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Aliases for MAP2K7 Gene

Aliases for MAP2K7 Gene

  • Mitogen-Activated Protein Kinase Kinase 7 2 3 5
  • Stress-Activated Protein Kinase Kinase 4 3 4
  • C-Jun N-Terminal Kinase Kinase 2 3 4
  • JNK-Activating Kinase 2 3 4
  • MAP Kinase Kinase 7 3 4
  • MAPK/ERK Kinase 7 3 4
  • SAPK Kinase 4 3 4
  • EC 2.7.12.2 4 58
  • SAPKK-4 3 4
  • PRKMK7 3 4
  • SAPKK4 3 4
  • MEK 7 3 4
  • JNKK2 3 4
  • MKK7 3 4
  • Dual Specificity Mitogen-Activated Protein Kinase Kinase 7 3
  • JNK Kinase 2 4
  • MAPKK 7 4
  • MAPKK7 3
  • JNKK 2 4
  • MEK7 4
  • SKK4 4
  • MEK 3

External Ids for MAP2K7 Gene

Previous HGNC Symbols for MAP2K7 Gene

  • PRKMK7

Previous GeneCards Identifiers for MAP2K7 Gene

  • GC19P007927
  • GC19P008073
  • GC19P007863
  • GC19P007875
  • GC19P007876
  • GC19P007877
  • GC19P007968
  • GC19P007641

Summaries for MAP2K7 Gene

Entrez Gene Summary for MAP2K7 Gene

  • The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

CIViC summary for MAP2K7 Gene

GeneCards Summary for MAP2K7 Gene

MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7) is a Protein Coding gene. Diseases associated with MAP2K7 include Acneiform Dermatitis and Refractory Hematologic Cancer. Among its related pathways are 4-1BB Pathway and Activated TLR4 signalling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP2K4.

UniProtKB/Swiss-Prot for MAP2K7 Gene

  • Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

Gene Wiki entry for MAP2K7 Gene

Additional gene information for MAP2K7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP2K7 Gene

Genomics for MAP2K7 Gene

Regulatory Elements for MAP2K7 Gene

Enhancers for MAP2K7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H007196 2 FANTOM5 Ensembl ENCODE dbSUPER 30.3 -705.1 -705088 4 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ELAVL1 XAB2 ZNF557 KHSRP MAP2K7 GTF2F1 ARHGEF18 PSPN GPR108 INSR
GH19H007177 1.5 Ensembl ENCODE dbSUPER 36.1 -722.7 -722706 7 HDGF PKNOX1 FEZF1 ZNF121 ZNF302 ZNF143 ZNF207 ATF7 RUNX3 ZNF202 ELAVL1 XAB2 KHSRP ZNF557 MAP2K7 GTF2F1 DENND1C ARHGEF18 GPR108 EVI5L
GH19H008388 1.7 Ensembl ENCODE dbSUPER 28.8 +489.1 489065 10 MLX YY1 ZNF143 ZNF548 SP3 NFYC ZC3H11A GLIS1 RCOR2 NBN HNRNPM ELAVL1 ZNF699 ZNF558 XAB2 ZNF317 MAP2K7 ENSG00000269300 MARCH2 LINC01862
GH19H008319 1.1 ENCODE 30.9 +417.7 417676 3 HDGF HNRNPUL1 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 RPS28 HNRNPM XAB2 ZNF317 ZNF699 ZNF558 MAP2K7 ELAVL1 ZNF414 CD320
GH19H007521 1.7 FANTOM5 ENCODE dbSUPER 19 -380.9 -380923 2 HDGF MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 HNRNPM ELAVL1 XAB2 ZNF557 ZNF414 MAP2K7 TIMM44 SNAPC2 CD209 EVI5L
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAP2K7 on UCSC Golden Path with GeneCards custom track

Promoters for MAP2K7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000106745 20 1601 HDGF PKNOX1 MLX SIN3A ARID4B DMAP1 ZNF2 YY1 ZNF143 FOS

Genomic Location for MAP2K7 Gene

Chromosome:
19
Start:
7,903,780 bp from pter
End:
7,914,483 bp from pter
Size:
10,704 bases
Orientation:
Plus strand

Genomic View for MAP2K7 Gene

Genes around MAP2K7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP2K7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP2K7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP2K7 Gene

Proteins for MAP2K7 Gene

  • Protein details for MAP2K7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14733-MP2K7_HUMAN
    Recommended name:
    Dual specificity mitogen-activated protein kinase kinase 7
    Protein Accession:
    O14733
    Secondary Accessions:
    • B2R9S5
    • D6W659
    • O14648
    • O14816
    • O60452
    • O60453
    • Q1PG43
    • Q8IY10

    Protein attributes for MAP2K7 Gene

    Size:
    419 amino acids
    Molecular mass:
    47485 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with isoform 1 of VRK2. Interacts (via its D domain) with its substrates MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3 (By similarity). Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1 and MAP3K1/MEKK1 (By similarity). Interacts with MAPK8IP1/JIP1, MAPK8IP2/JIP2 and MAPK8IP3/JIP3 scaffold proteins. Interacts with RASSF7, the interaction promotes phosphorylation.
    SequenceCaution:
    • Sequence=AAB97813.1; Type=Erroneous termination; Positions=420; Note=Translated as stop.; Evidence={ECO:0000305}; Sequence=AAB97813.1; Type=Frameshift; Positions=402, 410; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAP2K7 Gene

    Alternative splice isoforms for MAP2K7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP2K7 Gene

Selected DME Specific Peptides for MAP2K7 Gene

O14733:
  • YDIRADVWSLGI
  • TDFEVLTKVL
  • IKLCDFGISG
  • TRSAGCAAYMAPERIDP
  • EENKRILMDLDVVLKSHDC

Post-translational modifications for MAP2K7 Gene

  • Activated by phosphorylation on Ser-271 and Thr-275 by MAP kinase kinase kinases (MAP3Ks).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP2K7 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAP2K7 (MKK7)
  • Cloud-Clone Corp. Antibodies for MAP2K7
  • Santa Cruz Biotechnology (SCBT) Antibodies for MAP2K7

Domains & Families for MAP2K7 Gene

Gene Families for MAP2K7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MAP2K7 Gene

Suggested Antigen Peptide Sequences for MAP2K7 Gene

Graphical View of Domain Structure for InterPro Entry

O14733

UniProtKB/Swiss-Prot:

MP2K7_HUMAN :
  • The DVD domain (residues 377-400) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Domain:
  • The DVD domain (residues 377-400) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation.
  • The D domain (residues 37-57) contains a conserved docking site and is required for the binding to MAPK substrates.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
genes like me logo Genes that share domains with MAP2K7: view

Function for MAP2K7 Gene

Molecular function for MAP2K7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK.
UniProtKB/Swiss-Prot Function:
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

Enzyme Numbers (IUBMB) for MAP2K7 Gene

Phenotypes From GWAS Catalog for MAP2K7 Gene

Gene Ontology (GO) - Molecular Function for MAP2K7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 9535930
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0004708 MAP kinase kinase activity IDA 9535930
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with MAP2K7: view
genes like me logo Genes that share phenotypes with MAP2K7: view

Animal Models for MAP2K7 Gene

MGI Knock Outs for MAP2K7:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MAP2K7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP2K7 Gene

Localization for MAP2K7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP2K7 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP2K7 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
extracellular 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
golgi apparatus 2
peroxisome 1
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAP2K7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IBA,ISS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAP2K7: view

Pathways & Interactions for MAP2K7 Gene

SuperPathways for MAP2K7 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 Toll-Like receptor Signaling Pathways
3 TNFR1 Pathway
4 4-1BB Pathway
5 RANK Signaling in Osteoclasts
genes like me logo Genes that share pathways with MAP2K7: view

Pathways by source for MAP2K7 Gene

SIGNOR curated interactions for MAP2K7 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for MAP2K7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process IEA --
GO:0006970 response to osmotic stress IDA 9535930
GO:0007165 signal transduction TAS 9535930
GO:0007254 JNK cascade TAS --
genes like me logo Genes that share ontologies with MAP2K7: view

Drugs & Compounds for MAP2K7 Gene

(12) Drugs for MAP2K7 Gene - From: DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
WX-554 Pharma inhibitor MEK inhibitor 0
ATP Nutra Agonist 0
Magnesium Nutra 0

(3) Additional Compounds for MAP2K7 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MAP2K7: view

Transcripts for MAP2K7 Gene

Unigene Clusters for MAP2K7 Gene

Mitogen-activated protein kinase kinase 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MAP2K7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K7 Gene

No ASD Table

Relevant External Links for MAP2K7 Gene

GeneLoc Exon Structure for
MAP2K7
ECgene alternative splicing isoforms for
MAP2K7

Expression for MAP2K7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP2K7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAP2K7 Gene

This gene is overexpressed in Urinary Bladder (12.0), Plasma (11.0), Prostate (9.1), and Retina (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP2K7 Gene



Protein tissue co-expression partners for MAP2K7 Gene

NURSA nuclear receptor signaling pathways regulating expression of MAP2K7 Gene:

MAP2K7

SOURCE GeneReport for Unigene cluster for MAP2K7 Gene:

Hs.531754

mRNA Expression by UniProt/SwissProt for MAP2K7 Gene:

O14733-MP2K7_HUMAN
Tissue specificity: Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.

Evidence on tissue expression from TISSUES for MAP2K7 Gene

  • Muscle(4.6)
  • Nervous system(4.6)
  • Heart(4.5)
  • Lung(2.9)
  • Blood(2.8)
  • Intestine(2.8)
  • Skin(2.8)
  • Adrenal gland(2.6)
  • Kidney(2.6)
  • Bone marrow(2.5)
  • Liver(2.5)
  • Eye(2.2)
  • Pancreas(2.2)
  • Thyroid gland(2.2)
  • Lymph node(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with MAP2K7: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP2K7 Gene

Orthologs for MAP2K7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP2K7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP2K7 33 34
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia MAP2K7 33 34
  • 93.67 (n)
dog
(Canis familiaris)
Mammalia MAP2K7 33 34
  • 93.24 (n)
oppossum
(Monodelphis domestica)
Mammalia MAP2K7 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map2k7 33 16 34
  • 90.27 (n)
rat
(Rattus norvegicus)
Mammalia Map2k7 33
  • 90.14 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAP2K7 34
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP2K7 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map2k7 33
  • 75.54 (n)
Str.69 33
African clawed frog
(Xenopus laevis)
Amphibia map2k7-A 33
zebrafish
(Danio rerio)
Actinopterygii map2k7 33 34
  • 73.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta hep 35 33 34
  • 65 (n)
worm
(Caenorhabditis elegans)
Secernentea mek-1 35 33 34
  • 58.91 (n)
jkk-1 35 34
  • 36 (a)
F35C8.1 35
  • 32 (a)
sek-4 34
  • 30 (a)
OneToMany
sek-5 34
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBS2 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4331 33
Species where no ortholog for MAP2K7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP2K7 Gene

ENSEMBL:
Gene Tree for MAP2K7 (if available)
TreeFam:
Gene Tree for MAP2K7 (if available)

Paralogs for MAP2K7 Gene

Paralogs for MAP2K7 Gene

genes like me logo Genes that share paralogs with MAP2K7: view

Variants for MAP2K7 Gene

Sequence variations from dbSNP and Humsavar for MAP2K7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_040827 A colorectal adenocarcinoma sample
VAR_040828 A colorectal adenocarcinoma sample
rs1000082187 -- 7,913,169(+) GTTGT(C/G/T)GGTAC utr-variant-3-prime
rs1000158066 -- 7,913,408(+) GGGAA(C/T)CGGTG upstream-variant-2KB, utr-variant-3-prime
rs1000202521 -- 7,905,362(+) TCAGC(A/G)TGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP2K7 Gene

Variant ID Type Subtype PubMed ID
nsv828421 CNV gain 20364138
nsv833733 CNV gain 17160897
nsv953961 CNV deletion 24416366

Variation tolerance for MAP2K7 Gene

Residual Variation Intolerance Score: 12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP2K7 Gene

Human Gene Mutation Database (HGMD)
MAP2K7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP2K7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP2K7 Gene

Disorders for MAP2K7 Gene

MalaCards: The human disease database

(16) MalaCards diseases for MAP2K7 Gene - From: HGMD and DISEASES

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAP2K7

Human Genome Epidemiology (HuGE) Navigator
MAP2K7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP2K7
genes like me logo Genes that share disorders with MAP2K7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP2K7 Gene

Publications for MAP2K7 Gene

  1. Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38. (PMID: 9312068) Lu X … Lin A (The Journal of biological chemistry 1997) 2 3 4 22 60
  2. Cloning and expression of human mitogen-activated protein kinase kinase 7gamma1. (PMID: 16442502) Michael L … Robinson MJ (Biochemical and biophysical research communications 2006) 3 4 22 60
  3. The JIP group of mitogen-activated protein kinase scaffold proteins. (PMID: 10490659) Yasuda J … Davis RJ (Molecular and cellular biology 1999) 3 4 22 60
  4. Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli. (PMID: 9535930) Foltz IN … Schrader JW (The Journal of biological chemistry 1998) 3 4 22 60
  5. Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. (PMID: 9207092) Tournier C … Davis RJ (Proceedings of the National Academy of Sciences of the United States of America 1997) 3 4 22 60

Products for MAP2K7 Gene

Sources for MAP2K7 Gene

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