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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP2 Gene

protein-coding   GIFtS: 64
GCID: GC02P210252

Microtubule-Associated Protein 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Microtubule-Associated Protein 21 2
MAP-22 3
MAP2A2
MAP2B2
MAP2C2

External Ids:    HGNC: 68391   Entrez Gene: 41332   Ensembl: ENSG000000780187   OMIM: 1571305   UniProtKB: P111373   

Export aliases for MAP2 gene to outside databases

Previous GC identifers: GC02P208719 GC02P209169 GC02P210491 GC02P210646 GC02P210114 GC02P209997 GC02P202133


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAP2 Gene:
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family
are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of
similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites,
implicating a role in determining and stabilizing dentritic shape during neuron development. A number of
alternatively spliced variants encoding distinct isoforms have been described. (provided by RefSeq, Jan 2010)

GeneCards Summary for MAP2 Gene: 
MAP2 (microtubule-associated protein 2) is a protein-coding gene. Diseases associated with MAP2 include ehrlichiosis, and human monocytic ehrlichiosis, and among its related super-pathways are MAPK Family Pathway and G-protein signaling Ras family GTPases in kinase cascades (scheme). GO annotations related to this gene include structural molecule activity and tubulin binding. An important paralog of this gene is MAPT.

UniProtKB/Swiss-Prot: MTAP2_HUMAN, P11137
Function: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization.
They also seem to have a stiffening effect on microtubules

Gene Wiki entry for MAP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP2 gene promoter:
         AP-1   MyoD   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q34-q35   Ensembl cytogenetic band:  2q34   HGNC cytogenetic band: 2q34-q35

MAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P210252:  view genomic region     (about GC identifiers)

Start:
210,288,771 bp from pter      End:
210,598,842 bp from pter
Size:
310,072 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MTAP2_HUMAN, P11137 (See protein sequence)
Recommended Name: Microtubule-associated protein 2  
Size: 1827 amino acids; 199526 Da
Subcellular location: Cytoplasm, cytoskeleton (Probable)
Secondary accessions: Q17S04 Q8IUX2 Q99975 Q99976
Alternative splicing: 4 isoforms:  P11137-1   P11137-2   P11137-3   P11137-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP2: NX_P11137

Explore proteomics data for MAP2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or
    MARK2), causing detachment from microtubules, and their disassembly (By similarity). MAP2A/c is phosphorylated.
    Isoform MAP2c is phosphorylated by FYN at Tyr-67
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P11137

  • MAP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAP2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001034627.1  NP_002365.3  NP_114033.2  NP_114035.2  

    ENSEMBL proteins: 
     ENSP00000199940   ENSP00000376031   ENSP00000353508   ENSP00000355290   ENSP00000409969  
     ENSP00000376032   ENSP00000392164   ENSP00000388824  

    Human Recombinant Protein Products for MAP2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for MAP2
    OriGene Protein Over-expression Lysate for MAP2
    OriGene MassSpec for MAP2 
    OriGene Custom Protein Services for MAP2
    GenScript Custom Purified and Recombinant Proteins Services for MAP2
    Novus Biologicals MAP2 Protein
    Novus Biologicals MAP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAP2 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule IEA--
    GO:0005875microtubule associated complex TAS9588626
    GO:0030425dendrite ----

    MAP2 for ontologies           About GeneDecksing



    MAP2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for MAP2 
    OriGene Antibodies for MAP2
    OriGene Custom Antibody Services for MAP2
    GenScript Superior Antibodies for MAP2
    Novus Biologicals MAP2 Antibodies
    Abcam antibodies for MAP2
    Cloud-Clone Corp. Antibodies for MAP2 
    ThermoFisher Antibody for MAP2
    LSBio Antibodies in human, mouse, rat for MAP2 

    Assay Products for MAP2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAP2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAP2 
    Cloud-Clone Corp. CLIAs for MAP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    AKAP: A-kinase anchor proteins

    3 InterPro protein domains:
     IPR027324 MAP2/MAP4/Tau
     IPR001084 Tau/MAP_tubulin-bd_rpt
     IPR013588 MAP2_projctn

    Graphical View of Domain Structure for InterPro Entry P11137

    ProtoNet protein and cluster: P11137

    2 Blocks protein domains:
    IPB001084 Tubulin-binding Tau protein
    IPB013588 MAP2/Tau projection


    UniProtKB/Swiss-Prot: MTAP2_HUMAN, P11137
    Similarity: Contains 3 Tau/MAP repeats


    MAP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MTAP2_HUMAN, P11137
    Function: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization.
    They also seem to have a stiffening effect on microtubules

         Genatlas biochemistry entry for MAP2:
    microtubule (beta) associated protein 2,expressed in the cytoplasm of neural tissue and predominantly nuclear in
    germ cells,with an alternatively spliced isoform expressing exon 13 (MAP2+13),expressed in fetal oligodendrocytes
    during process extension and myelination,minimally expressed in normal mature CNS,expressed again in generating
    oligodendrocytes in multiple slcerosis lesions

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002162dystroglycan binding IPI18341635
    GO:0005198structural molecule activity NAS9588626
    GO:0005515protein binding IPI--
    GO:0005516calmodulin binding IEA--
    GO:0008017microtubule binding IEA--
         
    MAP2 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Map2):
     behavior/neurological  growth/size  mortality/aging  nervous system 

    MAP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MAP2: Map2tm1Noh Map2tm1Zhku

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP2
    8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP2 (see all 61):
    hsa-miR-21* hsa-miR-361-5p hsa-miR-429 hsa-miR-4272 hsa-miR-374a hsa-miR-3138 hsa-miR-488 hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidMAP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAP2
    Sirion Biotech Customized adenovirus for overexpression of MAP2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MAP2 (see all 21)
    OriGene ORF clones in mouse, rat for MAP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MAP2 (NM_031847)
    Sino Biological Human cDNA Clone for MAP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MAP2
    Search LifeMap BioReagents cell lines for MAP2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAP2 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TGF-Beta Pathway
    JNK Pathway0.51
    2G-protein signaling Ras family GTPases in kinase cascades (scheme)
    MAPK Cascade0.44
    3Cytoskeleton remodeling Neurofilaments
    Cytoplasmic microtubules0.32
    4Irinotecan Pathway, Pharmacokinetics
    Taxane Pathway, Pharmacokinetics0.30
    5Selected targets of GCR-alpha
    Selected targets of GCR-alpha

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for MAP2
        Selected targets of CREB1
    Selected targets of GCR-alpha
    Cytoplasmic microtubules

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MAP2
        JNK Pathway

    1 Cell Signaling Technology (CST) Pathway for MAP2
        Neuroscience

    3 BioSystems Pathways for MAP2
        SIDS Susceptibility Pathways
    MAPK Cascade
    LKB1 signaling events


    1 PharmGKB Pathway for MAP2
        Taxane Pathway, Pharmacokinetics


    MAP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for MAP2 (P111371, 2, 3 ENSP000003535084) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629932, 3, ENSP000003390074MINT-8030505 MINT-50654 MINT-8030490 MINT-50655 MINT-50657 MINT-50658 MINT-50656 MINT-8030475 I2D: score=2 STRING: ENSP00000339007
    FYNP062412, 3, ENSP000003576564MINT-50652 MINT-50653 I2D: score=2 STRING: ENSP00000357656
    CBFBQ139511, 3EBI-2682460,EBI-718750 I2D: score=1 
    GRIN1Q055863, ENSP000003606164I2D: score=1 STRING: ENSP00000360616
    GRIN2BQ132243, ENSP000002795934I2D: score=1 STRING: ENSP00000279593
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001578microtubule bundle formation IEA--
    GO:0007409axonogenesis IEA--
    GO:0016358dendrite development ----
    GO:0018107peptidyl-threonine phosphorylation IEA--
    GO:0021954central nervous system neuron development IEP--

    MAP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP2 (MTAP2)

    3 DrugBank Compounds for MAP2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    EstramustineEstramustin Sodium Phosphate (see all 4)2998-57-4targetantagonist6364362 1599956 2125244 1647395 1908244 2679799
    DocetaxelDocetaxel anhydrous (see all 4)114977-28-5target--18068131
    Paclitaxel7-epi-Paclitaxel (see all 8)33069-62-4target--18068131

    10/79 Novoseek inferred chemical compound relationships for MAP2 gene (see all 79)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    map4 84.7 27 12732198 (4), 10542369 (3), 8631898 (3), 1309698 (3) (see all 16)
    nmda 43.9 36 11423088 (5), 16904106 (5), 2169265 (4), 8207442 (3) (see all 15)
    estramustine phosphate 42.9 24 9042950 (4), 1599956 (4), 2125244 (4)
    phosphocellulose 42.3 1 15066174 (1)
    retinoic acid 42 6 20074641 (2), 7861133 (1), 1997209 (1), 10802051 (1) (see all 5)
    estramustine 41.5 9 9042950 (4), 1599956 (1), 1647395 (1)
    glutamate 39 27 9332733 (3), 10582618 (3), 9776381 (2), 8789950 (2) (see all 16)
    paclitaxel 36.8 15 7591286 (6), 10963366 (2), 8819014 (1), 1338311 (1) (see all 7)
    nocodazole 36 4 1791975 (2), 16145685 (1), 8006079 (1)
    cerebrolysin 34.6 2 15347036 (1), 8841974 (1)

    Search CenterWatch for drugs/clinical trials and news about MAP2 / MTAP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAP2 gene (5 alternative transcripts): 
    NM_001039538.1  NM_002374.3  NM_031845.2  NM_031847.2  NM_031846.2  

    Unigene Cluster for MAP2:

    Microtubule-associated protein 2
    Hs.368281  [show with all ESTs]
    Unigene Representative Sequence: NM_002374
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000199940 ENST00000392193 ENST00000360351(uc002vdc.1 uc002vdd.1 uc002vde.1 uc002vdf.1 uc002vdg.1 uc002vdi.1)
    ENST00000361559 ENST00000445941 ENST00000392194(uc002vdh.1) ENST00000447185
    ENST00000452717 ENST00000471619 ENST00000482864 ENST00000461253 ENST00000481649
    ENST00000475600 ENST00000464007 ENST00000478233 ENST00000473543
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP2
    8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP2 (see all 61):
    hsa-miR-21* hsa-miR-361-5p hsa-miR-429 hsa-miR-4272 hsa-miR-374a hsa-miR-3138 hsa-miR-488 hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidMAP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP2
    Clone
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    OriGene ORF clones in mouse, rat for MAP2
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    GenScript: all cDNA clones in your preferred vector (see all 4): MAP2 (NM_031847)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP2
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP2

    Additional mRNA sequence: 

    AB209330.1 AF088065.1 AK055674.1 AK056148.1 AK291446.1 AK307603.1 AL833567.1 BC027583.1 
    BC038857.1 BC066648.1 BC110423.1 BC117123.1 BC143245.1 M25668.1 S76756.1 U01828.1 
    U89329.1 U89330.1 

    21 DOTS entries:

    DT.447934  DT.97843797  DT.100823230  DT.100027558  DT.100027557  DT.91707856  DT.100823225  DT.411466 
    DT.101981734  DT.95299768  DT.100027555  DT.99971548  DT.120944529  DT.120944532  DT.86850226  DT.91647992 
    DT.100027556  DT.75163039  DT.91707853  DT.95305705  DT.95326146 

    24/233 AceView cDNA sequences (see all 233):

    AL706554 BE327037 AF088065 AI887863 T32736 AA935811 AA364503 BG819395 
    BI917678 T28311 BC066648 M25668 BQ005183 R53131 AA747914 BC038857 
    AA788593 CB149848 BM762431 AA331387 BX111044 BU634096 BM925644 BM663357 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for MAP2 (see all 16)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
    SP1:        -           -     -           -                       -     -                       -     -     -     -     -     -                 -               
    SP2:                                      -                       -     -                                                                 -     -               
    SP3:                                                              -     -                       -     -     -     -     -     -                 -               
    SP4:                                                              -     -                       -                                         -     -               
    SP5:                                      -                       -     -                       -     -     -     -     -     -           -     -               

    ExUns: 20b · 20c · 20d ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25a · 25b · 25c · 25d
    SP1:                    -                                                         
    SP2:                    -     -                 -                                 
    SP3:                    -     -                                                   
    SP4:                    -     -                                                   
    SP5:                    -     -                                                   


    ECgene alternative splicing isoforms for MAP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP2 expression in normal human tissues (normalized intensities)      MAP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTCAATC
    MAP2 Expression
    About this image


    MAP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
             GABA neuron-like cells ( Generation of motor and gamma-aminobutyric acid (GABA)...
             ganglion   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
             PERIPHERAL NERVOUS SYSTEM   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Neural stem cells
             Motor neuron-like cells ( Differentiation of mouse neural stem cells into motor...
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle

    See MAP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP2

    SOURCE GeneReport for Unigene cluster: Hs.368281
        SABiosciences Expression via Pathway-Focused PCR Arrays including MAP2: 
              Neurogenesis in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Alzheimer's Disease in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MAP2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map25 microtubule-associated protein 2   --   1 (33.49 cM) 66175273 
    chicken
    (Gallus gallus)
    Aves MAP21 microtubule-associated protein 2 68.16(n)
    63.87(a)
      424001  XM_421857.2  XP_421857.2 
    lizard
    (Anolis carolinensis)
    Reptilia MAP26
    Microtubule-associated protein
    55(a)
    1 ↔ 1
    1(113000007-113122231)
    African clawed frog
    (Xenopus laevis)
    Amphibia a730034c02-prov2 microtubule-associated protein 2 77.43(n)    BC046689.1 
    zebrafish
    (Danio rerio)
    Actinopterygii map21 microtubule-associated protein 2 51.43(n)
    44.2(a)
      450004  XM_002663408.2  XP_002663454.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta tau6
    tau
    27(a)
    1 → many
    3R(23466365-23482718)


    ENSEMBL Gene Tree for MAP2 (if available)
    TreeFam Gene Tree for MAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP2 gene
    MAPT2  MAP42  
    1 SIMAP similar gene for MAP2 using alignment to 5 protein entries:     MTAP2_HUMAN (see all proteins):
    METAP2

    MAP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5709 SNPs in MAP2 are shown (see all 5709)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360154
    A colorectal cancer sample4--see VAR_0360152 P L mis40--------
    VAR_0360144
    A colorectal cancer sample4--see VAR_0360142 E D mis40--------
    rs1487581701,2
    Cuntested1210561708(+) AAATTC/G/TATTTT 5 F int1 syn10--------
    rs788019141,2
    C--209683677(+) GAACA-/TAAAATA 1 -- int10--------
    rs354118201,2
    C--210286856(+) GGAAA-/AAAC  
            
    AAACA
    1 -- us2k10--------
    rs1457452461,2
    C--210286856(+) GGAAA-/AAAC  
            
    AAACA
    1 -- us2k10--------
    rs792469061,2
    C,F--210286906(+) ACACTG/ATACTT 1 -- us2k12Minor allele frequency- A:0.05NA 122
    rs729956291,2
    C--210287075(+) GGTGTA/GAGCCA 1 -- us2k10--------
    rs1412631731,2
    --210287146(+) AATGTC/TAGCTG 1 -- us2k10--------
    rs730651621,2
    C,F--210287237(+) TCAGTA/GAGGCC 1 -- us2k12Minor allele frequency- G:0.13WA 120

    HapMap Linkage Disequilibrium report for MAP2 (210288771 - 210538771 bp, first 250kb of MAP2)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for MAP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678028CNV Deletion23128226
    esv2608148CNV Deletion19546169
    esv1055449CNV Insertion17803354
    nsv507065CNV Insertion20534489
    nsv3141CNV Insertion18451855
    nsv875765CNV Loss21882294
    nsv834518CNV Loss17160897
    nsv214706CNV Loss16902084
    nsv834519CNV Loss17160897


    Human Gene Mutation Database (HGMD): MAP2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 157130    OMIM disorders: --

    20/85 diseases for MAP2 (see all 85):    About MalaCards
    ehrlichiosis    human monocytic ehrlichiosis    pituicytoma    papillary tumour of the pineal region
    striatonigral degeneration    olivopontocerebellar atrophy    gliomatosis cerebri    brain ischemia
    transient cerebral ischemia    central neurocytoma    dysembryoplastic neuroepithelial tumor    subependymal giant cell astrocytoma
    neuronal migration disorders    rett syndrome    brain malformations    brain glioma
    ganglioglioma    ischemia    diffuse astrocytoma    multiple system atrophy

    5 diseases from the University of Copenhagen DISEASES database for MAP2:
    Alzheimer's disease     Vascular disease     Brain disease     Toxic encephalopathy
    Cancer

    MAP2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/78 Novoseek inferred disease relationships for MAP2 gene (see all 78)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paired helical filament 79.8 15 8955102 (3), 1373018 (2), 1707726 (1), 10527895 (1) (see all 10)
    neurofibrillary tangles 67.2 7 1707726 (1), 8954102 (1), 16104002 (1), 1335088 (1) (see all 6)
    neuroepithelial tumors 58.8 5 11589429 (2), 15146346 (1), 12670051 (1)
    alzheimers disease 58.6 13 7891887 (2), 8954102 (2), 8955102 (1), 10781592 (1) (see all 11)
    neuropil threads 57.4 1 9786247 (1)
    neurodegenerative diseases 52.5 1 10335552 (1)
    neurodegeneration 51 6 19101630 (1), 9974143 (1), 2013758 (1), 8051544 (1) (see all 5)
    cerebral ischemia 48.3 2 17199994 (1), 1722131 (1)
    gliosis 47.9 7 16400226 (2), 12605891 (1), 19587288 (1), 17562830 (1) (see all 6)
    senile plaques 46.1 2 1335088 (1), 9930899 (1)

    Genetic Association Database (GAD): MAP2
    Human Genome Epidemiology (HuGE) Navigator: MAP2 (7 documents)

    Export disorders for MAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP2 gene, integrated from 9 sources (see all 653):
    (articles sorted by number of sources associating them with MAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms. (PubMed id 7479905)1, 3, 9 Kalcheva N....Shafit-Zagardo B. (1995)
    2. Fyn phosphorylates human MAP-2c on tyrosine 67. (PubMed id 15536091)1, 2, 9 Zamora-Leon S.P....Shafit-Zagardo B. (2005)
    3. Characterization of the transcripts encoding two isoforms of human microtubule-associated protein-2 (MAP-2). (PubMed id 8294038)1, 2, 9 Albala J.S.... Shafit-Zagardo B. (1993)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Sequence of a human MAP-2 region sharing epitopes with Alzheimer neurofibrillary tangles. (PubMed id 2481044)1, 2 Dammerman M.... Shafit-Zagardo B. (1989)
    8. Partial sequence of MAP2 in the region of a shared epitope with Alzheimer neurofibrillary tangles. (PubMed id 2455776)1, 2 Kosik K.S.... Neve R.L. (1988)
    9. Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2. (PubMed id 3103857)1, 3 Neve R.L....Donlon T.A. (1986)
    10. Involvement of microtubule-associated protein 2 (MAP2) in oral cancer cell motility: a novel biological function of MAP2 in non-neuronal cells. (PubMed id 18073143)1, 9 Liu S.Y....Chen J.Y. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4133 HGNC: 6839 AceView: MAP2 Ensembl:ENSG00000078018 euGenes: HUgn4133
    ECgene: MAP2 H-InvDB: MAP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAP2 gene:
    Search GeneIP for patents involving MAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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