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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP3K12 Gene

protein-coding   GIFtS: 64
GCID: GC12M053870

mitogen-activated protein kinase kinase kinase 12


(Previous symbol: ZPK)
 Explore 10 diseases affiliated with
MAP3K12 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAP3K12    

Aliases
for MAP3K12 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 121 2     MAPK-Upstream Kinase2 3
ZPK1 2 3 5     EC 2.7.11.253 8
DLK1 2 3     Dual Leucine Zipper Kinase DLK2
MUK1 2 3     Leucine Zipper Protein Kinase2
MEKK121 2     Protein Kinase MUK2
ZPKP11 2     Leucine-Zipper Protein Kinase3
Dual Leucine Zipper Bearing Kinase2 3     EC 2.7.118
Mixed Lineage Kinase2 3     

External Ids:    HGNC: 68511   Entrez Gene: 77862   Ensembl: ENSG000001396257   OMIM: 6004475   UniProtKB: Q128523   

Export aliases for MAP3K12 gene to outside databases

Previous GC identifers: GC12M053986 GC12M053591 GC12M052160 GC12M050914


Summaries
for MAP3K12 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAP3K12:
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain
and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was
shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper
containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a
regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants
encoding different proteins have been described.(provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: M3K12_HUMAN, Q12852
Function: May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein
in vitro

Gene Wiki entry for MAP3K12


Genomic Views
for MAP3K12 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP3K12 gene promoter:
         Sp1   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAP3K12 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP3K12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13

MAP3K12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K12 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M053870:  view genomic region     (about GC identifiers)

Start:
 53,874,274 bp from pter      End:
 53,893,847 bp from pter
Size:
 19,574 bases      Orientation:
 minus strand

Proteins
for MAP3K12 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: M3K12_HUMAN, Q12852 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 12  
Size: 859 amino acids; 93219 Da
Cofactor: Magnesium
Subunit: Interacts with MBIP
Subcellular location: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity)
Secondary accessions: B3KSS9 G3V1Y2 Q86VQ5 Q8WY25
Alternative splicing: 2 isoforms:  Q12852-1   Q12852-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP3K12: NX_Q12852

Post-translational modifications:

  • Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when
    • membrane-associated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q12852

    • 4/19 DME Specific Peptides for MAP3K12 (Q12852) (see all 19)
     IGKAYST  STFSSEN  WMAPEVI  LWELLTGE 

    MAP3K12 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001180440.1  NP_006292.3  

    ENSEMBL proteins: 
     ENSP00000267079   ENSP00000449038   ENSP00000448689   ENSP00000447889   ENSP00000454355  

    Human Recombinant Protein Products: 
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    Uscn Proteins for MAP3K12

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm TAS8663324
    GO:0005829cytosol ISS--
    GO:0005886plasma membrane ISS--
    GO:0016020membrane ISS9353328


    MAP3K12 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MAP3K12

    Protein Domains /
    Families
    for MAP3K12 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAP3K12 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR017419 MAP3K12_MAP3K13

    Graphical View of Domain Structure for InterPro Entry Q12852

    ProtoNet protein and cluster: Q12852

    UniProtKB/Swiss-Prot: M3K12_HUMAN, Q12852
    Domain: Interacts with MBIP through the leucine-zipper motif
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for MAP3K12 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: M3K12_HUMAN, Q12852
    Function: May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein
    in vitro
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for MAP3K12:
    mitogen activated protein (MAP/ERK) kinase kinase kinase 12,expressed in brain,interacting with the GTP bound form of
    RAC and CDC42,regulators of JNK pathway

    Enzyme Numbers (IUBMB): EC 2.7.11.251 2 EC 2.7.112

    miRNA
    Products:            		miRTarBase miRNAs that target MAP3K12:
    hsa-mir-17 (MIRT003013), hsa-mir-20a (MIRT003010)

    OriGene 3'-UTR Clone: MAP3K12
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP3K12
    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP3K12 (see all 55):
    hsa-miR-4317 hsa-miR-513a-5p hsa-miR-106a hsa-miR-301a hsa-miR-30d hsa-miR-519a hsa-miR-374a* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: MAP3K12 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP3K12 (see all 7)
    OriGene shRNA RFP: MAP3K12
    OriGene siRNA: MAP3K12
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP3K12

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAP3K12

    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K12

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004672protein kinase activity TAS8663324
    GO:0004674protein serine/threonine kinase activity ISS9353328
    GO:0004709MAP kinase kinase kinase activity IEA--
    GO:0005515protein binding IPI16169070


    MAP3K12 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for MAP3K12:
     Decreased substrate adherent c  Increased S DNA content  Increased cell death in DLD-1   Increased cell size 
     Increased number of mitotic ce 

    Animal Models:
         Mouse knock-outs for MAP3K12: Map3k12tm1.1Lewc Map3k12tm1Shir Map3K12tm1.2Adia
         4 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Map3k12):
     cellular  homeostasis/metabolism  mortality/aging  nervous system 

    MAP3K12 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAP3K12 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signal transduction_JNK pathway
    		Signal transduction_JNK pathway1.00
    		Signal transduction JNK pathway0.98
    2MAPK signaling pathway
    		MAPK signaling pathway1.00
    		MAPK signaling pathway0.50
    3NFAT and Cardiac Hypertrophy
    		NFAT and Cardiac Hypertrophy1.00
    4Insulin Signaling
    		Insulin Signaling1.00
    5Regulation of p38-alpha and p38-beta
    		Regulation of p38-alpha and p38-beta1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for MAP3K12
        Signal transduction JNK pathway

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP3K12
        PACAP Signaling
    TNFR2 Pathway
    NFAT and Cardiac Hypertrophy
    WNT Signaling
    MAPK Family Pathway

    1 GeneGo (Thomson Reuters) Pathway for MAP3K12
        Signal transduction JNK pathway

    4 BioSystems Pathways for MAP3K12 
        MAPK signaling pathway
    MAPK Cascade
    Insulin Signaling
    Regulation of p38-alpha and p38-beta


    1         Kegg Pathway  (Kegg details for MAP3K12):
        MAPK signaling pathway


    MAP3K12 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP3K12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/26 Interacting proteins for MAP3K12 (Q128521, 2, 3 ENSP000002670794) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FRA10AC1Q70Z531, 2, 3EBI-710223,EBI-710176 MINT-64738 I2D: score=3 
    FTLP027922, 3MINT-63358 I2D: score=4 
    RGS1Q081162, 3MINT-64059 I2D: score=4 
    TSC22D1Q157142, 3MINT-64576 I2D: score=4 
    MAPK6Q166592, 3MINT-8261362 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ISS--
    GO:0007243intracellular protein kinase cascade TAS7983011
    GO:0007254JNK cascade ISS9353328
    GO:0016572histone phosphorylation ISS--
    GO:0018105peptidyl-serine phosphorylation ISS--


    MAP3K12 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAP3K12 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP3K12 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MAP3K12

    3 HMDB Compounds for MAP3K12    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    7 Novoseek chemical compound relationships for MAP3K12 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 69.3 45 11069624 (9), 14739943 (2), 19675578 (2), 8037767 (2) (see all 14)
    threonine 43.9 3 8037767 (1), 11069624 (1)
    okadaic acid 38.4 1 8663324 (1)
    serine 23.4 3 8037767 (1), 11069624 (1)
    cyclic amp 20.2 6 16369771 (4), 10442638 (1)
    retinoic acid 15.4 2 10442638 (2)
    calcium 0 1 8663324 (1)

    Search CenterWatch for drugs/clinical trials and news about MAP3K12 / M3K12 

    Transcripts
    for MAP3K12 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAP3K12 gene (2 alternative transcripts): 
    NM_001193511.1  NM_006301.3  

    Unigene Cluster for MAP3K12:

    Mitogen-activated protein kinase kinase kinase 12
    Hs.713539  [show with all ESTs]
    Unigene Representative Sequence: AB209453
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000547020 ENST00000267079(uc001sdm.2 uc001sdn.2) ENST00000547488
    ENST00000551511 ENST00000547035 ENST00000552365 ENST00000548690 ENST00000547151
    ENST00000551895 ENST00000547803 ENST00000548565

    miRNA
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    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP3K12 (see all 55):
    hsa-miR-4317 hsa-miR-513a-5p hsa-miR-106a hsa-miR-301a hsa-miR-30d hsa-miR-519a hsa-miR-374a* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: MAP3K12 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB209453.1 AK094109.1 AK094195.1 AK314530.1 BC037585.1 BC050050.1 U07358.1 

    12 DOTS entries:

    DT.100643847  DT.91776664  DT.95327182  DT.121179533  DT.121179538  DT.121179599  DT.95327295  DT.99938668 
    DT.92020435  DT.91705078  DT.121179531  DT.121179640 

    24/112 AceView cDNA sequences (see all 112):

    AW298368 D31090 BM467946 BU743249 CA388686 AA258669 CB164332 BQ028422 
    BM460977 AW470380 AW444664 BU623582 CA411906 AA258279 AA383035 BX095794 
    AW295114 BF438012 BX435939 AI217632 AA573387 BM930057 BF447526 BE222201 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K12 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16
    SP1:              -           -                 -                 -                 -                                                               
    SP2:                                            -                 -                 -                                                               
    SP3:              -                             -                 -                 -                                                               
    SP4:                          -     -           -                                                                                                   
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for MAP3K12

    Expression
    for MAP3K12 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP3K12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGATGGCTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MAP3K12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP3K12

    SOURCE GeneReport for Unigene cluster: Hs.713539

    UniProtKB/Swiss-Prot: M3K12_HUMAN, Q12852
    Tissue specificity: Highly expressed in brain and kidney

        SABiosciences Expression via Pathway-Focused PCR Array including MAP3K12: 
              Cell Lineage Identification in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K12

    Orthologs
    for MAP3K12 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAP3K12 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia MAP3K126
    		 --
    		 76(a)
    		 1 ↔ 1
    		 2(73309341-73348730)
    zebrafish
    (Danio rerio)    		 Actinopterygii map3k121 mitogen-activated protein kinase kinase kinase 12 67.56(n)
    71.12(a)    		   404626  NM_207094.1  NP_996977.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG87893 protein amino acid phosphorylation protein
    kinase    		 60(a)   76B9   --
    worm
    (Caenorhabditis elegans)    		 Secernentea dlk-16
    zak-16
    		 Mitogen-activated protein kinase kinase kinase dlk...
    mammalian ZAK kinase homolog family member (zak-1)...
    		 25(a)
    16(a)
    		 1 ↔ many
    possible ortholog
    		 I(12565789-12572791)
    III(6853054-6856750)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G066306
    AtCTR16
    (see all 12)    		 serine/threonine-protein kinase CTR1
    (see all 12)    		 14(a)
    13(a)
    (see all 12)    		 possible ortholog
    possible ortholog
    (see all 12)    		 3(2070388-2073800)
    5(974498-979849)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 9)    		 CTR1-like protein kinase, putative, expressed
    protein kinase family protein, putative, expressed...
    (see all 9)    		 9(a)
    14(a)
    (see all 9)    		 possible ortholog
    possible ortholog
    (see all 9)    		 9(22598493-22607901)
    12(23027641-23034893)


    ENSEMBL Gene Tree for MAP3K12 (if available)
    TreeFam Gene Tree for MAP3K12 (if available) 

    Paralogs
    for MAP3K12 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP3K12 gene
    MAP3K112  KIAA18042  RAF12  KSR22  KSR12  MOS2  BRAF2  MAP3K102  
    MAP3K92  ARAF2  MAP3K72  MAP3K7CL2  TNNI3K2  ZAK2  MAP3K132  ILK2  
    10 SIMAP similar genes for MAP3K12 using alignment to 3 protein entries:     M3K12_HUMAN (see all proteins):
    MAP3K13    MLTK    pk    MAP3K9    MAP3K10    MAP3K11
    EPHA2    MLK4    BMX    CDK4

    MAP3K12 for paralogs           About GeneDecksing



    Genomic Variants
    for MAP3K12 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/273 NCBI SNPs in MAP3K12 are shown (see all 273)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs7845641,2
    		C,F,H,--53875535(+) TACATA/GCAAGC 2 -- int122Minor allele frequency- G:0.16NS EA NA WA CSA 1744
    rs1421266481,2
    		C,--53875741(+) GAAGTT/GCCTGG 4 /E /A mis11Minor allele frequency- G:0.00NA 4552
    rs2013325531,2
    		--53875769(+) GCTGGA/GTTCAG 4 P S mis10--------
    rs2005044181,2
    		--53875883(+) GCCAAC/TTTCAG 4 I V mis10--------
    rs1401314301,2
    		C,--53875902(+) CTGGGG/CGAAGG 4 /S syn11Minor allele frequency- C:0.00NA 4552
    rs1498765911,2
    		C--53875972(+) ACTGGC/TGCATG 4 H R mis11Minor allele frequency- T:0.00NA 4552
    rs1387223741,2
    		C,--53876055(+) AATGCC/TATTAA 2 -- int10--------
    rs1493424181,2
    		C,--53876179(+) GGGGGC/GTCTGA 2 -- int10--------
    rs1447395441,2
    		C,--53876183(+) GGTCTA/GATTAG 2 -- int10--------
    rs170997391,2
    		C,F,H,--53876289(+) TAGACT/CTGGAC 2 -- int113Minor allele frequency- C:0.06NA NS EA EU 1797

    HapMap Linkage Disequilibrium report for MAP3K12 (53874274 - 53893847 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MAP3K12: --

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    Disorders / Diseases
    for MAP3K12 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAP3K12 for disorders           About GeneDecksing

    OMIM gene information: 600447    OMIM disorders: --

    10 diseases for MAP3K12:    About MalaCards
    ureteral obstruction    neuronitis    teratocarcinoma    astigmatism
    keratitis    parkinson's disease    ischemia    glioblastoma
    thyroiditis    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for MAP3K12:
    Parkinson's disease

    1 Novoseek disease relationship for MAP3K12 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    teratocarcinoma 64.5 3 10442638 (1), 16369771 (1)

    Human Genome Epidemiology (HuGE) Navigator: MAP3K12 (2 documents)

    Export disorders for MAP3K12 gene to outside databases

    Publications
    for MAP3K12 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP3K12 gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with MAP3K12)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel putative protein kinase having a leucine zipper domain from human brain. (PubMed id 8037767)1, 2, 3, 9 Reddy U.R. and Pleasure D. (1994)
    2. SP3 acts as a positive regulator on the core promoter of human ZPK gene. (PubMed id 14697235)1, 2, 9 Itoh A.... Itoh T. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/Dual leucine zipper-bearing kinase/leucine zipper protein kinase. (PubMed id 10801814)1, 2 Fukuyama K.... Ohno S. (2000)
    6. Characterization of dual leucine zipper-bearing kinase, a mixed lineage kinase present in synaptic terminals whose phosphorylation state is regulated by membrane depolarization via calcineurin. (PubMed id 8663324)1, 9 Mata M....Holzman L.B. (1996)
    7. ZPK inhibits PKA induced transcriptional activation by CREB and blocks retinoic acid induced neuronal differentiation. (PubMed id 10442638)1, 9 Reddy U.R....Pleasure D. (1999)
    8. The mitogen-activated protein kinase kinase kinase dual leucine zipper-bearing kinase (DLK) acts as a key regulator of keratinocyte terminal differentiation. (PubMed id 15695824)1, 9 Robitaille H....Germain L. (2005)
    9. The small heat-shock protein Hsp27 undergoes ERK-depe ndent phosphorylation and redistribution to the cytoskeleton in response to dua l leucine zipper-bearing kinase expression. (PubMed id 19675578)1, 9 Robitaille H....Germain L. (2010)
    10. The mixed lineage kinase DLK is oligomerized by tissue transglutaminase during apoptosis. (PubMed id 10922377)1, 9 Hebert S.S....Blouin R. (2000)

    External Searches for MAP3K12 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing MAP3K12 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7786 HGNC: 6851 AceView: MAP3K12 Ensembl:ENSG00000139625 euGenes: HUgn7786
    ECgene: MAP3K12 Kegg: 7786 H-InvDB: MAP3K12

    Other Databases showing MAP3K12 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAP3K12 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP3K12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP3K12 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MAP3K12 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAP3K12 gene:
    Search GeneIP for patents involving MAP3K12

    GeneCards and IP:
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