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MAP2K2 Gene

protein-coding   GIFtS: 77
GCID: GC19M004090

Mitogen-Activated Protein Kinase Kinase 2


(Previous symbol: PRKMK2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase Kinase 21 2     EC 2.7.12.23 8
PRKMK21 2 3 5     CFC42 5
MEK22 3 5     MAPKK22
MKK22 3 5     Dual Specificity Mitogen-Activated Protein Kinase Kinase 22
ERK Activator Kinase 22 3     Mitogen-Activated Protein Kinase Kinase 2, P452
MAP Kinase Kinase 22 3     MAPKK 23
MAPK/ERK Kinase 22 3     MEK 23

External Ids:    HGNC: 68421   Entrez Gene: 56052   Ensembl: ENSG000001269347   OMIM: 6012635   UniProtKB: P365073   

Export aliases for MAP2K2 gene to outside databases

Previous GC identifers: GC19M004183 GC19M004030 GC19M004041 GC19M003854


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP2K2 Gene:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase
family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It
phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on
the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous
syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial
features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to
be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been
identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAP2K2 Gene:
MAP2K2 (mitogen-activated protein kinase kinase 2) is a protein-coding gene. Diseases associated with MAP2K2 include cardiofaciocutaneous syndrome 4, and map2k2-related cardiofaciocutaneous syndrome. GO annotations related to this gene include PDZ domain binding and protein serine/threonine kinase activity. An important paralog of this gene is MAP2K3.

UniProtKB/Swiss-Prot: MP2K2_HUMAN, P36507
Function: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr
sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity)

Gene Wiki entry for MAP2K2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP2K2 gene promoter:
         CREB   PPAR-gamma1   deltaCREB   STAT3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP2K2 promoter sequence
   Search Chromatin IP Primers for MAP2K2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP2K2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

MAP2K2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP2K2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M004090:  view genomic region     (about GC identifiers)

Start:
4,090,319 bp from pter      End:
4,124,126 bp from pter
Size:
33,808 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MP2K2_HUMAN, P36507 (See protein sequence)
Recommended Name: Dual specificity mitogen-activated protein kinase kinase 2  
Size: 400 amino acids; 44424 Da
Subunit: Interacts with MORG1 (By similarity). Interacts with SGK1
2 PDB 3D structures from and Proteopedia for MAP2K2:
1S9I (3D)        4H3Q (3D)    

Explore the universe of human proteins at neXtProt for MAP2K2: NX_P36507

Explore proteomics data for MAP2K2 at MOPED

Post-translational modifications: 

  • MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or
    MEKK1). Phosphorylated by MAP2K1/MEK1 (By similarity)1
  • Acetylation of Ser-222 and Ser-226 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the
    MAPK signaling pathway1
  • Ubiquitination2 at Lys88, Lys108, Lys196, Lys209
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAP2K2 (P36507) (see all 16)
     CNSPYIV  ELELDEQQ  VDFAGWLC  LQKKLEEL 


    See MAP2K2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_109587.1  
    ENSEMBL proteins: 
     ENSP00000262948   ENSP00000471763   ENSP00000378336  
    Reactome Protein details: P36507

    MAP2K2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MAP2K2 Protein
    R&D Systems Recombinant & Natural Proteins for MAP2K2 (MEK2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MAP2K2
    OriGene Protein Over-expression Lysate for MAP2K2
    OriGene MassSpec for MAP2K2
    OriGene Custom Protein Services for MAP2K2
    GenScript Custom Purified and Recombinant Proteins Services for MAP2K2
    Novus Biologicals MAP2K2 Proteins
    Novus Biologicals MAP2K2 Lysates
    Sino Biological Recombinant Protein for MAP2K2
    Sino Biological Cell Lysate for MAP2K2
    ProSpec Recombinant Protein for MAP2K2
    Cloud-Clone Corp. Proteins for MAP2K2

    MAP2K2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP2K2
    R&D Systems Antibodies for MAP2K2 (MEK2)
    Cell Signaling Technology (CST) Antibodies for MAP2K2  (MEK2)
    OriGene Antibodies for MAP2K2
    OriGene Custom Antibody Services for MAP2K2
    Novus Biologicals MAP2K2 Antibodies
    Abcam antibodies for MAP2K2 (P36507, Q02750)
    Cloud-Clone Corp. Antibodies for MAP2K2
    ThermoFisher Antibody for MAP2K2
    LSBio Antibodies in human, mouse, rat for MAP2K2

    MAP2K2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAP2K2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAP2K2
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAP2K2 (MEK2)
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAP2K2
    Cloud-Clone Corp. CLIAs for MAP2K2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAP2K: Mitogen-activated protein kinase cascade / Kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase 2
    STE7 family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P36507

    ProtoNet protein and cluster: P36507

    UniProtKB/Swiss-Prot: MP2K2_HUMAN, P36507
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain


    MAP2K2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MP2K2_HUMAN, P36507
    Function: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr
    sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.12.21 2

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004708MAP kinase kinase activity IDA8388392
    GO:0004712protein serine/threonine/tyrosine kinase activity TAS19565474
    GO:0004713protein tyrosine kinase activity IEA--
         
    MAP2K2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MAP2K2:
     Decreased substrate adherent c  Increased cell death HMECs cel  Upregulation of Wnt/beta-caten 

         13 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Map2k2):
     cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     hearing/vestibular/ear  homeostasis/metabolism  integument  mortality/aging  normal 
     skeleton  tumorigenesis  vision/eye 

    MAP2K2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Map2k2tm1Chrn for MAP2K2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAP2K2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAP2K2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP2K2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP2K2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAP2K2:
    hsa-let-7b-5p (MIRT032459), hsa-mir-7-5p (MIRT025900)

    Block miRNA regulation of human, mouse, rat MAP2K2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MAP2K2
    SwitchGear 3'UTR luciferase reporter plasmidMAP2K2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAP2K2
    Predesigned siRNA for gene silencing in human, mouse, rat MAP2K2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAP2K2

    Clone
    Products:
         
    OriGene clones in human, mouse for MAP2K2 (see all 8)
    OriGene ORF clones in mouse, rat for MAP2K2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAP2K2 (NM_030662)
    Sino Biological Human cDNA Clone for MAP2K2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP2K2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP2K2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAP2K2
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAP2K2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2K2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    endoplasmic reticulum5
    endosome5
    extracellular5
    golgi apparatus5
    mitochondrion5
    nucleus5
    peroxisome5
    plasma membrane5

    Gene Ontology (GO): Selected cellular component terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS8388392
    GO:0005634nucleus TAS19565474
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion TAS19565474
    GO:0005769early endosome TAS19565474

    MAP2K2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP2K2 About   (see all 139)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    VEGF - VEGF R2 Signaling Pathways0.35
    Fc epsilon RI signaling pathway0.41
    Fc-epsilon receptor I signaling in mast cells0.34
    VEGF signaling pathway0.39
    2IL-9 Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    IL-7 Signaling Pathways0.90
    IL-9 Signaling Pathway0.42
    IL-21 Signaling Pathways0.90
    Immune response IL 9 signaling pathway0.42
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    IL-7 Signaling Pathway0.40
    3Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Development CNTF receptor signaling0.43
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Cell adhesion PLAU signaling0.35
    Transcription Receptor mediated HIF regulation0.51
    Insulin signaling pathway0.32
    Translation Regulation activity of EIF20.47
    ErbB2/ErbB3 signaling events0.31
    4Development HGF signaling pathway
    Development HGF signaling pathway0.45
    Neurotrophin signaling pathway0.36
    Development Neurotrophin family signaling0.45
    Signaling of Hepatocyte Growth Factor Receptor0.35
    Development EGFR signaling via small GTPases0.44
    Apoptosis and survival Anti apoptotic action of membrane bound ESR10.35
    Development PDGF signaling via MAPK cascades0.41
    5Prolactin Signaling Pathway
    Development Prolactin receptor signaling0.39
    Leptin signaling pathway0.35
    Prolactin Signaling Pathway0.39
    Prolactin signaling pathway0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for MAP2K2 (see all 11)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAP2K2 (see all 97)
        Molecular Mechanisms of Cancer
    eIF2 Pathway
    CDK5 Pathway
    PACAP Signaling
    Rho Family GTPases

    1 Cell Signaling Technology (CST) Pathway for MAP2K2
        MAP Kinase Signaling

    5 Tocris Bioscience Pathways for MAP2K2
        Insulin Pathway
    Apoptosis Pathway
    Toll-like Receptor Pathway
    VEGF Pathway
    MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for MAP2K2 (see all 71)
        Development A2A receptor signaling
    Development CNTF receptor signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Immune response IL-9 signaling pathway

    Selected BioSystems Pathways for MAP2K2 (see all 43)
        MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    Integrin-mediated cell adhesion
    Hypothetical Network for Drug Addiction

    4 Sino Biological Pathways for MAP2K2
        EGFR Signaling Pathway
    Non-Canonical Wnt Pathway
    VEGF Signaling
    TGF-beta Signaling Pathway

    5 Reactome Pathways for MAP2K2
        Signaling by FGFR
    MEK activation
    Signal transduction by L1
    RAF phosphorylates MEK
    ERK2 activation

    3 PharmGKB Pathways for MAP2K2
        Sorafenib Pharmacodynamics
    VEGF Signaling Pathway
    Vemurafenib Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for MAP2K2) (see all 42):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    HIF-1 signaling pathway


    MAP2K2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP2K2: 
              VEGF Signaling in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Gap Junctions in human mouse rat
              Osmotic Stress in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAP2K2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAP2K2 (P365071, 2, 3 ENSP000002629484) via UniProtKB, MINT, STRING, and/or I2D (see all 772)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG1Q129591, 2, 3, ENSP000003457314EBI-1056930,EBI-357481 MINT-8183078 MINT-8183016 MINT-8183060 MINT-8183037 MINT-8183089 MINT-8183138 MINT-8183069 MINT-8183103 MINT-8182991 MINT-8183118 I2D: score=1 STRING: ENSP00000345731
    ARAFP103981, 3, ENSP000003662444EBI-1056930,EBI-365961 I2D: score=5 STRING: ENSP00000366244
    COPS5Q929052, 3, ENSP000003505124MINT-7945693 I2D: score=3 STRING: ENSP00000350512
    MAPK1P284823, ENSP000002158324I2D: score=5 STRING: ENSP00000215832
    MAPK3P273613, ENSP000002630254I2D: score=5 STRING: ENSP00000263025
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 33):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade TAS--
    GO:0000186activation of MAPKK activity TAS--
    GO:0000187activation of MAPK activity TAS19565474
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--

    MAP2K2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MAP2K2
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAP2K2 (MP2K2)

    2 HMDB Compounds for MAP2K2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    10 Novoseek inferred chemical compound relationships for MAP2K2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pd 98,059 52.9 3 12801927 (1), 15381709 (1), 10395291 (1)
    threonine 46 2 19206169 (1), 15543157 (1)
    phosphatidylinositol 33.9 2 18202115 (1), 8702863 (1)
    fmlp 30.1 2 8969228 (1), 9552001 (1)
    serine 29.1 4 17116858 (2), 19206169 (1), 10828601 (1)
    tyrosine 21.8 4 17380122 (1), 15543157 (1), 18940803 (1), 7538132 (1)
    wortmannin 12.9 1 8702863 (1)
    phosphoinositide 6.22 1 15147509 (1)
    cycloheximide 0.567 1 11977986 (1)
    nitric oxide 0 2 15147509 (1), 15728793 (1)



    MAP2K2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAP2K2 gene: 
    NM_030662.3  

    Unigene Cluster for MAP2K2:

    Mitogen-activated protein kinase kinase 2
    Hs.465627  [show with all ESTs]
    Unigene Representative Sequence: BM809871
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262948(uc002lzk.3) ENST00000600584 ENST00000601786 ENST00000597263
    ENST00000599021 ENST00000595715 ENST00000593364 ENST00000602167 ENST00000597008
    ENST00000599345 ENST00000394867
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MAP2K2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MAP2K2
    SwitchGear 3'UTR luciferase reporter plasmidMAP2K2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MAP2K2
    Predesigned siRNA for gene silencing in human, mouse, rat MAP2K2
    Clone
    Products:
         
    OriGene clones in human, mouse for MAP2K2 (see all 8)
    OriGene ORF clones in mouse, rat for MAP2K2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAP2K2 (NM_030662)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP2K2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP2K2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAP2K2
    OriGene qSTAR qPCR primer pairs in human, mouse for MAP2K2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAP2K2
      QuantiTect SYBR Green Assays in human, mouse, rat MAP2K2
      QuantiFast Probe-based Assays in human, mouse, rat MAP2K2

    Additional mRNA sequence: 

    BC000471.2 BC018645.2 BX538081.1 L11285.1 

    24 DOTS entries:

    DT.100813934  DT.452895  DT.100813943  DT.95122783  DT.100050970  DT.121463368  DT.95112902  DT.99955121 
    DT.101985152  DT.99941010  DT.121463385  DT.100728450  DT.100813940  DT.121463365  DT.86840886  DT.100813944 
    DT.95261745  DT.121463338  DT.121463361  DT.40122725  DT.75197914  DT.121463382  DT.75176168  DT.91676095 

    Selected AceView cDNA sequences (see all 543):

    CA420531 BE906836 AI424330 CR615045 BE645547 BE646428 BG574706 BQ020412 
    BG753679 CA443724 BE395964 AK129586 BQ954951 BQ066367 BE378426 BQ685740 
    AI080739 AI080740 BM738798 BU845593 BU630910 BQ688179 BM981756 AI092151 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14
    SP1:                    -     -     -                 -                       -                       -     -               
    SP2:                                                  -                       -                       -     -               
    SP3:                                                  -                                                                     
    SP4:                                                                                                                        
    SP5:                                                  -                                                                     


    ECgene alternative splicing isoforms for MAP2K2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAP2K2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGAACGGG
    MAP2K2 Expression
    About this image


    MAP2K2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Eye (Sensory Organs)
             Lens
    MAP2K2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP2K2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465627
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP2K2: 
              VEGF Signaling in human mouse rat
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat
              Gap Junctions in human mouse rat
              Osmotic Stress in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2K2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAP2K2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map2k21 , 5 mitogen-activated protein kinase kinase 21, 5 87.25(n)1
    94.25(a)1
      10 (39.72 cM)5
    263961  NM_023138.41  NP_075627.21 
     811059155 
    chicken
    (Gallus gallus)
    Aves MAP2K21 mitogen-activated protein kinase kinase 2 82.08(n)
    93.97(a)
      396349  NM_205388.1  NP_990719.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAP2K26
    mitogen-activated protein kinase kinase 2
    85(a)
    1 ↔ 1
    AAWZ02038541(642-7948)
    zebrafish
    (Danio rerio)
    Actinopterygii map2k2a1 mitogen-activated protein kinase kinase 2a 76.26(n)
    86.11(a)
      563181  NM_001037391.2  NP_001032468.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dsor13 signal transduction receptor signaling
    protein more
    63(a)   1 8D10   --
    worm
    (Caenorhabditis elegans)
    Secernentea mek-23 protein kinase 53(a)   I(3006030-3013446)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PBS2(YJL128C)4
    STE71
    MAP kinase kinase of the HOG signaling pathway; activated more4
    STE71
    50.06(n)1
    45.09(a)1
      10(180103-178097)4
    8513961  NP_010122.11  8533134 
     NP_012407.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MKK61 MKK6 50.16(n)
    42.67(a)
      835759  NM_125041.2  NP_200469.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g05101001 Os01g0510100 51.09(n)
    44.16(a)
      4324023  NM_001049699.1  NP_001043164.1 


    ENSEMBL Gene Tree for MAP2K2 (if available)
    TreeFam Gene Tree for MAP2K2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP2K2 gene
    MAP2K32  MAP2K52  MAP2K62  MAP2K42  MAP2K72  MAP2K12  
    15 SIMAP similar genes for MAP2K2 using alignment to 4 protein entries:     MP2K2_HUMAN (see all proteins):
    DKFZp686L02273    MAP2K1    NEK6    MARK4    MAP2K5    RPS6KA2
    MAP2K3    STK11    MAP2K6    STK4    STK3    MAP2K4
    MAP2K7    NUAK1    CDK4

    MAP2K2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MAP2K2
    PGOHUM00000250969


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP2K2 (see all 978)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0697814
    Cardiofaciocutaneous syndrome 4 (CFC4)4--see VAR_0697812 F V mis40--------
    VAR_0697824
    Cardiofaciocutaneous syndrome 4 (CFC4)4--see VAR_0697822 P Q mis40--------
    VAR_0350954
    Cardiofaciocutaneous syndrome 4 (CFC4)4--see VAR_0350952 F C mis40--------
    VAR_0697834
    Cardiofaciocutaneous syndrome 4 (CFC4)4--see VAR_0697832 Y H mis40--------
    rs613742771,2
    C,F--3853629(+) AGAGAT/CGGTGG 1 -- ds50011Minor allele frequency- C:0.24WA 118
    rs2399961,2
    C,F,A,H--3853713(-) GTGCGT/CTCCGG 1 -- ds500118Minor allele frequency- C:0.29NS EA NA CSA 1432
    rs1845632121,2
    --3853717(+) AGCGCA/GCTGGC 1 -- ds50010--------
    rs3508861,2
    C,F,A,H--3853846(-) CTCTCA/GCCAAA 1 -- ds500119Minor allele frequency- G:0.47NS EA NA CSA WA 2048
    rs1170471931,2
    C,F--3853887(+) TTCATC/ACCTTG 1 -- ds50011Minor allele frequency- A:0.02NA 120
    rs1898825751,2
    --3853904(+) AGGGAA/GAGGCG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MAP2K2 (4090319 - 4124126 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAP2K2 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717979CNV Deletion23290073
    esv1448615CNV Insertion17803354
    nsv2393CNV Insertion18451855
    nsv833716CNV Loss17160897
    dgv3667n71CNV Loss21882294
    dgv3665n71CNV Loss21882294
    nsv910816CNV Loss21882294
    nsv470115CNV Loss18288195
    nsv910783CNV Loss21882294
    dgv3673n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): MAP2K2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP2K2
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP2K2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601263   
    OMIM disorders: 615280  
    UniProtKB/Swiss-Prot: MP2K2_HUMAN, P36507
  • Cardiofaciocutaneous syndrome 4 (CFC4) [MIM:615280]: A form of cardiofaciocutaneous syndrome, a multiple
    congenital anomaly disorder characterized by a distinctive facial appearance, heart defects and mental
    retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some
    affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin
    lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They
    include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral
    fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • Selected diseases for MAP2K2 (see all 64):    
    About MalaCards
    cardiofaciocutaneous syndrome 4    map2k2-related cardiofaciocutaneous syndrome    cardiofaciocutaneous syndrome    costello syndrome
    pulmonic stenosis    pulmonary valve stenosis    leopard syndrome    noonan syndrome
    polyploidy    drug addiction    prion disease    embryonal rhabdomyosarcoma
    lipoma    short stature    was-related disorders    barrett's esophagus
    hemangioma    tuberous sclerosis    pancreatic cancer    chronic myeloid leukemia

    2 diseases from the University of Copenhagen DISEASES database for MAP2K2:
    Costello syndrome     Noonan syndrome

    MAP2K2 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for MAP2K2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cfc syndrome 95.9 5 20052757 (1), 17211612 (1), 17661820 (1), 19376813 (1) (see all 5)
    noonan syndrome 85.8 2 19156172 (1), 17603483 (1)
    heart defects congenital 55 1 19376813 (1)
    anthrax 48.1 1 11977986 (1)
    macrocephaly 40.8 1 17211612 (1)
    pancreatic cancer 40.8 18 20514469 (5), 14654942 (4), 15547692 (3), 16110828 (2) (see all 5)
    short stature 34.7 1 17211612 (1)
    cancer 21.2 6 15547692 (2), 15010817 (1), 10216485 (1), 16110828 (1)
    tumors 17.2 4 19014680 (2), 14654942 (1), 18533112 (1)
    colorectal cancer 1.72 3 19014680 (3)

    GeneTests: MAP2K2
    GeneReviews: MAP2K2
    Genetic Association Database (GAD): MAP2K2
    Human Genome Epidemiology (HuGE) Navigator: MAP2K2 (6 documents)

    Export disorders for MAP2K2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP2K2 gene, integrated from 10 sources (see all 268):
    (articles sorted by number of sources associating them with MAP2K2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. (PubMed id 8388392)1, 2, 3, 9 Zheng C.-F. and Guan K.-L. (J. Biol. Chem. 1993)
    2. Spectrum of MEK1 and MEK2 gene mutations in cardio-facio-cutaneous syndrome and genotype-phenotype correlations. (PubMed id 19156172)1, 4, 9 Dentici M.L....Dallapiccola B. (Eur. J. Hum. Genet. 2009)
    3. Molecular and functional analysis of a novel MEK2 mutation in cardio-facio-cutaneous syndrome: transmission through four generations. (PubMed id 20358587)1, 2, 9 Rauen K.A....Lacassie Y. (Am. J. Med. Genet. A 2010)
    4. Investigation of gene dosage imbalances in patients with Noonan syndrome using multiplex ligation-dependent probe amplification analysis. (PubMed id 20302979)1, 4, 9 NystrAPm A.M....Bondeson M.L. (Eur J Med Genet 2010)
    5. Mutation and phenotypic spectrum in patients with cardio-facio- cutaneous and Costello syndrome. (PubMed id 18042262)1, 2, 9 Schulz A.L.... Zenker M. (Clin. Genet. 2008)
    6. Germline mutations in genes within the MAPK pathway cause cardio- facio-cutaneous syndrome. (PubMed id 16439621)1, 2, 9 Rodriguez-Viciana P.... Rauen K.A. (Science 2006)
    7. Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum. (PubMed id 19206169)1, 4, 9 Sarkozy A.... Tartaglia M. (Hum. Mutat. 2009)
    8. Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration. (PubMed id 19447520)1, 2 Won M....Hur G.M. (J. Hepatol. 2009)
    9. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5605 HGNC: 6842 AceView: MAP2K2 Ensembl:ENSG00000126934 euGenes: HUgn5605
    ECgene: MAP2K2 Kegg: 5605 H-InvDB: MAP2K2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAP2K2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP2K2 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=MAP2K2[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAP2K2 gene:
    Search GeneIP for patents involving MAP2K2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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