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MAP3K10 Gene

protein-coding   GIFtS: 65
GCID: GC19P040697

Mitogen-Activated Protein Kinase Kinase Kinase 10


(Previous symbol: MLK2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 101 2     MKN28 Kinase1 2
MLK21 2 3 5     Protein Kinase MST2 3
Mixed Lineage Kinase 21 2 3     EC 2.7.11.253 8
MST2 3 5     MEKK102
MKN28 Derived Nonreceptor_type Serine/Threonine Kinase1 2     EC 2.7.118

External Ids:    HGNC: 68491   Entrez Gene: 42942   Ensembl: ENSG000001307587   OMIM: 6001375   UniProtKB: Q027793   

Export aliases for MAP3K10 gene to outside databases

Previous GC identifers: GC19P041337 GC19P041089 GC19P045373 GC19P045389 GC19P037132


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP3K10 Gene:
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to
activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases.
This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth
factor (NGF) induced neuronal apoptosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAP3K10 Gene:
MAP3K10 (mitogen-activated protein kinase kinase kinase 10) is a protein-coding gene. Diseases associated with MAP3K10 include alexander disease, and differentiating neuroblastoma. GO annotations related to this gene include protein kinase activity and protein homodimerization activity. An important paralog of this gene is FPGT-TNNI3K.

UniProtKB/Swiss-Prot: M3K10_HUMAN, Q02779
Function: Activates the JUN N-terminal pathway (By similarity)

Gene Wiki entry for MAP3K10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP3K10 gene promoter:
         Spz1   AML1a   MIF-1   CUTL1   C/EBPalpha   CHOP-10   AP-2beta   ZIC2/Zic2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAP3K10 promoter sequence
   Search Chromatin IP Primers for MAP3K10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP3K10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

MAP3K10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K10 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P040697:  view genomic region     (about GC identifiers)

Start:
40,697,651 bp from pter      End:
40,721,482 bp from pter
Size:
23,832 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: M3K10_HUMAN, Q02779 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 10  
Size: 954 amino acids; 103694 Da
Cofactor: Magnesium (By similarity)
Subunit: Homodimer (By similarity)
1 PDB 3D structure from and Proteopedia for MAP3K10:
2RF0 (3D)    
Secondary accessions: Q12761 Q14871

Explore the universe of human proteins at neXtProt for MAP3K10: NX_Q02779

Explore proteomics data for MAP3K10 at MOPED

Post-translational modifications: 

  • Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation
    (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAP3K10 (Q02779) (see all 13)
     FPRLPDP  SGDEGWW  WMAPEVI  ELTLRRG 


    See MAP3K10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002437.2  
    ENSEMBL proteins: 
     ENSP00000253055   ENSP00000471116   ENSP00000473021   ENSP00000471916  

    MAP3K10 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MAP3K10
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    Novus Biologicals MAP3K10 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAP3K10

    MAP3K10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for MAP3K10
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    ThermoFisher Antibodies for MAP3K10
    LSBio Antibodies in human, mouse, rat for MAP3K10

    MAP3K10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MAP3K10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAP3K10
    Cloud-Clone Corp. CLIAs for MAP3K10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAP3K: Mitogen-activated protein kinase cascade / Kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase 10
    MLK subfamily

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR016231 MAPKKK9/10/11
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q02779

    ProtoNet protein and cluster: Q02779

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: M3K10_HUMAN, Q02779
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH3 domain


    MAP3K10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M3K10_HUMAN, Q02779
    Function: Activates the JUN N-terminal pathway (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Homodimerization via the leucine zipper domains is required for autophosphorylation and
    subsequent activation (By similarity)

         Genatlas biochemistry entry for MAP3K10:
    mitogen activated protein (MAP/ERK) kinase kinase kinase 10

         Enzyme Numbers (IUBMB): EC 2.7.11.251 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity ISS--
    GO:0004672protein kinase activity TAS10801775
    GO:0004674protein serine/threonine kinase activity IDA19801649
    GO:0004706JUN kinase kinase kinase activity ISS--
    GO:0004709MAP kinase kinase kinase activity ----
         
    MAP3K10 for ontologies           About GeneDecksing


    Phenotypes:
         10 GenomeRNAi human phenotypes for MAP3K10:
     Cell division defect  Decreased TP53 protein express  Decreased substrate adherent c  Increased S DNA content 
     Increased cell death HMECs cel  Increased cell death in breast  Increased colony dispersion (i  Increased number of cells in m 
     Increased number of mitotic ce  Upregulation of Wnt/beta-caten 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Map3k10):
     digestive/alimentary  embryogenesis  homeostasis/metabolism  immune system  mortality/aging 
     muscle  nervous system  normal  renal/urinary system  reproductive system 

    MAP3K10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Map3k10tm1Dsd for MAP3K10

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAP3K10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAP3K10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP3K10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP3K10

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAP3K10:
    hsa-mir-484 (MIRT042327), hsa-mir-155-5p (MIRT007103), hsa-mir-181b-5p (MIRT005545)

    Block miRNA regulation of human, mouse, rat MAP3K10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP3K10 (see all 14):
    hsa-miR-647 hsa-miR-146b-3p hsa-miR-125a-5p hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-125b hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidMAP3K10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAP3K10
    Predesigned siRNA for gene silencing in human, mouse, rat MAP3K10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAP3K10

    Clone
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    OriGene clones in human, mouse for MAP3K10 (see all 7)
    OriGene ORF clones in mouse, rat for MAP3K10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAP3K10 (NM_002446)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP3K10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K10

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MAP3K10
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAP3K10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA18455992

    MAP3K10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP3K10 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Development EGFR signaling pathway
    Development EGFR signaling pathway0.57
    EGF Pathway0.39
    2ERK Signaling
    Rho Family GTPases0.61
    MAPK Signaling0.58
    3TGF-Beta Pathway
    MAPK Family Pathway0.60
    JNK Pathway0.51
    4Development HGF signaling pathway
    Development EGFR signaling via small GTPases0.44
    Development EGFR signaling via PIP30.40
    5Akt Signaling
    p38 Signaling0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAP3K10 (see all 11)
        MAPK Signaling
    STAT3 Pathway
    JNK Pathway
    TNFR2 Pathway
    NFAT and Cardiac Hypertrophy

    4 GeneGo (Thomson Reuters) Pathways for MAP3K10
        Development EGFR signaling via PIP3
    Development EGFR signaling pathway
    Signal transduction JNK pathway
    Development EGFR signaling via small GTPases

    2 BioSystems Pathways for MAP3K10
        Insulin Signaling
    p38 MAPK signaling pathway


        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP3K10: 
              Huntington's Disease in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAP3K10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAP3K10 (Q027793 ENSP000002530554) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000183311P074373I2D: score=1 
    ENSG00000224156P074373I2D: score=1 
    ENSG00000227739P074373I2D: score=1 
    ENSG00000229684P074373I2D: score=1 
    ENSG00000232421P074373I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006915apoptotic process TAS10801775
    GO:0007165signal transduction TAS10801775
    GO:0007224smoothened signaling pathway IMP18455992
    GO:0007254JNK cascade TAS10801775

    MAP3K10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAP3K10 (M3K10)

    3 HMDB Compounds for MAP3K10    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    4 Novoseek inferred chemical compound relationships for MAP3K10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 56.3 10 7731697 (3), 15069087 (1), 11416147 (1), 8536694 (1) (see all 6)
    threonine 50.8 4 7731697 (3), 19801649 (1)
    proline 42 3 7731697 (2), 11590155 (1)
    serine 37.9 4 7731697 (3), 19801649 (1)



    MAP3K10 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAP3K10 gene: 
    NM_002446.3  

    Unigene Cluster for MAP3K10:

    Mitogen-activated protein kinase kinase kinase 10
    Hs.466743  [show with all ESTs]
    Unigene Representative Sequence: X90846
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000253055(uc002ona.3) ENST00000593906 ENST00000594951 ENST00000593502
    ENST00000597986 ENST00000601702 ENST00000594569 ENST00000594791
    miRNA
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    Block miRNA regulation of human, mouse, rat MAP3K10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP3K10 (see all 14):
    hsa-miR-647 hsa-miR-146b-3p hsa-miR-125a-5p hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-125b hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidMAP3K10 3' UTR sequence
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAP3K10 (NM_002446)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K10
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAP3K10
      QuantiTect SYBR Green Assays in human, mouse, rat MAP3K10
      QuantiFast Probe-based Assays in human, mouse, rat MAP3K10

    Additional mRNA sequence: 

    X90846.1 Z48615.1 

    6 DOTS entries:

    DT.408555  DT.99988514  DT.121435342  DT.108565  DT.108566  DT.40110995 

    Selected AceView cDNA sequences (see all 58):

    BM764493 BU930875 BU633407 AL539199 BX103677 BM783445 AI831487 CR605472 
    NM_002446 BM784975 BX093966 AI814612 CD614834 BQ636998 Z48615 AI991621 
    BM805198 AW452931 CK903601 AI879161 AI878963 BF594729 BF514325 BM743825 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K10    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9
    SP1:                                                                                            -         
    SP2:                                                        -     -                                       
    SP3:                                -     -     -           -     -                                       
    SP4:                                      -     -                                                         
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for MAP3K10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAP3K10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGATTTGG
    MAP3K10 Expression
    About this image


    MAP3K10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
    MAP3K10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP3K10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466743

    UniProtKB/Swiss-Prot: M3K10_HUMAN, Q02779
    Tissue specificity: Expressed in brain and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP3K10: 
              Huntington's Disease in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MAP3K10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAP3K10
    QuantiTect SYBR Green Assays in human, mouse, rat MAP3K10
    QuantiFast Probe-based Assays in human, mouse, rat MAP3K10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MAP3K10 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map3k101 , 5 mitogen-activated protein kinase kinase kinase 101, 5 87.54(n)1
    92.46(a)1
      7 (15.95 cM)5
    2698811  NM_001081292.11  NP_001074761.11 
     276563755 
    lizard
    (Anolis carolinensis)
    Reptilia MAP3K106
    mitogen-activated protein kinase kinase kinase 10
    67(a)
    1 ↔ 1
    LGf(2370844-2386526)
    African clawed frog
    (Xenopus laevis)
    Amphibia mlk22 mixed lineage kinase 2 74.11(n)    AF510499.1 
    zebrafish
    (Danio rerio)
    Actinopterygii map3k101 mitogen-activated protein kinase kinase kinase 10 66.59(n)
    68.27(a)
      560932  XM_684332.5  XP_689424.4 
    worm
    (Caenorhabditis elegans)
    Secernentea K11D12.10b3   -- 31(a)   V(5056593-5064590)   --


    ENSEMBL Gene Tree for MAP3K10 (if available)
    TreeFam Gene Tree for MAP3K10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP3K10 gene
    FPGT-TNNI3K2  MAP3K122  MAP3K112  KIAA18042  RAF12  KSR22  KSR12  MOS2  
    BRAF2  MAP3K92  ARAF2  MAP3K72  TNNI3K2  ZAK2  MAP3K132  ILK2  
    15 SIMAP similar genes for MAP3K10 using alignment to 4 protein entries:     M3K10_HUMAN (see all proteins):
    MAP3K11    BRAF    MAP3K13    FPGT-TNNI3K    MAP3K9    EPHA10
    FGFR1    MLK4    MAP3K12    MST094    FLT1    tec
    pk    LTK    FGR

    MAP3K10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP3K10 (see all 583)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0407024
    A metastatic melanoma sample4--see VAR_0407022 G E mis40--------
    rs116715541,2
    C,H--40695707(+) TTTAGT/AGCACC 1 -- us2k1 tfbs34Minor allele frequency- A:0.00NS EA 418
    rs1487430031,2
    --40695850(+) GCCAGA/GAGACC 1 -- us2k10--------
    rs1437407011,2
    --40695890(+) CAATTC/TCCCAA 1 -- us2k10--------
    rs1467747361,2
    --40695895(+) CCCCAA/GGGACC 1 -- us2k10--------
    rs3395241,2
    C,A--40696120(+) GTTTGG/TTTTTT 1 -- us2k1 tfbs37Minor allele frequency- T:0.08NA WA CSA 13
    rs353704771,2
    C,F--40696130(+) TGTTG-/GTTTTTGTTG/
    T
    /TTTTTTGTTGT
    TTTTT
    1 -- us2k12NA 4
    rs2017092171,2
    --40696138(+) TTTTT-/GTTGTT 1 -- us2k10--------
    rs1116402761,2
    C--40696320(+) TAGATC/TACAGG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1810769191,2
    --40696344(+) GCCCGA/GCTAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAP3K10 (40697651 - 40721482 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MAP3K10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911699CNV Loss21882294
    dgv3865n71CNV Loss21882294
    dgv3866n71CNV Loss21882294
    nsv9728CNV Loss18304495
    nsv9727CNV Gain18304495
    nsv911697CNV Gain21882294
    dgv1083e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP3K10
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP3K10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600137    OMIM disorders: --

    9 diseases for MAP3K10:    
    About MalaCards
    alexander disease    differentiating neuroblastoma    neuroblastoma    huntington's disease
    tonsillitis    parkinson's disease    neuronitis    pancreatic cancer
    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for MAP3K10:
    Differentiating neuroblastoma

    MAP3K10 for disorders           About GeneDecksing


    Export disorders for MAP3K10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP3K10 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with MAP3K10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain. (PubMed id 7731697)1, 2, 3, 9 Katoh M.... Terada M. (Oncogene 1995)
    2. Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2. (PubMed id 8536694)1, 2, 3, 9 Dorow D.S.... Simpson R.J. (Eur. J. Biochem. 1995)
    3. Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains. (PubMed id 8477742)1, 2 Dorow D.S.... de Kretser T. (Eur. J. Biochem. 1993)
    4. Activated JNK phosphorylates the c-terminal domain of MLK2 that is required for MLK2-induced apoptosis. (PubMed id 11278395)1, 9 Phelan D.R....Dorow D.S. (J. Biol. Chem. 2001)
    5. Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease. (PubMed id 19332348)1, 9 Nagao M. and Hayashi H. (J. Neurol. Sci. 2009)
    6. Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin. (PubMed id 10801775)1, 9 Liu Y.F....Marshall J. (J. Biol. Chem. 2000)
    7. Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release. (PubMed id 17584736)1, 9 Zhong J. and Kyriakis J.M. (J. Biol. Chem. 2007)
    8. Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins. (PubMed id 9629920)1, 9 Rasmussen R.K....Dorow D.S. (Electrophoresis 1998)
    9. Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways. (PubMed id 19801649)1, 9 Pedraza N....Gallego C. (J. Biol. Chem. 2009)
    10. Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho. (PubMed id 15753034)1, 9 Jaffe A.B....Schmidt A. (Curr. Biol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4294 HGNC: 6849 AceView: MAP3K10 Ensembl:ENSG00000130758 euGenes: HUgn4294
    ECgene: MAP3K10 H-InvDB: MAP3K10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAP3K10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP3K10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAP3K10 gene:
    Search GeneIP for patents involving MAP3K10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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