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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MAP3K11 Gene

protein-coding GIFtS: 68
GCID: GC11M065365

mitogen-activated protein kinase kinase kinase 11

(Previous symbols: MLK3, PTK1)

Explore 17 diseases affiliated with
MAP3K11 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 11¹ ²		Src-Homology 3 Domain-Containing Proline-Rich Kinase² ³
MLK3¹ ² ³ ⁵		EC 2.7.11.25³ ⁸
PTK1¹ ² ³ ⁵		MLK-3²
SPRK¹ ² ³ ⁵		Protein-Tyrosine Kinase PTK1²
MEKK11¹ ²		SH3 Domain-Containing Proline-Rich Kinase²
Mixed Lineage Kinase 3² ³		EC 2.7.11⁸

External Ids:	HGNC: 6850¹	Entrez Gene: 4296²	Ensembl: ENSG00000173327⁷	OMIM: 600050⁵	UniProtKB: Q16584³

Export aliases for MAP3K11 gene to outside databases

Previous GC identifers: GC11M067881 GC11M067046 GC11M065615 GC11M065140 GC11M065121 GC11M061692

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAP3K11:

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain

and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive

regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and

beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: M3K11_HUMAN, Q16584

Function: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and

cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of

MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not

phosphorylate BRAF directly. Influences microtubule organization during the cell cycle

Gene Wiki entry for MAP3K11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MAP3K11 gene promoter:
NF-1 NF-1/L AP-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MAP3K11 promoter sequence

Search SABiosciences Chromatin IP Primers for MAP3K11

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1-q13.3 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1-q13.3

MAP3K11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K11 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M065365: view genomic region (about GC identifiers)

Start:	65,365,226 bp from pter	End:	65,382,853 bp from pter
Size:	17,628 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: M3K11_HUMAN, Q16584 (See protein sequence)

Recommended Name: Mitogen-activated protein kinase kinase kinase 11

Size: 847 amino acids; 92688 Da

Cofactor: Magnesium (By similarity)

Subunit: Homodimer; undergoes dimerization during activation. Interacts with MAP2K4/MKK4. Interacts with MAP2K7/MKK7

(By similarity)

Subcellular location: Cytoplasm, cytoskeleton, centrosome. Note=Location is cell cycle dependent

Sequence caution: Sequence=BAD92892.1; Type=Erroneous initiation;

Secondary accessions: Q53H00 Q59F06 Q6P2G4

Explore the universe of human proteins at neXtProt for MAP3K11: NX_Q16584

Post-translational modifications:

Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.

Thr-277 is likely to be the main autophosphorylation site. Phosphorylation of Ser-555 and Ser-556 is induced by CDC42¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q16584

4/10 DME Specific Peptides for MAP3K11 (Q16584) (see all 10)

SGDEGWW

WMAPEVI

VIHRDLK

EQLRRRE

MAP3K11 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002410.1

ENSEMBL proteins:

ENSP00000309597 ENSP00000432068 ENSP00000433886 ENSP00000431506 ENSP00000435970

ENSP00000435237

Human Recombinant Protein Products:

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	Uscn Proteins for MAP3K11

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	--	--
GO:0005737	cytoplasm	IEA	--
GO:0005813	centrosome	IDA	12529434
GO:0005874	microtubule	IDA	12529434

MAP3K11 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for MAP3K11

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MAP3K11 for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR017441 Protein_kinase_ATP_BS

IPR016231 MAPKKK9/10/11

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

IPR001452 SH3_domain

Graphical View of Domain Structure for InterPro Entry Q16584

ProtoNet protein and cluster: Q16584

1 Blocks protein family: IPB001452 SH3 domain signature

UniProtKB/Swiss-Prot: M3K11_HUMAN, Q16584

Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase

subfamily

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 SH3 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: M3K11_HUMAN, Q16584

Function: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and

cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of

MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not

phosphorylate BRAF directly. Influences microtubule organization during the cell cycle

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent

activation

Genatlas biochemistry entry for MAP3K11:

mitogen activated protein (MAP/ERK) kinase kinase kinase 11,interacting specifically with the GTP bound form of RAC and

CDC42,regulators of JNK pathway

Enzyme Numbers (IUBMB): EC 2.7.11.25¹ ² EC 2.7.11²

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		8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP3K11 (see all 54):
		hsa-miR-302d hsa-miR-520e hsa-miR-3938 hsa-miR-106a hsa-miR-372 hsa-miR-93 hsa-miR-302b hsa-miR-4326

		SwitchGear 3'UTR luciferase reporter plasmid: MAP3K11 3' UTR sequence

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In Situ Assay
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Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	TAS	8183572
GO:0004674	protein serine/threonine kinase activity	IDA	8195146
GO:0004706	JUN kinase kinase kinase activity	ISS	--
GO:0004709	MAP kinase kinase kinase activity	--	--
GO:0004713	protein tyrosine kinase activity	IEA	--

MAP3K11 for ontologies About GeneDecksing

6 GenomeRNAi human phenotypes for MAP3K11:

Decreased focal adhesion (FA)	Decreased substrate adherent c	Increased cell death in HCC-19	Increased circadian period len
Increased viability after born	Weaker migration

Animal Models:
Mouse knock-out Map3k11^tm1Rjd for MAP3K11
6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Map3k11):

cellular	craniofacial	homeostasis/metabolism	immune system	integument
mortality/aging

MAP3K11 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-protein signaling_RAC1 in cellular process

G-protein signaling_RAC1 in cellular process	1.00	Cytoskeleton remodeling CDC42 in cellular processes	0.37
G-protein signaling RAC1 in cellular process	1.00	RAC1 signaling pathway	0.34
Cytoskeleton remodeling_CDC42 in cellular processes	0.37	CDC42 signaling events	0.17

Signal transduction_JNK pathway

Signal transduction_JNK pathway

1.00

Signal transduction JNK pathway

0.98

Transcription CREB pathway

Transcription CREB pathway

1.00

Transcription_CREB pathway

0.93

Rho Family GTPases

Rho Family GTPases

1.00

MAPK Signaling

0.51

MAPK signaling pathway

MAPK signaling pathway

1.00

MAPK signaling pathway

0.50

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 EMD Millipore Pathways for MAP3K11 (see all 6)

	G-protein signaling RAC1 in cellular process
	Cytoskeleton remodeling CDC42 in cellular processes
	Transcription CREB pathway
	Signal transduction JNK pathway
	Development FGFR signaling pathway

5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP3K11 (see all 13)

	MAPK Signaling
	STAT3 Pathway
	CDC42 Pathway
	JNK Pathway
	TNFR2 Pathway

1 Cell Signaling Technology (CST) Pathway for MAP3K11

MAP Kinase Signaling

5/7 GeneGo (Thomson Reuters) Pathways for MAP3K11 (see all 7)

	Development FGF-family signaling
	Signal transduction JNK pathway
	G-protein signaling RAC1 in cellular process
	Cytoskeleton remodeling CDC42 in cellular processes
	Transcription CREB pathway

5/6 BioSystems Pathways for MAP3K11 (see all 6)

	MAPK signaling pathway
	Insulin Signaling
	RAC1 signaling pathway
	IFN-gamma pathway
	CDC42 signaling events

1 PharmGKB Pathway for MAP3K11

Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for MAP3K11):

MAPK signaling pathway

MAP3K11 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MAP3K11

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/54 Interacting proteins for MAP3K11 (Q16584^{1, 2, 3} ENSP00000309597⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 54)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDC42	P60953¹^,³, ENSP00000314458⁴	EBI-49961,EBI-81752 I2D: score=3 STRING: ENSP00000314458
MAP4K1	Q92918²^,³, ENSP00000380066⁴	MINT-7213051 I2D: score=5 STRING: ENSP00000380066
CHUK	O15111³, ENSP00000359424⁴	I2D: score=4 STRING: ENSP00000359424
COPS5	Q92905³, ENSP00000350512⁴	I2D: score=3 STRING: ENSP00000350512
KIF3A	Q9Y496³, ENSP00000368020⁴	I2D: score=3 STRING: ENSP00000368020

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000080	G1 phase of mitotic cell cycle	IMP	15258589
GO:0000187	activation of MAPK activity	IMP	15258589
GO:0006468	protein phosphorylation	IDA	11053428
GO:0007017	microtubule-based process	IMP	12529434
GO:0007254	JNK cascade	TAS	10799501

MAP3K11 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MAP3K11 for compounds About GeneDecksing

EMD Millipore small molecules for MAP3K11:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MAP3K11

3 HMDB Compounds for MAP3K11 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

10/13 Novoseek chemical compound relationships for MAP3K11 gene (see all 13) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
kt 7515	91.8	5	12388555 (2), 12354290 (1), 16785569 (1)
threonine	57.2	12	9003778 (1), 10799501 (1), 11590155 (1), 11713255 (1) (see all 7)
leucine	51.6	12	9829970 (3), 16253996 (1), 18199767 (1), 15069087 (1) (see all 8)
serine	46.9	12	9003778 (1), 10799501 (1), 11590155 (1), 11713255 (1) (see all 7)
phosphatidylinositol	32.1	1	14504284 (1)
proline	30.2	2	11590155 (1), 8195146 (1)
isoleucine	25.8	2	9829970 (2)
ceramide	21	14	12504027 (4)
tyrosine	20.8	2	15467451 (1), 9829970 (1)
gtp	8.19	1	7493928 (1)

Search CenterWatch for drugs/clinical trials and news about MAP3K11 / M3K11

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MAP3K11 gene:

NM_002419.3

Unigene Cluster for MAP3K11:

Mitogen-activated protein kinase kinase kinase 11

Hs.502872 [show with all ESTs]

Unigene Representative Sequence: BC064543

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000309100(uc001oew.3) ENST00000532507(uc001oev.3) ENST00000530153(uc001oex.1 uc010rol.2)

ENST00000524848 ENST00000534432 ENST00000526647 ENST00000524856 ENST00000533032

ENST00000530949 ENST00000526293 ENST00000529839 ENST00000534110 ENST00000527304

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		SwitchGear 3'UTR luciferase reporter plasmid: MAP3K11 3' UTR sequence

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Additional cDNA sequence:

AK090614.1 AK222781.1 AK299609.1 AK310986.1 AK315557.1 AK316032.1 BC011263.2 BC064543.1

L32976.1 U07747.1

14 DOTS entries:

DT.411131 DT.97809626 DT.100656865 DT.100752452 DT.100752455 DT.100752453 DT.120745956 DT.120745959

DT.92431194 DT.100752451 DT.100752459 DT.95108831 DT.120745961 DT.75123986

24/160 AceView cDNA sequences (see all 160):

BM967126 BQ941183 BQ436921 BX118590 BQ674554 BQ227232 CR608023 BQ225230

AU119385 AW600310 BM915402 BU628843 BM925687 BC064543 BC011263 BF984547

NM_002419 L32976 CA393665 U07747 BM552088 BG482413 AK057256 AW614105

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K11 (see all 14) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	·	8c	·	8d	^	9a	·	9b	·	9c	^	10a	·	10b	·	10c	^	11	^	12a	·	12b	·
SP1:																																			-						-				-
SP2:									-																-		-		-						-
SP3:																									-		-		-						-						-
SP4:																									-		-		-						-
SP5:																									-		-		-						-						-				-		-

ExUns:	12c	^	13	^	14
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for MAP3K11

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MAP3K11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACCTCCTGC

About this image
See MAP3K11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAP3K11

SOURCE GeneReport for Unigene cluster: Hs.502872

UniProtKB/Swiss-Prot: M3K11_HUMAN, Q16584

Tissue specificity: Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and

kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain

SABiosciences Expression via Pathway-Focused PCR Array including MAP3K11:

Cytoskeleton Regulators in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAP3K11 gene from 4/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	CABZ01078394.1⁶	--	67(a)	1 ↔ 1	7(747449-751076)
fruit fly (Drosophila melanogaster)	Insecta	slpr³	JNK cascade protein kinase	49(a)		7D17 --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G35050⁶ AT3G24715⁶ (see all 7)	octicosapeptide/Phox/Be.1 domain-containing protei... octicosapeptide/Phox/Bem1p domain-containing prote... (see all 7)	9(a) 9(a) (see all 7)	many ↔ many many ↔ many (see all 7)	2(14768724-14775035) 3(9025849-9029948)
rice (Oryza sativa)	Liliopsida	-- -- (see all 5)	protein kinase domain containing protein, expresse... protein kinase domain containing protein, expresse... (see all 5)	9(a) 9(a) (see all 5)	many ↔ many many ↔ many (see all 5)	7(14722116-14730584) 6(26398279-26404234)

ENSEMBL Gene Tree for MAP3K11 (if available)
TreeFam Gene Tree for MAP3K11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MAP3K11 gene

MAP3K12² KIAA1804² RAF1² KSR2² KSR1² MOS² BRAF² MAP3K10²

MAP3K9² ARAF² MAP3K7² MAP3K7CL² TNNI3K² ZAK² MAP3K13² ILK²

18/52 SIMAP similar genes for MAP3K11 using alignment to 6 protein entries: M3K11_HUMAN (see all proteins) (see all similar genes):

MAP3K13 PKN2 MARK4 GRK5 MAP3K9 NEK5

MLK4 DAPK2 RPS6KA1 BRAF PRKACB ULK1

CAMKK2 MAP3K12 PRKACA SH3GL2 BLK MELK

MAP3K11 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10896020^1,2	A,	--	61691743(+)	`TTTTTG/TTTTTT`	4	--	us2k¹		0	--	--	--	--
rs111340550^1,2		--	61692065(+)	`ACCAAG/CGCTGG`	4	--	us2k¹		1		CSA	2
rs201216651^1,2		--	65364777(+)	`TTTTT-/GTTTTT`	1	--	ds500¹		0	--	--	--	--
rs10896021^1,2	C,A,	--	65364911(+)	`TGGGAC/TTACAG`	1	--	ds500¹		1		NA	2
rs187335911^1,2		--	65364965(+)	`GATGGA/GGTTTC`	1	--	ds500¹		0	--	--	--	--
rs111242671^1,2	C,	--	65364984(+)	`CCAGGTTGGTC/- TTGAA`	5	--	us2k¹ ds500¹		1		CSA	2
rs11282819^1,2	C	--	65364987(+)	`GGTTGGTCTTG/- AACTC`	1	--	ds500¹		1		NA	2
rs12419237^1,2	C,F,H,	--	65365077(+)	`GAGCCT/CTGAAT`	1	--	ds500¹		6		NA WA EA	366
rs11227234^1,2	C,F,H,	--	65365171(+)	`ACCAGG/TGTTGT`	1	--	ds500¹		23		NS EA NA WA	2762
rs948577^1,2	C,F,A,H,	--	65365318(-)	`TCTGGA/GTGCCT`	1	--	ut3¹ ese³		24		EA MN NS NA WA	2898

HapMap Linkage Disequilibrium report for MAP3K11 (65365226 - 65382853 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MAP3K11: --

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QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP3K11

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MAP3K11 for disorders           About GeneDecksing

OMIM gene information: 600050    OMIM disorders: --

17 diseases for MAP3K11:    About MalaCards

brain injury neurodegenerative disease brain ischemia ischemia

rheumatoid arthritis dementia neurofibromatosis crohn's disease

cerebritis arthritis gastric cancer prostate cancer

breast cancer prostatitis immunodeficiency pancreatitis

neuronitis

1 disease from the University of Copenhagen DISEASES database for MAP3K11:

Brain ischemia

7 Novoseek disease relationships for MAP3K11 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ischemic brain injury	61.6	1	17348686 (1)
cerebral ischemia	31	4	17348686 (1), 16831194 (1), 20219637 (1)
necrosis	12.8	8	10713178 (2), 19918265 (1), 19586614 (1), 15001580 (1) (see all 5)
ischemia	0	1	17348686 (1)
neurodegenerative diseases	0	1	11438570 (1)
dementia	0	1	12354290 (1)
tumors	0	11	10713178 (2), 15467451 (1), 19918265 (1), 15001580 (1) (see all 7)

Human Genome Epidemiology (HuGE) Navigator: MAP3K11 (1 document)

Export disorders for MAP3K11 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MAP3K11 gene, integrated from 9 sources (see all 118):
(articles sorted by number of sources associating them with MAP3K11)

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MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain. (PubMed id 8183572)^{1, 2, 3, 9} Ing Y.L....Lassam N.J. (1994)
Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK- 3. (PubMed id 9829970)^{1, 2, 9} Leung I.W.L. and Lassam N.J. (1998)
A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization. (PubMed id 12529434)^{1, 2, 9} Swenson K.I.... Means A.R. (2003)
Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping. (PubMed id 11969422)^{1, 2, 9} Vacratsis P.O.... Gallo K.A. (2002)
MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation. (PubMed id 15258589)^{1, 2, 9} Chadee D.N. and Kyriakis J.M. (2004)
Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity. (PubMed id 8195146)^{1, 2, 9} Gallo K.A.... Godowski P.J. (1994)
The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation. (PubMed id 11053428)^{1, 2, 9} Leung I.W.L. and Lassam N.J. (2001)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13. (PubMed id 9267807)^{1, 3} Smith C.M....Gerhard D.S. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4296	HGNC: 6850	AceView: MAP3K11	Ensembl:ENSG00000173327	euGenes: HUgn4296
ECgene: MAP3K11	Kegg: 4296	H-InvDB: MAP3K11

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MAP3K11	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MAP3K11	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MAP3K11 gene
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Patent Information for MAP3K11 gene:
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MAP3K11 Gene

mitogen-activated protein kinase kinase kinase 11

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MAP3K11 Gene

mitogen-activated protein kinase kinase kinase 11

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