MAP2K4 Gene
protein-coding GIFtS : 69 GCID: GC17 P011864
mitogen-activated protein kinase kinase 4 SERK1 )
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Aliasesfor MAP2K4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Mitogen-Activated Protein Kinase Kinase 4 1 2 MAP Kinase Kinase 42 3 JNKK11 2 3 5 MAPK/ERK Kinase 42 3 PRKMK41 2 3 5 MAPKK 42 3 SERK11 2 3 5 MEK 42 3 MEK41 2 3 SAPK Kinase 12 3 MKK41 2 3 SAPK/ERK Kinase 12 3 Stress-Activated Protein Kinase Kinase 12 3 EC 2.7.12.23 8 JNKK2 3 MAPKK42 5 SAPKK-12 3 Dual Specificity Mitogen-Activated Protein Kinase Kinase 42 SAPKK12 3 JNK Activating Kinase 12 SEK12 3 JNK-Activated Kinase 12 C-Jun N-Terminal Kinase Kinase 12 3 SKK13 JNK-Activating Kinase 12 3
Export aliases for MAP2K4 gene to outside databases Previous GC identifers: GC17P012290 GC17P013039 GC17P011868 GC17P012124
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Summariesfor MAP2K4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MAP2K4 : This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: MP2K4_HUMAN, P45985 Function : Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transductionpathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14 Gene Wiki entry for MAP2K4
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Genomic Viewsfor MAP2K4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000017.10 NC_018928.1 NT_010718.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MAP2K4 gene promoter:GR ER-alpha AML1a AP-1 ATF-2 CUTL1 NF-E2 p45 GR-alpha c-Jun NF-E2 Other transcription factors Search SABiosciences Chromatin IP Primers for MAP2K4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP2K4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17p12 Ensembl cytogenetic band: 17p12 HGNC cytogenetic band: 17p12 MAP2K4 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17P011864: view genomic region
(about GC identifiers )
Start: 11,924,135 bp from pter End:
12,047,147 bp from pter
Size: 123,013 bases Orientation:
plus strand
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Proteinsfor MAP2K4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: MP2K4_HUMAN, P45985 See
protein sequence )Recommended Name: Size : 399 amino acids; 44288 DaSubunit : Interacts with SPAG9 (By similarity). Interacts (via its D domain) with its substrates MAPK8/JNK1, MAPK9/JNK2,MAPK10/JNK3, MAPK11 and MAPK14. Interacts (via its DVD domain) with MAP3Ks activators like MAP3K1/MEKK1 and MAP3K11/MLK3. Interacts with ARRB1, ARRB2 and MAPK8IP3/JIP3
Subcellular location : Cytoplasm (By similarity). Nucleus (By similarity)3 PDB 3D structures from :3ALN (3D) 3ALO (3D) 3VUT (3D) Secondary accessions : B2R7N7 B3KYB2 D3DTS5 Q5U0B8 Q6FHX4 Q6P9H2 Q6PIE6Alternative splicing : 2 isoforms : P45985-1 P45985-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MAP2K4: NX_P45985 Post-translational modifications:
Activated by phosphorylation on Ser-257 and Thr-261 by MAP kinase kinase kinases (MAP3Ks)1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P45985 4 DME Specific Peptides for MAP2K4 (P45985 ) MAP2K4 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_003001.1 ENSEMBL proteins: ENSP00000262445 ENSP00000463507 ENSP00000410402 ENSP00000467239 ENSP00000463854 ENSP00000463003 ENSP00000463834 Reactome Protein details: P45985 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing MAP2K4 Antibody Products: Assay Products for MAP2K4:
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Protein
Domains /for MAP2K4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P45985 ProtoNet protein and cluster: P45985
UniProtKB/Swiss-Prot: MP2K4_HUMAN, P45985 Domain : The DVD domain (residues 364-387) contains a conserved docking site and is found in the mammalian MAP kinasekinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation Domain : The D domain (residues 34-52) contains a conserved docking site and is required for the binding to MAPKsubstrates Similarity : Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamilySimilarity : Contains 1 protein kinase domain
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Functionfor MAP2K4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: MP2K4_HUMAN, P45985 Function : Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transductionpathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14 Catalytic activity : ATP + a protein = ADP + a phosphoproteinEnzyme regulation : Activated in response to a variety of cellular stresses, including UV and gamma-irradiation, heatshock, hyperosmolarity, T-cell receptor stimulation, peroxide and inflammatory cytokines. Also activated by developmental cues. MAP2K4/MKK4 is activated by the majority of MKKKs, such as MAP3K5/ASK1, MAP3K1/MEKK1, MAP3K7/TAK1, MAP3K10/MLK2, MAP3K11/MLK3, MAP3K12/DLK and MAP3K13/LZK
Genatlas biochemistry entry for MAP2K4 mitogen-activated protein kinase kinase 4,binding to JUN transactivation domain and phosphorylating it,involved in signal transduction,also involved in Ras pathway and hepatogenesis Enzyme Number (IUBMB): EC 2.7.12.2 1 2 Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 6 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MAP2K4 (NM_003010 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAP2K4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MAP2K4
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2K4
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view) : About this table
About GeneDecksing 3 GenomeRNAi human phenotypes for MAP2K4 :Animal Models: Map2k4 tm1Flv Map2k4 tm1Liz Map2k4 tm1Pngr 10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Map2k4) :About GeneDecksing
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Pathways & Interactionsfor MAP2K4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/93 super-pathways (see all 93 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 TRAF6 Mediated Induction of proinflammatory cytokines 2 Development HGF signaling pathway 3 ErbB4 Pathway 4 4-1BB Pathway 5 TWEAK Pathway
Pathway sources See GeneCards unified pathways Show all pathways 5/29 (see all 29 )3 5/87 (see all 87 )1 5/30 (see all 30 )5/29 (see all 29 ) 5/25 (see all 25 )2 MAP2K4 5/8 (Kegg details for MAP2K4) (see all 8 ):About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP2K4 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/607 Interacting proteins for MAP2K4 (P45985 1 , 2 , 3 ENSP00000262445 4 via UniProtKB, MINT, STRING , and/or I2D (see all 607 )Interactant Interaction Details GeneCard External ID(s) MAP3K1 Q13233 1 , 3 ENSP00000382423 4 EBI-447868,EBI-49776 I2D:
score=8 STRING: ENSP00000382423 ARRB2 P32121 2 , 3 ENSP00000269260 4 MINT-7263286 I2D:
score=3 STRING: ENSP00000269260 MAP2K7 O14733 2 , 3 ENSP00000381066 4 MINT-7947479 I2D:
score=2 STRING: ENSP00000381066 ARRB1 P49407 2 , 3 ENSP00000377141 4 MINT-7263269 I2D:
score=1 STRING: ENSP00000377141 CFLAR O15519 2 , 3 ENSP00000312455 4 MINT-3391445 I2D:
score=1 STRING: ENSP00000312455
About this table Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000165 MAPK cascade
-- -- GO:0002224 toll-like receptor signaling pathway
TAS -- GO:0002755 MyD88-dependent toll-like receptor signaling pathway
TAS -- GO:0002756 MyD88-independent toll-like receptor signaling pathway
TAS -- GO:0006468 protein phosphorylation
-- --
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Drugs & Compoundsfor MAP2K4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for MAP2K4 2 HMDB Compounds for MAP2K4 About this table 10/36 Novoseek chemical compound relationships for MAP2K4 gene (see all 36 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
anisomycin
77.7
3
9295340 (1), 16802349 (1), 17699104 (1)
sp 600125
73.9
5
17085668 (2), 16601071 (1), 15040011 (1), 16300886 (1)
sb 203580
61
1
11118445 (1)
rottlerin
50.7
1
11314034 (1)
threonine
45.2
5
20156194 (2), 11062067 (2), 9516438 (1)
pd 98,059
40.6
2
11483663 (1), 10843986 (1)
12-o-tetradecanoylphorbol 13-acetate
37.6
7
9858570 (2), 9733728 (1), 18234971 (1), 10807930 (1)
tyrosine
36
15
11062067 (3), 20156194 (2), 9890951 (2), 10713072 (1) (see all 7 )
4-hydroxynonenal
33.8
6
10953046 (2), 11306108 (2), 19248828 (1), 18276794 (1)
ly294002
30.4
2
11707464 (1), 16115952 (1)
MAP2K4 / MP2K4
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Transcriptsfor MAP2K4 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MAP2K4 gene: NM_003010.2 Unigene Cluster for MAP2K4:
Mitogen-activated protein kinase kinase 4 Hs.514681 [show with all ESTs ] Unigene Representative Sequence: AK131544 10 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000353533 (uc002gnj.3 uc010vvi.2 uc010vvj.2 ) ENST00000582183 ENST00000415385 (uc002gnk.3 ) ENST00000538465 ENST00000582897 ENST00000581941 ENST00000579089 ENST00000582377 ENST00000585076 ENST00000536413 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 6 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MAP2K4 (NM_003010 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAP2K4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MAP2K4
Additional cDNA sequence: AK122997.1 AK131544.1 AK294923.1 AK313053.1 AK316100.1 AK316177.1 BC036032.1 BC050386.1 BC060764.1 BT019676.1 CR536564.1 L31902.1 L36870.1 U17743.1
17 DOTS entries : DT.101981454 DT.91746360
DT.100781239 DT.95113864 DT.97781931 DT.121295112 DT.100781235 DT.120996705 DT.91746362 DT.91746373 DT.91964505 DT.100025254 DT.100781234 DT.120996710 DT.120996738 DT.120996759 DT.91746365 24/191 AceView cDNA sequences (see all 191 ):
AW148655 BE907571 T70269 AI147099 CR600508 C02290 CR601866 BP377803 BC036032 BQ688882 BM835007 BQ688042 AI347169 AU139238 BQ690937 AA810268 AA258067 AK122997 Z44430 R93057 T16655 CR536564 BC050386 Z40358 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K4 (see all 6 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c SP1 : - - - SP2 : - - - - SP3 : - - SP4 : - - - - SP5 :
ECgene alternative splicing isoforms for MAP2K4
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Expression for MAP2K4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MAP2K4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GAATCGAAGT
About this image MAP2K4 expression in embryonic tissues and stem cells About this table 1 LifeMap In Vivo Development Anatomical Compartment/CellTissue Category (developmental path) Liver Liver Bud Hepatoblasts Liver Expression: Experimental details:
In-situ hybridization
See MAP2K4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MAP2K4 SOURCE GeneReport for Unigene cluster: Hs.514681 UniProtKB/Swiss-Prot: MP2K4_HUMAN, P45985 Tissue specificity : Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissuesSABiosciences Expression via Pathway-Focused PCR Arrays including MAP2K4 (see all 7 ): Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2K4
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Orthologsfor MAP2K4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for MAP2K4 gene from 9/32 species (see all 32 ) About this table
ENSEMBL Gene Tree for MAP2K4 (if available)TreeFam Gene Tree for MAP2K4 (if available)
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Paralogsfor MAP2K4 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MAP2K4 gene MAP2K3 2 MAP2K5 2 MAP2K2 2 MAP2K6 2 MAP2K7 2 MAP2K1 2 18/19 SIMAP similar genes for MAP2K4 using alignment to 6 protein entries: MP2K4_HUMAN (see all proteins )
(see all similar genes ):MAP2K6 DKFZp686N0154 STK38L MAP2K3 MAP2K7 PHKG2 MAP2K5 STK25 DKFZp686L02273 MAPK3 MAP2K2 RPS6KA2 RPS6KA1 STK3 STK4 MAP2K1 MAP4K1 MAP4K5 About GeneDecksing 1 Pseudogenes.org Pseudogene for MAP2K4 PGOHUM00000241393
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Genomic Variantsfor MAP2K4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 17 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for MAP2K4 (11924135 - 12047147 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for MAP2K4 3 CNVs 77519 88344 72795 Human Gene Mutation Database (HGMD) : MAP2K4 4 SABiosciences Cancer Mutation PCR Assays for MAP2K4 :
1 SABiosciences qBiomarker Copy Number PCR Array containing MAP2K4 :
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor MAP2K4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 601335
OMIM disorders : --20/52 (see all 52 ): About MalaCards spastic paraplegia hereditary spastic paraplegia laryngeal squamous cell carcinoma paraplegia squamous cell carcinoma pancreatic endocrine tumors cytomegalovirus infection spasticity chronic lymphocytic leukemia acute myeloid leukemia huntington's disease lymphocytic leukemia myeloid leukemia malignant glioma carcinoma sjogren's syndrome chagas disease ovarian carcinoma embryonal carcinoma prostate cancer 1 disease from the University of Copenhagen DISEASES database for MAP2K4 :Cancer 10/21 Novoseek disease relationships for MAP2K4 gene (see all 21 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
pancreatic carcinoma
44.4
5
15623633 (2), 9331070 (1), 9622070 (1)
metastasis
26.1
28
12650604 (3), 16489030 (3), 18337456 (2), 15623633 (2) (see all 14 )
tumors
22.4
30
9622070 (4), 11754110 (3), 17276500 (3), 17577251 (2) (see all 12 )
prostate cancer
22.3
19
11306453 (5), 17577251 (4), 18337456 (2), 19638505 (2) (see all 5 )
anthrax
20
2
15843553 (1), 12788955 (1)
ovarian cancer
14.6
14
17276500 (3), 12438272 (3), 10075725 (1), 16489030 (1) (see all 6 )
ovarian carcinoma
13.4
3
9926932 (1), 16489030 (1)
cancer
11.9
17
16492916 (2), 19610067 (2), 16740690 (2), 9331070 (1) (see all 10 )
shock
11.4
1
10082520 (1)
allelic loss
9.45
4
12376211 (1), 11306453 (1)
Human Genome Epidemiology (HuGE) Navigator: MAP2K4 (6 documents) Export disorders for MAP2K4 gene to outside databases
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Publicationsfor MAP2K4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MAP2K4 gene, integrated from 9 sources (see all 380 ):(articles sorted by number of sources associating them with MAP2K4) Utopia : connect your pdf to the dynamic
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. (PubMed id 7716521) 1 , 2 , 3(1995) Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. (PubMed id 9622070) 1 , 2 , 9(1998) A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates. (PubMed id 12788955) 1 , 2 , 9(2003) Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. (PubMed id 7839144) 1 , 2 , 9(1995) Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition st ate. (PubMed id 20732303) 1 , 2 (2010) Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases. (PubMed id 15866172) 1 , 2 (2005) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 (2004) Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade. (PubMed id 12189133) 1 , 2 (2002) Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. (PubMed id 11090355) 1 , 2 (2000) Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor. (PubMed id 11104681) 1 , 2 (2000)
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External Searches for MAP2K4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MAP2K4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing MAP2K4 gene
(According to HUGE )
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Specialized Databases showing MAP2K4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for MAP2K4 gene: MAP2K4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MAP2K4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for MAP2K4 OriGene shRNA RFP for MAP2K4 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for MAP2K4 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MAP2K4 OriGene 3'-UTR Clone for MAP2K4 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for MAP2K4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MAP2K4 OriGene Custom Protein Services for MAP2K4 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAP2K4 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP2K4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for MAP2K4 (MKK4)
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MAP2K4 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2K4
ThermoFisher Antibody for MAP2K4
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MAP2K4
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and Proteopedia 
for MAP2K4:
Kegg Pathways 
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Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
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