Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MAP2K7 Gene

Aliases for MAP2K7 Gene

  • Mitogen-Activated Protein Kinase Kinase 7 2 3 5
  • Stress-Activated Protein Kinase Kinase 4 3 4
  • C-Jun N-Terminal Kinase Kinase 2 3 4
  • JNK-Activating Kinase 2 3 4
  • MAP Kinase Kinase 7 3 4
  • MAPK/ERK Kinase 7 3 4
  • SAPK Kinase 4 3 4
  • EC 2.7.12.2 4 63
  • SAPKK-4 3 4
  • PRKMK7 3 4
  • SAPKK4 3 4
  • MEK 7 3 4
  • JNKK2 3 4
  • MKK7 3 4
  • JNK Kinase 2 4
  • MAPKK 7 4
  • MAPKK7 3
  • JNKK 2 4
  • MEK7 4
  • SKK4 4
  • MEK 3

External Ids for MAP2K7 Gene

Previous HGNC Symbols for MAP2K7 Gene

  • PRKMK7

Previous GeneCards Identifiers for MAP2K7 Gene

  • GC19P007927
  • GC19P008073
  • GC19P007863
  • GC19P007875
  • GC19P007876
  • GC19P007877
  • GC19P007968
  • GC19P007641

Summaries for MAP2K7 Gene

Entrez Gene Summary for MAP2K7 Gene

  • The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for MAP2K7 Gene

MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7) is a Protein Coding gene. Among its related pathways are RANK Signaling in Osteoclasts and Toll-Like receptor Signaling Pathways. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP2K2.

UniProtKB/Swiss-Prot for MAP2K7 Gene

  • Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

Gene Wiki entry for MAP2K7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP2K7 Gene

Genomics for MAP2K7 Gene

Regulatory Elements for MAP2K7 Gene

Enhancers for MAP2K7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAP2K7 on UCSC Golden Path with GeneCards custom track

Promoters for MAP2K7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAP2K7 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAP2K7 Gene

Chromosome:
19
Start:
7,903,780 bp from pter
End:
7,914,483 bp from pter
Size:
10,704 bases
Orientation:
Plus strand

Genomic View for MAP2K7 Gene

Genes around MAP2K7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP2K7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP2K7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP2K7 Gene

Proteins for MAP2K7 Gene

  • Protein details for MAP2K7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14733-MP2K7_HUMAN
    Recommended name:
    Dual specificity mitogen-activated protein kinase kinase 7
    Protein Accession:
    O14733
    Secondary Accessions:
    • B2R9S5
    • D6W659
    • O14648
    • O14816
    • O60452
    • O60453
    • Q1PG43
    • Q8IY10

    Protein attributes for MAP2K7 Gene

    Size:
    419 amino acids
    Molecular mass:
    47485 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with isoform 1 of VRK2. Interacts (via its D domain) with its substrates MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3 (By similarity). Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1 and MAP3K1/MEKK1 (By similarity). Interacts with MAPK8IP1/JIP1, MAPK8IP2/JIP2 and MAPK8IP3/JIP3 scaffold proteins. Interacts with RASSF7, the interaction promotes phosphorylation.
    SequenceCaution:
    • Sequence=AAB97813.1; Type=Erroneous termination; Positions=420; Note=Translated as stop.; Evidence={ECO:0000305}; Sequence=AAB97813.1; Type=Frameshift; Positions=402, 410; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAP2K7 Gene

    Alternative splice isoforms for MAP2K7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP2K7 Gene

Proteomics data for MAP2K7 Gene at MOPED

Selected DME Specific Peptides for MAP2K7 Gene

Post-translational modifications for MAP2K7 Gene

  • Activated by phosphorylation on Ser-271 and Thr-275 by MAP kinase kinase kinases (MAP3Ks).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP2K7 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAP2K7 (MKK7)
  • Cloud-Clone Corp. Antibodies for MAP2K7

Domains & Families for MAP2K7 Gene

Protein Domains for MAP2K7 Gene

Suggested Antigen Peptide Sequences for MAP2K7 Gene

Graphical View of Domain Structure for InterPro Entry

O14733

UniProtKB/Swiss-Prot:

MP2K7_HUMAN :
  • The DVD domain (residues 377-400) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Domain:
  • The DVD domain (residues 377-400) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation.
  • The D domain (residues 37-57) contains a conserved docking site and is required for the binding to MAPK substrates.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
genes like me logo Genes that share domains with MAP2K7: view

Function for MAP2K7 Gene

Molecular function for MAP2K7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK.
UniProtKB/Swiss-Prot Function:
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

Enzyme Numbers (IUBMB) for MAP2K7 Gene

Gene Ontology (GO) - Molecular Function for MAP2K7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 9535930
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with MAP2K7: view
genes like me logo Genes that share phenotypes with MAP2K7: view

Animal Models for MAP2K7 Gene

MGI Knock Outs for MAP2K7:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP2K7 Gene

Localization for MAP2K7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP2K7 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP2K7 Gene COMPARTMENTS Subcellular localization image for MAP2K7 gene
Compartment Confidence
cytosol 5
nucleus 5
golgi apparatus 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for MAP2K7 Gene

Pathways & Interactions for MAP2K7 Gene

SuperPathways for MAP2K7 Gene

Superpath Contained pathways
1 MyD88 cascade initiated on plasma membrane
2 Toll-Like receptor Signaling Pathways
3 4-1BB Pathway
4 TWEAK Pathway
5 RANK Signaling in Osteoclasts
genes like me logo Genes that share pathways with MAP2K7: view

SIGNOR curated interactions for MAP2K7 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for MAP2K7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with MAP2K7: view

Drugs & Compounds for MAP2K7 Gene

(12) Drugs for MAP2K7 Gene - From: DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
WX-554 Pharma inhibitor MEK inhibitor 0
Magnesium Nutra 0

(3) Additional Compounds for MAP2K7 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MAP2K7: view

Transcripts for MAP2K7 Gene

Unigene Clusters for MAP2K7 Gene

Mitogen-activated protein kinase kinase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K7 Gene

No ASD Table

Relevant External Links for MAP2K7 Gene

GeneLoc Exon Structure for
MAP2K7
ECgene alternative splicing isoforms for
MAP2K7

Expression for MAP2K7 Gene

mRNA expression in normal human tissues for MAP2K7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAP2K7 Gene

This gene is overexpressed in Urinary Bladder (12.0), Plasma (11.0), Prostate (9.1), and Retina (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP2K7 Gene



SOURCE GeneReport for Unigene cluster for MAP2K7 Gene Hs.531754

mRNA Expression by UniProt/SwissProt for MAP2K7 Gene

O14733-MP2K7_HUMAN
Tissue specificity: Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.
genes like me logo Genes that share expression patterns with MAP2K7: view

Protein tissue co-expression partners for MAP2K7 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for MAP2K7 Gene

Orthologs for MAP2K7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP2K7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAP2K7 35
  • 93.67 (n)
  • 99.47 (a)
MAP2K7 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP2K7 35
  • 93.24 (n)
  • 98.81 (a)
MAP2K7 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map2k7 35
  • 90.27 (n)
  • 98.56 (a)
Map2k7 16
Map2k7 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAP2K7 35
  • 99.44 (n)
  • 100 (a)
MAP2K7 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map2k7 35
  • 90.14 (n)
  • 99.05 (a)
oppossum
(Monodelphis domestica)
Mammalia MAP2K7 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP2K7 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP2K7 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map2k7 35
  • 75.54 (n)
  • 86.2 (a)
Str.69 35
African clawed frog
(Xenopus laevis)
Amphibia map2k7-A 35
zebrafish
(Danio rerio)
Actinopterygii map2k7 35
  • 73.54 (n)
  • 82.52 (a)
map2k7 36
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta hep 37
  • 66 (a)
hep 35
  • 65 (n)
  • 63.34 (a)
hep 36
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F35C8.1 37
  • 32 (a)
jkk-1 37
  • 36 (a)
mek-1 37
  • 50 (a)
mek-1 35
  • 58.91 (n)
  • 54.15 (a)
jkk-1 36
  • 36 (a)
OneToMany
mek-1 36
  • 50 (a)
OneToMany
sek-4 36
  • 30 (a)
OneToMany
sek-5 36
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBS2 36
  • 20 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4331 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToOne
Species with no ortholog for MAP2K7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP2K7 Gene

ENSEMBL:
Gene Tree for MAP2K7 (if available)
TreeFam:
Gene Tree for MAP2K7 (if available)

Paralogs for MAP2K7 Gene

Paralogs for MAP2K7 Gene

genes like me logo Genes that share paralogs with MAP2K7: view

Variants for MAP2K7 Gene

Sequence variations from dbSNP and Humsavar for MAP2K7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1053566 - 7,911,079(+) TCAAG(C/T)TCTGC reference, missense
rs56316660 - 7,910,279(+) AATCA(A/G)CGACC reference, missense
rs56106612 - 7,910,338(+) AGATG(C/T)GCTTC reference, missense
VAR_040827 A colorectal adenocarcinoma sample
VAR_040828 A colorectal adenocarcinoma sample

Structural Variations from Database of Genomic Variants (DGV) for MAP2K7 Gene

Variant ID Type Subtype PubMed ID
dgv3715n71 CNV Loss 21882294
nsv833733 CNV Gain 17160897
nsv910984 CNV Loss 21882294
dgv3716n71 CNV Loss 21882294
nsv910989 CNV Loss 21882294
nsv910990 CNV Loss 21882294
nsv828421 CNV Gain 20364138

Variation tolerance for MAP2K7 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP2K7 Gene

Human Gene Mutation Database (HGMD)
MAP2K7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP2K7 Gene

Disorders for MAP2K7 Gene

Relevant External Links for MAP2K7

Human Genome Epidemiology (HuGE) Navigator
MAP2K7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP2K7

No disorders were found for MAP2K7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP2K7 Gene

Publications for MAP2K7 Gene

  1. Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38. (PMID: 9312068) Lu X. … Lin A. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation. (PMID: 20156194) Nakagawa K. … Nishina H. (Biochem. J. 2010) 3 23
  3. Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases. (PMID: 18713996) Yoshizawa T. … Firestein G.S. (J. Immunol. 2008) 3 23
  4. The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway. (PMID: 17189706) Blonska M. … Lin X. (Immunity 2007) 3 23
  5. Cloning and expression of human mitogen-activated protein kinase kinase 7gamma1. (PMID: 16442502) Michael L. … Robinson M.J. (Biochem. Biophys. Res. Commun. 2006) 3 23

Products for MAP2K7 Gene

Sources for MAP2K7 Gene

Content