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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP3K11 Gene

protein-coding   GIFtS: 71
GCID: GC11M065365

Mitogen-Activated Protein Kinase Kinase Kinase 11


(Previous symbols: MLK3, PTK1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 111 2     EC 2.7.11.253 8
MLK31 2 3 5     MEKK112
PTK11 2 3 5     MLK-32
SPRK2 3 5     Protein-Tyrosine Kinase PTK12
Mixed Lineage Kinase 32 3     SH3 Domain-Containing Proline-Rich Kinase2
Src-Homology 3 Domain-Containing Proline-Rich Kinase2 3     EC 2.7.118

External Ids:    HGNC: 68501   Entrez Gene: 42962   Ensembl: ENSG000001733277   OMIM: 6000505   UniProtKB: Q165843   

Export aliases for MAP3K11 gene to outside databases

Previous GC identifers: GC11M067881 GC11M067046 GC11M065615 GC11M065140 GC11M065121 GC11M061692


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAP3K11 Gene:
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3
domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as
a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB
kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho
family GTPases and CDC42. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAP3K11 Gene: 
MAP3K11 (mitogen-activated protein kinase kinase kinase 11) is a protein-coding gene. Diseases associated with MAP3K11 include brain injury, and brain ischemia, and among its related super-pathways are Development FGF-family signaling and MAPK signaling pathway. GO annotations related to this gene include protein serine/threonine kinase activity and protein homodimerization activity. An important paralog of this gene is FPGT-TNNI3K.

UniProtKB/Swiss-Prot: M3K11_HUMAN, Q16584
Function: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen
and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of
MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does
not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle

Gene Wiki entry for MAP3K11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP3K11 gene promoter:
         NF-1   NF-1/L   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): MAP3K11 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP3K11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1-q13.3   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1-q13.3

MAP3K11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K11 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M065365:  view genomic region     (about GC identifiers)

Start:
65,365,226 bp from pter      End:
65,382,853 bp from pter
Size:
17,628 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: M3K11_HUMAN, Q16584 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 11  
Size: 847 amino acids; 92688 Da
Cofactor: Magnesium (By similarity)
Subunit: Homodimer; undergoes dimerization during activation. Interacts with MAP2K4/MKK4. Interacts with
MAP2K7/MKK7 (By similarity)
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Location is cell
cycle dependent
Sequence caution: Sequence=BAD92892.1; Type=Erroneous initiation;
Secondary accessions: Q53H00 Q59F06 Q6P2G4

Explore the universe of human proteins at neXtProt for MAP3K11: NX_Q16584

Explore proteomics data for MAP3K11 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.
    Thr-277 is likely to be the main autophosphorylation site. Phosphorylation of Ser-555 and Ser-556 is induced by
    CDC42
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16584

  • 4/10 DME Specific Peptides for MAP3K11 (Q16584) (see all 10)
     SGDEGWW  WMAPEVI  VIHRDLK  EQLRRRE 

    MAP3K11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAP3K11 Protein Expression
    REFSEQ proteins: NP_002410.1  
    ENSEMBL proteins: 
     ENSP00000309597   ENSP00000432068   ENSP00000433886   ENSP00000431506   ENSP00000435970  
     ENSP00000435237  

    Human Recombinant Protein Products for MAP3K11: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAP3K11 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome IDA12529434
    GO:0005874microtubule IDA12529434

    MAP3K11 for ontologies           About GeneDecksing



    MAP3K11 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MAP3K: Mitogen-activated protein kinase cascade / Kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase 11 
    MLK subfamily

    5/10 InterPro protein domains (see all 10):
     IPR017441 Protein_kinase_ATP_BS
     IPR016231 MAPKKK9/10/11
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q16584

    ProtoNet protein and cluster: Q16584

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: M3K11_HUMAN, Q16584
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH3 domain


    MAP3K11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M3K11_HUMAN, Q16584
    Function: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen
    and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of
    MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does
    not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Homodimerization via the leucine zipper domains is required for autophosphorylation and
    subsequent activation

         Genatlas biochemistry entry for MAP3K11:
    mitogen activated protein (MAP/ERK) kinase kinase kinase 11,interacting specifically with the GTP bound form of
    RAC and CDC42,regulators of JNK pathway

         Enzyme Numbers (IUBMB): EC 2.7.11.251 2 EC 2.7.112

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS10799501
    GO:0004674protein serine/threonine kinase activity IDA8195146
    GO:0004706JUN kinase kinase kinase activity ISS--
    GO:0004709MAP kinase kinase kinase activity ----
    GO:0004713protein tyrosine kinase activity IEA--
         
    MAP3K11 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for MAP3K11:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased cell death in HCC-19  Increased circadian period len 
     Increased viability after born  Weaker migration 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Map3k11):
     cellular  craniofacial  homeostasis/metabolism  immune system  integument 
     mortality/aging 

    MAP3K11 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Map3k11tm1Rjd for MAP3K11

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAP3K11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAP3K11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP3K11 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP3K11 

    miRNA
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    miRTarBase miRNAs that target MAP3K11:
    hsa-mir-199a-5p (MIRT005873)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP3K11
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP3K11 (see all 54):
    hsa-miR-302d hsa-miR-520e hsa-miR-3938 hsa-miR-106a hsa-miR-372 hsa-miR-93 hsa-miR-302b hsa-miR-4326
    SwitchGear 3'UTR luciferase reporter plasmidMAP3K11 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAP3K11 About   (see all 24)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development FGF-family signaling
    Development FGF-family signaling0.63
    Development FGFR signaling pathway0.50
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3Rho Family GTPases
    Rho Family GTPases0.61
    MAPK Signaling0.58
    4TGF-Beta Pathway
    MAPK Family Pathway0.60
    JNK Pathway0.51
    5Cytoskeleton remodeling CDC42 in cellular processes
    G-protein signaling RAC1 in cellular process0.37
    Cytoskeleton remodeling CDC42 in cellular processes0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 EMD Millipore Pathways for MAP3K11 (see all 6)
        G-protein signaling RAC1 in cellular process
    Cytoskeleton remodeling CDC42 in cellular processes
    Transcription CREB pathway
    Signal transduction JNK pathway
    Development FGFR signaling pathway

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP3K11 (see all 13)
        MAPK Signaling
    STAT3 Pathway
    CDC42 Pathway
    JNK Pathway
    TNFR2 Pathway

    1 Cell Signaling Technology (CST) Pathway for MAP3K11
        MAP Kinase Signaling

    5/7 GeneGo (Thomson Reuters) Pathways for MAP3K11 (see all 7)
        Development FGF-family signaling
    Signal transduction JNK pathway
    G-protein signaling RAC1 in cellular process
    Cytoskeleton remodeling CDC42 in cellular processes
    Transcription CREB pathway

    5/6 BioSystems Pathways for MAP3K11 (see all 6)
        MAPK signaling pathway
    Insulin Signaling
    CDC42 signaling events
    IFN-gamma pathway
    Reelin signaling pathway


    1 PharmGKB Pathway for MAP3K11
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    2         Kegg Pathways  (Kegg details for MAP3K11):
        MAPK signaling pathway
    Non-alcoholic fatty liver disease (NAFLD)


    MAP3K11 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP3K11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/55 Interacting proteins for MAP3K11 (Q165841, 2, 3 ENSP000003095974) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC42P609531, 3, ENSP000003144584EBI-49961,EBI-81752 I2D: score=3 STRING: ENSP00000314458
    MAP4K1Q929182, 3, ENSP000003800664MINT-7213051 I2D: score=5 STRING: ENSP00000380066
    CHUKO151113, ENSP000003594244I2D: score=4 STRING: ENSP00000359424
    COPS5Q929053, ENSP000003505124I2D: score=3 STRING: ENSP00000350512
    KIF3AQ9Y4963, ENSP000003680204I2D: score=3 STRING: ENSP00000368020
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000080G1 phase of mitotic cell cycle IMP15258589
    GO:0000187activation of MAPK activity IMP15258589
    GO:0006468protein phosphorylation IDA11053428
    GO:0007017microtubule-based process IMP12529434
    GO:0007254JNK cascade TAS10799501

    MAP3K11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP3K11 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAP3K11:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP3K11 (M3K11)

    3 HMDB Compounds for MAP3K11    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    10/13 Novoseek inferred chemical compound relationships for MAP3K11 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kt 7515 91.8 5 12388555 (2), 12354290 (1), 16785569 (1)
    threonine 57.2 12 9003778 (1), 10799501 (1), 11590155 (1), 11713255 (1) (see all 7)
    leucine 51.6 12 9829970 (3), 16253996 (1), 18199767 (1), 15069087 (1) (see all 8)
    serine 46.9 12 9003778 (1), 10799501 (1), 11590155 (1), 11713255 (1) (see all 7)
    phosphatidylinositol 32.1 1 14504284 (1)
    proline 30.2 2 11590155 (1), 8195146 (1)
    isoleucine 25.8 2 9829970 (2)
    ceramide 21 14 12504027 (4)
    tyrosine 20.8 2 15467451 (1), 9829970 (1)
    gtp 8.19 1 7493928 (1)

    Search CenterWatch for drugs/clinical trials and news about MAP3K11 / M3K11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for MAP3K11 gene: 
    NM_002419.3  

    Unigene Cluster for MAP3K11:

    Mitogen-activated protein kinase kinase kinase 11
    Hs.502872  [show with all ESTs]
    Unigene Representative Sequence: BC064543
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309100(uc001oew.3) ENST00000532507(uc001oev.3) ENST00000530153(uc001oex.1 uc010rol.2)
    ENST00000524848 ENST00000534432 ENST00000526647 ENST00000524856 ENST00000533032
    ENST00000530949 ENST00000526293 ENST00000529839 ENST00000534110 ENST00000527304


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    Additional mRNA sequence: 

    AK090614.1 AK222781.1 AK299609.1 AK310986.1 AK315557.1 AK316032.1 BC011263.2 BC064543.1 
    L32976.1 U07747.1 

    14 DOTS entries:

    DT.411131  DT.97809626  DT.100656865  DT.100752452  DT.100752455  DT.100752453  DT.120745956  DT.120745959 
    DT.92431194  DT.100752451  DT.100752459  DT.95108831  DT.120745961  DT.75123986 

    24/160 AceView cDNA sequences (see all 160):

    CA393665 AW600310 BM915402 BF984547 NM_002419 BQ225230 U07747 AU119385 
    BQ941183 BQ436921 BX118590 BM967126 L32976 BQ674554 BC011263 BM925687 
    BQ227232 BU628843 CR608023 BC064543 BM552088 BU661670 CA394583 R80671 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K11 (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ·
    SP1:                                                                                                        -                 -           -                     
    SP2:                          -                                               -     -     -                 -                                                   
    SP3:                                                                          -     -     -                 -                 -                                 
    SP4:                                                                          -     -     -                 -                                                   
    SP5:                                                                          -     -     -                 -                 -           -     -               

    ExUns: 12c ^ 13 ^ 14
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for MAP3K11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP3K11 expression in normal human tissues (normalized intensities)      MAP3K11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCTCCTGC
    MAP3K11 Expression
    About this image


    MAP3K11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Uterus
             uterus, post-menopause ; glandular cells   

    See MAP3K11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP3K11

    SOURCE GeneReport for Unigene cluster: Hs.502872

    UniProtKB/Swiss-Prot: M3K11_HUMAN, Q16584
    Tissue specificity: Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver,
    heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain

        SABiosciences Expression via Pathway-Focused PCR Array including MAP3K11: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MAP3K11 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map3k111 , 5 mitogen-activated protein kinase kinase kinase 111, 5 86.33(n)1
    94.92(a)1
      19 (4.34 cM)5
    264031  NM_022012.31  NP_071295.21 
     56891315 
    lizard
    (Anolis carolinensis)
    Reptilia MAP3K116
    Uncharacterized protein
    75(a)
    1 ↔ 1
    GL343360.1(270345-279745)
    zebrafish
    (Danio rerio)
    Actinopterygii MAP3K116
    mitogen-activated protein kinase kinase kinase 11
    69(a)
    1 ↔ 1
    7(747449-751076)
    fruit fly
    (Drosophila melanogaster)
    Insecta slpr3 JNK cascade protein kinase 49(a)   7D17   --


    ENSEMBL Gene Tree for MAP3K11 (if available)
    TreeFam Gene Tree for MAP3K11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP3K11 gene
    FPGT-TNNI3K2  MAP3K122  KIAA18042  RAF12  KSR22  KSR12  MOS2  BRAF2  
    MAP3K102  MAP3K92  ARAF2  MAP3K72  TNNI3K2  ZAK2  MAP3K132  ILK2  
    18/55 SIMAP similar genes for MAP3K11 using alignment to 6 protein entries:     M3K11_HUMAN (see all proteins) (see all similar genes):
    MAP3K10    MAP3K13    PKN2    MARK4    GRK5    MAP3K9
    NEK5    MLK4    RPS6KA1    BRAF    ULK1    CAMKK2
    MAP3K12    PRKACA    SH3GL2    BLK    LRRK1    AKT2

    MAP3K11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/367 SNPs in MAP3K11 are shown (see all 367)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1468314771,2
    --65365473(+) CACCCC/GAGCAG 1 -- ut310--------
    rs1997016351,2
    --65365643(+) CCAAA-/GGGGGG 1 -- ut310--------
    rs1922849591,2
    --65365662(+) CCTGGA/GGAAAC 1 -- ut310--------
    rs2000983301,2
    C--65365939(-) CCTTCC/TCCCCT 2 S syn10--------
    rs79461151,2
    C,F,A,H--65366192(+) CCCATG/CTGCAC 1 -- int111Minor allele frequency- C:0.20NS EA NA CSA WA 778
    rs79326161,2
    C,F,A,H--65366240(+) CTCCGT/CGGTGC 1 -- int119Minor allele frequency- C:0.17NS EA NA CSA WA 2342
    rs1838968561,2
    --65366391(+) CATCCA/GGGAGC 1 -- int10--------
    rs1433836151,2
    --65366490(+) TGCTAC/TGATTA 1 -- int10--------
    rs1881125621,2
    --65366491(+) GCTACA/GATTAT 1 -- int10--------
    rs112272351,2
    C,F--65366495(+) CGATTA/TTGATT 1 -- int16Minor allele frequency- T:0.21NA WA EA 364

    HapMap Linkage Disequilibrium report for MAP3K11 (65365226 - 65382853 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for MAP3K11 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv897723CNV Loss21882294
    dgv1175n71CNV Loss21882294
    nsv897739CNV Loss21882294
    dgv1180n71CNV Loss21882294
    nsv897736CNV Loss21882294
    nsv897730CNV Loss21882294
    dgv1176n71CNV Loss21882294
    dgv1181n71CNV Loss21882294
    dgv1179n71CNV Loss21882294
    nsv897718CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600050    OMIM disorders: --

    16 diseases for MAP3K11:    About MalaCards
    brain injury    brain ischemia    ischemia    neurofibromatosis
    dementia    crohn's disease    cerebritis    gastric cancer
    rheumatoid arthritis    arthritis    prostate cancer    ovarian cancer
    prostatitis    neuronitis    breast cancer    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for MAP3K11:
    Brain ischemia

    MAP3K11 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    7 Novoseek inferred disease relationships for MAP3K11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ischemic brain injury 61.6 1 17348686 (1)
    cerebral ischemia 31 4 17348686 (1), 16831194 (1), 20219637 (1)
    necrosis 12.8 8 10713178 (2), 19918265 (1), 19586614 (1), 15001580 (1) (see all 5)
    ischemia 0 1 17348686 (1)
    neurodegenerative diseases 0 1 11438570 (1)
    dementia 0 1 12354290 (1)
    tumors 0 11 10713178 (2), 15467451 (1), 19918265 (1), 15001580 (1) (see all 7)

    Human Genome Epidemiology (HuGE) Navigator: MAP3K11 (1 document)

    Export disorders for MAP3K11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP3K11 gene, integrated from 9 sources (see all 123):
    (articles sorted by number of sources associating them with MAP3K11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain. (PubMed id 8183572)1, 2, 3, 9 Ing Y.L....Lassam N.J. (1994)
    2. Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK- 3. (PubMed id 9829970)1, 2, 9 Leung I.W.L. and Lassam N.J. (1998)
    3. A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization. (PubMed id 12529434)1, 2, 9 Swenson K.I.... Means A.R. (2003)
    4. Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping. (PubMed id 11969422)1, 2, 9 Vacratsis P.O.... Gallo K.A. (2002)
    5. MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation. (PubMed id 15258589)1, 2, 9 Chadee D.N. and Kyriakis J.M. (2004)
    6. Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity. (PubMed id 8195146)1, 2, 9 Gallo K.A.... Godowski P.J. (1994)
    7. The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation. (PubMed id 11053428)1, 2, 9 Leung I.W.L. and Lassam N.J. (2001)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13. (PubMed id 9267807)1, 3 Smith C.M....Gerhard D.S. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4296 HGNC: 6850 AceView: MAP3K11 Ensembl:ENSG00000173327 euGenes: HUgn4296
    ECgene: MAP3K11 Kegg: 4296 H-InvDB: MAP3K11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP3K11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP3K11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAP3K11 gene:
    Search GeneIP for patents involving MAP3K11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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