Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MAP3K1 Gene

protein-coding GIFtS: 65
GCID: GC05P056110

mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin...

(Previous name: mitogen-activated protein kinase kinase kinase 1 )
(Previous symbol: MEKK1)

Explore 38 diseases affiliated with
MAP3K1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 1, E3 Ubiquitin Protein Ligase¹ ²		MEK Kinase 1² ³
MEKK¹ ² ³ ⁵		MEKK 1² ³
MEKK1¹ ² ³ ⁵		SRXY6²
MAPKKK1¹ ² ³		MAP/ERK Kinase Kinase 1²
Mitogen-Activated Protein Kinase Kinase Kinase 1¹ ²		EC 2.7.11.25³
MAPK/ERK Kinase Kinase 1² ³

External Ids:	HGNC: 6848¹	Entrez Gene: 4214²	Ensembl: ENSG00000095015⁷	OMIM: 600982⁵	UniProtKB: Q13233³

Export aliases for MAP3K1 gene to outside databases

Previous GC identifers: GC05P056276 GC05P057669 GC05P056081 GC05P056126 GC05P056146 GC05P053082

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAP3K1:

The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades,

including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by

autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase

activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase

domain in its C-terminus. (provided by RefSeq, Mar 2012)

UniProtKB/Swiss-Prot: M3K1_HUMAN, Q13233

Function: Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by

phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway

Gene Wiki entry for MAP3K1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006713.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MAP3K1 gene promoter:
Sp1 p53 AP-1 ATF-2 STAT3 c-Jun C/EBPalpha
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for MAP3K1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2 Ensembl cytogenetic band: 5q11.2 HGNC cytogenetic band: 5q11.2

MAP3K1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K1 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P056110: view genomic region (about GC identifiers)

Start:	56,110,900 bp from pter	End:	56,191,979 bp from pter
Size:	81,080 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: M3K1_HUMAN, Q13233 (See protein sequence)

Recommended Name: Mitogen-activated protein kinase kinase kinase 1

Size: 1512 amino acids; 164470 Da

Cofactor: Magnesium

Subunit: Binds both upstream activators and downstream substrates in multimolecular complexes through its N-terminus.

Oligomerizes after binding MAP4K2 or TRAF2. Interacts with AXIN1. Interacts (via the kinase catalytic domain) with

STK38

Explore the universe of human proteins at neXtProt for MAP3K1: NX_Q13233

Post-translational modifications:

Autophosphorylated (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13233

MAP3K1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005912.1

ENSEMBL proteins:

ENSP00000382423

Reactome Protein details: Q13233
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for MAP3K1
	GenScript Custom Purified and Recombinant Proteins Services for MAP3K1
	Novus Biologicals MAP3K1 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MAP3K1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--
GO:0005856	cytoskeleton	--	--

MAP3K1 for ontologies About GeneDecksing

MAP3K1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP3K1
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for MAP3K1
	GenScript Custom Superior Antibodies Services for MAP3K1
	Novus Biologicals MAP3K1 Antibodies
	Search for Antibodies for MAP3K1 at Abcam
	Uscn Antibodies for MAP3K1
	ThermoFisher Antibodies for MAP3K1

Assay Products for MAP3K1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MAP3K1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MAP3K1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MAP3K1 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR017441 Protein_kinase_ATP_BS

IPR001841 Znf_RING

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

Graphical View of Domain Structure for InterPro Entry Q13233

ProtoNet protein and cluster: Q13233

2 Blocks protein families:

IPB001841 Zn-finger

IPB007527 SWIM Zn-finger

UniProtKB/Swiss-Prot: M3K1_HUMAN, Q13233

Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase

subfamily

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 RING-type zinc finger

Similarity: Contains 1 SWIM-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: M3K1_HUMAN, Q13233

Function: Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by

phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Activated by autophosphorylation on Thr-1400 and Thr-1412 following oligomerization

Genatlas biochemistry entry for MAP3K1:

mitogen-activated protein (MAP/ERK) kinase kinase kinase 1,stress activated protein kinase,exercizing an antiapoptotic

function as activator of C-Jun amino-terminal kinase (JNK) in response to changes in the microtubule cytoskeleton and

extra signal-regulated protein kinase (ERK),also involved in apoptosis as caspase-3 substrate and in the induction of

apoptosis by genotoxins but not by microtubule altering drugs. Stimulating MADH2 mediated transcriptional activation

in endothelial cells

Enzyme Number (IUBMB): EC 2.7.11.25¹

miRNA Products:		miRTarBase miRNAs that target MAP3K1: hsa-mir-192 (MIRT004142)

		OriGene 3'-UTR Clone: MAP3K1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP3K1
		8/121 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP3K1 (see all 121):
		hsa-miR-100* hsa-miR-640 hsa-miR-3607-3p hsa-miR-520e hsa-miR-411 hsa-miR-106a hsa-miR-938 hsa-miR-30d

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP3K1 (see all 7) OriGene shRNA RFP: MAP3K1 OriGene siRNA: MAP3K1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP3K1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MAP3K1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K1 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MAP3K1 (NM_005921)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP3K1
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAP3K1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MAP3K1
		Search LifeMap BioReagents cell lines for MAP3K1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K1

Gene Ontology (GO): 5/14 molecular function terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	TAS	--
GO:0004706	JUN kinase kinase kinase activity	--	--
GO:0004709	MAP kinase kinase kinase activity	NAS	9808624
GO:0004842	ubiquitin-protein ligase activity	--	--
GO:0005515	protein binding	IPI	11784851

MAP3K1 for ontologies About GeneDecksing

12 GenomeRNAi human phenotypes for MAP3K1:

Decreased NANOG protein expres	Decreased OCT4 protein express	Decreased POU5F1-GFP protein e	Decreased substrate adherent c
Decreased telomerase activity	Gemcitabine induced cell-death	Increased apoptosis	Increased colony dispersion (i
Synthetic lethal with Ras	Synthetic lethal with gemcitab	Upregulation of NF-kappaB path	Upregulation of Wnt/beta-caten

Animal Models:
Mouse knock-out Map3k1^tm1Glj for MAP3K1
13 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Map3k1):

behavior/neurological	cardiovascular system	cellular	homeostasis/metabolism	immune system
integument	mortality/aging	muscle	other	pigmentation
skeleton	tumorigenesis	vision/eye

MAP3K1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/60 super-pathways (see all 60) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TRAF6 Mediated Induction of proinflammatory cytokines

8/14 pathways (see all 14)
Toll Like Receptor 10 (TLR10) Cascade	0.86	Toll Like Receptor TLR6:TLR2 Cascade	0.78
Toll Like Receptor 5 (TLR5) Cascade	0.86	Toll Like Receptor TLR1:TLR2 Cascade	0.78
MyD88 cascade initiated on plasma membrane	0.86	Toll Like Receptor 2 (TLR2) Cascade	0.78
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	0.85	MyD88:Mal cascade initiated on plasma membrane	0.78

Development HGF signaling pathway

Development HGF signaling pathway	1.00	Development PDGF signaling via MAPK cascades	0.41
Development_HGF signaling pathway	0.78	Development_PDGF signaling via MAPK cascades	0.41
Development_Neurotrophin family signaling	0.45	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)	0.23
Development Neurotrophin family signaling	0.45	Neurotrophin signaling pathway	0.20

G-protein signaling_Ras family GTPases in kinase cascades (scheme)

G-protein signaling Ras family GTPases in kinase cascades (scheme)	1.00	Immune response Oncostatin M signaling via MAPK in human cells	0.39
G-protein signaling_Ras family GTPases in kinase cascades (scheme)	1.00	Immune response_Role of integrins in NK cells cytotoxicity	0.28
MAPK Cascade	0.44	Immune response Role of integrins in NK cells cytotoxicity	0.28
Immune response_Oncostatin M signaling via MAPK in human cells	0.39

Development FGFR signaling pathway

	Development FGFR signaling pathway	1.00			Development_Flt3 signaling	0.45
	Development_FGFR signaling pathway	0.98			Development Flt3 signaling	0.45

G-protein signaling_Regulation of p38 and JNK signaling mediated by G-proteins

	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins	1.00			G-protein signaling_G-Protein alpha-12 signaling pathway	0.40
	G-protein signaling_Regulation of p38 and JNK signaling mediated by G-proteins	1.00			G-protein signaling G-Protein alpha-12 signaling pathway	0.40

Pathway sources
See GeneCards unified pathways
Show all pathways

5/30 EMD Millipore Pathways for MAP3K1 (see all 30)

	Cytoskeleton remodeling FAK signaling
	Apoptosis and survival FAS signaling cascades
	Immune response MIF in innate immunity response
	G-protein signaling G-Protein alpha-12 signaling pathway
	Immune response CCR3 signaling in eosinophils

5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP3K1 (see all 9)

	Interferon Pathway
	CRHR Pathway
	TNFR2 Pathway
	NFAT and Cardiac Hypertrophy
	PACAP Signaling

5/32 GeneGo (Thomson Reuters) Pathways for MAP3K1 (see all 32)

	Development A2A receptor signaling
	Immune response MIF in innate immunity response
	Transcription P53 signaling pathway
	Development Endothelin-1/EDNRA signaling
	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins

5/28 BioSystems Pathways for MAP3K1 (see all 28)

	FAS pathway and Stress induction of HSP regulation
	DNA damage response (only ATM dependent)
	p38 MAPK Signaling Pathway
	EGFR1 Signaling Pathway
	Apoptosis

5/18 Reactome Pathways for MAP3K1 (see all 18)

	Toll Like Receptor 2 (TLR2) Cascade
	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
	Toll Like Receptor TLR6:TLR2 Cascade
	Toll-Like Receptors Cascades
	Toll Like Receptor 7/8 (TLR7/8) Cascade

2 PharmGKB Pathways for MAP3K1

	EGFR Inhibitor Pathway, Pharmacodynamics
	Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

5 Kegg Pathways (Kegg details for MAP3K1):

	MAPK signaling pathway
	Ubiquitin mediated proteolysis
	RIG-I-like receptor signaling pathway
	Neurotrophin signaling pathway
	GnRH signaling pathway

MAP3K1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MAP3K1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/224 Interacting proteins for MAP3K1 (Q13233^{1, 2, 3} ENSP00000382423⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 224)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805²^,³	MINT-48337 I2D: score=2
HIST1H4B	P62805²^,³	MINT-48337 I2D: score=2
HIST1H4C	P62805²^,³	MINT-48337 I2D: score=2
HIST1H4D	P62805²^,³	MINT-48337 I2D: score=2
HIST1H4E	P62805²^,³	MINT-48337 I2D: score=2

About this table

Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000165	MAPK cascade	--	--
GO:0000186	activation of MAPKK activity	NAS	9808624
GO:0000209	protein polyubiquitination	--	--
GO:0002224	toll-like receptor signaling pathway	TAS	--
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	TAS	--

MAP3K1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MAP3K1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MAP3K1

3 HMDB Compounds for MAP3K1 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

10/42 Novoseek chemical compound relationships for MAP3K1 gene (see all 42) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
anisomycin	63.4	3	16434970 (1), 7935449 (1), 10506143 (1)
sp 600125	58.4	6	16452190 (3), 17078934 (1), 15001534 (1), 16771680 (1)
pd 98,059	56.2	7	10601300 (1), 10753939 (1), 11160424 (1), 14737074 (1) (see all 7)
sb 203580	52.7	5	12506144 (1), 11315998 (1), 12472895 (1), 11062239 (1)
threonine	51.7	4	9405407 (1), 9820741 (1), 11337492 (1), 18308848 (1)
curcumin	48.6	3	9674701 (1), 10942386 (1), 9918209 (1)
rottlerin	48.1	1	18160487 (1)
12-o-tetradecanoylphorbol 13-acetate	41.9	11	9858570 (3), 11042219 (2), 8073291 (2), 9733728 (1) (see all 5)
geranylgeraniol	41.1	1	11086177 (1)
serine	39.2	4	9405407 (1), 11278353 (1), 9820741 (1), 11337492 (1)

Search CenterWatch for drugs/clinical trials and news about MAP3K1 / M3K1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MAP3K1 gene:

NM_005921.1

Unigene Cluster for MAP3K1:

Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase

Hs.653654 [show with all ESTs]

Unigene Representative Sequence: NM_005921

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000399503(uc003jqw.4) ENST00000469188

miRNA Products:		OriGene 3'-UTR Clone: MAP3K1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP3K1
		8/121 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP3K1 (see all 121):
		hsa-miR-100* hsa-miR-640 hsa-miR-3607-3p hsa-miR-520e hsa-miR-411 hsa-miR-106a hsa-miR-938 hsa-miR-30d

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP3K1 (see all 7) OriGene shRNA RFP: MAP3K1 OriGene siRNA: MAP3K1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP3K1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K1 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MAP3K1 (NM_005921)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP3K1
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAP3K1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP3K1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MAP3K1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP3K1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP3K1

Additional cDNA sequence:

AF042838.1 AK307828.1 BX537527.1 U56433.1

4 DOTS entries:

DT.100642426 DT.112213 DT.97760286 DT.40131820

24/82 AceView cDNA sequences (see all 82):

AL135609 BE645815 AA834992 AU132367 AW511515 BQ024720 BE349320 AA464694

AI804275 AI074721 AI125918 AW572284 AW235188 BE041542 AA864536 BU172741

BV173870 BM148300 AL133917 AL042445 BX498716 AI684800 AI760113 AI625811

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19	^	20a	·	20b
SP1:
SP2:

ECgene alternative splicing isoforms for MAP3K1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MAP3K1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCACCACAT

About this image

MAP3K1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MAP3K1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAP3K1

SOURCE GeneReport for Unigene cluster: Hs.653654

SABiosciences Expression via Pathway-Focused PCR Arrays including MAP3K1 (see all 8):

Antiviral Response in human mouse rat

Toll-Like Receptor Signaling Pathway in human mouse rat

Hypoxia Signaling Pathway in human mouse rat

Ubiquitin Ligases in human mouse rat

NFKB Signaling Pathway in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP3K1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MAP3K1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP3K1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP3K1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAP3K1 gene from 6/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MAP3K1¹	mitogen-activated protein kinase kinase kinase 1	80.48(n) 84.77(a)		427144 XM_424734.3 XP_424734.3
lizard (Anolis carolinensis)	Reptilia	MAP3K1⁶	--	85(a)	1 ↔ 1	2(1891695-1921673)
African clawed frog (Xenopus laevis)	Amphibia	Xl.12302²	Xenopus laevis transcribed sequence with moderate similarity more	77.6(n)		BU904431.1
zebrafish (Danio rerio)	Actinopterygii	LOC100334486¹	mitogen-activated protein kinase kinase kinase 1-like	65.79(n) 71.31(a)		100334486 XM_002663485.2 XP_002663531.2
thale cress (Arabidopsis thaliana)	eudicotyledons	MAPKKK18⁶ MAPKKK19⁶ (see all 26)	mitogen-activated protein kinase kinase kinase 19 (see all 26)	24(a) 24(a) (see all 26)	possible ortholog possible ortholog (see all 26)	1(1469610-1470881) 5(26772726-26773760)
rice (Oryza sativa)	Liliopsida	-- -- (see all 11)	STE_MEKK_ste11_MAP3K.11 - STE kinases include homo... STE_MEKK_ste11_MAP3K.8 - STE kinases include homol... (see all 11)	32(a) 21(a) (see all 11)	possible ortholog possible ortholog (see all 11)	2(32455259-32456963) 2(12893454-12895429)

ENSEMBL Gene Tree for MAP3K1 (if available)
TreeFam Gene Tree for MAP3K1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MAP3K1 gene

MAP3K3² MAP3K5² MAP3K15² MAP3K19² MAP3K2² MAP3K8² MAP3K6²

12 SIMAP similar genes for MAP3K1 using alignment to 2 protein entries: M3K1_HUMAN (see all proteins):

MAP3K2 DKFZp564L2416 MST094 NEK6 STK11 MAP2K5

MYO3A CDK4 NUAK1 PAK4 PRKAA1 AURKC

MAP3K1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12515369^1,2	H	--	53081052(+)	`ATTCAG/AAGCCT`	1	--	us2k¹		4		NS EA	416
rs80272431^1,2	C,	--	53081371(+)	`AGGAAG/ATGAGA`	1	--	us2k¹		2		CSA WA	119
rs12515972^1,2	H	--	53081385(+)	`TTGTAG/ACTAGT`	1	--	us2k¹		4		NS EA	420
rs73133580^1,2	C,F,	--	53081980(+)	`TATGTG/TAAGAC`	1	--	us2k¹		3		WA	122
rs73133582^1,2	C,	--	53082140(+)	`AGGAAG/TAAATA`	1	--	us2k¹		1		WA	2
rs74457017^1,2	C,	--	53082300(+)	`GAGTGG/AGGACA`	1	--	us2k¹		1		WA	2
rs79525051^1,2	C,F,	--	53082337(+)	`CTGCAG/TGGAAG`	1	--	us2k¹		1		WA	118
rs80096098^1,2	C,	--	53082348(+)	`AAGGAA/CGTGCG`	1	--	us2k¹		0	--	--	--	--
rs114840741^1,2	C,F,	--	53082962(+)	`AGCTCC/TGCGGT`	1	--	ut5¹		1		WA	118
rs75307949^1,2	C,F,	--	53084648(+)	`GAACTG/ACACTG`	1	--	int¹		1		EA	120

HapMap Linkage Disequilibrium report for MAP3K1 (56110900 - 56191979 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MAP3K1
1 CNV: 64209
1 Indel: 46900
Human Gene Mutation Database (HGMD): MAP3K1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP3K1

DNA2.0 Custom Variant and Variant Library Synthesis for MAP3K1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MAP3K1 for disorders About GeneDecksing

OMIM gene information: 600982 OMIM disorders: --

UniProtKB/Swiss-Prot: M3K1_HUMAN, Q13233

Defects in MAP3K1 are the cause of 46,XY sex reversal type 6 (SRXY6) [MIM:613762]. SRXY6 is a disorder of sex

development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females

20/38 diseases for MAP3K1 (see all 38): About MalaCards

xy sex reversal sex reversal familial adenomatous polyposis disorders of sex development

polycystic kidney disease myeloid leukemia breast cancer susceptibility polyposis

breast cancer kaposi's sarcoma kidney disease familial breast cancer

squamous cell carcinoma pheochromocytoma rheumatoid arthritis osteoarthritis

ovarian cancer pancreatic cancer crohn's disease prostate cancer

1 disease from the University of Copenhagen DISEASES database for MAP3K1:

Breast cancer

10/20 Novoseek disease relationships for MAP3K1 gene (see all 20) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	38.5	12	12584189 (2), 9395240 (1), 11784851 (1), 10805784 (1) (see all 10)
tumors	26	20	16568086 (3), 12584189 (2), 9395240 (1), 11784851 (1) (see all 12)
pancreatic cancer	14.3	12	12185592 (3), 15767210 (2), 19513748 (2), 12963995 (1)
cancer	13.6	5	15767210 (2), 15072767 (1), 16568086 (1), 12185592 (1)
leukemogenesis	8.13	1	16044153 (1)
myeloid leukemia	2.02	1	9858570 (1)
leukemia t-cell	1.98	1	10648602 (1)
cancer lung	0	1	14612408 (1)
myeloma	0	1	14737074 (1)
breast cancer	0	3	16568086 (1), 17681752 (1), 11509655 (1)

Human Genome Epidemiology (HuGE) Navigator: MAP3K1 (32 documents)

Export disorders for MAP3K1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MAP3K1 gene, integrated from 9 sources (see all 405):
(articles sorted by number of sources associating them with MAP3K1)

Utopia: connect your pdf to the dynamic
world of online information

Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5. (PubMed id 8597633)^{1, 2, 3} Vinik B.S.... Fiedorek F.T. Jr. (1995)
JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. (PubMed id 9808624)^{1, 2, 9} Xia Y.... Karin M. (1998)
SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling. (PubMed id 12223491)^{1, 2, 9} Rui H.L....Lin S.C. (2002)
Mutations in MAP3K1 cause 46,XY disorders of sex deve lopment and implicate a common signal transduction pathway in human testis dete rmination. (PubMed id 21129722)^{1, 2} Pearlman A....Ostrer H. (2010)
Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). (PubMed id 17906693)^{1, 2} Enomoto A....Miyagawa K. (2008)
Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways. (PubMed id 12456688)^{1, 9} Witowsky J.A. and Johnson G.L. (2003)
RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity. (PubMed id 14581471)^{1, 9} Gallagher E.D....Cobb M.H. (2004)
Depleting MEKK1 expression inhibits the ability of in vasion and migration of human pancreatic cancer cells. (PubMed id 19513748)^{1, 9} Su F....Chen X. (2009)
MAPK kinase kinase-1 is essential for cytokine-induced c-Jun NH2-terminal kinase and nuclear factor-kappaB activation in human pancreatic islet cells. (PubMed id 18420486)^{1, 9} Mokhtari D....Welsh N. (2008)
Glycogen synthase kinase 3 beta is a natural activator of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1). (PubMed id 12584189)^{1, 9} Kim J.W....Choi E.J. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4214	HGNC: 6848	AceView: MAP3K1	Ensembl:ENSG00000095015	euGenes: HUgn4214
ECgene: MAP3K1	Kegg: 4214	H-InvDB: MAP3K1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MAP3K1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MAP3K1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MAP3K1 gene:
Search GeneIP for patents involving MAP3K1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP3K1
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for MAP3K1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP3K1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP3K1
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for MAP3K1		OriGene 3'-UTR Clone for MAP3K1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP3K1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MAP3K1		OriGene Custom Protein Services for MAP3K1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAP3K1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP3K1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP3K1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP3K1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP3K1

	GenScript Custom Purified and Recombinant Proteins Services for MAP3K1		GenScript cDNA clones with any tag delivered in your preferred vector for MAP3K1
	GenScript Custom Assay Services for MAP3K1		GenScript Custom Superior Antibodies Services for MAP3K1
	GenScript Custom overexpressing Cell Line Services for MAP3K1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in MAP3K1 promoter
	Search Chromatin IP Primers for MAP3K1
	RT² qPCR Primer Assay in human, mouse, rat MAP3K1
	GNC Network for MAP3K1
	SABiosciences PCR Arrays including human, mouse, rat MAP3K1

Search Tocris compounds for MAP3K1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	MAP3K1 antibodies
	MAP3K1 proteins

	Search for Antibodies for MAP3K1 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for MAP3K1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

MAP3K1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for MAP3K1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K1

	Browse SwitchGear 3'UTR luciferase reporter plasmids for MAP3K1
	Browse SwitchGear Promoter luciferase reporter plasmids for MAP3K1

ThermoFisher Antibodies for MAP3K1

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAP3K1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MAP3K1 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

MAP3K1 Gene

mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin...

Aliases
for MAP3K1 gene

Summaries
for MAP3K1 gene

Genomic Views
for MAP3K1 gene

Proteins
for MAP3K1 gene

Protein Domains /
Families
for MAP3K1 gene

Function
for MAP3K1 gene

Pathways & Interactions
for MAP3K1 gene

Drugs & Compounds
for MAP3K1 gene

Transcripts
for MAP3K1 gene

Expression
for MAP3K1 gene

Orthologs
for MAP3K1 gene

Paralogs
for MAP3K1 gene

Genomic Variants
for MAP3K1 gene

Disorders / Diseases
for MAP3K1 gene

Publications
for MAP3K1 gene

External Searches for MAP3K1 gene

Genome Databases showing MAP3K1 gene

Other Databases showing MAP3K1 gene

Specialized Databases showing MAP3K1 gene

Intellectual Property
for MAP3K1 gene

Products
for MAP3K1 gene

View Random Gene

Myeloid Leukemia
Melanoma
Leukemia T-Cell
Ovarian Cancer
familial adenomatous polyposis
Osteoarthritis
immunodeficiency
Myeloid Leukemia Chronic
MYELOMA
Breast Cancer
prostate cancer
Tumors
Pheochromocytoma
Metastasis
Adenocarcinoma
leukemogenesis
Necrosis
Cancer
Pancreatic Cancer
Cancer Lung

Advanced Search

Export list of displayed genes

MAP3K1 Gene

mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin...

Aliasesfor MAP3K1 gene

Summariesfor MAP3K1 gene

Genomic Viewsfor MAP3K1 gene

Proteinsfor MAP3K1 gene

Protein Domains /Familiesfor MAP3K1 gene

Functionfor MAP3K1 gene

Pathways & Interactionsfor MAP3K1 gene

Drugs & Compoundsfor MAP3K1 gene

Transcriptsfor MAP3K1 gene

Expression for MAP3K1 gene

Orthologsfor MAP3K1 gene

Paralogsfor MAP3K1 gene

Genomic Variantsfor MAP3K1 gene

Disorders / Diseasesfor MAP3K1 gene

Publicationsfor MAP3K1 gene

External Searches for MAP3K1 gene

Genome Databases showing MAP3K1 gene

Other Databases showing MAP3K1 gene

Specialized Databases showing MAP3K1 gene

Intellectual Propertyfor MAP3K1 gene

Productsfor MAP3K1 gene

View Random Gene

Aliases
for MAP3K1 gene

Summaries
for MAP3K1 gene

Genomic Views
for MAP3K1 gene

Proteins
for MAP3K1 gene

Protein Domains /
Families
for MAP3K1 gene

Function
for MAP3K1 gene

Pathways & Interactions
for MAP3K1 gene

Drugs & Compounds
for MAP3K1 gene

Transcripts
for MAP3K1 gene

Expression
for MAP3K1 gene

Orthologs
for MAP3K1 gene

Paralogs
for MAP3K1 gene

Genomic Variants
for MAP3K1 gene

Disorders / Diseases
for MAP3K1 gene

Publications
for MAP3K1 gene

Intellectual Property
for MAP3K1 gene

Products
for MAP3K1 gene