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Aliases for MAP1LC3B Gene

Aliases for MAP1LC3B Gene

  • Microtubule Associated Protein 1 Light Chain 3 Beta 2 3 5
  • Microtubule-Associated Protein 1 Light Chain 3 Beta 3 4
  • Autophagy-Related Ubiquitin-Like Modifier LC3 B 3 4
  • MAP1 Light Chain 3-Like Protein 2 3 4
  • MAP1A/MAP1B Light Chain 3 B 3 4
  • MAP1A/MAP1B LC3 B 3 4
  • Autophagy-Related Protein LC3 B 4
  • MAP1A/1BLC3 3
  • MAP1LC3B-A 3
  • MAP1ALC3 4
  • ATG8F 3
  • LC3B 3

External Ids for MAP1LC3B Gene

Previous GeneCards Identifiers for MAP1LC3B Gene

  • GC16P078763
  • GC16P088456
  • GC16P087166
  • GC16P087206
  • GC16P087207
  • GC16P085982
  • GC16P073168

Summaries for MAP1LC3B Gene

Entrez Gene Summary for MAP1LC3B Gene

  • The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP1LC3B Gene

MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 Beta) is a Protein Coding gene. Diseases associated with MAP1LC3B include sporadic pheochromocytoma. Among its related pathways are Cellular Senescence and mTOR signalling. GO annotations related to this gene include microtubule binding. An important paralog of this gene is MAP1LC3C.

UniProtKB/Swiss-Prot for MAP1LC3B Gene

  • Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

Gene Wiki entry for MAP1LC3B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP1LC3B Gene

Genomics for MAP1LC3B Gene

Regulatory Elements for MAP1LC3B Gene

Enhancers for MAP1LC3B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAP1LC3B on UCSC Golden Path with GeneCards custom track

Promoters for MAP1LC3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAP1LC3B on UCSC Golden Path with GeneCards custom track

Genomic Location for MAP1LC3B Gene

Chromosome:
16
Start:
87,383,995 bp from pter
End:
87,404,779 bp from pter
Size:
20,785 bases
Orientation:
Plus strand

Genomic View for MAP1LC3B Gene

Genes around MAP1LC3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP1LC3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP1LC3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP1LC3B Gene

Proteins for MAP1LC3B Gene

  • Protein details for MAP1LC3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZQ8-MLP3B_HUMAN
    Recommended name:
    Microtubule-associated proteins 1A/1B light chain 3B
    Protein Accession:
    Q9GZQ8
    Secondary Accessions:
    • Q6NW02

    Protein attributes for MAP1LC3B Gene

    Size:
    125 amino acids
    Molecular mass:
    14688 Da
    Quaternary structure:
    • 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts at microtubules with CABP1 (via EF-hands 1 and 2) but not with calmodulin. Interacts with FYCO1 (via C-terminus). Interacts with TP53INP1 and TP53INP2. Interacts with TBC1D25. Directly interacts with SQSTM1; this interaction leads to MAP1LC3B recruitment to inclusion bodies containing polyubiquitinated protein aggregates and to inclusion body degradation by autophagy. Interacts with ATG4B, MAPK15 and BNIP3. Interacts with MAPB1, KEAP1, PCM1, OFD1, CEP131, and TECPR2. Interacts with TBC1D5 (PubMed:22354992). Found in a complex with UBQLN1 and UBQLN2. Interacts with UBQLN4 (via STI1 1 and 2 domains). Interacts with UBQLN1 in the presence of UBQLN4.

    Three dimensional structures from OCA and Proteopedia for MAP1LC3B Gene

neXtProt entry for MAP1LC3B Gene

Proteomics data for MAP1LC3B Gene at MOPED

Post-translational modifications for MAP1LC3B Gene

  • Phosphorylation at Thr-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE) (By similarity). Interaction with MAPK15 reduces the inhibitory phosphorylation and increases autophagy activity.
  • The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.
  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II (PubMed:15187094).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP1LC3B Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAP1LC3B (LC3B)

No data available for DME Specific Peptides for MAP1LC3B Gene

Domains & Families for MAP1LC3B Gene

Gene Families for MAP1LC3B Gene

Protein Domains for MAP1LC3B Gene

Suggested Antigen Peptide Sequences for MAP1LC3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZQ8

UniProtKB/Swiss-Prot:

MLP3B_HUMAN :
  • Belongs to the ATG8 family.
Family:
  • Belongs to the ATG8 family.
genes like me logo Genes that share domains with MAP1LC3B: view

Function for MAP1LC3B Gene

Molecular function for MAP1LC3B Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
genes like me logo Genes that share phenotypes with MAP1LC3B: view

Animal Models for MAP1LC3B Gene

MGI Knock Outs for MAP1LC3B:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP1LC3B Gene

Localization for MAP1LC3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP1LC3B Gene

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome. Note=LC3-II binds to the autophagic membranes. Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP1LC3B Gene COMPARTMENTS Subcellular localization image for MAP1LC3B gene
Compartment Confidence
cytosol 5
mitochondrion 5
vacuole 5
cytoskeleton 4
lysosome 3
endoplasmic reticulum 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MAP1LC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane TAS --
GO:0005776 autophagosome ISS 12740394
GO:0005829 cytosol TAS --
GO:0005874 microtubule IEA --
GO:0005930 axoneme ISS --
genes like me logo Genes that share ontologies with MAP1LC3B: view

Pathways & Interactions for MAP1LC3B Gene

genes like me logo Genes that share pathways with MAP1LC3B: view

Pathways by source for MAP1LC3B Gene

1 GeneTex pathway for MAP1LC3B Gene
1 BioSystems pathway for MAP1LC3B Gene

SIGNOR curated interactions for MAP1LC3B Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for MAP1LC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000422 mitophagy IBA --
GO:1903146 regulation of mitophagy IGI 19279012
genes like me logo Genes that share ontologies with MAP1LC3B: view

Drugs & Compounds for MAP1LC3B Gene

(4) Drugs for MAP1LC3B Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1859
2-Methoxyestradiol (2-MeOE2) Pharma Apoptotic, antiproliferative and antiangiogenic agent 0
Epothilone B (EPO906, Patupilone) Pharma Microtubule stabilizing macrolide 0
Vinorelbine ditartrate Pharma Anti-mitotic chemotherapy drug, Tubulin inhibitor 0

(4) ApexBio Compounds for MAP1LC3B Gene

Compound Action Cas Number
2-Methoxyestradiol (2-MeOE2) Apoptotic, antiproliferative and antiangiogenic agent 362-07-2
Docetaxel Microtubulin disassembly inhibitor 114977-28-5
Epothilone B (EPO906, Patupilone) Microtubule stabilizing macrolide 152044-54-7
Vinorelbine ditartrate Anti-mitotic chemotherapy drug 125317-39-7
genes like me logo Genes that share compounds with MAP1LC3B: view

Transcripts for MAP1LC3B Gene

Unigene Clusters for MAP1LC3B Gene

Microtubule-associated protein 1 light chain 3 beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP1LC3B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2:

Relevant External Links for MAP1LC3B Gene

GeneLoc Exon Structure for
MAP1LC3B
ECgene alternative splicing isoforms for
MAP1LC3B

Expression for MAP1LC3B Gene

mRNA expression in normal human tissues for MAP1LC3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAP1LC3B Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAP1LC3B Gene



SOURCE GeneReport for Unigene cluster for MAP1LC3B Gene Hs.356061

mRNA Expression by UniProt/SwissProt for MAP1LC3B Gene

Q9GZQ8-MLP3B_HUMAN
Tissue specificity: Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver.
genes like me logo Genes that share expression patterns with MAP1LC3B: view

Protein tissue co-expression partners for MAP1LC3B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MAP1LC3B Gene

Orthologs for MAP1LC3B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP1LC3B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAP1LC3B 35
  • 89.33 (n)
  • 99.2 (a)
MAP1LC3B 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP1LC3B 35
  • 90.67 (n)
  • 99.2 (a)
mouse
(Mus musculus)
Mammalia Map1lc3b 35
  • 84.8 (n)
  • 95.2 (a)
Map1lc3b 16
Gm5612 36
  • 80 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia MAP1LC3B 35
  • 99.73 (n)
  • 100 (a)
MAP1LC3B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map1lc3b 35
  • 85.87 (n)
  • 96 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 98 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToMany
chicken
(Gallus gallus)
Aves MAP1LC3B 35
  • 83.47 (n)
  • 95.2 (a)
MAP1LC3B 36
  • 96 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia map1lc3b 35
  • 77.15 (n)
  • 94.35 (a)
MGC76283 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68744 35
zebrafish
(Danio rerio)
Actinopterygii map1lc3b 35
  • 74.59 (n)
  • 93.44 (a)
wufb60g11 35
map1lc3b 36
  • 93 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10143 35
worm
(Caenorhabditis elegans)
Secernentea lgg-2 36
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG8 36
  • 34 (a)
OneToMany
Species with no ortholog for MAP1LC3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP1LC3B Gene

ENSEMBL:
Gene Tree for MAP1LC3B (if available)
TreeFam:
Gene Tree for MAP1LC3B (if available)

Paralogs for MAP1LC3B Gene

Paralogs for MAP1LC3B Gene

genes like me logo Genes that share paralogs with MAP1LC3B: view

Variants for MAP1LC3B Gene

Sequence variations from dbSNP and Humsavar for MAP1LC3B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs7865 -- 87,403,202(+) ATCAT(C/G/T)AAACA utr-variant-3-prime
rs9903 -- 87,403,501(-) AAAGG(C/T)GGCGG utr-variant-3-prime
rs34419 -- 87,401,047(-) caagc(A/G)attct intron-variant
rs40068 -- 87,401,112(-) tctgt(C/T)gccca intron-variant
rs40069 -- 87,400,979(-) atttt(G/T)gtatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP1LC3B Gene

Variant ID Type Subtype PubMed ID
nsv907153 CNV Loss 21882294
nsv510694 CNV Loss 20534489
nsv907156 CNV Loss 21882294
nsv833320 CNV Gain 17160897
nsv428330 CNV Gain 18775914
dgv499n67 CNV Gain 20364138
dgv2950n71 CNV Loss 21882294

Variation tolerance for MAP1LC3B Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP1LC3B Gene

HapMap Linkage Disequilibrium report
MAP1LC3B
Human Gene Mutation Database (HGMD)
MAP1LC3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP1LC3B Gene

Disorders for MAP1LC3B Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAP1LC3B Gene - From: GeneCards

Disorder Aliases PubMed IDs
sporadic pheochromocytoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAP1LC3B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP1LC3B
genes like me logo Genes that share disorders with MAP1LC3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP1LC3B Gene

Publications for MAP1LC3B Gene

  1. Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes. (PMID: 15355958) Tanida I. … Kominami E. (J. Biol. Chem. 2004) 3 4 23 67
  2. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. (PMID: 20038797) Rouschop K.M. … Wouters B.G. (J. Clin. Invest. 2010) 3 23
  3. AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1. (PMID: 25215947) Strappazzon F. … Cecconi F. (Cell Death Differ. 2015) 3
  4. Autophagy restricts HIV-1 infection by selectively degrading Tat in CD4+ T lymphocytes. (PMID: 25339774) Sagnier S. … Espert L. (J. Virol. 2015) 3
  5. Reviving an old HIV-1 gene: the HIV-1 antisense protein. (PMID: 25439234) Torresilla C. … Barbeau B. (Curr. HIV Res. 2015) 3

Products for MAP1LC3B Gene

Sources for MAP1LC3B Gene

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