Aliases for MAP3K11 Gene
External Ids for MAP3K11 Gene
Previous HGNC Symbols for MAP3K11 Gene
Previous GeneCards Identifiers for MAP3K11 Gene
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAP3K11 Gene
MAP3K11 (Mitogen-Activated Protein Kinase Kinase Kinase 11) is a Protein Coding gene. Among its related pathways are Reelin Pathway (Cajal-Retzius cells) and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein homodimerization activity and transferase activity, transferring phosphorus-containing groups. An important paralog of this gene is MAP3K9.
UniProtKB/Swiss-Prot for MAP3K11 Gene
Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.