Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MAP1LC3C Gene

Aliases for MAP1LC3C Gene

  • Microtubule Associated Protein 1 Light Chain 3 Gamma 2 3 5
  • Microtubule-Associated Protein 1 Light Chain 3 Gamma 3 4
  • Autophagy-Related Ubiquitin-Like Modifier LC3 C 3 4
  • MAP1 Light Chain 3-Like Protein 3 3 4
  • Autophagy-Related Protein LC3 C 3 4
  • MAP1A/MAP1B Light Chain 3 C 3 4
  • MAP1A/MAP1B LC3 C 3 4
  • MAP1 Light Chain 3-Like Protein 2 3
  • LC3-Like Protein 2 3
  • ATG8J 3
  • LC3C 3

External Ids for MAP1LC3C Gene

Previous GeneCards Identifiers for MAP1LC3C Gene

  • GC01M238485
  • GC01M240225
  • GC01M242158
  • GC01M212618

Summaries for MAP1LC3C Gene

Entrez Gene Summary for MAP1LC3C Gene

  • Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).[supplied by OMIM, Nov 2010]

GeneCards Summary for MAP1LC3C Gene

MAP1LC3C (Microtubule Associated Protein 1 Light Chain 3 Gamma) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Senescence and Autophagy. GO annotations related to this gene include microtubule binding. An important paralog of this gene is GABARAP.

UniProtKB/Swiss-Prot for MAP1LC3C Gene

  • Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP1LC3C Gene

Genomics for MAP1LC3C Gene

Regulatory Elements for MAP1LC3C Gene

Enhancers for MAP1LC3C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAP1LC3C on UCSC Golden Path with GeneCards custom track

Genomic Location for MAP1LC3C Gene

241,995,490 bp from pter
242,001,399 bp from pter
5,910 bases
Minus strand

Genomic View for MAP1LC3C Gene

Genes around MAP1LC3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP1LC3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP1LC3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP1LC3C Gene

Proteins for MAP1LC3C Gene

  • Protein details for MAP1LC3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Microtubule-associated proteins 1A/1B light chain 3C
    Protein Accession:
    Secondary Accessions:
    • A0PJY8
    • A2RUP0

    Protein attributes for MAP1LC3C Gene

    147 amino acids
    Molecular mass:
    16852 Da
    Quaternary structure:
    • 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts with TP53INP1 and TP53INP2. Interacts with CALCOCO2. Interacts with TECPR2. Interacts with TBC1D5 (PubMed:22354992). Found in a complex with UBQLN1 and UBQLN2. Interacts with UBQLN4 (via STI1 1 and 2 domains). Interacts with UBQLN1 in the presence of UBQLN4. Interacts with TRIM5 (PubMed:25127057). Interacts with MEFV and TRIM21 (PubMed:26347139).

    Three dimensional structures from OCA and Proteopedia for MAP1LC3C Gene

neXtProt entry for MAP1LC3C Gene

Proteomics data for MAP1LC3C Gene at MOPED

Post-translational modifications for MAP1LC3C Gene

  • The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.
  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II (PubMed:15187094).

Other Protein References for MAP1LC3C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAP1LC3C (LC3C)
  • Abcam antibodies for LC3C

No data available for DME Specific Peptides for MAP1LC3C Gene

Domains & Families for MAP1LC3C Gene

Gene Families for MAP1LC3C Gene

Protein Domains for MAP1LC3C Gene

Suggested Antigen Peptide Sequences for MAP1LC3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ATG8 family.
  • Belongs to the ATG8 family.
genes like me logo Genes that share domains with MAP1LC3C: view

Function for MAP1LC3C Gene

Molecular function for MAP1LC3C Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.

Phenotypes for MAP1LC3C Gene

genes like me logo Genes that share phenotypes with MAP1LC3C: view

Animal Model Products

CRISPR Products

miRNA for MAP1LC3C Gene

miRTarBase miRNAs that target MAP1LC3C

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP1LC3C Gene

Localization for MAP1LC3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP1LC3C Gene

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome. Note=LC3-II binds to the autophagic membranes.

Subcellular locations from

Jensen Localization Image for MAP1LC3C Gene COMPARTMENTS Subcellular localization image for MAP1LC3C gene
Compartment Confidence
vacuole 5
cytosol 4
cytoskeleton 3
mitochondrion 3
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MAP1LC3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane TAS --
GO:0005776 autophagosome ISS 12740394
GO:0005829 cytosol TAS --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with MAP1LC3C: view

Pathways & Interactions for MAP1LC3C Gene

genes like me logo Genes that share pathways with MAP1LC3C: view

Pathways by source for MAP1LC3C Gene

1 GeneTex pathway for MAP1LC3C Gene
1 BioSystems pathway for MAP1LC3C Gene
2 Reactome pathways for MAP1LC3C Gene

SIGNOR curated interactions for MAP1LC3C Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAP1LC3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000422 mitophagy IBA --
genes like me logo Genes that share ontologies with MAP1LC3C: view

Drugs & Compounds for MAP1LC3C Gene

No Compound Related Data Available

Transcripts for MAP1LC3C Gene

mRNA/cDNA for MAP1LC3C Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAP1LC3C Gene

Microtubule-associated protein 1 light chain 3 gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP1LC3C Gene

No ASD Table

Relevant External Links for MAP1LC3C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP1LC3C Gene

mRNA expression in normal human tissues for MAP1LC3C Gene

mRNA differential expression in normal tissues according to GTEx for MAP1LC3C Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x7.6), Adipose - Subcutaneous (x7.2), and Breast - Mammary Tissue (x5.3).

SOURCE GeneReport for Unigene cluster for MAP1LC3C Gene Hs.534971

mRNA Expression by UniProt/SwissProt for MAP1LC3C Gene

Tissue specificity: Most abundant in placenta, lung and ovary.
genes like me logo Genes that share expression patterns with MAP1LC3C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MAP1LC3C Gene

Orthologs for MAP1LC3C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP1LC3C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC507432 35
  • 88.66 (n)
  • 85.71 (a)
  • 84 (a)
(Canis familiaris)
Mammalia MAP1LC3C 35
  • 87.95 (n)
  • 86.92 (a)
  • 69 (a)
(Pan troglodytes)
Mammalia MAP1LC3C 35
  • 98.87 (n)
  • 98.64 (a)
  • 99 (a)
(Monodelphis domestica)
Mammalia MAP1LC3C 36
  • 77 (a)
(Gallus gallus)
Aves MAP1LC3C 35
  • 74.93 (n)
  • 80.99 (a)
  • 71 (a)
(Anolis carolinensis)
Reptilia MAP1LC3C 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia map1lc3c 35
  • 68.68 (n)
  • 76.72 (a)
(Danio rerio)
Actinopterygii map1lc3c 35
  • 72.22 (n)
  • 72.22 (a)
map1lc3c 36
  • 71 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG8 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
Species with no ortholog for MAP1LC3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP1LC3C Gene

Gene Tree for MAP1LC3C (if available)
Gene Tree for MAP1LC3C (if available)

Paralogs for MAP1LC3C Gene

Paralogs for MAP1LC3C Gene

(8) SIMAP similar genes for MAP1LC3C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAP1LC3C: view

Variants for MAP1LC3C Gene

Sequence variations from dbSNP and Humsavar for MAP1LC3C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2139473 -- 242,000,580(+) TTCCC(A/G)CAGCC intron-variant, upstream-variant-2KB
rs2139474 -- 242,000,641(+) AACAC(A/T)TTTAC intron-variant, upstream-variant-2KB
rs2049066 -- 241,997,114(+) GGCTG(C/G)TCTTG intron-variant
rs2049067 -- 241,998,317(+) CCGCC(A/C)GGGGT intron-variant
rs3795639 -- 241,999,223(+) GAATC(A/G)CCACC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAP1LC3C Gene

Variant ID Type Subtype PubMed ID
nsv873368 CNV Gain 21882294
nsv873372 CNV Gain 21882294
dgv16e55 CNV Gain 17911159
nsv508703 CNV Loss 20534489

Variation tolerance for MAP1LC3C Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.61% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MAP1LC3C Gene

Disorders for MAP1LC3C Gene

Relevant External Links for MAP1LC3C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MAP1LC3C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP1LC3C Gene

Publications for MAP1LC3C Gene

  1. Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. (PMID: 12740394) He H. … Yu L. (J. Biol. Chem. 2003) 2 3 4 67
  2. HIV-1 viral infectivity factor interacts with microtubule-associated protein light chain 3 and inhibits autophagy. (PMID: 25490467) Borel S. … Biard-Piechaczyk M. (AIDS 2015) 3
  3. CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling. (PMID: 25684205) Genau H.M. … Behrends C. (Mol. Cell 2015) 3
  4. Autophagy receptor NDP52 regulates pathogen-containing autophagosome maturation. (PMID: 25771791) Verlhac P. … Faure M. (Cell Host Microbe 2015) 3
  5. The HIV proteins Tat and Nef promote human bone marrow mesenchymal stem cell senescence and alter osteoblastic differentiation. (PMID: 25847297) Beaupere C. … Lagathu C. (Aging Cell 2015) 3

Products for MAP1LC3C Gene

Sources for MAP1LC3C Gene