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MAP2K1 Gene

protein-coding   GIFtS: 79
GCID: GC15P066679

Mitogen-Activated Protein Kinase Kinase 1


(Previous symbol: PRKMK1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitogen-Activated Protein Kinase Kinase 11 2     MEK 12 3
PRKMK11 2 3 5     EC 2.7.12.23 8
MEK12 3 5     CFC32 5
MKK12 3 5     MAPKK12
ERK Activator Kinase 12 3     Dual Specificity Mitogen-Activated Protein Kinase Kinase 12
MAPK/ERK Kinase 12 3     Protein Kinase, Mitogen-Activated, Kinase 1 (MAP Kinase Kinase 1)2
MAPKK 12 3     MAP Kinase Kinase 13

External Ids:    HGNC: 68401   Entrez Gene: 56042   Ensembl: ENSG000001690327   OMIM: 1768725   UniProtKB: Q027503   

Export aliases for MAP2K1 gene to outside databases

Previous GC identifers: GC15U990039 GC15P059778 GC15P064258 GC15P064395 GC15P064356 GC15P064466 GC15P043515


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP2K1 Gene:
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a
mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases
(ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP
kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular
signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many
cellular processes such as proliferation, differentiation, transcription regulation and development. (provided by
RefSeq, Jul 2008)

GeneCards Summary for MAP2K1 Gene:
MAP2K1 (mitogen-activated protein kinase kinase 1) is a protein-coding gene. Diseases associated with MAP2K1 include cardiofaciocutaneous syndrome 3, and map2k1-related cardiofaciocutaneous syndrome. GO annotations related to this gene include protein serine/threonine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is MAP2K3.

UniProtKB/Swiss-Prot: MP2K1_HUMAN, Q02750
Function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal
transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their
cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the
dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function
specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine
residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and
MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade.
Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth,
adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and
cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor
gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to
export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics,
including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well
as in the fragmentation of the Golgi apparatus during mitosis

Gene Wiki entry for MAP2K1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP2K1 gene promoter:
         COUP-TF1   COUP   USF-1:USF-2   HNF-4alpha2   HNF-4alpha1   COUP-TF   STAT3   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP2K1 promoter sequence
   Search Chromatin IP Primers for MAP2K1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP2K1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.1-q22.33   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.1-q22.33

MAP2K1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP2K1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P066679:  view genomic region     (about GC identifiers)

Start:
66,679,155 bp from pter      End:
66,784,650 bp from pter
Size:
105,496 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MP2K1_HUMAN, Q02750 (See protein sequence)
Recommended Name: Dual specificity mitogen-activated protein kinase kinase 1  
Size: 393 amino acids; 43439 Da
Subunit: Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3/ERK1 and RGS14 (By similarity). Forms a
heterodimer with MAP2K2/MEK2 (By similarity). Forms heterodimers with KSR2 which further dimerize to form
tetramers (By similarity). Interacts with ARBB2, LAMTOR3, MAPK1/ERK2, MORG1 and RAF1 (By similarity). Interacts
with PPARG and with isoform 1 of VRK2. Interacts with Yersinia yopJ. Interacts with SGK1. Interacts with
BIRC6/bruce
Selected PDB 3D structures from and Proteopedia for MAP2K1 (see all 31):
1S9J (3D)        2P55 (3D)        3DV3 (3D)        3DY7 (3D)        3E8N (3D)        3EQB (3D)    
Alternative splicing: 2 isoforms:  Q02750-1   Q02750-2   

Explore the universe of human proteins at neXtProt for MAP2K1: NX_Q02750

Explore proteomics data for MAP2K1 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-218 and Ser-222 by MAP kinase kinase kinases (RAF or MEKK1) positively regulates kinase
    activity. Also phosphorylated at Thr-292 by MAPK1/ERK2 and at Ser-298 by PAK. MAPK1/ERK2 phosphorylation of
    Thr-292 occurs in response to cellular adhesion and leads to inhibition of Ser-298 phosphorylation by PAK1
  • Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway1
  • Ubiquitination2 at Lys104, Lys192, Lys205, Lys353
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAP2K1 (Q02750) (see all 21)
     CNSPYIV  HAFIKRS  ELELDEQQ  LNQPSTPT 


    See MAP2K1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002746.1  
    ENSEMBL proteins: 
     ENSP00000302486   ENSP00000456438  
    Reactome Protein details: Q02750

    MAP2K1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant MAP2K1 Protein
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for MAP2K1
    OriGene Purified Proteins for MAP2K1
    OriGene Protein Over-expression Lysate for MAP2K1
    OriGene MassSpec for MAP2K1
    OriGene Custom Protein Services for MAP2K1
    GenScript Custom Purified and Recombinant Proteins Services for MAP2K1
    Novus Biologicals MAP2K1 Proteins
    Novus Biologicals MAP2K1 Lysate
    Sino Biological Recombinant Protein for MAP2K1
    Sino Biological Cell Lysate for MAP2K1
    ProSpec Recombinant Protein for MAP2K1
    Cloud-Clone Corp. Proteins for MAP2K1

    MAP2K1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP2K1
    R&D Systems Antibodies for MAP2K1 (MEK1)
    Cell Signaling Technology (CST) Antibodies for MAP2K1  (MEK1)
    OriGene Antibodies for MAP2K1
    OriGene Custom Antibody Services for MAP2K1
    Novus Biologicals MAP2K1 Antibodies
    Abcam antibodies for MAP2K1 (P36507, Q02750, Q02750 )
    Cloud-Clone Corp. Antibodies for MAP2K1
    ThermoFisher Antibody for MAP2K1
    LSBio Antibodies in human, mouse, rat for MAP2K1

    MAP2K1 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of MAP2K1
    OriGene Custom Assay Services for MAP2K1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAP2K1
    Cell Signaling Technology (CST) Sandwich ELISA Kits for MAP2K1 (MEK1)
    Enzo Life Sciences assays for MAP2K1
    Cloud-Clone Corp. ELISAs for MAP2K1
    Cloud-Clone Corp. CLIAs for MAP2K1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MAP2K: Mitogen-activated protein kinase cascade / Kinase kinases

    IUPHAR Guide to PHARMACOLOGY protein family classification: mitogen-activated protein kinase kinase 1
    STE7 family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q02750

    ProtoNet protein and cluster: Q02750

    UniProtKB/Swiss-Prot: MP2K1_HUMAN, Q02750
    Domain: The proline-rich region localized between residues 270 and 307 is important for binding to RAF1 and
    activation of MAP2K1/MEK1 (By similarity)
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase
    subfamily
    Similarity: Contains 1 protein kinase domain


    MAP2K1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MP2K1_HUMAN, Q02750
    Function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal
    transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their
    cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the
    dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function
    specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine
    residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and
    MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade.
    Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth,
    adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and
    cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor
    gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to
    export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics,
    including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well
    as in the fragmentation of the Golgi apparatus during mitosis
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Ras proteins such as HRAS mediate the activation of RAF proteins such as RAF1 or BRAF which in
    turn activate extracellular signal-regulated kinases (ERK) through MAPK (mitogen-activated protein kinases) and
    ERK kinases MAP2K1/MEK1 and MAP2K2/MEK2. Activation occurs through phosphorylation of Ser-218 and Ser-222.
    MAP2K1/MEK1 is also the target of negative feed-back regulation by its substrate kinases, such as MAPK1/ERK2.
    These phosphorylate MAP2K1/MEK1 on Thr-292, thereby facilitating dephosphorylation of the activating residues
    Ser-218 and Ser-222. Inhibited by serine/threonine phosphatase 2A (By similarity). Many inhibitors have been
    identified including pyrrole derivatives, TAK-733 (one of a series of
    8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione derivatives), CH4987655 and RDEA119/BAY 869766

         Genatlas biochemistry entry for MAP2K1:
    mitogen-activated protein kinase kinase 1,nucleocytoplasmic shuttling protein,involved in signal transduction

         Enzyme Number (IUBMB): EC 2.7.12.21 2

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS10570282
    GO:0004674protein serine/threonine kinase activity TAS--
    GO:0004708MAP kinase kinase activity IDA8388392
    GO:0004712protein serine/threonine/tyrosine kinase activity TAS19565474
    GO:0004713protein tyrosine kinase activity IEA--
         
    MAP2K1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MAP2K1:
     Gemcitabine induced cell-death  Synthetic lethal with Ras  Synthetic lethal/sick with VHL 

         Selected MGI mutant phenotypes (inferred from 5 alleles(MGI details for Map2k1) (see all 17):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  homeostasis/metabolism  integument 
     mortality/aging  nervous system  normal  reproductive system  skeleton 

    MAP2K1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MAP2K1: Map2k1tm1.1Bacc Map2k1tm1.1Chrn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAP2K1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAP2K1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP2K1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP2K1

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAP2K1:
    hsa-mir-497-5p (MIRT007165), hsa-mir-181a-5p (MIRT025120), hsa-mir-93-3p (MIRT038788), hsa-mir-30c-5p (MIRT047918), hsa-mir-1826 (MIRT006601), hsa-mir-424-5p (MIRT003226), hsa-mir-101-3p (MIRT027265), hsa-mir-34a-5p (MIRT004483), hsa-mir-128-3p (MIRT022002)

    Block miRNA regulation of human, mouse, rat MAP2K1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP2K1 (see all 29):
    hsa-miR-181c hsa-miR-411 hsa-miR-15a hsa-miR-485-3p hsa-miR-503 hsa-miR-1271 hsa-miR-624* hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidMAP2K1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAP2K1
    Predesigned siRNA for gene silencing in human, mouse, rat MAP2K1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAP2K1

    Clone
    Products:
         
    OriGene clones in human, mouse for MAP2K1 (see all 7)
    OriGene ORF clones in mouse, rat for MAP2K1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAP2K1 (NM_002755)
    Sino Biological Human cDNA Clone for MAP2K1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP2K1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP2K1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAP2K1
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAP2K1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2K1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MP2K1_HUMAN, Q02750: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton,
    microtubule organizing center, spindle pole body. Cytoplasm. Nucleus. Note=Localizes at centrosomes during
    prometaphase, midzone during anaphase and midbody during telophase/cytokinesis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    endosome5
    golgi apparatus5
    mitochondrion5
    nucleus5
    plasma membrane4
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS19565474
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion TAS19565474
    GO:0005769early endosome TAS19565474
    GO:0005770late endosome TAS19565474

    MAP2K1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP2K1 About   (see all 168)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Immune response Fc epsilon RI pathway
    Immune response Fc epsilon RI pathway0.43
    VEGF - VEGF R2 Signaling Pathways0.35
    Fc epsilon RI signaling pathway0.41
    Fc-epsilon receptor I signaling in mast cells0.34
    VEGF signaling pathway0.39
    2IL-9 Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    IL-7 Signaling Pathways0.90
    IL-9 Signaling Pathway0.42
    IL-21 Signaling Pathways0.90
    Immune response IL 9 signaling pathway0.42
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    IL-7 Signaling Pathway0.40
    3Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Cell adhesion PLAU signaling0.35
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Transcription PPAR Pathway0.34
    Transcription Receptor mediated HIF regulation0.51
    Development Growth hormone signaling via PI3K AKT and MAPK cascades0.34
    Translation Regulation activity of EIF20.47
    Insulin signaling pathway0.32
    4Development HGF signaling pathway
    Development HGF signaling pathway0.45
    Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    Development Neurotrophin family signaling0.45
    Neurotrophin signaling pathway0.36
    Development EGFR signaling via small GTPases0.44
    Signaling of Hepatocyte Growth Factor Receptor0.35
    Development PDGF signaling via MAPK cascades0.41
    Apoptosis and survival Anti apoptotic action of membrane bound ESR10.35
    5B cell receptor signaling pathway (KEGG)
    B cell receptor signaling pathway0.42
    T cell receptor signaling pathway0.38
    BCR signaling pathway0.42
    TCR Signaling Pathway0.36

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for MAP2K1 (see all 11)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for MAP2K1 (see all 103)
        UVB-Induced MAPK Signaling
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    CDK5 Pathway
    PACAP Signaling

    1 Cell Signaling Technology (CST) Pathway for MAP2K1
        MAP Kinase Signaling

    5 Tocris Bioscience Pathways for MAP2K1
        Insulin Pathway
    Apoptosis Pathway
    Toll-like Receptor Pathway
    VEGF Pathway
    MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for MAP2K1 (see all 82)
        Development A2A receptor signaling
    Development CNTF receptor signaling
    Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1
    Development EGFR signaling pathway
    Immune response IL-9 signaling pathway

    Selected BioSystems Pathways for MAP2K1 (see all 65)
        Osteopontin Signaling
    MAPK signaling pathway
    MicroRNAs in cardiomyocyte hypertrophy
    Focal Adhesion
    Integrin-mediated cell adhesion

    4 Sino Biological Pathways for MAP2K1
        EGFR Signaling Pathway
    Non-Canonical Wnt Pathway
    VEGF Signaling
    TGF-beta Signaling Pathway

    Selected Reactome Pathways for MAP2K1 (see all 6)
        Interleukin-1 signaling
    ERK1 activation
    Signaling by FGFR
    MEK activation
    Signal transduction by L1

    4 PharmGKB Pathways for MAP2K1
        EGFR Inhibitor Pathway, Pharmacodynamics
    Sorafenib Pharmacodynamics
    VEGF Signaling Pathway
    Vemurafenib Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for MAP2K1) (see all 55):
        MAPK signaling pathway
    ErbB signaling pathway
    Ras signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway


    MAP2K1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP2K1 (see all 13): 
              Insulin Signaling Pathway in human mouse rat
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Cancer PathwayFinder in human mouse rat
              VEGF Signaling in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAP2K1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAP2K1 (Q027501, 2, 3 ENSP000003024864) via UniProtKB, MINT, STRING, and/or I2D (see all 282)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237724P081073, ENSP000004063594I2D: score=1 STRING: ENSP00000406359
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 60):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade TAS--
    GO:0000186activation of MAPKK activity TAS--
    GO:0000187activation of MAPK activity TAS19565474
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--

    MAP2K1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for MAP2K1
    4 ApexBio Compounds for MAP2K1     About this table
    CompoundAction CAS #
    FR 180204Selective ERK inhibitor[865362-74-9]
    VX-11epotent, selective, and orally bioavailable inhibitor of ERK[896720-20-0]
    XMD17-109novel, specific ERK-5 inhibitor with an EC50 4.2uM in HEK293 cells[1435488-37-1]
    XMD8-92highly selective ERK5/BMK1 inhibitor[1234480-50-2]

    Browse Tocris compounds for MAP2K1 (MP2K1)

    2 HMDB Compounds for MAP2K1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    9 DrugBank Compounds for MAP2K1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    5-Bromo-N-(2,3-Dihydroxypropoxy)-3,4-Difluoro-2-[(2-Fluoro-4-Iodophenyl)Amino]Benzamide-- --target--17139284 17016423
    (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide-- --target--10592235
    2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide-- --target--10592235
    2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE-- --target--10592235
    BosutinibBosulif® (see all 3)380843-75-4targetinhibitor19039322
    K-252a-- 97161-97-2target--10592235
    N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine-- --target--10592235
    N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide-- --target--10592235
    Trametinib-- 871700-17-3targetinhibitor23432625

    Selected Novoseek inferred chemical compound relationships for MAP2K1 gene (see all 120)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pd 98,059 94 307 11166731 (3), 11062749 (2), 15666830 (2), 17448503 (2) (see all 99)
    pd-184352 82.5 11 18071319 (1), 14737074 (1), 11478941 (1), 14611643 (1) (see all 11)
    sb 203580 80.5 48 10903976 (2), 12603864 (2), 11279606 (1), 11278744 (1) (see all 44)
    ly294002 75.7 36 15728510 (2), 11145583 (1), 15896333 (1), 18093851 (1) (see all 34)
    hymenialdisine 74.3 3 15261294 (1), 15123286 (1)
    wortmannin 72.7 35 10362361 (1), 15647842 (1), 11145583 (1), 12812995 (1) (see all 33)
    phosphatidylinositol 69.3 35 8816388 (2), 10748192 (1), 11602589 (1), 10433520 (1) (see all 29)
    cl 100 68.5 1 10473620 (1)
    tyrosine 67.1 52 8034695 (2), 8816388 (2), 7935374 (2), 17348861 (2) (see all 44)
    u0126 63.5 4 18339970 (1), 9917510 (1), 17348861 (1), 16848763 (1)



    MAP2K1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for MAP2K1 gene: 
    NM_002755.3  

    Unigene Cluster for MAP2K1:

    Mitogen-activated protein kinase kinase 1
    Hs.145442  [show with all ESTs]
    Unigene Representative Sequence: NM_002755
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307102(uc010bhq.3 uc010ujp.2) ENST00000425818 ENST00000566326

    miRNA
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    Block miRNA regulation of human, mouse, rat MAP2K1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP2K1 (see all 29):
    hsa-miR-181c hsa-miR-411 hsa-miR-15a hsa-miR-485-3p hsa-miR-503 hsa-miR-1271 hsa-miR-624* hsa-miR-449a
    SwitchGear 3'UTR luciferase reporter plasmidMAP2K1 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat MAP2K1
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    OriGene ORF clones in mouse, rat for MAP2K1
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    GenScript: all cDNA clones in your preferred vector: MAP2K1 (NM_002755)
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      QuantiTect SYBR Green Assays in human, mouse, rat MAP2K1
      QuantiFast Probe-based Assays in human, mouse, rat MAP2K1

    Additional mRNA sequence: 

    AK291500.1 AK294322.1 AK312356.1 BC137459.1 BC139729.1 L05624.1 L11284.1 

    10 DOTS entries:

    DT.455033  DT.100767185  DT.40208172  DT.86839842  DT.92427870  DT.95135709  DT.99988492  DT.121070750 
    DT.95107632  DT.121478711 

    Selected AceView cDNA sequences (see all 190):

    D12354 AA291316 BG030108 BX454108 AA313567 AI168089 C04970 AI369328 
    CR621481 T17298 BU633889 AA322392 CR604502 CA307446 BM697824 CF145610 
    CA449919 CB164273 BU076740 AI685483 AV658452 AA291125 AI823439 BE856741 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAP2K1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAGCTGGGG
    MAP2K1 Expression
    About this image


    MAP2K1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Neural Tube (Nervous System)
             Metencephalon
    MAP2K1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP2K1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.145442

    UniProtKB/Swiss-Prot: MP2K1_HUMAN, Q02750
    Tissue specificity: Widely expressed, with extremely low levels in brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP2K1 (see all 13): 
              Insulin Signaling Pathway in human mouse rat
              Antiviral Response in human mouse rat
              Multiple Sclerosis in human mouse rat
              Cancer PathwayFinder in human mouse rat
              VEGF Signaling in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat MAP2K1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2K1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAP2K1 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map2k11 , 5 mitogen-activated protein kinase kinase 11, 5 90.67(n)1
    98.98(a)1
      9 (34.55 cM)5
    263951  NM_008927.31  NP_032953.11 
     641857705 
    chicken
    (Gallus gallus)
    Aves MAP2K11 mitogen-activated protein kinase kinase 1 81.51(n)
    95.93(a)
      415549  NM_001005830.1  NP_001005830.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    81(a)
    many ↔ many
    AAWZ02039589(1152-5061)
    African clawed frog
    (Xenopus laevis)
    Amphibia mek-2-prov2 MAP kinase kinase or Erk Kinase, Dual specificity mitogen-activated more 79.34(n)    BC043913.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.251542 Danio rerio cDNA clone MGC56557 IMAGE5914655, complete more 79.39(n)    BC052120.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dsor11 , 3 signal transduction receptor signaling
    protein more3
    Downstream of raf11
    66(a)3
    64.62(n)1
    67.88(a)1
      1 8D103
    318721  NM_078543.41  NP_511098.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mek-21 , 3 protein kinase3
    mek-21
    52(a)3
    52.46(n)1
    53.89(a)1
      I(3006030-3013446)3
    1718721  NM_058686.41  NP_491087.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STE7(YDL159W)4 Signal transducing MAP kinase kinase involved in pheromone more   --   4(172481-174028) 851396  NP_010122.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MEK11 MEK1 51.19(n)
    43.93(a)
      828713  NM_202890.1  NP_974619.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g01478001 Os06g0147800 49.4(n)
    42.39(a)
      4340126  NM_001063341.1  NP_001056806.1 


    ENSEMBL Gene Tree for MAP2K1 (if available)
    TreeFam Gene Tree for MAP2K1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP2K1 gene
    MAP2K32  MAP2K52  MAP2K22  MAP2K62  MAP2K42  MAP2K72  
    Selected SIMAP similar genes for MAP2K1 using alignment to 4 protein entries:     MP2K1_HUMAN (see all proteins) (see all similar genes):
    DKFZp686L02273    MAP2K2    NEK9    STK25    MAP2K5    CCRK
    RPS6KA2    NEK6    MARK4    MAP2K7    MAP2K3    MAP2K6
    RPS6KA3    STK11    STK4    STK3    MAP2K4    MYO3A

    MAP2K1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MAP2K1
    PGOHUM00000249607


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP2K1 (see all 2311)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0350934
    Cardiofaciocutaneous syndrome 3 (CFC3)4--see VAR_0350932 F S mis40--------
    VAR_0697804
    Cardiofaciocutaneous syndrome 3 (CFC3)4--see VAR_0697802 G V mis40--------
    VAR_0350944
    Cardiofaciocutaneous syndrome 3 (CFC3)4--see VAR_0350942 Y C mis40--------
    rs2011192081,2
    --66677278(+) AAACA-/CCCCCC 1 -- us2k10--------
    rs1826372051,2
    --66677282(+) CACCCC/TCCCAA 1 -- us2k10--------
    rs679303091,2
    C--66677332(+) ATTCCA/CATACA 1 -- us2k14Minor allele frequency- C:0.15NA EA 244
    rs1865656311,2
    C--66677333(+) TTCCAA/GTACAA 1 -- us2k10--------
    rs1415931491,2
    C--66677343(+) ATAGCA/GTAAGG 1 -- us2k10--------
    rs99442731,2
    C--66677374(+) CTAACT/GTCATT 1 -- us2k1 tfbs311Minor allele frequency- G:0.07NA WA CSA 137
    rs1925192461,2
    --66677431(+) GACTTA/GATCAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAP2K1 (66679155 - 66784650 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for MAP2K1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749791CNV Deletion23290073
    dgv455e199CNV Deletion23128226
    esv2749792CNV Deletion23290073
    nsv833045CNV Gain17160897

    Human Gene Mutation Database (HGMD): MAP2K1
    Locus Specific Mutation Databases (LSDB): MAP2K1

    4 Site Specific Mutation Identification with PCR Assays for MAP2K1:
    Cosmic IdAA Change
    99000001D67N
    99000004K57N
    99000002Q56P
    99000003P124L
    Selected Site Specific Cancer Mutation PCR Panels containing MAP2K1 (see all 11):
    Receptor Tyrosine Kinase (RTK) (Panel II)
    ErbB2/HER2/neu Pathway
    FGFR Pathway
    FLT3 Pathway
    SeqTarget long-range PCR primers for resequencing MAP2K1
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP2K1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176872   
    OMIM disorders: 615279  
    UniProtKB/Swiss-Prot: MP2K1_HUMAN, Q02750
  • Cardiofaciocutaneous syndrome 3 (CFC3) [MIM:615279]: A form of cardiofaciocutaneous syndrome, a multiple
    congenital anomaly disorder characterized by a distinctive facial appearance, heart defects and mental
    retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some
    affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin
    lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They
    include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral
    fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. Distinctive features
    of CFC3 include macrostomia and horizontal shape of palpebral fissures. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • Selected diseases for MAP2K1 (see all 91):    
    About MalaCards
    cardiofaciocutaneous syndrome 3    map2k1-related cardiofaciocutaneous syndrome    map2k1-related noonan syndrome    cardiofaciocutaneous syndrome
    costello syndrome    pulmonic stenosis    leopard syndrome    noonan syndrome
    achondroplasia    plasma cell leukemia    dwarfism    balanitis
    polyploidy    drug addiction    prion disease    hepatoblastoma
    embryonal rhabdomyosarcoma    short stature    papilloma    stomach cancer

    2 diseases from the University of Copenhagen DISEASES database for MAP2K1:
    Costello syndrome     Noonan syndrome

    MAP2K1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for MAP2K1 gene (see all 53)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cfc syndrome 88.6 7 20052757 (1), 17211612 (1), 17551924 (1), 17661820 (1) (see all 7)
    noonan syndrome 68.1 4 19156172 (1), 17056636 (1), 17603483 (1)
    anthrax 43 3 18350154 (1), 15843553 (1), 15146199 (1)
    tumors 37.9 45 19462441 (4), 18243508 (3), 11145953 (2), 9223425 (2) (see all 30)
    leukemia 35.5 4 14706142 (1), 12970778 (1), 9613107 (1), 15031205 (1)
    heart defects congenital 29.3 1 19376813 (1)
    cancer 28.6 17 14598883 (1), 12007959 (1), 12510150 (1), 17551924 (1) (see all 13)
    pancreatic cancer 28 6 20514469 (4), 14598883 (1), 19929921 (1)
    colon cancer 23.4 4 19411838 (2), 17667937 (1)
    achondroplasia 22.1 4 16463380 (3)

    GeneTests: MAP2K1
    GeneReviews: MAP2K1
    Genetic Association Database (GAD): MAP2K1
    Human Genome Epidemiology (HuGE) Navigator: MAP2K1 (9 documents)

    Export disorders for MAP2K1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP2K1 gene, integrated from 10 sources (see all 1054):
    (articles sorted by number of sources associating them with MAP2K1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. (PubMed id 8388392)1, 2, 3, 9 Zheng C.-F. and Guan K.-L. (J. Biol. Chem. 1993)
    2. Spectrum of MEK1 and MEK2 gene mutations in cardio-facio-cutaneous syndrome and genotype-phenotype correlations. (PubMed id 19156172)1, 4, 9 Dentici M.L....Dallapiccola B. (Eur. J. Hum. Genet. 2009)
    3. MEK1 and AKT2 mutations in Japanese lung cancer. (PubMed id 20354455)1, 4, 9 Sasaki H....Fujii Y. (J Thorac Oncol 2010)
    4. Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. (PubMed id 15543157)1, 2, 9 Ohren J.F.... Hasemann C.A. (Nat. Struct. Mol. Biol. 2004)
    5. Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5. (PubMed id 9465908)1, 3, 9 Rampoldi L....Danieli G.A. (Cytogenet. Cell Genet. 1997)
    6. Investigation of gene dosage imbalances in patients with Noonan syndrome using multiplex ligation-dependent probe amplification analysis. (PubMed id 20302979)1, 4, 9 NystrAPm A.M....Bondeson M.L. (Eur J Med Genet 2010)
    7. Mutation and phenotypic spectrum in patients with cardio-facio- cutaneous and Costello syndrome. (PubMed id 18042262)1, 2, 9 Schulz A.L.... Zenker M. (Clin. Genet. 2008)
    8. Cognitive profile of disorders associated with dysregulation of the RAS/MAPK signaling cascade. (PubMed id 19133693)1, 4, 9 Cesarini L....Zampino G. (Am. J. Med. Genet. A 2009)
    9. Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum. (PubMed id 19206169)1, 4, 9 Sarkozy A.... Tartaglia M. (Hum. Mutat. 2009)
    10. Germline mutations in genes within the MAPK pathway cause cardio- facio-cutaneous syndrome. (PubMed id 16439621)1, 2, 9 Rodriguez-Viciana P.... Rauen K.A. (Science 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5604 HGNC: 6840 AceView: MAP2K1 Ensembl:ENSG00000169032 euGenes: HUgn5604
    ECgene: MAP2K1 Kegg: 5604 H-InvDB: MAP2K1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAP2K1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP2K1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=MAP2K1[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAP2K1 gene:
    Search GeneIP for patents involving MAP2K1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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