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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP3K1 Gene

protein-coding   GIFtS: 68
GCID: GC05P056110

Mitogen-Activated Protein Kinase Kinase Kinase 1, E3 Ubiquitin...

(Previous name: mitogen-activated protein kinase kinase kinase 1)
(Previous symbol: MEKK1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 1, E3 Ubiquitin Protein
Ligase1 2
     MEK Kinase 12 3
MEKK11 2 3 5     MEKK 12 3
MEKK2 3 5     SRXY62
Mitogen-Activated Protein Kinase Kinase Kinase 11 2     MAP/ERK Kinase Kinase 12
MAPKKK12 3     EC 2.7.11.253
MAPK/ERK Kinase Kinase 12 3     

External Ids:    HGNC: 68481   Entrez Gene: 42142   Ensembl: ENSG000000950157   OMIM: 6009825   UniProtKB: Q132333   

Export aliases for MAP3K1 gene to outside databases

Previous GC identifers: GC05P056276 GC05P057669 GC05P056081 GC05P056126 GC05P056146 GC05P053082


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAP3K1 Gene:
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades,
including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by
autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3
ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by
a kinase domain in its C-terminus. (provided by RefSeq, Mar 2012)

GeneCards Summary for MAP3K1 Gene: 
MAP3K1 (mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with MAP3K1 include breast cancer susceptibility, and disorders of sex development, and among its related super-pathways are Development HGF signaling pathway and Apoptosis and survival FAS signaling cascades. GO annotations related to this gene include protein kinase binding and MAP kinase kinase kinase activity. An important paralog of this gene is MAP3K3.

UniProtKB/Swiss-Prot: M3K1_HUMAN, Q13233
Function: Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by
phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B
pathway

Gene Wiki entry for MAP3K1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006713.15  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP3K1 gene promoter:
         Sp1   p53   AP-1   ATF-2   STAT3   c-Jun   C/EBPalpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MAP3K1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP3K1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

MAP3K1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P056110:  view genomic region     (about GC identifiers)

Start:
56,110,900 bp from pter      End:
56,191,979 bp from pter
Size:
81,080 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: M3K1_HUMAN, Q13233 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 1  
Size: 1512 amino acids; 164470 Da
Cofactor: Magnesium
Subunit: Binds both upstream activators and downstream substrates in multimolecular complexes through its
N-terminus. Oligomerizes after binding MAP4K2 or TRAF2. Interacts with AXIN1. Interacts (via the kinase catalytic
domain) with STK38

Explore the universe of human proteins at neXtProt for MAP3K1: NX_Q13233

Explore proteomics data for MAP3K1 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13233

  • MAP3K1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAP3K1 Protein Expression
    REFSEQ proteins: NP_005912.1  
    ENSEMBL proteins: 
     ENSP00000382423  
    Reactome Protein details: Q13233
    Human Recombinant Protein Products for MAP3K1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for MAP3K1
    GenScript Custom Purified and Recombinant Proteins Services for MAP3K1
    Novus Biologicals MAP3K1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAP3K1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    MAP3K1 for ontologies           About GeneDecksing



    MAP3K1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP3K1
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    Novus Biologicals MAP3K1 Antibodies
    Abcam antibodies for MAP3K1
    Cloud-Clone Corp. Antibodies for MAP3K1 
    ThermoFisher Antibodies for MAP3K1
    LSBio Antibodies in human, mouse, rat for MAP3K1 

    Assay Products for MAP3K1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAP3K1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAP3K1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAP3K1 
    Cloud-Clone Corp. CLIAs for MAP3K1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MAP3K: Mitogen-activated protein kinase cascade / Kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 
    STE11 family

    5/8 InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR001841 Znf_RING
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q13233

    ProtoNet protein and cluster: Q13233

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB007527 SWIM Zn-finger


    UniProtKB/Swiss-Prot: M3K1_HUMAN, Q13233
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 SWIM-type zinc finger


    MAP3K1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M3K1_HUMAN, Q13233
    Function: Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by
    phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B
    pathway
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by autophosphorylation on Thr-1400 and Thr-1412 following oligomerization

         Genatlas biochemistry entry for MAP3K1:
    mitogen-activated protein (MAP/ERK) kinase kinase kinase 1,stress activated protein kinase,exercizing an
    antiapoptotic function as activator of C-Jun amino-terminal kinase (JNK) in response to changes in the
    microtubule cytoskeleton and extra signal-regulated protein kinase (ERK),also involved in apoptosis as caspase-3
    substrate and in the induction of apoptosis by genotoxins but not by microtubule altering drugs. Stimulating
    MADH2 mediated transcriptional activation in endothelial cells

         Enzyme Number (IUBMB): EC 2.7.11.251

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS--
    GO:0004709MAP kinase kinase kinase activity NAS9808624
    GO:0004713protein tyrosine kinase activity ----
    GO:0005488binding ----
    GO:0005515protein binding IPI11784851
         
    MAP3K1 for ontologies           About GeneDecksing


    Phenotypes:
         12 GenomeRNAi human phenotypes for MAP3K1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased substrate adherent c 
     Decreased telomerase activity  Gemcitabine induced cell-death  Increased apoptosis  Increased colony dispersion (i 
     Synthetic lethal with Ras  Synthetic lethal with gemcitab  Upregulation of NF-kappaB path  Upregulation of Wnt/beta-caten 

         13 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Map3k1):
     behavior/neurological  cardiovascular system  cellular  homeostasis/metabolism  immune system 
     integument  mortality/aging  muscle  other  pigmentation 
     skeleton  tumorigenesis  vision/eye 

    MAP3K1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Map3k1tm1Glj for MAP3K1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAP3K1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAP3K1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP3K1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP3K1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAP3K1:
    hsa-mir-192 (MIRT004142)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP3K1
    8/121 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP3K1 (see all 121):
    hsa-miR-100* hsa-miR-640 hsa-miR-3607-3p hsa-miR-520e hsa-miR-411 hsa-miR-106a hsa-miR-938 hsa-miR-30d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAP3K1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP3K1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAP3K1
    Sirion Biotech Customized adenovirus for overexpression of MAP3K1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MAP3K1 (see all 7)
    OriGene ORF clones in mouse, rat for MAP3K1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAP3K1 (NM_005921)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP3K1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAP3K1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MAP3K1
    Search LifeMap BioReagents cell lines for MAP3K1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAP3K1 About   (see all 64)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development HGF signaling pathway
    Development HGF signaling pathway0.78
    Neurotrophin signaling pathway0.36
    Development Neurotrophin family signaling0.45
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.31
    Development PDGF signaling via MAPK cascades0.41
    2Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44
    Caspase cascade in apoptosis0.42
    FAS pathway and Stress induction of HSP regulation0.44
    3G-protein signaling Ras family GTPases in kinase cascades (scheme)
    G-protein signaling Ras family GTPases in kinase cascades (scheme)0.44
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    MAPK Cascade0.44
    4Development Endothelin-1/EDNRA signaling
    Development Endothelin-1/EDNRA signaling0.41
    GnRH signaling pathway0.38
    Cytoskeleton remodeling FAK signaling0.41
    5TWEAK Pathway
    Apoptosis and survival TNFR1 signaling pathway0.52
    Apoptosis Modulation by HSP700.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/30 EMD Millipore Pathways for MAP3K1 (see all 30)
        Cytoskeleton remodeling FAK signaling
    Apoptosis and survival FAS signaling cascades
    Immune response MIF in innate immunity response
    G-protein signaling G-Protein alpha-12 signaling pathway
    Immune response CCR3 signaling in eosinophils

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP3K1 (see all 9)
        Interferon Pathway
    CRHR Pathway
    TNFR2 Pathway
    NFAT and Cardiac Hypertrophy
    PACAP Signaling

    5/32 GeneGo (Thomson Reuters) Pathways for MAP3K1 (see all 32)
        Development A2A receptor signaling
    Immune response MIF in innate immunity response
    Transcription P53 signaling pathway
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins

    5/29 BioSystems Pathways for MAP3K1 (see all 29)
        MAPK signaling pathway
    Apoptosis
    EGFR1 Signaling Pathway
    DNA damage response (only ATM dependent)
    Insulin Signaling

    5/20        Reactome Pathways for MAP3K1 (see all 20)
        FCERI mediated MAPK activation
    Toll Like Receptor 2 (TLR2) Cascade
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll-Like Receptors Cascades

    2 PharmGKB Pathways for MAP3K1
        EGFR Inhibitor Pathway, Pharmacodynamics
    Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    5/7         Kegg Pathways  (Kegg details for MAP3K1) (see all 7):
        MAPK signaling pathway
    Ubiquitin mediated proteolysis
    RIG-I-like receptor signaling pathway
    Neurotrophin signaling pathway
    GnRH signaling pathway


    MAP3K1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP3K1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/235 Interacting proteins for MAP3K1 (Q132331, 2, 3 ENSP000003824234) via UniProtKB, MINT, STRING, and/or I2D (see all 235)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628052, 3MINT-48337 I2D: score=2 
    HIST1H4BP628052, 3MINT-48337 I2D: score=2 
    HIST1H4CP628052, 3MINT-48337 I2D: score=2 
    HIST1H4DP628052, 3MINT-48337 I2D: score=2 
    HIST1H4EP628052, 3MINT-48337 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity NAS9808624
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0006468protein phosphorylation NAS9808624
    GO:0007179transforming growth factor beta receptor signaling pathway IEA--

    MAP3K1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP3K1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP3K1 (M3K1)

    3 HMDB Compounds for MAP3K1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    10/42 Novoseek inferred chemical compound relationships for MAP3K1 gene (see all 42)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anisomycin 63.4 3 16434970 (1), 7935449 (1), 10506143 (1)
    sp 600125 58.4 6 16452190 (3), 17078934 (1), 15001534 (1), 16771680 (1)
    pd 98,059 56.2 7 10601300 (1), 10753939 (1), 11160424 (1), 14737074 (1) (see all 7)
    sb 203580 52.7 5 12506144 (1), 11315998 (1), 12472895 (1), 11062239 (1)
    threonine 51.7 4 9405407 (1), 9820741 (1), 11337492 (1), 18308848 (1)
    curcumin 48.6 3 9674701 (1), 10942386 (1), 9918209 (1)
    rottlerin 48.1 1 18160487 (1)
    12-o-tetradecanoylphorbol 13-acetate 41.9 11 9858570 (3), 11042219 (2), 8073291 (2), 9733728 (1) (see all 5)
    geranylgeraniol 41.1 1 11086177 (1)
    serine 39.2 4 9405407 (1), 11278353 (1), 9820741 (1), 11337492 (1)

    Search CenterWatch for drugs/clinical trials and news about MAP3K1 / M3K1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAP3K1 gene: 
    NM_005921.1  

    Unigene Cluster for MAP3K1:

    Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
    Hs.653654  [show with all ESTs]
    Unigene Representative Sequence: NM_005921
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399503(uc003jqw.4) ENST00000469188
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP3K1
    8/121 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP3K1 (see all 121):
    hsa-miR-100* hsa-miR-640 hsa-miR-3607-3p hsa-miR-520e hsa-miR-411 hsa-miR-106a hsa-miR-938 hsa-miR-30d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAP3K1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP3K1
    Clone
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    OriGene clones in human, mouse for MAP3K1 (see all 7)
    OriGene ORF clones in mouse, rat for MAP3K1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAP3K1 (NM_005921)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP3K1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAP3K1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MAP3K1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAP3K1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP3K1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP3K1

    Additional mRNA sequence: 

    AF042838.1 AK307828.1 BX537527.1 U56433.1 

    4 DOTS entries:

    DT.100642426  DT.112213  DT.97760286  DT.40131820 

    24/82 AceView cDNA sequences (see all 82):

    BE349320 AI074721 AL135609 AW235188 BE645815 AA464694 AW572284 AI804275 
    AA834992 BQ024720 AI125918 AW511515 BE041542 AU132367 AA864536 BM751575 
    AW452698 AI263934 BX096276 BQ016488 AI536651 BM148300 BE075691 BX498716 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b
    SP1:                                                                                                                                    
    SP2:                                                                                                                                    


    ECgene alternative splicing isoforms for MAP3K1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP3K1 expression in normal human tissues (normalized intensities)      MAP3K1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCACCACAT
    MAP3K1 Expression
    About this image


    MAP3K1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
             Cerebral Cortex
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   

    See MAP3K1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP3K1

    SOURCE GeneReport for Unigene cluster: Hs.653654
        SABiosciences Expression via Pathway-Focused PCR Arrays including MAP3K1 (see all 8): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat
              NFKB Signaling Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAP3K1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map3k11 , 5 mitogen-activated protein kinase kinase kinase 11, 5 85.99(n)1
    91.39(a)1
      13 (63.36 cM)5
    264011  NM_011945.21  NP_036075.21 
     1117464285 
    chicken
    (Gallus gallus)
    Aves MAP3K11 mitogen-activated protein kinase kinase kinase 1 80.48(n)
    84.77(a)
      427144  XM_424734.3  XP_424734.3 
    lizard
    (Anolis carolinensis)
    Reptilia MAP3K16
    Uncharacterized protein
    85(a)
    1 ↔ 1
    2(1891695-1921674)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.123022 Xenopus laevis transcribed sequence with moderate similarity more 77.6(n)    BU904431.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003344861 mitogen-activated protein kinase kinase kinase 1-like 65.79(n)
    71.31(a)
      100334486  XM_002663485.2  XP_002663531.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STE116
    BCK16
    Signal transducing MEK kinase involved in pheromon...
    Mitogen-activated protein (MAP) kinase kinase kina...
    19(a)
    12(a)
    many ↔ many
    many ↔ many
    XII(849866-852019)
    X(247255-251691)


    ENSEMBL Gene Tree for MAP3K1 (if available)
    TreeFam Gene Tree for MAP3K1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP3K1 gene
    MAP3K32  MAP3K52  MAP3K152  MAP3K22  MAP3K82  MAP3K192  MAP3K62  
    11 SIMAP similar genes for MAP3K1 using alignment to 2 protein entries:     M3K1_HUMAN (see all proteins):
    MAP3K2    DKFZp564L2416    MST094    NEK6    STK11    MAP2K5
    MYO3A    CDK4    NUAK1    PAK4    PRKAA1

    MAP3K1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1777 SNPs in MAP3K1 are shown (see all 1777)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0655044
    46,XY sex reversal 6 (SRXY6)4--see VAR_0655042 L P mis40--------
    VAR_0655054
    46,XY sex reversal 6 (SRXY6)4--see VAR_0655052 L R mis40--------
    rs1438535901,2,4
    C46,XY sex reversal 6 (SRXY6)4 --56108048(+) CGAGTA/GGGGGA 2 R G mis10--------
    VAR_0406814
    ----see VAR_0406812 C S mis40--------
    VAR_0406804
    ----see VAR_0406802 S N mis40--------
    rs38323601,2
    C--53101950(-) TACTA-/TA    
       T
    /TTA
    CTGAA
    2 -- cds10--------
    rs669605241,2
    C--53104077(+) ACTAC-/GAGCCA 1 -- int10--------
    rs344957451,2
    C--53115861(+) AAAAAA/-TTGAT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs609345121,2
    C--53117127(+) AAAAA-/A/GGAATC 1 -- int11NA 2
    rs1402393851,2
    C--53145272(+) TATAA-/TTTTTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for MAP3K1 (56110900 - 56191979 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for MAP3K1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1751401CNV Deletion17803354
    esv2730199CNV Deletion23290073
    esv2730198CNV Deletion23290073
    esv1000409CNV Deletion20482838
    esv2375620CNV Deletion18987734
    nsv329292CNV Loss16902084
    esv23998CNV Loss19812545
    nsv329673CNV Loss16902084
    nsv830308CNV Gain17160897


    Human Gene Mutation Database (HGMD): MAP3K1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP3K1
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP3K1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600982    OMIM disorders: --

    UniProtKB/Swiss-Prot: M3K1_HUMAN, Q13233
  • 46,XY sex reversal 6 (SRXY6) [MIM:613762]: A disorder of sex development. Affected individuals have a
    46,XY karyotype but present as phenotypically normal females. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 20/32 diseases for MAP3K1 (see all 32):    About MalaCards
    breast cancer susceptibility    disorders of sex development    familial adenomatous polyposis    pheochromocytoma
    familial breast cancer    polycystic kidney disease    kidney disease    pancreatic cancer
    kaposi's sarcoma    bronchiolitis    breast cancer    myeloid leukemia
    crohn's disease    myeloma    pancreatitis    ovarian cancer
    sarcoma    prostate cancer    melanoma    rheumatoid arthritis

    1 disease from the University of Copenhagen DISEASES database for MAP3K1:
    Breast cancer

    MAP3K1 for disorders           About GeneDecksing

    10/20 Novoseek inferred disease relationships for MAP3K1 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 38.5 12 12584189 (2), 9395240 (1), 11784851 (1), 10805784 (1) (see all 10)
    tumors 26 20 16568086 (3), 12584189 (2), 9395240 (1), 11784851 (1) (see all 12)
    pancreatic cancer 14.3 12 12185592 (3), 15767210 (2), 19513748 (2), 12963995 (1)
    cancer 13.6 5 15767210 (2), 15072767 (1), 16568086 (1), 12185592 (1)
    leukemogenesis 8.13 1 16044153 (1)
    myeloid leukemia 2.02 1 9858570 (1)
    leukemia t-cell 1.98 1 10648602 (1)
    cancer lung 0 1 14612408 (1)
    myeloma 0 1 14737074 (1)
    breast cancer 0 3 16568086 (1), 17681752 (1), 11509655 (1)

    Genetic Association Database (GAD): MAP3K1
    Human Genome Epidemiology (HuGE) Navigator: MAP3K1 (32 documents)

    Export disorders for MAP3K1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP3K1 gene, integrated from 9 sources (see all 413):
    (articles sorted by number of sources associating them with MAP3K1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5. (PubMed id 8597633)1, 2, 3 Vinik B.S.... Fiedorek F.T. Jr. (1995)
    2. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. (PubMed id 9808624)1, 2, 9 Xia Y.... Karin M. (1998)
    3. SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling. (PubMed id 12223491)1, 2, 9 Rui H.L....Lin S.C. (2002)
    4. Mutations in MAP3K1 cause 46,XY disorders of sex deve lopment and implicate a common signal transduction pathway in human testis dete rmination. (PubMed id 21129722)1, 2 Pearlman A....Ostrer H. (2010)
    5. FGFR2 and other loci identified in genome-wide associ ation studies are associated with breast cancer in African-American and younger women. (PubMed id 20554749)1, 4 Barnholtz-Sloan J.S....Millikan R.C. (2010)
    6. Distribution of FGFR2, TNRC9, MAP3K1, LSP1, and 8q24 alleles in genetically enriched breast cancer patients versus elderly tumor-fre e women. (PubMed id 20417875)1, 4 Gorodnova T.V....Imyanitov E.N. (2010)
    7. Common genetic variants associated with breast cancer and mammographic density measures that predict disease. (PubMed id 20145138)1, 4 Odefrey F....Southey M.C. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Performance of common genetic variants in breast-canc er risk models. (PubMed id 20237344)1, 4 Wacholder S....Hunter D.J. (2010)
    10. Gene-environment interactions in 7610 women with brea st cancer: prospective evidence from the Million Women Study. (PubMed id 20605201)1, 4 Travis R.C....Lathrop M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4214 HGNC: 6848 AceView: MAP3K1 Ensembl:ENSG00000095015 euGenes: HUgn4214
    ECgene: MAP3K1 Kegg: 4214 H-InvDB: MAP3K1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP3K1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAP3K1 gene:
    Search GeneIP for patents involving MAP3K1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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