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Aliases for MAP1LC3C Gene

Aliases for MAP1LC3C Gene

  • Microtubule-Associated Protein 1 Light Chain 3 Gamma 2 3 4
  • Autophagy-Related Ubiquitin-Like Modifier LC3 C 3 4
  • MAP1 Light Chain 3-Like Protein 3 3 4
  • Autophagy-Related Protein LC3 C 3 4
  • MAP1A/MAP1B Light Chain 3 C 3 4
  • MAP1A/MAP1B LC3 C 3 4
  • Microtubule-Associated Proteins 1A/1B Light Chain 3C 3
  • MAP1 Light Chain 3-Like Protein 2 3
  • LC3-Like Protein 2 3
  • ATG8J 3
  • LC3C 3

External Ids for MAP1LC3C Gene

Previous GeneCards Identifiers for MAP1LC3C Gene

  • GC01M238485
  • GC01M240225
  • GC01M242158
  • GC01M212618

Summaries for MAP1LC3C Gene

Entrez Gene Summary for MAP1LC3C Gene

  • Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).[supplied by OMIM, Nov 2010]

GeneCards Summary for MAP1LC3C Gene

MAP1LC3C (Microtubule-Associated Protein 1 Light Chain 3 Gamma) is a Protein Coding gene. Among its related pathways are Senescence and Autophagy. An important paralog of this gene is GABARAP.

UniProtKB/Swiss-Prot for MAP1LC3C Gene

  • Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP1LC3C Gene

Genomics for MAP1LC3C Gene

Regulatory Elements for MAP1LC3C Gene

Genomic Location for MAP1LC3C Gene

Start:
241,995,490 bp from pter
End:
242,001,328 bp from pter
Size:
5,839 bases
Orientation:
Minus strand

Genomic View for MAP1LC3C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP1LC3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP1LC3C Gene

Proteins for MAP1LC3C Gene

  • Protein details for MAP1LC3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXW4-MLP3C_HUMAN
    Recommended name:
    Microtubule-associated proteins 1A/1B light chain 3C
    Protein Accession:
    Q9BXW4
    Secondary Accessions:
    • A0PJY8
    • A2RUP0

    Protein attributes for MAP1LC3C Gene

    Size:
    147 amino acids
    Molecular mass:
    16852 Da
    Quaternary structure:
    • 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts with TP53INP1 and TP53INP2. Interacts with CALCOCO2. Interacts with TECPR2. Interacts with TBC1D5 (PubMed:22354992).

    Three dimensional structures from OCA and Proteopedia for MAP1LC3C Gene

neXtProt entry for MAP1LC3C Gene

Proteomics data for MAP1LC3C Gene at MOPED

Post-translational modifications for MAP1LC3C Gene

  • The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.
  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II (PubMed:15187094).

Other Protein References for MAP1LC3C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAP1LC3C Gene

Domains for MAP1LC3C Gene

Protein Domains for MAP1LC3C Gene

Suggested Antigen Peptide Sequences for MAP1LC3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXW4

UniProtKB/Swiss-Prot:

MLP3C_HUMAN :
  • Q9BXW4
Family:
  • Belongs to the ATG8 family.
genes like me logo Genes that share domains with MAP1LC3C: view

No data available for Gene Families for MAP1LC3C Gene

Function for MAP1LC3C Gene

Molecular function for MAP1LC3C Gene

UniProtKB/Swiss-Prot Function: Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.

Gene Ontology (GO) - Molecular Function for MAP1LC3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19250911
GO:0008017 microtubule binding IBA --
genes like me logo Genes that share ontologies with MAP1LC3C: view

Phenotypes for MAP1LC3C Gene

GenomeRNAi human phenotypes for MAP1LC3C:
genes like me logo Genes that share phenotypes with MAP1LC3C: view

miRNA for MAP1LC3C Gene

miRTarBase miRNAs that target MAP1LC3C

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAP1LC3C Gene

Localization for MAP1LC3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP1LC3C Gene

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP1LC3C Gene COMPARTMENTS Subcellular localization image for MAP1LC3C gene
Compartment Confidence
cytoskeleton 5
vacuole 5
mitochondrion 3
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for MAP1LC3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IBA --
GO:0000421 autophagic vacuole membrane IBA --
GO:0005737 cytoplasm --
GO:0005776 autophagic vacuole ISS 12740394
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with MAP1LC3C: view

Pathways for MAP1LC3C Gene

SuperPathways for MAP1LC3C Gene

Superpath Contained pathways
1 Senescence and Autophagy
genes like me logo Genes that share pathways with MAP1LC3C: view

Pathways by source for MAP1LC3C Gene

1 BioSystems pathway for MAP1LC3C Gene

Gene Ontology (GO) - Biological Process for MAP1LC3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IBA --
GO:0000422 mitochondrion degradation IBA --
GO:0006914 autophagy --
GO:0006995 cellular response to nitrogen starvation IBA --
GO:0044804 nucleophagy IBA --
genes like me logo Genes that share ontologies with MAP1LC3C: view

Transcripts for MAP1LC3C Gene

mRNA/cDNA for MAP1LC3C Gene

(2) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAP1LC3C Gene

Microtubule-associated protein 1 light chain 3 gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP1LC3C Gene

No ASD Table

Relevant External Links for MAP1LC3C Gene

GeneLoc Exon Structure for
MAP1LC3C
ECgene alternative splicing isoforms for
MAP1LC3C

Expression for MAP1LC3C Gene

mRNA expression in normal human tissues for MAP1LC3C Gene

mRNA differential expression in normal tissues according to GTEx for MAP1LC3C Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (7.6), Adipose - Subcutaneous (7.2), and Breast - Mammary Tissue (5.3).

SOURCE GeneReport for Unigene cluster for MAP1LC3C Gene Hs.534971

mRNA Expression by UniProt/SwissProt for MAP1LC3C Gene

Q9BXW4-MLP3C_HUMAN
Tissue specificity: Most abundant in placenta, lung and ovary.
genes like me logo Genes that share expressions with MAP1LC3C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for MAP1LC3C Gene

Orthologs for MAP1LC3C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP1LC3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP1LC3C 35
  • 98.87 (n)
  • 98.64 (a)
MAP1LC3C 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC507432 35
  • 88.66 (n)
  • 85.71 (a)
MAP1LC3C 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP1LC3C 35
  • 87.95 (n)
  • 86.92 (a)
MAP1LC3C 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP1LC3C 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP1LC3C 35
  • 74.93 (n)
  • 80.99 (a)
MAP1LC3C 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP1LC3C 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map1lc3c 35
  • 68.68 (n)
  • 76.72 (a)
zebrafish
(Danio rerio)
Actinopterygii map1lc3c 35
  • 72.22 (n)
  • 72.22 (a)
map1lc3c 36
  • 71 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG8 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToOne
Species with no ortholog for MAP1LC3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP1LC3C Gene

ENSEMBL:
Gene Tree for MAP1LC3C (if available)
TreeFam:
Gene Tree for MAP1LC3C (if available)

Paralogs for MAP1LC3C Gene

Paralogs for MAP1LC3C Gene

Selected SIMAP similar genes for MAP1LC3C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAP1LC3C: view

Variants for MAP1LC3C Gene

Sequence variations from dbSNP and Humsavar for MAP1LC3C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2049066 -- 241,997,114(+) GGCTG(C/G)TCTTG intron-variant
rs2049067 -- 241,998,317(+) CCGCC(A/C)GGGGT intron-variant
rs2139473 -- 242,000,580(+) TTCCC(A/G)CAGCC upstream-variant-2KB, intron-variant
rs2139474 -- 242,000,641(+) AACAC(A/T)TTTAC upstream-variant-2KB, intron-variant
rs3795639 -- 241,999,223(+) GAATC(A/G)CCACC upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP1LC3C Gene

Variant ID Type Subtype PubMed ID
nsv873368 CNV Gain 21882294
nsv873372 CNV Gain 21882294
dgv16e55 CNV Gain 17911159
nsv508703 CNV Loss 20534489

Relevant External Links for MAP1LC3C Gene

HapMap Linkage Disequilibrium report
MAP1LC3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP1LC3C Gene

Disorders for MAP1LC3C Gene

(1) University of Copenhagen DISEASES for MAP1LC3C Gene

genes like me logo Genes that share disorders with MAP1LC3C: view

No data available for UniProtKB/Swiss-Prot for MAP1LC3C Gene

Publications for MAP1LC3C Gene

  1. Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. (PMID: 12740394) He H. … Yu L. (J. Biol. Chem. 2003) 2 3 4
  2. HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. (PMID: 15187094) Tanida I. … Kominami E. (J. Biol. Chem. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Network organization of the human autophagy system. (PMID: 20562859) Behrends C. … Harper J.W. (Nature 2010) 3 4

Products for MAP1LC3C Gene

Sources for MAP1LC3C Gene

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