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Aliases for MAP3K13 Gene

Aliases for MAP3K13 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 13 2 3
  • Leucine Zipper-Bearing Kinase 2 3 4
  • Mixed Lineage Kinase 3 4
  • EC 2.7.11.25 4 63
  • LZK 3 4
  • MLK 3 4
  • EC 2.7.11 63
  • MEKK13 3

External Ids for MAP3K13 Gene

Previous GeneCards Identifiers for MAP3K13 Gene

  • GC03P181938
  • GC03P186229
  • GC03P186482
  • GC03P186401
  • GC03P186563
  • GC03P185000
  • GC03P182490

Summaries for MAP3K13 Gene

Entrez Gene Summary for MAP3K13 Gene

  • The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK signaling pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP3K13 Gene

MAP3K13 (Mitogen-Activated Protein Kinase Kinase Kinase 13) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is MAP3K9.

UniProtKB/Swiss-Prot for MAP3K13 Gene

  • Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.

Gene Wiki entry for MAP3K13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K13 Gene

Genomics for MAP3K13 Gene

Regulatory Elements for MAP3K13 Gene

Genomic Location for MAP3K13 Gene

Chromosome:
3
Start:
185,282,941 bp from pter
End:
185,489,097 bp from pter
Size:
206,157 bases
Orientation:
Plus strand

Genomic View for MAP3K13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP3K13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K13 Gene

Proteins for MAP3K13 Gene

  • Protein details for MAP3K13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43283-M3K13_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 13
    Protein Accession:
    O43283
    Secondary Accessions:
    • B2R6U2
    • B4DLE3
    • B4DMV2
    • B4DZJ4
    • D3DNU1
    • Q05BY6
    • Q15450
    • Q2NKN3

    Protein attributes for MAP3K13 Gene

    Size:
    966 amino acids
    Molecular mass:
    108296 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer; forms dimers through the leucine-zipper motif. Interacts with the C-terminus of MAPK8IP1 through the kinase catalytic domain. Binds PRDX3. Associates with the IKK complex through the kinase domain.
    SequenceCaution:
    • Sequence=AAI11727.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAG59505.1; Type=Erroneous termination; Positions=740; Note=Translated as Tyr.; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP3K13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP3K13 Gene

Proteomics data for MAP3K13 Gene at MOPED

Post-translational modifications for MAP3K13 Gene

Antibody Products

Domains & Families for MAP3K13 Gene

Suggested Antigen Peptide Sequences for MAP3K13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43283

UniProtKB/Swiss-Prot:

M3K13_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K13: view

Function for MAP3K13 Gene

Molecular function for MAP3K13 Gene

GENATLAS Biochemistry:
mitogen activated protein (MAP/ERK) kinase kinase kinase 13,mixed lineage kinase family,most strongly expressed in pancreas
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by autophosphorylation and homodimerization.
UniProtKB/Swiss-Prot Function:
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.

Enzyme Numbers (IUBMB) for MAP3K13 Gene

Gene Ontology (GO) - Molecular Function for MAP3K13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 9353328
GO:0004709 MAP kinase kinase kinase activity IDA 11726277
GO:0005515 protein binding IPI 11726277
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MAP3K13: view
genes like me logo Genes that share phenotypes with MAP3K13: view

Animal Model Products

CRISPR Products

miRNA for MAP3K13 Gene

miRTarBase miRNAs that target MAP3K13

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP3K13

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for MAP3K13 Gene

Localization for MAP3K13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP3K13 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP3K13 Gene COMPARTMENTS Subcellular localization image for MAP3K13 gene
Compartment Confidence
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MAP3K13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0008385 colocalizes_with IkappaB kinase complex IDA 12492477
GO:0016020 membrane IDA 9353328
genes like me logo Genes that share ontologies with MAP3K13: view

Pathways & Interactions for MAP3K13 Gene

genes like me logo Genes that share pathways with MAP3K13: view

Pathways by source for MAP3K13 Gene

1 KEGG pathway for MAP3K13 Gene
1 GeneGo (Thomson Reuters) pathway for MAP3K13 Gene

SIGNOR curated interactions for MAP3K13 Gene

Activates:

Gene Ontology (GO) - Biological Process for MAP3K13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IDA 11726277
GO:0006468 protein phosphorylation IDA 9353328
GO:0007254 JNK cascade IDA 9353328
GO:0046777 protein autophosphorylation IDA 9353328
GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA 12492477
genes like me logo Genes that share ontologies with MAP3K13: view

Drugs & Compounds for MAP3K13 Gene

(8) Drugs for MAP3K13 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0
ATP Pharma Activator 0
isoleucine Nutra 14
leucine Nutra 93

(3) Additional Compounds for MAP3K13 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
Ceramide
3102-57-6
KT 7515
genes like me logo Genes that share compounds with MAP3K13: view

Transcripts for MAP3K13 Gene

Unigene Clusters for MAP3K13 Gene

Mitogen-activated protein kinase kinase kinase 13:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP3K13

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K13 Gene

No ASD Table

Relevant External Links for MAP3K13 Gene

GeneLoc Exon Structure for
MAP3K13
ECgene alternative splicing isoforms for
MAP3K13

Expression for MAP3K13 Gene

mRNA expression in normal human tissues for MAP3K13 Gene

Protein differential expression in normal tissues from HIPED for MAP3K13 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAP3K13 Gene



SOURCE GeneReport for Unigene cluster for MAP3K13 Gene Hs.591306

mRNA Expression by UniProt/SwissProt for MAP3K13 Gene

O43283-M3K13_HUMAN
Tissue specificity: Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas.
genes like me logo Genes that share expression patterns with MAP3K13: view

Protein tissue co-expression partners for MAP3K13 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MAP3K13 Gene

Orthologs for MAP3K13 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP3K13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAP3K13 35
  • 91.37 (n)
  • 93.79 (a)
MAP3K13 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP3K13 35
  • 91.34 (n)
  • 93.27 (a)
MAP3K13 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map3k13 35
  • 84.78 (n)
  • 89.26 (a)
Map3k13 16
Map3k13 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAP3K13 35
  • 99.14 (n)
  • 98.96 (a)
MAP3K13 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map3k13 35
  • 84.36 (n)
  • 88.19 (a)
oppossum
(Monodelphis domestica)
Mammalia MAP3K13 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP3K13 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP3K13 35
  • 76.41 (n)
  • 81.81 (a)
MAP3K13 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP3K13 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493878 35
  • 69.4 (n)
  • 74.89 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-45c16.2 35
  • 67.94 (n)
  • 73.87 (a)
MAP3K13 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8789 37
  • 62 (a)
wnd 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dlk-1 36
  • 31 (a)
OneToMany
Species with no ortholog for MAP3K13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP3K13 Gene

ENSEMBL:
Gene Tree for MAP3K13 (if available)
TreeFam:
Gene Tree for MAP3K13 (if available)

Paralogs for MAP3K13 Gene

(11) SIMAP similar genes for MAP3K13 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for MAP3K13 Gene

genes like me logo Genes that share paralogs with MAP3K13: view

Variants for MAP3K13 Gene

Sequence variations from dbSNP and Humsavar for MAP3K13 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs10150 -- 185,291,817(-) AGTCA(G/T)AGGAA intron-variant, nc-transcript-variant
rs496794 -- 185,471,876(+) tcctg(A/T)tacaa intron-variant
rs667526 -- 185,465,630(+) TTAAA(C/G)TAAGA intron-variant
rs894276 -- 185,440,621(-) TGCCA(C/T)AAAGC intron-variant
rs1017501 -- 185,434,325(-) ACTGC(C/T)GGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP3K13 Gene

Variant ID Type Subtype PubMed ID
nsv829817 CNV Gain 17160897
dgv5355n71 CNV Gain 21882294
esv2545135 CNV Deletion 19546169
esv2339714 CNV Deletion 18987734
esv3258 CNV Deletion 18987735
esv7825 CNV Loss 19470904
esv2726325 CNV Deletion 23290073
esv1742989 CNV Deletion 17803354
esv2659506 CNV Deletion 23128226
nsv441852 CNV CNV 18776908
nsv822366 CNV Loss 20364138
nsv237556 CNV Loss 16902084
nsv829818 CNV Loss 17160897
esv1687636 CNV Insertion 17803354

Variation tolerance for MAP3K13 Gene

Residual Variation Intolerance Score: 13.53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP3K13 Gene

HapMap Linkage Disequilibrium report
MAP3K13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K13 Gene

Disorders for MAP3K13 Gene

Relevant External Links for MAP3K13

Genetic Association Database (GAD)
MAP3K13
Human Genome Epidemiology (HuGE) Navigator
MAP3K13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP3K13
genes like me logo Genes that share disorders with MAP3K13: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K13 Gene

Publications for MAP3K13 Gene

  1. Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain. (PMID: 9353328) Sakuma H. … Kawasaki T. (J. Biol. Chem. 1997) 2 23 67
  2. POSH misexpression induces caspase-dependent cell death in Drosophila. (PMID: 20014406) Lennox A.L. … Stronach B. (Dev. Dyn. 2010) 23 67
  3. The mixed-lineage kinase DLK is a key regulator of 3T3-L1 adipocyte differentiation. (PMID: 19270737) Couture J.P. … Blouin R. (PLoS ONE 2009) 23 67
  4. The mixed-lineage kinase DLK undergoes Src-dependent tyrosine phosphorylation and activation in cells exposed to vanadate or platelet-derived growth factor (PDGF). (PMID: 19146952) Daviau A. … Blouin R. (Cell. Signal. 2009) 23 67
  5. Kinase inhibitors as potential therapeutics for acute and chronic neurodegenerative conditions. (PMID: 19751204) Cuny G.D. (Curr. Pharm. Des. 2009) 23 67

Products for MAP3K13 Gene

Sources for MAP3K13 Gene

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