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Aliases for MAP1LC3B Gene

Aliases for MAP1LC3B Gene

  • Microtubule Associated Protein 1 Light Chain 3 Beta 2 3 5
  • Autophagy-Related Ubiquitin-Like Modifier LC3 B 3 4
  • MAP1 Light Chain 3-Like Protein 2 3 4
  • MAP1A/MAP1B Light Chain 3 B 3 4
  • MAP1A/MAP1B LC3 B 3 4
  • Microtubule-Associated Proteins 1A/1B Light Chain 3B 3
  • Microtubule-Associated Protein 1 Light Chain 3 Beta 4
  • Autophagy-Related Protein LC3 B 4
  • MAP1A/1BLC3 3
  • MAP1LC3B-A 3
  • MAP1ALC3 4
  • ATG8F 3
  • LC3B 3

External Ids for MAP1LC3B Gene

Previous GeneCards Identifiers for MAP1LC3B Gene

  • GC16P078763
  • GC16P088456
  • GC16P087166
  • GC16P087206
  • GC16P087207
  • GC16P085982
  • GC16P073168

Summaries for MAP1LC3B Gene

Entrez Gene Summary for MAP1LC3B Gene

  • The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP1LC3B Gene

MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 Beta) is a Protein Coding gene. Diseases associated with MAP1LC3B include Sporadic Pheochromocytoma and Lacrimal Gland Adenocarcinoma. Among its related pathways are Vesicle-mediated transport and Senescence and Autophagy in Cancer. GO annotations related to this gene include microtubule binding. An important paralog of this gene is MAP1LC3B2.

UniProtKB/Swiss-Prot for MAP1LC3B Gene

  • Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

Gene Wiki entry for MAP1LC3B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP1LC3B Gene

Genomics for MAP1LC3B Gene

Regulatory Elements for MAP1LC3B Gene

Enhancers for MAP1LC3B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G087459 2 FANTOM5 Ensembl ENCODE dbSUPER 7.1 +79.7 79675 7.9 HDGF FOXA2 PKNOX1 CREB3L1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 KLHDC4 ZCCHC14 MAP1LC3B FBXO31 BANP NR3C1P1 ENSG00000261592
GH16G087469 1.4 Ensembl ENCODE dbSUPER 5.4 +87.1 87118 3.2 ELF3 ZSCAN4 ARID4B DMAP1 RARA YY1 ZNF121 SCRT2 MIXL1 THAP11 KLHDC4 ZCCHC14 MAP1LC3B NR3C1P1 ENSG00000276337
GH16G087841 2.1 FANTOM5 Ensembl ENCODE dbSUPER 3.1 +468.5 468499 22.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 BANP SLC7A5 FBXO31 LOC400553 ZCCHC14 APRT MAP1LC3B CA5A KLHDC4 PIR45032
GH16G087864 1.8 FANTOM5 ENCODE dbSUPER 1.8 +485.4 485374 8.8 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A FEZF1 KLHDC4 CTU2 TRAPPC2L CA5A BANP ZCCHC14 MAP1LC3B FBXO31 SLC7A5 PIR45032
GH16G087576 0.4 ENCODE 5.7 +192.4 192415 0.2 ZNF610 EGR1 JPH3 KLHDC4 MAP1LC3B PIR35253
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAP1LC3B on UCSC Golden Path with GeneCards custom track

Promoters for MAP1LC3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000089312 -395 2401 MLX AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A

Genomic Location for MAP1LC3B Gene

Chromosome:
16
Start:
87,383,995 bp from pter
End:
87,404,779 bp from pter
Size:
20,785 bases
Orientation:
Plus strand

Genomic View for MAP1LC3B Gene

Genes around MAP1LC3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP1LC3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP1LC3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP1LC3B Gene

Proteins for MAP1LC3B Gene

  • Protein details for MAP1LC3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZQ8-MLP3B_HUMAN
    Recommended name:
    Microtubule-associated proteins 1A/1B light chain 3B
    Protein Accession:
    Q9GZQ8
    Secondary Accessions:
    • Q6NW02

    Protein attributes for MAP1LC3B Gene

    Size:
    125 amino acids
    Molecular mass:
    14688 Da
    Quaternary structure:
    • 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts at microtubules with CABP1 (via EF-hands 1 and 2) but not with calmodulin (PubMed:15095872). Interacts with FYCO1 (via C-terminus) (PubMed:20100911, PubMed:24089205). Interacts with TP53INP1 and TP53INP2 (PubMed:22470510). Interacts with TBC1D25 (PubMed:21383079). Directly interacts with SQSTM1; this interaction leads to MAP1LC3B recruitment to inclusion bodies containing polyubiquitinated protein aggregates and to inclusion body degradation by autophagy (PubMed:17580304, PubMed:24089205, PubMed:18524774). Interacts with ATG4B, MAPK15 and BNIP3 (PubMed:22948227, PubMed:23209295). Interacts with MAPB1, KEAP1, PCM1, OFD1, CEP131, and TECPR2 (PubMed:20562859, PubMed:24089205). Interacts with TBC1D5 (PubMed:22354992). Found in a complex with UBQLN1 and UBQLN2 (PubMed:20529957). Interacts with UBQLN4 (via STI1 1 and 2 domains). Interacts with UBQLN1 in the presence of UBQLN4 (PubMed:23459205). Interacts with ATG13 (PubMed:24290141). Interacts with FAM134A, FAM134B and FAM134C (PubMed:26040720).

    Three dimensional structures from OCA and Proteopedia for MAP1LC3B Gene

neXtProt entry for MAP1LC3B Gene

Post-translational modifications for MAP1LC3B Gene

  • Phosphorylation at Thr-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE) (By similarity). Interaction with MAPK15 reduces the inhibitory phosphorylation and increases autophagy activity.
  • The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.
  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II (PubMed:15187094).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP1LC3B Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAP1LC3B (LC3B)

No data available for DME Specific Peptides for MAP1LC3B Gene

Domains & Families for MAP1LC3B Gene

Gene Families for MAP1LC3B Gene

Protein Domains for MAP1LC3B Gene

Suggested Antigen Peptide Sequences for MAP1LC3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZQ8

UniProtKB/Swiss-Prot:

MLP3B_HUMAN :
  • Belongs to the ATG8 family.
Family:
  • Belongs to the ATG8 family.
genes like me logo Genes that share domains with MAP1LC3B: view

Function for MAP1LC3B Gene

Molecular function for MAP1LC3B Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

Gene Ontology (GO) - Molecular Function for MAP1LC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15187094
GO:0031625 ubiquitin protein ligase binding IPI 25127057
genes like me logo Genes that share ontologies with MAP1LC3B: view
genes like me logo Genes that share phenotypes with MAP1LC3B: view

Animal Models for MAP1LC3B Gene

MGI Knock Outs for MAP1LC3B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP1LC3B Gene

Localization for MAP1LC3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP1LC3B Gene

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome. Note=LC3-II binds to the autophagic membranes. Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP1LC3B gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
cytosol 5
nucleus 3
lysosome 3
endoplasmic reticulum 2
plasma membrane 1
extracellular 1
endosome 1

Gene Ontology (GO) - Cellular Components for MAP1LC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane TAS --
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IDA 25215947
GO:0005776 autophagosome ISS 12740394
genes like me logo Genes that share ontologies with MAP1LC3B: view

Pathways & Interactions for MAP1LC3B Gene

genes like me logo Genes that share pathways with MAP1LC3B: view

Pathways by source for MAP1LC3B Gene

1 GeneTex pathway for MAP1LC3B Gene
1 BioSystems pathway for MAP1LC3B Gene
1 KEGG pathway for MAP1LC3B Gene

SIGNOR curated interactions for MAP1LC3B Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for MAP1LC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000422 mitophagy IGI 19279012
GO:0006914 autophagy IEA,IDA 23629966
GO:0016236 macroautophagy TAS --
GO:0061024 membrane organization TAS --
GO:0097352 autophagosome maturation TAS --
genes like me logo Genes that share ontologies with MAP1LC3B: view

Drugs & Compounds for MAP1LC3B Gene

(4) Drugs for MAP1LC3B Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1967
2-Methoxyestradiol (2-MeOE2) Pharma Apoptotic, antiproliferative and antiangiogenic agent 0
Epothilone B (EPO906, Patupilone) Pharma Microtubule stabilizing macrolide 0
Vinorelbine ditartrate Pharma Anti-mitotic chemotherapy drug, Tubulin inhibitor 0

(4) ApexBio Compounds for MAP1LC3B Gene

Compound Action Cas Number
2-Methoxyestradiol (2-MeOE2) Apoptotic, antiproliferative and antiangiogenic agent 362-07-2
Docetaxel Microtubulin disassembly inhibitor 114977-28-5
Epothilone B (EPO906, Patupilone) Microtubule stabilizing macrolide 152044-54-7
Vinorelbine ditartrate Anti-mitotic chemotherapy drug 125317-39-7
genes like me logo Genes that share compounds with MAP1LC3B: view

Drug Products

Transcripts for MAP1LC3B Gene

Unigene Clusters for MAP1LC3B Gene

Microtubule-associated protein 1 light chain 3 beta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP1LC3B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2:

Relevant External Links for MAP1LC3B Gene

GeneLoc Exon Structure for
MAP1LC3B
ECgene alternative splicing isoforms for
MAP1LC3B

Expression for MAP1LC3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP1LC3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAP1LC3B Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAP1LC3B Gene



Protein tissue co-expression partners for MAP1LC3B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAP1LC3B Gene:

MAP1LC3B

SOURCE GeneReport for Unigene cluster for MAP1LC3B Gene:

Hs.356061

mRNA Expression by UniProt/SwissProt for MAP1LC3B Gene:

Q9GZQ8-MLP3B_HUMAN
Tissue specificity: Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver.

Evidence on tissue expression from TISSUES for MAP1LC3B Gene

  • Nervous system(5)
  • Pancreas(4.5)
  • Lung(3.6)
  • Kidney(3.5)
  • Skin(3.4)
  • Heart(3.3)
  • Eye(3)
  • Intestine(2.9)
  • Muscle(2.9)
  • Blood(2.5)
  • Bone marrow(2.2)
  • Liver(2.2)
genes like me logo Genes that share expression patterns with MAP1LC3B: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP1LC3B Gene

Orthologs for MAP1LC3B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP1LC3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP1LC3B 34 35
  • 99.73 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MAP1LC3B 34
  • 90.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 90 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MAP1LC3B 34 35
  • 89.33 (n)
rat
(Rattus norvegicus)
Mammalia Map1lc3b 34
  • 85.87 (n)
mouse
(Mus musculus)
Mammalia Map1lc3b 34 16
  • 84.8 (n)
Gm5612 35
  • 80 (a)
ManyToMany
chicken
(Gallus gallus)
Aves MAP1LC3B 34 35
  • 83.47 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 74 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia map1lc3b 34
  • 77.15 (n)
MGC76283 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68744 34
zebrafish
(Danio rerio)
Actinopterygii map1lc3b 34 35
  • 74.59 (n)
wufb60g11 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10143 34
worm
(Caenorhabditis elegans)
Secernentea lgg-2 35
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG8 35
  • 34 (a)
OneToMany
Species where no ortholog for MAP1LC3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP1LC3B Gene

ENSEMBL:
Gene Tree for MAP1LC3B (if available)
TreeFam:
Gene Tree for MAP1LC3B (if available)

Paralogs for MAP1LC3B Gene

Variants for MAP1LC3B Gene

Sequence variations from dbSNP and Humsavar for MAP1LC3B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000188528 -- 87,399,698(+) TAACA(C/G)CTTAA intron-variant
rs1000297222 -- 87,394,932(+) CAAAT(-/A)AAGAG intron-variant
rs1000355520 -- 87,391,323(+) AAAGA(A/C/G)TCTAG intron-variant, upstream-variant-2KB
rs1000551172 -- 87,394,502(+) CTCTA(C/G)CAGGA intron-variant
rs1000974116 -- 87,390,787(+) GGACG(A/G)GGTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAP1LC3B Gene

Variant ID Type Subtype PubMed ID
dgv499n67 CNV gain 20364138
nsv1131120 CNV deletion 24896259
nsv428330 CNV gain 18775914
nsv510694 CNV deletion 20534489
nsv833320 CNV gain 17160897
nsv978173 CNV duplication 23825009

Variation tolerance for MAP1LC3B Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP1LC3B Gene

Human Gene Mutation Database (HGMD)
MAP1LC3B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP1LC3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP1LC3B Gene

Disorders for MAP1LC3B Gene

MalaCards: The human disease database

(3) MalaCards diseases for MAP1LC3B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
sporadic pheochromocytoma
lacrimal gland adenocarcinoma
  • adenocarcinoma of lacrimal gland
spastic paraplegia 49, autosomal recessive
  • hereditary spastic paraplegia 49
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAP1LC3B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP1LC3B
genes like me logo Genes that share disorders with MAP1LC3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP1LC3B Gene

Publications for MAP1LC3B Gene

  1. Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes. (PMID: 15355958) Tanida I. … Kominami E. (J. Biol. Chem. 2004) 3 4 22 64
  2. Regulation of endoplasmic reticulum turnover by selective autophagy. (PMID: 26040720) Khaminets A. … Dikic I. (Nature 2015) 3 4 64
  3. Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery. (PMID: 23459205) Lee D.Y. … Brown E.J. (EMBO Rep. 2013) 3 4 64
  4. Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites. (PMID: 24089205) Tang Z. … Zhong Q. (Nature 2013) 3 4 64
  5. Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis. (PMID: 23209295) Zhu Y. … Brady N.R. (J. Biol. Chem. 2013) 3 4 64

Products for MAP1LC3B Gene

Sources for MAP1LC3B Gene

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