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Aliases for MAP2K3 Gene

Aliases for MAP2K3 Gene

  • Mitogen-Activated Protein Kinase Kinase 3 2 3 5
  • MAP Kinase Kinase 3 2 3 4
  • MAPK/ERK Kinase 3 2 3 4
  • Stress-Activated Protein Kinase Kinase 2 3 4
  • SAPK Kinase 2 3 4
  • EC 4 61
  • MAPKK 3 3 4
  • SAPKK-2 3 4
  • PRKMK3 3 4
  • SAPKK2 3 4
  • MEK 3 3 4
  • MEK3 3 4
  • MKK3 3 4
  • Dual Specificity Mitogen-Activated Protein Kinase Kinase 3 3
  • Dual Specificity Mitogen Activated Protein Kinase Kinase 3 2
  • MAPKK3 3
  • SKK2 4

External Ids for MAP2K3 Gene

Previous HGNC Symbols for MAP2K3 Gene

  • PRKMK3

Previous GeneCards Identifiers for MAP2K3 Gene

  • GC17M021362
  • GC17P022837
  • GC17P021092
  • GC17P021350
  • GC17P021128
  • GC17P020390
  • GC17P021187
  • GC17P021835
  • GC17P021870
  • GC17P022695
  • GC17P023026
  • GC17P023313

Summaries for MAP2K3 Gene

Entrez Gene Summary for MAP2K3 Gene

  • The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP2K3 Gene

MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3) is a Protein Coding gene. Diseases associated with MAP2K3 include Cerebral Cavernous Malformations-2. Among its related pathways are Trk receptor signaling mediated by the MAPK pathway and Development VEGF signaling via VEGFR2 - generic cascades. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP2K6.

UniProtKB/Swiss-Prot for MAP2K3 Gene

  • Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.

Gene Wiki entry for MAP2K3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP2K3 Gene

Genomics for MAP2K3 Gene

Regulatory Elements for MAP2K3 Gene

Enhancers for MAP2K3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G021322 1.3 Ensembl ENCODE 10.8 +38.5 38545 1.2 HDGF ATF1 CREB3L1 ARNT ARID4B SIN3A DMAP1 GLI4 ZNF2 YY1 UPF3AP2 KCNJ12 MAP2K3 MEIS3P2 PIR55402 GC17M021294
GH17G021257 1.1 Ensembl ENCODE 12.5 -27.5 -27456 0.4 HDAC1 NFIB INSM2 FEZF1 ZNF366 ZSCAN5C FOS SMARCA5 SP3 ZNF362 MAP2K3 ENSG00000235530 TMEM11 DHRS7B NATD1 EIF1P5
GH17G021411 1.1 ENCODE dbSUPER 10.7 +126.5 126498 0.3 TBP SREBF2 BRCA1 RFX5 GLIS2 ELK1 RCOR1 ELK4 SMARCC1 USF2 MEIS3P2 MAP2K3 GC17M021385 GC17M021394
GH17G021419 1 ENCODE 10.9 +135.1 135060 1.3 HDGF CREB3L1 ARID4B SIN3A GLI4 ZNF2 YY1 ZNF121 ZNF143 NFYC MAP2K3 GC17P024169 PDLIM1P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAP2K3 on UCSC Golden Path with GeneCards custom track

Promoters for MAP2K3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Transcription factor binding sites by QIAGEN in the MAP2K3 gene promoter:

Genomic Location for MAP2K3 Gene

21,284,656 bp from pter
21,315,240 bp from pter
30,585 bases
Plus strand

Genomic View for MAP2K3 Gene

Genes around MAP2K3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP2K3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP2K3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP2K3 Gene

Proteins for MAP2K3 Gene

  • Protein details for MAP2K3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity mitogen-activated protein kinase kinase 3
    Protein Accession:
    Secondary Accessions:
    • B3KSK7
    • Q99441
    • Q9UE71
    • Q9UE72

    Protein attributes for MAP2K3 Gene

    347 amino acids
    Molecular mass:
    39318 Da
    Quaternary structure:
    • Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381). Binds to DYRK1B/MIRK and increases its kinase activity (PubMed:11980910). Part of a complex with MAP3K3, RAC1 and CCM2 (By similarity). Interacts with ARRB1 (PubMed:16709866). Interacts with Yersinia yopJ (PubMed:16728640).

    Alternative splice isoforms for MAP2K3 Gene


neXtProt entry for MAP2K3 Gene

Selected DME Specific Peptides for MAP2K3 Gene


Post-translational modifications for MAP2K3 Gene

  • Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity (PubMed:8622669). Phosphorylated by TAOK2 (PubMed:11279118).
  • Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
  • Ubiquitination at posLast=243243
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAP2K3 (MKK3)
  • Abcam antibodies for MAP2K3
  • Cloud-Clone Corp. Antibodies for MAP2K3

Domains & Families for MAP2K3 Gene

Protein Domains for MAP2K3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
genes like me logo Genes that share domains with MAP2K3: view

Function for MAP2K3 Gene

Molecular function for MAP2K3 Gene

GENATLAS Biochemistry:
mitogen-activated protein kinase kinase 3,critical component of TNF-stimulated signaling pathway that causes increased expression of inflammatory cytokines
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by dual phosphorylation on Ser-218 and Thr-222.
UniProtKB/Swiss-Prot Function:
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.

Enzyme Numbers (IUBMB) for MAP2K3 Gene

Gene Ontology (GO) - Molecular Function for MAP2K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity IBA --
GO:0004708 MAP kinase kinase activity IEA,TAS --
genes like me logo Genes that share ontologies with MAP2K3: view
genes like me logo Genes that share phenotypes with MAP2K3: view

Animal Models for MAP2K3 Gene

MGI Knock Outs for MAP2K3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP2K3 Gene

Localization for MAP2K3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP2K3 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
plasma membrane 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MAP2K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with MAP2K3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP2K3 Gene

Pathways & Interactions for MAP2K3 Gene

SuperPathways for MAP2K3 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 IL-2 Pathway
3 Toll-Like receptor Signaling Pathways
4 4-1BB Pathway
5 CNTF Signaling
genes like me logo Genes that share pathways with MAP2K3: view

Pathways by source for MAP2K3 Gene

SIGNOR curated interactions for MAP2K3 Gene

Gene Ontology (GO) - Biological Process for MAP2K3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0000187 activation of MAPK activity TAS --
GO:0006468 protein phosphorylation IEA --
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction TAS 7839144
genes like me logo Genes that share ontologies with MAP2K3: view

Drugs & Compounds for MAP2K3 Gene

(26) Drugs for MAP2K3 Gene - From: ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dabrafenib Approved Pharma Inhibition, inhibitor BRAF kinase inhibitor, Kinase Inhibitors, Mutant BRAF Kinase 84
Trametinib Approved Pharma inhibitor, Biomarker MEK 1/2 inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors 131
Adenosine triphosphate Approved Nutra 0
PD-0325901 Investigational Pharma inhibitor 0
AZD6244 (Selumetinib) Pharma MEK inhibitor 0

(2) Additional Compounds for MAP2K3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(5) ApexBio Compounds for MAP2K3 Gene

Compound Action Cas Number
AZD6244 (Selumetinib) MEK inhibitor 606143-52-6
PD0325901 MEK inhibitor 391210-10-9
PD184352 (CI-1040) Selective MEK inhibitor 212631-79-3
PD98059 MEK inhibitor,selective and reversible 167869-21-8
TAK-733 MEK allosteric site inhibitor 1035555-63-5
genes like me logo Genes that share compounds with MAP2K3: view

Drug Products

Transcripts for MAP2K3 Gene

Unigene Clusters for MAP2K3 Gene

Mitogen-activated protein kinase kinase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c
SP1: - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: -
SP9: -

Relevant External Links for MAP2K3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP2K3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP2K3 Gene

mRNA differential expression in normal tissues according to GTEx for MAP2K3 Gene

This gene is overexpressed in Whole Blood (x10.8).

Protein differential expression in normal tissues from HIPED for MAP2K3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.9) and Heart (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP2K3 Gene

Protein tissue co-expression partners for MAP2K3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAP2K3 Gene:


SOURCE GeneReport for Unigene cluster for MAP2K3 Gene:


mRNA Expression by UniProt/SwissProt for MAP2K3 Gene:

Tissue specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

Evidence on tissue expression from TISSUES for MAP2K3 Gene

  • Blood(4.6)
  • Muscle(4.6)
  • Nervous system(4.6)
  • Skin(3.3)
  • Lung(2.9)
  • Kidney(2.8)
  • Heart(2.4)
  • Liver(2.3)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with MAP2K3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP2K3 Gene

Orthologs for MAP2K3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP2K3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAP2K3 34 35
  • 99.62 (n)
-- 35
  • 95 (a)
(Monodelphis domestica)
Mammalia MAP2K3 35
  • 93 (a)
(Canis familiaris)
Mammalia MAP2K3 34 35
  • 92.03 (n)
(Ornithorhynchus anatinus)
Mammalia MAP2K3 35
  • 91 (a)
(Bos Taurus)
Mammalia MAP2K3 34 35
  • 90.78 (n)
(Mus musculus)
Mammalia Map2k3 34 16 35
  • 90.59 (n)
(Rattus norvegicus)
Mammalia Map2k3 34
  • 89.91 (n)
(Gallus gallus)
Aves MAP2K3 34 35
  • 82.83 (n)
(Anolis carolinensis)
Reptilia MAP2K3 35
  • 81 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000310 34
  • 67.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta lic 36 34 35
  • 63.47 (n)
(Caenorhabditis elegans)
Secernentea sek-1 36 35
  • 51 (a)
VZC374L.1 36
  • 45 (a)
jkk-1 36
  • 40 (a)
F35C8.1 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3213 35
  • 60 (a)
Species where no ortholog for MAP2K3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MAP2K3 Gene

Gene Tree for MAP2K3 (if available)
Gene Tree for MAP2K3 (if available)

Paralogs for MAP2K3 Gene

Paralogs for MAP2K3 Gene Pseudogenes for MAP2K3 Gene

genes like me logo Genes that share paralogs with MAP2K3: view

Variants for MAP2K3 Gene

Sequence variations from dbSNP and Humsavar for MAP2K3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_014208 Colon cancer
VAR_014209 Colon cancer
rs74575904 Uncertain significance 21,304,501(+) CTACT(G/T)GGTGG reference, missense
rs1000064651 -- 21,292,650(+) ATGTG(A/C)TAATT intron-variant
rs1000180896 -- 21,293,322(+) CTTCC(C/T)TCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP2K3 Gene

Variant ID Type Subtype PubMed ID
dgv1433n106 CNV duplication 24896259
esv2484557 CNV deletion 19546169
esv2640649 CNV gain 19546169
esv3389999 CNV duplication 20981092
nsv1059146 CNV gain 25217958
nsv1076442 CNV duplication 25765185
nsv1078306 OTHER inversion 25765185
nsv1116197 CNV deletion 24896259
nsv1123102 CNV deletion 24896259
nsv1127546 CNV deletion 24896259
nsv1134612 CNV deletion 24896259
nsv1134613 CNV deletion 24896259
nsv1138509 CNV deletion 24896259
nsv1150229 CNV duplication 26484159
nsv435679 CNV deletion 17901297
nsv511592 CNV loss 21212237
nsv512480 CNV loss 21212237
nsv953853 CNV duplication 24416366
nsv978395 CNV duplication 23825009

Variation tolerance for MAP2K3 Gene

Residual Variation Intolerance Score: 98.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP2K3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP2K3 Gene

Disorders for MAP2K3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAP2K3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cerebral cavernous malformations-2
  • cerebral cavernous malformation 2
- elite association - COSMIC cancer census association via MalaCards


  • Note=Defects in MAP2K3 may be involved in colon cancer.

Relevant External Links for MAP2K3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MAP2K3: view

No data available for Genatlas for MAP2K3 Gene

Publications for MAP2K3 Gene

  1. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. (PMID: 8622669) Raingeaud J. … Davis R.J. (Mol. Cell. Biol. 1996) 3 4 22 64
  2. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. (PMID: 7839144) Derijard B. … Davis R.J. (Science 1995) 3 4 22 64
  3. Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients. (PMID: 20805296) Coulthard L.R. … McDermott M.F. (Ann. Rheum. Dis. 2011) 3 46 64
  4. DJ-1 modulates the p38 mitogen-activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1. (PMID: 20213747) Mo J.S. … Park H.S. (J. Cell. Biochem. 2010) 3 22 64
  5. MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2. (PMID: 20067578) Hsu C.H. … Wolozin B. (J. Neurochem. 2010) 3 22 64

Products for MAP2K3 Gene

Sources for MAP2K3 Gene