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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP2K3 Gene

protein-coding   GIFtS: 73
GCID: GC17P021187

Mitogen-Activated Protein Kinase Kinase 3


(Previous symbol: PRKMK3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitogen-Activated Protein Kinase Kinase 31 2     MAPKK 32 3
PRKMK31 2 3 5     MEK 32 3
MAP Kinase Kinase 31 2 3     SAPK Kinase 22 3
MAPK/ERK Kinase 31 2 3     EC 2.7.12.23 8
MEK32 3 5     MAPKK32 5
Stress-Activated Protein Kinase Kinase 22 3     Dual Specificity Mitogen Activated Protein Kinase Kinase 31
MKK32 3     Dual Specificity Mitogen-Activated Protein Kinase Kinase 32
SAPKK-22 3     SKK23
SAPKK22 3     

External Ids:    HGNC: 68431   Entrez Gene: 56062   Ensembl: ENSG000000341527   OMIM: 6023155   UniProtKB: P467343   

Export aliases for MAP2K3 gene to outside databases

Previous GC identifers: GC17M021362 GC17P022837 GC17P021092 GC17P021350 GC17P021128 GC17P020390


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAP2K3 Gene:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase
family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP
kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be
activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is
found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive
activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is
involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants
that encode distinct isoforms have been reported for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAP2K3 Gene: 
MAP2K3 (mitogen-activated protein kinase kinase 3) is a protein-coding gene. Diseases associated with MAP2K3 include toxoplasmosis, and cytomegalovirus infection, and among its related super-pathways are MAPK Cascade and Immune response TLR signaling pathways. GO annotations related to this gene include protein serine/threonine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is MAP2K5.

UniProtKB/Swiss-Prot: MP2K3_HUMAN, P46734
Function: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the
concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38

Gene Wiki entry for MAP2K3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP2K3 gene promoter:
         AP-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP2K3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP2K3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP2K3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17q11.2

MAP2K3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP2K3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P021187:  view genomic region     (about GC identifiers)

Start:
21,187,968 bp from pter      End:
21,218,552 bp from pter
Size:
30,585 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MP2K3_HUMAN, P46734 (See protein sequence)
Recommended Name: Dual specificity mitogen-activated protein kinase kinase 3  
Size: 347 amino acids; 39318 Da
Subunit: Binds to DYRK1B/MIRK and increases its kinase activity. Part of a complex with MAP3K3, RAC1 and CCM2.
Interacts with ARRB1. Interacts with Yersinia yopJ
Secondary accessions: B3KSK7 Q99441 Q9UE71 Q9UE72
Alternative splicing: 3 isoforms:  P46734-1   P46734-2   P46734-3   

Explore the universe of human proteins at neXtProt for MAP2K3: NX_P46734

Explore proteomics data for MAP2K3 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the
    kinase activity. Phosphorylated by TAOK2
  • UniProtKB: Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK
    signaling pathway
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P46734

  • 4/7 DME Specific Peptides for MAP2K3 (P46734) (see all 7)
     WICMELM  AILRFPY  FYGALFREGD  IMAVKRIRATVN 

    MAP2K3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAP2K3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002747.2  NP_659731.1  

    ENSEMBL proteins: 
     ENSP00000378869   ENSP00000345083   ENSP00000431203   ENSP00000463202   ENSP00000463417  
     ENSP00000464043   ENSP00000434068   ENSP00000319139   ENSP00000462178   ENSP00000355081  
    Reactome Protein details: P46734
    Human Recombinant Protein Products for MAP2K3: 
    EMD Millipore Purified and/or Recombinant MAP2K3 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for MAP2K3
    OriGene Protein Over-expression Lysate for MAP2K3
    OriGene MassSpec for MAP2K3 
    OriGene Custom Protein Services for MAP2K3
    GenScript Custom Purified and Recombinant Proteins Services for MAP2K3
    Novus Biologicals MAP2K3 Proteins
    Novus Biologicals MAP2K3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MAP2K3
    Cloud-Clone Corp. Proteins for MAP2K3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--

    MAP2K3 for ontologies           About GeneDecksing



    MAP2K3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP2K3
    R&D Systems Antibodies for MAP2K3 (MKK3)
    Cell Signaling Technology (CST) Antibodies for MAP2K3  (MKK3)
    OriGene Antibodies for MAP2K3
    OriGene Custom Antibody Services for MAP2K3
    GenScript Custom Superior Antibodies Services for MAP2K3
    Novus Biologicals MAP2K3 Antibodies
    Abcam antibodies for MAP2K3
    Cloud-Clone Corp. Antibodies for MAP2K3 
    ThermoFisher Antibody for MAP2K3
    LSBio Antibodies in human, mouse, rat for MAP2K3 

    Assay Products for MAP2K3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAP2K3
    R&D Systems ELISAs for MAP2K3 (MKK3)         (see all)
    GenScript Custom Assay Services for MAP2K3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAP2K3 
    Cloud-Clone Corp. CLIAs for MAP2K3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MAP2K: Mitogen-activated protein kinase cascade / Kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase 3 
    STE7 family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P46734

    ProtoNet protein and cluster: P46734

    UniProtKB/Swiss-Prot: MP2K3_HUMAN, P46734
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain


    MAP2K3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MP2K3_HUMAN, P46734
    Function: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the
    concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by dual phosphorylation on Ser-218 and Thr-222

         Genatlas biochemistry entry for MAP2K3:
    mitogen-activated protein kinase kinase 3,critical component of TNF-stimulated signaling pathway that causes
    increased expression of inflammatory cytokines

         Enzyme Number (IUBMB): EC 2.7.12.21 2

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004708MAP kinase kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI11980910
         
    MAP2K3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MAP2K3:
     Decreased influenza A/WSN/33 r  Decreased substrate adherent c  Decreased viability 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Map2k3):
     cellular  immune system  mortality/aging 

    MAP2K3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Map2k3tm1Flv for MAP2K3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAP2K3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAP2K3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP2K3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP2K3 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAP2K3:
    hsa-mir-214 (MIRT005426)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP2K3
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP2K3 (see all 15):
    hsa-miR-3120-3p hsa-miR-1271 hsa-miR-486-3p hsa-miR-21 hsa-miR-4298 hsa-miR-590-5p hsa-miR-1302 hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmidMAP2K3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAP2K3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP2K3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAP2K3
    Sirion Biotech Customized adenovirus for overexpression of MAP2K3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MAP2K3 (see all 13)
    OriGene ORF clones in mouse, rat for MAP2K3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MAP2K3 (NM_145109)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP2K3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP2K3
    Sirion Biotech Customized lentivirus for stable overexpression of MAP2K3 
                         Customized lentivirus expression plasmids for stable overexpression of MAP2K3 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MAP2K3
    Search LifeMap BioReagents cell lines for MAP2K3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2K3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAP2K3 About   (see all 85)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1G-protein signaling Ras family GTPases in kinase cascades (scheme)
    G-protein signaling Ras family GTPases in kinase cascades (scheme)0.44
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    MAPK Cascade0.44
    2Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response
    Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response0.94
    Immune response TLR signaling pathways0.94
    3Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.93
    4Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.45
    Fc epsilon RI signaling pathway0.40
    5Toll Comparative Pathway
    Immune response IL-1 signaling pathway0.41
    IL-1 Pathway0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/18 EMD Millipore Pathways for MAP2K3 (see all 18)
        Development A1 receptor signaling
    Development TGF-beta receptor signaling
    G-protein signaling Ras family GTPases in kinase cascades (scheme)
    Immune response IL-1 signaling pathway
    Transcription PPAR Pathway

    4 R&D Systems Pathways for MAP2K3
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    Toll-Like receptor Signaling Pathways
    TGF-beta Signaling Pathways

    5/78 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP2K3 (see all 78)
        Toll-Like Receptors Pathway
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    PACAP Signaling
    Rho Family GTPases

    1 Cell Signaling Technology (CST) Pathway for MAP2K3
        MAP Kinase Signaling

    5/21 GeneGo (Thomson Reuters) Pathways for MAP2K3 (see all 21)
        G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Transcription PPAR Pathway
    Immune response IL-12-induced IFN-gamma production
    Development TGF-beta receptor signaling
    Mucin expression in CF via TLRs, EGFR signaling pathways

    5/23 BioSystems Pathways for MAP2K3 (see all 23)
        Focal Adhesion
    MicroRNAs in cardiomyocyte hypertrophy
    Senescence and Autophagy
    EGFR1 Signaling Pathway
    Insulin Signaling

    5/22        Reactome Pathways for MAP2K3 (see all 22)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll-Like Receptors Cascades
    TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 7/8 (TLR7/8) Cascade

    2 PharmGKB Pathways for MAP2K3
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    5/9         Kegg Pathways  (Kegg details for MAP2K3) (see all 9):
        MAPK signaling pathway
    Toll-like receptor signaling pathway
    Fc epsilon RI signaling pathway
    TNF signaling pathway
    GnRH signaling pathway


    MAP2K3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP2K3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/653 Interacting proteins for MAP2K3 (P467341, 2, 3 ENSP000003450834) via UniProtKB, MINT, STRING, and/or I2D (see all 653)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL13P263732, 3, ENSP000003078894MINT-7945693 MINT-8259833 I2D: score=2 STRING: ENSP00000307889
    DYRK1BQ9Y4631, 3, ENSP000003127894EBI-602462,EBI-634187 I2D: score=2 STRING: ENSP00000312789
    DCTN1Q142032, 3, ENSP000003547914MINT-7945693 I2D: score=1 STRING: ENSP00000354791
    MAPK14Q165392, 3, ENSP000002297944MINT-4300259 I2D: score=3 STRING: ENSP00000229794
    MAP3K5Q996831, 3, ENSP000003519084EBI-602462,EBI-476263 I2D: score=1 STRING: ENSP00000351908
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade ----
    GO:0000187activation of MAPK activity TAS--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--

    MAP2K3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP2K3 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAP2K3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP2K3 (MP2K3)

    2 HMDB Compounds for MAP2K3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    10 Novoseek inferred chemical compound relationships for MAP2K3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sb 203580 81.8 7 15797859 (2), 11546797 (1), 10586114 (1), 10960075 (1) (see all 6)
    anisomycin 73.7 2 11259586 (1), 20004242 (1)
    mannitol 38.2 3 10842172 (1), 17438131 (1), 11078444 (1)
    tyrosine 32.3 3 11304531 (1), 15797859 (1), 11062067 (1)
    arsenite 30.2 1 11259586 (1)
    okadaic acid 28.3 3 18299321 (2), 10960075 (1)
    serine 16.2 2 10606930 (2)
    nitric oxide 0 3 16097952 (1), 19567397 (1)
    glucose 0 3 11546797 (1), 11279172 (1)
    calcium 0 1 15180997 (1)

    Search CenterWatch for drugs/clinical trials and news about MAP2K3 / MP2K3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAP2K3 gene (3 alternative transcripts): 
    NM_002756.4  NM_145109.2  NM_145110.1  

    Unigene Cluster for MAP2K3:

    Mitogen-activated protein kinase kinase 3
    Hs.514012  [show with all ESTs]
    Unigene Representative Sequence: AK093838
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395491(uc002gyt.3 uc021tsr.1) ENST00000342679(uc002gys.3)
    ENST00000534743 ENST00000529517 ENST00000483928 ENST00000479129 ENST00000583508
    ENST00000496046 ENST00000526076 ENST00000316920 ENST00000477540 ENST00000527123
    ENST00000361818(uc021tsq.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP2K3 (see all 15):
    hsa-miR-3120-3p hsa-miR-1271 hsa-miR-486-3p hsa-miR-21 hsa-miR-4298 hsa-miR-590-5p hsa-miR-1302 hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmidMAP2K3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAP2K3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP2K3
    Clone
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    OriGene clones in human, mouse for MAP2K3 (see all 13)
    OriGene ORF clones in mouse, rat for MAP2K3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MAP2K3 (NM_145109)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP2K3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP2K3
    Sirion Biotech Customized lentivirus for stable overexpression of MAP2K3 
                         Customized lentivirus expression plasmids for stable overexpression of MAP2K3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAP2K3
    OriGene qSTAR qPCR primer pairs in human, mouse for MAP2K3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAP2K3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP2K3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP2K3

    Additional mRNA sequence: 

    AB451226.1 AB451349.1 AK093838.1 AK223490.1 AK315505.1 BC032478.1 CR536514.1 CR541793.1 
    D87116.1 GQ225578.1 L36719.1 U66839.1 

    15 DOTS entries:

    DT.446970  DT.100823564  DT.100037680  DT.100823555  DT.120936585  DT.120936615  DT.95155849  DT.100823557 
    DT.100808041  DT.100823561  DT.120936602  DT.120936626  DT.97837366  DT.451515  DT.95296285 

    24/342 AceView cDNA sequences (see all 342):

    BX340121 BQ879506 AI243926 BQ670365 AU076483 BQ948504 AW440947 R25570 
    BQ055837 BM908521 BM473776 BM824506 CD364438 BM458979 NM_002756 BQ438126 
    BQ065202 CB153446 AI380883 BI335777 CR541793 BQ064972 AI582129 CA309785 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K3 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c
    SP1:                                                  -                                                           -                                 
    SP2:        -     -     -                             -                                                           -                                 
    SP3:        -     -     -     -     -                 -                                                           -                                 
    SP4:        -     -           -     -                 -                                                                                             
    SP5:        -     -     -     -     -                                                                                                               


    ECgene alternative splicing isoforms for MAP2K3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP2K3 expression in normal human tissues (normalized intensities)      MAP2K3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTGGAGCT
    MAP2K3 Expression
    About this image


    MAP2K3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             neutrophils   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             bone marrow   
     
     Limb (Muscoskeletal System)
             limb/forelimb   
     
     Hair (Integumentary System)
             mouse/organ system/integumental system   

    See MAP2K3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP2K3

    SOURCE GeneReport for Unigene cluster: Hs.514012

    UniProtKB/Swiss-Prot: MP2K3_HUMAN, P46734
    Tissue specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other
    tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAP2K3 (see all 7): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Cancer PathwayFinder in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Cellular Senescence in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MAP2K3 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map2k31 , 5 mitogen-activated protein kinase kinase 31, 5 90.59(n)1
    96.54(a)1
      11 (37.95 cM)5
    263971  NM_008928.41  NP_032954.11 
     609320335 
    chicken
    (Gallus gallus)
    Aves MAP2K31 mitogen-activated protein kinase kinase 3 83.46(n)
    92.25(a)
      416496  NM_001012787.1  NP_001012805.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAP2K36
    mitogen-activated protein kinase kinase 3
    81(a)
    1 ↔ 1
    GL343385.1(868741-887722)
    fruit fly
    (Drosophila melanogaster)
    Insecta lic1 , 3 activation of MAPK protein kinase3
    licorne1
    61(a)3
    62.85(n)1
    61.46(a)1
      11D103
    322571  NM_057814.31  NP_477162.11 
    worm
    (Caenorhabditis elegans)
    Secernentea sek-13 SER/THR-protein kinase 51(a)
    (best of 4)
      X(7852049-7854578)   --


    ENSEMBL Gene Tree for MAP2K3 (if available)
    TreeFam Gene Tree for MAP2K3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP2K3 gene
    MAP2K52  MAP2K22  MAP2K62  MAP2K42  MAP2K72  MAP2K12  
    18/22 SIMAP similar genes for MAP2K3 using alignment to 9 protein entries:     MP2K3_HUMAN (see all proteins) (see all similar genes):
    MAP2K6    DKFZp686N0154    MAP2K4    MAP2K7    MAPK8    MAP2K5
    STK25    MARK4    STK11    RPS6KA3    NEK6    STK3
    NEK7    STK4    MAP2K1    MAP2K2    TNIK    PAK4

    MAP2K3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1499 SNPs in MAP2K3 are shown (see all 1499)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0142084
    Colon cancer4--see VAR_0142082 R W mis40--------
    VAR_0142094
    Colon cancer4--see VAR_0142092 L V mis40--------
    VAR_0408174
    ----see VAR_0408172 R T mis40--------
    rs1135414871,2
    C--20391142(+) TTTTTT/-CAGGA 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs712917801,2
    C--20401082(+) GTGAA-/G/GG  
            
    GGGGG
    2 -- int11NA 2
    rs559630161,2
    C,F--20401087(+) GGGGGG/AGCCAC 2 -- int14Minor allele frequency- A:0.50NA CSA 8
    rs58197351,2
    C--20401088(+) GGGGG-/G/GG  
            
    CCACA
    2 -- int10--------
    rs58197361,2
    C--20401352(+) TTTTTT/-CACCT 2 -- int1 trp31Minor allele frequency- -:0.50CSA 2
    rs725358581,2
    C--20409025(+) TGGTC-/CA/TC 
            
    AGTTT
    2 -- int10--------
    rs105520131,2
    C--20409026(+) GGTCTCA/-GTTTG 2 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for MAP2K3 (21187968 - 21218552 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for MAP2K3 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2484557CNV Deletion19546169
    nsv435679CNV Deletion17901297
    esv2715753CNV Deletion23290073
    nsv512480CNV Loss21212237
    nsv511592CNV Loss21212237
    nsv907886CNV Loss21882294
    nsv907889CNV Gain21882294
    nsv907885CNV Gain21882294
    esv2640649CNV Gain19546169
    nsv907888CNV Gain21882294


    Human Gene Mutation Database (HGMD): MAP2K3
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602315    OMIM disorders: --

    UniProtKB/Swiss-Prot: MP2K3_HUMAN, P46734
  • Note=Defects in MAP2K3 may be involved in colon cancer

  • 20/28 diseases for MAP2K3 (see all 28):    About MalaCards
    toxoplasmosis    cytomegalovirus infection    amyotrophic lateral sclerosis    lateral sclerosis
    oral squamous cell carcinoma    rheumatoid arthritis    influenza    arthritis
    ischemia    cervical cancer    chronic lymphocytic leukemia    glioblastoma
    hypoxia    colon cancer    squamous cell carcinoma    cervicitis
    parkinson's disease    prostatitis    neuroblastoma    pancreatic cancer


    MAP2K3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    7 Novoseek inferred disease relationships for MAP2K3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 17.6 3 10097111 (2), 10606930 (1)
    shock 11.7 1 20004242 (1)
    glioma 0 2 17406030 (2)
    osteoarthritis 0 1 14695331 (1)
    rheumatoid arthritis 0 1 15778394 (1)
    tumors 0 2 10097111 (2)
    carcinoma 0 1 12944900 (1)

    Genetic Association Database (GAD): MAP2K3
    Human Genome Epidemiology (HuGE) Navigator: MAP2K3 (2 documents)

    Export disorders for MAP2K3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP2K3 gene, integrated from 9 sources (see all 196):
    (articles sorted by number of sources associating them with MAP2K3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. (PubMed id 8622669)1, 2, 9 Raingeaud J.... Davis R.J. (1996)
    2. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. (PubMed id 7839144)1, 2, 9 Derijard B.... Davis R.J. (1995)
    3. Genetic variants within the MAP kinase signalling net work and anti-TNF treatment response in rheumatoid arthritis patients. (PubMed id 20805296)1, 4 Coulthard L.R....McDermott M.F. (2011)
    4. Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation. (PubMed id 16709866)1, 2 McLaughlin N.J....Silliman C.C. (2006)
    5. Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. (PubMed id 16728640)1, 2 Mukherjee S....Orth K. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha. (PubMed id 11980910)1, 2 Lim S....Friedman E. (2002)
    9. Mutation analyses of 268 candidate genes in human tumor cell lines. (PubMed id 11414763)1, 2 Teng D.-H.... Wong A.K.C. (2001)
    10. Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. (PubMed id 11279118)1, 2 Chen Z. and Cobb M.H. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5606 HGNC: 6843 AceView: MAP2K3 Ensembl:ENSG00000034152 euGenes: HUgn5606
    ECgene: MAP2K3 Kegg: 5606 H-InvDB: MAP2K3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP2K3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP2K3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAP2K3 gene:
    Search GeneIP for patents involving MAP2K3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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