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MAP3K11 Gene

protein-coding   GIFtS: 69
GCID: GC11M065365

Mitogen-Activated Protein Kinase Kinase Kinase 11


(Previous symbols: MLK3, PTK1)
  Search for MAP3K11
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 111 2     EC 2.7.11.253 8
MLK31 2 3 5     MEKK112
PTK11 2 3 5     MLK-32
SPRK2 3 5     Protein-Tyrosine Kinase PTK12
Mixed Lineage Kinase 32 3     SH3 Domain-Containing Proline-Rich Kinase2
Src-Homology 3 Domain-Containing Proline-Rich Kinase2 3     EC 2.7.118

External Ids:    HGNC: 68501   Entrez Gene: 42962   Ensembl: ENSG000001733277   OMIM: 6000505   UniProtKB: Q165843   

Export aliases for MAP3K11 gene to outside databases

Previous GC identifers: GC11M067881 GC11M067046 GC11M065615 GC11M065140 GC11M065121 GC11M061692


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP3K11 Gene:
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3
domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as
a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB
kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho
family GTPases and CDC42. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAP3K11 Gene:
MAP3K11 (mitogen-activated protein kinase kinase kinase 11) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and protein homodimerization activity. An important paralog of this gene is FPGT-TNNI3K.

UniProtKB/Swiss-Prot: M3K11_HUMAN, Q16584
Function: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen
and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of
MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does
not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle

Gene Wiki entry for MAP3K11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP3K11 gene promoter:
         NF-1   NF-1/L   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MAP3K11 promoter sequence
   Search Chromatin IP Primers for MAP3K11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP3K11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1-q13.3   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1-q13.3

MAP3K11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K11 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M065365:  view genomic region     (about GC identifiers)

Start:
65,365,226 bp from pter      End:
65,382,853 bp from pter
Size:
17,628 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: M3K11_HUMAN, Q16584 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 11  
Size: 847 amino acids; 92688 Da
Cofactor: Magnesium (By similarity)
Subunit: Homodimer; undergoes dimerization during activation. Interacts with MAP2K4/MKK4. Interacts with
MAP2K7/MKK7 (By similarity)
Sequence caution: Sequence=BAD92892.1; Type=Erroneous initiation;
Secondary accessions: Q53H00 Q59F06 Q6P2G4

Explore the universe of human proteins at neXtProt for MAP3K11: NX_Q16584

Explore proteomics data for MAP3K11 at MOPED

Post-translational modifications: 

  • Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.
    Thr-277 is likely to be the main autophosphorylation site. Phosphorylation of Ser-555 and Ser-556 is induced by
    CDC421
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAP3K11 (Q16584) (see all 10)
     SGDEGWW  WMAPEVI  VIHRDLK  EQLRRRE 


    See MAP3K11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002410.1  
    ENSEMBL proteins: 
     ENSP00000309597   ENSP00000432068   ENSP00000433886   ENSP00000431506   ENSP00000435970  
     ENSP00000435237  

    MAP3K11 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for MAP3K11
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MAP3K11
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    Novus Biologicals MAP3K11 Proteins
    Novus Biologicals MAP3K11 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAP3K11

     
    Search eBioscience for Proteins for MAP3K11 

    MAP3K11 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Cell Signaling Technology (CST) Antibodies for MAP3K11  (MLK3)
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    Abcam antibodies for MAP3K11
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    MAP3K11 Assay Products:

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    Cloud-Clone Corp. ELISAs for MAP3K11
    Cloud-Clone Corp. CLIAs for MAP3K11
    Search eBioscience for ELISAs for MAP3K11 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAP3K: Mitogen-activated protein kinase cascade / Kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase 11
    MLK subfamily

    Selected InterPro protein domains (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR016231 MAPKKK9/10/11
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q16584

    ProtoNet protein and cluster: Q16584

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: M3K11_HUMAN, Q16584
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with MAP3K11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M3K11_HUMAN, Q16584
    Function: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen
    and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of
    MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does
    not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Homodimerization via the leucine zipper domains is required for autophosphorylation and
    subsequent activation

         Genatlas biochemistry entry for MAP3K11:
    mitogen activated protein (MAP/ERK) kinase kinase kinase 11,interacting specifically with the GTP bound form of
    RAC and CDC42,regulators of JNK pathway

         Enzyme Numbers (IUBMB): EC 2.7.11.251 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS10799501
    GO:0004674protein serine/threonine kinase activity IDA8195146
    GO:0004706JUN kinase kinase kinase activity ISS--
    GO:0004709MAP kinase kinase kinase activity ----
    GO:0004713protein tyrosine kinase activity IEA--
         
    Find genes that share ontologies with MAP3K11           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for MAP3K11:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased cell death in HCC-19  Increased circadian period len 
     Increased viability after born  Weaker migration 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Map3k11):
     cellular  craniofacial  homeostasis/metabolism  immune system  integument 
     mortality/aging 

    Find genes that share phenotypes with MAP3K11           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Map3k11tm1Rjd for MAP3K11

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAP3K11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAP3K11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP3K11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP3K11

    miRNA
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    miRTarBase miRNAs that target MAP3K11:
    hsa-mir-199a-5p (MIRT005873)

    Block miRNA regulation of human, mouse, rat MAP3K11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP3K11 (see all 54):
    hsa-miR-302d hsa-miR-520e hsa-miR-3938 hsa-miR-106a hsa-miR-372 hsa-miR-93 hsa-miR-302b hsa-miR-4326
    SwitchGear 3'UTR luciferase reporter plasmidMAP3K11 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAP3K11
    Predesigned siRNA for gene silencing in human, mouse, rat MAP3K11

    Gene Editing
    Products:
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    Clone
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    OriGene ORF clones in mouse, rat for MAP3K11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAP3K11 (NM_002419)
    Sino Biological Human cDNA Clone for MAP3K11
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP3K11
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    Addgene plasmids for MAP3K11 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MAP3K11 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    M3K11_HUMAN, Q16584: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Location is cell
    cycle dependent
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome IDA12529434
    GO:0005874microtubule IDA12529434

    Find genes that share ontologies with MAP3K11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP3K11 About   (see all 24)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2ERK Signaling
    Rho Family GTPases0.61
    MAPK Signaling0.58
    3TGF-Beta Pathway
    MAPK Family Pathway0.60
    JNK Pathway0.51
    4G protein signaling RAC1 in cellular process
    G protein signaling RAC1 in cellular process0.37
    Cytoskeleton remodeling CDC42 in cellular processes0.37
    5CDC42 signaling events
    CDC42 signaling events0.34
    RAC1 signaling pathway0.34


    Find genes that share SuperPaths with MAP3K11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAP3K11 (see all 13)
        MAPK Signaling
    STAT3 Pathway
    CDC42 Pathway
    JNK Pathway
    TNFR2 Pathway

    1 Cell Signaling Technology (CST) Pathway for MAP3K11
        MAP Kinase Signaling

    Selected GeneGo (Thomson Reuters) Pathways for MAP3K11 (see all 7)
        Development FGF-family signaling
    Signal transduction JNK pathway
    G-protein signaling RAC1 in cellular process
    Cytoskeleton remodeling CDC42 in cellular processes
    Transcription CREB pathway

    Selected BioSystems Pathways for MAP3K11 (see all 6)
        MAPK signaling pathway
    Insulin Signaling
    CDC42 signaling events
    Reelin signaling pathway
    IFN-gamma pathway


    1 PharmGKB Pathway for MAP3K11
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for MAP3K11):
        MAPK signaling pathway
    Non-alcoholic fatty liver disease (NAFLD)

        Pathway & Disease-focused RT2 Profiler PCR Array including MAP3K11: 
              Cytoskeleton Regulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAP3K11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAP3K11 (Q165841, 2, 3 ENSP000003095974) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC42P609531, 3, ENSP000003144584EBI-49961,EBI-81752 I2D: score=3 STRING: ENSP00000314458
    MAP4K1Q929182, 3, ENSP000003800664MINT-7213051 I2D: score=5 STRING: ENSP00000380066
    CHUKO151113, ENSP000003594244I2D: score=4 STRING: ENSP00000359424
    COPS5Q929053, ENSP000003505124I2D: score=3 STRING: ENSP00000350512
    KIF3AQ9Y4963, ENSP000003680204I2D: score=3 STRING: ENSP00000368020
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000080mitotic G1 phase IMP15258589
    GO:0000187activation of MAPK activity IMP15258589
    GO:0006468protein phosphorylation IDA11053428
    GO:0007017microtubule-based process IMP12529434
    GO:0007254JNK cascade TAS10799501

    Find genes that share ontologies with MAP3K11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAP3K11 (M3K11)

    3 HMDB Compounds for MAP3K11    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Selected Novoseek inferred chemical compound relationships for MAP3K11 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kt 7515 91.8 5 12388555 (2), 12354290 (1), 16785569 (1)
    threonine 57.2 12 9003778 (1), 10799501 (1), 11590155 (1), 11713255 (1) (see all 7)
    leucine 51.6 12 9829970 (3), 16253996 (1), 18199767 (1), 15069087 (1) (see all 8)
    serine 46.9 12 9003778 (1), 10799501 (1), 11590155 (1), 11713255 (1) (see all 7)
    phosphatidylinositol 32.1 1 14504284 (1)
    proline 30.2 2 11590155 (1), 8195146 (1)
    isoleucine 25.8 2 9829970 (2)
    ceramide 21 14 12504027 (4)
    tyrosine 20.8 2 15467451 (1), 9829970 (1)
    gtp 8.19 1 7493928 (1)



    Find genes that share compounds with MAP3K11           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAP3K11 gene: 
    NM_002419.3  

    Unigene Cluster for MAP3K11:

    Mitogen-activated protein kinase kinase kinase 11
    Hs.502872  [show with all ESTs]
    Unigene Representative Sequence: BC064543
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309100(uc001oew.3) ENST00000532507(uc001oev.3) ENST00000530153(uc001oex.1 uc010rol.2)
    ENST00000524848 ENST00000534432 ENST00000526647 ENST00000524856 ENST00000533032
    ENST00000530949 ENST00000526293 ENST00000529839 ENST00000534110 ENST00000527304

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    Selected qRT-PCR Assays for microRNAs that regulate MAP3K11 (see all 54):
    hsa-miR-302d hsa-miR-520e hsa-miR-3938 hsa-miR-106a hsa-miR-372 hsa-miR-93 hsa-miR-302b hsa-miR-4326
    SwitchGear 3'UTR luciferase reporter plasmidMAP3K11 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: MAP3K11 (NM_002419)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP3K11
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    Addgene plasmids for MAP3K11 
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      QuantiTect SYBR Green Assays in human, mouse, rat MAP3K11
      QuantiFast Probe-based Assays in human, mouse, rat MAP3K11

    Additional mRNA sequence: 

    AK090614.1 AK222781.1 AK299609.1 AK310986.1 AK315557.1 AK316032.1 BC011263.2 BC064543.1 
    L32976.1 U07747.1 

    14 DOTS entries:

    DT.411131  DT.97809626  DT.100656865  DT.100752452  DT.100752455  DT.100752453  DT.120745956  DT.120745959 
    DT.92431194  DT.100752451  DT.100752459  DT.95108831  DT.120745961  DT.75123986 

    Selected AceView cDNA sequences (see all 160):

    BQ227232 AW600310 BU628843 CR608023 BQ941183 BX118590 BQ674554 BM552088 
    BQ225230 L32976 BM967126 BC011263 BM925687 AU119385 BM915402 CA393665 
    BC064543 BF984547 U07747 BQ436921 NM_002419 CD614777 BU168688 BU661670 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K11 (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ·
    SP1:                                                                                                        -                 -           -                     
    SP2:                          -                                               -     -     -                 -                                                   
    SP3:                                                                          -     -     -                 -                 -                                 
    SP4:                                                                          -     -     -                 -                                                   
    SP5:                                                                          -     -     -                 -                 -           -     -               

    ExUns: 12c ^ 13 ^ 14
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for MAP3K11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAP3K11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCTCCTGC
    MAP3K11 Expression
    About this image

    MAP3K11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP3K11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.502872

    UniProtKB/Swiss-Prot: M3K11_HUMAN, Q16584
    Tissue specificity: Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver,
    heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain

        Pathway & Disease-focused RT2 Profiler PCR Array including MAP3K11: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAP3K11 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map3k111 , 5 mitogen-activated protein kinase kinase kinase 111, 5 86.17(n)1
    94.68(a)1
      19 (4.34 cM)5
    264031  NM_022012.31  NP_071295.21 
     56891315 
    lizard
    (Anolis carolinensis)
    Reptilia MAP3K116
    mitogen-activated protein kinase kinase kinase 11
    75(a)
    1 ↔ 1
    GL343360.1(270345-279745)
    zebrafish
    (Danio rerio)
    Actinopterygii MAP3K116
    mitogen-activated protein kinase kinase kinase 11
    69(a)
    1 ↔ 1
    7(747449-751076) ENSDARG00000091521
    fruit fly
    (Drosophila melanogaster)
    Insecta slpr3 JNK cascade protein kinase 49(a)   7D17   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HT11 HT1 46.32(n)
    35.79(a)
      842538  NM_104920.2  NP_176430.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g06366001 Os06g0636600 50.63(n)
    35.71(a)
      4341603  NM_001064679.1  NP_001058144.1 


    ENSEMBL Gene Tree for MAP3K11 (if available)
    TreeFam Gene Tree for MAP3K11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP3K11 gene
    FPGT-TNNI3K2  ARAF2  MAP3K122  KIAA18042  RAF12  KSR22  MAP3K72  TNNI3K2  
    KSR12  ZAK2  MOS2  MAP3K132  BRAF2  ILK2  MAP3K92  MAP3K102  
    Selected SIMAP similar genes for MAP3K11 using alignment to 6 protein entries:     M3K11_HUMAN (see all proteins) (see all similar genes):
    MAP3K10    MAP3K13    PKN2    MARK4    GRK5    MAP3K9
    MLK4    RPS6KA1    BRAF    ULK1    CAMKK2    MAP3K12
    PRKACA    SH3GL2    BLK    LRRK1    AKT2    FPGT-TNNI3K

    Find genes that share paralogs with MAP3K11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP3K11 (see all 367)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1468314771,2
    --65365473(+) CACCCC/GAGCAG 1 -- ut310--------
    rs1997016351,2
    --65365643(+) CCAAA-/GGGGGG 1 -- ut310--------
    rs1922849591,2
    --65365662(+) CCTGGA/GGAAAC 1 -- ut310--------
    rs2000983301,2
    C--65365939(-) CCTTCC/TCCCCT 2 S syn10--------
    rs79461151,2
    C,F,A,H--65366192(+) CCCATG/CTGCAC 1 -- int111Minor allele frequency- C:0.20NS EA NA CSA WA 778
    rs79326161,2
    C,F,A,H--65366240(+) CTCCGT/CGGTGC 1 -- int119Minor allele frequency- C:0.17NS EA NA CSA WA 2342
    rs1838968561,2
    --65366391(+) CATCCA/GGGAGC 1 -- int10--------
    rs1433836151,2
    --65366490(+) TGCTAC/TGATTA 1 -- int10--------
    rs1881125621,2
    --65366491(+) GCTACA/GATTAT 1 -- int10--------
    rs112272351,2
    C,F--65366495(+) CGATTA/TTGATT 1 -- int16Minor allele frequency- T:0.21NA WA EA 364

    HapMap Linkage Disequilibrium report for MAP3K11 (65365226 - 65382853 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAP3K11 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897723CNV Loss21882294
    dgv1175n71CNV Loss21882294
    nsv897739CNV Loss21882294
    dgv1180n71CNV Loss21882294
    nsv897736CNV Loss21882294
    nsv897730CNV Loss21882294
    dgv1176n71CNV Loss21882294
    dgv1181n71CNV Loss21882294
    dgv1179n71CNV Loss21882294
    nsv897718CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600050    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for MAP3K11:
    Brain ischemia

    Find genes that share disorders with MAP3K11           About GenesLikeMe

    7 Novoseek inferred disease relationships for MAP3K11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ischemic brain injury 61.6 1 17348686 (1)
    cerebral ischemia 31 4 17348686 (1), 16831194 (1), 20219637 (1)
    necrosis 12.8 8 10713178 (2), 19918265 (1), 19586614 (1), 15001580 (1) (see all 5)
    ischemia 0 1 17348686 (1)
    neurodegenerative diseases 0 1 11438570 (1)
    dementia 0 1 12354290 (1)
    tumors 0 11 10713178 (2), 15467451 (1), 19918265 (1), 15001580 (1) (see all 7)

    Human Genome Epidemiology (HuGE) Navigator: MAP3K11 (1 document)

    Export disorders for MAP3K11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP3K11 gene, integrated from 10 sources (see all 125):
    (articles sorted by number of sources associating them with MAP3K11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain. (PubMed id 8183572)1, 2, 3, 9 Ing Y.L.... Lassam N.J. (Oncogene 1994)
    2. Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK- 3. (PubMed id 9829970)1, 2, 9 Leung I.W.L. and Lassam N.J. (J. Biol. Chem. 1998)
    3. A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization. (PubMed id 12529434)1, 2, 9 Swenson K.I.... Means A.R. (Mol. Biol. Cell 2003)
    4. Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping. (PubMed id 11969422)1, 2, 9 Vacratsis P.O.... Gallo K.A. (Biochemistry 2002)
    5. MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation. (PubMed id 15258589)1, 2, 9 Chadee D.N. and Kyriakis J.M. (Nat. Cell Biol. 2004)
    6. Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity. (PubMed id 8195146)1, 2, 9 Gallo K.A.... Godowski P.J. (J. Biol. Chem. 1994)
    7. The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation. (PubMed id 11053428)1, 2, 9 Leung I.W.L. and Lassam N.J. (J. Biol. Chem. 2001)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13. (PubMed id 9267807)1, 3 Smith C.M....Gerhard D.S. (Genome Res. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4296 HGNC: 6850 AceView: MAP3K11 Ensembl:ENSG00000173327 euGenes: HUgn4296
    ECgene: MAP3K11 Kegg: 4296 H-InvDB: MAP3K11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAP3K11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP3K11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAP3K11 gene:
    Search GeneIP for patents involving MAP3K11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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