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Aliases for MAP3K12 Gene

Aliases for MAP3K12 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 12 2 3
  • ZPK 3 4 6
  • Dual Leucine Zipper Bearing Kinase 3 4
  • Dual Leucine Zipper Kinase DLK 2 3
  • Mixed Lineage Kinase 3 4
  • MAPK-Upstream Kinase 3 4
  • EC 4 63
  • DLK 3 4
  • MUK 3 4
  • Leucine Zipper Protein Kinase 3
  • Leucine-Zipper Protein Kinase 4
  • Protein Kinase MUK 3
  • EC 2.7.11 63
  • MEKK12 3
  • ZPKP1 3

External Ids for MAP3K12 Gene

Previous HGNC Symbols for MAP3K12 Gene

  • ZPK

Previous GeneCards Identifiers for MAP3K12 Gene

  • GC12M053870
  • GC12M053986
  • GC12M053591
  • GC12M052160
  • GC12M050914

Summaries for MAP3K12 Gene

Entrez Gene Summary for MAP3K12 Gene

  • This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]

GeneCards Summary for MAP3K12 Gene

MAP3K12 (Mitogen-Activated Protein Kinase Kinase Kinase 12) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include protein homodimerization activity and protein kinase binding. An important paralog of this gene is MAP3K9.

UniProtKB/Swiss-Prot for MAP3K12 Gene

  • May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro

Gene Wiki entry for MAP3K12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K12 Gene

Genomics for MAP3K12 Gene

Regulatory Elements for MAP3K12 Gene

Transcription factor binding sites by QIAGEN in the MAP3K12 gene promoter:

Genomic Location for MAP3K12 Gene

53,479,669 bp from pter
53,500,063 bp from pter
20,395 bases
Minus strand

Genomic View for MAP3K12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP3K12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K12 Gene

Proteins for MAP3K12 Gene

  • Protein details for MAP3K12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 12
    Protein Accession:
    Secondary Accessions:
    • B3KSS9
    • G3V1Y2
    • Q86VQ5
    • Q8WY25

    Protein attributes for MAP3K12 Gene

    859 amino acids
    Molecular mass:
    93219 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with MBIP.

    Alternative splice isoforms for MAP3K12 Gene


neXtProt entry for MAP3K12 Gene

Proteomics data for MAP3K12 Gene at MOPED

Post-translational modifications for MAP3K12 Gene

  • Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP3K12 Gene

Domains for MAP3K12 Gene

Gene Families for MAP3K12 Gene

  • MAP3K :Mitogen-activated protein kinase cascade / Kinase kinase kinases

Suggested Antigen Peptide Sequences for MAP3K12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q12852
  • Interacts with MBIP through the leucine-zipper motif
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K12: view

Function for MAP3K12 Gene

Molecular function for MAP3K12 Gene

GENATLAS Biochemistry: mitogen activated protein (MAP/ERK) kinase kinase kinase 12,expressed in brain,interacting with the GTP bound form of RAC and CDC42,regulators of JNK pathway
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro

Enzyme Numbers (IUBMB) for MAP3K12 Gene

Gene Ontology (GO) - Molecular Function for MAP3K12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 8637721
GO:0004674 protein serine/threonine kinase activity ISS --
GO:0004709 MAP kinase kinase kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 16169070
genes like me logo Genes that share ontologies with MAP3K12: view
genes like me logo Genes that share phenotypes with MAP3K12: view

Animal Models for MAP3K12 Gene

MGI Knock Outs for MAP3K12:

Animal Model Products

CRISPR Products

miRNA for MAP3K12 Gene

miRTarBase miRNAs that target MAP3K12

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP3K12

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for MAP3K12 Gene

Localization for MAP3K12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP3K12 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for MAP3K12 Gene COMPARTMENTS Subcellular localization image for MAP3K12 gene
Compartment Confidence
cytosol 4
plasma membrane 4
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MAP3K12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8663324
GO:0005829 cytosol ISS --
GO:0005886 plasma membrane ISS --
GO:0016020 membrane ISS 9353328
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with MAP3K12: view

Pathways for MAP3K12 Gene

genes like me logo Genes that share pathways with MAP3K12: view

Pathways by source for MAP3K12 Gene

1 KEGG pathway for MAP3K12 Gene
1 GeneGo (Thomson Reuters) pathway for MAP3K12 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MAP3K12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0006468 protein phosphorylation ISS --
GO:0007254 JNK cascade ISS 9353328
GO:0016572 histone phosphorylation ISS --
GO:0018105 peptidyl-serine phosphorylation ISS --
genes like me logo Genes that share ontologies with MAP3K12: view

Compounds for MAP3K12 Gene

(3) HMDB Compounds for MAP3K12 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • Magnesium

(7) Novoseek inferred chemical compound relationships for MAP3K12 Gene

Compound -log(P) Hits PubMed IDs
leucine 69.3 29
threonine 43.9 2
okadaic acid 38.4 1
serine 23.4 2
cyclic amp 20.2 5
genes like me logo Genes that share compounds with MAP3K12: view

Transcripts for MAP3K12 Gene

Unigene Clusters for MAP3K12 Gene

Mitogen-activated protein kinase kinase kinase 12:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP3K12

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MAP3K12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K12 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP6: -

Relevant External Links for MAP3K12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP3K12 Gene

mRNA expression in normal human tissues for MAP3K12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP3K12 Gene

This gene is overexpressed in Brain - Cerebellum (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MAP3K12 Gene

SOURCE GeneReport for Unigene cluster for MAP3K12 Gene Hs.713539

mRNA Expression by UniProt/SwissProt for MAP3K12 Gene

Tissue specificity: Highly expressed in brain and kidney
genes like me logo Genes that share expressions with MAP3K12: view

In Situ Assay Products

Orthologs for MAP3K12 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP3K12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAP3K12 35
  • 99.77 (n)
  • 99.77 (a)
MAP3K12 36
  • 100 (a)
(Bos Taurus)
Mammalia MAP3K12 35
  • 92.36 (n)
  • 97.21 (a)
MAP3K12 36
  • 97 (a)
(Canis familiaris)
Mammalia MAP3K12 35
  • 91.37 (n)
  • 97.53 (a)
MAP3K12 36
  • 97 (a)
(Mus musculus)
Mammalia Map3k12 35
  • 90.69 (n)
  • 96.4 (a)
Map3k12 16
Map3k12 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia MAP3K12 36
  • 78 (a)
(Rattus norvegicus)
Mammalia Map3k12 35
  • 90.17 (n)
  • 95.61 (a)
(Gallus gallus)
Aves MAP3K12 36
  • 86 (a)
(Anolis carolinensis)
Reptilia MAP3K12 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia map3k12 35
  • 67.55 (n)
  • 73.58 (a)
(Danio rerio)
Actinopterygii map3k12 35
  • 71.59 (n)
  • 78.3 (a)
MAP3K12 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta wnd 36
  • 32 (a)
CG8789 37
  • 60 (a)
(Caenorhabditis elegans)
Secernentea dlk-1 36
  • 27 (a)
Species with no ortholog for MAP3K12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP3K12 Gene

Gene Tree for MAP3K12 (if available)
Gene Tree for MAP3K12 (if available)

Paralogs for MAP3K12 Gene

Selected SIMAP similar genes for MAP3K12 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MAP3K12: view

Variants for MAP3K12 Gene

Sequence variations from dbSNP and Humsavar for MAP3K12 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs784564 -- 53,481,751(+) TACAT(A/G)CAAGC intron-variant
rs784565 -- 53,483,778(+) CATAA(C/T)AGATC intron-variant
rs1716966 -- 53,488,090(+) CACAC(C/T)CCTGG intron-variant
rs2256970 -- 53,489,300(+) ggcga(A/C)gtagc intron-variant
rs2450105 -- 53,492,061(-) agtct(A/C/G/T)actct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP3K12 Gene

Variant ID Type Subtype PubMed ID
nsv714 CNV Insertion 18451855
esv2745906 CNV Deletion 23290073
esv2289574 CNV Deletion 18987734
esv992595 CNV Deletion 20482838
esv2745908 CNV Deletion 23290073
esv1293318 CNV Deletion 17803354

Relevant External Links for MAP3K12 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K12 Gene

Disorders for MAP3K12 Gene

(1) University of Copenhagen DISEASES for MAP3K12 Gene

(1) Novoseek inferred disease relationships for MAP3K12 Gene

Disease -log(P) Hits PubMed IDs
teratocarcinoma 64.5 2

Relevant External Links for MAP3K12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MAP3K12: view

No data available for UniProtKB/Swiss-Prot for MAP3K12 Gene

Publications for MAP3K12 Gene

  1. Cloning of a novel putative protein kinase having a leucine zipper domain from human brain. (PMID: 8037767) Reddy U.R. … Pleasure D. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 23
  2. SP3 acts as a positive regulator on the core promoter of human ZPK gene. (PMID: 14697235) Itoh A. … Itoh T. (Biochem. Biophys. Res. Commun. 2004) 3 4 23
  3. ZPK inhibits PKA induced transcriptional activation by CREB and blocks retinoic acid induced neuronal differentiation. (PMID: 10442638) Reddy U.R. … Pleasure D. (Oncogene 1999) 3 23
  4. MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/Dual leucine zipper-bearing kinase/leucine zipper protein kinase. (PMID: 10801814) Fukuyama K. … Ohno S. (J. Biol. Chem. 2000) 3 4
  5. The small heat-shock protein Hsp27 undergoes ERK-dependent phosphorylation and redistribution to the cytoskeleton in response to dual leucine zipper-bearing kinase expression. (PMID: 19675578) Robitaille H. … Germain L. (J. Invest. Dermatol. 2010) 3 23

Products for MAP3K12 Gene

Sources for MAP3K12 Gene

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