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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP2K3 Gene

protein-coding   GIFtS: 70
GCID: GC17P021187

mitogen-activated protein kinase kinase 3


(Previous symbol: PRKMK3)
 Explore 32 diseases affiliated with
MAP2K3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAP2K3    

Aliases
for MAP2K3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase Kinase 31 2     MAP Kinase Kinase 32 3
MEK31 2 3 5     MAPK/ERK Kinase 32 3
PRKMK31 2 3 5     MAPKK 32 3
MKK31 2 3     MEK 32 3
MAPKK31 2 5     SAPK Kinase 22 3
Stress-Activated Protein Kinase Kinase 22 3     EC 2.7.12.23 8
SAPKK-22 3     Dual Specificity Mitogen-Activated Protein Kinase Kinase 32
SAPKK22 3     SKK23

External Ids:    HGNC: 68431   Entrez Gene: 56062   Ensembl: ENSG000000341527   OMIM: 6023155   UniProtKB: P467343   

Export aliases for MAP2K3 gene to outside databases

Previous GC identifers: GC17M021362 GC17P022837 GC17P021092 GC17P021350 GC17P021128 GC17P020390


Summaries
for MAP2K3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAP2K3:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family.
This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling
cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is
necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation
of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic
transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina
pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been
reported for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MP2K3_HUMAN, P46734
Function: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the
concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38

Gene Wiki entry for MAP2K3


Genomic Views
for MAP2K3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP2K3 gene promoter:
         AP-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAP2K3 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP2K3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP2K3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17q11.2

MAP2K3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP2K3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P021187:  view genomic region     (about GC identifiers)

Start:
 21,187,968 bp from pter      End:
 21,218,552 bp from pter
Size:
 30,585 bases      Orientation:
 plus strand

Proteins
for MAP2K3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MP2K3_HUMAN, P46734 (See protein sequence)
Recommended Name: Dual specificity mitogen-activated protein kinase kinase 3  
Size: 347 amino acids; 39318 Da
Subunit: Binds to DYRK1B/MIRK and increases its kinase activity. Part of a complex with MAP3K3, RAC1 and CCM2.
Interacts with ARRB1. Interacts with Yersinia yopJ
Secondary accessions: B3KSK7 Q99441 Q9UE71 Q9UE72
Alternative splicing: 3 isoforms:  P46734-1   P46734-2   P46734-3   

Explore the universe of human proteins at neXtProt for MAP2K3: NX_P46734

Post-translational modifications:

  • Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase
    • activity. Phosphorylated by TAOK21
  • Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK
    • signaling pathway1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P46734

    • 4/7 DME Specific Peptides for MAP2K3 (P46734) (see all 7)
     WICMELM  AILRFPY  FYGALFREGD  IMAVKRIRATVN 

    MAP2K3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_002747.2  NP_659731.1  

    ENSEMBL proteins: 
     ENSP00000378869   ENSP00000345083   ENSP00000431203   ENSP00000463202   ENSP00000463417  
     ENSP00000464043   ENSP00000434068   ENSP00000319139   ENSP00000462178   ENSP00000355081  
    Reactome Protein details: P46734
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant MAP2K3 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): MAP2K3
    OriGene Protein Over-expression Lysate: MAP2K3
    OriGene Custom Protein Services for MAP2K3 
    GenScript Custom Purified and Recombinant Proteins Services for MAP2K3
    Novus Biologicals MAP2K3 Proteins
    Novus Biologicals MAP2K3 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for MAP2K3
    Uscn Proteins for MAP2K3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--


    MAP2K3 for ontologies           About GeneDecksing



    MAP2K3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP2K3
    R&D Systems Antibodies for MAP2K3 (MKK3)
    Cell Signaling Technology (CST) Antibodies for MAP2K3  (MKK3)
    OriGene Antibodies (see all 32): MAP2K3
    OriGene Custom Antibody Services for MAP2K3 
    GenScript Custom Superior Antibodies Services for MAP2K3
    Novus Biologicals MAP2K3 Antibodies
    Abcam antibodies for MAP2K3 
    Uscn Antibodies for MAP2K3
    ThermoFisher Antibody for MAP2K3

    Assay Products for MAP2K3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
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    R&D Systems ELISAs for MAP2K3 (MKK3)         (see all)
    GenScript Custom Assay Services for MAP2K3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MAP2K3

    Protein Domains /
    Families
    for MAP2K3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAP2K3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P46734

    ProtoNet protein and cluster: P46734

    UniProtKB/Swiss-Prot: MP2K3_HUMAN, P46734
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for MAP2K3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MP2K3_HUMAN, P46734
    Function: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the
    concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by dual phosphorylation on Ser-218 and Thr-222

         Genatlas biochemistry entry for MAP2K3:
    mitogen-activated protein kinase kinase 3,critical component of TNF-stimulated signaling pathway that causes increased
    expression of inflammatory cytokines

    Enzyme Number (IUBMB): EC 2.7.12.21 2

    miRNA
    Products:            		miRTarBase miRNAs that target MAP2K3:
    hsa-mir-214 (MIRT005426)

    OriGene 3'-UTR Clone (see all 2): MAP2K3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP2K3
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP2K3 (see all 15):
    hsa-miR-3120-3p hsa-miR-1271 hsa-miR-486-3p hsa-miR-21 hsa-miR-4298 hsa-miR-590-5p hsa-miR-1302 hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmid: MAP2K3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP2K3 (see all 7)
    OriGene shRNA RFP: MAP2K3
    OriGene siRNA: MAP2K3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP2K3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAP2K3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP2K3 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP2K3 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MAP2K3 (NM_145109)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP2K3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP2K3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MAP2K3
    Search LifeMap BioReagents cell lines for MAP2K3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2K3

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004708MAP kinase kinase activity IEA--
    GO:0004713protein tyrosine kinase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--


    MAP2K3 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for MAP2K3:
     Decreased influenza A/WSN/33 r  Decreased substrate adherent c  Decreased viability 

    Animal Models:
         Mouse knock-out Map2k3tm1Flv for MAP2K3
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Map2k3):
     cellular  immune system  mortality/aging 

    MAP2K3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAP2K3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/83 super-pathways (see all 83) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TRAF6 Mediated Induction of proinflammatory cytokines
    8/19 pathways (see all 19)
    		TRAF6 Mediated Induction of proinflammatory cytokines1.00
    		Toll Like Receptor TLR1:TLR2 Cascade0.78
    		MAP kinase activation in TLR cascade0.88
    		Toll Like Receptor 2 (TLR2) Cascade0.78
    		Toll Like Receptor 5 (TLR5) Cascade0.86
    		MyD88:Mal cascade initiated on plasma membrane0.78
    		Toll Like Receptor 10 (TLR10) Cascade0.86
    		TRIF-mediated TLR3/TLR4 signaling 0.73
    2ErbB4 Pathway
    8/12 pathways (see all 12)
    		ErbB4 Pathway1.00
    		LPS Stimulated MAPK Signaling0.36
    		ErbB Family Pathway0.59
    		VEGF Signaling Pathway0.35
    		Prolactin Signaling0.54
    		TREM1 Pathway0.32
    		ErbB2-ErbB3 Heterodimers0.47
    		HMGB1 Pathway0.32
    3G-protein signaling_Ras family GTPases in kinase cascades (scheme)
    		G-protein signaling Ras family GTPases in kinase cascades (scheme)1.00
    		Immune response Oncostatin M signaling via MAPK in human cells0.39
    		G-protein signaling_Ras family GTPases in kinase cascades (scheme)1.00
    		Immune response_Role of integrins in NK cells cytotoxicity0.28
    		MAPK Cascade0.44
    		Immune response Role of integrins in NK cells cytotoxicity0.28
    		Immune response_Oncostatin M signaling via MAPK in human cells0.39
    44-1BB Pathway
    		4-1BB Pathway1.00
    		CMV and MAPK Pathways0.38
    		CD40 Signaling0.54
    		PKR Pathway0.36
    		CD27 Pathway0.48
    		SUMO Pathway0.30
    5Development_CNTF receptor signaling
    		Development_Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    		Translation Regulation activity of EIF4F0.32
    		Development Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    		Cell adhesion Plasmin signaling0.07
    		Translation _Regulation of EIF4F activity0.32
    		Cell adhesion_Plasmin signaling0.07

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/18 EMD Millipore Pathways for MAP2K3 (see all 18)
        Development A1 receptor signaling
    Development TGF-beta receptor signaling
    G-protein signaling Ras family GTPases in kinase cascades (scheme)
    Immune response IL-1 signaling pathway
    Transcription PPAR Pathway

    3 R&D Systems Pathways for MAP2K3
        Inflammasome Activation Pathways
    Toll-Like receptor Signaling Pathways
    TGF-beta Signaling Pathways

    5/78 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP2K3 (see all 78)
        Toll-Like Receptors Pathway
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    PACAP Signaling
    Rho Family GTPases

    1 Cell Signaling Technology (CST) Pathway for MAP2K3
        MAP Kinase Signaling

    5/21 GeneGo (Thomson Reuters) Pathways for MAP2K3 (see all 21)
        G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Transcription PPAR Pathway
    Immune response IL-12-induced IFN-gamma production
    Development TGF-beta receptor signaling
    Mucin expression in CF via TLRs, EGFR signaling pathways

    5/23 BioSystems Pathways for MAP2K3 (see all 23) 
        Integrin-mediated cell adhesion
    Senescence and Autophagy
    EGFR1 Signaling Pathway
    Signaling Pathways in Glioblastoma
    Focal Adhesion

    5/22        Reactome Pathways for MAP2K3 (see all 22)
        Toll Like Receptor 2 (TLR2) Cascade
    Toll Like Receptor TLR6:TLR2 Cascade
    Toll-Like Receptors Cascades
    TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 7/8 (TLR7/8) Cascade

    2 PharmGKB Pathways for MAP2K3
        Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    VEGF Signaling Pathway

    5/7         Kegg Pathways  (Kegg details for MAP2K3) (see all 7):
        MAPK signaling pathway
    Toll-like receptor signaling pathway
    Fc epsilon RI signaling pathway
    GnRH signaling pathway
    Amyotrophic lateral sclerosis (ALS)


    MAP2K3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP2K3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/624 Interacting proteins for MAP2K3 (P467341, 2, 3 ENSP000003450834) via UniProtKB, MINT, STRING, and/or I2D (see all 624)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL13P263732, 3, ENSP000003078894MINT-7945693 MINT-8259833 I2D: score=2 STRING: ENSP00000307889
    DYRK1BQ9Y4631, 3, ENSP000003127894EBI-602462,EBI-634187 I2D: score=2 STRING: ENSP00000312789
    DCTN1Q142032, 3, ENSP000003547914MINT-7945693 I2D: score=1 STRING: ENSP00000354791
    MAPK14Q165392, 3, ENSP000002297944MINT-4300259 I2D: score=3 STRING: ENSP00000229794
    MAP3K5Q996831, 3, ENSP000003519084EBI-602462,EBI-476263 I2D: score=1 STRING: ENSP00000351908
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade ----
    GO:0000187activation of MAPK activity TAS--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--


    MAP2K3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAP2K3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP2K3 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAP2K3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP2K3

    2 HMDB Compounds for MAP2K3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    10 Novoseek chemical compound relationships for MAP2K3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sb 203580 81.8 7 15797859 (2), 11546797 (1), 10586114 (1), 10960075 (1) (see all 6)
    anisomycin 73.7 2 11259586 (1), 20004242 (1)
    mannitol 38.2 3 10842172 (1), 17438131 (1), 11078444 (1)
    tyrosine 32.3 3 11304531 (1), 15797859 (1), 11062067 (1)
    arsenite 30.2 1 11259586 (1)
    okadaic acid 28.3 3 18299321 (2), 10960075 (1)
    serine 16.2 2 10606930 (2)
    nitric oxide 0 3 16097952 (1), 19567397 (1)
    glucose 0 3 11546797 (1), 11279172 (1)
    calcium 0 1 15180997 (1)

    Search CenterWatch for drugs/clinical trials and news about MAP2K3 / MP2K3 

    Transcripts
    for MAP2K3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAP2K3 gene (3 alternative transcripts): 
    NM_002756.4  NM_145109.2  NM_145110.1  

    Unigene Cluster for MAP2K3:

    Mitogen-activated protein kinase kinase 3
    Hs.514012  [show with all ESTs]
    Unigene Representative Sequence: AK093838
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395491(uc002gyt.3 uc021tsr.1) ENST00000342679(uc002gys.3)
    ENST00000534743 ENST00000529517 ENST00000483928 ENST00000479129 ENST00000583508
    ENST00000496046 ENST00000526076 ENST00000316920 ENST00000477540 ENST00000527123
    ENST00000361818(uc021tsq.1)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): MAP2K3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP2K3
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP2K3 (see all 15):
    hsa-miR-3120-3p hsa-miR-1271 hsa-miR-486-3p hsa-miR-21 hsa-miR-4298 hsa-miR-590-5p hsa-miR-1302 hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmid: MAP2K3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP2K3 (see all 7)
    OriGene shRNA RFP: MAP2K3
    OriGene siRNA: MAP2K3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP2K3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP2K3 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP2K3 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MAP2K3 (NM_145109)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP2K3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP2K3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP2K3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAP2K3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP2K3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP2K3

    Additional cDNA sequence: 

    AB451226.1 AB451349.1 AK093838.1 AK223490.1 AK315505.1 BC032478.1 CR536514.1 CR541793.1 
    D87116.1 GQ225578.1 L36719.1 U66839.1 

    15 DOTS entries:

    DT.446970  DT.100823564  DT.100037680  DT.100823555  DT.120936585  DT.120936615  DT.95155849  DT.100823557 
    DT.100808041  DT.100823561  DT.120936602  DT.120936626  DT.97837366  DT.451515  DT.95296285 

    24/342 AceView cDNA sequences (see all 342):

    BQ673899 BM836867 CA311142 BG284162 T23566 BM453771 BQ059828 BQ438126 
    BM353147 BM824815 BQ948504 BM792126 D20875 BQ057699 BM472346 AW338745 
    BQ641970 BM908521 CA411669 CR541793 CR536514 BE886789 BI335777 BX358456 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K3 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c
    SP1:                                                  -                                                           -                                 
    SP2:        -     -     -                             -                                                           -                                 
    SP3:        -     -     -     -     -                 -                                                           -                                 
    SP4:        -     -           -     -                 -                                                                                             
    SP5:        -     -     -     -     -                                                                                                               


    ECgene alternative splicing isoforms for MAP2K3

    Expression
    for MAP2K3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP2K3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTTGGAGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MAP2K3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP2K3

    SOURCE GeneReport for Unigene cluster: Hs.514012

    UniProtKB/Swiss-Prot: MP2K3_HUMAN, P46734
    Tissue specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAP2K3 (see all 7): 
              Antiviral Response in human mouse rat
              Toll-Like Receptor Signaling Pathway in human mouse rat
              Cancer PathwayFinder in human mouse rat
              NFKB Signaling Pathway in human mouse rat
              Cellular Senescence in human mouse rat

    Primer
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    Orthologs
    for MAP2K3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAP2K3 gene from 7/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAP2K31 mitogen-activated protein kinase kinase 3 83.46(n)
    92.25(a)    		   416496  NM_001012787.1  NP_001012805.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MAP2K36
    		 --
    		 82(a)
    		 1 ↔ 1
    		 GL343385.1(876329-886765)
    zebrafish
    (Danio rerio)    		 Actinopterygii map2k66
    		 mitogen-activated protein kinase kinase 6
    		 74(a)
    		 1 ↔ 1
    		 12(37501579-37551068)
    fruit fly
    (Drosophila melanogaster)    		 Insecta lic1 , 3 activation of MAPK protein kinase3
    licorne1    		 61(a)3
    62.85(n)1
    61.46(a)1    		   11D103
    322571  NM_057814.31  NP_477162.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea sek-13 SER/THR-protein kinase 51(a)
    (best of 4)    		   X(7852049-7854578)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATMKK66
    ATMKK106
    (see all 10)    		 MAP kinase kinase 10
    (see all 10)    		 29(a)
    27(a)
    (see all 10)    		 possible ortholog
    possible ortholog
    (see all 10)    		 5(22904689-22906661)
    1(11655156-11656073)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 11)    		 STE_MEK_ste7_MAP2K.2 - STE kinases include homolog...
    OsMKK1 - putative MAPKK based on amino acid sequen...
    (see all 11)    		 29(a)
    28(a)
    (see all 11)    		 possible ortholog
    possible ortholog
    (see all 11)    		 1(17903729-17909128)
    6(2497848-2501902)


    ENSEMBL Gene Tree for MAP2K3 (if available)
    TreeFam Gene Tree for MAP2K3 (if available) 

    Paralogs
    for MAP2K3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP2K3 gene
    MAP2K52  MAP2K22  MAP2K62  MAP2K42  MAP2K72  MAP2K12  
    18/24 SIMAP similar genes for MAP2K3 using alignment to 9 protein entries:     MP2K3_HUMAN (see all proteins) (see all similar genes):
    MAP2K6    DKFZp686N0154    MAP2K4    MAP2K7    MAPK8    MAP2K5
    STK25    MARK4    STK11    RPS6KA3    NEK6    STK3
    NEK7    STK4    MAP2K1    TNIK    PAK4    DKFZp686L02273

    MAP2K3 for paralogs           About GeneDecksing



    Genomic Variants
    for MAP2K3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1312 NCBI SNPs in MAP2K3 are shown (see all 1312)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs739825861,2
    		C,--20387941(+) CAGCAG/ACATAA 1 -- us2k13Minor allele frequency- A:0.10WA NA 240
    rs739844071,2
    		C,--20387942(+) AGCAGC/TATAAG 1 -- us2k13Minor allele frequency- T:0.10WA NA 240
    rs801587041,2
    		F,--20387973(+) ACCATG/CATGAG 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs770320221,2
    		F,--20388027(+) GAGAGG/AGAACC 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs787251011,2
    		F,--20388425(+) TGAAAC/TGCTTT 1 -- us2k12Minor allele frequency- T:0.07WA NA 238
    rs794787051,2
    		F,--20388696(+) TTTACA/TCCTGG 1 -- us2k12Minor allele frequency- T:0.03WA NA 238
    rs789279911,2
    		F,--20388764(+) CCTCAC/TGTGAG 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs733096341,2
    		C,--20389060(+) AAATGC/TACCGC 1 -- us2k12Minor allele frequency- T:0.07WA NA 122
    rs557675331,2
    		--20390030(+) GCCGCC/TGCCGC 1 -- ut510--------
    rs413092761,2
    		F,--20390322(+) GGCAGC/TGGCGT 1 -- int11Minor allele frequency- T:0.04NA 120

    HapMap Linkage Disequilibrium report for MAP2K3 (21187968 - 21218552 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for MAP2K3
         3 CNVs: 23191 102424 102425
    Human Gene Mutation Database (HGMD): MAP2K3

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for MAP2K3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAP2K3 for disorders           About GeneDecksing

    OMIM gene information: 602315    OMIM disorders: --

    UniProtKB/Swiss-Prot: MP2K3_HUMAN, P46734
  • Note=Defects in MAP2K3 may be involved in colon cancer

    • 20/32 diseases for MAP2K3 (see all 32):    About MalaCards
    amyotrophic lateral sclerosis (als)    amyotrophic lateral sclerosis    lateral sclerosis    oral squamous cell carcinoma
    squamous cell carcinoma    cytomegalovirus infection    rheumatoid arthritis    chronic lymphocytic leukemia
    lymphocytic leukemia    osteoarthritis    toxoplasmosis    arthritis
    ovarian carcinoma    cervical cancer    carcinoma    cervicitis
    colon cancer    influenza    pancreatic cancer    prostate carcinoma

    7 Novoseek disease relationships for MAP2K3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 17.6 3 10097111 (2), 10606930 (1)
    shock 11.7 1 20004242 (1)
    glioma 0 2 17406030 (2)
    osteoarthritis 0 1 14695331 (1)
    rheumatoid arthritis 0 1 15778394 (1)
    tumors 0 2 10097111 (2)
    carcinoma 0 1 12944900 (1)

    Human Genome Epidemiology (HuGE) Navigator: MAP2K3 (2 documents)

    Export disorders for MAP2K3 gene to outside databases

    Publications
    for MAP2K3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP2K3 gene, integrated from 9 sources (see all 190):
    (articles sorted by number of sources associating them with MAP2K3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. (PubMed id 8622669)1, 2, 9 Raingeaud J.... Davis R.J. (1996)
    2. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. (PubMed id 7839144)1, 2, 9 Derijard B.... Davis R.J. (1995)
    3. Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. (PubMed id 16728640)1, 2 Mukherjee S....Orth K. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Mirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alpha. (PubMed id 11980910)1, 2 Lim S....Friedman E. (2002)
    7. Mutation analyses of 268 candidate genes in human tumor cell lines. (PubMed id 11414763)1, 2 Teng D.-H.... Wong A.K.C. (2001)
    8. Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. (PubMed id 11279118)1, 2 Chen Z. and Cobb M.H. (2001)
    9. Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5. (PubMed id 9465908)1, 3 Rampoldi L....Danieli G.A. (1997)
    10. Purification and identification of a major activator for p38 from osmotically shocked cells: activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2. (PubMed id 8900184)1, 2 Moriguchi T.... Nishida E. (1996)

    External Searches for MAP2K3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAP2K3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5606 HGNC: 6843 AceView: MAP2K3 Ensembl:ENSG00000034152 euGenes: HUgn5606
    ECgene: MAP2K3 Kegg: 5606 H-InvDB: MAP2K3

    Other Databases showing MAP2K3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAP2K3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP2K3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP2K3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MAP2K3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAP2K3 gene:
    Search GeneIP for patents involving MAP2K3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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