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Aliases for MAP2K1 Gene

Aliases for MAP2K1 Gene

  • Mitogen-Activated Protein Kinase Kinase 1 2 3 5
  • ERK Activator Kinase 1 3 4
  • MAPK/ERK Kinase 1 3 4
  • EC 2.7.12.2 4 61
  • MAPKK 1 3 4
  • PRKMK1 3 4
  • MEK 1 3 4
  • MEK1 3 4
  • MKK1 3 4
  • Protein Kinase, Mitogen-Activated, Kinase 1 (MAP Kinase Kinase 1) 3
  • Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 3
  • MAP Kinase Kinase 1 4
  • MAPKK1 3
  • CFC3 3

External Ids for MAP2K1 Gene

Previous HGNC Symbols for MAP2K1 Gene

  • PRKMK1

Previous GeneCards Identifiers for MAP2K1 Gene

  • GC15U990039
  • GC15P059778
  • GC15P064258
  • GC15P064395
  • GC15P064356
  • GC15P064466
  • GC15P066679
  • GC15P043515

Summaries for MAP2K1 Gene

Entrez Gene Summary for MAP2K1 Gene

  • The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]

CIViC summary for MAP2K1 Gene

  • MAP2K1 is a dual-specificity kinase known for it's involvement in the ERK pathway by activation of ERK1 and ERK2. MAP2K1 activating mutations have been observed in a number of cancers including ovarian, melanoma and lung. These activating mutations are generally found in the N-terminal negative regulatory region or the ATP-binding region of the N-terminal lobe. Inhibitors of MEK genes have been shown to inhibit tumor growth in these cases.

GeneCards Summary for MAP2K1 Gene

MAP2K1 (Mitogen-Activated Protein Kinase Kinase 1) is a Protein Coding gene. Diseases associated with MAP2K1 include Cardiofaciocutaneous Syndrome 3 and Cardiofaciocutaneous Syndrome. Among its related pathways are Trk receptor signaling mediated by the MAPK pathway and Development VEGF signaling via VEGFR2 - generic cascades. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAP2K2.

UniProtKB/Swiss-Prot for MAP2K1 Gene

  • Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.

Gene Wiki entry for MAP2K1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP2K1 Gene

Genomics for MAP2K1 Gene

Regulatory Elements for MAP2K1 Gene

Enhancers for MAP2K1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G066410 1.4 Ensembl ENCODE dbSUPER 12.5 +24.6 24574 1.6 WRNIP1 SIN3A ZNF48 ZNF2 ZNF335 GLIS2 ZNF391 EGR2 ZNF263 YY2 TIPIN SNAPC5 ENSG00000260773 MAP2K1 LOC646358 SLC24A1 SNORD18C ZWILCH SNORD16 SNORD18A
GH15G066415 1.1 FANTOM5 dbSUPER 12.4 +28.5 28487 0.2 HDGF CTCF FEZF1 RAD21 ZNF335 HIC1 GLIS2 ZNF366 ZBTB48 POLR2A MAP2K1 SNAPC5 SNORD16 SNORD18A ZWILCH RPL4 ATP5J2P6 GC15M066420
GH15G066369 1.7 FANTOM5 Ensembl ENCODE 8 -16.7 -16657 1.8 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B FEZF1 ZNF2 YY1 ZNF766 JUNB MAP2K1 LOC105370868 TIPIN RPL9P25 ENSG00000223271
GH15G066416 1.1 Ensembl ENCODE dbSUPER 11.9 +30.9 30918 1.9 PKNOX1 MTA2 BHLHE40 ZMYM3 NR2F2 ARID3A HDAC2 POLR2A ADNP KDM1A TIPIN SNAPC5 DIS3L MAP2K1 SNORD16 SNORD18A ZWILCH RPL4 ENSG00000261351 ATP5J2P6
GH15G066616 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.7 +233.3 233251 6.9 HDGF ATF1 FOXA2 CREB3L1 ARNT ARID4B ZNF2 YY1 ZNF766 ZNF143 MAP2K1 SMAD3 SMAD6 LINC01169 GC15P068446
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAP2K1 on UCSC Golden Path with GeneCards custom track

Promoters for MAP2K1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000078166 483 2601 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D SSRP1

Genomic Location for MAP2K1 Gene

Chromosome:
15
Start:
66,386,817 bp from pter
End:
66,492,312 bp from pter
Size:
105,496 bases
Orientation:
Plus strand

Genomic View for MAP2K1 Gene

Genes around MAP2K1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP2K1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP2K1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP2K1 Gene

Proteins for MAP2K1 Gene

  • Protein details for MAP2K1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02750-MP2K1_HUMAN
    Recommended name:
    Dual specificity mitogen-activated protein kinase kinase 1
    Protein Accession:
    Q02750

    Protein attributes for MAP2K1 Gene

    Size:
    393 amino acids
    Molecular mass:
    43439 Da
    Quaternary structure:
    • Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3/ERK1 and RGS14. Forms a heterodimer with MAP2K2/MEK2. Forms heterodimers with KSR2 which further dimerize to form tetramers. Interacts with ARBB2, LAMTOR3, MAPK1/ERK2, MORG1 and RAF1 (By similarity). Interacts with PPARG and with isoform 1 of VRK2 (PubMed:20679487, PubMed:17101779). Interacts with Yersinia yopJ (PubMed:16728640). Interacts with SGK1 (PubMed:19447520). Interacts with BIRC6/bruce (PubMed:18329369). Interacts with KSR1 (PubMed:10409742).

    Three dimensional structures from OCA and Proteopedia for MAP2K1 Gene

    Alternative splice isoforms for MAP2K1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP2K1 Gene

Selected DME Specific Peptides for MAP2K1 Gene

Q02750:
  • MARKLIHLE
  • KNPAERADLK
  • ILGKVSIAV
  • VDFAGWLC
  • HAFIKRS
  • LQKKLEEL
  • FYSDGEISICMEHMDGGSLDQVLK
  • KELELMFGC
  • CNSPYIV
  • LNQPSTPT
  • PEQILGKV
  • KVGELKDDDFE
  • GEIKLCDFGVSG
  • SELGAGNGGVVFKVSHKP
  • PIPPPDAKELE
  • ELELDEQQ
  • EFQDFVNKCL
  • MAIFELLDYIVNEPP
  • RLEAFLTQK
  • GRYPIPPPD
  • LIDSMANSFVGTRSYM

Post-translational modifications for MAP2K1 Gene

  • Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
  • Phosphorylation at Ser-218 and Ser-222 by MAP kinase kinase kinases (RAF or MEKK1) positively regulates kinase activity. Also phosphorylated at Thr-292 by MAPK1/ERK2 and at Ser-298 by PAK. MAPK1/ERK2 phosphorylation of Thr-292 occurs in response to cellular adhesion and leads to inhibition of Ser-298 phosphorylation by PAK.
  • Ubiquitination at Lys353
  • Modification sites at PhosphoSitePlus

Other Protein References for MAP2K1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAP2K1 (MEK1)

Assay Products

  • Cloud-Clone Corp. Assay Kits for MAP2K1

Domains & Families for MAP2K1 Gene

Protein Domains for MAP2K1 Gene

Graphical View of Domain Structure for InterPro Entry

Q02750

UniProtKB/Swiss-Prot:

MP2K1_HUMAN :
  • The proline-rich region localized between residues 270 and 307 is important for binding to RAF1 and activation of MAP2K1/MEK1.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Domain:
  • The proline-rich region localized between residues 270 and 307 is important for binding to RAF1 and activation of MAP2K1/MEK1.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
genes like me logo Genes that share domains with MAP2K1: view

Function for MAP2K1 Gene

Molecular function for MAP2K1 Gene

GENATLAS Biochemistry:
mitogen-activated protein kinase kinase 1,nucleocytoplasmic shuttling protein,involved in signal transduction
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Ras proteins such as HRAS mediate the activation of RAF proteins such as RAF1 or BRAF which in turn activate extracellular signal-regulated kinases (ERK) through MAPK (mitogen-activated protein kinases) and ERK kinases MAP2K1/MEK1 and MAP2K2/MEK2. Activation occurs through phosphorylation of Ser-218 and Ser-222. MAP2K1/MEK1 is also the target of negative feed-back regulation by its substrate kinases, such as MAPK1/ERK2. These phosphorylate MAP2K1/MEK1 on Thr-292, thereby facilitating dephosphorylation of the activating residues Ser-218 and Ser-222. Inhibited by serine/threonine phosphatase 2A (By similarity). Many inhibitors have been identified including pyrrole derivatives, TAK-733 (one of a series of 8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione derivatives), CH4987655 and RDEA119/BAY 869766.
UniProtKB/Swiss-Prot Function:
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.

Enzyme Numbers (IUBMB) for MAP2K1 Gene

Gene Ontology (GO) - Molecular Function for MAP2K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA,TAS 10570282
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004702 signal transducer, downstream of receptor, with serine/threonine kinase activity IBA --
GO:0004708 MAP kinase kinase activity IDA 8388392
genes like me logo Genes that share ontologies with MAP2K1: view
genes like me logo Genes that share phenotypes with MAP2K1: view

Human Phenotype Ontology for MAP2K1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MAP2K1 Gene

MGI Knock Outs for MAP2K1:

Animal Model Products

  • Taconic Biosciences Mouse Models for MAP2K1

CRISPR Products

miRNA for MAP2K1 Gene

miRTarBase miRNAs that target MAP2K1

Inhibitory RNA Products

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for MAP2K1 Gene

Localization for MAP2K1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP2K1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Cytoplasm. Nucleus. Membrane; Peripheral membrane protein. Note=Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during telophase/cytokinesis (PubMed:14737111). Membrane localization is probably regulated by its interaction with KSR1 (PubMed:10409742). {ECO:0000269 PubMed:10409742, ECO:0000269 PubMed:14737111}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP2K1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
golgi apparatus 5
endosome 5
cytoskeleton 4
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MAP2K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 19565474
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion TAS 19565474
GO:0005769 early endosome TAS 19565474
GO:0005770 late endosome TAS 19565474
genes like me logo Genes that share ontologies with MAP2K1: view

Pathways & Interactions for MAP2K1 Gene

SuperPathways for MAP2K1 Gene

SuperPathway Contained pathways
1 RET signaling
2 Activated TLR4 signalling
3 IL-2 Pathway
4 Regulation of lipid metabolism Insulin signaling-generic cascades
5 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
genes like me logo Genes that share pathways with MAP2K1: view

Pathways by source for MAP2K1 Gene

SIGNOR curated interactions for MAP2K1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAP2K1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity TAS 19565474
GO:0001932 regulation of protein phosphorylation IEA --
GO:0006468 protein phosphorylation IEA --
GO:0006928 movement of cell or subcellular component TAS 10912793
genes like me logo Genes that share ontologies with MAP2K1: view

Drugs & Compounds for MAP2K1 Gene

(142) Drugs for MAP2K1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Trametinib Approved Pharma inhibitor, Biomarker, Target MEK 1/2 inhibitor, MEK Inhibitors, Kinase Inhibitors, Mitogen-activated protein/extracellular signal-regulated kinase (MEK) inhibitors 131
cobimetinib Approved Pharma Target, inhibitor Selective MEK inhibitor 0
Mekinist Approved May of 2013 Pharma Inhibition 0
bosutinib Approved Pharma Target, inhibitor Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 0
Sorafenib Approved, Investigational Pharma inhibitors, inhibitor Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 700

(49) Additional Compounds for MAP2K1 Gene - From: Novoseek, Tocris, and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
U0126
109511-58-2

(5) Tocris Compounds for MAP2K1 Gene

Compound Action Cas Number
BIX 02189 Selective MEK5 and ERK5 inhibitor 1265916-41-3
PD 0325901 Potent inhibitor of MEK1/2 391210-10-9
PD 98059 MEK inhibitor 167869-21-8
SL 327 Selective inhibitor of MEK1 and MEK2; brain penetrant 305350-87-2
U0126 Potent, selective inhibitor of MEK1 and 2 109511-58-2

(37) ApexBio Compounds for MAP2K1 Gene

Compound Action Cas Number
10Z-Hymenialdisine 82005-12-7
Arctigenin Anti-inflammatory, antiproliferative 7770-78-7
AZD6244 (Selumetinib) MEK inhibitor 606143-52-6
AZD8330 MEK 1/2 inhibitor 869357-68-6
BI-847325 dual inhibitor of MEK and Aurora kinases 1207293-36-4
BIX 02188 MEK5 inhibitor,potent and selective 1094614-84-2
BIX 02189 Selective MEK5 inhibitor 1094614-85-3
Cobimetinib Selective MEK inhibitor 934660-93-2
Cobimetinib (racemate) Selective MEK inhibitor 934662-91-6
Cobimetinib (R-enantiomer) Selective MEK inhibitor 934660-94-3
FR 180204 ERK inhibitor 865362-74-9
GDC-0623 MEK1 inhibitor, potent and ATP-uncompetitive 1168091-68-6
GDC-0994 ERK1/2 inhibitor 1453848-26-4
MEK inhibitor Potent MEK inhibitor, Antitumor agent 334951-92-7
MEK Inhibitor Set For phosphorylation and dephosphorylation applications
MEK162 (ARRY-162, ARRY-438162) MEK1/2 inhibitor,potent and selective 606143-89-9
PD 198306 MEK inhibitor 212631-61-3
PD 334581 548756-68-9
PD0325901 MEK inhibitor 391210-10-9
PD184352 (CI-1040) Selective MEK inhibitor 212631-79-3
PD318088 Allosteric MEK1/2 inhibitor, non-ATP competitive 391210-00-7
PD98059 MEK inhibitor,selective and reversible 167869-21-8
Pimasertib (AS-703026) MEK1/2 inhibitor 1236699-92-5
Refametinib MEK 1/ MEK 2 inhibitor 923032-37-5
Refametinib R enantiomer MEK1/2 allosteric inhibitor 923032-38-6
RO4987655 MEK inhibitor 874101-00-5
RO5126766(CH5126766) Raf/MEK dual inhibitor 946128-88-7
SCH772984 ERK1 and ERK2 inhibitor 942183-80-4
SCH772984 HCl
SCH772984 TFA
SL-327 Selective MEK1/2 inhibitor 305350-87-2
TAK-733 MEK allosteric site inhibitor 1035555-63-5
Trametinib (GSK1120212) MEK1 and MEK2 inhibitor, potent and selective 871700-17-3
Trametinib DMSO solvate Allosteric MEK1/MEK2 kinase inhibitor 1187431-43-1
U0124 108923-79-1
U0126-EtOH MEK1/2 inhibitor 1173097-76-1
Vemurafenib (PLX4032, RG7204) BRAF kinase inhibitor 918504-65-1
genes like me logo Genes that share compounds with MAP2K1: view

Drug Products

Transcripts for MAP2K1 Gene

Unigene Clusters for MAP2K1 Gene

Mitogen-activated protein kinase kinase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K1 Gene

No ASD Table

Relevant External Links for MAP2K1 Gene

GeneLoc Exon Structure for
MAP2K1
ECgene alternative splicing isoforms for
MAP2K1

Expression for MAP2K1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP2K1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAP2K1 Gene

This gene is overexpressed in Frontal cortex (12.5), Bone marrow mesenchymal stem cell (10.0), and Brain (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP2K1 Gene



Protein tissue co-expression partners for MAP2K1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAP2K1 Gene:

MAP2K1

SOURCE GeneReport for Unigene cluster for MAP2K1 Gene:

Hs.145442

mRNA Expression by UniProt/SwissProt for MAP2K1 Gene:

Q02750-MP2K1_HUMAN
Tissue specificity: Widely expressed, with extremely low levels in brain.

Evidence on tissue expression from TISSUES for MAP2K1 Gene

  • Liver(4.6)
  • Blood(4.5)
  • Nervous system(3.5)
  • Heart(3.2)
  • Muscle(3.1)
  • Intestine(2.9)
  • Kidney(2.8)
  • Lung(2.7)
  • Adrenal gland(2.5)
  • Skin(2.5)
  • Stomach(2.5)
  • Bone marrow(2.3)
  • Lymph node(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP2K1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • meninges
  • mouth
  • neck
  • nose
  • outer ear
  • scalp
  • skull
  • tongue
  • tooth
Thorax:
  • aorta
  • chest wall
  • clavicle
  • esophagus
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • intestine
  • kidney
  • large intestine
  • spleen
  • stomach
Pelvis:
  • pelvis
  • placenta
  • rectum
  • testicle
  • ureter
  • uterus
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • sweat gland
  • vertebrae
genes like me logo Genes that share expression patterns with MAP2K1: view

Primer Products

No data available for mRNA differential expression in normal tissues for MAP2K1 Gene

Orthologs for MAP2K1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAP2K1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP2K1 34 35
  • 98.64 (n)
oppossum
(Monodelphis domestica)
Mammalia MAP2K1 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAP2K1 34 35
  • 94.49 (n)
dog
(Canis familiaris)
Mammalia MAP2K1 34 35
  • 94.25 (n)
rat
(Rattus norvegicus)
Mammalia Map2k1 34
  • 91.26 (n)
mouse
(Mus musculus)
Mammalia Map2k1 34 16 35
  • 90.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAP2K1 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP2K1 34 35
  • 81.51 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 81 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia map2k1 34
  • 78.12 (n)
Str.10686 34
African clawed frog
(Xenopus laevis)
Amphibia mek-2-prov 34
zebrafish
(Danio rerio)
Actinopterygii map2k1 34 35
  • 76.41 (n)
Dr.25154 34
fruit fly
(Drosophila melanogaster)
Insecta Dsor1 36 34 35
  • 64.62 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001103 34
  • 61.1 (n)
worm
(Caenorhabditis elegans)
Secernentea mek-2 36 34 35
  • 52.46 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBS2 35
  • 22 (a)
OneToMany
STE7 37
thale cress
(Arabidopsis thaliana)
eudicotyledons MEK1 34
  • 51.19 (n)
rice
(Oryza sativa)
Liliopsida Os06g0147800 34
  • 49.4 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8484 35
  • 65 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU04612 34
  • 56.14 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes byr1 34
  • 49.9 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.141 34
Species where no ortholog for MAP2K1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP2K1 Gene

ENSEMBL:
Gene Tree for MAP2K1 (if available)
TreeFam:
Gene Tree for MAP2K1 (if available)

Paralogs for MAP2K1 Gene

Paralogs for MAP2K1 Gene

Pseudogenes.org Pseudogenes for MAP2K1 Gene

genes like me logo Genes that share paralogs with MAP2K1: view

Variants for MAP2K1 Gene

Sequence variations from dbSNP and Humsavar for MAP2K1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs121908594 Pathogenic, Cardiofaciocutaneous syndrome 3 (CFC3) [MIM:615279] 66,435,104(+) GGCCT(C/T)TCTTA reference, missense
rs121908595 Pathogenic, Cardiofaciocutaneous syndrome 3 (CFC3) [MIM:615279] 66,436,843(+) CTTCT(A/G)TGGTG reference, missense
rs730880508 Cardiofaciocutaneous syndrome 3 (CFC3) [MIM:615279]
rs121908596 Pathogenic 66,436,837(+) CGTGG(G/T)CTTCT reference, missense
rs397516792 Pathogenic 66,436,825(+) CTCTC(C/G/T)GTACA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MAP2K1 Gene

Variant ID Type Subtype PubMed