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Aliases for MAP2K3 Gene

Aliases for MAP2K3 Gene

  • Mitogen-Activated Protein Kinase Kinase 3 2 3 5
  • MAP Kinase Kinase 3 2 3 4
  • MAPK/ERK Kinase 3 2 3 4
  • Stress-Activated Protein Kinase Kinase 2 3 4
  • SAPK Kinase 2 3 4
  • EC 2.7.12.2 4 63
  • MAPKK 3 3 4
  • SAPKK-2 3 4
  • PRKMK3 3 4
  • SAPKK2 3 4
  • MEK 3 3 4
  • MEK3 3 4
  • MKK3 3 4
  • Dual Specificity Mitogen Activated Protein Kinase Kinase 3 2
  • MAPKK3 3
  • SKK2 4

External Ids for MAP2K3 Gene

Previous HGNC Symbols for MAP2K3 Gene

  • PRKMK3

Previous GeneCards Identifiers for MAP2K3 Gene

  • GC17M021362
  • GC17P022837
  • GC17P021092
  • GC17P021350
  • GC17P021128
  • GC17P020390
  • GC17P021187
  • GC17P021835
  • GC17P021870

Summaries for MAP2K3 Gene

Entrez Gene Summary for MAP2K3 Gene

  • The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP2K3 Gene

MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Immune System. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP2K2.

UniProtKB/Swiss-Prot for MAP2K3 Gene

  • Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.

Gene Wiki entry for MAP2K3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP2K3 Gene

Genomics for MAP2K3 Gene

Regulatory Elements for MAP2K3 Gene

Promoters for MAP2K3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAP2K3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MAP2K3 gene promoter:

Genomic Location for MAP2K3 Gene

Chromosome:
17
Start:
21,284,656 bp from pter
End:
21,315,240 bp from pter
Size:
30,585 bases
Orientation:
Plus strand

Genomic View for MAP2K3 Gene

Genes around MAP2K3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP2K3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP2K3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP2K3 Gene

Proteins for MAP2K3 Gene

  • Protein details for MAP2K3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46734-MP2K3_HUMAN
    Recommended name:
    Dual specificity mitogen-activated protein kinase kinase 3
    Protein Accession:
    P46734
    Secondary Accessions:
    • B3KSK7
    • Q99441
    • Q9UE71
    • Q9UE72

    Protein attributes for MAP2K3 Gene

    Size:
    347 amino acids
    Molecular mass:
    39318 Da
    Quaternary structure:
    • Binds to DYRK1B/MIRK and increases its kinase activity. Part of a complex with MAP3K3, RAC1 and CCM2. Interacts with ARRB1. Interacts with Yersinia yopJ.

    Alternative splice isoforms for MAP2K3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP2K3 Gene

Proteomics data for MAP2K3 Gene at MOPED

Post-translational modifications for MAP2K3 Gene

  • Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity. Phosphorylated by TAOK2.
  • Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
  • Ubiquitination at Lys 243
  • Modification sites at PhosphoSitePlus

Domains & Families for MAP2K3 Gene

Graphical View of Domain Structure for InterPro Entry

P46734

UniProtKB/Swiss-Prot:

MP2K3_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
genes like me logo Genes that share domains with MAP2K3: view

Function for MAP2K3 Gene

Molecular function for MAP2K3 Gene

GENATLAS Biochemistry:
mitogen-activated protein kinase kinase 3,critical component of TNF-stimulated signaling pathway that causes increased expression of inflammatory cytokines
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by dual phosphorylation on Ser-218 and Thr-222.
UniProtKB/Swiss-Prot Function:
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.

Enzyme Numbers (IUBMB) for MAP2K3 Gene

Gene Ontology (GO) - Molecular Function for MAP2K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with MAP2K3: view
genes like me logo Genes that share phenotypes with MAP2K3: view

Animal Models for MAP2K3 Gene

MGI Knock Outs for MAP2K3:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP2K3 Gene

Localization for MAP2K3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP2K3 Gene COMPARTMENTS Subcellular localization image for MAP2K3 gene
Compartment Confidence
cytosol 5
nucleus 5
endoplasmic reticulum 2
extracellular 2
mitochondrion 2
cytoskeleton 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAP2K3 Gene

Pathways & Interactions for MAP2K3 Gene

SuperPathways for MAP2K3 Gene

Superpath Contained pathways
1 MyD88 cascade initiated on plasma membrane
2 IL-2 Pathway
3 4-1BB Pathway
4 Toll-Like receptor Signaling Pathways
5 CNTF Signaling
genes like me logo Genes that share pathways with MAP2K3: view

SIGNOR curated interactions for MAP2K3 Gene

Gene Ontology (GO) - Biological Process for MAP2K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with MAP2K3: view

Drugs & Compounds for MAP2K3 Gene

(20) Drugs for MAP2K3 Gene - From: Novoseek, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dabrafenib Approved Pharma Inhibition, inhibitor BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase 70
Trametinib Approved Pharma inhibitor, Biomarker MEK 1/2 inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors 111
Adenosine triphosphate Approved Nutra 0
AZD6244 Pharma Inhibition, inhibitor 0
BAY86-9766 Pharma Inhibition, inhibitor MEK inhibitor, MEK Inhibitors 0

(3) Additional Compounds for MAP2K3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with MAP2K3: view

Transcripts for MAP2K3 Gene

Unigene Clusters for MAP2K3 Gene

Mitogen-activated protein kinase kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c
SP1: - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: -
SP8:
SP9: -

Relevant External Links for MAP2K3 Gene

GeneLoc Exon Structure for
MAP2K3
ECgene alternative splicing isoforms for
MAP2K3

Expression for MAP2K3 Gene

mRNA expression in normal human tissues for MAP2K3 Gene

mRNA differential expression in normal tissues according to GTEx for MAP2K3 Gene

This gene is overexpressed in Whole Blood (x10.8).

Protein differential expression in normal tissues from HIPED for MAP2K3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.9) and Heart (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP2K3 Gene



SOURCE GeneReport for Unigene cluster for MAP2K3 Gene Hs.514012

mRNA Expression by UniProt/SwissProt for MAP2K3 Gene

P46734-MP2K3_HUMAN
Tissue specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
genes like me logo Genes that share expression patterns with MAP2K3: view

Protein tissue co-expression partners for MAP2K3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MAP2K3 Gene

Orthologs for MAP2K3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP2K3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAP2K3 35
  • 90.78 (n)
  • 96.54 (a)
MAP2K3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP2K3 35
  • 92.03 (n)
  • 99.14 (a)
MAP2K3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map2k3 35
  • 90.59 (n)
  • 96.54 (a)
Map2k3 16
Map2k3 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAP2K3 35
  • 99.62 (n)
  • 100 (a)
-- 36
  • 95 (a)
OneToMany
MAP2K3 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100911550 35
  • 89.91 (n)
  • 96.54 (a)
oppossum
(Monodelphis domestica)
Mammalia MAP2K3 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP2K3 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP2K3 35
  • 82.83 (n)
  • 91.16 (a)
MAP2K3 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP2K3 36
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta lic 37
  • 61 (a)
lic 35
  • 63.47 (n)
  • 62.58 (a)
lic 36
  • 59 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000310 35
  • 67.21 (n)
  • 64.14 (a)
worm
(Caenorhabditis elegans)
Secernentea F35C8.1 37
  • 33 (a)
jkk-1 37
  • 40 (a)
sek-1 37
  • 51 (a)
VZC374L.1 37
  • 45 (a)
sek-1 36
  • 50 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3213 36
  • 60 (a)
OneToMany
Species with no ortholog for MAP2K3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MAP2K3 Gene

ENSEMBL:
Gene Tree for MAP2K3 (if available)
TreeFam:
Gene Tree for MAP2K3 (if available)

Paralogs for MAP2K3 Gene

Paralogs for MAP2K3 Gene

genes like me logo Genes that share paralogs with MAP2K3: view

Variants for MAP2K3 Gene

Sequence variations from dbSNP and Humsavar for MAP2K3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_014208 Colon cancer
VAR_014209 Colon cancer
VAR_040817 -
rs33911218 - 21,298,879(+) ACAGA(A/C)CCCCC reference, missense
rs34105301 - 21,300,581(+) CCATC(C/T)CAGAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MAP2K3 Gene

Variant ID Type Subtype PubMed ID
nsv907885 CNV Gain 21882294
nsv907886 CNV Loss 21882294
nsv907887 CNV Gain 21882294
nsv907888 CNV Gain 21882294
nsv907889 CNV Gain 21882294
esv2640649 CNV Gain 19546169
nsv511592 CNV Loss 21212237
nsv435679 CNV Deletion 17901297
nsv512480 CNV Loss 21212237
esv2484557 CNV Deletion 19546169
esv2715753 CNV Deletion 23290073

Variation tolerance for MAP2K3 Gene

Residual Variation Intolerance Score: 98.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP2K3 Gene

HapMap Linkage Disequilibrium report
MAP2K3
Human Gene Mutation Database (HGMD)
MAP2K3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP2K3 Gene

Disorders for MAP2K3 Gene

UniProtKB/Swiss-Prot

MP2K3_HUMAN
  • Note=Defects in MAP2K3 may be involved in colon cancer.

Relevant External Links for MAP2K3

Genetic Association Database (GAD)
MAP2K3
Human Genome Epidemiology (HuGE) Navigator
MAP2K3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP2K3

No disorders were found for MAP2K3 Gene.

No data available for MalaCards and Genatlas for MAP2K3 Gene

Publications for MAP2K3 Gene

  1. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. (PMID: 8622669) Raingeaud J. … Davis R.J. (Mol. Cell. Biol. 1996) 3 4 23 67
  2. MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2. (PMID: 20067578) Hsu C.H. … Wolozin B. (J. Neurochem. 2010) 3 23
  3. DJ-1 modulates the p38 mitogen-activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1. (PMID: 20213747) Mo J.S. … Park H.S. (J. Cell. Biochem. 2010) 3 23
  4. MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival. (PMID: 17406030) Demuth T. … Berens M.E. (Mol. Cancer Ther. 2007) 3 23
  5. Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3. (PMID: 17438131) Prickett T.D. … Brautigan D.L. (Mol. Cell. Biol. 2007) 3 23

Products for MAP2K3 Gene

Sources for MAP2K3 Gene

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