Aliases for MAP2K3 Gene
External Ids for MAP2K3 Gene
Previous HGNC Symbols for MAP2K3 Gene
Previous GeneCards Identifiers for MAP2K3 Gene
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAP2K3 Gene
MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3) is a Protein Coding gene. Diseases associated with MAP2K3 include Cerebral Cavernous Malformations-2. Among its related pathways are Trk receptor signaling mediated by the MAPK pathway and Development VEGF signaling via VEGFR2 - generic cascades. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP2K6.
UniProtKB/Swiss-Prot for MAP2K3 Gene
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.