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MAP1LC3B2 Gene

protein-coding   GIFtS: 42
GCID: GC12P116997

Microtubule-Associated Protein 1 Light Chain 3 Beta 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microtubule-Associated Protein 1 Light Chain 3 Beta 21 2
ATG8G2
Microtubule-Associated Proteins 1A/1B Light Chain 3 Beta 22
Microtubule-Associated Proteins 1A/1B Light Chain 3B-Like Protein2
Microtubule-Associated Proteins 1A/1B Light Chain 3B-Like3

External Ids:    HGNC: 343901   Entrez Gene: 6432462   Ensembl: ENSG000001714717   UniProtKB: A6NCE73   

Export aliases for MAP1LC3B2 gene to outside databases

Previous GC identifers: GC12P115483 GC12P114006


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MAP1LC3B2 Gene:
MAP1LC3B2 (microtubule-associated protein 1 light chain 3 beta 2) is a protein-coding gene. Diseases associated with MAP1LC3B2 include lymphoblastic leukemia, and leukemia. An important paralog of this gene is GABARAPL2.

UniProtKB/Swiss-Prot: MP3B2_HUMAN, A6NCE7
Function: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role
in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to
a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are
involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage
in autophagosome maturation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP1LC3B2 gene promoter:
         Pbx1a   GCNF   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   STAT5A   POU3F2   E47   GCNF-1   MRF-2   GCNF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MAP1LC3B2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP1LC3B2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.22   Ensembl cytogenetic band:  12q24.22   HGNC cytogenetic band: 12q24.22

MAP1LC3B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP1LC3B2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P116997:  view genomic region     (about GC identifiers)

Start:
116,997,186 bp from pter      End:
117,014,425 bp from pter
Size:
17,240 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MP3B2_HUMAN, A6NCE7 (See protein sequence)
Recommended Name: Microtubule-associated proteins 1A/1B light chain 3 beta 2 precursor  
Size: 125 amino acids; 14628 Da
Subunit: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity)

Explore the universe of human proteins at neXtProt for MAP1LC3B2: NX_A6NCE7

Explore proteomics data for MAP1LC3B2 at MOPED

Post-translational modifications: 

  • The precursor molecule is cleaved by APG4B/ATG4B to form LC3-I (By similarity). This is activated by APG7L/ATG7,
    transferred to ATG3 and conjugated to phospholipid to form LC3-II (By similarity)1
  • Ubiquitination2 at Lys51, Lys65
  • Modification sites at PhosphoSitePlus

  • See MAP1LC3B2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001078950.1  
    ENSEMBL proteins: 
     ENSP00000450524   ENSP00000305059  

    MAP1LC3B2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for MAP1LC3B2
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    Novus Biologicals MAP1LC3B2 Proteins
    Novus Biologicals MAP1LC3B2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MAP1LC3B2
    Browse Proteins at Cloud-Clone Corp.

    MAP1LC3B2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP1LC3B2
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    OriGene Custom Antibody Services for MAP1LC3B2
    Search for Antibodies for MAP1LC3B2 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for MAP1LC3B2
    Search LSBio for Antibodies for MAP1LC3B2

    MAP1LC3B2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004241 Atg8_like

    Graphical View of Domain Structure for InterPro Entry A6NCE7

    ProtoNet protein and cluster: A6NCE7

    UniProtKB/Swiss-Prot: MP3B2_HUMAN, A6NCE7
    Similarity: Belongs to the ATG8 family


    MAP1LC3B2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MP3B2_HUMAN, A6NCE7
    Function: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role
    in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to
    a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are
    involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage
    in autophagosome maturation (By similarity)

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAP1LC3B2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP1LC3B2

    miRNA
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    miRTarBase miRNAs that target MAP1LC3B2:
    hsa-mir-30a-5p (MIRT028572)

    Block miRNA regulation of human, mouse, rat MAP1LC3B2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MAP1LC3B2:
    hsa-miR-518a-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MAP1LC3B2
    Predesigned siRNA for gene silencing in human, mouse, rat MAP1LC3B2

    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP1LC3B2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MP3B2_HUMAN, A6NCE7: Cytoplasm, cytoskeleton (By similarity). Endomembrane system; Lipid-anchor (By similarity).
    Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor (By similarity). Note=LC3-II binds to the autophagic
    membranes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    vacuole5
    cytoskeleton3
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000421autophagic vacuole membrane IEA--
    GO:0005737cytoplasm ----
    GO:0005874microtubule IEA--
    GO:0012505endomembrane system IEA--
    GO:0031410cytoplasmic vesicle IEA--

    MAP1LC3B2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAP1LC3B2
    Interactions:

        Search GeneGlobe Interaction Network for MAP1LC3B2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for MAP1LC3B2 (A6NCE73 ENSP000003050594) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATG3Q9NT623, ENSP000002832904I2D: score=2 STRING: ENSP00000283290
    ATG10Q9H0Y03, ENSP000002821854I2D: score=2 STRING: ENSP00000282185
    MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=2 STRING: ENSP00000268607
    ATG12O948173I2D: score=1 
    ATG4BQ9Y4P13I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly ----
    GO:0006914autophagy IEA--

    MAP1LC3B2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAP1LC3B2 (MP3B2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAP1LC3B2 gene: 
    NM_001085481.1  

    Unigene Cluster for MAP1LC3B2:

    Microtubule-associated protein 1 light chain 3 beta 2
    Hs.506947  [show with all ESTs]
    Unigene Representative Sequence: BE531067
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556529(uc021rej.1) ENST00000306985(uc009zwk.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat MAP1LC3B2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MAP1LC3B2:
    hsa-miR-518a-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      Search QuantiTect SYBR Green Assays in human, mouse, rat MAP1LC3B2
      QuantiFast Probe-based Assays in human, mouse, rat MAP1LC3B2

    12 DOTS entries:

    DT.449196  DT.100726656  DT.100704332  DT.95221181  DT.120672878  DT.120672783  DT.120672855  DT.95107000 
    DT.99952187  DT.120371  DT.97787551  DT.97814663 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAP1LC3B2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MAP1LC3B2 Expression
    About this image

    MAP1LC3B2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP1LC3B2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.506947
        Custom PCR Arrays for MAP1LC3B2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP1LC3B2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAP1LC3B2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves MAP1LC3B6
    Gallus gallus microtubule-associated protein 1 lig...
    95(a)
    1 → many
    AADN03010474.1(6962-12372)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    74(a)
    1 → many
    GL343957.1(75975-79008)
    zebrafish
    (Danio rerio)
    Actinopterygii map1lc3b6
    microtubule-associated protein 1 light chain 3 bet...
    93(a)
    1 → many
    25(13540934-13552882) ENSDARG00000020048
    worm
    (Caenorhabditis elegans)
    Secernentea lgg-26
    Protein LGG-2, isoform a
    52(a)
    1 → many
    IV(10934191-10935903) WBGene00002981
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ATG86
    Component of autophagosomes and Cvt vesicles; unde...
    33(a)
    1 → many
    II(80378-80731) YBL078C
            Species with no ortholog for MAP1LC3B2

    ENSEMBL Gene Tree for MAP1LC3B2 (if available)
    TreeFam Gene Tree for MAP1LC3B2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP1LC3B2 gene
    GABARAPL22  MAP1LC3B2  MAP1LC3A2  GABARAP2  MAP1LC3C2  GABARAPL32  GABARAPL12  
    8 SIMAP similar genes for MAP1LC3B2 using alignment to 1 protein entry:     MP3B2_HUMAN:
    MAP1LC3B    DKFZp762B153    MAP1LC3A    MAP1LC3C    GABARAPL2    GABARAPL1
    GABARAP    GABARAPL3

    MAP1LC3B2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MAP1LC3B2
    PGOHUM00000246736


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP1LC3B2 (see all 469)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1513202221,2
    --116995314(+) CGGAAA/TAAAGA 1 -- us2k10--------
    rs748675881,2
    --116995362(+) GAAAAC/TCACAG 1 -- us2k10--------
    rs1504060791,2
    --116995519(+) TGCTTA/GTGTAA 1 -- us2k10--------
    rs1451653451,2
    C--116995638(+) ATCTCA/GGCTCA 1 -- us2k10--------
    rs591981041,2
    C--116995661(+) CCTCCC/TGGGTT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1910649071,2
    --116995900(+) GTGAGA/GCTTCC 1 -- us2k10--------
    rs1392280501,2
    --116995961(+) ACCTT-/CTATTT 1 -- us2k10--------
    rs110680721,2
    C,F--116996085(+) cacagG/Ccgtgc 1 -- us2k15Minor allele frequency- C:0.20WA NA CSA EA 245
    rs1115133931,2
    C,F--116996213(+) TACTGG/AGATTA 1 -- us2k13Minor allele frequency- A:0.12NA EA 242
    rs793656061,2
    C,F--116996268(+) CCTGGG/ACAGGT 1 -- us2k12Minor allele frequency- A:0.09CSA WA 120

    HapMap Linkage Disequilibrium report for MAP1LC3B2 (116997186 - 117014425 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MAP1LC3B2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675163CNV Deletion23128226
    nsv899540CNV Gain21882294
    nsv528118CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for MAP1LC3B2:    
    About MalaCards
    lymphoblastic leukemia    leukemia


    MAP1LC3B2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MAP1LC3B2

    Export disorders for MAP1LC3B2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP1LC3B2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with MAP1LC3B2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Germline genomic variants associated with childhood acute lymphoblastic leukemia. (PubMed id 19684603)1, 4 Trevino L.R.... Relling M.V. (Nat. Genet. 2009)
    2. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    5. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 643246 HGNC: 34390 Ensembl:ENSG00000171471 euGenes: HUgn643246 ECgene: MAP1LC3B2
    H-InvDB: MAP1LC3B2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAP1LC3B2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAP1LC3B2 gene:
    Search GeneIP for patents involving MAP1LC3B2

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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