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MAP2K3 Gene

protein-coding   GIFtS: 73
GCID: GC17P021187

Mitogen-Activated Protein Kinase Kinase 3


(Previous symbol: PRKMK3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase Kinase 31 2     MAPKK 32 3
PRKMK31 2 3 5     MEK 32 3
MAP Kinase Kinase 31 2 3     SAPK Kinase 22 3
MAPK/ERK Kinase 31 2 3     EC 2.7.12.23 8
MEK32 3 5     MAPKK32 5
Stress-Activated Protein Kinase Kinase 22 3     Dual Specificity Mitogen Activated Protein Kinase Kinase 31
MKK32 3     Dual Specificity Mitogen-Activated Protein Kinase Kinase 32
SAPKK-22 3     SKK23
SAPKK22 3     

External Ids:    HGNC: 68431   Entrez Gene: 56062   Ensembl: ENSG000000341527   OMIM: 6023155   UniProtKB: P467343   

Export aliases for MAP2K3 gene to outside databases

Previous GC identifers: GC17M021362 GC17P022837 GC17P021092 GC17P021350 GC17P021128 GC17P020390


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP2K3 Gene:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase
family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP
kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be
activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is
found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive
activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is
involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants
that encode distinct isoforms have been reported for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAP2K3 Gene:
MAP2K3 (mitogen-activated protein kinase kinase 3) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is MAP2K5.

UniProtKB/Swiss-Prot: MP2K3_HUMAN, P46734
Function: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the
concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38

Gene Wiki entry for MAP2K3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP2K3 gene promoter:
         AP-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP2K3 promoter sequence
   Search Chromatin IP Primers for MAP2K3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP2K3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17q11.2

MAP2K3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP2K3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P021187:  view genomic region     (about GC identifiers)

Start:
21,187,968 bp from pter      End:
21,218,552 bp from pter
Size:
30,585 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MP2K3_HUMAN, P46734 (See protein sequence)
Recommended Name: Dual specificity mitogen-activated protein kinase kinase 3  
Size: 347 amino acids; 39318 Da
Subunit: Binds to DYRK1B/MIRK and increases its kinase activity. Part of a complex with MAP3K3, RAC1 and CCM2.
Interacts with ARRB1. Interacts with Yersinia yopJ
Secondary accessions: B3KSK7 Q99441 Q9UE71 Q9UE72
Alternative splicing: 3 isoforms:  P46734-1   P46734-2   P46734-3   

Explore the universe of human proteins at neXtProt for MAP2K3: NX_P46734

Explore proteomics data for MAP2K3 at MOPED

Post-translational modifications: 

  • Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the
    kinase activity. Phosphorylated by TAOK21
  • Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK
    signaling pathway1
  • Ubiquitination2 at Lys183, Lys243
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAP2K3 (P46734) (see all 7)
     WICMELM  AILRFPY  FYGALFREGD  IMAVKRIRATVN 


    See MAP2K3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002747.2  NP_659731.1  

    ENSEMBL proteins: 
     ENSP00000378869   ENSP00000345083   ENSP00000431203   ENSP00000463202   ENSP00000463417  
     ENSP00000464043   ENSP00000434068   ENSP00000319139   ENSP00000462178   ENSP00000355081  
    Reactome Protein details: P46734

    MAP2K3 Human Recombinant Protein Products:

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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for MAP2K3
    OriGene MassSpec for MAP2K3
    OriGene Custom Protein Services for MAP2K3
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    Novus Biologicals MAP2K3 Proteins
    Novus Biologicals MAP2K3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MAP2K3
    Cloud-Clone Corp. Proteins for MAP2K3

     
    Search eBioscience for Proteins for MAP2K3 

     
    antibodies-online proteins for MAP2K3 (15 products) 

     
    antibodies-online peptides for MAP2K3

    MAP2K3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP2K3
    R&D Systems Antibodies for MAP2K3 (MKK3)
    Cell Signaling Technology (CST) Antibodies for MAP2K3  (MKK3)
    OriGene Antibodies for MAP2K3
    OriGene Custom Antibody Services for MAP2K3
    Novus Biologicals MAP2K3 Antibodies
    Abcam antibodies for MAP2K3 (P46734, P52564)
    Cloud-Clone Corp. Antibodies for MAP2K3
    ThermoFisher Antibody for MAP2K3
    antibodies-online antibodies for MAP2K3 (197 products) 

    MAP2K3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAP2K3
    R&D Systems ELISAs for MAP2K3 (MKK3)         (see all)
    GenScript Custom Assay Services for MAP2K3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAP2K3
    Cloud-Clone Corp. CLIAs for MAP2K3
    Search eBioscience for ELISAs for MAP2K3 
    antibodies-online kits for MAP2K3 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAP2K: Mitogen-activated protein kinase cascade / Kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase 3
    STE7 family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P46734

    ProtoNet protein and cluster: P46734

    UniProtKB/Swiss-Prot: MP2K3_HUMAN, P46734
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with MAP2K3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MP2K3_HUMAN, P46734
    Function: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the
    concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by dual phosphorylation on Ser-218 and Thr-222

         Genatlas biochemistry entry for MAP2K3:
    mitogen-activated protein kinase kinase 3,critical component of TNF-stimulated signaling pathway that causes
    increased expression of inflammatory cytokines

         Enzyme Number (IUBMB): EC 2.7.12.21 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004702receptor signaling protein serine/threonine kinase activity IBA--
    GO:0004708MAP kinase kinase activity IBA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI11980910
         
    Find genes that share ontologies with MAP2K3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for MAP2K3:
     Decreased influenza A/WSN/33 r  Decreased substrate adherent c  Decreased viability 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Map2k3):
     cellular  hematopoietic system  immune system  mortality/aging 

    Find genes that share phenotypes with MAP2K3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Map2k3tm1Flv for MAP2K3

       genOway: Develop your customized and physiologically relevant rodent model for MAP2K3

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAP2K3:
    hsa-mir-30a-5p (MIRT028553), hsa-mir-124-3p (MIRT022960), hsa-mir-214-3p (MIRT005426)

    Block miRNA regulation of human, mouse, rat MAP2K3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP2K3 (see all 15):
    hsa-miR-3120-3p hsa-miR-1271 hsa-miR-486-3p hsa-miR-21 hsa-miR-4298 hsa-miR-590-5p hsa-miR-1302 hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmidMAP2K3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAP2K3
    Predesigned siRNA for gene silencing in human, mouse, rat MAP2K3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAP2K3

    Clone
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    OriGene clones in human, mouse for MAP2K3 (see all 13)
    OriGene ORF clones in mouse, rat for MAP2K3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MAP2K3 (NM_145109)
    Sino Biological Human cDNA Clone for MAP2K3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP2K3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP2K3
    Addgene plasmids for MAP2K3 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MAP2K3
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAP2K3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2K3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    extracellular2
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IBA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with MAP2K3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP2K3 About   (see all 84)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    IL-1 Family Signaling Pathways0.44
    NOD-like Receptor Signaling Pathways0.58
    Mucin expression in CF via TLRs, EGFR signaling pathways0.42
    Inflammasome Activation Pathways0.51
    Immune response IL 1 signaling pathway0.42
    2Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    3MAPK targets/ Nuclear events mediated by MAP kinases
    MAP kinase activation in TLR cascade0.61
    activated TAK1 mediates p38 MAPK activation0.00
    MAP Kinase Signaling0.31
    4G protein signaling Ras family GTPases in kinase cascades scheme
    G protein signaling Ras family GTPases in kinase cascades scheme 0.44
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    MAPK Cascade0.44
    5Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    Fc epsilon RI signaling pathway0.41


    Find genes that share SuperPaths with MAP2K3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 R&D Systems Pathways for MAP2K3
        NOD-like Receptor Signaling Pathways
    Inflammasome Activation Pathways
    IL-1 Family Signaling Pathways
    Toll-Like receptor Signaling Pathways
    TGF-beta Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAP2K3 (see all 78)
        Toll-Like Receptors Pathway
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    PACAP Signaling
    Rho Family GTPases

    1 Cell Signaling Technology (CST) Pathway for MAP2K3
        MAP Kinase Signaling

    Selected GeneGo (Thomson Reuters) Pathways for MAP2K3 (see all 21)
        G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Transcription PPAR Pathway
    Immune response IL-12-induced IFN-gamma production
    Development TGF-beta receptor signaling
    Mucin expression in CF via TLRs, EGFR signaling pathways

    Selected BioSystems Pathways for MAP2K3 (see all 26)
        MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    Integrin-mediated cell adhesion
    Senescence and Autophagy
    EGFR1 Signaling Pathway


    2 Reactome Pathways for MAP2K3
        Oxidative Stress Induced Senescence
    activated TAK1 mediates p38 MAPK activation

    2 PharmGKB Pathways for MAP2K3
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    Selected Kegg Pathways  (Kegg details for MAP2K3) (see all 11):
        MAPK signaling pathway
    Rap1 signaling pathway
    Toll-like receptor signaling pathway
    Fc epsilon RI signaling pathway
    TNF signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP2K3 (see all 7): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Cancer PathwayFinder in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Cellular Senescence in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAP2K3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAP2K3 (P467341, 2, 3 ENSP000003450834) via UniProtKB, MINT, STRING, and/or I2D (see all 705)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL13P263732, 3, ENSP000003078894MINT-7945693 MINT-8259833 I2D: score=2 STRING: ENSP00000307889
    DYRK1BQ9Y4631, 3, ENSP000003127894EBI-602462,EBI-634187 I2D: score=2 STRING: ENSP00000312789
    DCTN1Q142032, 3, ENSP000003547914MINT-7945693 I2D: score=1 STRING: ENSP00000354791
    MAPK14Q165391, 2, 3, ENSP000002297944EBI-602462,EBI-73946 MINT-4300259 I2D: score=3 STRING: ENSP00000229794
    MAP3K5Q996831, 3, ENSP000003519084EBI-602462,EBI-476263 I2D: score=1 STRING: ENSP00000351908
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade ----
    GO:0000187activation of MAPK activity TAS--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--

    Find genes that share ontologies with MAP2K3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAP2K3 (MP2K3)

    2 HMDB Compounds for MAP2K3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    10 Novoseek inferred chemical compound relationships for MAP2K3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sb 203580 81.8 7 15797859 (2), 11546797 (1), 10586114 (1), 10960075 (1) (see all 6)
    anisomycin 73.7 2 11259586 (1), 20004242 (1)
    mannitol 38.2 3 10842172 (1), 17438131 (1), 11078444 (1)
    tyrosine 32.3 3 11304531 (1), 15797859 (1), 11062067 (1)
    arsenite 30.2 1 11259586 (1)
    okadaic acid 28.3 3 18299321 (2), 10960075 (1)
    serine 16.2 2 10606930 (2)
    nitric oxide 0 3 16097952 (1), 19567397 (1)
    glucose 0 3 11546797 (1), 11279172 (1)
    calcium 0 1 15180997 (1)



    Find genes that share compounds with MAP2K3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAP2K3 gene (3 alternative transcripts): 
    NM_002756.4  NM_145109.2  NM_145110.1  

    Unigene Cluster for MAP2K3:

    Mitogen-activated protein kinase kinase 3
    Hs.514012  [show with all ESTs]
    Unigene Representative Sequence: AK093838
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395491(uc002gyt.3 uc021tsr.1) ENST00000342679(uc002gys.3)
    ENST00000534743 ENST00000529517 ENST00000483928 ENST00000479129 ENST00000583508
    ENST00000496046 ENST00000526076 ENST00000316920 ENST00000477540 ENST00000527123
    ENST00000361818(uc021tsq.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MAP2K3 (see all 15):
    hsa-miR-3120-3p hsa-miR-1271 hsa-miR-486-3p hsa-miR-21 hsa-miR-4298 hsa-miR-590-5p hsa-miR-1302 hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmidMAP2K3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MAP2K3
    Predesigned siRNA for gene silencing in human, mouse, rat MAP2K3
    Clone
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    OriGene ORF clones in mouse, rat for MAP2K3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MAP2K3 (NM_145109)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP2K3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP2K3
    Addgene plasmids for MAP2K3 
    Primer
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    OriGene qPCR primer pairs and template standards for MAP2K3
    OriGene qSTAR qPCR primer pairs in human, mouse for MAP2K3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAP2K3
      QuantiTect SYBR Green Assays in human, mouse, rat MAP2K3
      QuantiFast Probe-based Assays in human, mouse, rat MAP2K3

    Additional mRNA sequence: 

    AB451226.1 AB451349.1 AK093838.1 AK223490.1 AK315505.1 BC032478.1 CR536514.1 CR541793.1 
    D87116.1 GQ225578.1 L36719.1 U66839.1 

    15 DOTS entries:

    DT.446970  DT.100823564  DT.100037680  DT.100823555  DT.120936585  DT.120936615  DT.95155849  DT.100823557 
    DT.100808041  DT.100823561  DT.120936602  DT.120936626  DT.97837366  DT.451515  DT.95296285 

    Selected AceView cDNA sequences (see all 342):

    AK093838 CA411669 BQ064972 BM472346 BM836095 BQ065100 AU100167 AW338745 
    BQ063809 BQ100903 BG284162 BQ438126 BU069084 BQ670365 BM674540 BM837623 
    CF126544 BQ055503 BQ883747 L36719 BQ054705 CA311142 BC032478 BM792126 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K3 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c
    SP1:                                                  -                                                           -                                 
    SP2:        -     -     -                             -                                                           -                                 
    SP3:        -     -     -     -     -                 -                                                           -                                 
    SP4:        -     -           -     -                 -                                                                                             
    SP5:        -     -     -     -     -                                                                                                               


    ECgene alternative splicing isoforms for MAP2K3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAP2K3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTGGAGCT
    MAP2K3 Expression
    About this image


    MAP2K3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    MAP2K3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP2K3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514012

    UniProtKB/Swiss-Prot: MP2K3_HUMAN, P46734
    Tissue specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other
    tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP2K3 (see all 7): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Cancer PathwayFinder in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Cellular Senescence in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for MAP2K3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map2k31 , 5 mitogen-activated protein kinase kinase 31, 5 90.59(n)1
    96.54(a)1
      11 (37.95 cM)5
    263971  NM_008928.41  NP_032954.11 
     609320335 
    chicken
    (Gallus gallus)
    Aves MAP2K31 mitogen-activated protein kinase kinase 3 82.83(n)
    91.16(a)
      416496  NM_001012787.2  NP_001012805.2 
    lizard
    (Anolis carolinensis)
    Reptilia MAP2K36
    mitogen-activated protein kinase kinase 3
    81(a)
    1 ↔ 1
    GL343385.1(868741-887722)
    fruit fly
    (Drosophila melanogaster)
    Insecta lic1 , 3 activation of MAPK protein kinase3
    licorne1
    61(a)3
    63.47(n)1
    62.58(a)1
      11D103
    322571  NM_057814.31  NP_477162.11 
    worm
    (Caenorhabditis elegans)
    Secernentea sek-13 SER/THR-protein kinase 51(a)
    (best of 4)
      X(7852049-7854578)   --


    ENSEMBL Gene Tree for MAP2K3 (if available)
    TreeFam Gene Tree for MAP2K3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP2K3 gene
    MAP2K52  MAP2K22  MAP2K62  MAP2K42  MAP2K72  MAP2K12  
    Selected SIMAP similar genes for MAP2K3 using alignment to 9 protein entries:     MP2K3_HUMAN (see all proteins) (see all similar genes):
    MAP2K6    DKFZp686N0154    MAP2K7    MAP2K4    MAPK8    MAP2K5
    STK25    MARK4    STK11    RPS6KA3    NEK6    STK3
    NEK7    STK4    MAP2K1    MAP2K2    TNIK    PAK4

    Find genes that share paralogs with MAP2K3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP2K3 (see all 1499)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0142084
    Colon cancer4--see VAR_0142082 R W mis40--------
    VAR_0142094
    Colon cancer4--see VAR_0142092 L V mis40--------
    rs1135414871,2
    C--20391142(+) TTTTTT/-CAGGA 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs712917801,2
    C--20401082(+) GTGAA-/G/GG  
            
    GGGGG
    2 -- int11NA 2
    rs559630161,2
    C,F--20401087(+) GGGGGG/AGCCAC 2 -- int14Minor allele frequency- A:0.50NA CSA 8
    rs58197351,2
    C--20401088(+) GGGGG-/G/GG  
            
    CCACA
    2 -- int10--------
    rs58197361,2
    C--20401352(+) TTTTTT/-CACCT 2 -- int1 trp31Minor allele frequency- -:0.50CSA 2
    rs725358581,2
    C--20409025(+) TGGTC-/CA/TC 
            
    AGTTT
    2 -- int10--------
    rs105520131,2
    C--20409026(+) GGTCTCA/-GTTTG 2 -- int11Minor allele frequency- -:0.50CSA 2
    rs124529291,2
    C,F,A,H--20411299(+) CAGATG/AGAATC 2 -- int13Minor allele frequency- A:0.40NA 10

    HapMap Linkage Disequilibrium report for MAP2K3 (21187968 - 21218552 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAP2K3 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2484557CNV Deletion19546169
    nsv435679CNV Deletion17901297
    esv2715753CNV Deletion23290073
    nsv512480CNV Loss21212237
    nsv511592CNV Loss21212237
    nsv907886CNV Loss21882294
    nsv907889CNV Gain21882294
    nsv907885CNV Gain21882294
    esv2640649CNV Gain19546169
    nsv907888CNV Gain21882294

    Human Gene Mutation Database (HGMD): MAP2K3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP2K3
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP2K3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602315    OMIM disorders: --

    UniProtKB/Swiss-Prot: MP2K3_HUMAN, P46734
  • Note=Defects in MAP2K3 may be involved in colon cancer


  • Find genes that share disorders with MAP2K3           About GenesLikeMe

    7 Novoseek inferred disease relationships for MAP2K3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 17.6 3 10097111 (2), 10606930 (1)
    shock 11.7 1 20004242 (1)
    glioma 0 2 17406030 (2)
    osteoarthritis 0 1 14695331 (1)
    rheumatoid arthritis 0 1 15778394 (1)
    tumors 0 2 10097111 (2)
    carcinoma 0 1 12944900 (1)

    Genetic Association Database (GAD): MAP2K3
    Human Genome Epidemiology (HuGE) Navigator: MAP2K3 (2 documents)

    Export disorders for MAP2K3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP2K3 gene, integrated from 10 sources (see all 198):
    (articles sorted by number of sources associating them with MAP2K3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. (PubMed id 8622669)1, 2, 9 Raingeaud J.... Davis R.J. (Mol. Cell. Biol. 1996)
    2. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. (PubMed id 7839144)1, 2, 9 Derijard B.... Davis R.J. (Science 1995)
    3. Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients. (PubMed id 20805296)1, 4 Coulthard L.R....McDermott M.F. (Ann. Rheum. Dis. 2011)
    4. Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation. (PubMed id 16709866)1, 2 McLaughlin N.J.... Silliman C.C. (J. Immunol. 2006)
    5. Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. (PubMed id 16728640)1, 2 Mukherjee S....Orth K. (Science 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha. (PubMed id 11980910)1, 2 Lim S.... Friedman E. (J. Biol. Chem. 2002)
    9. Mutation analyses of 268 candidate genes in human tumor cell lines. (PubMed id 11414763)1, 2 Teng D.-H.... Wong A.K.C. (Genomics 2001)
    10. Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. (PubMed id 11279118)1, 2 Chen Z. and Cobb M.H. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5606 HGNC: 6843 AceView: MAP2K3 Ensembl:ENSG00000034152 euGenes: HUgn5606
    ECgene: MAP2K3 Kegg: 5606 H-InvDB: MAP2K3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAP2K3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP2K3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MAP2K3 gene:
    Search GeneIP for patents involving MAP2K3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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