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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP2K5 Gene

protein-coding   GIFtS: 69
GCID: GC15P067835

Mitogen-Activated Protein Kinase Kinase 5


(Previous symbol: PRKMK5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase Kinase 51 2     EC 2.7.12.23 8
PRKMK51 2 3 5     MAPKK52 5
MEK52 3 5     HsT174542
MAP Kinase Kinase 52 3     Dual Specificity Mitogen-Activated Protein Kinase Kinase 52
MAPK/ERK Kinase 52 3     MAP Kinase Kinase MEK5b2
MAPKK 52 3     MKK53
MEK 52 3     

External Ids:    HGNC: 68451   Entrez Gene: 56072   Ensembl: ENSG000001377647   OMIM: 6025205   UniProtKB: Q131633   

Export aliases for MAP2K5 gene to outside databases

Previous GC identifers: GC15P063628 GC15P060933 GC15P065413 GC15P065550 GC15P065622 GC15P044669


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAP2K5 Gene:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase
family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be
phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The
signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell
differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have
been described. (provided by RefSeq, May 2011)

GeneCards Summary for MAP2K5 Gene: 
MAP2K5 (mitogen-activated protein kinase kinase 5) is a protein-coding gene. Diseases associated with MAP2K5 include developmental coordination disorder, and restless legs syndrome, and among its related super-pathways are MAPK signaling pathway and Gap junction. GO annotations related to this gene include protein serine/threonine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is MAP2K3.

UniProtKB/Swiss-Prot: MP2K5_HUMAN, Q13163
Function: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex.
Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis,
neuronal survival and cardiac development and angiogenesis

Gene Wiki entry for MAP2K5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP2K5 gene promoter:
         AP-1   ATF-2   c-Jun   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP2K5 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP2K5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP2K5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q22.31

MAP2K5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP2K5 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P067835:  view genomic region     (about GC identifiers)

Start:
67,835,021 bp from pter      End:
68,099,461 bp from pter
Size:
264,441 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MP2K5_HUMAN, Q13163 (See protein sequence)
Recommended Name: Dual specificity mitogen-activated protein kinase kinase 5  
Size: 448 amino acids; 50112 Da
Cofactor: Magnesium
Subunit: Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI (By similarity).
Interacts with Yersinia yopJ
3 PDB 3D structures from and Proteopedia for MAP2K5:
2NPT (3D)        2O2V (3D)        4IC7 (3D)    
Secondary accessions: B4DE43 Q92961 Q92962
Alternative splicing: 4 isoforms:  Q13163-1   Q13163-2   Q13163-3   Q13163-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP2K5: NX_Q13163

Explore proteomics data for MAP2K5 at MOPED 

Post-translational modifications:

  • UniProtKB: Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases (By similarity)
  • UniProtKB: Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK
    signaling pathway
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13163

  • 2 DME Specific Peptides for MAP2K5 (Q13163)
     ELALGRFP  KILHRDVKPSNMLVN 

    MAP2K5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAP2K5 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001193733.1  NP_002748.1  NP_660143.1  

    ENSEMBL proteins: 
     ENSP00000178640   ENSP00000378859   ENSP00000346493   ENSP00000390196   ENSP00000342101  
    Reactome Protein details: Q13163
    Human Recombinant Protein Products for MAP2K5: 
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    Novus Biologicals MAP2K5 Proteins
    Novus Biologicals MAP2K5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAP2K5 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005819spindle IEA--
    GO:0005829cytosol IEA--

    MAP2K5 for ontologies           About GeneDecksing



    MAP2K5 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for MAP2K5 
    Cloud-Clone Corp. CLIAs for MAP2K5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MAP2K: Mitogen-activated protein kinase cascade / Kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase 5 
    STE7 family

    5/6 InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q13163

    ProtoNet protein and cluster: Q13163

    1 Blocks protein domain: IPB000270 Octicosapeptide/Phox/Bem1p

    UniProtKB/Swiss-Prot: MP2K5_HUMAN, Q13163
    Domain: Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the OPR domain. This domain also mediates
    interactions with SQSTM1 and PARD6A (By similarity)
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase
    subfamily
    Similarity: Contains 1 OPR domain
    Similarity: Contains 1 protein kinase domain


    MAP2K5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MP2K5_HUMAN, Q13163
    Function: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex.
    Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis,
    neuronal survival and cardiac development and angiogenesis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.12.21 2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS7759517
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI17474147
    GO:0005524ATP binding IEA--
         
    MAP2K5 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MAP2K5:
     Decreased substrate adherent c  Decreased viability with TRAIL  Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Map2k5):
     cardiovascular system  cellular  embryogenesis  growth/size  mortality/aging 
     muscle  normal 

    MAP2K5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAP2K5 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP2K5 
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    hsa-miR-3938 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidMAP2K5 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2K5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAP2K5 About   (see all 45)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Signaling in Gap Junctions
    Signaling in Gap Junctions0.31
    Gap junction0.31
    3ErbB4 Pathway
    ErbB4 Pathway0.59
    TREM1 Pathway0.43
    Prolactin Signaling0.54
    PACAP Signaling0.37
    Thrombopoietin Pathway0.51
    HMGB1 Pathway0.36
    ErbB2-ErbB3 Heterodimers0.49
    IL-4 Pathway0.34
    44-1BB Pathway
    4-1BB Pathway0.54
    PKR Pathway0.36
    CD40 Signaling0.54
    SUMO Pathway0.30
    CD27 Pathway0.48
    5CNTF Signaling
    CNTF Signaling0.50
    OSM Pathway0.46
    FLT3 Signaling0.50
    Nur77-Induced AICD in Macrophage0.45
    IL-3 Pathway0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for MAP2K5
        Immune response Function of MEF2 in T lymphocytes
    Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

    5/61 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP2K5 (see all 61)
        FLT3 Signaling
    IL-4 Pathway
    eIF2 Pathway
    G12-G13 in Cellular Signaling
    Aldosterone Signaling in Epithelial Cells

    2 GeneGo (Thomson Reuters) Pathways for MAP2K5
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes

    5/11 BioSystems Pathways for MAP2K5 (see all 11)
        MAPK signaling pathway
    Focal Adhesion
    MicroRNAs in cardiomyocyte hypertrophy
    EGFR1 Signaling Pathway
    Insulin Signaling

    4        Reactome Pathways for MAP2K5
        Signal Transduction
    Signalling to ERK5
    Signalling by NGF
    NGF signalling via TRKA from the plasma membrane

    1 PharmGKB Pathway for MAP2K5
        VEGF Signaling Pathway

    3         Kegg Pathways  (Kegg details for MAP2K5):
        MAPK signaling pathway
    Gap junction
    Neurotrophin signaling pathway


    MAP2K5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP2K5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/37 Interacting proteins for MAP2K5 (Q131631, 2, 3 ENSP000001786404) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3, ENSP000003549274MINT-47996 MINT-48511 I2D: score=7 STRING: ENSP00000354927
    MAPK7Q131641, 3, ENSP000003110054EBI-307294,EBI-1213983 I2D: score=4 STRING: ENSP00000311005
    ASRGL1Q7L2662, 3, ENSP000003017764MINT-8259855 I2D: score=2 STRING: ENSP00000301776
    GRB2P629931, 3, ENSP000003390074EBI-307294,EBI-401755 I2D: score=1 STRING: ENSP00000339007
    SQSTM1Q135013, ENSP000003744554I2D: score=5 STRING: ENSP00000374455
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0000165MAPK cascade ----
    GO:0000187activation of MAPK activity ISS--
    GO:0006468protein phosphorylation ----
    GO:0007165signal transduction TAS7759517

    MAP2K5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP2K5 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAP2K5:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP2K5 (MP2K5)

    3 HMDB Compounds for MAP2K5    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 Novoseek inferred chemical compound relationships for MAP2K5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pd-184352 88.1 2 11478941 (2)
    pd 98,059 49.7 1 15381709 (1)

    Search CenterWatch for drugs/clinical trials and news about MAP2K5 / MP2K5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAP2K5 gene (5 alternative transcripts): 
    NM_001206804.1  NM_002757.3  NM_145160.2  NM_145161.1  NM_145162.1  

    Unigene Cluster for MAP2K5:

    Mitogen-activated protein kinase kinase 5
    Hs.114198  [show with all ESTs]
    Unigene Representative Sequence: AK025177
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000178640(uc002aqu.3 uc002aqv.3) ENST00000560591 ENST00000395476
    ENST00000560086 ENST00000354498(uc010ujw.2) ENST00000439036 ENST00000558392
    ENST00000559262 ENST00000340972(uc002aqx.3) ENST00000557869 ENST00000558274
    ENST00000558021
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    Additional mRNA sequence: 

    AK024766.1 AK025177.1 AK057521.1 AK092615.1 AK293459.1 AK315435.1 BC008838.2 BT006780.1 
    CR542229.1 U71087.1 U71088.2 

    15 DOTS entries:

    DT.412649  DT.100788475  DT.95184802  DT.100721281  DT.100788479  DT.121023064  DT.95184795  DT.99933541 
    DT.100698791  DT.95184811  DT.97843972  DT.99977252  DT.100788478  DT.101980897  DT.91967795 

    24/75 AceView cDNA sequences (see all 75):

    CR620602 BX349080 BU543744 BX336642 CF272258 BQ938606 BG742777 BI523894 
    BQ957525 BX489865 BF727356 CK430566 AK092615 BG031238 BE622246 AI752491 
    BM047870 BM923045 CD242326 BI915236 AL573417 BX382864 BM925950 AK025177 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP2K5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGGCCCAC
    MAP2K5 Expression
    About this image


    See MAP2K5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP2K5

    SOURCE GeneReport for Unigene cluster: Hs.114198

    UniProtKB/Swiss-Prot: MP2K5_HUMAN, Q13163
    Tissue specificity: Expressed in many adult tissues. Abundant in heart and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAP2K5: 
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Gap Junctions in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP2K5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2K5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAP2K5 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map2k51 , 5 mitogen-activated protein kinase kinase 51, 5 91.07(n)1
    97.77(a)1
      9 (33.96 cM)5
    239381  NM_011840.21  NP_035970.11 
     631637705 
    chicken
    (Gallus gallus)
    Aves MAP2K51 mitogen-activated protein kinase kinase 5 85(n)
    94.3(a)
      415557  NM_001079716.1  NP_001073184.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAP2K56
    mitogen-activated protein kinase kinase 5
    90(a)
    1 ↔ 1
    GL343467.1(482111-622276)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.133162 Xenopus laevis transcribed sequence with moderate similarity more 76.49(n)    BU906182.1 
    zebrafish
    (Danio rerio)
    Actinopterygii map2k51 mitogen-activated protein kinase kinase 5 72(n)
    78.83(a)
      100007679  NM_001114317.1  NP_001107789.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MKK1(YOR231W)4 Mitogen-activated kinase kinase involved in protein more   --   15(772601-774127) 854406  NP_014874.1 


    ENSEMBL Gene Tree for MAP2K5 (if available)
    TreeFam Gene Tree for MAP2K5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP2K5 gene
    MAP2K32  MAP2K22  MAP2K62  MAP2K42  MAP2K72  MAP2K12  
    18/36 SIMAP similar genes for MAP2K5 using alignment to 3 protein entries:     MP2K5_HUMAN (see all proteins) (see all similar genes):
    MAP2K4    MAP2K6    MAP2K3    MAP2K1    DKFZp686L02273    STK25
    MAP2K2    MAP2K7    STK24    MST4    STK3    STK4
    MAP4K2    MAP4K5    TAOK3    MAP4K3    TAOK2    PAK2

    MAP2K5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4938 SNPs in MAP2K5 are shown (see all 4938)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0408244
    ----see VAR_0408242 A V mis40--------
    rs724175401,2
    C--44669452(+) CGCCA-/CG    
       CGCCG
    CGCGC
    2 -- us2k10--------
    rs758795501,2
    C--44669457(+) GCGCCA/GCGCGC 2 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs71810771,2
    C,H--44703711(+) TATATA/TTTTTT 3 -- int1 trp33Minor allele frequency- T:0.00NA 6
    rs283869281,2
    C--44736129(+) ATAGAT/ATCTGT 3 -- int12Minor allele frequency- A:0.00NA 4
    rs287121771,2
    C--44736154(+) GGTCTA/GTAGAT 3 -- int11Minor allele frequency- G:0.00NA 2
    rs286635301,2
    --44736159(+) GTAGAA/TTCTGT 3 -- int10--------
    rs2001602361,2
    C--44747534(+) AGCTA-/TAGGT 
            
    AGGTT
    3 -- int10--------
    rs2002293041,2
    C--44749998(+) TTCTT-/GTTGTT 3 -- int10--------
    rs1494650221,2
    C--44764406(+) GTGTG-/TG/TGT
    G
    /TGTGTG
    AGTGT
    6 -- int1 cds10--------

    HapMap Linkage Disequilibrium report for MAP2K5 (67835021 - 68085021 bp, first 250kb of MAP2K5)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for MAP2K5 (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv991898CNV Deletion20482838
    esv2749809CNV Deletion23290073
    esv2749803CNV Deletion23290073
    esv2749801CNV Deletion23290073
    esv2749804CNV Deletion23290073
    esv2749806CNV Deletion23290073
    esv1065122CNV Deletion17803354
    esv2749805CNV Deletion23290073
    esv1001492CNV Deletion20482838
    esv2749802CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602520    OMIM disorders: --

    15 diseases for MAP2K5:    About MalaCards
    developmental coordination disorder    restless legs syndrome    sleep disorder    medulloblastoma
    prostate cancer    glioblastoma    hepatitis c    prostatitis
    obesity    breast cancer    colorectal cancer    hepatitis
    endotheliitis    leukemia    neuronitis

    1 disease from the University of Copenhagen DISEASES database for MAP2K5:
    Developmental coordination disorder

    MAP2K5 for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for MAP2K5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 24 12 12618764 (5), 15805119 (4), 18071319 (2)
    breast cancer 17.5 3 15378007 (2), 16081048 (1)
    metastasis 13.3 1 12618764 (1)
    breast carcinoma 13.3 6 15378007 (4), 12219026 (1)
    tumors 11.8 2 16081048 (1), 20382528 (1)
    cancer 0 2 12219026 (1), 15378007 (1)

    Genetic Association Database (GAD): MAP2K5
    Human Genome Epidemiology (HuGE) Navigator: MAP2K5 (8 documents)

    Export disorders for MAP2K5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP2K5 gene, integrated from 9 sources (see all 92):
    (articles sorted by number of sources associating them with MAP2K5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Components of a new human protein kinase signal transduction pathway. (PubMed id 7759517)1, 2, 3, 9 Zhou G.... Dixon J.E. (1995)
    2. Meta-analysis identifies common variants associated wi th body mass index in east Asians. (PubMed id 22344219)1, 4 Wen W....Shu X.O. (2012)
    3. Genome-wide association study identifies novel restles s legs syndrome susceptibility loci on 2p14 and 16q12.1. (PubMed id 21779176)1, 4 Winkelmann J....Meitinger T. (2011)
    4. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1, 4 Speliotes E.K....Loos R.J. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Exploring the genetic link between RLS and ADHD. (PubMed id 19223043)1, 4 Schimmelmann B.G....Hebebrand J. (2009)
    7. Association of intronic variants of the BTBD9 gene wi th Tourette syndrome. (PubMed id 19822783)1, 4 RiviA"re J.B....Rouleau G.A. (2009)
    8. Replication of restless legs syndrome loci in three European populations. (PubMed id 19279021)1, 4 Kemlink D....Winkelmann J. (2009)
    9. Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. (PubMed id 17637780)1, 4 Winkelmann J....Meitinger T. (2007)
    10. Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. (PubMed id 16728640)1, 2 Mukherjee S....Orth K. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5607 HGNC: 6845 AceView: MAP2K5 Ensembl:ENSG00000137764 euGenes: HUgn5607
    ECgene: MAP2K5 Kegg: 5607 H-InvDB: MAP2K5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP2K5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP2K5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAP2K5 gene:
    Search GeneIP for patents involving MAP2K5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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