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Aliases for MAP1S Gene

Aliases for MAP1S Gene

  • Microtubule Associated Protein 1S 2 3 5
  • Variable Charge Y Chromosome 2-Interacting Protein 1 3 4
  • Microtubule-Associated Protein 8 3 4
  • BPY2-Interacting Protein 1 3 4
  • VCY2-Interacting Protein 1 3 4
  • VCY2IP-1 3 4
  • BPY2IP1 3 4
  • C19orf5 3 4
  • VCY2IP1 3 4
  • MAP-1S 3 4
  • MAP8 3 4
  • Chromosome 19 Open Reading Frame 5 2
  • Microtubule-Associated Protein 1S 3
  • VCY2 Interacting Protein 1 2
  • BPY2 Interacting Protein 1 2

External Ids for MAP1S Gene

Previous HGNC Symbols for MAP1S Gene

  • C19orf5
  • VCY2IP1
  • BPY2IP1

Previous GeneCards Identifiers for MAP1S Gene

  • GC19P017694
  • GC19P017832
  • GC19P017396
  • GC19P017932
  • GC19P018136
  • GC19P018154
  • GC19P018321

Summaries for MAP1S Gene

GeneCards Summary for MAP1S Gene

MAP1S (Microtubule Associated Protein 1S) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and actin filament binding. An important paralog of this gene is MAP1B.

UniProtKB/Swiss-Prot for MAP1S Gene

  • Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity).

Gene Wiki entry for MAP1S Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP1S Gene

Genomics for MAP1S Gene

Regulatory Elements for MAP1S Gene

Enhancers for MAP1S Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F017764 1.3 Ensembl ENCODE 12.2 +46.6 46597 3.1 PKNOX1 ATF1 MLX ARID4B DMAP1 ZNF48 ZNF2 GTF3C2 SLC30A9 GLIS2 MVB12A ENSG00000268030 B3GNT3 UNC13A MAP1S INSL3 ANO8 PLVAP ENSG00000268938 FCHO1
GH19F017738 1.2 Ensembl ENCODE 13.1 +20.1 20112 1.3 ELF3 CBX3 KLF17 BMI1 ZBTB40 ZNF121 GTF3C2 EGR1 ZNF143 ETV6 ENSG00000268030 MAP1S MVB12A B3GNT3 ENSG00000268938 FCHO1 GC19P019194
GH19F017743 1 Ensembl ENCODE 13.1 +25.0 24960 0.8 BCOR MXI1 PKNOX1 KLF1 JUN BMI1 RFX5 FOS ZNF548 RFX1 FCHO1 MAP1S ENSG00000268030 COLGALT1 B3GNT3 ENSG00000268743 GC19P019194
GH19F017762 0.9 ENCODE 12.4 +43.5 43469 1.1 YBX3 HDGF HDAC1 ATF1 PKNOX1 SIN3A BMI1 ZNF2 RFX5 ZNF335 MAP1S B3GNT3 INSL3 PLVAP NXNL1 F2RL3 GC19M017755 GC19P019215
GH19F017716 0.9 ENCODE 7.5 -1.8 -1801 1.1 HDAC1 NFXL1 ZBTB40 RAD21 ZNF121 ELK1 GATA2 SIRT6 ETV6 CREM UNC13A B3GNT3 MAP1S PIR50741
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAP1S on UCSC Golden Path with GeneCards custom track

Promoters for MAP1S Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000344539 558 1601 PKNOX1 WRNIP1 ARID4B DMAP1 ZNF2 YY1 GLIS2 ELK1 ZNF143 KLF7

Genomic Location for MAP1S Gene

Chromosome:
19
Start:
17,719,242 bp from pter
End:
17,734,516 bp from pter
Size:
15,275 bases
Orientation:
Plus strand

Genomic View for MAP1S Gene

Genes around MAP1S on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP1S Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP1S Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP1S Gene

Proteins for MAP1S Gene

  • Protein details for MAP1S Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q66K74-MAP1S_HUMAN
    Recommended name:
    Microtubule-associated protein 1S
    Protein Accession:
    Q66K74
    Secondary Accessions:
    • B4DH53
    • Q27QB1
    • Q6NXF1
    • Q8N3L8
    • Q8N3W5
    • Q8NI88
    • Q96H94
    • Q96IT4
    • Q96SP8
    • Q9BRC6
    • Q9H928
    • Q9NVK7

    Protein attributes for MAP1S Gene

    Size:
    1059 amino acids
    Molecular mass:
    112211 Da
    Quaternary structure:
    • Heterodimer of a heavy and a light chain. Interacts with microtubules and actin. Both MAP1S heavy and light chains interact with microtubules. MAP1S light chain interacts with actin. Interacts (via C-terminus) with GAN (via Kelch domains) (By similarity). Interacts with ESR1, LRPPRC, RASSF1 isoform A and isoform C, microtubules and VCY2. Interacts with WDR47 (via N-terminus of light chain).
    Miscellaneous:
    • Depletion of MAP1S by RNAi causes mitotic abnormalities that consist of failure to form a stable metaphase plate, premature sister chromatid separation, lagging chromosomes, and multipolar spindles.
    SequenceCaution:
    • Sequence=AAH07253.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH07253.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. At the N-terminus.; Evidence={ECO:0000305}; Sequence=AAH67115.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91743.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14415.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55242.1; Type=Frameshift; Positions=851; Evidence={ECO:0000305}; Sequence=BAB93493.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD38911.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MAP1S Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP1S Gene

Post-translational modifications for MAP1S Gene

  • Ubiquitination at Lys 73, Lys 380, and Lys 1000
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MAP1S Gene

Domains & Families for MAP1S Gene

Protein Domains for MAP1S Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q66K74

UniProtKB/Swiss-Prot:

MAP1S_HUMAN :
  • The N-terminus of the heavy chain associates with the C-terminus of the light chain to form the heterodimer complex (By similarity). Its C-terminal part of the heavy chain interacts with ESR1.
  • Belongs to the MAP1 family.
Domain:
  • The N-terminus of the heavy chain associates with the C-terminus of the light chain to form the heterodimer complex (By similarity). Its C-terminal part of the heavy chain interacts with ESR1.
Family:
  • Belongs to the MAP1 family.
genes like me logo Genes that share domains with MAP1S: view

No data available for Gene Families for MAP1S Gene

Function for MAP1S Gene

Molecular function for MAP1S Gene

UniProtKB/Swiss-Prot Function:
Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis. Involved in the formation of microtubule bundles (By similarity).

Gene Ontology (GO) - Molecular Function for MAP1S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 15907802
GO:0004536 NOT deoxyribonuclease activity IDA 15907802
GO:0005515 protein binding IPI 12762840
GO:0008017 microtubule binding IEA,TAS 12762840
GO:0015631 tubulin binding IDA 15528209
genes like me logo Genes that share ontologies with MAP1S: view
genes like me logo Genes that share phenotypes with MAP1S: view

Animal Models for MAP1S Gene

MGI Knock Outs for MAP1S:

Animal Model Products

miRNA for MAP1S Gene

miRTarBase miRNAs that target MAP1S

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP1S Gene

Localization for MAP1S Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP1S Gene

Nucleus. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Detected in filopodia-like protrusions and synapses (By similarity). Detected in perinuclear punctate network corresponding to mitochondrial aggregates and in the nucleus in cells exhibiting apoptosis. Associated specifically with microtubules stabilized by paclitaxel and colocalizes with RASSF1 isoform A. In interphase cells, shows a diffuse cytoplasmic staining with partial localization to the microtubules. During the different stages of mitosis detected at the spindle microtubules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP1S gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MAP1S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12762840
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005819 spindle IEA --
GO:0005829 cytosol IDA 12762840
genes like me logo Genes that share ontologies with MAP1S: view

Pathways & Interactions for MAP1S Gene

SuperPathways for MAP1S Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAP1S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation IMP 15528209
GO:0006914 autophagy TAS 21262964
GO:0006915 apoptotic process IEA --
GO:0007399 nervous system development ISS 16297881
GO:0007420 brain development ISS 15528209
genes like me logo Genes that share ontologies with MAP1S: view

No data available for Pathways by source and SIGNOR curated interactions for MAP1S Gene

Transcripts for MAP1S Gene

Unigene Clusters for MAP1S Gene

Microtubule-associated protein 1S:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP1S Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8
SP1: - -
SP2: - - -
SP3: -
SP4: -
SP5:

Relevant External Links for MAP1S Gene

GeneLoc Exon Structure for
MAP1S
ECgene alternative splicing isoforms for
MAP1S

Expression for MAP1S Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAP1S Gene

Protein differential expression in normal tissues from HIPED for MAP1S Gene

This gene is overexpressed in Lymph node (7.1), Peripheral blood mononuclear cells (6.2), and Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP1S Gene



Protein tissue co-expression partners for MAP1S Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAP1S Gene:

MAP1S

SOURCE GeneReport for Unigene cluster for MAP1S Gene:

Hs.66048

mRNA Expression by UniProt/SwissProt for MAP1S Gene:

Q66K74-MAP1S_HUMAN
Tissue specificity: Expressed in neurons (at protein level). Expressed in spermatocytes, spermatids and spermatozoa. Expressed in the cerebral cortex. Highly expressed in testis. Moderately expressed in the brain, colon, heart, kidney, liver, lung, placenta, small intestine, spleen and stomach. Weakly expressed in muscle.
genes like me logo Genes that share expression patterns with MAP1S: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MAP1S Gene

Orthologs for MAP1S Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP1S Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP1S 34 35
  • 98.99 (n)
cow
(Bos Taurus)
Mammalia MAP1S 34 35
  • 83.29 (n)
dog
(Canis familiaris)
Mammalia MAP1S 34 35
  • 82.96 (n)
rat
(Rattus norvegicus)
Mammalia Map1s 34
  • 71.57 (n)
mouse
(Mus musculus)
Mammalia Map1s 34 16 35
  • 70.82 (n)
oppossum
(Monodelphis domestica)
Mammalia MAP1S 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP1S 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP1S 35
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii MAP1S (2 of 2) 35
  • 35 (a)
OneToMany
MAP1S (1 of 2) 35
  • 32 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta futsch 35
  • 5 (a)
ManyToMany
dp 35
  • 1 (a)
ManyToMany
Species where no ortholog for MAP1S was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP1S Gene

ENSEMBL:
Gene Tree for MAP1S (if available)
TreeFam:
Gene Tree for MAP1S (if available)

Paralogs for MAP1S Gene

Paralogs for MAP1S Gene

genes like me logo Genes that share paralogs with MAP1S: view

Variants for MAP1S Gene

Sequence variations from dbSNP and Humsavar for MAP1S Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401951 -- 17,718,606(+) gggga(A/G)gagag upstream-variant-2KB
rs10403828 -- 17,718,763(+) CAGGC(C/T)TGGTG upstream-variant-2KB
rs10404176 -- 17,718,584(+) gggag(A/G)agagg upstream-variant-2KB
rs10405032 -- 17,718,908(+) AAAAT(A/G)CCTGG upstream-variant-2KB
rs10410487 -- 17,718,799(+) CCTCT(C/T)CTTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAP1S Gene

Variant ID Type Subtype PubMed ID
nsv1117214 CNV tandem duplication 24896259
esv1349147 CNV insertion 17803354
dgv50n68 CNV loss 17160897

Variation tolerance for MAP1S Gene

Residual Variation Intolerance Score: 34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.86; 87.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP1S Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP1S

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP1S Gene

Disorders for MAP1S Gene

Relevant External Links for MAP1S

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP1S

No disorders were found for MAP1S Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP1S Gene

Publications for MAP1S Gene

  1. Identification and characterization of a VCY2 interacting protein-1; VCY2IP-1, a MAP-like protein. (PMID: 14627543) Wong E.Y. … Yeung W.S. (Biol. Reprod. 2004) 2 3 4 22 64
  2. Microtubule-associated protein 8 contains two microtubule binding sites. (PMID: 16297881) Ding J. … Yang Y. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 64
  3. Microtubule-associated protein 1S, a short and ubiquitously expressed member of the microtubule-associated protein 1 family. (PMID: 15528209) OrbA!n-NAcmeth Z. … Propst F. (J. Biol. Chem. 2005) 2 3 22 64
  4. Putative tumor suppressor RASSF1 interactive protein and cell death inducer C19ORF5 is a DNA binding protein. (PMID: 15907802) Liu L. … McKeehan W.L. (Biochem. Biophys. Res. Commun. 2005) 3 4 22 64
  5. Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity. (PMID: 11827465) Liu L. … McKeehan W.L. (Genomics 2002) 2 3 4 64

Products for MAP1S Gene

Sources for MAP1S Gene

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