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Aliases for MAP2 Gene

Aliases for MAP2 Gene

  • Microtubule-Associated Protein 2 2 3
  • MAP-2 3 4
  • MAP2A 3
  • MAP2B 3
  • MAP2C 3

External Ids for MAP2 Gene

Previous GeneCards Identifiers for MAP2 Gene

  • GC02P208719
  • GC02P209169
  • GC02P210252
  • GC02P210491
  • GC02P210646
  • GC02P210114
  • GC02P209997
  • GC02P202133

Summaries for MAP2 Gene

Entrez Gene Summary for MAP2 Gene

  • This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]

GeneCards Summary for MAP2 Gene

MAP2 (Microtubule-Associated Protein 2) is a Protein Coding gene. Diseases associated with MAP2 include human monocytic ehrlichiosis and ehrlichiosis. Among its related pathways are TGF-Beta Pathway and SIDS Susceptibility Pathways. GO annotations related to this gene include structural molecule activity and microtubule binding. An important paralog of this gene is MAP4.

UniProtKB/Swiss-Prot for MAP2 Gene

  • The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules

Gene Wiki entry for MAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP2 Gene

Genomics for MAP2 Gene

Regulatory Elements for MAP2 Gene

Genomic Location for MAP2 Gene

Start:
209,424,009 bp from pter
End:
209,734,118 bp from pter
Size:
310,110 bases
Orientation:
Plus strand

Genomic View for MAP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP2 Gene

Proteins for MAP2 Gene

  • Protein details for MAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11137-MTAP2_HUMAN
    Recommended name:
    Microtubule-associated protein 2
    Protein Accession:
    P11137
    Secondary Accessions:
    • Q17S04
    • Q8IUX2
    • Q99975
    • Q99976

    Protein attributes for MAP2 Gene

    Size:
    1827 amino acids
    Molecular mass:
    199526 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP2 Gene

Proteomics data for MAP2 Gene at MOPED

Post-translational modifications for MAP2 Gene

  • Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Isoform 2/MAP2c is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MAP2 Gene

Domains for MAP2 Gene

Gene Families for MAP2 Gene

HGNC:
  • AKAP :A-kinase anchor proteins

Protein Domains for MAP2 Gene

Suggested Antigen Peptide Sequences for MAP2 Gene

Graphical View of Domain Structure for InterPro Entry

P11137

UniProtKB/Swiss-Prot:

MTAP2_HUMAN :
  • P11137
Similarity:
  • Contains 3 Tau/MAP repeats.
genes like me logo Genes that share domains with MAP2: view

Function for MAP2 Gene

Molecular function for MAP2 Gene

GENATLAS Biochemistry: microtubule (beta) associated protein 2,expressed in the cytoplasm of neural tissue and predominantly nuclear in germ cells,with an alternatively spliced isoform expressing exon 13 (MAP2+13),expressed in fetal oligodendrocytes during process extension and myelination,minimally expressed in normal mature CNS,expressed again in generating oligodendrocytes in multiple slcerosis lesions
UniProtKB/Swiss-Prot Function: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules

Gene Ontology (GO) - Molecular Function for MAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002162 dystroglycan binding IPI 18341635
GO:0005198 structural molecule activity NAS 9588626
GO:0005515 protein binding IPI 20195357
GO:0005516 calmodulin binding IEA --
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with MAP2: view
genes like me logo Genes that share phenotypes with MAP2: view

Animal Models for MAP2 Gene

MGI Knock Outs for MAP2:

miRNA for MAP2 Gene

miRTarBase miRNAs that target MAP2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MAP2 Gene

Localization for MAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP2 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP2 Gene COMPARTMENTS Subcellular localization image for MAP2 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
vacuole 3
cytosol 2
lysosome 2
mitochondrion 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005874 microtubule IEA --
GO:0005875 microtubule associated complex TAS 9588626
genes like me logo Genes that share ontologies with MAP2: view

Pathways for MAP2 Gene

genes like me logo Genes that share pathways with MAP2: view

Pathways by source for MAP2 Gene

1 Qiagen pathway for MAP2 Gene
1 Cell Signaling Technology pathway for MAP2 Gene
1 PharmGKB pathway for MAP2 Gene

Gene Ontology (GO) - Biological Process for MAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation IEA --
GO:0007409 axonogenesis IEA --
GO:0016358 dendrite development --
GO:0021954 central nervous system neuron development IEP 20846339
GO:0031175 neuron projection development IEP 20846339
genes like me logo Genes that share ontologies with MAP2: view

Compounds for MAP2 Gene

(3) Drugbank Compounds for MAP2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Docetaxel
  • Docetaxel anhydrous
114977-28-5 target
Estramustine
  • Estramustin Sodium Phosphate
2998-57-4 target antagonist
Paclitaxel
  • 7-epi-Paclitaxel
33069-62-4 target

(79) Novoseek inferred chemical compound relationships for MAP2 Gene

Compound -log(P) Hits PubMed IDs
map4 84.7 26
nmda 43.9 30
estramustine phosphate 42.9 12
phosphocellulose 42.3 1
retinoic acid 42 6
genes like me logo Genes that share compounds with MAP2: view

Transcripts for MAP2 Gene

Unigene Clusters for MAP2 Gene

Microtubule-associated protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c · 14d ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a ·
SP1: - - - - - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - -
SP9: - - - -
SP10: - - - - - - - -
SP11: - -
SP12: -
SP13: - - - - -
SP14: - -
SP15:
SP16:

ExUns: 20b · 20c · 20d ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24 ^ 25a · 25b · 25c · 25d
SP1: -
SP2: - - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for MAP2 Gene

GeneLoc Exon Structure for
MAP2
ECgene alternative splicing isoforms for
MAP2

Expression for MAP2 Gene

mRNA expression in normal human tissues for MAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (6.7), Brain - Frontal Cortex (BA9) (5.5), Brain - Cortex (5.3), Brain - Amygdala (5.2), Brain - Hypothalamus (4.4), Brain - Nucleus accumbens (basal ganglia) (4.3), and Brain - Hippocampus (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP2 Gene

SOURCE GeneReport for Unigene cluster for MAP2 Gene Hs.368281

genes like me logo Genes that share expressions with MAP2: view

No data available for mRNA Expression by UniProt/SwissProt for MAP2 Gene

Orthologs for MAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP2 35
  • 99.64 (n)
  • 99.45 (a)
MAP2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAP-2 36
  • 87 (a)
OneToOne
MAP2 35
  • 88.51 (n)
  • 87.89 (a)
dog
(Canis familiaris)
Mammalia MAP2 35
  • 86.12 (n)
  • 86.24 (a)
MAP2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map2 35
  • 86.8 (n)
  • 92.72 (a)
Map2 16
Map2 36
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP2 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP2 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map2 35
  • 82.94 (n)
  • 80.42 (a)
chicken
(Gallus gallus)
Aves MAP2 35
  • 68.5 (n)
  • 64.69 (a)
MAP2 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP2 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia a730034c02-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia map2 35
  • 72.82 (n)
  • 75.37 (a)
zebrafish
(Danio rerio)
Actinopterygii map2 36
  • 32 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tau 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ptl-1 36
  • 14 (a)
OneToMany
Species with no ortholog for MAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP2 Gene

ENSEMBL:
Gene Tree for MAP2 (if available)
TreeFam:
Gene Tree for MAP2 (if available)

Paralogs for MAP2 Gene

Paralogs for MAP2 Gene

genes like me logo Genes that share paralogs with MAP2: view

Variants for MAP2 Gene

Sequence variations from dbSNP and Humsavar for MAP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs169636 -- 209,572,754(+) CATAC(A/G)GATGT intron-variant
rs288043 -- 209,511,690(+) ctcag(C/G)ctcct intron-variant
rs288044 -- 209,511,749(+) ttatt(A/T)tttgt intron-variant
rs288045 -- 209,513,702(-) GAATA(C/T)AAAAA intron-variant
rs288046 -- 209,514,064(+) GAAGC(C/T)TTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP2 Gene

Variant ID Type Subtype PubMed ID
nsv834518 CNV Loss 17160897
nsv834519 CNV Loss 17160897
esv1055449 CNV Insertion 17803354
nsv214706 CNV Loss 16902084
esv2678028 CNV Deletion 23128226
nsv3141 CNV Insertion 18451855
esv2608148 CNV Deletion 19546169
nsv875765 CNV Loss 21882294
nsv507065 CNV Insertion 20534489

Relevant External Links for MAP2 Gene

HapMap Linkage Disequilibrium report
MAP2
Human Gene Mutation Database (HGMD)
MAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP2 Gene

Disorders for MAP2 Gene

(5) University of Copenhagen DISEASES for MAP2 Gene

(78) Novoseek inferred disease relationships for MAP2 Gene

Disease -log(P) Hits PubMed IDs
paired helical filament 79.8 13
neurofibrillary tangles 67.2 6
neuroepithelial tumors 58.8 4
alzheimers disease 58.6 13
neuropil threads 57.4 1

Relevant External Links for MAP2

Genetic Association Database (GAD)
MAP2
Human Genome Epidemiology (HuGE) Navigator
MAP2
genes like me logo Genes that share disorders with MAP2: view

No data available for UniProtKB/Swiss-Prot for MAP2 Gene

Publications for MAP2 Gene

  1. Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms. (PMID: 7479905) Kalcheva N. … Shafit-Zagardo B. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 23
  2. Characterization of the transcripts encoding two isoforms of human microtubule-associated protein-2 (MAP-2). (PMID: 8294038) Albala J.S. … Shafit-Zagardo B. (Gene 1993) 3 4 23
  3. Fyn phosphorylates human MAP-2c on tyrosine 67. (PMID: 15536091) Zamora-Leon S.P. … Shafit-Zagardo B. (J. Biol. Chem. 2005) 3 4 23
  4. MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes. (PMID: 14594945) Trinczek B. … Drewes G. (J. Biol. Chem. 2004) 3 23
  5. Specific induction of the high-molecular-weight microtubule-associated protein 2 (hmw-MAP2) by betel quid extract in cultured oral keratinocytes: clinical implications in betel quid-associated oral squamous cell carcinoma (OSCC). (PMID: 14604896) Chen J.Y. … Jou Y.S. (Carcinogenesis 2004) 3 23

Products for MAP2 Gene

Sources for MAP2 Gene

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