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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP3K10 Gene

protein-coding   GIFtS: 65
GCID: GC19P040697

mitogen-activated protein kinase kinase kinase 10


(Previous symbol: MLK2)
 Explore 9 diseases affiliated with
MAP3K10 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAP3K10    

Aliases
for MAP3K10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 101 2     Protein Kinase MST2 3
MLK21 2 3 5     EC 2.7.11.253 8
MST1 2 3 5     MKN28 Derived Nonreceptor_type Serine/Threonine Kinase2
MEKK101 2     MKN28 Kinase2
Mixed Lineage Kinase 22 3     EC 2.7.118

External Ids:    HGNC: 68491   Entrez Gene: 42942   Ensembl: ENSG000001307587   OMIM: 6001375   UniProtKB: Q027793   

Export aliases for MAP3K10 gene to outside databases

Previous GC identifers: GC19P041337 GC19P041089 GC19P045373 GC19P045389 GC19P037132


Summaries
for MAP3K10 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAP3K10:
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to
activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This
kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor
(NGF) induced neuronal apoptosis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: M3K10_HUMAN, Q02779
Function: Activates the JUN N-terminal pathway (By similarity)

Gene Wiki entry for MAP3K10


Genomic Views
for MAP3K10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP3K10 gene promoter:
         Spz1   AML1a   MIF-1   CUTL1   C/EBPalpha   CHOP-10   AP-2beta   ZIC2/Zic2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAP3K10 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP3K10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

MAP3K10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K10 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P040697:  view genomic region     (about GC identifiers)

Start:
 40,697,651 bp from pter      End:
 40,721,482 bp from pter
Size:
 23,832 bases      Orientation:
 plus strand

Proteins
for MAP3K10 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: M3K10_HUMAN, Q02779 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 10  
Size: 954 amino acids; 103694 Da
Cofactor: Magnesium (By similarity)
Subunit: Homodimer (By similarity)
1 PDB 3D structure from and Proteopedia for MAP3K10:
2RF0 (3D)    
Secondary accessions: Q12761 Q14871

Explore the universe of human proteins at neXtProt for MAP3K10: NX_Q02779

Post-translational modifications:

  • Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation (By
    • similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q02779

    • 4/13 DME Specific Peptides for MAP3K10 (Q02779) (see all 13)
     FPRLPDP  SGDEGWW  WMAPEVI  ELTLRRG 

    MAP3K10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002437.2  
    ENSEMBL proteins: 
     ENSP00000253055  

    Human Recombinant Protein Products: 
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    Novus Biologicals MAP3K10 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MAP3K10

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA18455992


    MAP3K10 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MAP3K10

    Protein Domains /
    Families
    for MAP3K10 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAP3K10 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR016231 MAPKKK9/10/11
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q02779

    ProtoNet protein and cluster: Q02779

    1 Blocks protein family: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: M3K10_HUMAN, Q02779
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH3 domain


    Function
    for MAP3K10 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: M3K10_HUMAN, Q02779
    Function: Activates the JUN N-terminal pathway (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent
    activation (By similarity)

         Genatlas biochemistry entry for MAP3K10:
    mitogen activated protein (MAP/ERK) kinase kinase kinase 10

    Enzyme Numbers (IUBMB): EC 2.7.11.251 2 EC 2.7.112

    miRNA
    Products:            		miRTarBase miRNAs that target MAP3K10:
    hsa-mir-181b (MIRT005545)

    OriGene 3'-UTR Clone: MAP3K10
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP3K10
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP3K10 (see all 14):
    hsa-miR-647 hsa-miR-146b-3p hsa-miR-125a-5p hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-125b hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmid: MAP3K10 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP3K10 (see all 4)
    OriGene shRNA RFP: MAP3K10
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP3K10

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAP3K10

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K10 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K10 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MAP3K10 (NM_002446)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP3K10 

    Cell Line
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    Search LifeMap BioReagents cell lines for MAP3K10

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K10

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity ISS--
    GO:0004672protein kinase activity TAS10801775
    GO:0004674protein serine/threonine kinase activity IDA19801649
    GO:0004706JUN kinase kinase kinase activity ISS--
    GO:0005524ATP binding IEA--


    MAP3K10 for ontologies           About GeneDecksing


    10 GenomeRNAi human phenotypes for MAP3K10:
     Cell division defect  Decreased TP53 protein express  Decreased substrate adherent c  Increased S DNA content 
     Increased cell death HMECs cel  Increased cell death in breast  Increased colony dispersion (i  Increased number of cells in m 
     Increased number of mitotic ce  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Map3k10tm1Dsd for MAP3K10
         10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Map3k10):
     digestive/alimentary  embryogenesis  homeostasis/metabolism  immune system  mortality/aging 
     muscle  nervous system  normal  renal/urinary system  reproductive system 

    MAP3K10 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAP3K10 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development HGF signaling pathway
    		Development_EGFR signaling via small GTPases0.44
    		Development_EGFR signaling via PIP30.26
    		Development EGFR signaling via small GTPases0.44
    		Development EGFR signaling via PIP30.26
    2Development EGFR signaling pathway
    		Development EGFR signaling pathway1.00
    		EGF Pathway0.39
    		Development_EGFR signaling pathway0.87
    3Signal transduction_JNK pathway
    		Signal transduction_JNK pathway1.00
    		Signal transduction JNK pathway0.98
    4Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    5TGF-Beta Pathway
    		MAPK Family Pathway0.60
    		JNK Pathway0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 EMD Millipore Pathways for MAP3K10
        Development EGFR signaling via PIP3
    Development EGFR signaling via small GTPases
    Signal transduction JNK pathway
    Development EGFR signaling pathway

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP3K10 (see all 11)
        MAPK Signaling
    STAT3 Pathway
    JNK Pathway
    TNFR2 Pathway
    NFAT and Cardiac Hypertrophy

    4 GeneGo (Thomson Reuters) Pathways for MAP3K10
        Development EGFR signaling via PIP3
    Development EGFR signaling pathway
    Signal transduction JNK pathway
    Development EGFR signaling via small GTPases

    2 BioSystems Pathways for MAP3K10 
        Insulin Signaling
    p38 MAPK signaling pathway



    MAP3K10 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP3K10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for MAP3K10 (Q027793 ENSP000002530554) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL2P426843, ENSP000003565954I2D: score=3 STRING: ENSP00000356595
    CLTCQ006103, ENSP000002691224I2D: score=3 STRING: ENSP00000269122
    CNKSR1Q969H43, ENSP000003546094I2D: score=3 STRING: ENSP00000354609
    HTTP428583, ENSP000003471844I2D: score=3 STRING: ENSP00000347184
    KIAA1804Q5TCX83, ENSP000003555834I2D: score=3 STRING: ENSP00000355583
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006917induction of apoptosis TAS10801775
    GO:0007165signal transduction TAS10801775
    GO:0007224smoothened signaling pathway IMP18455992
    GO:0007254JNK cascade TAS10801775


    MAP3K10 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAP3K10 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP3K10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP3K10

    3 HMDB Compounds for MAP3K10    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    4 Novoseek chemical compound relationships for MAP3K10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 56.3 10 7731697 (3), 15069087 (1), 11416147 (1), 8536694 (1) (see all 6)
    threonine 50.8 4 7731697 (3), 19801649 (1)
    proline 42 3 7731697 (2), 11590155 (1)
    serine 37.9 4 7731697 (3), 19801649 (1)

    Search CenterWatch for drugs/clinical trials and news about MAP3K10 / M3K10 

    Transcripts
    for MAP3K10 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAP3K10 gene: 
    NM_002446.3  

    Unigene Cluster for MAP3K10:

    Mitogen-activated protein kinase kinase kinase 10
    Hs.466743  [show with all ESTs]
    Unigene Representative Sequence: X90846
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000253055(uc002ona.3)

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP3K10 (see all 14):
    hsa-miR-647 hsa-miR-146b-3p hsa-miR-125a-5p hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-125b hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmid: MAP3K10 3' UTR sequence
    Inhib. RNA
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP3K10
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    Additional cDNA sequence: 

    X90846.1 Z48615.1 

    6 DOTS entries:

    DT.408555  DT.99988514  DT.121435342  DT.108565  DT.108566  DT.40110995 

    24/58 AceView cDNA sequences (see all 58):

    BX103677 BM784975 BU633407 CR605472 BM764493 BM783445 BU930875 NM_002446 
    AL539199 AI831487 AI814612 X90846 BF514325 AW452931 AI879161 AI991621 
    BG106120 BF594729 BQ636998 AI878963 BM547820 CK903601 BI962978 AA630673 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K10    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9
    SP1:                                                                                            -         
    SP2:                                                        -     -                                       
    SP3:                                -     -     -           -     -                                       
    SP4:                                      -     -                                                         
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for MAP3K10

    Expression
    for MAP3K10 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP3K10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGGATTTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MAP3K10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP3K10

    SOURCE GeneReport for Unigene cluster: Hs.466743

    UniProtKB/Swiss-Prot: M3K10_HUMAN, Q02779
    Tissue specificity: Expressed in brain and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAP3K10: 
              Huntington's Disease in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP3K10
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K10

    Orthologs
    for MAP3K10 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAP3K10 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia MAP3K106
    		 --
    		 67(a)
    		 1 ↔ 1
    		 LGf(2371431-2383730)
    African clawed frog
    (Xenopus laevis)    		 Amphibia mlk22 mixed lineage kinase 2 74.11(n)    AF510499.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5609321 similar to mixed lineage kinase 2 67(n)
    68.83(a)    		   560932  XM_684332.4  XP_689424.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta slpr3 JNK cascade protein kinase 50(a)   7D17   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G247156
    AT3G469206
    (see all 7)    		 octicosapeptide/Phox/Bem1p domain-containing prote...
    octicosapeptide/Phox/Bem1p domain-containing prote...
    (see all 7)    		 9(a)
    9(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 3(9025849-9029948)
    3(17280430-17284857)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 5)    		 protein kinase domain containing protein, expresse...
    protein kinase domain containing protein, expresse...
    (see all 5)    		 8(a)
    8(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 6(4007140-4012540)
    7(14722116-14730584)


    ENSEMBL Gene Tree for MAP3K10 (if available)
    TreeFam Gene Tree for MAP3K10 (if available) 

    Paralogs
    for MAP3K10 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP3K10 gene
    MAP3K112  MAP3K122  KIAA18042  RAF12  KSR22  KSR12  MOS2  BRAF2  
    MAP3K92  ARAF2  MAP3K72  MAP3K7CL2  TNNI3K2  ZAK2  MAP3K132  ILK2  
    5 SIMAP similar genes for MAP3K10 using alignment to 4 protein entries:     M3K10_HUMAN (see all proteins):
    MAP3K9    MLK4    MAP3K12    pk    MAP3K11

    MAP3K10 for paralogs           About GeneDecksing



    Genomic Variants
    for MAP3K10 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/441 NCBI SNPs in MAP3K10 are shown (see all 441)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs116715541,2
    		C,H--40695707(+) TTTAGT/AGCACC 1 -- us2k1 tfbs34Minor allele frequency- A:0.00NS EA 418
    rs1487430031,2
    		--40695850(+) GCCAGA/GAGACC 1 -- us2k10--------
    rs1437407011,2
    		--40695890(+) CAATTC/TCCCAA 1 -- us2k10--------
    rs1467747361,2
    		--40695895(+) CCCCAA/GGGACC 1 -- us2k10--------
    rs3395241,2
    		C,A,--40696120(+) GTTTGG/TTTTTT 1 -- us2k1 tfbs37Minor allele frequency- T:0.08NA WA CSA 13
    rs711715471,2
    		C--40696130(+) TGTTG-/TTTTTT 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs2017092171,2
    		--40696138(+) TTTTT-/GTTGTT 1 -- us2k10--------
    rs1810769191,2
    		--40696344(+) GCCCGA/GCTAAT 1 -- us2k10--------
    rs1848793861,2
    		--40696380(+) AGACGA/GGGGTT 1 -- us2k10--------
    rs37609171,2
    		C,--40696478(-) GGCGCA/GGTGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAP3K10 (40697651 - 40721482 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for MAP3K10
         2 CNVs: 4080 30907
         1 Indel: 33670

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for MAP3K10 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAP3K10 for disorders           About GeneDecksing

    OMIM gene information: 600137    OMIM disorders: --

    9 diseases for MAP3K10:    About MalaCards
    alexander disease    differentiating neuroblastoma    neuronitis    huntington's disease
    parkinson's disease    breast carcinoma    neuroblastoma    immunodeficiency
    carcinoma

    1 disease from the University of Copenhagen DISEASES database for MAP3K10:
    Differentiating neuroblastoma

    Export disorders for MAP3K10 gene to outside databases

    Publications
    for MAP3K10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP3K10 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with MAP3K10)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain. (PubMed id 7731697)1, 2, 3, 9 Katoh M.... Terada M. (1995)
    2. Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2. (PubMed id 8536694)1, 2, 3, 9 Dorow D.S.... Simpson R.J. (1995)
    3. Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains. (PubMed id 8477742)1, 2 Dorow D.S.... de Kretser T. (1993)
    4. Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease. (PubMed id 19332348)1, 9 Nagao M. and Hayashi H. (2009)
    5. Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin. (PubMed id 10801775)1, 9 Liu Y.F....Marshall J. (2000)
    6. Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release. (PubMed id 17584736)1, 9 Zhong J. and Kyriakis J.M. (2007)
    7. Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins. (PubMed id 9629920)1, 9 Rasmussen R.K....Dorow D.S. (1998)
    8. Mixed lineage kinase phosphorylates transcription fac tor E47 and inhibits TrkB expression to link neuronal death and survival pathwa ys. (PubMed id 19801649)1, 9 Pedraza N....Gallego C. (2009)
    9. Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho. (PubMed id 15753034)1, 9 Jaffe A.B....Schmidt A. (2005)
    10. The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. (PubMed id 11416147)1, 9 Xu Z....Greene L.A. (2001)

    External Searches for MAP3K10 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAP3K10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4294 HGNC: 6849 AceView: MAP3K10 Ensembl:ENSG00000130758 euGenes: HUgn4294
    ECgene: MAP3K10 H-InvDB: MAP3K10

    Other Databases showing MAP3K10 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAP3K10 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP3K10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP3K10 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MAP3K10 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAP3K10 gene:
    Search GeneIP for patents involving MAP3K10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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