MAP1LC3B2 Gene
protein-coding GIFtS: 38
GCID: GC12P116997
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microtubule-associated protein 1 light chain 3 beta 2
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Aliases
for MAP1LC3B2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Microtubule-Associated Protein 1 Light Chain 3 Beta 21 2 | | ATG8G1 2 | | Microtubule-Associated Proteins 1A/1B Light Chain 3 Beta 22 | | Microtubule-Associated Proteins 1A/1B Light Chain 3B-Like Protein2 | | Microtubule-Associated Proteins 1A/1B Light Chain 3B-Like3 |
Export aliases for MAP1LC3B2 gene to outside databasesPrevious GC identifers: GC12P115483 GC12P114006 |
Summaries
for MAP1LC3B2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MP3B2_HUMAN, A6NCE7Function: Probably involved in formation of autophagosomal vacuoles (autophagosomes) (By similarity)
|
Genomic Views
for MAP1LC3B2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009775.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MAP1LC3B2 gene promoter:
Pbx1a GCNF POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) STAT5A POU3F2 E47 GCNF-1 MRF-2 GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MAP1LC3B2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP1LC3B2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.22 Ensembl cytogenetic band: 12q24.22 HGNC cytogenetic band: 12q24.22MAP1LC3B2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P116997: view genomic region
(about GC identifiers)
Start:
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116,997,186 bp from pter |
End:
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117,014,425 bp from pter |
Size:
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17,240 bases |
Orientation:
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plus strand |
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Proteins
for MAP1LC3B2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: MP3B2_HUMAN, A6NCE7 (See
protein sequence)Recommended Name: Microtubule-associated proteins 1A/1B light chain 3 beta 2 precursor Size: 125 amino acids; 14628 Da
Subunit: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Endomembrane system; Lipid-anchor (By similarity).Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor (By similarity). Note=LC3-II binds to the autophagicmembranes (By similarity)Explore the universe of human proteins at neXtProt for MAP1LC3B2: NX_A6NCE7
Post-translational modifications:
The precursor molecule is cleaved by APG4B/ATG4B to form LC3-I (By similarity). This is activated by APG7L/ATG7,transferred to ATG3 and conjugated to phospholipid to form LC3-II (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NCE7
MAP1LC3B2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001078950.1
ENSEMBL proteins: ENSP00000450524 ENSP00000305059
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
MAP1LC3B2 for ontologies About GeneDecksing
MAP1LC3B2 Antibody Products:
Assay Products for MAP1LC3B2: |
Protein
Domains /
Families
for MAP1LC3B2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MAP1LC3B2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A6NCE7ProtoNet protein and cluster: A6NCE7 UniProtKB/Swiss-Prot: MP3B2_HUMAN, A6NCE7Similarity: Belongs to the MAP1 LC3 family |
Function
for MAP1LC3B2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: MP3B2_HUMAN, A6NCE7Function: Probably involved in formation of autophagosomal vacuoles (autophagosomes) (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP1LC3B2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP1LC3B2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MAP1LC3B2 (NM_001085481) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAP1LC3B2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP1LC3B2 |
|
Pathways & Interactions
for MAP1LC3B2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAP1LC3B2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/11 Interacting proteins for MAP1LC3B2 (A6NCE73 ENSP000003050594) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006914 | autophagy |
IEA | -- |
MAP1LC3B2 for ontologies About GeneDecksing
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Drugs & Compounds
for MAP1LC3B2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MAP1LC3B2
Search CenterWatch for drugs/clinical trials and news about MAP1LC3B2 / MP3B2
|
Transcripts
for MAP1LC3B2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MAP1LC3B2 gene: NM_001085481.1 Unigene Cluster for MAP1LC3B2: Microtubule-associated protein 1 light chain 3 beta 2 Hs.506947 [show with all ESTs]Unigene Representative Sequence: BE5310672 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000556529(uc021rej.1) ENST00000306985(uc009zwk.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP1LC3B2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP1LC3B2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MAP1LC3B2 (NM_001085481) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAP1LC3B2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP1LC3B2 |
12 DOTS entries: DT.449196 DT.100726656 DT.100704332 DT.95221181 DT.120672878 DT.120672783 DT.120672855 DT.95107000 DT.99952187 DT.120371 DT.97787551 DT.97814663
GeneLoc Exon Structure
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Expression
for MAP1LC3B2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MAP1LC3B2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See MAP1LC3B2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAP1LC3B2
SOURCE GeneReport for Unigene cluster: Hs.506947
SABiosciences Custom PCR Arrays for MAP1LC3B2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP1LC3B2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MAP1LC3B2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP1LC3B2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP1LC3B2 |
Orthologs
for MAP1LC3B2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MAP1LC3B2 gene from 7/19 species (see all 19) About this table
ENSEMBL Gene Tree for MAP1LC3B2 (if available)
TreeFam Gene Tree for MAP1LC3B2 (if available) |
Paralogs
for MAP1LC3B2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MAP1LC3B2 gene
- GABARAPL22 MAP1LC3B2 MAP1LC3C2 GABARAP2 MAP1LC3A2 GABARAPL32 GABARAPL12
8 SIMAP similar genes for MAP1LC3B2 using alignment to 1 protein entry: MP3B2_HUMAN:MAP1LC3B DKFZp762B153 MAP1LC3A MAP1LC3C GABARAPL2 GABARAPL1
GABARAP GABARAPL3
MAP1LC3B2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MAP1LC3B2
PGOHUM00000246736
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Genomic Variants
for MAP1LC3B2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MAP1LC3B2 (116997186 - 117014425 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MAP1LC3B2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP1LC3B2 |
|
Disorders
/ Diseases
for MAP1LC3B2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MAP1LC3B2 for disorders About GeneDecksing
3  diseases for MAP1LC3B2: About MalaCardslymphoblastic leukemia leukemia malaria
Export disorders for MAP1LC3B2 gene to outside databases
|
Publications
for MAP1LC3B2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MAP1LC3B2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MAP1LC3B2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Germline genomic variants associated with childhood a cute lymphoblastic leukemia. (PubMed id 19684603)1 TreviA+o L.R....Relling M.V. (2009)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for MAP1LC3B2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MAP1LC3B2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing MAP1LC3B2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MAP1LC3B2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MAP1LC3B2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MAP1LC3B2 gene:
Search GeneIP for patents involving MAP1LC3B2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MAP1LC3B2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MAP1LC3B2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP1LC3B2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAP1LC3B2 | | | OriGene Protein Over-expression Lysate for MAP1LC3B2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MAP1LC3B2 | | OriGene 3'-UTR Clone for MAP1LC3B2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAP1LC3B2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP1LC3B2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MAP1LC3B2 | | OriGene Custom Protein Services for MAP1LC3B2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAP1LC3B2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP1LC3B2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP1LC3B2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP1LC3B2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP1LC3B2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP1LC3B2 |
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 | | | | |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP1LC3B2 |
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