O43283
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for MAP3K13 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: M3K13_HUMAN, O43283
    Function: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically
    with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves
    activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by autophosphorylation and homodimerization

         Genatlas biochemistry entry for MAP3K13:
    mitogen activated protein (MAP/ERK) kinase kinase kinase 13,mixed lineage kinase family,most strongly expressed in
    pancreas

    Enzyme Numbers (IUBMB): EC 2.7.11.251 2 EC 2.7.112

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    hsa-miR-579 hsa-miR-106a hsa-miR-3916 hsa-miR-149 hsa-miR-3116 hsa-miR-200b hsa-miR-4326 hsa-miR-130b
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    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA9353328
    GO:0004709MAP kinase kinase kinase activity IDA11726277
    GO:0005515protein binding IPI12492477


    MAP3K13 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for MAP3K13:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 
     Decreased substrate adherent c 


    Pathways & Interactions
    for MAP3K13 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signal transduction_JNK pathway
    		Signal transduction_JNK pathway1.00
    		Signal transduction JNK pathway0.98
    2MAPK signaling pathway
    		MAPK signaling pathway1.00
    		MAPK signaling pathway0.50
    3NFAT and Cardiac Hypertrophy
    		NFAT and Cardiac Hypertrophy1.00
    4Integrated Breast Cancer Pathway
    		Integrated Breast Cancer Pathway1.00
    5Insulin Signaling
    		Insulin Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for MAP3K13
        Signal transduction JNK pathway

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP3K13
        PACAP Signaling
    TNFR2 Pathway
    NFAT and Cardiac Hypertrophy
    WNT Signaling
    MAPK Family Pathway

    1 GeneGo (Thomson Reuters) Pathway for MAP3K13
        Signal transduction JNK pathway

    4 BioSystems Pathways for MAP3K13 
        Integrated Breast Cancer Pathway
    MAPK signaling pathway
    Insulin Signaling
    Signaling events mediated by VEGFR1 and VEGFR2


    1         Kegg Pathway  (Kegg details for MAP3K13):
        MAPK signaling pathway


    MAP3K13 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP3K13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for MAP3K13 (O432831, 2, 3 ENSP000002650264) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K13O432831, 2EBI-1168480,EBI-1168480 MINT-15420
    PRDX3P300483, ENSP000002985104I2D: score=3 STRING: ENSP00000298510
    MAPK8IP1Q9UQF23, ENSP000002410144I2D: score=2 STRING: ENSP00000241014
    MAP2K7O147333, ENSP000003810664I2D: score=1 STRING: ENSP00000381066
    IKBKBO149203, ENSP000003391514I2D: score=3 STRING: ENSP00000339151
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity IDA11726277
    GO:0006468protein phosphorylation IDA9353328
    GO:0007254JNK cascade IDA11726277
    GO:0046777protein autophosphorylation IDA9353328
    GO:0051092positive regulation of NF-kappaB transcription factor activity IDA12492477


    MAP3K13 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAP3K13 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP3K13 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MAP3K13

    3 HMDB Compounds for MAP3K13    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    8 Novoseek chemical compound relationships for MAP3K13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kt 7515 93.5 4 12376548 (1), 12388555 (1), 11416147 (1), 12421372 (1)
    leucine 65 19 9353328 (2), 11163770 (2), 12186766 (2), 11726277 (1) (see all 10)
    threonine 50.9 5 9353328 (2), 19801649 (1), 15923109 (1)
    serine 44.1 5 9353328 (2), 19801649 (1), 15923109 (1)
    isoleucine 32.7 1 9353328 (1)
    ceramide 28 8 12504027 (2), 12738796 (1)
    tyrosine 13.5 7 9353328 (1), 7493928 (1), 19146952 (1)
    atp 0 1 9353328 (1)

    Search CenterWatch for drugs/clinical trials and news about MAP3K13 / M3K13 

    Transcripts
    for MAP3K13 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAP3K13 gene (3 alternative transcripts): 
    NM_001242314.1  NM_001242317.1  NM_004721.4  

    Unigene Clusters for MAP3K13:

    Mitogen-activated protein kinase kinase kinase 13
    Hs.591306  [show with all ESTs], Hs.634586  [show with all ESTs]
    Unigene Representative Sequences: NR_038322, NM_004721
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000448876(uc003fpg.4) ENST00000446828 ENST00000455188 ENST00000447637
    ENST00000424227 ENST00000454237 ENST00000438798 ENST00000428617 ENST00000443863
    ENST00000433092(uc003fph.4) ENST00000265026(uc010hyf.3 uc011brt.2 uc011bru.2 uc003fpi.3 uc010hyg.3)
    ENST00000438053 ENST00000439882 ENST00000477582 ENST00000420577 ENST00000535426


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    hsa-miR-579 hsa-miR-106a hsa-miR-3916 hsa-miR-149 hsa-miR-3116 hsa-miR-200b hsa-miR-4326 hsa-miR-130b
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    Inhib. RNA
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    Additional cDNA sequence: 

    AB001872.1 AK022438.1 AK123148.1 AK296961.1 AK297646.1 AK302951.1 AK312714.1 BC026249.1 
    BC031677.1 BC111726.1 Z25428.1 

    19 DOTS entries:

    DT.87009426  DT.97843535  DT.100784730  DT.111215  DT.100776033  DT.40130980  DT.40218505  DT.40125793 
    DT.95312889  DT.100784725  DT.91647740  DT.40286271  DT.120870473  DT.75161978  DT.92063202  DT.91659297 
    DT.100776332  DT.92002595  DT.97843536 

    24/208 AceView cDNA sequences (see all 208):

    W60314 BM714466 BM744765 CA866752 AB001872 BM930208 BF110503 CD515594 
    AA327266 AA328993 BQ778298 H29393 AI131049 BM977241 AI422252 BF732540 
    AA015693 AA307292 AI288937 AA909144 AI521914 NM_004721 BM978472 BF109890 

    GeneLoc Exon Structure


    Expression
    for MAP3K13 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP3K13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAGAACATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MAP3K13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP3K13

    SOURCE GeneReport for Unigene clusters: Hs.591306 Hs.634586

    UniProtKB/Swiss-Prot: M3K13_HUMAN, O43283
    Tissue specificity: Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the
    pancreas

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    In Situ
    Assay Products:     
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    Orthologs
    for MAP3K13 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAP3K13 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAP3K131 mitogen-activated protein kinase kinase kinase 13 76.62(n)
    82.02(a)    		   424876  XM_422689.3  XP_422689.3 
    lizard
    (Anolis carolinensis)    		 Reptilia MAP3K136
    		 --
    		 79(a)
    		 1 ↔ 1
    		 3(34459994-34482285)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-45c16.21 si:ch211-45c16.2 68.14(n)
    74.33(a)    		   568412  XM_691738.5  XP_696830.5 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG87893 protein amino acid phosphorylation protein
    kinase    		 62(a)   76B9   --
    worm
    (Caenorhabditis elegans)    		 Secernentea dlk-16
    zak-16
    		 Mitogen-activated protein kinase kinase kinase dlk...
    mammalian ZAK kinase homolog family member (zak-1)...
    		 27(a)
    16(a)
    		 1 ↔ many
    possible ortholog
    		 I(12565789-12572791)
    III(6853054-6856750)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G066306
    AT1G678906
    (see all 12)    		 PAS domain-containing protein tyrosine kinase
    (see all 12)    		 14(a)
    14(a)
    (see all 12)    		 possible ortholog
    possible ortholog
    (see all 12)    		 3(2070388-2073800)
    1(25457179-25462792)
    rice
    (Oryza sativa)    		 Liliopsida AK060220.12   -- 74.34(n)    AK060220.1 


    ENSEMBL Gene Tree for MAP3K13 (if available)
    TreeFam Gene Tree for MAP3K13 (if available) 

    Paralogs
    for MAP3K13 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP3K13 gene
    MAP3K112  MAP3K122  KIAA18042  RAF12  KSR22  KSR12  MOS2  BRAF2  
    MAP3K102  MAP3K92  ARAF2  MAP3K72  MAP3K7CL2  TNNI3K2  ZAK2  ILK2  
    10 SIMAP similar genes for MAP3K13 using alignment to 6 protein entries:     M3K13_HUMAN (see all proteins):
    MAP3K12    MAP3K11    MARK4    MAP3K9    EPHA2    MST094
    pk    FGR    RPS6KA2    tec

    MAP3K13 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MAP3K13
    PGOHUM00000232668


    Genomic Variants
    for MAP3K13 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3409 NCBI SNPs in MAP3K13 are shown (see all 3409)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs76178871,2
    		C,F,--184998811(+) TTCTAT/CGGAAC 3 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1116158541,2
    		--184998915(+) TAAGAC/ACTGCG 3 -- us2k12Minor allele frequency- A:0.03CSA WA 120
    rs1809428961,2
    		--184999173(+) CTCTGA/TCATAT 3 -- us2k10--------
    rs1860544561,2
    		--184999410(+) GAAATA/GCTGTG 3 -- us2k10--------
    rs1909614081,2
    		--184999442(+) ACACCA/GAACAT 3 -- us2k10--------
    rs1832244941,2
    		--184999460(+) TTCATC/TACAAT 3 -- us2k10--------
    rs1463584781,2
    		--184999462(+) CATCAC/GAATTA 3 -- us2k10--------
    rs1397710491,2
    		--184999484(+) GGTTAC/TATTGC 3 -- us2k10--------
    rs738878541,2
    		C,--184999566(+) CCCTTT/ACCTTA 3 -- us2k11Minor allele frequency- A:0.50WA 2
    rs779024241,2
    		F,--184999671(+) TTAGAC/TGCTTC 3 -- us2k11Minor allele frequency- T:0.08EA 120

    HapMap Linkage Disequilibrium report for MAP3K13 (185000729 - 185206885 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for MAP3K13
         2 CNVs: 38483 6223

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP3K13
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP3K13

    Disorders / Diseases
    for MAP3K13 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAP3K13 for disorders           About GeneDecksing

    OMIM gene information: 604915    OMIM disorders: --

    10 diseases for MAP3K13:    About MalaCards
    differentiating neuroblastoma    neurodegenerative disease    huntington's disease    parkinson's disease
    neurodegeneration    breast carcinoma    neuroblastoma    carcinoma
    leukemia    neuronitis

    1 disease from the University of Copenhagen DISEASES database for MAP3K13:
    Parkinson's disease

    3 Novoseek disease relationships for MAP3K13 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurodegenerative diseases 27.9 1 15923109 (1)
    necrosis 0 2 12738796 (1), 15904918 (1)
    tumors 0 2 12738796 (1), 15904918 (1)

    Human Genome Epidemiology (HuGE) Navigator: MAP3K13 (1 document)

    Export disorders for MAP3K13 gene to outside databases

    Publications
    for MAP3K13 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP3K13 gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with MAP3K13)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain. (PubMed id 9353328)1, 2, 3, 9 Sakuma H.... Kawasaki T. (1997)
    2. Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. (PubMed id 11726277)1, 2, 9 Ikeda A.... Kawasaki T. (2001)
    3. Identification and characterization of functional domains in a mixed lineage kinase LZK. (PubMed id 11163770)1, 2, 9 Ikeda A.... Kawasaki T. (2001)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically. (PubMed id 12492477)1, 2 Masaki M.... Kawasaki T. (2003)
    7. Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. (PubMed id 8274451)1, 2 Schultz S.J. and Nigg E.A. (1993)
    8. Genomic organization and fine-mapping of the human leucine zipper-bearing kinase (LZK) gene. (PubMed id 12186766)1, 9 Ikeda A....Kawasaki T. (2002)
    9. Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. (PubMed id 22837378)1 Wilk J.B....Stricker B.H. (2012)
    10. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)1 Toyoshima M....Grandori C. (2012)

    External Searches for MAP3K13 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAP3K13 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9175 HGNC: 6852 AceView: MAP3K13 Ensembl:ENSG00000073803 euGenes: HUgn9175
    ECgene: MAP3K13 Kegg: 9175 H-InvDB: MAP3K13

    Other Databases showing MAP3K13 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAP3K13 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP3K13 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MAP3K13 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAP3K13 gene:
    Search GeneIP for patents involving MAP3K13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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