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Aliases for MAP2K7 Gene

Aliases for MAP2K7 Gene

  • Mitogen-Activated Protein Kinase Kinase 7 2 3
  • Stress-Activated Protein Kinase Kinase 4 3 4
  • C-Jun N-Terminal Kinase Kinase 2 3 4
  • JNK-Activating Kinase 2 3 4
  • MAP Kinase Kinase 7 3 4
  • MAPK/ERK Kinase 7 3 4
  • SAPK Kinase 4 3 4
  • EC 2.7.12.2 4 64
  • SAPKK-4 3 4
  • PRKMK7 3 4
  • SAPKK4 3 4
  • MEK 7 3 4
  • JNKK2 3 4
  • MKK7 3 4
  • Dual Specificity Mitogen-Activated Protein Kinase Kinase 7 3
  • JNK Kinase 2 4
  • MAPKK 7 4
  • MAPKK7 3
  • JNKK 2 4
  • MEK7 4
  • SKK4 4
  • MEK 3

External Ids for MAP2K7 Gene

Previous Symbols for MAP2K7 Gene

  • PRKMK7

Summaries for MAP2K7 Gene

Entrez Gene Summary for MAP2K7 Gene

  • The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for MAP2K7 Gene

MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7) is a Protein Coding gene. Among its related pathways are PI-3K cascade and MAPK signaling pathway. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is MAP2K2.

UniProtKB/Swiss-Prot for MAP2K7 Gene

  • Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

Gene Wiki entry for MAP2K7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP2K7 Gene

Genomics for MAP2K7 Gene

Genomic Location for MAP2K7 Gene

Start:
7,903,780 bp from pter
End:
7,914,478 bp from pter
Size:
10,699 bases
Orientation:
Plus strand

Genomic View for MAP2K7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP2K7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP2K7 Gene

Regulatory Elements for MAP2K7 Gene

Proteins for MAP2K7 Gene

  • Protein details for MAP2K7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14733-MP2K7_HUMAN
    Recommended name:
    Dual specificity mitogen-activated protein kinase kinase 7
    Protein Accession:
    O14733
    Secondary Accessions:
    • B2R9S5
    • D6W659
    • O14648
    • O14816
    • O60452
    • O60453
    • Q1PG43
    • Q8IY10

    Protein attributes for MAP2K7 Gene

    Size:
    419 amino acids
    Molecular mass:
    47485 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with isoform 1 of VRK2. Interacts (via its D domain) with its substrates MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3 (By similarity). Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1 and MAP3K1/MEKK1 (By similarity). Interacts with MAPK8IP1/JIP1, MAPK8IP2/JIP2 and MAPK8IP3/JIP3 scaffold proteins. Interacts with RASSF7, the interaction promotes phosphorylation.
    SequenceCaution:
    • Sequence=AAB97813.1; Type=Erroneous termination; Positions=420; Note=Translated as stop.; Evidence={ECO:0000305}; Sequence=AAB97813.1; Type=Frameshift; Positions=402, 410; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAP2K7 Gene

    Alternative splice isoforms for MAP2K7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP2K7 Gene

Proteomics data for MAP2K7 Gene at MOPED

Selected DME Specific Peptides for MAP2K7 Gene

Post-translational modifications for MAP2K7 Gene

  • Activated by phosphorylation on Ser-271 and Thr-275 by MAP kinase kinase kinases (MAP3Ks).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys9

Other Protein References for MAP2K7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for MAP2K7 Gene

Gene Families for MAP2K7 Gene

HGNC:
  • MAP2K :Mitogen-activated protein kinase cascade / Kinase kinases
IUPHAR :

Protein Domains for MAP2K7 Gene

UniProtKB/Swiss-Prot:

MP2K7_HUMAN
Domain:
  • The DVD domain (residues 377-400) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation.:
    • O14733
  • The D domain (residues 37-57) contains a conserved docking site and is required for the binding to MAPK substrates.:
    • O14733
  • Contains 1 protein kinase domain.:
    • O14733
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.:
    • O14733
genes like me logo Genes that share domains with MAP2K7: view

Function for MAP2K7 Gene

Molecular function for MAP2K7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK.
UniProtKB/Swiss-Prot Function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

Enzyme Numbers (IUBMB) for MAP2K7 Gene

Gene Ontology (GO) - Molecular Function for MAP2K7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 9535930
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004708 MAP kinase kinase activity IDA 9535930
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with MAP2K7: view
genes like me logo Genes that share phenotypes with MAP2K7: view

Animal Models for MAP2K7 Gene

MGI Knock Outs for MAP2K7:

miRNA for MAP2K7 Gene

miRTarBase miRNAs that target MAP2K7

No data available for Transcription Factor Targeting and HOMER Transcription for MAP2K7 Gene

Localization for MAP2K7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP2K7 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP2K7 Gene COMPARTMENTS Subcellular localization image for MAP2K7 gene
Compartment Confidence
nucleus 5
cytosol 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MAP2K7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAP2K7: view

Pathways for MAP2K7 Gene

genes like me logo Genes that share pathways with MAP2K7: view

Gene Ontology (GO) - Biological Process for MAP2K7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006468 protein phosphorylation --
genes like me logo Genes that share ontologies with MAP2K7: view

Compounds for MAP2K7 Gene

(3) HMDB Compounds for MAP2K7 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(11) Novoseek inferred chemical compound relationships for MAP2K7 Gene

Compound -log(P) Hits PubMed IDs
sp 600125 67.7 1
anisomycin 62.3 2
rottlerin 54.5 1
threonine 36.7 7
tyrosine 31.2 13
genes like me logo Genes that share compounds with MAP2K7: view

Transcripts for MAP2K7 Gene

Unigene Clusters for MAP2K7 Gene

Mitogen-activated protein kinase kinase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K7 Gene

No ASD Table

Relevant External Links for MAP2K7 Gene

GeneLoc Exon Structure for
MAP2K7
ECgene alternative splicing isoforms for
MAP2K7

Expression for MAP2K7 Gene

mRNA expression in normal human tissues for MAP2K7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP2K7 Gene

SOURCE GeneReport for Unigene cluster for MAP2K7 Gene Hs.531754

mRNA Expression by UniProt/SwissProt for MAP2K7 Gene

O14733-MP2K7_HUMAN
Tissue specificity: Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.
genes like me logo Genes that share expressions with MAP2K7: view

Orthologs for MAP2K7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP2K7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP2K7 36
  • 99.44 (n)
  • 100 (a)
MAP2K7 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAP2K7 36
  • 93.67 (n)
  • 99.47 (a)
MAP2K7 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP2K7 36
  • 93.24 (n)
  • 98.81 (a)
MAP2K7 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map2k7 36
  • 90.27 (n)
  • 98.56 (a)
Map2k7 16
Map2k7 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP2K7 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP2K7 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map2k7 36
  • 90.14 (n)
  • 99.05 (a)
lizard
(Anolis carolinensis)
Reptilia MAP2K7 37
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia map2k7-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia map2k7 36
  • 75.54 (n)
  • 86.2 (a)
Str.69 36
zebrafish
(Danio rerio)
Actinopterygii map2k7 36
  • 73.54 (n)
  • 82.52 (a)
map2k7 37
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta hep 36
  • 65 (n)
  • 63.34 (a)
hep 37
  • 21 (a)
OneToOne
hep 38
  • 66 (a)
worm
(Caenorhabditis elegans)
Secernentea jkk-1 37
  • 36 (a)
OneToMany
mek-1 36
  • 58.91 (n)
  • 54.15 (a)
mek-1 37
  • 50 (a)
OneToMany
sek-4 37
  • 30 (a)
OneToMany
sek-5 37
  • 29 (a)
OneToMany
F35C8.1 38
  • 32 (a)
mek-1 38
  • 50 (a)
jkk-1 38
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBS2 37
  • 20 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4331 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 51 (a)
OneToOne
Species with no ortholog for MAP2K7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP2K7 Gene

ENSEMBL:
Gene Tree for MAP2K7 (if available)
TreeFam:
Gene Tree for MAP2K7 (if available)

Paralogs for MAP2K7 Gene

Paralogs for MAP2K7 Gene

genes like me logo Genes that share paralogs with MAP2K7: view

Variants for MAP2K7 Gene

Sequence variations from dbSNP and Humsavar for MAP2K7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3679 -- 7,913,545(-) TGACC(A/G)CCTCG utr-variant-3-prime
rs480296 -- 7,911,742(-) CTCCC(C/T)GGGCA intron-variant
rs794452 -- 7,907,095(-) cgcga(A/T)ctcag intron-variant
rs1053566 - 7,911,079(+) TCAAG(C/T)TCTGC reference, missense
rs1053579 -- 7,913,752(+) aaaaa(A/T)aacaa utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MAP2K7 Gene

Variant ID Type Subtype PubMed ID
dgv3715n71 CNV Loss 21882294
nsv833733 CNV Gain 17160897
nsv910984 CNV Loss 21882294
dgv3716n71 CNV Loss 21882294
nsv910989 CNV Loss 21882294
nsv910990 CNV Loss 21882294
nsv828421 CNV Gain 20364138

Relevant External Links for MAP2K7 Gene

HapMap Linkage Disequilibrium report
MAP2K7
Human Gene Mutation Database (HGMD)
MAP2K7

Disorders for MAP2K7 Gene

(7) Novoseek inferred disease relationships for MAP2K7 Gene

Disease -log(P) Hits PubMed IDs
necrosis 31.2 4
prostate cancer 15.1 4
rheumatoid arthritis 13 1
tumors 9.93 8
insulin resistance 0 1

Relevant External Links for MAP2K7

Human Genome Epidemiology (HuGE) Navigator
MAP2K7
genes like me logo Genes that share disorders with MAP2K7: view

No data available for UniProtKB/Swiss-Prot for MAP2K7 Gene

Publications for MAP2K7 Gene

  1. Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38. (PMID: 9312068) Lu X. … Lin A. (J. Biol. Chem. 1997) 2 3 4 23
  2. The JIP group of mitogen-activated protein kinase scaffold proteins. (PMID: 10490659) Yasuda J. … Davis R.J. (Mol. Cell. Biol. 1999) 3 4 23
  3. Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli. (PMID: 9535930) Foltz I.N. … Schrader J.W. (J. Biol. Chem. 1998) 3 4 23
  4. Cloning and expression of human mitogen-activated protein kinase kinase 7gamma1. (PMID: 16442502) Michael L. … Robinson M.J. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  5. Mitogen-activated protein kinase kinase 7 is an activator of the c- Jun NH2-terminal kinase. (PMID: 9207092) Tournier C. … Davis R.J. (Proc. Natl. Acad. Sci. U.S.A. 1997) 3 4 23

Products for MAP2K7 Gene

Sources for MAP2K7 Gene

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