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MAP3K1 Gene

protein-coding   GIFtS: 68
GCID: GC05P056110

Mitogen-Activated Protein Kinase Kinase Kinase 1, E3 Ubiquitin...

(Previous name: mitogen-activated protein kinase kinase kinase 1)
(Previous symbol: MEKK1)
  See MAP3K1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase Kinase Kinase 1, E3 Ubiquitin Protein
Ligase1 2
     MEK Kinase 12 3
MEKK11 2 3 5     MEKK 12 3
MEKK2 3 5     SRXY62 5
Mitogen-Activated Protein Kinase Kinase Kinase 11 2     MAP/ERK Kinase Kinase 12
MAPKKK12 3     EC 2.7.11.253
MAPK/ERK Kinase Kinase 12 3     

External Ids:    HGNC: 68481   Entrez Gene: 42142   Ensembl: ENSG000000950157   OMIM: 6009825   UniProtKB: Q132333   

Export aliases for MAP3K1 gene to outside databases

Previous GC identifers: GC05P056276 GC05P057669 GC05P056081 GC05P056126 GC05P056146 GC05P053082


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP3K1 Gene:
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades,
including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by
autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3
ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by
a kinase domain in its C-terminus. (provided by RefSeq, Mar 2012)

GeneCards Summary for MAP3K1 Gene:
MAP3K1 (mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with MAP3K1 include 46xy sex reversal 3, and 46,xy disorder of sex development and 46,xy complete gonadal dysgenesis. GO annotations related to this gene include protein kinase binding and MAP kinase kinase kinase activity. An important paralog of this gene is MAP3K3.

UniProtKB/Swiss-Prot: M3K1_HUMAN, Q13233
Function: Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by
phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B
pathway

Gene Wiki entry for MAP3K1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP3K1 gene promoter:
         Sp1   p53   AP-1   ATF-2   STAT3   c-Jun   C/EBPalpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MAP3K1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP3K1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

MAP3K1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP3K1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P056110:  view genomic region     (about GC identifiers)

Start:
56,110,900 bp from pter      End:
56,191,979 bp from pter
Size:
81,080 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: M3K1_HUMAN, Q13233 (See protein sequence)
Recommended Name: Mitogen-activated protein kinase kinase kinase 1  
Size: 1512 amino acids; 164470 Da
Cofactor: Magnesium
Subunit: Binds both upstream activators and downstream substrates in multimolecular complexes through its
N-terminus. Oligomerizes after binding MAP4K2 or TRAF2. Interacts with AXIN1. Interacts (via the kinase catalytic
domain) with STK38

Explore the universe of human proteins at neXtProt for MAP3K1: NX_Q13233

Explore proteomics data for MAP3K1 at MOPED

Post-translational modifications: 

  • Autophosphorylated (By similarity)1
  • Ubiquitination2 at Lys1398
  • Modification sites at PhosphoSitePlus

  • See MAP3K1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005912.1  
    ENSEMBL proteins: 
     ENSP00000382423  
    Reactome Protein details: Q13233

    MAP3K1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MAP3K1
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MAP3K1
    GenScript Custom Purified and Recombinant Proteins Services for MAP3K1
    Novus Biologicals MAP3K1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAP3K1

     
    Search eBioscience for Proteins for MAP3K1 

    MAP3K1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP3K1
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    OriGene Antibodies for MAP3K1
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    Novus Biologicals MAP3K1 Antibodies
    Abcam antibodies for MAP3K1
    Cloud-Clone Corp. Antibodies for MAP3K1
    ThermoFisher Antibodies for MAP3K1
    LSBio Antibodies in human, mouse, rat for MAP3K1

    MAP3K1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MAP3K1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAP3K1
    Cloud-Clone Corp. CLIAs for MAP3K1
    Search eBioscience for ELISAs for MAP3K1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAP3K: Mitogen-activated protein kinase cascade / Kinase kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
    STE11 family

    Selected InterPro protein domains (see all 9):
     IPR017441 Protein_kinase_ATP_BS
     IPR001841 Znf_RING
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q13233

    ProtoNet protein and cluster: Q13233

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB007527 SWIM Zn-finger


    UniProtKB/Swiss-Prot: M3K1_HUMAN, Q13233
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 SWIM-type zinc finger


    Find genes that share domains with MAP3K1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: M3K1_HUMAN, Q13233
    Function: Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by
    phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B
    pathway
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by autophosphorylation on Thr-1400 and Thr-1412 following oligomerization

         Genatlas biochemistry entry for MAP3K1:
    mitogen-activated protein (MAP/ERK) kinase kinase kinase 1,stress activated protein kinase,exercizing an
    antiapoptotic function as activator of C-Jun amino-terminal kinase (JNK) in response to changes in the
    microtubule cytoskeleton and extra signal-regulated protein kinase (ERK),also involved in apoptosis as caspase-3
    substrate and in the induction of apoptosis by genotoxins but not by microtubule altering drugs. Stimulating
    MADH2 mediated transcriptional activation in endothelial cells

         Enzyme Number (IUBMB): EC 2.7.11.251

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA15001576
    GO:0004709MAP kinase kinase kinase activity NAS9808624
    GO:0004713protein tyrosine kinase activity ----
    GO:0005488binding ----
    GO:0005515protein binding IPI11784851
         
    Find genes that share ontologies with MAP3K1           About GenesLikeMe


    Phenotypes:
         12 GenomeRNAi human phenotypes for MAP3K1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased substrate adherent c 
     Decreased telomerase activity  Gemcitabine induced cell-death  Increased apoptosis  Increased colony dispersion (i 
     Synthetic lethal with Ras  Synthetic lethal with gemcitab  Upregulation of NF-kappaB path  Upregulation of Wnt/beta-caten 

         13 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Map3k1):
     behavior/neurological  cardiovascular system  cellular  homeostasis/metabolism  immune system 
     integument  mortality/aging  muscle  other  pigmentation 
     skeleton  tumorigenesis  vision/eye 

    Find genes that share phenotypes with MAP3K1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Map3k1tm1Glj for MAP3K1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAP3K1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAP3K1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP3K1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP3K1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAP3K1:
    hsa-mir-125a-5p (MIRT045762), hsa-mir-21-5p (MIRT031009), hsa-mir-423-3p (MIRT042622), hsa-let-7a-5p (MIRT052565), hsa-mir-34a-5p (MIRT047383), hsa-let-7g-5p (MIRT046560), hsa-mir-192-5p (MIRT004142)

    Block miRNA regulation of human, mouse, rat MAP3K1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP3K1 (see all 121):
    hsa-miR-100* hsa-miR-640 hsa-miR-3607-3p hsa-miR-520e hsa-miR-411 hsa-miR-106a hsa-miR-938 hsa-miR-30d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAP3K1
    Predesigned siRNA for gene silencing in human, mouse, rat MAP3K1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAP3K1

    Clone
    Products:
         
    OriGene clones in human, mouse for MAP3K1 (see all 9)
    OriGene ORF clones in mouse, rat for MAP3K1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAP3K1 (NM_005921)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP3K1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAP3K1
    Addgene plasmids for MAP3K1 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MAP3K1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with MAP3K1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP3K1 About   (see all 64)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44
    Caspase cascade in apoptosis0.42
    FAS pathway and Stress induction of HSP regulation0.44
    2Development HGF signaling pathway
    Development HGF signaling pathway0.45
    Development PDGF signaling via MAPK cascades0.41
    Development Neurotrophin family signaling0.45
    Neurotrophin signaling pathway0.36
    3G protein signaling Ras family GTPases in kinase cascades scheme
    G protein signaling Ras family GTPases in kinase cascades scheme 0.44
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    MAPK Cascade0.44
    4Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    GnRH signaling pathway0.38
    Cytoskeleton remodeling FAK signaling0.41
    5TWEAK Pathway
    Apoptosis and survival TNFR1 signaling pathway0.52
    Apoptosis Modulation by HSP700.35


    Find genes that share SuperPaths with MAP3K1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAP3K1 (see all 9)
        Interferon Pathway
    CRHR Pathway
    TNFR2 Pathway
    NFAT and Cardiac Hypertrophy
    PACAP Signaling

    Selected GeneGo (Thomson Reuters) Pathways for MAP3K1 (see all 32)
        Development A2A receptor signaling
    Immune response MIF in innate immunity response
    Transcription P53 signaling pathway
    Development Endothelin-1/EDNRA signaling
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins

    Selected BioSystems Pathways for MAP3K1 (see all 30)
        MAPK signaling pathway
    Apoptosis
    EGFR1 Signaling Pathway
    Insulin Signaling
    DNA damage response (only ATM dependent)

    5 Reactome Pathways for MAP3K1
        FCERI mediated MAPK activation
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
    MyD88:Mal cascade initiated on plasma membrane
    TRAF6 mediated NF-kB activation
    MyD88 cascade initiated on plasma membrane

    2 PharmGKB Pathways for MAP3K1
        EGFR Inhibitor Pathway, Pharmacodynamics
    Tacrolimus/Cyclosporine Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for MAP3K1) (see all 7):
        MAPK signaling pathway
    Ubiquitin mediated proteolysis
    RIG-I-like receptor signaling pathway
    Neurotrophin signaling pathway
    GnRH signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP3K1 (see all 8): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat
              NFKB Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAP3K1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAP3K1 (Q132331, 2, 3 ENSP000003824234) via UniProtKB, MINT, STRING, and/or I2D (see all 317)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCAF7P619621, 2, 3, ENSP000003083444EBI-49776,EBI-359808 MINT-8085204 MINT-8085171 MINT-8088896 MINT-8085134 MINT-48280 MINT-8085187 MINT-47978 MINT-8085083 I2D: score=3 STRING: ENSP00000308344
    HIST1H4AP628052, 3MINT-48337 I2D: score=2 
    HIST1H4BP628052, 3MINT-48337 I2D: score=2 
    HIST1H4CP628052, 3MINT-48337 I2D: score=2 
    HIST1H4DP628052, 3MINT-48337 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity NAS9808624
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0003382epithelial cell morphogenesis IEA--
    GO:0006468protein phosphorylation NAS9808624

    Find genes that share ontologies with MAP3K1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    4 ApexBio Compounds for MAP3K1     About this table
    CompoundAction CAS #
    FR 180204Selective ERK inhibitor[865362-74-9]
    VX-11epotent, selective, and orally bioavailable inhibitor of ERK[896720-20-0]
    XMD17-109novel, specific ERK-5 inhibitor with an EC50 4.2uM in HEK293 cells[1435488-37-1]
    XMD8-92highly selective ERK5/BMK1 inhibitor[1234480-50-2]

    Browse Tocris compounds for MAP3K1 (M3K1)

    3 HMDB Compounds for MAP3K1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Selected Novoseek inferred chemical compound relationships for MAP3K1 gene (see all 42)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anisomycin 63.4 3 16434970 (1), 7935449 (1), 10506143 (1)
    sp 600125 58.4 6 16452190 (3), 17078934 (1), 15001534 (1), 16771680 (1)
    pd 98,059 56.2 7 10601300 (1), 10753939 (1), 11160424 (1), 14737074 (1) (see all 7)
    sb 203580 52.7 5 12506144 (1), 11315998 (1), 12472895 (1), 11062239 (1)
    threonine 51.7 4 9405407 (1), 9820741 (1), 11337492 (1), 18308848 (1)
    curcumin 48.6 3 9674701 (1), 10942386 (1), 9918209 (1)
    rottlerin 48.1 1 18160487 (1)
    12-o-tetradecanoylphorbol 13-acetate 41.9 11 9858570 (3), 11042219 (2), 8073291 (2), 9733728 (1) (see all 5)
    geranylgeraniol 41.1 1 11086177 (1)
    serine 39.2 4 9405407 (1), 11278353 (1), 9820741 (1), 11337492 (1)

    6 PharmGKB related drug/compound annotations for MAP3K1 gene    About this table
    Drug/compound PharmGKB Annotation
    carboplatinCA  
    cisplatinCA  
    docetaxelCA  
    erlotinibCA  
    gefitinibCA  
    paclitaxelCA  



    Find genes that share compounds with MAP3K1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAP3K1 gene: 
    NM_005921.1  

    Unigene Cluster for MAP3K1:

    Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
    Hs.653654  [show with all ESTs]
    Unigene Representative Sequence: NM_005921
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000399503(uc003jqw.4) ENST00000469188
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MAP3K1 (see all 121):
    hsa-miR-100* hsa-miR-640 hsa-miR-3607-3p hsa-miR-520e hsa-miR-411 hsa-miR-106a hsa-miR-938 hsa-miR-30d
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAP3K1 (NM_005921)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP3K1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAP3K1
    Addgene plasmids for MAP3K1 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAP3K1
      QuantiTect SYBR Green Assays in human, mouse, rat MAP3K1
      QuantiFast Probe-based Assays in human, mouse, rat MAP3K1

    Additional mRNA sequence: 

    AF042838.1 AK307828.1 BX537527.1 U56433.1 

    4 DOTS entries:

    DT.100642426  DT.112213  DT.97760286  DT.40131820 

    Selected AceView cDNA sequences (see all 82):

    BE349320 AA464694 BE041542 AL135609 AA834992 BE645815 AW572284 AA864536 
    AI074721 AW235188 BQ024720 AW511515 AU132367 AI804275 AI125918 BX537527 
    BX498716 AI332426 AI536651 AI760113 BQ883170 AF042838 AI927052 CD676868 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b
    SP1:                                                                                                                                    
    SP2:                                                                                                                                    


    ECgene alternative splicing isoforms for MAP3K1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAP3K1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCACCACAT
    MAP3K1 Expression
    About this image


    MAP3K1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
    MAP3K1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP3K1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.653654
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP3K1 (see all 8): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat
              NFKB Signaling Pathway in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP3K1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAP3K1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map3k11 , 5 mitogen-activated protein kinase kinase kinase 11, 5 85.52(n)1
    90.52(a)1
      13 (63.36 cM)5
    264011  NM_011945.21  NP_036075.21 
     1117464285 
    chicken
    (Gallus gallus)
    Aves MAP3K11 mitogen-activated protein kinase kinase kinase 1, E3 more 79.32(n)
    83.29(a)
      427144  XM_424734.4  XP_424734.3 
    lizard
    (Anolis carolinensis)
    Reptilia MAP3K16
    mitogen-activated protein kinase kinase kinase 1, ...
    85(a)
    1 ↔ 1
    2(1891695-1921674)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.123022 Xenopus laevis transcribed sequence with moderate similarity more 77.6(n)    BU904431.1 
    zebrafish
    (Danio rerio)
    Actinopterygii map3k11 mitogen-activated protein kinase kinase kinase 1, E3 more 67.37(n)
    74.27(a)
      100334486  XM_002663485.3  XP_002663531.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BCK16
    Mitogen-activated protein (MAP) kinase kinase kina...
    19(a)
    1 → many
    X(247255-251691) YJL095W


    ENSEMBL Gene Tree for MAP3K1 (if available)
    TreeFam Gene Tree for MAP3K1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP3K1 gene
    MAP3K32  MAP3K52  MAP3K152  MAP3K82  MAP3K22  MAP3K192  MAP3K62  
    11 SIMAP similar genes for MAP3K1 using alignment to 2 protein entries:     M3K1_HUMAN (see all proteins):
    MAP3K2    DKFZp564L2416    MST094    NEK6    STK11    MAP2K5
    MYO3A    CDK4    NUAK1    PAK4    PRKAA1

    Find genes that share paralogs with MAP3K1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP3K1 (see all 1777)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438535901,2,,4
    C46,XY sex reversal 6 (SRXY6)4 --56108048(+) CGAGTA/GGGGGA 2 R G mis10--------
    VAR_0655044
    46,XY sex reversal 6 (SRXY6)4--see VAR_0655042 L P mis40--------
    VAR_0655054
    46,XY sex reversal 6 (SRXY6)4--see VAR_0655052 L R mis40--------
    rs38323601,2
    C--53101950(-) TACTA-/TA    
       T
    /TTA
    CTGAA
    2 -- cds10--------
    rs669605241,2
    C--53104077(+) ACTAC-/GAGCCA 1 -- int10--------
    rs344957451,2
    C--53115861(+) AAAAAA/-TTGAT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs609345121,2
    C--53117127(+) AAAAA-/A/GGAATC 1 -- int11NA 2
    rs1402393851,2
    C--53145272(+) TATAA-/TTTTTTT 1 -- int10--------
    rs354867761,2
    C--53147314(+) AAAAAA/-TTTTT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs8325461,2
    C,A--53163113(-) AAAAAT/AAAAAA 1 -- ut312Minor allele frequency- A:0.25MN NA 186

    HapMap Linkage Disequilibrium report for MAP3K1 (56110900 - 56191979 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for MAP3K1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1751401CNV Deletion17803354
    esv2730199CNV Deletion23290073
    esv2730198CNV Deletion23290073
    esv1000409CNV Deletion20482838
    esv2375620CNV Deletion18987734
    nsv329292CNV Loss16902084
    esv23998CNV Loss19812545
    nsv329673CNV Loss16902084
    nsv830308CNV Gain17160897

    Human Gene Mutation Database (HGMD): MAP3K1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP3K1
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP3K1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600982   
    OMIM disorders: 613762  
    UniProtKB/Swiss-Prot: M3K1_HUMAN, Q13233
  • 46,XY sex reversal 6 (SRXY6) [MIM:613762]: A disorder of sex development. Affected individuals have a
    46,XY karyotype but present as phenotypically normal females. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 4 diseases for MAP3K1:    
    About MalaCards
    46xy sex reversal 3    46,xy disorder of sex development and 46,xy complete gonadal dysgenesis    46xy sex reversal 6    breast cancer susceptibility

    1 disease from the University of Copenhagen DISEASES database for MAP3K1:
    Breast cancer

    Find genes that share disorders with MAP3K1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MAP3K1 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 38.5 12 12584189 (2), 9395240 (1), 11784851 (1), 10805784 (1) (see all 10)
    tumors 26 20 16568086 (3), 12584189 (2), 9395240 (1), 11784851 (1) (see all 12)
    pancreatic cancer 14.3 12 12185592 (3), 15767210 (2), 19513748 (2), 12963995 (1)
    cancer 13.6 5 15767210 (2), 15072767 (1), 16568086 (1), 12185592 (1)
    leukemogenesis 8.13 1 16044153 (1)
    myeloid leukemia 2.02 1 9858570 (1)
    leukemia t-cell 1.98 1 10648602 (1)
    cancer lung 0 1 14612408 (1)
    myeloma 0 1 14737074 (1)
    breast cancer 0 3 16568086 (1), 17681752 (1), 11509655 (1)

    Genetic Association Database (GAD): MAP3K1
    Human Genome Epidemiology (HuGE) Navigator: MAP3K1 (32 documents)

    Export disorders for MAP3K1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP3K1 gene, integrated from 10 sources (see all 417):
    (articles sorted by number of sources associating them with MAP3K1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5. (PubMed id 8597633)1, 2, 3 Vinik B.S.... Fiedorek F.T. Jr. (Mamm. Genome 1995)
    2. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. (PubMed id 9808624)1, 2, 9 Xia Y.... Karin M. (Genes Dev. 1998)
    3. SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling. (PubMed id 12223491)1, 2, 9 Rui H.L.... Lin S.C. (J. Biol. Chem. 2002)
    4. Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determination. (PubMed id 21129722)1, 2 Pearlman A.... Ostrer H. (Am. J. Hum. Genet. 2010)
    5. FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women. (PubMed id 20554749)1, 4 Barnholtz-Sloan J.S....Millikan R.C. (Carcinogenesis 2010)
    6. Distribution of FGFR2, TNRC9, MAP3K1, LSP1, and 8q24 alleles in genetically enriched breast cancer patients versus elderly tumor-free women. (PubMed id 20417875)1, 4 Gorodnova T.V....Imyanitov E.N. (Cancer Genet. Cytogenet. 2010)
    7. Common genetic variants associated with breast cancer and mammographic density measures that predict disease. (PubMed id 20145138)1, 4 Odefrey F....Southey M.C. (Cancer Res. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Breast cancer susceptibility variants alter risks in familial disease. (PubMed id 19617217)1, 4 Latif A....Newman W.G. (J. Med. Genet. 2010)
    10. Performance of common genetic variants in breast-cancer risk models. (PubMed id 20237344)1, 4 Wacholder S....Hunter D.J. (N. Engl. J. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4214 HGNC: 6848 AceView: MAP3K1 Ensembl:ENSG00000095015 euGenes: HUgn4214
    ECgene: MAP3K1 Kegg: 4214 H-InvDB: MAP3K1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAP3K1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAP3K1 gene:
    Search GeneIP for patents involving MAP3K1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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