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Aliases for MAP2K3 Gene

Aliases for MAP2K3 Gene

  • Mitogen-Activated Protein Kinase Kinase 3 2 3
  • MAP Kinase Kinase 3 2 3 4
  • MAPK/ERK Kinase 3 2 3 4
  • PRKMK3 3 4 6
  • MEK3 3 4 6
  • Stress-Activated Protein Kinase Kinase 2 3 4
  • SAPK Kinase 2 3 4
  • EC 2.7.12.2 4 64
  • MAPKK 3 3 4
  • SAPKK-2 3 4
  • MAPKK3 3 6
  • SAPKK2 3 4
  • MEK 3 3 4
  • MKK3 3 4
  • Dual Specificity Mitogen Activated Protein Kinase Kinase 3 2
  • Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 3
  • SKK2 4

External Ids for MAP2K3 Gene

Previous Symbols for MAP2K3 Gene

  • PRKMK3

Summaries for MAP2K3 Gene

Entrez Gene Summary for MAP2K3 Gene

  • The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP2K3 Gene

MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and GPCR Pathway. GO annotations related to this gene include protein serine/threonine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is MAP2K7.

UniProtKB/Swiss-Prot for MAP2K3 Gene

  • Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38

Gene Wiki entry for MAP2K3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP2K3 Gene

Genomics for MAP2K3 Gene

Genomic Location for MAP2K3 Gene

Start:
21,284,656 bp from pter
End:
21,315,240 bp from pter
Size:
30,585 bases
Orientation:
Plus strand

Genomic View for MAP2K3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP2K3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP2K3 Gene

Regulatory Elements for MAP2K3 Gene

Transcription factor binding sites by QIAGEN in the MAP2K3 gene promoter:

Proteins for MAP2K3 Gene

  • Protein details for MAP2K3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46734-MP2K3_HUMAN
    Recommended name:
    Dual specificity mitogen-activated protein kinase kinase 3
    Protein Accession:
    P46734
    Secondary Accessions:
    • B3KSK7
    • Q99441
    • Q9UE71
    • Q9UE72

    Protein attributes for MAP2K3 Gene

    Size:
    347 amino acids
    Molecular mass:
    39318 Da
    Quaternary structure:
    • Binds to DYRK1B/MIRK and increases its kinase activity. Part of a complex with MAP3K3, RAC1 and CCM2. Interacts with ARRB1. Interacts with Yersinia yopJ.

    Alternative splice isoforms for MAP2K3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP2K3 Gene

Proteomics data for MAP2K3 Gene at MOPED

Post-translational modifications for MAP2K3 Gene

  • Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity. Phosphorylated by TAOK2.
  • Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys183 and Lys243

Domains for MAP2K3 Gene

Gene Families for MAP2K3 Gene

HGNC:
  • MAP2K :Mitogen-activated protein kinase cascade / Kinase kinases
IUPHAR :

UniProtKB/Swiss-Prot:

MP2K3_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • P46734
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.:
    • P46734
genes like me logo Genes that share domains with MAP2K3: view

Function for MAP2K3 Gene

Molecular function for MAP2K3 Gene

GENATLAS Biochemistry: mitogen-activated protein kinase kinase 3,critical component of TNF-stimulated signaling pathway that causes increased expression of inflammatory cytokines
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by dual phosphorylation on Ser-218 and Thr-222
UniProtKB/Swiss-Prot Function: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38

Enzyme Numbers (IUBMB) for MAP2K3 Gene

Gene Ontology (GO) - Molecular Function for MAP2K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004702 receptor signaling protein serine/threonine kinase activity IBA --
GO:0004708 MAP kinase kinase activity IBA --
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with MAP2K3: view
genes like me logo Genes that share phenotypes with MAP2K3: view

Animal Models for MAP2K3 Gene

MGI Knock Outs for MAP2K3:

miRNA for MAP2K3 Gene

miRTarBase miRNAs that target MAP2K3

No data available for Transcription Factor Targeting and HOMER Transcription for MAP2K3 Gene

Localization for MAP2K3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP2K3 Gene COMPARTMENTS Subcellular localization image for MAP2K3 gene
Compartment Confidence
cytosol 4
nucleus 4
extracellular 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MAP2K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with MAP2K3: view

Pathways for MAP2K3 Gene

genes like me logo Genes that share pathways with MAP2K3: view

Gene Ontology (GO) - Biological Process for MAP2K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade --
GO:0000187 activation of MAPK activity TAS --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with MAP2K3: view

Compounds for MAP2K3 Gene

(2) HMDB Compounds for MAP2K3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(10) Novoseek inferred chemical compound relationships for MAP2K3 Gene

Compound -log(P) Hits PubMed IDs
sb 203580 81.8 7
anisomycin 73.7 2
mannitol 38.2 3
tyrosine 32.3 3
arsenite 30.2 1
genes like me logo Genes that share compounds with MAP2K3: view

Transcripts for MAP2K3 Gene

Unigene Clusters for MAP2K3 Gene

Mitogen-activated protein kinase kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c
SP1: - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: -
SP8:
SP9: -

Relevant External Links for MAP2K3 Gene

GeneLoc Exon Structure for
MAP2K3
ECgene alternative splicing isoforms for
MAP2K3

Expression for MAP2K3 Gene

mRNA expression in normal human tissues for MAP2K3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP2K3 Gene

This gene is overexpressed in Whole Blood (10.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP2K3 Gene

SOURCE GeneReport for Unigene cluster for MAP2K3 Gene Hs.514012

mRNA Expression by UniProt/SwissProt for MAP2K3 Gene

P46734-MP2K3_HUMAN
Tissue specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues
genes like me logo Genes that share expressions with MAP2K3: view

Orthologs for MAP2K3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP2K3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 95 (a)
OneToMany
MAP2K3 36
  • 99.62 (n)
  • 100 (a)
MAP2K3 37
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MAP2K3 36
  • 90.78 (n)
  • 96.54 (a)
MAP2K3 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP2K3 36
  • 92.03 (n)
  • 99.14 (a)
MAP2K3 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map2k3 36
  • 90.59 (n)
  • 96.54 (a)
Map2k3 16
Map2k3 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP2K3 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP2K3 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911550 36
  • 89.91 (n)
  • 96.54 (a)
chicken
(Gallus gallus)
Aves MAP2K3 36
  • 82.83 (n)
  • 91.16 (a)
MAP2K3 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP2K3 37
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000310 36
  • 67.21 (n)
  • 64.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta lic 36
  • 63.47 (n)
  • 62.58 (a)
lic 37
  • 59 (a)
OneToMany
lic 38
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea sek-1 37
  • 50 (a)
OneToMany
F35C8.1 38
  • 33 (a)
VZC374L.1 38
  • 45 (a)
sek-1 38
  • 51 (a)
jkk-1 38
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3213 37
  • 60 (a)
OneToMany
Species with no ortholog for MAP2K3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MAP2K3 Gene

ENSEMBL:
Gene Tree for MAP2K3 (if available)
TreeFam:
Gene Tree for MAP2K3 (if available)

Paralogs for MAP2K3 Gene

Paralogs for MAP2K3 Gene

genes like me logo Genes that share paralogs with MAP2K3: view

Variants for MAP2K3 Gene

Sequence variations from dbSNP and Humsavar for MAP2K3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs518536 -- 21,283,567(-) GGTCA(C/G)CCCCT upstream-variant-2KB
rs534570 -- 21,311,735(-) CCTTC(C/T)TAACA intron-variant
rs536427 -- 21,292,725(+) caagt(A/G)atcct intron-variant
rs547103 -- 21,283,566(-) GTCAC(C/G)CCCTG upstream-variant-2KB
rs547128 -- 21,283,559(-) CCCTG(C/G)GCTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAP2K3 Gene

Variant ID Type Subtype PubMed ID
nsv907885 CNV Gain 21882294
nsv907886 CNV Loss 21882294
nsv907887 CNV Gain 21882294
nsv907888 CNV Gain 21882294
nsv907889 CNV Gain 21882294
esv2640649 CNV Gain 19546169
nsv511592 CNV Loss 21212237
nsv435679 CNV Deletion 17901297
nsv512480 CNV Loss 21212237
esv2484557 CNV Deletion 19546169
esv2715753 CNV Deletion 23290073

Relevant External Links for MAP2K3 Gene

HapMap Linkage Disequilibrium report
MAP2K3
Human Gene Mutation Database (HGMD)
MAP2K3

Disorders for MAP2K3 Gene

UniProtKB/Swiss-Prot

MP2K3_HUMAN
  • Note=Defects in MAP2K3 may be involved in colon cancer.

(7) Novoseek inferred disease relationships for MAP2K3 Gene

Disease -log(P) Hits PubMed IDs
necrosis 17.6 3
shock 11.7 1
glioma 0 2
osteoarthritis 0 1
rheumatoid arthritis 0 1

Relevant External Links for MAP2K3

Genetic Association Database (GAD)
MAP2K3
Human Genome Epidemiology (HuGE) Navigator
MAP2K3
genes like me logo Genes that share disorders with MAP2K3: view

Publications for MAP2K3 Gene

  1. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. (PMID: 8622669) Raingeaud J. … Davis R.J. (Mol. Cell. Biol. 1996) 3 4 23
  2. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. (PMID: 7839144) Derijard B. … Davis R.J. (Science 1995) 3 4 23
  3. Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases. (PMID: 8226933) Zheng C.F. … Guan K.L. (J. Biol. Chem. 1993) 3 23
  4. Identification and characterization of a predominant isoform of human MKK3. (PMID: 9038352) Han J. … Lin S. (FEBS Lett. 1997) 3 23
  5. Cloning and characterization of MEK6, a novel member of the mitogen- activated protein kinase kinase cascade. (PMID: 8626699) Stein B. … Barbosa M.S. (J. Biol. Chem. 1996) 3 23

Products for MAP2K3 Gene

Sources for MAP2K3 Gene

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