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MAP3K13 Gene

protein-coding   GIFtS: 65
GCID: GC03P185000

Mitogen-Activated Protein Kinase Kinase Kinase 13

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 131 2     MLK2 3
Leucine Zipper-Bearing Kinase1 2 3     EC 2.7.11.253 8
LZK2 3 5     MEKK132
Mixed Lineage Kinase2 3     EC 2.7.118

External Ids:    HGNC: 68521   Entrez Gene: 91752   Ensembl: ENSG000000738037   OMIM: 6049155   UniProtKB: O432833   

Export aliases for MAP3K13 gene to outside databases

Previous GC identifers: GC03P181938 GC03P186229 GC03P186482 GC03P186401 GC03P186563 GC03P182490


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP3K13 Gene:
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a
dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This
kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway.
(provided by RefSeq, Jul 2008)

GeneCards Summary for MAP3K13 Gene:
MAP3K13 (mitogen-activated protein kinase kinase kinase 13) is a protein-coding gene. Diseases associated with MAP3K13 include differentiating neuroblastoma, and neuroblastoma. GO annotations related to this gene include protein serine/threonine kinase activity and protein homodimerization activity. An important paralog of this gene is FPGT-TNNI3K.

UniProtKB/Swiss-Prot: M3K13_HUMAN, O43283
Function: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts
synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is
kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates
inhibitors of NF-kappa-B

Gene Wiki entry for MAP3K13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP3K13 gene promoter:
         Sox5   AP-1   ATF-2   FOXO3   HNF-1A   HNF-1   FOXJ2 (long isoform)   c-Jun   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP3K13 promoter sequence
   Search Chromatin IP Primers for MAP3K13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP3K13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27   Ensembl cytogenetic band:  3q27.2   HGNC cytogenetic band: 3q27

MAP3K13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K13 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P185000:  view genomic region     (about GC identifiers)

Start:
185,000,729 bp from pter      End:
185,206,885 bp from pter
Size:
206,157 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: M3K13_HUMAN, O43283 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 13  
Size: 966 amino acids; 108296 Da
Cofactor: Magnesium (By similarity)
Subunit: Homodimer; forms dimers through the leucine-zipper motif. Interacts with the C-terminus of MAPK8IP1
through the kinase catalytic domain. Binds PRDX3. Associates with the IKK complex through the kinase domain
Sequence caution: Sequence=AAI11727.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=BAG59505.1;
Type=Erroneous termination; Positions=740; Note=Translated as Tyr;
Secondary accessions: B2R6U2 B4DLE3 B4DMV2 B4DZJ4 D3DNU1 Q05BY6 Q15450 Q2NKN3
Alternative splicing: 5 isoforms:  O43283-1   O43283-3   O43283-4   O43283-5   O43283-6   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP3K13: NX_O43283

Explore proteomics data for MAP3K13 at MOPED

Post-translational modifications: 

  • Autophosphorylated on serine and threonine residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAP3K13 (O43283) (see all 28)
     IGKAYST  STFSSEN  LMHLDIA  WMAPEVI 


    See MAP3K13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001229243.1  NP_001229246.1  NP_004712.1  

    ENSEMBL proteins: 
     ENSP00000392223   ENSP00000411483   ENSP00000405233   ENSP00000389495   ENSP00000399910  
     ENSP00000412037   ENSP00000390323   ENSP00000405163   ENSP00000389798   ENSP00000409325  
     ENSP00000265026   ENSP00000403561   ENSP00000407361   ENSP00000415712   ENSP00000439257  

    MAP3K13 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAP3K: Mitogen-activated protein kinase cascade / Kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase 13
    LZK subfamily

    Selected InterPro protein domains (see all 6):
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom
     IPR027258 MAPKKK13
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry O43283

    ProtoNet protein and cluster: O43283

    UniProtKB/Swiss-Prot: M3K13_HUMAN, O43283
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain


    MAP3K13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M3K13_HUMAN, O43283
    Function: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts
    synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is
    kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates
    inhibitors of NF-kappa-B
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by autophosphorylation and homodimerization

         Genatlas biochemistry entry for MAP3K13:
    mitogen activated protein (MAP/ERK) kinase kinase kinase 13,mixed lineage kinase family,most strongly expressed in
    pancreas

         Enzyme Numbers (IUBMB): EC 2.7.11.251 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA9353328
    GO:0004709MAP kinase kinase kinase activity IDA11726277
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI11726277
         
    MAP3K13 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for MAP3K13:
     Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella enterica   Decreased Salmonella-containin 
     Decreased substrate adherent c 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target MAP3K13:
    hsa-mir-93-5p (MIRT048810)

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    Selected qRT-PCR Assays for microRNAs that regulate MAP3K13 (see all 136):
    hsa-miR-579 hsa-miR-106a hsa-miR-3916 hsa-miR-149 hsa-miR-3116 hsa-miR-200b hsa-miR-4326 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidMAP3K13 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MAP3K13

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    M3K13_HUMAN, O43283: Cytoplasm. Membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008385colocalizes with IkappaB kinase complex IDA12492477
    GO:0016020membrane IDA9353328

    MAP3K13 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP3K13 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2TGF-Beta Pathway
    MAPK Family Pathway0.60
    3TNF Signaling
    Death Receptor Signaling0.50
    4NFAT and Cardiac Hypertrophy
    NFAT and Cardiac Hypertrophy0.42
    5Signaling events mediated by VEGFR1 and VEGFR2
    Signaling events mediated by VEGFR1 and VEGFR20.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAP3K13
        PACAP Signaling
    TNFR2 Pathway
    NFAT and Cardiac Hypertrophy
    WNT Signaling
    MAPK Family Pathway

    1 GeneGo (Thomson Reuters) Pathway for MAP3K13
        Signal transduction JNK pathway

    4 BioSystems Pathways for MAP3K13
        MAPK signaling pathway
    Insulin Signaling
    Integrated Breast Cancer Pathway
    Signaling events mediated by VEGFR1 and VEGFR2

    1 Sino Biological Pathway for MAP3K13
        Death Receptor Signaling


    1 Kegg Pathway  (Kegg details for MAP3K13):
        MAPK signaling pathway


    MAP3K13 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAP3K13
    Interactions:

        GeneGlobe Interaction Network for MAP3K13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for MAP3K13 (O432831, 2, 3 ENSP000002650264) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K13O432831, 2EBI-1168480,EBI-1168480 MINT-15420
    PRDX3P300483, ENSP000002985104I2D: score=3 STRING: ENSP00000298510
    MAPK8IP1Q9UQF23, ENSP000002410144I2D: score=2 STRING: ENSP00000241014
    MAP2K7O147333, ENSP000003810664I2D: score=1 STRING: ENSP00000381066
    IKBKBO149203, ENSP000003391514I2D: score=3 STRING: ENSP00000339151
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity IDA11726277
    GO:0006468protein phosphorylation IDA11726277
    GO:0007254JNK cascade IDA11726277
    GO:0046777protein autophosphorylation IDA9353328
    GO:0051092positive regulation of NF-kappaB transcription factor activity IDA12492477

    MAP3K13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAP3K13 (M3K13)

    3 HMDB Compounds for MAP3K13    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    8 Novoseek inferred chemical compound relationships for MAP3K13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kt 7515 93.5 4 12376548 (1), 12388555 (1), 11416147 (1), 12421372 (1)
    leucine 65 19 9353328 (2), 11163770 (2), 12186766 (2), 11726277 (1) (see all 10)
    threonine 50.9 5 9353328 (2), 19801649 (1), 15923109 (1)
    serine 44.1 5 9353328 (2), 19801649 (1), 15923109 (1)
    isoleucine 32.7 1 9353328 (1)
    ceramide 28 8 12504027 (2), 12738796 (1)
    tyrosine 13.5 7 9353328 (1), 7493928 (1), 19146952 (1)
    atp 0 1 9353328 (1)



    MAP3K13 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAP3K13 gene (3 alternative transcripts): 
    NM_001242314.1  NM_001242317.1  NM_004721.4  

    Unigene Clusters for MAP3K13:

    Mitogen-activated protein kinase kinase kinase 13
    Hs.591306  [show with all ESTs], Hs.634586  [show with all ESTs]
    Unigene Representative Sequences: NR_038322, NM_004721
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000448876(uc003fpg.4) ENST00000446828 ENST00000455188 ENST00000447637
    ENST00000424227 ENST00000454237 ENST00000438798 ENST00000428617 ENST00000433092(uc003fph.4)
    ENST00000443863 ENST00000265026(uc010hyf.3 uc011brt.2 uc011bru.2 uc003fpi.3 uc010hyg.3)
    ENST00000438053 ENST00000439882 ENST00000477582 ENST00000420577 ENST00000535426

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    Selected qRT-PCR Assays for microRNAs that regulate MAP3K13 (see all 136):
    hsa-miR-579 hsa-miR-106a hsa-miR-3916 hsa-miR-149 hsa-miR-3116 hsa-miR-200b hsa-miR-4326 hsa-miR-130b
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    Additional mRNA sequence: 

    AB001872.1 AK022438.1 AK123148.1 AK296961.1 AK297646.1 AK302951.1 AK312714.1 BC026249.1 
    BC031677.1 BC111726.1 Z25428.1 

    19 DOTS entries:

    DT.87009426  DT.97843535  DT.100784730  DT.111215  DT.100776033  DT.40130980  DT.40218505  DT.40125793 
    DT.95312889  DT.100784725  DT.91647740  DT.40286271  DT.120870473  DT.75161978  DT.92063202  DT.91659297 
    DT.100776332  DT.92002595  DT.97843536 

    Selected AceView cDNA sequences (see all 208):

    AA781074 BM683597 AA909144 AW301584 CR614418 AI271719 BF445861 BE671534 
    AI719432 CD237050 BM978472 NM_004721 BF593297 AA015693 H29393 W60314 
    BM977241 AI422252 AA054171 BF109890 BF732540 BM873461 AI521914 BC031677 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAP3K13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGAACATA
    MAP3K13 Expression
    About this image

    MAP3K13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP3K13 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.591306 Hs.634586

    UniProtKB/Swiss-Prot: M3K13_HUMAN, O43283
    Tissue specificity: Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the
    pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAP3K13 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map3k131 , 5 mitogen-activated protein kinase kinase kinase 131, 5 84.78(n)1
    89.26(a)1
      16 (12.92 cM)5
    717511  NM_172821.31  NP_766409.21 
     218919695 
    chicken
    (Gallus gallus)
    Aves MAP3K131 mitogen-activated protein kinase kinase kinase 13 76.41(n)
    81.81(a)
      424876  XM_422689.4  XP_422689.3 
    lizard
    (Anolis carolinensis)
    Reptilia MAP3K136
    mitogen-activated protein kinase kinase kinase 13
    79(a)
    1 ↔ 1
    3(34459994-34482303)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004938781 mitogen-activated protein kinase kinase kinase 13-A-like 69.4(n)
    74.89(a)
      100493878  XM_002936531.2  XP_002936577.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-45c16.21 si:ch211-45c16.2 67.94(n)
    73.87(a)
      568412  XM_691738.6  XP_696830.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG87893 protein amino acid phosphorylation
    protein kinase
    62(a)   76B9   --
    worm
    (Caenorhabditis elegans)
    Secernentea dlk-16
    Protein DLK-1, isoform a
    31(a)
    1 → many
    I(12565799-12572801) WBGene00001008
    rice
    (Oryza sativa)
    Liliopsida AK060220.12   -- 74.34(n)    AK060220.1 


    ENSEMBL Gene Tree for MAP3K13 (if available)
    TreeFam Gene Tree for MAP3K13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP3K13 gene
    FPGT-TNNI3K2  MAP3K122  MAP3K112  KIAA18042  RAF12  KSR22  KSR12  MOS2  
    BRAF2  MAP3K92  MAP3K102  ARAF2  MAP3K72  TNNI3K2  ZAK2  ILK2  
    11 SIMAP similar genes for MAP3K13 using alignment to 6 protein entries:     M3K13_HUMAN (see all proteins):
    MAP3K12    MAP3K10    MAP3K11    MARK4    MAP3K9    EPHA2
    MST094    pk    FGR    RPS6KA2    tec

    MAP3K13 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MAP3K13
    PGOHUM00000232668


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP3K13 (see all 3983)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0407104
    A metastatic melanoma sample4--see VAR_0407102 P L mis40--------
    rs725919901,2
    C--182468147(+) AAGTT-/AC/CA 
            
    ATTCT
    2 -- int11CSA 2
    rs76178871,2
    C,F--184998811(+) TTCTAT/CGGAAC 3 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1116158541,2
    C,F--184998915(+) TAAGAC/ACTGCG 3 -- us2k12Minor allele frequency- A:0.03CSA WA 120
    rs1809428961,2
    --184999173(+) CTCTGA/TCATAT 3 -- us2k10--------
    rs1860544561,2
    --184999410(+) GAAATA/GCTGTG 3 -- us2k10--------
    rs1909614081,2
    --184999442(+) ACACCA/GAACAT 3 -- us2k10--------
    rs1832244941,2
    --184999460(+) TTCATC/TACAAT 3 -- us2k10--------
    rs1463584781,2
    C--184999462(+) CATCAC/GAATTA 3 -- us2k10--------
    rs1397710491,2
    --184999484(+) GGTTAC/TATTGC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAP3K13 (185000729 - 185206885 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAP3K13 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659506CNV Deletion23128226
    esv2339714CNV Deletion18987734
    esv2545135CNV Deletion19546169
    esv2726325CNV Deletion23290073
    esv1742989CNV Deletion17803354
    esv3258CNV Deletion18987735
    esv1687636CNV Insertion17803354
    esv7825CNV Loss19470904
    nsv829818CNV Loss17160897
    nsv237556CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP3K13
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP3K13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604915    OMIM disorders: --

    7 diseases for MAP3K13:    
    About MalaCards
    differentiating neuroblastoma    neuroblastoma    huntington's disease    parkinson's disease
    leukemia    breast cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for MAP3K13:
    Parkinson's disease

    MAP3K13 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for MAP3K13 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurodegenerative diseases 27.9 1 15923109 (1)
    necrosis 0 2 12738796 (1), 15904918 (1)
    tumors 0 2 12738796 (1), 15904918 (1)

    Genetic Association Database (GAD): MAP3K13
    Human Genome Epidemiology (HuGE) Navigator: MAP3K13 (1 document)

    Export disorders for MAP3K13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP3K13 gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with MAP3K13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain. (PubMed id 9353328)1, 2, 3, 9 Sakuma H.... Kawasaki T. (J. Biol. Chem. 1997)
    2. Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. (PubMed id 11726277)1, 2, 9 Ikeda A.... Kawasaki T. (J. Biochem. 2001)
    3. Identification and characterization of functional domains in a mixed lineage kinase LZK. (PubMed id 11163770)1, 2, 9 Ikeda A.... Kawasaki T. (FEBS Lett. 2001)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically. (PubMed id 12492477)1, 2 Masaki M.... Kawasaki T. (Eur. J. Biochem. 2003)
    8. Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. (PubMed id 8274451)1, 2 Schultz S.J. and Nigg E.A. (Cell Growth Differ. 1993)
    9. Genomic organization and fine-mapping of the human leucine zipper-bearing kinase (LZK) gene. (PubMed id 12186766)1, 9 Ikeda A....Kawasaki T. (J. Biochem. Mol. Biol. Biophys. 2002)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9175 HGNC: 6852 AceView: MAP3K13 Ensembl:ENSG00000073803 euGenes: HUgn9175
    ECgene: MAP3K13 Kegg: 9175 H-InvDB: MAP3K13

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAP3K13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAP3K13 gene:
    Search GeneIP for patents involving MAP3K13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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