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Aliases for MAP3K11 Gene

Aliases for MAP3K11 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 11 2 3 5
  • Src-Homology 3 Domain-Containing Proline-Rich Kinase 3 4
  • Mixed Lineage Kinase 3 3 4
  • EC 2.7.11.25 4 61
  • MLK3 3 4
  • PTK1 3 4
  • SPRK 3 4
  • SH3 Domain-Containing Proline-Rich Kinase 3
  • Protein-Tyrosine Kinase PTK1 3
  • EC 2.7.11 61
  • MEKK11 3
  • MLK-3 3

External Ids for MAP3K11 Gene

Previous HGNC Symbols for MAP3K11 Gene

  • MLK3
  • PTK1

Previous GeneCards Identifiers for MAP3K11 Gene

  • GC11M067881
  • GC11M067046
  • GC11M065140
  • GC11M065121
  • GC11M065365
  • GC11M061692

Summaries for MAP3K11 Gene

Entrez Gene Summary for MAP3K11 Gene

  • The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP3K11 Gene

MAP3K11 (Mitogen-Activated Protein Kinase Kinase Kinase 11) is a Protein Coding gene. Among its related pathways are RET signaling and Development Ligand-independent activation of ESR1 and ESR2. GO annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is MAP3K9.

UniProtKB/Swiss-Prot for MAP3K11 Gene

  • Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.

Gene Wiki entry for MAP3K11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K11 Gene

Genomics for MAP3K11 Gene

Regulatory Elements for MAP3K11 Gene

Enhancers for MAP3K11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F065650 1.9 FANTOM5 Ensembl ENCODE 22.5 -38.0 -37981 6.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 LOC105369352 RNASEH2C ZFPL1 KAT5 RBM14 MRPL11 LOC105369353 EIF1AD MUS81 MAP3K11
GH11F065609 1.5 FANTOM5 ENCODE 25.4 +1.4 1384 8.5 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MAP3K11 MRPL11 SIPA1 RNASEH2C CD248 CTSF NEAT1 LOC105369352 FAU EIF1AD
GH11F065583 1.3 Ensembl ENCODE 19 +27.2 27207 9.3 HDGF PKNOX1 ARNT MLX ARID4B SIN3A YY1 SLC30A9 ZNF143 SP3 MAP3K11 LTBP3 PCNX3 CTSW EHBP1L1 NEAT1 SIPA1 RELA ENSG00000250105 PACS1
GH11F065636 1.3 FANTOM5 ENCODE 17.9 -25.3 -25301 8.2 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A YBX1 GLIS2 ZNF207 SIPA1 KCNK7 RNASEH2C MAP3K11 EHBP1L1 TIGD3 FAM89B SSSCA1 CFL1 SNX32
GH11F065769 1 Ensembl ENCODE 22.2 -154.6 -154555 0.7 CTCF CEBPG ZIC2 RAD21 GATA3 GLIS2 POLR2A GATA2 SMC3 TRIM24 MAP3K11 ENSG00000255404 KAT5 RNASEH2C SNX32 CFL1 SIPA1 MUS81 SART1 PCNX3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAP3K11 on UCSC Golden Path with GeneCards custom track

Promoters for MAP3K11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000563873 482 3801 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for MAP3K11 Gene

Chromosome:
11
Start:
65,597,755 bp from pter
End:
65,615,382 bp from pter
Size:
17,628 bases
Orientation:
Minus strand

Genomic View for MAP3K11 Gene

Genes around MAP3K11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K11 Gene

Proteins for MAP3K11 Gene

  • Protein details for MAP3K11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16584-M3K11_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 11
    Protein Accession:
    Q16584
    Secondary Accessions:
    • B4DS76
    • Q53H00
    • Q59F06
    • Q6P2G4

    Protein attributes for MAP3K11 Gene

    Size:
    847 amino acids
    Molecular mass:
    92688 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer; undergoes dimerization during activation. Interacts with MAP2K4/MKK4. Interacts with MAP2K7/MKK7 (By similarity).
    SequenceCaution:
    • Sequence=BAD92892.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP3K11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP3K11 Gene

Selected DME Specific Peptides for MAP3K11 Gene

Q16584:
  • LAVAYGVA
  • MSAAGTYAWM
  • LWELLTGE
  • LRAKEKEL
  • EARLFAML
  • SGDEGWW
  • WMAPEVI
  • LAGRRVPPHVLVNWAVQ
  • VIHRDLK
  • EQLRRRE

Post-translational modifications for MAP3K11 Gene

  • Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-277 is likely to be the main autophosphorylation site. Phosphorylation of Ser-555 and Ser-556 is induced by CDC42.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP3K11 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAP3K11 (MLK3)
  • Abcam antibodies for MAP3K11

Domains & Families for MAP3K11 Gene

Graphical View of Domain Structure for InterPro Entry

Q16584

UniProtKB/Swiss-Prot:

M3K11_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K11: view

Function for MAP3K11 Gene

Molecular function for MAP3K11 Gene

GENATLAS Biochemistry:
mitogen activated protein (MAP/ERK) kinase kinase kinase 11,interacting specifically with the GTP bound form of RAC and CDC42,regulators of JNK pathway
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.
UniProtKB/Swiss-Prot Function:
Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.

Enzyme Numbers (IUBMB) for MAP3K11 Gene

Gene Ontology (GO) - Molecular Function for MAP3K11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,TAS 8183572
GO:0004674 protein serine/threonine kinase activity IDA,TAS 8195146
GO:0004706 JUN kinase kinase kinase activity ISS --
GO:0004709 MAP kinase kinase kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with MAP3K11: view
genes like me logo Genes that share phenotypes with MAP3K11: view

Animal Models for MAP3K11 Gene

MGI Knock Outs for MAP3K11:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAP3K11

miRNA for MAP3K11 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K11 Gene

Localization for MAP3K11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP3K11 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Location is cell cycle dependent.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP3K11 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MAP3K11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA,IBA --
GO:0005813 centrosome IDA 12529434
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with MAP3K11: view

Pathways & Interactions for MAP3K11 Gene

SuperPathways for MAP3K11 Gene

SuperPathway Contained pathways
1 RET signaling
2 G-protein signaling RAC1 in cellular process
3 MAPK signaling pathway
4 TGF-Beta Pathway
5 ERK Signaling
genes like me logo Genes that share pathways with MAP3K11: view

SIGNOR curated interactions for MAP3K11 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAP3K11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IMP 15258589
GO:0006468 protein phosphorylation IEA,IDA 11053428
GO:0007017 microtubule-based process IMP 12529434
GO:0007254 JNK cascade TAS 10799501
GO:0007256 activation of JNKK activity IEA --
genes like me logo Genes that share ontologies with MAP3K11: view

Drugs & Compounds for MAP3K11 Gene

(12) Drugs for MAP3K11 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
URMC-099 Pharma 0
Magnesium Nutra 0

(5) Additional Compounds for MAP3K11 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(1) ApexBio Compounds for MAP3K11 Gene

Compound Action Cas Number
URMC-099 1229582-33-5
genes like me logo Genes that share compounds with MAP3K11: view

Transcripts for MAP3K11 Gene

Unigene Clusters for MAP3K11 Gene

Mitogen-activated protein kinase kinase kinase 11:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K11 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ·
SP1: - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: -
SP8: -
SP9: - -
SP10: - - -
SP11: -
SP12:
SP13:
SP14:

ExUns: 12c ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for MAP3K11 Gene

GeneLoc Exon Structure for
MAP3K11
ECgene alternative splicing isoforms for
MAP3K11

Expression for MAP3K11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP3K11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP3K11 Gene

This gene is overexpressed in Whole Blood (x5.8).

Protein differential expression in normal tissues from HIPED for MAP3K11 Gene

This gene is overexpressed in Plasma (31.1), Lung (29.7), and Pancreatic juice (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP3K11 Gene



Protein tissue co-expression partners for MAP3K11 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAP3K11 Gene:

MAP3K11

SOURCE GeneReport for Unigene cluster for MAP3K11 Gene:

Hs.502872

mRNA Expression by UniProt/SwissProt for MAP3K11 Gene:

Q16584-M3K11_HUMAN
Tissue specificity: Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain.
genes like me logo Genes that share expression patterns with MAP3K11: view

Primer Products

Orthologs for MAP3K11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAP3K11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP3K11 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia MAP3K11 34 35
  • 89.64 (n)
cow
(Bos Taurus)
Mammalia MAP3K11 34 35
  • 89.3 (n)
rat
(Rattus norvegicus)
Mammalia Map3k11 34
  • 86.25 (n)
mouse
(Mus musculus)
Mammalia Map3k11 16 35 34
  • 86.17 (n)
oppossum
(Monodelphis domestica)
Mammalia MAP3K11 35
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP3K11 35
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii MAP3K11 35
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta slpr 36 35
  • 49 (a)
worm
(Caenorhabditis elegans)
Secernentea K11D12.10b 36
  • 28 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons HT1 34
  • 46.32 (n)
rice
(Oryza sativa)
Liliopsida Os06g0636600 34
  • 50.63 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8999 35
  • 29 (a)
OneToMany
Species where no ortholog for MAP3K11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MAP3K11 Gene

ENSEMBL:
Gene Tree for MAP3K11 (if available)
TreeFam:
Gene Tree for MAP3K11 (if available)

Paralogs for MAP3K11 Gene

Variants for MAP3K11 Gene

Sequence variations from dbSNP and Humsavar for MAP3K11 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10444358 -- 65,614,528(+) GCTAA(A/G)GATGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1051652 -- 65,597,867(-) GTCAT(C/T)TGGGG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs10526208 -- 65,614,687(+) TTTTC(-/CTTTTTT/TTTTCTTTTTT)CTTCT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs10750762 -- 65,600,834(+) GCAGC(A/G)GGTTG intron-variant
rs10750763 -- 65,600,963(+) CACCC(A/G)ACTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP3K11 Gene

Variant ID Type Subtype PubMed ID
nsv951018 CNV deletion 24416366
esv2761680 CNV gain 21179565
dgv1969n54 CNV loss 21841781

Variation tolerance for MAP3K11 Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.32; 41.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP3K11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP3K11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP3K11 Gene

Disorders for MAP3K11 Gene

Relevant External Links for MAP3K11

Human Genome Epidemiology (HuGE) Navigator
MAP3K11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP3K11

No disorders were found for MAP3K11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K11 Gene

Publications for MAP3K11 Gene

  1. MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain. (PMID: 8183572) Ing Y.L. … Lassam N.J. (Oncogene 1994) 2 3 4 22 64
  2. MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation. (PMID: 15258589) Chadee D.N. … Kyriakis J.M. (Nat. Cell Biol. 2004) 3 4 22 64
  3. A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization. (PMID: 12529434) Swenson K.I. … Means A.R. (Mol. Biol. Cell 2003) 3 4 22 64
  4. Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping. (PMID: 11969422) Vacratsis P.O. … Gallo K.A. (Biochemistry 2002) 3 4 22 64
  5. The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation. (PMID: 11053428) Leung I.W.L. … Lassam N.J. (J. Biol. Chem. 2001) 3 4 22 64

Products for MAP3K11 Gene

Sources for MAP3K11 Gene

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