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MAP2K4 Gene

protein-coding GIFtS: 66

GC17P011864

mitogen-activated protein kinase kinase 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SERK1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.12.2 ^³
JNKK ^², ³
JNKK1 ^¹, ², ³
MAPKK4 ^²
MEK4 ^¹, ²
MKK4 ^¹, ², ³
PRKMK4 ^¹, ², ³
SEK1 ^², ³
SERK1 ^², ³

Descriptions
JNK activating kinase 1 ^²
JNK-activated kinase 1 ^²
JNK-activating kinase 1 ^³
MAP kinase kinase 4 ^², ³
MAPK/ERK kinase 4 ^²
SAPK/ERK kinase 1 ^², ³
c-Jun N-terminal kinase kinase 1 ^², ³
dual specificity mitogen-activated protein kinase kinase 4 ^²
mitogen-activated protein kinase kinase 4 ^²

External Ids
HGNC: 6844¹
Entrez Gene: 6416²
UniProtKB: P45985³
Ensembl: ENSG00000065559⁷

Search outside databases for aliases for MAP2K4 gene

Previous GC identifers: GC17P012290 GC17P013039 GC17P011868 GC17P012124

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for MAP2K4:

This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase

family. This kinase is a direct activator of MAP kinases in response to various environmental

stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and

MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by

MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival

signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq]

UniProtKB/Swiss-Prot: MP2K4_HUMAN, P45985

Function: Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as

well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1)

Gene Wiki entry for MAP2K4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MAP2K4 gene

Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p12 HGNC cytogenetic band: 17p11.2

MAP2K4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P011864: (about GC identifiers)

Start:	11,864,860 bp from pter
End:	11,987,865 bp from pter
Size:	123,006 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MP2K4_HUMAN, P45985 (See protein sequence)

Recommended Name: Dual specificity mitogen-activated protein kinase kinase 4

Size: 399 amino acids; 44288 Da

Subunit: Interacts with SPAG9 (By similarity)

Secondary accessions: Q5U0B8

Post-translational modifications:

Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases (By similarity)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003001.1

ENSEMBL proteins:

ENSP00000262445

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant MAP2K4 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for MAP2K4 (MKK4)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MEK4)
	Human Recombinant Proteins from Abnova (MAP2K4)

OriGene Purified Recombinant Human Protein: MAP2K4

Antibodies for MAP2K4:

	Invitrogen Antibodies for MAP2K4
	Millipore Mono- and Polyclonal Antibodies for the study of MAP2K4
	Sigma-Aldrich Antibody Arrays and Antibodies for MAP2K4
	R&D Systems Antibodies for MAP2K4 (MKK4)
	Cell Signaling Technology (CST) Antibodies for MAP2K4 (MKK4, SEK1/MKK4)
	Antibodies from Abcam (MEK4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MAP2K4)
	Novus Biologicals Antibodies for MAP2K4

Assays for MAP2K4:

	Invitrogen Assays for MAP2K4
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P45985

ProtoNet protein and cluster: P45985

UniProtKB/Swiss-Prot: MP2K4_HUMAN, P45985

Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP

kinase kinase subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAP2K4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MAP2K4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003010

Applied Biosystems Silencer® siRNAs for MAP2K4

Sigma-Aldrich siRNA and siRNA Panels for MAP2K4

Sigma-Aldrich shRNA Panels and shRNA for MAP2K4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MAP2K4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003010
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003010
untagged cDNA clones in CMV expression vector (see all 6): NM_003010

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003010

UniProtKB/Swiss-Prot: MP2K4_HUMAN, P45985

Function: Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as

well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1)

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.12.2

Genatlas biochemistry entry for MAP2K4:

mitogen-activated protein kinase kinase 4,binding to JUN transactivation domain and phosphorylating

it,involved in signal transduction,also involved in Ras pathway and hepatogenesis

9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Map2k4):

	behavior/neurological	growth/size	hematopoietic system	lethality-postnatal
lethality-prenatal/perinatal	liver/biliary system	nervous system	normal

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0004713	protein tyrosine kinase activity	IEA	--
GO:0005515	protein binding	IPI	9808624 15299019 16533805
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/64 Sigma-Aldrich "Your Favorite Gene" Pathways for MAP2K4 (Your Favorite Gene powered by Ingenuity) (see all 64 )

FXR/RXR Activation
IL-17 Signaling
SAPK/JNK Signaling
EGF Signaling
Melatonin Signaling

GeneDecks MAP2K4 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for MAP2K4

5/99 Interacting proteins for MAP2K4 (P45985^{1, 2} ENSP00000262445³) via UniProtKB, MINT, and/or STRING (see all 99 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAPK8	P45983¹, ENSP00000363291³	EBI-447868, EBI-286483 STRING (score=.999)
TRIB1	Q96RU8¹, ENSP00000312150³	EBI-447868, EBI-492555 STRING (score=.711)
MAP3K1	Q13233¹	EBI-447868, EBI-49776
MAPK8IP3	ENSP00000250894³	STRING (score=.998)
PPM1A	ENSP00000327255³	STRING (score=.993)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	IEA	--
GO:0007165	signal transduction	TAS	7716521
GO:0007254	JNK cascade	TAS	7716521

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for MAP2K4:

Inhibitor

Browse Tocris compounds for MAP2K4
10/18 Novoseek chemical compound relationships for MAP2K4 gene (see all 18 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sp 600125	74.61	5	17085668 (2), 16601071 (1), 15040011 (1), 16300886 (1)
threonine	44.91	3	11062067 (2), 9516438 (1)
12-o-tetradecanoylphorbol 13-acetate	38.52	7	9858570 (2), 9733728 (1), 18234971 (1), 10807930 (1)
pd 98,059	38.46	2	11483663 (1), 10843986 (1)
tyrosine	36.36	13	11062067 (3), 9890951 (2), 10713072 (1), 11053415 (1) (see all 6)
sodium orthovanadate	26.83	1	10807930 (1)
phosphatidylinositol	25.11	2	11707464 (1), 16000309 (1)
wortmannin	21.45	3	17276500 (1), 17251462 (1)
leucine	15.98	1	11416147 (1)
ceramide	11.92	2	15164763 (1), 8662702 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MAP2K4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MAP2K4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003010

Sigma-Aldrich siRNA and siRNA Panels for MAP2K4

Sigma-Aldrich shRNA Panels and shRNA for MAP2K4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003010

REFSEQ mRNAs for MAP2K4 gene:

NM_003010.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003010

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003010
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003010
                                 untagged cDNA clones in CMV expression vector (see all 6): NM_003010

Additional cDNA sequence:

AK122997.1 AK131544.1 AK294923.1 AK313053.1 AK316100.1 AK316177.1 BC036032.1 BC050386.1

BC060764.1 BT019676.1 CR536564.1 CR600508.1 CR601866.1 L31902.1 L36870.1 U17743.1

17 DOTS entries:

DT.101981454 DT.91746360 DT.100781239 DT.95113864 DT.97781931 DT.121295112 DT.100781235 DT.120996705

DT.91746362 DT.91746373 DT.91964505 DT.100025254 DT.100781234 DT.120996710 DT.120996738 DT.120996759

DT.91746365

24/191 AceView cDNA sequences (see all 191 ):

AU140569 BC060764 T70269 BM718928 BQ688042 T16655 R93057 CR536564

BP377803 AI347169 AU137540 AU119785 AI147099 CD246094 AA456831 U17743

AV709279 CR601866 CA503301 Z44789 BU190781 BC050386 BQ688882 AU139238

highest scoring ESTs for MAP2K4:

L36870 U17743 AA278561 AA293050 AA293365 AA383800 AA456831 AA456901 AA468659 AA507800

Unigene Cluster for MAP2K4:

Mitogen-activated protein kinase kinase 4

Hs.514681 [show with all ESTs]

Unigene Representative Sequence: AK131544

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K4 (see all 6 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11	^	12	^	13a	·	13b	·	13c
SP1:							-												-		-
SP2:			-				-												-		-
SP3:																			-		-
SP4:															-				-		-						-
SP5:

About this scheme

ECgene alternative splicing isoforms for MAP2K4

1 Ensembl transcript including schematic representation:

ENST00000353533

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

MAP2K4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MAP2K4

¹ / ² / ³

7 probe-sets matching MAP2K4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36910_at²^{, 3}	U95-A	1	1.00	1.00	0.89	1.31	L36870	1.00	0.90	0.95	1
1845_at²^{, 3}	U95-A	1	1.00	1.00	0.93	1.13	L36870	1.00	0.90	0.95	1
1712_s_at²^{, 3}	U95-A	3	1.00	0.62	0.96	0.61	U17743	1.00	0.90	0.95	1
203266_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003010	0.60	1.00	0.82	1
203265_s_at²^{, 3}	U133-A	2	1.00	0.64	--	--	AA810268	0.80	1.00	0.91	1
203266_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203265_s_at²	U133Plus2	2	1.00	0.64	--	--	--	--	--	--	--

GeneDecks MAP2K4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAATCGAAGT

SOURCE GeneReport for Unigene cluster: Hs.514681
Expression variation in blood from EXPOLDB for MAP2K4
UniProtKB/Swiss-Prot: MP2K4_HUMAN, P45985
Tissue specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed
in other tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MAP2K4 gene from 5/18 species (see all 18 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MAP2K4¹	--	mitogen-activated protein kinase kinase 4	96.4(n) 99.72(a)	489508 XM_546627.2 XP_546627.1
chimpanzee (Pan troglodytes)	MAP2K4¹	--	mitogen-activated protein kinase kinase 4	99.5(n) 99.5(a)	455065 XM_001163981.1 XP_001163981.1
cow (Bos taurus)	MAP2K4¹	--	mitogen-activated protein kinase kinase 4	93.57(n) 99.25(a)	526469 XM_866976.2 XP_872069.2
rat (Rattus norvegicus)	Map2k4¹	--	mitogen activated protein kinase kinase 4	94.46(n) 98.24(a)	287398 NM_001030023.1 NP_001025194.1
mouse (Mus musculus)	Map2k4^{1, 5}	11 (33.00 cM)⁵	mitogen-activated protein kinase kinase 4^{1, 5}	95.21(n)¹ 98.24(a)¹	26398¹ NM_009157.3¹ NP_033183.1¹ AK036928⁵ AK044534⁵ (see all 14)

About this table Species with no ortholog for MAP2K4

ENSEMBL Gene Tree for MAP2K4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MAP2K4 gene

MAP2K3² MAP2K6² MAP2K7²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/715 NCBI SNPs in MAP2K4 are shown (see all 715 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 298)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1870584^1,2	A,C,F,H	11988269(+)	`TCTGGA/GGGTCA`	1	--	ng3¹		9	MN EU EA WA	1024
	rs3826392^1,2	A,C,F,H	11863629(-)	`TACTTA/CAGTGG`	1	--	ng5¹		4	EU EA WA	412
--	rs9892151^1,2	A,C,F	11864845(+)	`GGGGGT/CAAGCC`	1	--	ng5¹		5	NS	184
--	rs4792219^1,2	A,C,F	11986630(+)	`CATTGG/AACCAG`	1	--	ut3¹		5	NS	168
	rs3809728^1,2	C,F	11863889(-)	`GGACAT/ATTTCT`	1	--	ng5¹		6	EA NS	1492
--	rs2190853^1,2	C,F	11864292(+)	`GCATAC/GAAATT`	1	--	ng5¹ tfbs³		5	NS	166
--	rs28921113^1,2	F	11986018(+)	`GTCCTA/GTTTTT`	1	--	ut3¹		5	NS	134
--	rs28918076^1,2	F	11864734(+)	`CCCAGA/CGCCGG`	1	--	ng5¹		5	NS	182
--	rs11555725^1,2	C	11986068(-)	`AGGATC/GAGCAC`	1	--	ut3¹ ese³		5	NS	124
--	rs28918075^1,2	F	11864701(+)	`CCAAG-/CAAG ACAGC`	1	--	ng5¹		5	NS	176

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HapMap Linkage Disequilibrium images for MAP2K4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601335

10/21 Novoseek disease relationships for MAP2K4 gene (see all 21 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pancreatic carcinoma	37.73	5	15623633 (2), 9331070 (1), 9622070 (1)
metastasis	25.55	27	12650604 (3), 16489030 (3), 18337456 (2), 15623633 (2) (see all 13)
tumors	23.83	23	9622070 (4), 11754110 (3), 17276500 (3), 17577251 (2) (see all 11)
anthrax	21.97	2	15843553 (1), 12788955 (1)
prostate cancer	19.36	17	11306453 (5), 17577251 (4), 18337456 (2), 14613661 (1)
ovarian cancer	16.75	14	17276500 (3), 12438272 (3), 10075725 (1), 16489030 (1) (see all 6)
ovarian carcinoma	14.95	3	9926932 (1), 16489030 (1)
cancer	10.64	15	16492916 (2), 16740690 (2), 9331070 (1), 18337456 (1) (see all 9)
allelic loss	10.36	4	12376211 (1), 11306453 (1)
shock	9.77	1	10082520 (1)

About this table

Human Genome Epidemiology Navigator: MAP2K4 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/323 PubMed articles for MAP2K4 gene (see all 323 ):

Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. (PubMed id 7716521)^{2, 3, 4} Lin A.... Karin M. (1995)
Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. (PubMed id 9622070)^{1, 3, 4} Su G.H....Kern S.E. (1998)
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. (PubMed id 7839144)^{1, 3, 4} Derijard B.... Davis R.J. (1995)
Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor. (PubMed id 11104681)^{3, 4} Vitale G.... Montecucco C. (2000)
MAP2K4/MKK4 expression in pancreatic cancer: genetic validation of immunohistochemistry and relationship to disease course. (PubMed id 15623633)^{1, 3} Xin W....Iacobuzio-Donahue C.A. (2004)
Mitogen-activated protein kinase kinase 4/c-Jun NH2-terminal kinase kinase 1 protein expression is subject to translational regulation in prostate cancer cell lines. (PubMed id 18337456)^{1, 3} Robinson V.L....Rinker-Schaeffer C.W. (2008)
Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers. (PubMed id 11306453)^{1, 3} Kim H.L....Rinker-Schaeffer C.W. (2001)
Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK. (PubMed id 13130464)^{1, 3} Sundarrajan M....Firestein G.S. (2003)
Akt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylation. (PubMed id 11707464)^{1, 3} Park H.S....Choi E.J. (2002)
Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases. (PubMed id 18713996)^{1, 3} Yoshizawa T....Firestein G.S. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6416	HGNC: 6844	AceView: MAP2K4	Ensembl:ENSG00000065559	euGenes: HUgn6416
ECgene: MAP2K4	H-InvDB: MAP2K4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MAP2K4	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/map2k4/

Licensable Technologies for MAP2K4
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for MAP2K4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MAP2K4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MAP2K4		Antibodies for MAP2K4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MAP2K4		Small molecules for MAP2K4
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (MAP2K4)
	Antibodies (MAP2K4)
	Chimera RNAi (MAP2K4)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for MAP2K4 (MKK4, SEK1/MKK4)

	Recombinant Proteins (MEK4)
	Antibodies (MEK4)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for MAP2K4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for MAP2K4

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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MAP2K4 Gene at Home site.
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MAP2K4 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for MAP2K4

Summaries
for MAP2K4

Genomic Location
for MAP2K4

Proteins
for MAP2K4

Protein Domains/
Families
for MAP2K4

Gene Function
for MAP2K4

Pathways & Interactions
for MAP2K4

Drugs & Compounds
for MAP2K4

Transcripts
for MAP2K4

Expression
for MAP2K4

Orthologs
for MAP2K4

Paralogs
for MAP2K4

SNPs/Variants
for MAP2K4

Disorders & Mutations
for MAP2K4

Medical News
for MAP2K4

Publications
for MAP2K4

Search for MAP2K4

Genome Databases showing MAP2K4

Other Databases showing MAP2K4

Specialized Databases showing MAP2K4

Licensable Technologies
for MAP2K4

Services
for MAP2K4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MAP2K4 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor MAP2K4

Summariesfor MAP2K4

Genomic Locationfor MAP2K4

Proteinsfor MAP2K4

Protein Domains/Familiesfor MAP2K4

Gene Functionfor MAP2K4

Pathways & Interactionsfor MAP2K4

Drugs & Compoundsfor MAP2K4

Transcriptsfor MAP2K4

Expression for MAP2K4

Orthologsfor MAP2K4

Paralogsfor MAP2K4

SNPs/Variantsfor MAP2K4

Disorders & Mutationsfor MAP2K4

Medical Newsfor MAP2K4

Publicationsfor MAP2K4

Search for MAP2K4

Genome Databases showing MAP2K4

Other Databases showing MAP2K4

Specialized Databases showing MAP2K4

Licensable Technologiesfor MAP2K4

Servicesfor MAP2K4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MAP2K4

Summaries
for MAP2K4

Genomic Location
for MAP2K4

Proteins
for MAP2K4

Protein Domains/
Families
for MAP2K4

Gene Function
for MAP2K4

Pathways & Interactions
for MAP2K4

Drugs & Compounds
for MAP2K4

Transcripts
for MAP2K4

Expression
for MAP2K4

Orthologs
for MAP2K4

Paralogs
for MAP2K4

SNPs/Variants
for MAP2K4

Disorders & Mutations
for MAP2K4

Medical News
for MAP2K4

Publications
for MAP2K4

Licensable Technologies
for MAP2K4

Services
for MAP2K4