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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MAP2 Gene

protein-coding GIFtS: 61
GCID: GC02P210252

microtubule-associated protein 2

Explore 86 diseases affiliated with
MAP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Microtubule-Associated Protein 2¹ ²
MAP2A¹ ²
MAP2B¹ ²
MAP2C¹ ²
MAP-2² ³

External Ids:	HGNC: 6839¹	Entrez Gene: 4133²	Ensembl: ENSG00000078018⁷	OMIM: 157130⁵	UniProtKB: P11137³

Export aliases for MAP2 gene to outside databases

Previous GC identifers: GC02P208719 GC02P209169 GC02P210491 GC02P210646 GC02P210114 GC02P209997 GC02P202133

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAP2:

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are

thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar

genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in

determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants

encoding distinct isoforms have been described. (provided by RefSeq, Jan 2010)

UniProtKB/Swiss-Prot: MAP2_HUMAN, P11137

Function: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They

also seem to have a stiffening effect on microtubules

Gene Wiki entry for MAP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MAP2 gene promoter:
AP-1 MyoD C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAP2 promoter sequence

Search SABiosciences Chromatin IP Primers for MAP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q34-q35 Ensembl cytogenetic band: 2q34 HGNC cytogenetic band: 2q34-q35

MAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P210252: view genomic region (about GC identifiers)

Start:	210,288,771 bp from pter	End:	210,598,842 bp from pter
Size:	310,072 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MAP2_HUMAN, P11137 (See protein sequence)

Recommended Name: Microtubule-associated protein 2

Size: 1827 amino acids; 199526 Da

Subcellular location: Cytoplasm, cytoskeleton (Probable)

Secondary accessions: Q17S04 Q8IUX2 Q99975 Q99976

Alternative splicing: 4 isoforms: P11137-1 P11137-2 P11137-3 P11137-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP2: NX_P11137

Post-translational modifications:

Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2),

causing detachment from microtubules, and their disassembly (By similarity). MAP2A/c is phosphorylated. Isoform MAP2c

is phosphorylated by FYN at Tyr-67¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P11137

MAP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001034627.1 NP_002365.3 NP_114033.2 NP_114035.2

ENSEMBL proteins:

ENSP00000199940 ENSP00000376031 ENSP00000353508 ENSP00000355290 ENSP00000409969

ENSP00000376032 ENSP00000392164 ENSP00000388824

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): MAP2 OriGene Protein Over-expression Lysate (see all 2): MAP2 OriGene Custom Protein Services for MAP2
	GenScript Custom Purified and Recombinant Proteins Services for MAP2
	Novus Biologicals MAP2 Protein Novus Biologicals MAP2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MAP2

Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	IEA	--
GO:0005874	microtubule	IEA	--
GO:0005875	microtubule associated complex	TAS	9588626
GO:0019718	rough microsome	--	--

MAP2 for ontologies About GeneDecksing

MAP2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP2
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for MAP2
	OriGene Antibodies (see all 3): MAP2 OriGene Custom Antibody Services for MAP2
	GenScript Superior Antibodies for MAP2
	Novus Biologicals MAP2 Antibodies
	Abcam antibodies for MAP2
	Uscn Antibodies for MAP2
	ThermoFisher Antibody for MAP2

Assay Products for MAP2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MAP2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MAP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MAP2 for domains About GeneDecksing

2 InterPro domains/families:

IPR001084 Tau/MAP_tubulin-bd_rpt

IPR013588 MAP2_projctn

Graphical View of Domain Structure for InterPro Entry P11137

ProtoNet protein and cluster: P11137

2 Blocks protein families:

IPB001084 Tubulin-binding Tau protein

IPB013588 MAP2/Tau projection

UniProtKB/Swiss-Prot: MAP2_HUMAN, P11137

Similarity: Contains 3 Tau/MAP repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MAP2_HUMAN, P11137

Function: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They

also seem to have a stiffening effect on microtubules

Genatlas biochemistry entry for MAP2:

microtubule (beta) associated protein 2,expressed in the cytoplasm of neural tissue and predominantly nuclear in germ

cells,with an alternatively spliced isoform expressing exon 13 (MAP2+13),expressed in fetal oligodendrocytes during

process extension and myelination,minimally expressed in normal mature CNS,expressed again in generating

oligodendrocytes in multiple slcerosis lesions

miRNA Products:		OriGene 3'-UTR Clone (see all 4): MAP2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP2
		8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP2 (see all 61):
		hsa-miR-21* hsa-miR-361-5p hsa-miR-429 hsa-miR-4272 hsa-miR-374a hsa-miR-3138 hsa-miR-488 hsa-miR-507

		SwitchGear 3'UTR luciferase reporter plasmid: MAP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP2 (see all 7) OriGene shRNA RFP: MAP2 OriGene siRNA: MAP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MAP2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP2 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP2 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): MAP2 (NM_031847)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MAP2
		Search LifeMap BioReagents cell lines for MAP2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002162	dystroglycan binding	IPI	18341635
GO:0005198	structural molecule activity	NAS	9588626
GO:0005515	protein binding	IPI	--
GO:0005516	calmodulin binding	IEA	--
GO:0015631	tubulin binding	IEA	--

MAP2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for MAP2: Map2^tm1Noh Map2^tm1Zhku
     4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Map2):

behavior/neurological

growth/size

mortality/aging

nervous system

MAP2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Neuroscience

Neuroscience

1.00

Selected targets of GCR-alpha

Selected targets of GCR-alpha

1.00

Selected targets of CREB1

Selected targets of CREB1

1.00

SIDS Susceptibility Pathways

SIDS Susceptibility Pathways

1.00

LKB1 signaling events

LKB1 signaling events

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for MAP2

	Selected targets of CREB1
	Selected targets of GCR-alpha
	Cytoplasmic microtubules

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MAP2

JNK Pathway

1 Cell Signaling Technology (CST) Pathway for MAP2

Neuroscience

3 BioSystems Pathways for MAP2

	SIDS Susceptibility Pathways
	MAPK Cascade
	LKB1 signaling events

1 PharmGKB Pathway for MAP2

Taxane Pathway, Pharmacokinetics

MAP2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MAP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/37 Interacting proteins for MAP2 (P11137^{1, 2, 3} ENSP00000353508⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 37)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRB2	P62993²^,³, ENSP00000339007⁴	MINT-8030505 MINT-50654 MINT-8030490 MINT-50655 MINT-50657 MINT-50658 MINT-50656 MINT-8030475 I2D: score=2 STRING: ENSP00000339007
FYN	P06241²^,³, ENSP00000357656⁴	MINT-50652 MINT-50653 I2D: score=2 STRING: ENSP00000357656
CBFB	Q13951¹^,³	EBI-2682460,EBI-718750 I2D: score=1
DLG4	P78352³, ENSP00000293813⁴	I2D: score=1 STRING: ENSP00000293813
GRIN1	Q05586³, ENSP00000360616⁴	I2D: score=1 STRING: ENSP00000360616

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001578	microtubule bundle formation	IEA	--
GO:0007409	axonogenesis	IEA	--
GO:0016358	dendrite development	--	--
GO:0018107	peptidyl-threonine phosphorylation	IEA	--
GO:0021954	central nervous system neuron development	IEP	--

MAP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MAP2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MAP2

1 DrugBank Compound for MAP2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Estramustine	Estramustin Sodium Phosphate (see all 4)	2998-57-4	target	antagonist	6364362 1599956 2125244 1647395 1908244 2679799

10/79 Novoseek chemical compound relationships for MAP2 gene (see all 79) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
map4	84.7	27	12732198 (4), 10542369 (3), 8631898 (3), 1309698 (3) (see all 16)
nmda	43.9	36	11423088 (5), 16904106 (5), 2169265 (4), 8207442 (3) (see all 15)
estramustine phosphate	42.9	24	9042950 (4), 1599956 (4), 2125244 (4)
phosphocellulose	42.3	1	15066174 (1)
retinoic acid	42	6	20074641 (2), 7861133 (1), 1997209 (1), 10802051 (1) (see all 5)
estramustine	41.5	9	9042950 (4), 1599956 (1), 1647395 (1)
glutamate	39	27	9332733 (3), 10582618 (3), 9776381 (2), 8789950 (2) (see all 16)
paclitaxel	36.8	15	7591286 (6), 10963366 (2), 8819014 (1), 1338311 (1) (see all 7)
nocodazole	36	4	1791975 (2), 16145685 (1), 8006079 (1)
cerebrolysin	34.6	2	15347036 (1), 8841974 (1)

Search CenterWatch for drugs/clinical trials and news about MAP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MAP2 gene (5 alternative transcripts):

NM_001039538.1 NM_002374.3 NM_031845.2 NM_031847.2 NM_031846.2

Unigene Cluster for MAP2:

Microtubule-associated protein 2

Hs.368281 [show with all ESTs]

Unigene Representative Sequence: NM_002374

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000199940 ENST00000392193 ENST00000360351(uc002vdc.1 uc002vdd.1 uc002vde.1 uc002vdf.1 uc002vdg.1 uc002vdi.1)

ENST00000361559 ENST00000445941 ENST00000392194(uc002vdh.1) ENST00000447185

ENST00000452717 ENST00000471619 ENST00000482864 ENST00000461253 ENST00000481649

ENST00000475600 ENST00000464007 ENST00000478233 ENST00000473543

miRNA Products:		OriGene 3'-UTR Clone (see all 4): MAP2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP2
		8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP2 (see all 61):
		hsa-miR-21* hsa-miR-361-5p hsa-miR-429 hsa-miR-4272 hsa-miR-374a hsa-miR-3138 hsa-miR-488 hsa-miR-507

		SwitchGear 3'UTR luciferase reporter plasmid: MAP2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP2 (see all 7) OriGene shRNA RFP: MAP2 OriGene siRNA: MAP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP2 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP2 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): MAP2 (NM_031847)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP2

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP2

Additional cDNA sequence:

AB209330.1 AF088065.1 AK055674.1 AK056148.1 AK291446.1 AK307603.1 AL833567.1 BC027583.1

BC038857.1 BC066648.1 BC110423.1 BC117123.1 BC143245.1 M25668.1 S76756.1 U01828.1

U89329.1 U89330.1

21 DOTS entries:

DT.447934 DT.97843797 DT.100823230 DT.100027558 DT.100027557 DT.91707856 DT.100823225 DT.411466

DT.101981734 DT.95299768 DT.100027555 DT.99971548 DT.120944529 DT.120944532 DT.86850226 DT.91647992

DT.100027556 DT.75163039 DT.91707853 DT.95305705 DT.95326146

24/233 AceView cDNA sequences (see all 233):

BX510234 AA693467 AL134015 AL530403 S76756 AA211402 CA412425 AI805992

AA348720 AA259152 AA283724 AW016476 BU072579 BM762431 CB149848 AA331387

BX111044 BM925644 BU634096 AV718243 BM663357 BU538528 AI697593 BX477894

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for MAP2 (see all 16) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13	^	14a	·	14b	·	14c	·	14d	^	15	^	16	^	17	^	18	^	19a	·	19b	^	20a	·
SP1:			-				-		-				-								-		-								-		-		-		-		-		-						-
SP2:													-								-		-																						-		-
SP3:																					-		-								-		-		-		-		-		-						-
SP4:																					-		-								-														-		-
SP5:													-								-		-								-		-		-		-		-		-				-		-

ExUns:	20b	·	20c	·	20d	^	21	^	22	^	23a	·	23b	·	23c	^	24	^	25a	·	25b	·	25c	·	25d
SP1:							-
SP2:							-		-						-
SP3:							-		-
SP4:							-		-
SP5:							-		-

ECgene alternative splicing isoforms for MAP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MAP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTTCAATC

About this image

MAP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Eye

Retina

Eye

Spinal Cord

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

Neural stem cells (Fetal Stem / Progenitor Cell)

Spinal Cord

GABA neuron-like cells (Generation of motor ...)

Brain

Motor neuron-like cells (Differentiation of ...)

Human kidney epithelial cell spheroids (Kidney spheroids for...)

See MAP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAP2

SOURCE GeneReport for Unigene cluster: Hs.368281

SABiosciences Expression via Pathway-Focused PCR Arrays including MAP2:

Neurogenesis in human mouse rat

Terminal Differentiation Markers in human mouse rat

Alzheimer's Disease in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MAP2 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MAP2¹	microtubule-associated protein 2	68.16(n) 63.87(a)		424001 XM_421857.2 XP_421857.2
lizard (Anolis carolinensis)	Reptilia	MAP2⁶	--	57(a)	1 ↔ 1	1(113000007-113117579)
African clawed frog (Xenopus laevis)	Amphibia	a730034c02-prov²	microtubule-associated protein 2	77.43(n)		BC046689.1
zebrafish (Danio rerio)	Actinopterygii	map2¹	microtubule-associated protein 2	51.43(n) 44.2(a)		450004 XM_002663408.2 XP_002663454.2
fruit fly (Drosophila melanogaster)	Insecta	tau⁶	tau	24(a)	1 → many	3R(23466365-23482718)

ENSEMBL Gene Tree for MAP2 (if available)
TreeFam Gene Tree for MAP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MAP2 gene

MAPT² MAP4²

MAP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35411820^1,2	C	--	210286856(+)	`GGAAA-/AAAC AAACA`	1	--	us2k¹		0	--	--	--	--
rs145745246^1,2		--	210286856(+)	`GGAAA-/AAAC AAACA`	1	--	us2k¹		0	--	--	--	--
rs79246906^1,2	C,	--	210286906(+)	`ACACTG/ATACTT`	1	--	us2k¹		2		NA	122
rs72995629^1,2	C,	--	210287075(+)	`GGTGTA/GAGCCA`	1	--	us2k¹		0	--	--	--	--
rs141263173^1,2		--	210287146(+)	`AATGTC/TAGCTG`	1	--	us2k¹		0	--	--	--	--
rs73065162^1,2	C,	--	210287237(+)	`TCAGTA/GAGGCC`	1	--	us2k¹		2		WA	120
rs150291054^1,2		--	210287243(+)	`AGGCCA/GTCTTC`	1	--	us2k¹		0	--	--	--	--
rs78226633^1,2	F,	--	210287320(+)	`TGCAAG/ACGTCA`	1	--	us2k¹		1		WA	118
rs75904693^1,2	C,	--	210287334(+)	`GCACAT/CGGTAT`	1	--	us2k¹		2		NA	122
rs137926627^1,2		--	210287387(+)	`CTGGGA/GAGGGC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MAP2 (210288771 - 210538771 bp, first 250kb of MAP2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for MAP2
3 CNVs: 98124 90245 90246
Human Gene Mutation Database (HGMD): MAP2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP2

DNA2.0 Custom Variant and Variant Library Synthesis for MAP2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MAP2 for disorders           About GeneDecksing

OMIM gene information: 157130    OMIM disorders: --

20/86 diseases for MAP2 (see all 86):    About MalaCards

human monocytic ehrlichiosis spinal cord injury subependymal giant cell astrocytoma striatonigral degeneration

dysembryoplastic neuroepithelial tumor gliomatosis cerebri transient cerebral ischemia olivopontocerebellar atrophy

supranuclear palsy progressive supranuclear palsy amyotrophic lateral sclerosis temporal lobe epilepsy

ehrlichiosis central neurocytoma multiple system atrophy cerebral artery occlusion

major depressive disorder lateral sclerosis neuronal migration disorders tuberous sclerosis

5 diseases from the University of Copenhagen DISEASES database for MAP2:

Alzheimer's disease Brain disease Vascular disease Toxic encephalopathy

Cancer

10/78 Novoseek disease relationships for MAP2 gene (see all 78) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
paired helical filament	79.8	15	8955102 (3), 1373018 (2), 1707726 (1), 10527895 (1) (see all 10)
neurofibrillary tangles	67.2	7	1707726 (1), 8954102 (1), 16104002 (1), 1335088 (1) (see all 6)
neuroepithelial tumors	58.8	5	11589429 (2), 15146346 (1), 12670051 (1)
alzheimers disease	58.6	13	7891887 (2), 8954102 (2), 8955102 (1), 10781592 (1) (see all 11)
neuropil threads	57.4	1	9786247 (1)
neurodegenerative diseases	52.5	1	10335552 (1)
neurodegeneration	51	6	19101630 (1), 9974143 (1), 2013758 (1), 8051544 (1) (see all 5)
cerebral ischemia	48.3	2	17199994 (1), 1722131 (1)
gliosis	47.9	7	16400226 (2), 12605891 (1), 19587288 (1), 17562830 (1) (see all 6)
senile plaques	46.1	2	1335088 (1), 9930899 (1)

Human Genome Epidemiology (HuGE) Navigator: MAP2 (7 documents)

Export disorders for MAP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MAP2 gene, integrated from 9 sources (see all 647):
(articles sorted by number of sources associating them with MAP2)

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Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms. (PubMed id 7479905)^{1, 3, 9} Kalcheva N....Shafit-Zagardo B. (1995)
Fyn phosphorylates human MAP-2c on tyrosine 67. (PubMed id 15536091)^{1, 2, 9} Zamora-Leon S.P....Shafit-Zagardo B. (2005)
Characterization of the transcripts encoding two isoforms of human microtubule-associated protein-2 (MAP-2). (PubMed id 8294038)^{1, 2, 9} Albala J.S.... Shafit-Zagardo B. (1993)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Sequence of a human MAP-2 region sharing epitopes with Alzheimer neurofibrillary tangles. (PubMed id 2481044)^{1, 2} Dammerman M.... Shafit-Zagardo B. (1989)
Partial sequence of MAP2 in the region of a shared epitope with Alzheimer neurofibrillary tangles. (PubMed id 2455776)^{1, 2} Kosik K.S.... Neve R.L. (1988)
Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2. (PubMed id 3103857)^{1, 3} Neve R.L....Donlon T.A. (1986)
Involvement of microtubule-associated protein 2 (MAP2) in oral cancer cell motility: a novel biological function of MAP2 in non-neuronal cells. (PubMed id 18073143)^{1, 9} Liu S.Y....Chen J.Y. (2008)
Regulated association of microtubule-associated protein 2 (MAP2) with Src and Grb2: evidence for MAP2 as a scaffolding protein. (PubMed id 10781592)^{1, 9} Lim R.W. and Halpain S. (2000)
Oncogenic BRAFV600E induces expression of neuronal di fferentiation marker MAP2 in melanoma cells by promoter demethylation and down- regulation of transcription repressor HES1. (PubMed id 19880519)^{1, 9} Maddodi N....Setaluri V. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4133	HGNC: 6839	AceView: MAP2	Ensembl:ENSG00000078018	euGenes: HUgn4133
ECgene: MAP2	H-InvDB: MAP2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MAP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MAP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MAP2 gene:
Search GeneIP for patents involving MAP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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microtubule-associated protein 2

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MAP2 Gene

microtubule-associated protein 2

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