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MAP2 Gene

protein-coding   GIFtS: 63
GCID: GC02P210252

Microtubule-Associated Protein 2

  See MAP2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microtubule-Associated Protein 21 2
MAP-22 3
MAP2A2
MAP2B2
MAP2C2

External Ids:    HGNC: 68391   Entrez Gene: 41332   Ensembl: ENSG000000780187   OMIM: 1571305   UniProtKB: P111373   

Export aliases for MAP2 gene to outside databases

Previous GC identifers: GC02P208719 GC02P209169 GC02P210491 GC02P210646 GC02P210114 GC02P209997 GC02P202133


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP2 Gene:
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family
are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of
similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites,
implicating a role in determining and stabilizing dentritic shape during neuron development. A number of
alternatively spliced variants encoding distinct isoforms have been described. (provided by RefSeq, Jan 2010)

GeneCards Summary for MAP2 Gene:
MAP2 (microtubule-associated protein 2) is a protein-coding gene. Diseases associated with MAP2 include ehrlichiosis, and human monocytic ehrlichiosis. GO annotations related to this gene include microtubule binding and structural molecule activity. An important paralog of this gene is MAPT.

UniProtKB/Swiss-Prot: MTAP2_HUMAN, P11137
Function: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization.
They also seem to have a stiffening effect on microtubules

Gene Wiki entry for MAP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP2 gene promoter:
         AP-1   MyoD   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP2 promoter sequence
   Search Chromatin IP Primers for MAP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q34-q35   Ensembl cytogenetic band:  2q34   HGNC cytogenetic band: 2q34-q35

MAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P210252:  view genomic region     (about GC identifiers)

Start:
210,288,771 bp from pter      End:
210,598,842 bp from pter
Size:
310,072 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MTAP2_HUMAN, P11137 (See protein sequence)
Recommended Name: Microtubule-associated protein 2  
Size: 1827 amino acids; 199526 Da
Secondary accessions: Q17S04 Q8IUX2 Q99975 Q99976
Alternative splicing: 4 isoforms:  P11137-1   P11137-2   P11137-3   P11137-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP2: NX_P11137

Explore proteomics data for MAP2 at MOPED

Post-translational modifications: 

  • Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or
    MARK2), causing detachment from microtubules, and their disassembly (By similarity). MAP2A/c is phosphorylated.
    Isoform MAP2c is phosphorylated by FYN at Tyr-671
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MAP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001034627.1  NP_002365.3  NP_114033.2  NP_114035.2  

    ENSEMBL proteins: 
     ENSP00000199940   ENSP00000376031   ENSP00000353508   ENSP00000355290   ENSP00000409969  
     ENSP00000376032   ENSP00000392164   ENSP00000388824  

    MAP2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Proteins for MAP2
    OriGene Protein Over-expression Lysate for MAP2
    OriGene MassSpec for MAP2
    OriGene Custom Protein Services for MAP2
    GenScript Custom Purified and Recombinant Proteins Services for MAP2
    Novus Biologicals MAP2 Protein
    Novus Biologicals MAP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAP2

     
    Search eBioscience for Proteins for MAP2 

    MAP2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for MAP2 
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    Abcam antibodies for MAP2
    Cloud-Clone Corp. Antibodies for MAP2
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    LSBio Antibodies in human, mouse, rat for MAP2

    MAP2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAP2
    Cloud-Clone Corp. CLIAs for MAP2
    Search eBioscience for ELISAs for MAP2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AKAP: A-kinase anchor proteins

    3 InterPro protein domains:
     IPR027324 MAP2/MAP4/Tau
     IPR001084 MAP_tubulin-bd_rpt
     IPR013588 MAP2_projctn

    Graphical View of Domain Structure for InterPro Entry P11137

    ProtoNet protein and cluster: P11137

    2 Blocks protein domains:
    IPB001084 Tubulin-binding Tau protein
    IPB013588 MAP2/Tau projection


    UniProtKB/Swiss-Prot: MTAP2_HUMAN, P11137
    Similarity: Contains 3 Tau/MAP repeats


    Find genes that share domains with MAP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTAP2_HUMAN, P11137
    Function: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization.
    They also seem to have a stiffening effect on microtubules

         Genatlas biochemistry entry for MAP2:
    microtubule (beta) associated protein 2,expressed in the cytoplasm of neural tissue and predominantly nuclear in
    germ cells,with an alternatively spliced isoform expressing exon 13 (MAP2+13),expressed in fetal oligodendrocytes
    during process extension and myelination,minimally expressed in normal mature CNS,expressed again in generating
    oligodendrocytes in multiple slcerosis lesions

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002162dystroglycan binding IPI18341635
    GO:0005198structural molecule activity NAS9588626
    GO:0005515protein binding IPI--
    GO:0005516calmodulin binding IEA--
    GO:0008017microtubule binding IEA--
         
    Find genes that share ontologies with MAP2           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Map2):
     behavior/neurological  endocrine/exocrine gland  growth/size/body  mortality/aging  nervous system 
     reproductive system 

    Find genes that share phenotypes with MAP2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MAP2: Map2tm1Noh Map2tm1Zhku

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAP2:
    hsa-mir-335-5p (MIRT019140)

    Block miRNA regulation of human, mouse, rat MAP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP2 (see all 61):
    hsa-miR-21* hsa-miR-361-5p hsa-miR-429 hsa-miR-4272 hsa-miR-374a hsa-miR-3138 hsa-miR-488 hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidMAP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAP2
    Predesigned siRNA for gene silencing in human, mouse, rat MAP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAP2

    Clone
    Products:
         
    OriGene clones in human, mouse for MAP2 (see all 23)
    OriGene ORF clones in mouse, rat for MAP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MAP2 (NM_031847)
    Sino Biological Human cDNA Clone for MAP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP2

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA4-12753 VA6-11599) for MAP2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MTAP2_HUMAN, P11137: Cytoplasm, cytoskeleton (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    nucleus3
    vacuole3
    cytosol2
    lysosome2
    mitochondrion2
    endoplasmic reticulum1
    extracellular1
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule IEA--
    GO:0005875microtubule associated complex TAS9588626
    GO:0034399nuclear periphery IEA--

    Find genes that share ontologies with MAP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP2 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1TGF-Beta Pathway
    JNK Pathway0.51
    2G protein signaling Ras family GTPases in kinase cascades scheme
    MAPK Cascade0.44
    3Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    4Irinotecan Pathway, Pharmacokinetics
    Taxane Pathway, Pharmacokinetics0.30
    5SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways


    Find genes that share SuperPaths with MAP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MAP2
        JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for MAP2
        Neuroscience

    3 BioSystems Pathways for MAP2
        SIDS Susceptibility Pathways
    MAPK Cascade
    LKB1 signaling events


    1 PharmGKB Pathway for MAP2
        Taxane Pathway, Pharmacokinetics

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP2: 
              Neurogenesis in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Alzheimer's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAP2 (P111371, 2, 3 ENSP000003535084) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629932, 3, ENSP000003390074MINT-8030505 MINT-50654 MINT-8030490 MINT-50655 MINT-50657 MINT-50658 MINT-50656 MINT-8030475 I2D: score=2 STRING: ENSP00000339007
    FYNP062412, 3, ENSP000003576564MINT-50652 MINT-50653 I2D: score=2 STRING: ENSP00000357656
    CBFBQ139511, 3EBI-2682460,EBI-718750 I2D: score=1 
    CAMK2DQ135573, ENSP000003397404I2D: score=1 STRING: ENSP00000339740
    GRIN1Q055863, ENSP000003606164I2D: score=1 STRING: ENSP00000360616
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001578microtubule bundle formation IEA--
    GO:0007409axonogenesis IEA--
    GO:0016358dendrite development ----
    GO:0018107peptidyl-threonine phosphorylation IEA--
    GO:0021954central nervous system neuron development IEP--

    Find genes that share ontologies with MAP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAP2 (MTAP2)

    3 DrugBank Compounds for MAP2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    EstramustineEstramustin Sodium Phosphate (see all 4)2998-57-4targetantagonist6364362 1599956 2125244 1647395 1908244 2679799
    DocetaxelDocetaxel anhydrous (see all 4)114977-28-5target--18068131
    Paclitaxel7-epi-Paclitaxel (see all 8)33069-62-4target--18068131

    Selected Novoseek inferred chemical compound relationships for MAP2 gene (see all 79)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    map4 84.7 27 12732198 (4), 10542369 (3), 8631898 (3), 1309698 (3) (see all 16)
    nmda 43.9 36 11423088 (5), 16904106 (5), 2169265 (4), 8207442 (3) (see all 15)
    estramustine phosphate 42.9 24 9042950 (4), 1599956 (4), 2125244 (4)
    phosphocellulose 42.3 1 15066174 (1)
    retinoic acid 42 6 20074641 (2), 7861133 (1), 1997209 (1), 10802051 (1) (see all 5)
    estramustine 41.5 9 9042950 (4), 1599956 (1), 1647395 (1)
    glutamate 39 27 9332733 (3), 10582618 (3), 9776381 (2), 8789950 (2) (see all 16)
    paclitaxel 36.8 15 7591286 (6), 10963366 (2), 8819014 (1), 1338311 (1) (see all 7)
    nocodazole 36 4 1791975 (2), 16145685 (1), 8006079 (1)
    cerebrolysin 34.6 2 15347036 (1), 8841974 (1)



    Find genes that share compounds with MAP2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAP2 gene (5 alternative transcripts): 
    NM_001039538.1  NM_002374.3  NM_031845.2  NM_031847.2  NM_031846.2  

    Unigene Cluster for MAP2:

    Microtubule-associated protein 2
    Hs.368281  [show with all ESTs]
    Unigene Representative Sequence: NM_002374
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000199940 ENST00000392193 ENST00000360351(uc002vdc.1 uc002vdd.1 uc002vde.1 uc002vdf.1 uc002vdg.1 uc002vdi.1)
    ENST00000361559 ENST00000445941 ENST00000392194(uc002vdh.1) ENST00000447185
    ENST00000452717 ENST00000471619 ENST00000482864 ENST00000461253 ENST00000481649
    ENST00000475600 ENST00000464007 ENST00000478233 ENST00000473543
    miRNA
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    Block miRNA regulation of human, mouse, rat MAP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP2 (see all 61):
    hsa-miR-21* hsa-miR-361-5p hsa-miR-429 hsa-miR-4272 hsa-miR-374a hsa-miR-3138 hsa-miR-488 hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidMAP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MAP2
    Clone
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    OriGene ORF clones in mouse, rat for MAP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MAP2 (NM_031847)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP2
    Primer
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    OriGene qPCR primer pairs and template standards for MAP2
    OriGene qSTAR qPCR primer pairs in human, mouse for MAP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MAP2
      QuantiTect SYBR Green Assays in human, mouse, rat MAP2
      QuantiFast Probe-based Assays in human, mouse, rat MAP2
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA4-12753 VA6-11599) for MAP2 

    Additional mRNA sequence: 

    AB209330.1 AF088065.1 AK055674.1 AK056148.1 AK291446.1 AK307603.1 AL833567.1 BC027583.1 
    BC038857.1 BC066648.1 BC110423.1 BC117123.1 BC143245.1 M25668.1 S76756.1 U01828.1 
    U89329.1 U89330.1 

    21 DOTS entries:

    DT.447934  DT.97843797  DT.100823230  DT.100027558  DT.100027557  DT.91707856  DT.100823225  DT.411466 
    DT.101981734  DT.95299768  DT.100027555  DT.99971548  DT.120944529  DT.120944532  DT.86850226  DT.91647992 
    DT.100027556  DT.75163039  DT.91707853  DT.95305705  DT.95326146 

    Selected AceView cDNA sequences (see all 233):

    BX510234 AA693467 AL134015 AL530403 AA348720 CA412425 AA211402 S76756 
    AI805992 AA259152 AA283724 AW016476 BU072579 CB149848 BM762431 AA331387 
    BX111044 BU634096 BM925644 BM663357 AV718243 BU538528 AI697593 BX477894 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAP2 (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
    SP1:        -           -     -           -                       -     -                       -     -     -     -     -     -                 -               
    SP2:                                      -                       -     -                                                                 -     -               
    SP3:                                                              -     -                       -     -     -     -     -     -                 -               
    SP4:                                                              -     -                       -                                         -     -               
    SP5:                                      -                       -     -                       -     -     -     -     -     -           -     -               

    ExUns: 20b · 20c · 20d ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25a · 25b · 25c · 25d
    SP1:                    -                                                         
    SP2:                    -     -                 -                                 
    SP3:                    -     -                                                   
    SP4:                    -     -                                                   
    SP5:                    -     -                                                   


    ECgene alternative splicing isoforms for MAP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTCAATC
    MAP2 Expression
    About this image


    MAP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 18 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
             Neural progenitor cells
     
     Neurons
             Motor neuron-like cells
     
     Dopaminergic Neurons (Nervous System)    fully expand to see all 4 entries
             Dopaminergic-like neurons
     
     Spinal Cord (Nervous System)    fully expand to see all 5 entries
             Neural stem cells
             Motor neuron-like cells
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
    MAP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368281
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP2: 
              Neurogenesis in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Alzheimer's Disease in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MAP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map21 , 5 microtubule-associated protein 21, 5 86.8(n)1
    92.72(a)1
      1 (33.49 cM)5
    177561  NM_001039934.11  NP_001035023.11 
     661752735 
    chicken
    (Gallus gallus)
    Aves MAP21 microtubule-associated protein 2 68.5(n)
    64.69(a)
      424001  XM_004942440.1  XP_004942497.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAP26
    microtubule-associated protein 2
    58(a)
    1 ↔ 1
    1(113000007-113122231)
    African clawed frog
    (Xenopus laevis)
    Amphibia a730034c02-prov2 microtubule-associated protein 2 77.43(n)    BC046689.1 
    zebrafish
    (Danio rerio)
    Actinopterygii map26
    microtubule-associated protein 2
    32(a)
    1 ↔ 1
    9(39935697-40045681) ENSDARG00000055052
    fruit fly
    (Drosophila melanogaster)
    Insecta tau6
    tau
    24(a)
    1 → many
    3R(23466365-23482718)
    worm
    (Caenorhabditis elegans)
    Secernentea ptl-16
    Protein PTL-1, isoform b
    14(a)
    1 → many
    III(763810-771390) WBGene00004212


    ENSEMBL Gene Tree for MAP2 (if available)
    TreeFam Gene Tree for MAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP2 gene
    MAPT2  MAP42  

    Find genes that share paralogs with MAP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP2 (see all 5709)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360154
    A colorectal cancer sample4--see VAR_0360152 P L mis40--------
    VAR_0360144
    A colorectal cancer sample4--see VAR_0360142 E D mis40--------
    rs1487581701,2
    Cuntested1210561708(+) AAATTC/G/TATTTT 5 F int1 syn10--------
    rs788019141,2
    C--209683677(+) GAACA-/TAAAATA 1 -- int10--------
    rs354118201,2
    C--210286856(+) GGAAA-/AAAC  
            
    AAACA
    1 -- us2k10--------
    rs1457452461,2
    C--210286856(+) GGAAA-/AAAC  
            
    AAACA
    1 -- us2k10--------
    rs792469061,2
    C,F--210286906(+) ACACTG/ATACTT 1 -- us2k12Minor allele frequency- A:0.05NA 122
    rs729956291,2
    C--210287075(+) GGTGTA/GAGCCA 1 -- us2k10--------
    rs1412631731,2
    --210287146(+) AATGTC/TAGCTG 1 -- us2k10--------
    rs730651621,2
    C,F--210287237(+) TCAGTA/GAGGCC 1 -- us2k12Minor allele frequency- G:0.13WA 120

    HapMap Linkage Disequilibrium report for MAP2 (210288771 - 210538771 bp, first 250kb of MAP2)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for MAP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678028CNV Deletion23128226
    esv2608148CNV Deletion19546169
    esv1055449CNV Insertion17803354
    nsv507065CNV Insertion20534489
    nsv3141CNV Insertion18451855
    nsv875765CNV Loss21882294
    nsv834518CNV Loss17160897
    nsv214706CNV Loss16902084
    nsv834519CNV Loss17160897

    Human Gene Mutation Database (HGMD): MAP2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP2
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 157130    OMIM disorders: --

    11 diseases for MAP2:    
    About MalaCards
    ehrlichiosis    human monocytic ehrlichiosis    pituicytoma    striatonigral degeneration
    gliomatosis cerebri    brain ischemia    central neurocytoma    olivopontocerebellar atrophy
    dysembryoplastic neuroepithelial tumor    subependymal giant cell astrocytoma    ischemia

    5 diseases from the University of Copenhagen DISEASES database for MAP2:
    Alzheimer's disease     Vascular disease     Brain disease     Toxic encephalopathy
    Cancer

    Find genes that share disorders with MAP2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for MAP2 gene (see all 78)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paired helical filament 79.8 15 8955102 (3), 1373018 (2), 1707726 (1), 10527895 (1) (see all 10)
    neurofibrillary tangles 67.2 7 1707726 (1), 8954102 (1), 16104002 (1), 1335088 (1) (see all 6)
    neuroepithelial tumors 58.8 5 11589429 (2), 15146346 (1), 12670051 (1)
    alzheimers disease 58.6 13 7891887 (2), 8954102 (2), 8955102 (1), 10781592 (1) (see all 11)
    neuropil threads 57.4 1 9786247 (1)
    neurodegenerative diseases 52.5 1 10335552 (1)
    neurodegeneration 51 6 19101630 (1), 9974143 (1), 2013758 (1), 8051544 (1) (see all 5)
    cerebral ischemia 48.3 2 17199994 (1), 1722131 (1)
    gliosis 47.9 7 16400226 (2), 12605891 (1), 19587288 (1), 17562830 (1) (see all 6)
    senile plaques 46.1 2 1335088 (1), 9930899 (1)

    Genetic Association Database (GAD): MAP2
    Human Genome Epidemiology (HuGE) Navigator: MAP2 (7 documents)

    Export disorders for MAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP2 gene, integrated from 10 sources (see all 656):
    (articles sorted by number of sources associating them with MAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms. (PubMed id 7479905)1, 3, 9 Kalcheva N....Shafit-Zagardo B. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    2. Fyn phosphorylates human MAP-2c on tyrosine 67. (PubMed id 15536091)1, 2, 9 Zamora-Leon S.P.... Shafit-Zagardo B. (J. Biol. Chem. 2005)
    3. Characterization of the transcripts encoding two isoforms of human microtubule-associated protein-2 (MAP-2). (PubMed id 8294038)1, 2, 9 Albala J.S.... Shafit-Zagardo B. (Gene 1993)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. Sequence of a human MAP-2 region sharing epitopes with Alzheimer neurofibrillary tangles. (PubMed id 2481044)1, 2 Dammerman M.... Shafit-Zagardo B. (J. Neurosci. Res. 1989)
    8. Partial sequence of MAP2 in the region of a shared epitope with Alzheimer neurofibrillary tangles. (PubMed id 2455776)1, 2 Kosik K.S.... Neve R.L. (J. Neurochem. 1988)
    9. Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2. (PubMed id 3103857)1, 3 Neve R.L....Donlon T.A. (Brain Res. 1986)
    10. Involvement of microtubule-associated protein 2 (MAP2) in oral cancer cell motility: a novel biological function of MAP2 in non-neuronal cells. (PubMed id 18073143)1, 9 Liu S.Y....Chen J.Y. (Biochem. Biophys. Res. Commun. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4133 HGNC: 6839 AceView: MAP2 Ensembl:ENSG00000078018 euGenes: HUgn4133
    ECgene: MAP2 H-InvDB: MAP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAP2 gene:
    Search GeneIP for patents involving MAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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