Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MAP3K1 Gene

Aliases for MAP3K1 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 1, E3 Ubiquitin Protein Ligase 2 3
  • MEKK1 3 4 6
  • MEKK 3 4 6
  • Mitogen-Activated Protein Kinase Kinase Kinase 1 2 3
  • MAPK/ERK Kinase Kinase 1 3 4
  • MEK Kinase 1 3 4
  • MAPKKK1 3 4
  • MEKK 1 3 4
  • SRXY6 3 6
  • MAP/ERK Kinase Kinase 1 3
  • EC 2.7.11.25 4

External Ids for MAP3K1 Gene

Previous Symbols for MAP3K1 Gene

  • MEKK1

Summaries for MAP3K1 Gene

Entrez Gene Summary for MAP3K1 Gene

  • The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]

GeneCards Summary for MAP3K1 Gene

MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with MAP3K1 include 46xy sex reversal 6 and 46,xy partial gonadal dysgenesis. Among its related pathways are PI-3K cascade and MAPK signaling pathway. GO annotations related to this gene include protein kinase binding and MAP kinase kinase kinase activity. An important paralog of this gene is MAP3K5.

UniProtKB/Swiss-Prot for MAP3K1 Gene

  • Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.

Gene Wiki entry for MAP3K1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K1 Gene

Genomics for MAP3K1 Gene

Genomic Location for MAP3K1 Gene

Start:
56,815,073 bp from pter
End:
56,896,152 bp from pter
Size:
81,080 bases
Orientation:
Plus strand

Genomic View for MAP3K1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP3K1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K1 Gene

Regulatory Elements for MAP3K1 Gene

Proteins for MAP3K1 Gene

  • Protein details for MAP3K1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13233-M3K1_HUMAN
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 1
    Protein Accession:
    Q13233
    Secondary Accessions:

    Protein attributes for MAP3K1 Gene

    Size:
    1512 amino acids
    Molecular mass:
    164470 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds both upstream activators and downstream substrates in multimolecular complexes through its N-terminus. Oligomerizes after binding MAP4K2 or TRAF2. Interacts with AXIN1. Interacts (via the kinase catalytic domain) with STK38.

neXtProt entry for MAP3K1 Gene

Proteomics data for MAP3K1 Gene at MOPED

Post-translational modifications for MAP3K1 Gene

Other Protein References for MAP3K1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MAP3K1 Gene

Domains for MAP3K1 Gene

Gene Families for MAP3K1 Gene

HGNC:
  • MAP3K :Mitogen-activated protein kinase cascade / Kinase kinase kinases
IUPHAR :

UniProtKB/Swiss-Prot:

M3K1_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q13233
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.:
    • Q13233
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q13233
  • Contains 1 SWIM-type zinc finger.:
    • Q13233
genes like me logo Genes that share domains with MAP3K1: view

Function for MAP3K1 Gene

Molecular function for MAP3K1 Gene

GENATLAS Biochemistry: mitogen-activated protein (MAP/ERK) kinase kinase kinase 1,stress activated protein kinase,exercizing an antiapoptotic function as activator of C-Jun amino-terminal kinase (JNK) in response to changes in the microtubule cytoskeleton and extra signal-regulated protein kinase (ERK),also involved in apoptosis as caspase-3 substrate and in the induction of apoptosis by genotoxins but not by microtubule altering drugs. Stimulating MADH2 mediated transcriptional activation in endothelial cells
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by autophosphorylation on Thr-1400 and Thr-1412 following oligomerization
UniProtKB/Swiss-Prot Function: Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.

Enzyme Numbers (IUBMB) for MAP3K1 Gene

Gene Ontology (GO) - Molecular Function for MAP3K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 15001576
GO:0004709 MAP kinase kinase kinase activity NAS 9808624
GO:0004713 protein tyrosine kinase activity --
GO:0005488 binding --
GO:0005515 protein binding IPI 11784851
genes like me logo Genes that share ontologies with MAP3K1: view
genes like me logo Genes that share phenotypes with MAP3K1: view

Animal Models for MAP3K1 Gene

MGI Knock Outs for MAP3K1:

No data available for Transcription Factor Targeting and HOMER Transcription for MAP3K1 Gene

Localization for MAP3K1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP3K1 Gene COMPARTMENTS Subcellular localization image for MAP3K1 gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for MAP3K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAP3K1: view

Pathways for MAP3K1 Gene

genes like me logo Genes that share pathways with MAP3K1: view

Gene Ontology (GO) - Biological Process for MAP3K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity NAS 9808624
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0003382 epithelial cell morphogenesis IEA --
GO:0006468 protein phosphorylation NAS 9808624
genes like me logo Genes that share ontologies with MAP3K1: view

Compounds for MAP3K1 Gene

(4) ApexBio Compounds for MAP3K1 Gene

Compound Action Cas Number
FR 180204 Selective ERK inhibitor [865362-74-9]
VX-11e potent, selective, and orally bioavailable inhibitor of ERK [896720-20-0]
XMD17-109 novel, specific ERK-5 inhibitor with an EC50 4.2uM in HEK293 cells [1435488-37-1]
XMD8-92 highly selective ERK5/BMK1 inhibitor [1234480-50-2]

(3) HMDB Compounds for MAP3K1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(42) Novoseek inferred chemical compound relationships for MAP3K1 Gene

Compound -log(P) Hits PubMed IDs
anisomycin 63.4 3
sp 600125 58.4 6
pd 98,059 56.2 7
sb 203580 52.7 4
threonine 51.7 4

(6) PharmGKB related drug/compound annotations for MAP3K1 Gene

Drug/compound Annotation
carboplatin CA
cisplatin CA
docetaxel CA
erlotinib CA
gefitinib CA
paclitaxel CA
genes like me logo Genes that share compounds with MAP3K1: view

Transcripts for MAP3K1 Gene

Unigene Clusters for MAP3K1 Gene

Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b
SP1:
SP2:

Relevant External Links for MAP3K1 Gene

GeneLoc Exon Structure for
MAP3K1
ECgene alternative splicing isoforms for
MAP3K1

Expression for MAP3K1 Gene

mRNA expression in normal human tissues for MAP3K1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP3K1 Gene

This gene is overexpressed in Whole Blood (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP3K1 Gene

SOURCE GeneReport for Unigene cluster for MAP3K1 Gene Hs.653654

genes like me logo Genes that share expressions with MAP3K1: view

Orthologs for MAP3K1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP3K1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP3K1 36
  • 99.51 (n)
  • 99.34 (a)
MAP3K1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAP3K1 36
  • 92.25 (n)
  • 93.82 (a)
MAP3K1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP3K1 36
  • 92.47 (n)
  • 93.89 (a)
MAP3K1 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map3k1 36
  • 85.52 (n)
  • 90.52 (a)
Map3k1 16
Map3k1 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP3K1 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP3K1 37
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100912399 36
  • 86.22 (n)
  • 90.37 (a)
chicken
(Gallus gallus)
Aves MAP3K1 36
  • 79.32 (n)
  • 83.29 (a)
MAP3K1 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP3K1 37
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12302 36
tropical clawed frog
(Silurana tropicalis)
Amphibia map3k1 36
  • 73.77 (n)
  • 78.12 (a)
zebrafish
(Danio rerio)
Actinopterygii map3k1 36
  • 67.37 (n)
  • 74.27 (a)
map3k1 37
  • 68 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BCK1 37
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
OneToOne
Species with no ortholog for MAP3K1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP3K1 Gene

ENSEMBL:
Gene Tree for MAP3K1 (if available)
TreeFam:
Gene Tree for MAP3K1 (if available)

Paralogs for MAP3K1 Gene

Paralogs for MAP3K1 Gene

Selected SIMAP similar genes for MAP3K1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MAP3K1: view

Variants for MAP3K1 Gene

Sequence variations from dbSNP and Humsavar for MAP3K1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs33322 -- 56,879,399(+) AGTTG(A/G)CATTT intron-variant
rs33323 -- 56,879,739(+) CCCTT(C/G)CATAA intron-variant
rs33324 -- 56,845,763(+) CCAAG(A/G)ACACA intron-variant
rs33325 -- 56,846,720(+) GTTTT(C/G)ACTTC intron-variant
rs33326 -- 56,846,774(+) TTTCC(A/G)TGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP3K1 Gene

Variant ID Type Subtype PubMed ID
nsv830308 CNV Gain 17160897
esv23998 CNV Loss 19812545
esv2730198 CNV Deletion 23290073
esv2730199 CNV Deletion 23290073
esv2375620 CNV Deletion 18987734
nsv329292 CNV Loss 16902084
esv1000409 CNV Deletion 20482838
esv1751401 CNV Deletion 17803354
nsv329673 CNV Loss 16902084

Relevant External Links for MAP3K1 Gene

HapMap Linkage Disequilibrium report
MAP3K1
Human Gene Mutation Database (HGMD)
MAP3K1

Disorders for MAP3K1 Gene

(1) OMIM Diseases for MAP3K1 Gene (600982)

UniProtKB/Swiss-Prot

M3K1_HUMAN
  • 46,XY sex reversal 6 (SRXY6) [MIM:613762]: A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. {ECO:0000269 PubMed:21129722}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for MAP3K1 Gene

(20) Novoseek inferred disease relationships for MAP3K1 Gene

Disease -log(P) Hits PubMed IDs
necrosis 38.5 11
tumors 26 15
pancreatic cancer 14.3 8
cancer 13.6 5
leukemogenesis 8.13 1

Relevant External Links for MAP3K1

Genetic Association Database (GAD)
MAP3K1
Human Genome Epidemiology (HuGE) Navigator
MAP3K1
genes like me logo Genes that share disorders with MAP3K1: view

Publications for MAP3K1 Gene

  1. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. (PMID: 9808624) Xia Y. … Karin M. (Genes Dev. 1998) 3 4 23
  2. Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5. (PMID: 8597633) Vinik B.S. … Fiedorek F.T. Jr. (Mamm. Genome 1995) 2 3 4
  3. SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling. (PMID: 12223491) Rui H.L. … Lin S.C. (J. Biol. Chem. 2002) 3 4
  4. Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). (PMID: 17906693) Enomoto A. … Miyagawa K. (Oncogene 2008) 3 4
  5. Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases. (PMID: 17997823) Huijts P.E. … van Asperen C.J. (Breast Cancer Res. 2007) 3 49

Products for MAP3K1 Gene

Sources for MAP3K1 Gene

Back to Top

Content