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MAP2K5 Gene

protein-coding   GIFtS: 69
GCID: GC15P067835

Mitogen-Activated Protein Kinase Kinase 5


(Previous symbol: PRKMK5)
  See MAP2K5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase Kinase 51 2     EC 2.7.12.23 8
PRKMK51 2 3 5     MAPKK52 5
MEK52 3 5     HsT174542
MAP Kinase Kinase 52 3     Dual Specificity Mitogen-Activated Protein Kinase Kinase 52
MAPK/ERK Kinase 52 3     MAP Kinase Kinase MEK5b2
MAPKK 52 3     MKK53
MEK 52 3     

External Ids:    HGNC: 68451   Entrez Gene: 56072   Ensembl: ENSG000001377647   OMIM: 6025205   UniProtKB: Q131633   

Export aliases for MAP2K5 gene to outside databases

Previous GC identifers: GC15P063628 GC15P060933 GC15P065413 GC15P065550 GC15P065622 GC15P044669


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP2K5 Gene:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase
family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be
phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The
signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell
differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have
been described. (provided by RefSeq, May 2011)

GeneCards Summary for MAP2K5 Gene:
MAP2K5 (mitogen-activated protein kinase kinase 5) is a protein-coding gene. Diseases associated with MAP2K5 include developmental coordination disorder. GO annotations related to this gene include protein serine/threonine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is MAP2K3.

UniProtKB/Swiss-Prot: MP2K5_HUMAN, Q13163
Function: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex.
Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis,
neuronal survival and cardiac development and angiogenesis

Gene Wiki entry for MAP2K5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP2K5 gene promoter:
         AP-1   ATF-2   c-Jun   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP2K5 promoter sequence
   Search Chromatin IP Primers for MAP2K5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP2K5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q22.31

MAP2K5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP2K5 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P067835:  view genomic region     (about GC identifiers)

Start:
67,835,021 bp from pter      End:
68,099,461 bp from pter
Size:
264,441 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MP2K5_HUMAN, Q13163 (See protein sequence)
Recommended Name: Dual specificity mitogen-activated protein kinase kinase 5  
Size: 448 amino acids; 50112 Da
Cofactor: Magnesium
Subunit: Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI (By similarity).
Interacts with Yersinia yopJ
3 PDB 3D structures from and Proteopedia for MAP2K5:
2NPT (3D)        2O2V (3D)        4IC7 (3D)    
Secondary accessions: B4DE43 Q92961 Q92962
Alternative splicing: 4 isoforms:  Q13163-1   Q13163-2   Q13163-3   Q13163-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP2K5: NX_Q13163

Explore proteomics data for MAP2K5 at MOPED

Post-translational modifications: 

  • Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases (By similarity)1
  • Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK
    signaling pathway1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for MAP2K5 (Q13163)
     ELALGRFP  KILHRDVKPSNMLVN 


    See MAP2K5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001193733.1  NP_002748.1  NP_660143.1  

    ENSEMBL proteins: 
     ENSP00000178640   ENSP00000378859   ENSP00000346493   ENSP00000390196   ENSP00000342101  
    Reactome Protein details: Q13163

    MAP2K5 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for MAP2K5

     
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    antibodies-online proteins for MAP2K5 (5 products) 

     
    antibodies-online peptides for MAP2K5

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    antibodies-online antibodies for MAP2K5 (133 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAP2K: Mitogen-activated protein kinase cascade / Kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase 5
    STE7 family

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q13163

    ProtoNet protein and cluster: Q13163

    1 Blocks protein domain: IPB000270 Octicosapeptide/Phox/Bem1p

    UniProtKB/Swiss-Prot: MP2K5_HUMAN, Q13163
    Domain: Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the OPR domain. This domain also mediates
    interactions with SQSTM1 and PARD6A (By similarity)
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase
    subfamily
    Similarity: Contains 1 OPR domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with MAP2K5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MP2K5_HUMAN, Q13163
    Function: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex.
    Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis,
    neuronal survival and cardiac development and angiogenesis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.12.21 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS7759517
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI17474147
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with MAP2K5           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for MAP2K5:
     Decreased substrate adherent c  Decreased viability with TRAIL  Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Map2k5):
     cardiovascular system  cellular  embryogenesis  growth/size/body  mortality/aging 
     muscle  normal 

    Find genes that share phenotypes with MAP2K5           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MAP2K5

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAP2K5:
    hsa-mir-335-5p (MIRT018716), hsa-mir-214-3p (MIRT024959)

    Block miRNA regulation of human, mouse, rat MAP2K5 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MAP2K5:
    hsa-miR-3938 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidMAP2K5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAP2K5
    Predesigned siRNA for gene silencing in human, mouse, rat MAP2K5

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): MAP2K5 (NM_002757)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP2K5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP2K5
    Addgene plasmids for MAP2K5 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2K5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    cytosol2
    extracellular2
    nucleus2
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005819spindle IEA--
    GO:0005829cytosol IEA--

    Find genes that share ontologies with MAP2K5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP2K5 About   (see all 44)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Signaling in Gap Junctions
    Gap junction0.31
    Signaling in Gap Junctions0.31
    3Trk receptor signaling mediated by the MAPK pathway
    Trk receptor signaling mediated by the MAPK pathway
    Signalling to ERK50.00
    4ErbB4 Pathway
    ErbB4 Pathway0.59
    TREM1 Pathway0.43
    Prolactin Signaling0.54
    FGF Pathway0.37
    Thrombopoietin Pathway0.51
    PACAP Signaling0.37
    ErbB2-ErbB3 Heterodimers0.49
    HMGB1 Pathway0.36
    54-1BB Pathway
    4-1BB Pathway0.54
    PKR Pathway0.36
    CD40 Signaling0.54
    SUMO Pathway0.30
    CD27 Pathway0.48


    Find genes that share SuperPaths with MAP2K5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAP2K5 (see all 61)
        FLT3 Signaling
    IL-4 Pathway
    eIF2 Pathway
    G12-G13 in Cellular Signaling
    Aldosterone Signaling in Epithelial Cells

    2 GeneGo (Thomson Reuters) Pathways for MAP2K5
        Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
    Immune response Function of MEF2 in T lymphocytes

    Selected BioSystems Pathways for MAP2K5 (see all 11)
        MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    Integrin-mediated cell adhesion
    EGFR1 Signaling Pathway

    1 Reactome Pathway for MAP2K5
        Signalling to ERK5

    1 PharmGKB Pathway for MAP2K5
        VEGF Signaling Pathway

    4 Kegg Pathways  (Kegg details for MAP2K5):
        MAPK signaling pathway
    Gap junction
    Neurotrophin signaling pathway
    Oxytocin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP2K5: 
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Gap Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAP2K5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAP2K5 (Q131631, 2, 3 ENSP000001786404) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3, ENSP000003549274MINT-47996 MINT-48511 I2D: score=7 STRING: ENSP00000354927
    MAPK7Q131641, 3, ENSP000003110054EBI-307294,EBI-1213983 I2D: score=4 STRING: ENSP00000311005
    ASRGL1Q7L2662, 3, ENSP000003017764MINT-8259855 I2D: score=2 STRING: ENSP00000301776
    GRB2P629931, 3, ENSP000003390074EBI-307294,EBI-401755 I2D: score=1 STRING: ENSP00000339007
    SQSTM1Q135013, ENSP000003744554I2D: score=5 STRING: ENSP00000374455
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0000165MAPK cascade ----
    GO:0000187activation of MAPK activity ISS--
    GO:0006468protein phosphorylation ----
    GO:0007165signal transduction TAS7759517

    Find genes that share ontologies with MAP2K5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAP2K5 (MP2K5)

    3 HMDB Compounds for MAP2K5    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 Novoseek inferred chemical compound relationships for MAP2K5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pd-184352 88.1 2 11478941 (2)
    pd 98,059 49.7 1 15381709 (1)



    Find genes that share compounds with MAP2K5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAP2K5 gene (5 alternative transcripts): 
    NM_001206804.1  NM_002757.3  NM_145160.2  NM_145161.1  NM_145162.1  

    Unigene Cluster for MAP2K5:

    Mitogen-activated protein kinase kinase 5
    Hs.114198  [show with all ESTs]
    Unigene Representative Sequence: AK025177
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000178640(uc002aqu.3 uc002aqv.3) ENST00000560591 ENST00000395476
    ENST00000560086 ENST00000354498(uc010ujw.2) ENST00000439036 ENST00000558392
    ENST00000559262 ENST00000340972(uc002aqx.3) ENST00000557869 ENST00000558274
    ENST00000558021
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    hsa-miR-3938 hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidMAP2K5 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MAP2K5
      QuantiFast Probe-based Assays in human, mouse, rat MAP2K5

    Additional mRNA sequence: 

    AK024766.1 AK025177.1 AK057521.1 AK092615.1 AK293459.1 AK315435.1 BC008838.2 BT006780.1 
    CR542229.1 U71087.1 U71088.2 

    15 DOTS entries:

    DT.412649  DT.100788475  DT.95184802  DT.100721281  DT.100788479  DT.121023064  DT.95184795  DT.99933541 
    DT.100698791  DT.95184811  DT.97843972  DT.99977252  DT.100788478  DT.101980897  DT.91967795 

    Selected AceView cDNA sequences (see all 75):

    BX489865 CF272258 BX349080 CR620602 BQ957525 BG742777 BU543744 BX336642 
    BI523894 BQ938606 BQ719660 CD675610 BF207340 BF061899 BE622246 BX382864 
    BF727356 BM925950 CK430566 BM048506 BF338538 BQ918987 BX506117 AK092615 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAP2K5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGGCCCAC
    MAP2K5 Expression
    About this image


    MAP2K5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    MAP2K5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP2K5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.114198

    UniProtKB/Swiss-Prot: MP2K5_HUMAN, Q13163
    Tissue specificity: Expressed in many adult tissues. Abundant in heart and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP2K5: 
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Gap Junctions in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for MAP2K5
    OriGene qSTAR qPCR primer pairs in human, mouse for MAP2K5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAP2K5
    QuantiTect SYBR Green Assays in human, mouse, rat MAP2K5
    QuantiFast Probe-based Assays in human, mouse, rat MAP2K5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2K5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAP2K5 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map2k51 , 5 mitogen-activated protein kinase kinase 51, 5 91.07(n)1
    97.77(a)1
      9 (33.96 cM)5
    239381  NM_011840.21  NP_035970.11 
     631637705 
    chicken
    (Gallus gallus)
    Aves MAP2K51 mitogen-activated protein kinase kinase 5 85(n)
    94.3(a)
      415557  NM_001079716.1  NP_001073184.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAP2K56
    mitogen-activated protein kinase kinase 5
    91(a)
    1 ↔ 1
    GL343467.1(482111-622276)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.133162 Xenopus laevis transcribed sequence with moderate similarity more 76.49(n)    BU906182.1 
    zebrafish
    (Danio rerio)
    Actinopterygii map2k51 mitogen-activated protein kinase kinase 5 72(n)
    78.83(a)
      100007679  NM_001114317.1  NP_001107789.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MKK1(YOR231W)4 Mitogen-activated kinase kinase involved in protein more   --   15(772601-774127) 854406  NP_014874.1 


    ENSEMBL Gene Tree for MAP2K5 (if available)
    TreeFam Gene Tree for MAP2K5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP2K5 gene
    MAP2K32  MAP2K22  MAP2K62  MAP2K42  MAP2K72  MAP2K12  
    Selected SIMAP similar genes for MAP2K5 using alignment to 3 protein entries:     MP2K5_HUMAN (see all proteins) (see all similar genes):
    MAP2K6    MAP2K3    MAP2K1    DKFZp686L02273    MAP2K4    STK25
    MAP2K2    MAP2K7    STK24    MST4    STK3    STK4
    MAP4K2    MAP4K5    TAOK3    MAP4K3    TAOK2    PAK2

    Find genes that share paralogs with MAP2K5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP2K5 (see all 4938)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs724175401,2
    C--44669452(+) CGCCA-/CG    
       CGCCG
    CGCGC
    2 -- us2k10--------
    rs758795501,2
    C--44669457(+) GCGCCA/GCGCGC 2 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs71810771,2
    C,H--44703711(+) TATATA/TTTTTT 3 -- int1 trp33Minor allele frequency- T:0.00NA 6
    rs283869281,2
    C--44736129(+) ATAGAT/ATCTGT 3 -- int12Minor allele frequency- A:0.00NA 4
    rs287121771,2
    C--44736154(+) GGTCTA/GTAGAT 3 -- int11Minor allele frequency- G:0.00NA 2
    rs286635301,2
    --44736159(+) GTAGAA/TTCTGT 3 -- int10--------
    rs2001602361,2
    C--44747534(+) AGCTA-/TAGGT 
            
    AGGTT
    3 -- int10--------
    rs2002293041,2
    C--44749998(+) TTCTT-/GTTGTT 3 -- int10--------
    rs1494650221,2
    C--44764406(+) GTGTG-/TG/TGT
    G
    /TGTGTG
    AGTGT
    6 -- int1 cds10--------
    rs58134511,2
    C--44785370(+) TTCTG-/A/AA  
            
    AAAAA
    3 -- int1 trp32NA CSA 4

    HapMap Linkage Disequilibrium report for MAP2K5 (67835021 - 68085021 bp, first 250kb of MAP2K5)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAP2K5 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv991898CNV Deletion20482838
    esv2749809CNV Deletion23290073
    esv2749803CNV Deletion23290073
    esv2749801CNV Deletion23290073
    esv2749804CNV Deletion23290073
    esv2749806CNV Deletion23290073
    esv1065122CNV Deletion17803354
    esv2749805CNV Deletion23290073
    esv1001492CNV Deletion20482838
    esv2749802CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP2K5
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP2K5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602520    OMIM disorders: --

    1 disease for MAP2K5:    
    About MalaCards
    developmental coordination disorder

    1 disease from the University of Copenhagen DISEASES database for MAP2K5:
    Developmental coordination disorder

    Find genes that share disorders with MAP2K5           About GenesLikeMe

    6 Novoseek inferred disease relationships for MAP2K5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 24 12 12618764 (5), 15805119 (4), 18071319 (2)
    breast cancer 17.5 3 15378007 (2), 16081048 (1)
    metastasis 13.3 1 12618764 (1)
    breast carcinoma 13.3 6 15378007 (4), 12219026 (1)
    tumors 11.8 2 16081048 (1), 20382528 (1)
    cancer 0 2 12219026 (1), 15378007 (1)

    Genetic Association Database (GAD): MAP2K5
    Human Genome Epidemiology (HuGE) Navigator: MAP2K5 (8 documents)

    Export disorders for MAP2K5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP2K5 gene, integrated from 10 sources (see all 94):
    (articles sorted by number of sources associating them with MAP2K5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Components of a new human protein kinase signal transduction pathway. (PubMed id 7759517)1, 2, 3, 9 Zhou G.... Dixon J.E. (J. Biol. Chem. 1995)
    2. Meta-analysis identifies common variants associated with body mass index in east Asians. (PubMed id 22344219)1, 4 Wen W....Shu X.O. (Nat. Genet. 2012)
    3. Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. (PubMed id 21779176)1, 4 Winkelmann J....Meitinger T. (PLoS Genet. 2011)
    4. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1, 4 Speliotes E.K....Loos R.J. (Nat. Genet. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Exploring the genetic link between RLS and ADHD. (PubMed id 19223043)1, 4 Schimmelmann B.G....Hebebrand J. (J Psychiatr Res 2009)
    7. Association of intronic variants of the BTBD9 gene with Tourette syndrome. (PubMed id 19822783)1, 4 RiviA"re J.B....Rouleau G.A. (Arch. Neurol. 2009)
    8. Replication of restless legs syndrome loci in three European populations. (PubMed id 19279021)1, 4 Kemlink D....Winkelmann J. (J. Med. Genet. 2009)
    9. Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. (PubMed id 17637780)1, 4 Winkelmann J....Meitinger T. (Nat. Genet. 2007)
    10. Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. (PubMed id 16728640)1, 2 Mukherjee S....Orth K. (Science 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5607 HGNC: 6845 AceView: MAP2K5 Ensembl:ENSG00000137764 euGenes: HUgn5607
    ECgene: MAP2K5 Kegg: 5607 H-InvDB: MAP2K5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAP2K5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP2K5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MAP2K5 gene:
    Search GeneIP for patents involving MAP2K5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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