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MAP3K12 Gene

protein-coding   GIFtS: 65
GCID: GC12M053870

Mitogen-Activated Protein Kinase Kinase Kinase 12


(Previous symbol: ZPK)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 121 2     EC 2.7.11.253 8
ZPK1 2 3 5     MEKK122
Dual Leucine Zipper Kinase DLK1 2     ZPKP12
Dual Leucine Zipper Bearing Kinase2 3     Leucine Zipper Protein Kinase2
Mixed Lineage Kinase2 3     Protein Kinase MUK2
DLK2 3     Leucine-Zipper Protein Kinase3
MUK2 3     EC 2.7.118
MAPK-Upstream Kinase2 3     

External Ids:    HGNC: 68511   Entrez Gene: 77862   Ensembl: ENSG000001396257   OMIM: 6004475   UniProtKB: Q128523   
ORGUL members:         

Export aliases for MAP3K12 gene to outside databases

Previous GC identifers: GC12M053986 GC12M053591 GC12M052160 GC12M050914


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP3K12 Gene:
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper
domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic
terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers
with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and
MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively
spliced transcript variants encoding different proteins have been described.(provided by RefSeq, Jul 2010)

GeneCards Summary for MAP3K12 Gene:
MAP3K12 (mitogen-activated protein kinase kinase kinase 12) is a protein-coding gene. Diseases associated with MAP3K12 include ureteral obstruction, and astigmatism. GO annotations related to this gene include protein kinase binding and protein homodimerization activity. An important paralog of this gene is FPGT-TNNI3K.

UniProtKB/Swiss-Prot: M3K12_HUMAN, Q12852
Function: May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic
protein in vitro

Gene Wiki entry for MAP3K12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MAP3K12 gene promoter:
         Sp1   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP3K12 promoter sequence
   Search Chromatin IP Primers for MAP3K12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP3K12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

MAP3K12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K12 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M053870:  view genomic region     (about GC identifiers)

Start:
53,874,274 bp from pter      End:
53,893,847 bp from pter
Size:
19,574 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: M3K12_HUMAN, Q12852 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 12  
Size: 859 amino acids; 93219 Da
Cofactor: Magnesium
Subunit: Interacts with MBIP
Secondary accessions: B3KSS9 G3V1Y2 Q86VQ5 Q8WY25
Alternative splicing: 2 isoforms:  Q12852-1   Q12852-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP3K12: NX_Q12852

Explore proteomics data for MAP3K12 at MOPED

Post-translational modifications: 

  • Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when
    membrane-associated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAP3K12 (Q12852) (see all 19)
     IGKAYST  STFSSEN  WMAPEVI  LWELLTGE 


    See MAP3K12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001180440.1  NP_006292.3  

    ENSEMBL proteins: 
     ENSP00000267079   ENSP00000449038   ENSP00000448689   ENSP00000447889   ENSP00000454355  

    MAP3K12 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAP3K: Mitogen-activated protein kinase cascade / Kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase 12
    LZK subfamily

    Selected InterPro protein domains (see all 6):
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR017419 MAP3K12_MAP3K13

    Graphical View of Domain Structure for InterPro Entry Q12852

    ProtoNet protein and cluster: Q12852

    UniProtKB/Swiss-Prot: M3K12_HUMAN, Q12852
    Domain: Interacts with MBIP through the leucine-zipper motif
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain


    MAP3K12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M3K12_HUMAN, Q12852
    Function: May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic
    protein in vitro
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for MAP3K12:
    mitogen activated protein (MAP/ERK) kinase kinase kinase 12,expressed in brain,interacting with the GTP bound form
    of RAC and CDC42,regulators of JNK pathway

         Enzyme Numbers (IUBMB): EC 2.7.11.251 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS8637721
    GO:0004674protein serine/threonine kinase activity ISS--
    GO:0004709MAP kinase kinase kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI16169070
         
    MAP3K12 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for MAP3K12:
     Decreased substrate adherent c  Increased S DNA content  Increased cell death in DLD-1   Increased cell size 
     Increased number of mitotic ce 

         5 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Map3k12):
     cellular  homeostasis/metabolism  mortality/aging  nervous system  vision/eye 

    MAP3K12 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MAP3K12: Map3k12tm1.1Lewc Map3k12tm1Shir Map3K12tm1.2Adia

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAP3K12
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP3K12
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP3K12

    miRNA
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    miRTarBase miRNAs that target MAP3K12:
    hsa-mir-26b-5p (MIRT029590), hsa-mir-17-5p (MIRT003013), hsa-mir-20a-5p (MIRT003010)

    Block miRNA regulation of human, mouse, rat MAP3K12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP3K12 (see all 55):
    hsa-miR-4317 hsa-miR-513a-5p hsa-miR-106a hsa-miR-301a hsa-miR-30d hsa-miR-519a hsa-miR-374a* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidMAP3K12 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAP3K12
    Predesigned siRNA for gene silencing in human, mouse, rat MAP3K12

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    M3K12_HUMAN, Q12852: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane4
    nucleus3
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS8663324
    GO:0005829cytosol ISS--
    GO:0005886plasma membrane ISS--
    GO:0016020membrane ISS9353328
    GO:0030424axon IEA--

    MAP3K12 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP3K12 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2TGF-Beta Pathway
    MAPK Family Pathway0.60
    3G protein signaling Ras family GTPases in kinase cascades scheme
    MAPK Cascade0.44
    4NFAT and Cardiac Hypertrophy
    NFAT and Cardiac Hypertrophy0.42
    5ErbB4 Pathway
    PACAP Signaling0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAP3K12
        PACAP Signaling
    TNFR2 Pathway
    NFAT and Cardiac Hypertrophy
    WNT Signaling
    MAPK Family Pathway

    1 GeneGo (Thomson Reuters) Pathway for MAP3K12
        Signal transduction JNK pathway

    4 BioSystems Pathways for MAP3K12
        MAPK signaling pathway
    Insulin Signaling
    MAPK Cascade
    Regulation of p38-alpha and p38-beta


    1 Kegg Pathway  (Kegg details for MAP3K12):
        MAPK signaling pathway


    MAP3K12 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MAP3K12: 
              Cell Lineage Identification in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAP3K12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for MAP3K12 (Q128521, 2, 3 ENSP000002670794) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FRA10AC1Q70Z531, 2, 3EBI-710223,EBI-710176 MINT-64738 I2D: score=3 
    FTLP027922, 3MINT-63358 I2D: score=4 
    RGS1Q081162, 3MINT-64059 I2D: score=4 
    TSC22D1Q157142, 3MINT-64576 I2D: score=4 
    MAPK6Q166592, 3MINT-8261362 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity ----
    GO:0006468protein phosphorylation ISS--
    GO:0007254JNK cascade ISS9353328
    GO:0016572histone phosphorylation ISS--
    GO:0018105peptidyl-serine phosphorylation ISS--

    MAP3K12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAP3K12 (M3K12)

    3 HMDB Compounds for MAP3K12    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    7 Novoseek inferred chemical compound relationships for MAP3K12 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 69.3 45 11069624 (9), 14739943 (2), 19675578 (2), 8037767 (2) (see all 14)
    threonine 43.9 3 8037767 (1), 11069624 (1)
    okadaic acid 38.4 1 8663324 (1)
    serine 23.4 3 8037767 (1), 11069624 (1)
    cyclic amp 20.2 6 16369771 (4), 10442638 (1)
    retinoic acid 15.4 2 10442638 (2)
    calcium 0 1 8663324 (1)



    MAP3K12 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAP3K12 gene (2 alternative transcripts): 
    NM_001193511.1  NM_006301.3  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000547020 ENST00000267079(uc001sdm.2 uc001sdn.2) ENST00000547488
    ENST00000551511 ENST00000547035 ENST00000552365 ENST00000548690 ENST00000547151
    ENST00000551895 ENST00000547803 ENST00000548565

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    Selected qRT-PCR Assays for microRNAs that regulate MAP3K12 (see all 55):
    hsa-miR-4317 hsa-miR-513a-5p hsa-miR-106a hsa-miR-301a hsa-miR-30d hsa-miR-519a hsa-miR-374a* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidMAP3K12 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat MAP3K12

    Selected AceView cDNA sequences (see all 112):

    AI217632 AW295114 BC050050 BM467946 CA388686 BM460977 AK094195 AW298368 
    BQ028422 BU538613 BU743249 BM550583 AW444664 BF438012 CB164332 CA411906 
    AA258669 BX095794 AA858280 BM930057 AA258279 BF447526 BX435939 AA383035 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K12 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16
    SP1:              -           -                 -                 -                 -                                                               
    SP2:                                            -                 -                 -                                                               
    SP3:              -                             -                 -                 -                                                               
    SP4:                          -     -           -                                                                                                   
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for MAP3K12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAP3K12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATGGCTCA
    MAP3K12 Expression
    About this image


    MAP3K12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Thyroid (Endocrine System)
    MAP3K12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP3K12 Protein Expression

    UniProtKB/Swiss-Prot: M3K12_HUMAN, Q12852
    Tissue specificity: Highly expressed in brain and kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including MAP3K12: 
              Cell Lineage Identification in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat MAP3K12
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for MAP3K12 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map3k121 , 5 mitogen-activated protein kinase kinase kinase 121, 5 90.69(n)1
    96.4(a)1
      15 (57.63 cM)5
    264041  NM_001163643.11  NP_001157115.11 
     1024976495 
    chicken
    (Gallus gallus)
    Aves MAP3K126
    mitogen-activated protein kinase kinase kinase 12
    86(a)
    1 ↔ 1
    AADN03015621.1(21-3899)
    lizard
    (Anolis carolinensis)
    Reptilia MAP3K126
    mitogen-activated protein kinase kinase kinase 12
    76(a)
    1 ↔ 1
    2(73188592-73348674)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia map3k121 mitogen-activated protein kinase kinase kinase 12 67.55(n)
    73.58(a)
      100488307  XM_004911942.1  XP_004911999.1 
    zebrafish
    (Danio rerio)
    Actinopterygii map3k121 mitogen-activated protein kinase kinase kinase 12 71.59(n)
    78.3(a)
      404626  NM_207094.1  NP_996977.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG87893 protein amino acid phosphorylation
    protein kinase
    60(a)   76B9   --
    worm
    (Caenorhabditis elegans)
    Secernentea dlk-16
    Protein DLK-1, isoform a
    27(a)
    1 → many
    I(12565799-12572801) WBGene00001008


    ENSEMBL Gene Tree for MAP3K12 (if available)
    TreeFam Gene Tree for MAP3K12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP3K12 gene
    FPGT-TNNI3K2  ARAF2  MAP3K112  KIAA18042  RAF12  KSR22  MAP3K72  TNNI3K2  
    KSR12  ZAK2  MOS2  MAP3K132  BRAF2  ILK2  MAP3K92  MAP3K102  
    9 SIMAP similar genes for MAP3K12 using alignment to 3 protein entries:     M3K12_HUMAN (see all proteins):
    MAP3K13    ZAK    pk    MAP3K9    MAP3K10    MAP3K11
    EPHA2    MLK4    BMX

    MAP3K12 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP3K12 (see all 377)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0407054
    A breast pleomorphic lobular carcinoma sample4--see VAR_0407052 E K mis40--------
    rs7845641,2
    C,F,H--53875535(+) TACATA/GCAAGC 2 -- int122Minor allele frequency- G:0.16NS EA NA WA CSA 1744
    rs1421266481,2
    --53875741(+) GAAGTG/TCCTGG 4 E A mis10--------
    rs2013325531,2
    --53875769(+) GCTGGA/GTTCAG 4 P S mis10--------
    rs2005044181,2
    --53875883(+) GCCAAC/TTTCAG 4 I V mis10--------
    rs1401314301,2
    C--53875902(+) CTGGGG/CGAAGG 4 /S syn11Minor allele frequency- C:0.00NA 4552
    rs1498765911,2
    C--53875972(+) ACTGGC/TGCATG 4 H R mis11Minor allele frequency- T:0.00NA 4552
    rs1387223741,2
    C--53876055(+) AATGCC/TATTAA 2 -- int10--------
    rs1493424181,2
    C--53876179(+) GGGGGC/G/TTCTGA 2 -- int10--------
    rs1447395441,2
    C--53876183(+) GGTCTA/GATTAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for MAP3K12 (53874274 - 53893847 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MAP3K12:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1293318CNV Deletion17803354
    esv2289574CNV Deletion18987734
    esv992595CNV Deletion20482838
    esv2745908CNV Deletion23290073
    esv2745906CNV Deletion23290073
    nsv714CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP3K12
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP3K12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600447    OMIM disorders: --

    12 diseases for MAP3K12:    
    About MalaCards
    ureteral obstruction    astigmatism    teratocarcinoma    keratitis
    neuronitis    thyroid cancer    ischemia    parkinson's disease
    thyroiditis    endotheliitis    cerebritis    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for MAP3K12:
    Parkinson's disease

    MAP3K12 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for MAP3K12 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    teratocarcinoma 64.5 3 10442638 (1), 16369771 (1)

    Genetic Association Database (GAD): MAP3K12
    Human Genome Epidemiology (HuGE) Navigator: MAP3K12 (2 documents)

    Export disorders for MAP3K12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP3K12 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with MAP3K12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel putative protein kinase having a leucine zipper domain from human brain. (PubMed id 8037767)1, 2, 3, 9 Reddy U.R. and Pleasure D. (Biochem. Biophys. Res. Commun. 1994)
    2. SP3 acts as a positive regulator on the core promoter of human ZPK gene. (PubMed id 14697235)1, 2, 9 Itoh A.... Itoh T. (Biochem. Biophys. Res. Commun. 2004)
    3. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PubMed id 19851984)1, 4 Clague J....Wu X. (Mol. Carcinog. 2010)
    4. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/Dual leucine zipper-bearing kinase/leucine zipper protein kinase. (PubMed id 10801814)1, 2 Fukuyama K.... Ohno S. (J. Biol. Chem. 2000)
    8. Characterization of dual leucine zipper-bearing kinase, a mixed lineage kinase present in synaptic terminals whose phosphorylation state is regulated by membrane depolarization via calcineurin. (PubMed id 8663324)1, 9 Mata M....Holzman L.B. (J. Biol. Chem. 1996)
    9. ZPK inhibits PKA induced transcriptional activation by CREB and blocks retinoic acid induced neuronal differentiation. (PubMed id 10442638)1, 9 Reddy U.R....Pleasure D. (Oncogene 1999)
    10. The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation. (PubMed id 15695824)1, 9 Robitaille H....Germain L. (J. Biol. Chem. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7786 HGNC: 6851 AceView: MAP3K12 Ensembl:ENSG00000139625 euGenes: HUgn7786
    ECgene: MAP3K12 Kegg: 7786 H-InvDB: MAP3K12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAP3K12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP3K12 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAP3K12 gene:
    Search GeneIP for patents involving MAP3K12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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