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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MAP2K5 Gene

protein-coding GIFtS: 67
GCID: GC15P067835

mitogen-activated protein kinase kinase 5

(Previous symbol: PRKMK5)

Explore 14 diseases affiliated with
MAP2K5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase Kinase 5¹ ²		MAPKK 5² ³
MEK5¹ ² ³ ⁵		MEK 5² ³
PRKMK5¹ ² ³ ⁵		EC 2.7.12.2³ ⁸
MAPKK5¹ ² ⁵		Dual Specificity Mitogen-Activated Protein Kinase Kinase 5²
HsT17454¹ ²		MAP Kinase Kinase MEK5b²
MAP Kinase Kinase 5² ³		MKK5³
MAPK/ERK Kinase 5² ³

External Ids:	HGNC: 6845¹	Entrez Gene: 5607²	Ensembl: ENSG00000137764⁷	OMIM: 602520⁵	UniProtKB: Q13163³

Export aliases for MAP2K5 gene to outside databases

Previous GC identifers: GC15P063628 GC15P060933 GC15P065413 GC15P065550 GC15P065622 GC15P044669

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAP2K5:

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family.

This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and

activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by

this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three

alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. (provided by

RefSeq, May 2011)

UniProtKB/Swiss-Prot: MP2K5_HUMAN, Q13163

Function: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of

this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and

cardiac development and angiogenesis

Gene Wiki entry for MAP2K5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MAP2K5 gene promoter:
AP-1 ATF-2 c-Jun NF-kappaB NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAP2K5 promoter sequence

Search SABiosciences Chromatin IP Primers for MAP2K5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP2K5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23 Ensembl cytogenetic band: 15q23 HGNC cytogenetic band: 15q22.31

MAP2K5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP2K5 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P067835: view genomic region (about GC identifiers)

Start:	67,835,021 bp from pter	End:	68,099,461 bp from pter
Size:	264,441 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MP2K5_HUMAN, Q13163 (See protein sequence)

Recommended Name: Dual specificity mitogen-activated protein kinase kinase 5

Size: 448 amino acids; 50112 Da

Cofactor: Magnesium

Subunit: Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI (By similarity).

Interacts with Yersinia yopJ

3 PDB 3D structures from and Proteopedia for MAP2K5:

2NPT (3D)

2O2V (3D)

4IC7 (3D)

Secondary accessions: B4DE43 Q92961 Q92962

Alternative splicing: 4 isoforms: Q13163-1 Q13163-2 Q13163-3 Q13163-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP2K5: NX_Q13163

Post-translational modifications:

Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases (By similarity)¹

Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK

signaling pathway¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13163

2 DME Specific Peptides for MAP2K5 (Q13163)

ELALGRFP

KILHRDVKPSNMLVN

MAP2K5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001193733.1 NP_002748.1 NP_660143.1

ENSEMBL proteins:

ENSP00000178640 ENSP00000378859 ENSP00000346493 ENSP00000390196 ENSP00000342101

Reactome Protein details: Q13163
Human Recombinant Protein Products for MAP2K5:

	EMD Millipore Purified and/or Recombinant MAP2K5 Protein
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	Novus Biologicals MAP2K5 Proteins Novus Biologicals MAP2K5 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MAP2K5

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005819	spindle	IEA	--
GO:0005829	cytosol	IEA	--

MAP2K5 for ontologies About GeneDecksing

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MAP2K5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MAP2K5 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR017441 Protein_kinase_ATP_BS

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry Q13163

ProtoNet protein and cluster: Q13163

1 Blocks protein family: IPB000270 Octicosapeptide/Phox/Bem1p

UniProtKB/Swiss-Prot: MP2K5_HUMAN, Q13163

Domain: Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the OPR domain. This domain also mediates

interactions with SQSTM1 and PARD6A (By similarity)

Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily

Similarity: Contains 1 OPR domain

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MP2K5_HUMAN, Q13163

Function: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of

this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and

cardiac development and angiogenesis

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.12.2¹ ²

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	TAS	7759517
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0004707	MAP kinase activity	--	--
GO:0004713	protein tyrosine kinase activity	IEA	--
GO:0005515	protein binding	IPI	17474147

MAP2K5 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for MAP2K5:

Decreased substrate adherent c

Decreased viability with TRAIL

Synthetic lethal with Ras

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Map2k5):

cardiovascular system	cellular	embryogenesis	growth/size	mortality/aging
muscle	normal

MAP2K5 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MAP2K5

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		hsa-miR-3938 hsa-miR-330-3p
		SwitchGear 3'UTR luciferase reporter plasmid: MAP2K5 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2K5

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/44 super-pathways (see all 44) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

ErbB4 Pathway

8/10 pathways (see all 10)
ErbB4 Pathway	1.00	VEGF Signaling Pathway	0.35
Prolactin Signaling	0.54	TREM1 Pathway	0.32
ErbB2-ErbB3 Heterodimers	0.47	HMGB1 Pathway	0.32
IL-2 Pathway	0.46	IL-4 Pathway	0.28

4-1BB Pathway

4-1BB Pathway	1.00	PKR Pathway	0.36
CD40 Signaling	0.54	SUMO Pathway	0.30
CD27 Pathway	0.48

CNTF Signaling

CNTF Signaling	1.00	OSM Pathway	0.46
FLT3 Signaling	0.50	Nur77-Induced AICD in Macrophage	0.27
IL-3 Pathway	0.46

TGF-Beta Pathway

	TGF-Beta Pathway	1.00			JAK-STAT Pathway	0.57
	MAPK Family Pathway	0.60			Regulation of eIF4 and p70S6K	0.43

GPCR Pathway

	GPCR Pathway	1.00			Breast Cancer Regulation by Stathmin1	0.58
	Ras Pathway	0.62			P2Y Receptor Signaling	0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for MAP2K5

	Immune response Function of MEF2 in T lymphocytes
	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis

5/61 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP2K5 (see all 61)

	FLT3 Signaling
	IL-4 Pathway
	eIF2 Pathway
	G12-G13 in Cellular Signaling
	Aldosterone Signaling in Epithelial Cells

2 GeneGo (Thomson Reuters) Pathways for MAP2K5

	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
	Immune response Function of MEF2 in T lymphocytes

5/10 BioSystems Pathways for MAP2K5 (see all 10)

	MicroRNAs in cardiomyocyte hypertrophy
	MAPK signaling pathway
	Signaling Pathways in Glioblastoma
	Integrin-mediated cell adhesion
	Focal Adhesion

4 Reactome Pathways for MAP2K5

	Signal Transduction
	Signalling to ERK5
	Signalling by NGF
	NGF signalling via TRKA from the plasma membrane

1 PharmGKB Pathway for MAP2K5

VEGF Signaling Pathway

3 Kegg Pathways (Kegg details for MAP2K5):

	MAPK signaling pathway
	Gap junction
	Neurotrophin signaling pathway

MAP2K5 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MAP2K5

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

5/37 Interacting proteins for MAP2K5 (Q13163^{1, 2, 3} ENSP00000178640⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 37)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAP3K3	Q99759²^,³, ENSP00000354927⁴	MINT-47996 MINT-48511 I2D: score=7 STRING: ENSP00000354927
MAPK7	Q13164¹^,³, ENSP00000311005⁴	EBI-1965637,EBI-1213983 I2D: score=4 STRING: ENSP00000311005
ASRGL1	Q7L266²^,³, ENSP00000301776⁴	MINT-8259855 I2D: score=2 STRING: ENSP00000301776
GRB2	P62993¹^,³, ENSP00000339007⁴	EBI-1965637,EBI-401755 I2D: score=1 STRING: ENSP00000339007
SQSTM1	Q13501³, ENSP00000374455⁴	I2D: score=5 STRING: ENSP00000374455

About this table

Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	ISS	--
GO:0000165	MAPK cascade	--	--
GO:0000187	activation of MAPK activity	ISS	--
GO:0006468	protein phosphorylation	--	--
GO:0007165	signal transduction	TAS	7759517

MAP2K5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MAP2K5 for compounds About GeneDecksing

EMD Millipore small molecules for MAP2K5:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MAP2K5

3 HMDB Compounds for MAP2K5 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

2 Novoseek chemical compound relationships for MAP2K5 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pd-184352	88.1	2	11478941 (2)
pd 98,059	49.7	1	15381709 (1)

Search CenterWatch for drugs/clinical trials and news about MAP2K5 / MP2K5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MAP2K5 gene (5 alternative transcripts):

NM_001206804.1 NM_002757.3 NM_145160.2 NM_145161.1 NM_145162.1

Unigene Cluster for MAP2K5:

Mitogen-activated protein kinase kinase 5

Hs.114198 [show with all ESTs]

Unigene Representative Sequence: AK025177

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000178640(uc002aqu.3 uc002aqv.3) ENST00000560591 ENST00000395476

ENST00000560086 ENST00000354498(uc010ujw.2) ENST00000439036 ENST00000558392

ENST00000559262 ENST00000340972(uc002aqx.3) ENST00000557869 ENST00000558274

ENST00000558021

miRNA Products:		OriGene 3'-UTR Clone (see all 2): MAP2K5 Browse OriGene MicroRNA Expression Plasmids
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		Sirion Biotech Custom design and validation of potent shRNA sequences against MAP2K5

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Additional cDNA sequence:

AK024766.1 AK025177.1 AK057521.1 AK092615.1 AK293459.1 AK315435.1 BC008838.2 BT006780.1

CR542229.1 U71087.1 U71088.2

15 DOTS entries:

DT.412649 DT.100788475 DT.95184802 DT.100721281 DT.100788479 DT.121023064 DT.95184795 DT.99933541

DT.100698791 DT.95184811 DT.97843972 DT.99977252 DT.100788478 DT.101980897 DT.91967795

24/75 AceView cDNA sequences (see all 75):

BX336642 BU543744 BX349080 CF272258 CR620602 BI523894 BX489865 BG742777

BQ957525 BQ938606 BM472505 BX367355 BG677177 BQ719660 BF207340 AK025177

BF338538 BG912056 BE622246 BM925950 BM705503 BM047870 AL573417 BF061899

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MAP2K5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGGCCCAC

About this image

MAP2K5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Left Ventricle

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MAP2K5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAP2K5

SOURCE GeneReport for Unigene cluster: Hs.114198

UniProtKB/Swiss-Prot: MP2K5_HUMAN, Q13163

Tissue specificity: Expressed in many adult tissues. Abundant in heart and skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Arrays including MAP2K5:

MAP Kinase (MAPK) Signaling Pathway in human mouse rat

Gap Junctions in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP2K5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2K5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAP2K5 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MAP2K5¹	mitogen-activated protein kinase kinase 5	85(n) 94.3(a)		415557 NM_001079716.1 NP_001073184.1
lizard (Anolis carolinensis)	Reptilia	MAP2K5⁶	--	86(a)	1 ↔ 1	GL343467.1(480921-621036)
African clawed frog (Xenopus laevis)	Amphibia	Xl.13316²	Xenopus laevis transcribed sequence with moderate similarity more	76.49(n)		BU906182.1
zebrafish (Danio rerio)	Actinopterygii	map2k5¹	mitogen-activated protein kinase kinase 5	72(n) 78.83(a)		100007679 NM_001114317.1 NP_001107789.1
thale cress (Arabidopsis thaliana)	eudicotyledons	ATMKK9⁶ ATMKK7⁶ (see all 10)	MAP kinase kinase 7 (see all 10)	33(a) 32(a) (see all 10)	possible ortholog possible ortholog (see all 10)	1(27639091-27640529) 1(6315651-6316738)
rice (Oryza sativa)	Liliopsida	-- -- (see all 11)	STE_MEK_ste7_MAP2K.2 - STE kinases include homolog... OsMKK1 - putative MAPKK based on amino acid sequen... (see all 11)	31(a) 30(a) (see all 11)	possible ortholog possible ortholog (see all 11)	1(17903729-17909128) 6(2497848-2501902)

ENSEMBL Gene Tree for MAP2K5 (if available)
TreeFam Gene Tree for MAP2K5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MAP2K5 gene

MAP2K3² MAP2K2² MAP2K6² MAP2K4² MAP2K7² MAP2K1²

18/36 SIMAP similar genes for MAP2K5 using alignment to 3 protein entries: MP2K5_HUMAN (see all proteins) (see all similar genes):

MAP2K4 MAP2K6 MAP2K3 MAP2K1 DKFZp686L02273 STK25

MAP2K2 MAP2K7 STK24 MST4 STK3 STK4

MAP4K2 MAP4K5 TAOK3 MAP4K3 TAOK2 PAK2

MAP2K5 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs62015102^1,2		--	44668638(+)	`TTACTC/TGGCAG`	2	--	us2k¹		2		NA WA	120
rs113151229^1,2		--	44668645(+)	`GCAGGG/AGTTGG`	2	--	us2k¹		1		CSA	2
rs56332896^1,2	C,F	--	44669381(+)	`CGCCGC/TGGGCG`	2	--	us2k¹		1		NA	120
rs75879550^1,2	C	--	44669458(+)	`GCGCCA/GCNNNN`	2	--	us2k¹		1		CSA	1
rs11550176^1,2	C	--	44669869(+)	`CCCCAA/GACCGA`	2	--	ut5¹ ese³		4		CSA WA NA EA	360
rs8038578^1,2	A	--	44669980(+)	`GGCCTC/TTGCCC`	2	--	ut5¹ ese³		0	--	--	--	--
rs8037896^1,2	A	--	44670134(+)	`tgcccC/Gtcact`	2	--	ut5¹ ese³		0	--	--	--	--
rs2583591^1,2	C	--	44670656(-)	`TCTCTG/TCTAGA`	2	--	int¹ trp³		1		CSA	2
rs16950958^1,2	C,F	--	44671556(+)	`ACAGAA/CGCGGA`	2	--	int¹		5		NA WA	262
rs2583588^1,2	C,F,H	--	44671686(-)	`AGTTAT/CAGAAA`	2	--	int¹		5		NS EA WA	536

HapMap Linkage Disequilibrium report for MAP2K5 (67835021 - 68085021 bp, first 250kb of MAP2K5)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for MAP2K5
1 CNV: 102123
3 Indels: 76990 66826 87724

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MAP2K5 for disorders           About GeneDecksing

OMIM gene information: 602520    OMIM disorders: --

14 diseases for MAP2K5:    About MalaCards

restless legs syndrome tourette syndrome sleep disorder hepatitis c

adhd prostate cancer breast cancer medulloblastoma

prostatitis hepatitis leukemia neuronitis

colorectal cancer glioblastoma

1 disease from the University of Copenhagen DISEASES database for MAP2K5:

Developmental coordination disorder

6 Novoseek disease relationships for MAP2K5 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	24	12	12618764 (5), 15805119 (4), 18071319 (2)
breast cancer	17.5	3	15378007 (2), 16081048 (1)
metastasis	13.3	1	12618764 (1)
breast carcinoma	13.3	6	15378007 (4), 12219026 (1)
tumors	11.8	2	16081048 (1), 20382528 (1)
cancer	0	2	12219026 (1), 15378007 (1)

Human Genome Epidemiology (HuGE) Navigator: MAP2K5 (8 documents)

Export disorders for MAP2K5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MAP2K5 gene, integrated from 9 sources (see all 85):
(articles sorted by number of sources associating them with MAP2K5)

Utopia: connect your pdf to the dynamic
world of online information

Components of a new human protein kinase signal transduction pathway. (PubMed id 7759517)^{1, 2, 3, 9} Zhou G.... Dixon J.E. (1995)
Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. (PubMed id 16728640)^{1, 2} Mukherjee S....Orth K. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C. (PubMed id 9384584)^{1, 2} Kato Y....Lee J.-D. (1997)
Stat3 upregulates MEK5 expression in human breast cancer cells. (PubMed id 15378007)^{1, 9} Song H....Lin J. (2004)
MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion. (PubMed id 12618764)^{1, 9} Mehta P.B....Leung H.Y. (2003)
c-myc Promoter-binding protein 1 (MBP-1) regulates prostate cancer cell growth by inhibiting MAPK pathway. (PubMed id 15805119)^{1, 9} Ghosh A.K....Ray R.B. (2005)
MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation. (PubMed id 15075238)^{1, 9} Raviv Z.... Seger R. (2004)
Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarray. (PubMed id 12219026)^{1, 9} Weldon C.B....Burow M.E. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5607	HGNC: 6845	AceView: MAP2K5	Ensembl:ENSG00000137764	euGenes: HUgn5607
ECgene: MAP2K5	Kegg: 5607	H-InvDB: MAP2K5

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MAP2K5	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MAP2K5	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MAP2K5 gene
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Patent Information for MAP2K5 gene:
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GeneCards and IP:
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MAP2K5 Gene

mitogen-activated protein kinase kinase 5

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MAP2K5 Gene

mitogen-activated protein kinase kinase 5

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