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Aliases for MAP1LC3B2 Gene

Aliases for MAP1LC3B2 Gene

  • Microtubule Associated Protein 1 Light Chain 3 Beta 2 2 3 5
  • Microtubule-Associated Proteins 1A/1B Light Chain 3B-Like Protein 3
  • Microtubule-Associated Proteins 1A/1B Light Chain 3 Beta 2 3
  • Microtubule-Associated Proteins 1A/1B Light Chain 3B-Like 4
  • ATG8G 3

External Ids for MAP1LC3B2 Gene

Previous GeneCards Identifiers for MAP1LC3B2 Gene

  • GC12P115483
  • GC12P116997
  • GC12P114006

Summaries for MAP1LC3B2 Gene

GeneCards Summary for MAP1LC3B2 Gene

MAP1LC3B2 (Microtubule Associated Protein 1 Light Chain 3 Beta 2) is a Protein Coding gene. GO annotations related to this gene include microtubule binding. An important paralog of this gene is MAP1LC3B.

UniProtKB/Swiss-Prot for MAP1LC3B2 Gene

  • Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP1LC3B2 Gene

Genomics for MAP1LC3B2 Gene

Regulatory Elements for MAP1LC3B2 Gene

Enhancers for MAP1LC3B2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F116520 1.1 FANTOM5 Ensembl ENCODE 53.4 -27.0 -27039 1.7 PKNOX1 KLF17 FEZF1 SCRT2 SMARCA5 ZNF263 ZNF362 OVOL3 ZEB2 ZNF623 MAP1LC3B2 MED13L ENSG00000258018 GC12M116512
GH12F116536 0.9 FANTOM5 Ensembl ENCODE 40.9 -9.4 -9395 4.3 TBL1XR1 BMI1 RAD21 CBX5 SCRT2 ETV6 CREM ZNF362 CBFB JUNB MAP1LC3B2 MED13L LINC00173 LOC105370009 GC12P116544
GH12F116551 0.8 FANTOM5 Ensembl ENCODE 39.5 +4.2 4150 1.5 HDGF PKNOX1 ATF1 FOS NCOA1 MEF2D SMARCA4 PBX2 NBN KDM1A MAP1LC3B2 MED13L FBXW8 LINC00173 ENSG00000275898
GH12F116591 1.2 FANTOM5 Ensembl ENCODE 37.9 +45.5 45493 4.4 BCOR HDGF CTCF PKNOX1 ZMYM3 MAX YBX1 ZIC2 RAD21 ZKSCAN1 MAP1LC3B2 MED13L ENSG00000258249 ENSG00000275898
GH12F116336 1.3 FANTOM5 Ensembl ENCODE 35.3 -211.1 -211105 2.0 HDGF PKNOX1 ATF1 CREB3L1 ZNF121 ZNF366 CBX5 CREM CEBPB NCOA1 MAP1LC3B2 MED13L LOC105370005 GC12P116283
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MAP1LC3B2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAP1LC3B2 Gene

Chromosome:
12
Start:
116,548,105 bp from pter
End:
116,576,620 bp from pter
Size:
28,516 bases
Orientation:
Plus strand

Genomic View for MAP1LC3B2 Gene

Genes around MAP1LC3B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP1LC3B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP1LC3B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP1LC3B2 Gene

Proteins for MAP1LC3B2 Gene

  • Protein details for MAP1LC3B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NCE7-MP3B2_HUMAN
    Recommended name:
    Microtubule-associated proteins 1A/1B light chain 3 beta 2
    Protein Accession:
    A6NCE7

    Protein attributes for MAP1LC3B2 Gene

    Size:
    125 amino acids
    Molecular mass:
    14628 Da
    Quaternary structure:
    • 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins.

neXtProt entry for MAP1LC3B2 Gene

Post-translational modifications for MAP1LC3B2 Gene

  • The precursor molecule is cleaved by APG4B/ATG4B to form LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form LC3-II.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP1LC3B2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAP1LC3B2 Gene

Domains & Families for MAP1LC3B2 Gene

Gene Families for MAP1LC3B2 Gene

Protein Domains for MAP1LC3B2 Gene

Suggested Antigen Peptide Sequences for MAP1LC3B2 Gene

Graphical View of Domain Structure for InterPro Entry

A6NCE7

UniProtKB/Swiss-Prot:

MP3B2_HUMAN :
  • Belongs to the ATG8 family.
Family:
  • Belongs to the ATG8 family.
genes like me logo Genes that share domains with MAP1LC3B2: view

Function for MAP1LC3B2 Gene

Molecular function for MAP1LC3B2 Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity).

Gene Ontology (GO) - Molecular Function for MAP1LC3B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding IBA --
genes like me logo Genes that share ontologies with MAP1LC3B2: view

Phenotypes for MAP1LC3B2 Gene

GenomeRNAi human phenotypes for MAP1LC3B2:
genes like me logo Genes that share phenotypes with MAP1LC3B2: view

Animal Model Products

miRNA for MAP1LC3B2 Gene

miRTarBase miRNAs that target MAP1LC3B2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP1LC3B2 Gene

Localization for MAP1LC3B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP1LC3B2 Gene

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP1LC3B2 Gene COMPARTMENTS Subcellular localization image for MAP1LC3B2 gene
Compartment Confidence
cytosol 4
vacuole 4
cytoskeleton 3
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MAP1LC3B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane IBA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with MAP1LC3B2: view

Pathways & Interactions for MAP1LC3B2 Gene

SuperPathways for MAP1LC3B2 Gene

No Data Available

Interacting Proteins for MAP1LC3B2 Gene

Gene Ontology (GO) - Biological Process for MAP1LC3B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA --
GO:0000422 mitophagy IBA --
GO:0006914 autophagy IEA --
GO:0006995 cellular response to nitrogen starvation IBA --
genes like me logo Genes that share ontologies with MAP1LC3B2: view

No data available for Pathways by source and SIGNOR curated interactions for MAP1LC3B2 Gene

Transcripts for MAP1LC3B2 Gene

mRNA/cDNA for MAP1LC3B2 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAP1LC3B2 Gene

Microtubule-associated protein 1 light chain 3 beta 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP1LC3B2 Gene

No ASD Table

Relevant External Links for MAP1LC3B2 Gene

GeneLoc Exon Structure for
MAP1LC3B2
ECgene alternative splicing isoforms for
MAP1LC3B2

Expression for MAP1LC3B2 Gene

mRNA expression in normal human tissues for MAP1LC3B2 Gene

mRNA differential expression in normal tissues according to GTEx for MAP1LC3B2 Gene

This gene is overexpressed in Whole Blood (x6.1).

Protein differential expression in normal tissues from HIPED for MAP1LC3B2 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MAP1LC3B2 Gene



Protein tissue co-expression partners for MAP1LC3B2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAP1LC3B2 Gene:

MAP1LC3B2

SOURCE GeneReport for Unigene cluster for MAP1LC3B2 Gene:

Hs.506947
genes like me logo Genes that share expression patterns with MAP1LC3B2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MAP1LC3B2 Gene

Orthologs for MAP1LC3B2 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MAP1LC3B2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP1LC3B2 34
  • 99.2 (n)
rat
(Rattus norvegicus)
Mammalia LOC100359928 34
  • 84.68 (n)
Species where no ortholog for MAP1LC3B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAP1LC3B2 Gene

ENSEMBL:
Gene Tree for MAP1LC3B2 (if available)
TreeFam:
Gene Tree for MAP1LC3B2 (if available)

Paralogs for MAP1LC3B2 Gene

Paralogs for MAP1LC3B2 Gene

(8) SIMAP similar genes for MAP1LC3B2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for MAP1LC3B2 Gene

genes like me logo Genes that share paralogs with MAP1LC3B2: view

Variants for MAP1LC3B2 Gene

Sequence variations from dbSNP and Humsavar for MAP1LC3B2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10161436 -- 116,562,227(+) ATAAA(A/G)GATAG intron-variant
rs10735094 -- 116,568,047(+) TGAGT(A/G)AATGT intron-variant
rs10850664 -- 116,559,021(+) GGCAA(A/G)AAGAG upstream-variant-2KB
rs10850665 -- 116,559,390(+) GGCTC(C/G)CAGCC reference, synonymous-codon, utr-variant-5-prime
rs10850667 -- 116,569,172(+) CTTTT(C/G)TTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP1LC3B2 Gene

Variant ID Type Subtype PubMed ID
esv2675163 CNV deletion 23128226
esv3630848 CNV gain 21293372
esv3630852 CNV loss 21293372
nsv1040904 CNV gain 25217958
nsv528118 CNV gain 19592680
nsv983366 CNV duplication 23825009

Variation tolerance for MAP1LC3B2 Gene

Residual Variation Intolerance Score: 82.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.04; 60.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP1LC3B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP1LC3B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP1LC3B2 Gene

Disorders for MAP1LC3B2 Gene

Relevant External Links for MAP1LC3B2

Genetic Association Database (GAD)
MAP1LC3B2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP1LC3B2

No disorders were found for MAP1LC3B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP1LC3B2 Gene

Publications for MAP1LC3B2 Gene

  1. Germline genomic variants associated with childhood acute lymphoblastic leukemia. (PMID: 19684603) Trevino L.R. … Relling M.V. (Nat. Genet. 2009) 3 46 64
  2. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 64
  3. Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration. (PMID: 26115100) Campbell G.R. … Spector S.A. (PLoS Pathog. 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for MAP1LC3B2 Gene

Sources for MAP1LC3B2 Gene

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