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Aliases for MAP1LC3B2 Gene

Aliases for MAP1LC3B2 Gene

  • Microtubule-Associated Protein 1 Light Chain 3 Beta 2 2 3
  • Microtubule-Associated Proteins 1A/1B Light Chain 3B-Like Protein 3
  • Microtubule-Associated Proteins 1A/1B Light Chain 3 Beta 2 3
  • Microtubule-Associated Proteins 1A/1B Light Chain 3B-Like 4
  • ATG8G 3

External Ids for MAP1LC3B2 Gene

Summaries for MAP1LC3B2 Gene

GeneCards Summary for MAP1LC3B2 Gene

MAP1LC3B2 (Microtubule-Associated Protein 1 Light Chain 3 Beta 2) is a Protein Coding gene. An important paralog of this gene is MAP1LC3C.

UniProtKB/Swiss-Prot for MAP1LC3B2 Gene

  • Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP1LC3B2 Gene

Genomics for MAP1LC3B2 Gene

Genomic Location for MAP1LC3B2 Gene

Start:
116,559,381 bp from pter
End:
116,576,620 bp from pter
Size:
17,240 bases
Orientation:
Plus strand

Genomic View for MAP1LC3B2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP1LC3B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP1LC3B2 Gene

Regulatory Elements for MAP1LC3B2 Gene

Proteins for MAP1LC3B2 Gene

  • Protein details for MAP1LC3B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NCE7-MP3B2_HUMAN
    Recommended name:
    Microtubule-associated proteins 1A/1B light chain 3 beta 2
    Protein Accession:
    A6NCE7
    Secondary Accessions:

    Protein attributes for MAP1LC3B2 Gene

    Size:
    125 amino acids
    Molecular mass:
    14628 Da
    Quaternary structure:
    • 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins.

neXtProt entry for MAP1LC3B2 Gene

Proteomics data for MAP1LC3B2 Gene at MOPED

Post-translational modifications for MAP1LC3B2 Gene

  • The precursor molecule is cleaved by APG4B/ATG4B to form LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form LC3-II.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys51 and Lys65

Other Protein References for MAP1LC3B2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAP1LC3B2 Gene

Domains for MAP1LC3B2 Gene

Protein Domains for MAP1LC3B2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAP1LC3B2 Gene

Graphical View of Domain Structure for InterPro Entry

A6NCE7

UniProtKB/Swiss-Prot:

MP3B2_HUMAN
Family:
  • Belongs to the ATG8 family.:
    • A6NCE7
genes like me logo Genes that share domains with MAP1LC3B2: view

No data available for Gene Families for MAP1LC3B2 Gene

Function for MAP1LC3B2 Gene

Molecular function for MAP1LC3B2 Gene

UniProtKB/Swiss-Prot Function: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).

Gene Ontology (GO) - Molecular Function for MAP1LC3B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding IBA --
genes like me logo Genes that share ontologies with MAP1LC3B2: view

miRNA for MAP1LC3B2 Gene

miRTarBase miRNAs that target MAP1LC3B2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAP1LC3B2 Gene

Localization for MAP1LC3B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP1LC3B2 Gene

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP1LC3B2 Gene COMPARTMENTS Subcellular localization image for MAP1LC3B2 gene
Compartment Confidence
vacuole 5
cytoskeleton 3
cytosol 3

Gene Ontology (GO) - Cellular Components for MAP1LC3B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IBA --
GO:0000421 autophagic vacuole membrane IBA --
GO:0005737 cytoplasm --
GO:0005829 cytosol IBA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with MAP1LC3B2: view

Pathways for MAP1LC3B2 Gene

SuperPathways for MAP1LC3B2 Gene

No Data Available

Interacting Proteins for MAP1LC3B2 Gene

Selected Interacting proteins: A6NCE7-MP3B2_HUMAN for MAP1LC3B2 Gene via I2D

Gene Ontology (GO) - Biological Process for MAP1LC3B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IBA --
GO:0000422 mitochondrion degradation IBA --
GO:0006914 autophagy --
GO:0006995 cellular response to nitrogen starvation IBA --
GO:0044804 nucleophagy IBA --
genes like me logo Genes that share ontologies with MAP1LC3B2: view

No data available for Pathways by source for MAP1LC3B2 Gene

Transcripts for MAP1LC3B2 Gene

mRNA/cDNA for MAP1LC3B2 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAP1LC3B2 Gene

Microtubule-associated protein 1 light chain 3 beta 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP1LC3B2 Gene

No ASD Table

Relevant External Links for MAP1LC3B2 Gene

GeneLoc Exon Structure for
MAP1LC3B2
ECgene alternative splicing isoforms for
MAP1LC3B2

Expression for MAP1LC3B2 Gene

mRNA expression in normal human tissues for MAP1LC3B2 Gene

mRNA differential expression in normal tissues according to GTEx for MAP1LC3B2 Gene

This gene is overexpressed in Whole Blood (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MAP1LC3B2 Gene

SOURCE GeneReport for Unigene cluster for MAP1LC3B2 Gene Hs.506947

genes like me logo Genes that share expressions with MAP1LC3B2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MAP1LC3B2 Gene

Orthologs for MAP1LC3B2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP1LC3B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP1LC3B2 35
  • 99.2 (n)
  • 97.6 (a)
MAP1LC3B2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP1LC3B2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map1lc3b 36
  • 94 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 98 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100359928 35
  • 84.68 (n)
  • 94.35 (a)
chicken
(Gallus gallus)
Aves MAP1LC3B 36
  • 95 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii map1lc3b 36
  • 93 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lgg-2 36
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG8 36
  • 33 (a)
OneToMany
Species with no ortholog for MAP1LC3B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MAP1LC3B2 Gene

ENSEMBL:
Gene Tree for MAP1LC3B2 (if available)
TreeFam:
Gene Tree for MAP1LC3B2 (if available)

Paralogs for MAP1LC3B2 Gene

Paralogs for MAP1LC3B2 Gene

Selected SIMAP similar genes for MAP1LC3B2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for MAP1LC3B2 Gene

genes like me logo Genes that share paralogs with MAP1LC3B2: view

Variants for MAP1LC3B2 Gene

Sequence variations from dbSNP and Humsavar for MAP1LC3B2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1272966 -- 116,567,478(-) gagcc(A/C)ccgtg intron-variant
rs2047953 -- 116,569,105(-) gtggg(C/T)ggatc intron-variant
rs2047954 -- 116,569,015(-) aggcg(A/T)ggtgg intron-variant
rs2047955 -- 116,569,009(-) ggtgg(C/T)gggtg intron-variant
rs2089222 -- 116,564,853(+) CTGCA(A/G)TCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP1LC3B2 Gene

Variant ID Type Subtype PubMed ID
nsv899540 CNV Gain 21882294
esv2675163 CNV Deletion 23128226
nsv528118 CNV Gain 19592680

Relevant External Links for MAP1LC3B2 Gene

HapMap Linkage Disequilibrium report
MAP1LC3B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP1LC3B2 Gene

Disorders for MAP1LC3B2 Gene

Relevant External Links for MAP1LC3B2

Genetic Association Database (GAD)
MAP1LC3B2
genes like me logo Genes that share disorders with MAP1LC3B2: view

No data available for UniProtKB/Swiss-Prot for MAP1LC3B2 Gene

Publications for MAP1LC3B2 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4
  2. Germline genomic variants associated with childhood acute lymphoblastic leukemia. (PMID: 19684603) Trevino L.R. … Relling M.V. (Nat. Genet. 2009) 3 48
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. A COFRADIC protocol to study protein ubiquitination. (PMID: 24816145) Stes E. … Gevaert K. (J. Proteome Res. 2014) 3

Products for MAP1LC3B2 Gene

Sources for MAP1LC3B2 Gene

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