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MAP2K7 Gene

protein-coding   GIFtS: 69
GCID: GC19P007968

Mitogen-Activated Protein Kinase Kinase 7


(Previous symbol: PRKMK7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase Kinase 71 2     MAPKK 72 3
PRKMK71 2 3     MEK 72 3
Stress-Activated Protein Kinase Kinase 42 3     SAPK Kinase 42 3
MKK72 3     EC 2.7.12.23 8
SAPKK-42 3     Jnkk22
SAPKK42 3     MAPKK72
C-Jun N-Terminal Kinase Kinase 22 3     Dual Specificity Mitogen-Activated Protein Kinase Kinase 72
JNK-Activating Kinase 22 3     JNKK23
JNKK 22 3     MEK73
MAP Kinase Kinase 72 3     SKK43
MAPK/ERK Kinase 72 3     JNK Kinase 23

External Ids:    HGNC: 68471   Entrez Gene: 56092   Ensembl: ENSG000000769847   OMIM: 6030145   UniProtKB: O147333   

Export aliases for MAP2K7 gene to outside databases

Previous GC identifers: GC19P007927 GC19P008073 GC19P007863 GC19P007875 GC19P007876 GC19P007877 GC19P007641


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP2K7 Gene:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase
family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated
and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK.
This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and
environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been
found, but only one transcript variant has been supported and defined. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAP2K7 Gene:
MAP2K7 (mitogen-activated protein kinase kinase 7) is a protein-coding gene. Diseases associated with MAP2K7 include ovarian endometriosis, and hypertrophic scars. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is MAP2K3.

UniProtKB/Swiss-Prot: MP2K7_HUMAN, O14733
Function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal
transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase
(SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the
stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and
MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the
phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr
residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to
increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional
phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK
signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also
involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis

Gene Wiki entry for MAP2K7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP2K7 gene promoter:
         c-Fos   GR   AP-1   ATF-2   GR-alpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP2K7 promoter sequence
   Search Chromatin IP Primers for MAP2K7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP2K7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3-p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.3-p13.2

MAP2K7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP2K7 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P007968:  view genomic region     (about GC identifiers)

Start:
7,968,728 bp from pter      End:
7,979,363 bp from pter
Size:
10,636 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MP2K7_HUMAN, O14733 (See protein sequence)
Recommended Name: Dual specificity mitogen-activated protein kinase kinase 7  
Size: 419 amino acids; 47485 Da
Cofactor: Magnesium
Subunit: Interacts with isoform 1 of VRK2. Interacts (via its D domain) with its substrates MAPK8/JNK1, MAPK9/JNK2
and MAPK10/JNK3 (By similarity). Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1 and
MAP3K1/MEKK1 (By similarity). Interacts with MAPK8IP1/JIP1, MAPK8IP2/JIP2 and MAPK8IP3/JIP3 scaffold proteins.
Interacts with RASSF7, the interaction promotes phosphorylation
Sequence caution: Sequence=AAB97813.1; Type=Erroneous termination; Positions=420; Note=Translated as stop;
Sequence=AAB97813.1; Type=Frameshift; Positions=402, 410;
1 PDB 3D structure from and Proteopedia for MAP2K7:
2DYL (3D)    
Secondary accessions: B2R9S5 D6W659 O14648 O14816 O60452 O60453 Q1PG43 Q8IY10
Alternative splicing: 4 isoforms:  O14733-1   O14733-2   O14733-3   O14733-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP2K7: NX_O14733

Explore proteomics data for MAP2K7 at MOPED

Post-translational modifications: 

  • Activated by phosphorylation on Ser-271 and Thr-275 by MAP kinase kinase kinases (MAP3Ks) (By similarity)1
  • Ubiquitination2 at Lys9
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAP2K7 (O14733) (see all 5)
     TDFEVLTKVL  IKLCDFGISG  YDIRADVWSLGI  TRSAGCAAYMAPERIDP 


    See MAP2K7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_660186.1  
    ENSEMBL proteins: 
     ENSP00000381068   ENSP00000381070   ENSP00000381066   ENSP00000443946  
    Reactome Protein details: O14733

    MAP2K7 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MAP2K7 Protein
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for MAP2K7
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    OriGene Custom Protein Services for MAP2K7
    GenScript Custom Purified and Recombinant Proteins Services for MAP2K7
    Novus Biologicals MAP2K7 Proteins
    Novus Biologicals MAP2K7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAP2K7

    MAP2K7 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP2K7
    R&D Systems Antibodies for MAP2K7 (MKK7)
    Cell Signaling Technology (CST) Antibodies for MAP2K7  (MKK7)
    OriGene Antibodies for MAP2K7
    OriGene Custom Antibody Services for MAP2K7
    Novus Biologicals MAP2K7 Antibodies
    Abcam antibodies for MAP2K7
    Cloud-Clone Corp. Antibodies for MAP2K7
    ThermoFisher Antibody for MAP2K7
    LSBio Antibodies in human, mouse, rat for MAP2K7

    MAP2K7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAP2K7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAP2K7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAP2K7
    Cloud-Clone Corp. CLIAs for MAP2K7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAP2K: Mitogen-activated protein kinase cascade / Kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase 7
    STE7 family

    4 InterPro protein domains:
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry O14733

    ProtoNet protein and cluster: O14733

    UniProtKB/Swiss-Prot: MP2K7_HUMAN, O14733
    Domain: The DVD domain (residues 377-400) contains a conserved docking site and is found in the mammalian MAP
    kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are
    essential for activation
    Domain: The D domain (residues 37-57) contains a conserved docking site and is required for the binding to MAPK
    substrates
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain


    MAP2K7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MP2K7_HUMAN, O14733
    Function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal
    transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase
    (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the
    stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and
    MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the
    phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr
    residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to
    increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional
    phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK
    signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also
    involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1,
    MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK

         Enzyme Number (IUBMB): EC 2.7.12.21 2

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA9535930
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004708MAP kinase kinase activity IDA9535930
    GO:0004713protein tyrosine kinase activity IEA--
         
    MAP2K7 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for MAP2K7:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased substrate adherent c 
     Increased viability after born  Increased viability with 4OH t 

         12 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Map2k7):
     behavior/neurological  cellular  endocrine/exocrine gland  homeostasis/metabolism  integument 
     mortality/aging  nervous system  normal  other  reproductive system 
     tumorigenesis  vision/eye 

    MAP2K7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MAP2K7: Map2k7tm2.1Rjd Map2k7tm1Pngr Map2k7tm1Flv

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAP2K7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAP2K7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP2K7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP2K7

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAP2K7:
    hsa-mir-125a-5p (MIRT045769)

    Block miRNA regulation of human, mouse, rat MAP2K7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP2K7 (see all 37):
    hsa-miR-328 hsa-miR-513a-5p hsa-miR-200a hsa-miR-128 hsa-miR-141 hsa-miR-9 hsa-miR-3909 hsa-miR-626
    SwitchGear 3'UTR luciferase reporter plasmidMAP2K7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAP2K7
    Predesigned siRNA for gene silencing in human, mouse, rat MAP2K7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAP2K7

    Clone
    Products:
         
    OriGene clones in human, mouse for MAP2K7 (see all 8)
    OriGene ORF clones in mouse, rat for MAP2K7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAP2K7 (NM_145185)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP2K7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP2K7

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MAP2K7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2K7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MP2K7_HUMAN, O14733: Nucleus. Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--

    MAP2K7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP2K7 About   (see all 59)  
    See pathways by source

    SuperPathContained pathways About
    1TWEAK Pathway
    Apoptosis and survival TNFR1 signaling pathway0.52
    Apoptotic Pathways Triggered By HIV10.42
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    Apoptosis through Death Receptors0.42
    2ErbB signaling pathway
    ErbB signaling pathway0.52
    EGFR Inhibitor Pathway, Pharmacodynamics0.49
    ErbB signaling pathway0.52
    3Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    Fc-epsilon receptor I signaling in mast cells0.34
    Fc epsilon RI signaling pathway0.41
    4NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    IL-1 Family Signaling Pathways0.44
    NOD-like Receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    Inflammasome Activation Pathways0.51
    5Development EGFR signaling pathway
    Development EGFR signaling pathway0.57
    GDNF-Family Ligands and Receptor Interactions0.41
    Development GDNF family signaling0.45
    EGF Pathway0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 R&D Systems Pathways for MAP2K7
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-1 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAP2K7 (see all 39)
        Toll-Like Receptors Pathway
    Molecular Mechanisms of Cancer
    G12-G13 in Cellular Signaling
    JNK Pathway
    PACAP Signaling

    1 Cell Signaling Technology (CST) Pathway for MAP2K7
        MAP Kinase Signaling

    Selected GeneGo (Thomson Reuters) Pathways for MAP2K7 (see all 15)
        Development A2A receptor signaling
    Development EGFR signaling pathway
    Development EGFR signaling via small GTPases
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Immune response CD28 signaling

    Selected BioSystems Pathways for MAP2K7 (see all 18)
        MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    EGFR1 Signaling Pathway
    Insulin Signaling
    ErbB signaling pathway

    3 Reactome Pathways for MAP2K7
        Oxidative Stress Induced Senescence
    JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
    FCERI mediated MAPK activation

    3 PharmGKB Pathways for MAP2K7
        EGFR Inhibitor Pathway, Pharmacodynamics
    Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for MAP2K7) (see all 12):
        MAPK signaling pathway
    ErbB signaling pathway
    Protein processing in endoplasmic reticulum
    Osteoclast differentiation
    Toll-like receptor signaling pathway


    MAP2K7 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP2K7: 
              EGF / PDGF Signaling Pathway in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAP2K7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAP2K7 (O147331, 2, 3 ENSP000003810664) via UniProtKB, MINT, STRING, and/or I2D (see all 899)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K7O433181, 2, 3, ENSP000003583354EBI-492605,EBI-358684 MINT-3391633 I2D: score=2 STRING: ENSP00000358335
    MAP3K5Q996832, 3, ENSP000003519084MINT-3391607 I2D: score=4 STRING: ENSP00000351908
    MAP3K1Q132332, 3, ENSP000003824234MINT-3391558 I2D: score=3 STRING: ENSP00000382423
    EXOC7Q9UPT52, 3MINT-7945693 MINT-7947479 I2D: score=2 
    MAD1L1Q9Y6D92, 3MINT-7945693 MINT-7947479 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation ----
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006468protein phosphorylation ----

    MAP2K7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAP2K7 (MP2K7)

    3 HMDB Compounds for MAP2K7    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Selected Novoseek inferred chemical compound relationships for MAP2K7 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sp 600125 67.7 1 15334063 (1)
    anisomycin 62.3 3 9535930 (1), 16802349 (1)
    rottlerin 54.5 1 11314034 (1)
    threonine 36.7 7 20156194 (2), 11062067 (2), 9516438 (1), 16442502 (1) (see all 5)
    tyrosine 31.2 14 11062067 (3), 20156194 (2), 9890951 (2), 10713072 (1) (see all 9)
    leucine 16.5 2 11163770 (1), 14699111 (1)
    phosphatidylinositol 6.73 1 12458207 (1)
    serine 0 1 9516438 (1)
    cysteine 0 1 17194451 (1)
    h2o2 0 2 11739664 (1)



    MAP2K7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAP2K7 gene: 
    NM_145185.2  

    Unigene Cluster for MAP2K7:

    Mitogen-activated protein kinase kinase 7
    Hs.531754  [show with all ESTs]
    Unigene Representative Sequence: BC038295
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397981(uc002miv.2 uc002mit.3 uc010xkb.2) ENST00000468058
    ENST00000397983(uc010xka.1) ENST00000397979 ENST00000475022(uc002mis.1)
    ENST00000494348 ENST00000465324 ENST00000498118 ENST00000545011(uc010dvv.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MAP2K7 (see all 37):
    hsa-miR-328 hsa-miR-513a-5p hsa-miR-200a hsa-miR-128 hsa-miR-141 hsa-miR-9 hsa-miR-3909 hsa-miR-626
    SwitchGear 3'UTR luciferase reporter plasmidMAP2K7 3' UTR sequence
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAP2K7 (NM_145185)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP2K7
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat MAP2K7
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    Additional mRNA sequence: 

    AF003199.1 AF006689.1 AF013588.1 AF013589.1 AF014401.1 AF022805.1 AK098807.1 AK300988.1 
    AK313899.1 BC038295.2 DQ445915.1 

    9 DOTS entries:

    DT.115150  DT.95189684  DT.40131374  DT.40274163  DT.40277306  DT.92416055  DT.92423473  DT.91743731 
    DT.95188601 

    Selected AceView cDNA sequences (see all 190):

    AA830118 BX114550 NM_145185 BM552815 BQ632196 BU579751 AI150003 BU732917 
    AF003199 CN485172 BM504596 BM711246 AA864681 AI150666 AA767564 AI767722 
    BE646371 CB155335 AA768834 AI280121 AK098807 CR604614 BQ631901 AW182784 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAP2K7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGGTCCCA
    MAP2K7 Expression
    About this image


    MAP2K7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Hippocampus
    MAP2K7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP2K7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531754

    UniProtKB/Swiss-Prot: MP2K7_HUMAN, O14733
    Tissue specificity: Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low
    levels in placenta, fetal liver, and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP2K7: 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2K7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAP2K7 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map2k71 , 5 mitogen-activated protein kinase kinase 71, 5 90.27(n)1
    98.56(a)1
      8 (1.99 cM)5
    264001  NM_001042557.21  NP_001036022.11 
     42387405 
    lizard
    (Anolis carolinensis)
    Reptilia MAP2K76
    mitogen-activated protein kinase kinase 7
    74(a)
    1 ↔ 1
    2(119618495-119659686)
    African clawed frog
    (Xenopus laevis)
    Amphibia map2k7-A2 mitogen-activated protein kinase kinase 7 78.89(n)    AB074001.1 
    zebrafish
    (Danio rerio)
    Actinopterygii map2k71 mitogen-activated protein kinase kinase 7 73.54(n)
    82.52(a)
      560913  NM_001190306.1  NP_001177235.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta hep1 , 3 dorsal appendage formation protein
    kinase3
    hemipterous1
    66(a)3
    65(n)1
    63.34(a)1
      1 11D103
    322561  NM_078587.21  NP_511142.21 
    worm
    (Caenorhabditis elegans)
    Secernentea mek-11 , 3 Expression: ventral ganglia, anus, ring
    neurons, more3
    mek-11
    50(a)
    (best of 3)3
    58.91(n)1
    54.15(a)1
      X(7514507-7517502)3
    1810041  NM_001029600.41  NP_001024771.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PBS26
    MAP kinase kinase of the HOG signaling pathway; ac...
    20(a)
    1 → many
    X(178097-180103) YJL128C


    ENSEMBL Gene Tree for MAP2K7 (if available)
    TreeFam Gene Tree for MAP2K7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP2K7 gene
    MAP2K32  MAP2K52  MAP2K22  MAP2K62  MAP2K42  MAP2K12  
    Selected SIMAP similar genes for MAP2K7 using alignment to 3 protein entries:     MP2K7_HUMAN (see all proteins) (see all similar genes):
    DKFZp686N0154    MAP2K3    MAP2K6    MAP2K4    MAP2K5    PAK4
    STK25    STK24    CCRK    MYO3A    STK3    MARK4
    MYO3B    NEK6    STK11    TNIK    MAP2K1    MAP4K4

    MAP2K7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP2K7 (see all 382)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0408284
    A colorectal adenocarcinoma sample4--see VAR_0408282 R H mis40--------
    VAR_0408274
    A colorectal adenocarcinoma sample4--see VAR_0408272 R C mis40--------
    rs1478247871,2
    --7905866(+) GACTTC/TGGTCT 1 -- us2k10--------
    rs1890203451,2
    --7905882(+) GTTCTC/TTGGGT 1 -- us2k10--------
    rs1918817091,2
    --7905931(+) GATCTC/TTTATG 1 -- us2k10--------
    rs561917251,2
    C,F--7906006(+) CCAGCG/ACTTTG 1 -- us2k13Minor allele frequency- A:0.24NA 124
    rs1841159061,2
    --7906020(+) GGCTCA/TGGTGG 1 -- us2k10--------
    rs20469211,2
    C,F,H--7906254(+) aacaaG/Caccct 1 -- us2k17Minor allele frequency- C:0.05NS EA NA 542
    rs1413954551,2
    --7906438(+) TTTTCA/GTATTT 1 -- us2k10--------
    rs1470138321,2
    --7906531(+) GCTGGG/TATTAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAP2K7 (7968728 - 7979363 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MAP2K7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv910984CNV Loss21882294
    dgv3716n71CNV Loss21882294
    nsv910990CNV Loss21882294
    nsv910989CNV Loss21882294
    dgv3715n71CNV Loss21882294
    nsv828421CNV Gain20364138
    nsv833733CNV Gain17160897

    Human Gene Mutation Database (HGMD): MAP2K7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP2K7
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP2K7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603014    OMIM disorders: --

    Selected diseases for MAP2K7 (see all 32):    
    About MalaCards
    ovarian endometriosis    hypertrophic scars    familial colorectal cancer    pharyngitis
    endometriosis    prostate cancer    insulin resistance    vaccinia
    influenza    rheumatoid arthritis    prostatitis    arthritis
    hepatitis c virus    cervical cancer    colorectal cancer    parkinson's disease
    ischemia    hepatitis c    cervicitis    cerebritis


    MAP2K7 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for MAP2K7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 31.2 4 9384583 (1), 9535930 (1), 17440097 (1), 19888449 (1)
    prostate cancer 15.1 4 17577251 (4)
    rheumatoid arthritis 13 1 13130464 (1)
    tumors 9.93 9 17577251 (2), 17440097 (2), 18834404 (1), 19888449 (1) (see all 6)
    insulin resistance 0 1 12554784 (1)
    shock 0 1 16815388 (1)
    metastasis 0 3 16322247 (2), 16489030 (1)

    Human Genome Epidemiology (HuGE) Navigator: MAP2K7 (2 documents)

    Export disorders for MAP2K7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP2K7 gene, integrated from 10 sources (see all 199):
    (articles sorted by number of sources associating them with MAP2K7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38. (PubMed id 9312068)1, 2, 3, 9 Lu X.... Lin A. (J. Biol. Chem. 1997)
    2. Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli. (PubMed id 9535930)1, 2, 9 Foltz I.N....Schrader J.W. (J. Biol. Chem. 1998)
    3. Cloning and expression of human mitogen-activated protein kinase kinase 7gamma1. (PubMed id 16442502)1, 2, 9 Michael L.... Robinson M.J. (Biochem. Biophys. Res. Commun. 2006)
    4. Mitogen-activated protein kinase kinase 7 is an activator of the c- Jun NH2-terminal kinase. (PubMed id 9207092)1, 2, 9 Tournier C.... Davis R.J. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    5. The JIP group of mitogen-activated protein kinase scaffold proteins. (PubMed id 10490659)1, 2, 9 Yasuda J.... Davis R.J. (Mol. Cell. Biol. 1999)
    6. Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein. (PubMed id 18286207)1, 2, 9 Blanco S.... Lazo P.A. (PLoS ONE 2008)
    7. Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases. (PubMed id 15866172)1, 2 Takekawa M.... Saito H. (Mol. Cell 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1- JNK signaling pathway. A new mode of regulation of the MAP kinase cascade. (PubMed id 12189133)1, 2 Matsuura H.... Ichijo H. (J. Biol. Chem. 2002)
    10. Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor. (PubMed id 11104681)1, 2 Vitale G.... Montecucco C. (Biochem. J. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5609 HGNC: 6847 AceView: MAP2K7 Ensembl:ENSG00000076984 euGenes: HUgn5609
    ECgene: MAP2K7 Kegg: 5609 H-InvDB: MAP2K7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for MAP2K7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP2K7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MAP2K7 gene:
    Search GeneIP for patents involving MAP2K7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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