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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP2K1 Gene

protein-coding   GIFtS: 76
GCID: GC15P066679

mitogen-activated protein kinase kinase 1


(Previous symbol: PRKMK1)
 Explore 93 diseases affiliated with
MAP2K1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAP2K1    

Aliases
for MAP2K1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitogen-Activated Protein Kinase Kinase 11 2     MAPK/ERK Kinase 12 3
MEK11 2 3 5     MAPKK 12 3
PRKMK11 2 3 5     MEK 12 3
MKK12 3 5     EC 2.7.12.23 8
MAPKK11 2     Dual Specificity Mitogen-Activated Protein Kinase Kinase 12
ERK Activator Kinase 12 3     Protein Kinase, Mitogen-Activated, Kinase 1 (MAP Kinase Kinase 1)2
MAP Kinase Kinase 12 3     

External Ids:    HGNC: 68401   Entrez Gene: 56042   Ensembl: ENSG000001690327   OMIM: 1768725   UniProtKB: Q027503   

Export aliases for MAP2K1 gene to outside databases

Previous GC identifers: GC15U990039 GC15P059778 GC15P064258 GC15P064395 GC15P064356 GC15P064466 GC15P043515


Summaries
for MAP2K1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAP2K1:
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a
mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases
(ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases
and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an
essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such
as proliferation, differentiation, transcription regulation and development. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MP2K1_HUMAN, Q02750
Function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction
pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface
receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein
kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade,
and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located
in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further
transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates
diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the
regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is
peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and
apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the
regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling
compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis

Gene Wiki entry for MAP2K1


Genomic Views
for MAP2K1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP2K1 gene promoter:
         COUP-TF1   COUP   USF-1:USF-2   HNF-4alpha2   HNF-4alpha1   COUP-TF   STAT3   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAP2K1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP2K1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP2K1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.1-q22.33   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.1-q22.33

MAP2K1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP2K1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P066679:  view genomic region     (about GC identifiers)

Start:
 66,679,155 bp from pter      End:
 66,784,754 bp from pter
Size:
 105,600 bases      Orientation:
 plus strand

Proteins
for MAP2K1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MP2K1_HUMAN, Q02750 (See protein sequence)
Recommended Name: Dual specificity mitogen-activated protein kinase kinase 1  
Size: 393 amino acids; 43439 Da
Subunit: Found in a complex with at least BRAF, HRAS1, MAP2K1, MAPK3/ERK1 and RGS14 (By similarity). Forms a
heterodimer with MAP2K2/MEK2 (By similarity). Forms heterodimers with KSR2 which further dimerize to form tetramers
(By similarity). Interacts with ARBB2, LAMTOR3, MAPK1/ERK2, MORG1 and RAF1 (By similarity). Interacts with PPARG and
with isoform 1 of VRK2. Interacts with Yersinia yopJ. Interacts with SGK1. Interacts with BIRC6/bruce
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole body. Cytoplasm.
Nucleus. Note=Localizes at centrosomes during prometaphase, midzone during anaphase and midbody during
telophase/cytokinesis
6/23 PDB 3D structures from and Proteopedia for MAP2K1 (see all 23):
1S9J (3D)        2P55 (3D)        3DV3 (3D)        3DY7 (3D)        3E8N (3D)        3EQB (3D)    
Alternative splicing: 2 isoforms:  Q02750-1   Q02750-2   

Explore the universe of human proteins at neXtProt for MAP2K1: NX_Q02750

Post-translational modifications:

  • Phosphorylation at Ser-218 and Ser-222 by MAP kinase kinase kinases (RAF or MEKK1) positively regulates kinase
    • activity. Also phosphorylated at Thr-292 by MAPK1/ERK2 and at Ser-298 by PAK. MAPK1/ERK2 phosphorylation of Thr-292
    occurs in response to cellular adhesion and leads to inhibition of Ser-298 phosphorylation by PAK1
  • Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q02750

    • 4/21 DME Specific Peptides for MAP2K1 (Q02750) (see all 21)
     CNSPYIV  HAFIKRS  ELELDEQQ  LNQPSTPT 

    MAP2K1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002746.1  
    ENSEMBL proteins: 
     ENSP00000302486   ENSP00000456438  
    Reactome Protein details: Q02750
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant MAP2K1 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for MAP2K1
    OriGene Purified Protein: MAP2K1
    OriGene Protein Over-expression Lysate: MAP2K1
    OriGene Custom Protein Services for MAP2K1 
    GenScript Purified and Recombinant Proteins for MAP2K1
    Novus Biologicals MAP2K1 Proteins
    Novus Biologicals MAP2K1 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for MAP2K1
    Uscn Proteins for MAP2K1

    Gene Ontology (GO): 5/18 cellular component terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005634nucleus TAS19565474
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion TAS19565474
    GO:0005769early endosome TAS19565474


    MAP2K1 for ontologies           About GeneDecksing



    MAP2K1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP2K1
    R&D Systems Antibodies for MAP2K1 (MEK1)
    Cell Signaling Technology (CST) Antibodies for MAP2K1  (MEK1)
    OriGene Antibodies (see all 53): MAP2K1
    OriGene Custom Antibody Services for MAP2K1 
    GenScript Custom Superior Antibodies Services for MAP2K1
    Novus Biologicals MAP2K1 Antibodies
    Abcam antibodies for MAP2K1 
    Uscn Antibodies for MAP2K1
    ThermoFisher Antibody for MAP2K1

    Assay Products for MAP2K1: 
    EMD Millipore Kits and Assays for the Analysis of MAP2K1
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for MAP2K1 (MEK1)
    GenScript MAP2K1-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAP2K1 (MEK1)
    Enzo Life Sciences assays for MAP2K1
    Uscn ELISAs and CLIAs for MAP2K1

    Protein Domains /
    Families
    for MAP2K1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAP2K1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q02750

    ProtoNet protein and cluster: Q02750

    UniProtKB/Swiss-Prot: MP2K1_HUMAN, Q02750
    Domain: The proline-rich region localized between residues 270 and 307 is important for binding to RAF1 and activation
    of MAP2K1/MEK1 (By similarity)
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for MAP2K1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MP2K1_HUMAN, Q02750
    Function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction
    pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface
    receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein
    kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade,
    and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located
    in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further
    transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates
    diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the
    regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is
    peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and
    apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the
    regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling
    compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Ras proteins such as HRAS mediate the activation of RAF proteins such as RAF1 or BRAF which in turn
    activate extracellular signal-regulated kinases (ERK) through MAPK (mitogen-activated protein kinases) and ERK kinases
    MAP2K1/MEK1 and MAP2K2/MEK2. Activation occurs through phosphorylation of Ser-218 and Ser-222. MAP2K1/MEK1 is also the
    target of negative feed-back regulation by its substrate kinases, such as MAPK1/ERK2. These phosphorylate MAP2K1/MEK1
    on Thr-292, thereby facilitating dephosphorylation of the activating residues Ser-218 and Ser-222. Inhibited by
    serine/threonine phosphatase 2A (By similarity). Many inhibitors have been identified including pyrrole derivatives,
    TAK-733 (one of a series of 8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione derivatives), CH4987655 and RDEA119/BAY
    869766

         Genatlas biochemistry entry for MAP2K1:
    mitogen-activated protein kinase kinase 1,nucleocytoplasmic shuttling protein,involved in signal transduction

    Enzyme Number (IUBMB): EC 2.7.12.21 2

    miRNA
    Products:            		miRTarBase miRNAs that target MAP2K1:
    hsa-mir-424 (MIRT003226), hsa-mir-34a (MIRT004483)

    OriGene 3'-UTR Clone: MAP2K1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP2K1
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP2K1 (see all 29):
    hsa-miR-181c hsa-miR-411 hsa-miR-15a hsa-miR-485-3p hsa-miR-503 hsa-miR-1271 hsa-miR-624* hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmid: MAP2K1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP2K1 (see all 7)
    OriGene shRNA RFP: MAP2K1
    OriGene siRNA: MAP2K1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP2K1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAP2K1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP2K1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP2K1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MAP2K1 (NM_002755)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP2K1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP2K1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MAP2K1
    Search LifeMap BioReagents cell lines for MAP2K1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2K1

    Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS10570282
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004708MAP kinase kinase activity IDA8388392
    GO:0004712protein serine/threonine/tyrosine kinase activity TAS19565474
    GO:0004713protein tyrosine kinase activity IEA--


    MAP2K1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for MAP2K1:
     Gemcitabine induced cell-death  Synthetic lethal with Ras  Synthetic lethal/sick with VHL 

    Animal Models:
         Mouse knock-out Map2k1tm1.1Chrn for MAP2K1
         12 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Map2k1):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size  hearing/vestibular/ear  homeostasis/metabolism  integument  mortality/aging 
     reproductive system  vision/eye 

    MAP2K1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAP2K1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/163 super-pathways (see all 163) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_CNTF receptor signaling
    8/22 pathways (see all 22)
    		Development_CNTF receptor signaling1.00
    		Development Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    		Development CNTF receptor signaling1.00
    		Translation _Regulation of EIF4F activity0.32
    		Transcription Receptor-mediated HIF regulation0.43
    		Translation Regulation activity of EIF4F0.32
    		Transcription_Receptor-mediated HIF regulation0.43
    		ErbB2/ErbB3 signaling events0.31
    2TRAF6 Mediated Induction of proinflammatory cytokines
    8/19 pathways (see all 19)
    		TRAF6 Mediated Induction of proinflammatory cytokines1.00
    		Toll Like Receptor TLR1:TLR2 Cascade0.78
    		MAP kinase activation in TLR cascade0.88
    		Toll Like Receptor 2 (TLR2) Cascade0.78
    		Toll Like Receptor 5 (TLR5) Cascade0.86
    		MyD88:Mal cascade initiated on plasma membrane0.78
    		Toll Like Receptor 10 (TLR10) Cascade0.86
    		TRIF-mediated TLR3/TLR4 signaling 0.73
    3Development HGF signaling pathway
    8/17 pathways (see all 17)
    		Development HGF signaling pathway1.00
    		Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR10.24
    		Development_HGF signaling pathway0.78
    		Apoptosis and survival Anti-apoptotic action of membrane-bound ESR10.24
    		Development_Neurotrophin family signaling0.45
    		Apoptosis and survival_Role of CDK5 in neuronal death and survival0.24
    		Development Neurotrophin family signaling0.45
    		Apoptosis and survival Role of CDK5 in neuronal death and survival0.24
    4IL-9 Signaling Pathways
    8/14 pathways (see all 14)
    		IL-9 Signaling Pathways1.00
    		IL-9 Signaling Pathway0.42
    		IL-21 Signaling Pathways0.90
    		Immune response_IL-9 signaling pathway0.42
    		IL-7 Signaling Pathways0.90
    		Immune response IL-9 signaling pathway0.42
    		Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    		IL-7 Signaling Pathway0.38
    5ErbB4 Pathway
    8/13 pathways (see all 13)
    		ErbB4 Pathway1.00
    		LPS Stimulated MAPK Signaling0.36
    		ErbB Family Pathway0.59
    		VEGF Signaling Pathway0.35
    		Prolactin Signaling0.54
    		TREM1 Pathway0.32
    		ErbB2-ErbB3 Heterodimers0.47
    		HMGB1 Pathway0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/80 EMD Millipore Pathways for MAP2K1 (see all 80)
        Chemotaxis CXCR4 signaling pathway
    Translation Translation regulation by Alpha-1 adrenergic receptors
    Development Activation of ERK by Alpha-1 adrenergic receptors
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling FAK signaling

    5/9 R&D Systems Pathways for MAP2K1 (see all 9)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    IL-7 Signaling Pathways

    5/103 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MAP2K1 (see all 103)
        UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    CDK5 Pathway
    PACAP Signaling

    1 Cell Signaling Technology (CST) Pathway for MAP2K1
        MAP Kinase Signaling

    5 Tocris Bioscience Pathways for MAP2K1
        Insulin Pathway
    Apoptosis Pathway
    Toll-like Receptor Pathway
    VEGF Pathway
    MAPK Pathway

    5/82 GeneGo (Thomson Reuters) Pathways for MAP2K1 (see all 82)
        Development A2A receptor signaling
    Development CNTF receptor signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Immune response IL-9 signaling pathway

    5/62 BioSystems Pathways for MAP2K1 (see all 62) 
        MicroRNAs in cardiomyocyte hypertrophy
    AGE/RAGE pathway
    Serotonin Receptor 4/6/7 and NR3C Signaling
    EGFR1 Signaling Pathway
    MAPK signaling pathway

    5/76        Reactome Pathways for MAP2K1 (see all 76)
        Toll Like Receptor 2 (TLR2) Cascade
    SHC-related events
    Toll Like Receptor TLR6:TLR2 Cascade
    Signal transduction by L1
    Toll Like Receptor 3 (TLR3) Cascade

    4 PharmGKB Pathways for MAP2K1
        EGFR Inhibitor Pathway, Pharmacodynamics
    Sorafenib Pharmacodynamics
    VEGF Signaling Pathway
    Vemurafenib Pathway, Pharmacodynamics

    5/40         Kegg Pathways  (Kegg details for MAP2K1) (see all 40):
        MAPK signaling pathway
    ErbB signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis
    Vascular smooth muscle contraction


    MAP2K1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP2K1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/136 Interacting proteins for MAP2K1 (Q027501, 2, 3 ENSP000003024864) via UniProtKB, MINT, STRING, and/or I2D (see all 136)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK3P273612, 3, ENSP000002630254MINT-7014406 MINT-7014390 I2D: score=6 STRING: ENSP00000263025
    MAPK1P284822, 3, ENSP000002158324MINT-8412403 MINT-4300484 I2D: score=13 STRING: ENSP00000215832
    MAP3K1Q132332, 3, ENSP000003824234MINT-3391583 I2D: score=6 STRING: ENSP00000382423
    BIRC6Q9NR091, 3, ENSP000003935964EBI-492564,EBI-1765160 I2D: score=2 STRING: ENSP00000393596
    RAF1P040491, 2, 3, ENSP000002518494EBI-492564,EBI-365996 MINT-7014315 MINT-7014406 MINT-7014341 MINT-7014370 MINT-7014294 I2D: score=8 STRING: ENSP00000251849
    About this table

    Gene Ontology (GO): 5/55 biological process terms (GO ID links to tree view) (see all 55):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade TAS--
    GO:0000186activation of MAPKK activity TAS--
    GO:0000187activation of MAPK activity TAS--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--


    MAP2K1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAP2K1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP2K1 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAP2K1:
    Small Molecule - inhibitor
    Enzo Life Sciences drugs & compounds for MAP2K1

    Compounds for MAP2K1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PD 0325901Selective inhibitor of MEK1/2[391210-10-9]
    PD 98059Specific inhibitor of MEK[167869-21-8]
    U0126 Potent, selective inhibitor of MEK1 and 2 [109511-58-2]
    PD 184352Selective MEK inhibitor[212631-79-3]
    SL 327Selective inhibitor of MEK1 and MEK2; brain penetrant[305350-87-2]

    2 HMDB Compounds for MAP2K1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    7 DrugBank Compounds for MAP2K1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-Bromo-N-(2,3-Dihydroxypropoxy)-3,4-Difluoro-2-[(2-Fluoro-4-Iodophenyl)Amino]Benzamide-- --target--17139284 17016423
    (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide-- --target--10592235
    2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide-- --target--10592235
    2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE-- --target--10592235
    K-252a-- 97161-97-2target--10592235
    N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine-- --target--10592235
    N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide-- --target--10592235

    10/120 Novoseek chemical compound relationships for MAP2K1 gene (see all 120)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pd 98,059 94 307 11166731 (3), 11062749 (2), 15666830 (2), 17448503 (2) (see all 99)
    pd-184352 82.5 11 18071319 (1), 14737074 (1), 11478941 (1), 14611643 (1) (see all 11)
    sb 203580 80.5 48 10903976 (2), 12603864 (2), 11279606 (1), 11278744 (1) (see all 44)
    ly294002 75.7 36 15728510 (2), 11145583 (1), 15896333 (1), 18093851 (1) (see all 34)
    hymenialdisine 74.3 3 15261294 (1), 15123286 (1)
    wortmannin 72.7 35 10362361 (1), 15647842 (1), 11145583 (1), 12812995 (1) (see all 33)
    phosphatidylinositol 69.3 35 8816388 (2), 10748192 (1), 11602589 (1), 10433520 (1) (see all 29)
    cl 100 68.5 1 10473620 (1)
    tyrosine 67.1 52 8034695 (2), 8816388 (2), 7935374 (2), 17348861 (2) (see all 44)
    u0126 63.5 4 18339970 (1), 9917510 (1), 17348861 (1), 16848763 (1)

    Search CenterWatch for drugs/clinical trials and news about MAP2K1 / MP2K1 

    Transcripts
    for MAP2K1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAP2K1 gene: 
    NM_002755.3  

    Unigene Cluster for MAP2K1:

    Mitogen-activated protein kinase kinase 1
    Hs.145442  [show with all ESTs]
    Unigene Representative Sequence: NM_002755
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307102(uc010bhq.3 uc010ujp.2) ENST00000425818 ENST00000566326


    miRNA
    Products:             		 OriGene 3'-UTR Clone: MAP2K1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP2K1
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP2K1 (see all 29):
    hsa-miR-181c hsa-miR-411 hsa-miR-15a hsa-miR-485-3p hsa-miR-503 hsa-miR-1271 hsa-miR-624* hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmid: MAP2K1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP2K1 (see all 7)
    OriGene shRNA RFP: MAP2K1
    OriGene siRNA: MAP2K1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP2K1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP2K1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP2K1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MAP2K1 (NM_002755)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP2K1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP2K1 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAP2K1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP2K1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP2K1

    Additional cDNA sequence: 

    AK291500.1 AK294322.1 AK312356.1 BC137459.1 BC139729.1 L05624.1 L11284.1 

    10 DOTS entries:

    DT.455033  DT.100767185  DT.40208172  DT.86839842  DT.92427870  DT.95135709  DT.99988492  DT.121070750 
    DT.95107632  DT.121478711 

    24/190 AceView cDNA sequences (see all 190):

    BQ672185 AI168089 CD366056 AA313567 N41547 CF145610 AA291125 BM697824 
    AI823439 AA291316 AA322392 F10691 CR604502 BQ707666 AI685483 CB164273 
    BU633889 BU076740 AA364191 BU625166 CA419665 CA449905 CF529451 AV658452 

    GeneLoc Exon Structure


    Expression
    for MAP2K1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP2K1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATAGCTGGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAP2K1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MAP2K1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP2K1

    SOURCE GeneReport for Unigene cluster: Hs.145442

    UniProtKB/Swiss-Prot: MP2K1_HUMAN, Q02750
    Tissue specificity: Widely expressed, with extremely low levels in brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAP2K1 (see all 13): 
              Insulin Signaling Pathway in human mouse rat
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Cancer PathwayFinder in human mouse rat
              VEGF Signaling in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP2K1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2K1

    Orthologs
    for MAP2K1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAP2K1 gene from 8/31 species (see all 31)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAP2K11 mitogen-activated protein kinase kinase 1 81.51(n)
    95.93(a)    		   415549  NM_001005830.1  NP_001005830.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia mek-2-prov2 MAP kinase kinase or Erk Kinase, Dual specificity mitogen-activated more 79.34(n)    BC043913.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.251542 Danio rerio cDNA clone MGC56557 IMAGE5914655, complete more 79.39(n)    BC052120.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Dsor11 , 3 signal transduction receptor signaling
    protein more3
    Downstream of raf11    		 66(a)3
    64.62(n)1
    67.88(a)1    		   1 8D103
    318721  NM_078543.41  NP_511098.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea mek-21 , 3 protein kinase3
    Protein MEK-21    		 52(a)3
    52.79(n)1
    55.14(a)1    		   I(3006030-3013446)3
    1718721  NM_058686.31  NP_491087.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes STE7(YDL159W)4
    STE71    		 Signal transducing MAP kinase kinase involved in pheromone more4
    Ste7p1    		 51.08(n)1
    41.8(a)1    		   4(172481-174028)4
    8513961, 4  NP_010122.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MKK21 mitogen-activated protein kinase kinase 2 49.76(n)
    43.88(a)    		   829103  NM_001036674.1  NP_001031751.1 
    rice
    (Oryza sativa)    		 Liliopsida Os06g01478001 hypothetical protein 49.63(n)
    43.01(a)    		   4340126  NM_001063341.1  NP_001056806.1 


    ENSEMBL Gene Tree for MAP2K1 (if available)
    TreeFam Gene Tree for MAP2K1 (if available) 

    Paralogs
    for MAP2K1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP2K1 gene
    MAP2K32  MAP2K52  MAP2K22  MAP2K62  MAP2K42  MAP2K72  
    18/22 SIMAP similar genes for MAP2K1 using alignment to 4 protein entries:     MP2K1_HUMAN (see all proteins) (see all similar genes):
    DKFZp686L02273    MAP2K2    NEK9    STK25    MAP2K5    CCRK
    RPS6KA2    NEK6    MARK4    MAP2K7    MAP2K3    MAP2K6
    RPS6KA3    STK11    STK4    STK3    MAP2K4    MYO3A

    MAP2K1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MAP2K1
    PGOHUM00000249607


    Genomic Variants
    for MAP2K1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1900 NCBI SNPs in MAP2K1 are shown (see all 1900)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2011192081,2
    		--66677278(+) AAACA-/CCCCCC 1 -- us2k10--------
    rs1826372051,2
    		--66677282(+) CACCCC/TCCCAA 1 -- us2k10--------
    rs679303091,2
    		C,--66677332(+) ATTCCA/CATACA 1 -- us2k14Minor allele frequency- C:0.15NA EA 244
    rs1865656311,2
    		--66677333(+) TTCCAA/GTACAA 1 -- us2k10--------
    rs1415931491,2
    		--66677343(+) ATAGCA/GTAAGG 1 -- us2k10--------
    rs99442731,2
    		C,--66677374(+) CTAACT/GTCATT 1 -- us2k1 tfbs311Minor allele frequency- G:0.07NA WA CSA 137
    rs1925192461,2
    		--66677431(+) GACTTA/GATCAA 1 -- us2k10--------
    rs1508981401,2
    		--66677441(+) ACCATC/TCTGAA 1 -- us2k10--------
    rs759824591,2
    		--66677443(+) CATCCT/GGAATG 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1398929611,2
    		--66677457(+) CTAACC/TTCCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAP2K1 (66679155 - 66784754 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MAP2K1: --
    Human Gene Mutation Database (HGMD): MAP2K1

    Locus Specific Mutation Databases (LSDB): MAP2K1

    4 SABiosciences Cancer Mutation PCR Assays for MAP2K1:
    Cosmic IdAA Change
    99000001D67N
    99000004K57N
    99000002Q56P
    99000003P124L
    5/11 SABiosciences Cancer Mutation PCR Arrays containing MAP2K1 (see all 11):
    Receptor Tyrosine Kinase (RTK) (Panel II)
    ErbB2/HER2/neu Pathway
    FGFR Pathway
    FLT3 Pathway
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP2K1
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP2K1

    Disorders / Diseases
    for MAP2K1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAP2K1 for disorders           About GeneDecksing

    OMIM gene information: 176872   
    OMIM disorders: 115150  
    UniProtKB/Swiss-Prot: MP2K1_HUMAN, Q02750
  • Defects in MAP2K1 are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as
    • cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and
    mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy.
    Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin
    lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They
    include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures,
    a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is
    autosomal dominant

    20/93 diseases for MAP2K1 (see all 93):    About MalaCards
    high blood pressure    short stature    pulmonic stenosis    noonan syndrome
    achondroplasia    burkitt's lymphoma    cardiofaciocutaneous syndrome    barrett's esophagus
    myeloid leukemia    insulin resistance    costello syndrome    leopard syndrome
    acute promyelocytic leukemia    dwarfism    anaplastic meningioma    hypertrophic cardiomyopathy
    carcinoma    chronic myeloid leukemia    acute myeloid leukemia    herpes simplex

    2 diseases from the University of Copenhagen DISEASES database for MAP2K1:
    Costello syndrome     Noonan syndrome

    10/53 Novoseek disease relationships for MAP2K1 gene (see all 53)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cfc syndrome 88.6 7 20052757 (1), 17211612 (1), 17551924 (1), 17661820 (1) (see all 7)
    noonan syndrome 68.1 4 19156172 (1), 17056636 (1), 17603483 (1)
    anthrax 43 3 18350154 (1), 15843553 (1), 15146199 (1)
    tumors 37.9 45 19462441 (4), 18243508 (3), 11145953 (2), 9223425 (2) (see all 30)
    leukemia 35.5 4 14706142 (1), 12970778 (1), 9613107 (1), 15031205 (1)
    heart defects congenital 29.3 1 19376813 (1)
    cancer 28.6 17 14598883 (1), 12007959 (1), 12510150 (1), 17551924 (1) (see all 13)
    pancreatic cancer 28 6 20514469 (4), 14598883 (1), 19929921 (1)
    colon cancer 23.4 4 19411838 (2), 17667937 (1)
    achondroplasia 22.1 4 16463380 (3)

    GeneTests: MAP2K1
    Cardiofaciocutaneous Syndrome

    Human Genome Epidemiology (HuGE) Navigator: MAP2K1 (9 documents)

    Export disorders for MAP2K1 gene to outside databases

    Publications
    for MAP2K1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP2K1 gene, integrated from 9 sources (see all 1023):
    (articles sorted by number of sources associating them with MAP2K1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. (PubMed id 8388392)1, 2, 3, 9 Zheng C.-F. and Guan K.-L. (1993)
    2. Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. (PubMed id 15543157)1, 2, 9 Ohren J.F....Hasemann C.A. (2004)
    3. Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5. (PubMed id 9465908)1, 3, 9 Rampoldi L....Danieli G.A. (1997)
    4. Germline mutations in genes within the MAPK pathway cause cardio- facio-cutaneous syndrome. (PubMed id 16439621)1, 2, 9 Rodriguez-Viciana P.... Rauen K.A. (2006)
    5. Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues. (PubMed id 8131746)1, 2, 9 Zheng C.-F. and Guan K.-L. (1994)
    6. Protein kinase SGK1 enhances MEK/ERK complex formatio n through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration. (PubMed id 19447520)1, 2 Won M....Hur G.M. (2009)
    7. The ERK signaling cascade--views from different subcellular compartments. (PubMed id 19565474)1, 2 Yao Z. and Seger R. (2009)
    8. Final stages of cytokinesis and midbody ring formation are controlled by BRUCE. (PubMed id 18329369)1, 2 Pohl C. and Jentsch S. (2008)
    9. Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma. (PubMed id 17101779)1, 2 Burgermeister E....Seger R. (2007)
    10. Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. (PubMed id 16728640)1, 2 Mukherjee S....Orth K. (2006)

    External Searches for MAP2K1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAP2K1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5604 HGNC: 6840 AceView: MAP2K1 Ensembl:ENSG00000169032 euGenes: HUgn5604
    ECgene: MAP2K1 Kegg: 5604 H-InvDB: MAP2K1

    Other Databases showing MAP2K1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAP2K1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP2K1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP2K1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MAP2K1

    Intellectual Property
    for MAP2K1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAP2K1 gene:
    Search GeneIP for patents involving MAP2K1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    Advanced Cell Diagnostics
    About This Section

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