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MAP1LC3B Gene

protein-coding   GIFtS: 58
GCID: GC16P087425

Microtubule-Associated Protein 1 Light Chain 3 Beta

  See MAP1LC3B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microtubule-Associated Protein 1 Light Chain 3 Beta1 2 3     ATG8F2
Autophagy-Related Ubiquitin-Like Modifier LC3 B2 3     MAP1A/1BLC32
MAP1 Light Chain 3-Like Protein 22 3     MAP1LC3B-a2
MAP1A/MAP1B LC3 B2 3     Microtubule-Associated Proteins 1A/1B Light Chain 3B2
MAP1A/MAP1B Light Chain 3 B2 3     MAP1ALC33
LC3B2 5     Autophagy-Related Protein LC3 B3

External Ids:    HGNC: 133521   Entrez Gene: 816312   Ensembl: ENSG000001409417   OMIM: 6096045   UniProtKB: Q9GZQ83   

Export aliases for MAP1LC3B gene to outside databases

Previous GC identifers: GC16P078763 GC16P088456 GC16P087166 GC16P087206 GC16P087207 GC16P085982 GC16P073168


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP1LC3B Gene:
The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are
involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for
this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. (provided by
RefSeq, Jul 2008)

GeneCards Summary for MAP1LC3B Gene:
MAP1LC3B (microtubule-associated protein 1 light chain 3 beta) is a protein-coding gene. Diseases associated with MAP1LC3B include sporadic pheochromocytoma. An important paralog of this gene is GABARAPL2.

UniProtKB/Swiss-Prot: MLP3B_HUMAN, Q9GZQ8
Function: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role
in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to
a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are
involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage
in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the
autophagic pathway

Gene Wiki entry for MAP1LC3B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP1LC3B gene promoter:
         AhR   RP58   Pax-2   Pax-2a   Arnt   C/EBPalpha   AREB6   MEF-2A   aMEF-2   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAP1LC3B promoter sequence
   Search Chromatin IP Primers for MAP1LC3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP1LC3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.2   Ensembl cytogenetic band:  16q24.2   HGNC cytogenetic band: 16q24.2

MAP1LC3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP1LC3B gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P087425:  view genomic region     (about GC identifiers)

Start:
87,417,601 bp from pter      End:
87,438,385 bp from pter
Size:
20,785 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: MLP3B_HUMAN, Q9GZQ8 (See protein sequence)
Recommended Name: Microtubule-associated proteins 1A/1B light chain 3B precursor  
Size: 125 amino acids; 14688 Da
Subunit: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity).
Interacts at microtubules with CABP1 (via EF-hands 1 and 2) but not with calmodulin. Interacts with FYCO1 (via
C-terminus). Interacts with TP53INP1 and TP53INP2. Interacts with TBC1D25. Directly interacts with SQSTM1; this
interaction leads to MAP1LC3B recruitment to inclusion bodies containing polyubiquitinated protein aggregates and
to inclusion body degradation by autophagy. Interacts with ATG4B, MAPK15 and BNIP3. Interacts with MAPB1, KEAP1,
PCM1, OFD1, AZI1, and TECPR2
Caution: PubMed:12740394 has shown that the protein is cleaved at Lys-122 but PubMed:15355958 has shown that the
cleavage site is at Gly-120 as in other mammalian orthologs
Selected PDB 3D structures from and Proteopedia for MAP1LC3B (see all 7):
1V49 (3D)        2LUE (3D)        2ZJD (3D)        3VTU (3D)        3VTV (3D)        3VTW (3D)    
Secondary accessions: Q6NW02

Explore the universe of human proteins at neXtProt for MAP1LC3B: NX_Q9GZQ8

Explore proteomics data for MAP1LC3B at MOPED

Post-translational modifications: 

  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7,
    transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II1
  • The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to
    reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine1
  • Phosphorylation at Thr-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE) (By similarity).
    Interaction with MAPK15 reduces the inhibitory phosphorylation and increases autophagy activity1
  • Ubiquitination2 at Lys51, Lys65
  • Modification sites at PhosphoSitePlus

  • See MAP1LC3B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_073729.1  
    ENSEMBL proteins: 
     ENSP00000268607   ENSP00000457141   ENSP00000457225   ENSP00000454293   ENSP00000441125  

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    Browse Proteins at Cloud-Clone Corp.

     
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    Abcam antibodies for MAP1LC3B (Q9H492, Q9GZQ8)
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004241 Atg8_like

    Graphical View of Domain Structure for InterPro Entry Q9GZQ8

    ProtoNet protein and cluster: Q9GZQ8

    1 Blocks protein domain: IPB004241 Light chain 3 (LC3)

    UniProtKB/Swiss-Prot: MLP3B_HUMAN, Q9GZQ8
    Similarity: Belongs to the ATG8 family


    Find genes that share domains with MAP1LC3B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MLP3B_HUMAN, Q9GZQ8
    Function: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role
    in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to
    a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are
    involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage
    in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the
    autophagic pathway

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15187094
         
    Find genes that share ontologies with MAP1LC3B           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Map1lc3b):
     normal 

    Find genes that share phenotypes with MAP1LC3B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Map1lc3btm1Mrab for MAP1LC3B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAP1LC3B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP1LC3B
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    miRNA
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    miRTarBase miRNAs that target MAP1LC3B:
    hsa-mir-30a-5p (MIRT028590), hsa-mir-192-5p (MIRT026738), hsa-mir-215-5p (MIRT024923), hsa-mir-335-5p (MIRT018460), hsa-mir-204-5p (MIRT006449)

    Block miRNA regulation of human, mouse, rat MAP1LC3B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP1LC3B (see all 17):
    hsa-miR-320a hsa-miR-600 hsa-miR-4328 hsa-miR-188-5p hsa-miR-196a* hsa-miR-320d hsa-miR-3653 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidMAP1LC3B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MAP1LC3B

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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP1LC3B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP1LC3B
    Addgene plasmids for MAP1LC3B 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP1LC3B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MLP3B_HUMAN, Q9GZQ8: Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle,
    autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes. Localizes also to discrete
    punctae along the ciliary axoneme (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    vacuole5
    cytosol3
    endoplasmic reticulum2
    lysosome2
    mitochondrion2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000421autophagic vacuole membrane IEA--
    GO:0005622intracellular IDA--
    GO:0005737cytoplasm ----
    GO:0005776autophagic vacuole ISS12740394
    GO:0005874microtubule IEA--

    Find genes that share ontologies with MAP1LC3B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP1LC3B About    
    See pathways by source

    SuperPathContained pathways About
    1Senescence and Autophagy
    Senescence and Autophagy


    1 BioSystems Pathway for MAP1LC3B
        Senescence and Autophagy



        Pathway & Disease-focused RT2 Profiler PCR Array including MAP1LC3B: 
              Autophagy in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MAP1LC3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAP1LC3B (Q9GZQ81, 2, 3 ENSP000002686074) via UniProtKB, MINT, STRING, and/or I2D (see all 517)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly ----
    GO:0006914autophagy IEA--

    Find genes that share ontologies with MAP1LC3B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAP1LC3B (MLP3B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAP1LC3B gene: 
    NM_022818.4  

    Unigene Cluster for MAP1LC3B:

    Microtubule-associated protein 1 light chain 3 beta
    Hs.356061  [show with all ESTs]
    Unigene Representative Sequence: BC041874
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000561823 ENST00000562778 ENST00000599768 ENST00000563720 ENST00000268607(uc002fjx.3 uc010chs.3)
    ENST00000570189 ENST00000565788 ENST00000564844 ENST00000564638 ENST00000534986

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MAP1LC3B (see all 17):
    hsa-miR-320a hsa-miR-600 hsa-miR-4328 hsa-miR-188-5p hsa-miR-196a* hsa-miR-320d hsa-miR-3653 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidMAP1LC3B 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: MAP1LC3B (NM_022818)
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      QuantiTect SYBR Green Assays in human, mouse, rat MAP1LC3B
      QuantiFast Probe-based Assays in human, mouse, rat MAP1LC3B

    Additional mRNA sequence: 

    AF087871.1 AF183417.1 AF303888.1 AK024571.1 AK025556.1 AK290956.1 AK310224.1 AK310335.1 
    AL834298.1 BC018634.2 BC041874.1 BC045759.1 BC048009.1 BC067797.1 JN663879.1 

    21 DOTS entries:

    DT.95221181  DT.100704332  DT.449196  DT.100726656  DT.120672878  DT.91993419  DT.91771666  DT.120672783 
    DT.120672855  DT.120672788  DT.100828078  DT.120371  DT.100828076  DT.120672874  DT.99952187  DT.120672807 
    DT.120672842  DT.120672896  DT.95154591  DT.99971773  DT.95107000 

    Selected AceView cDNA sequences (see all 601):

    BU620381 R80142 BU616799 BU675477 AW778768 CR601539 AA904000 AA808234 
    BU783930 AA322731 AI554383 AI570415 BQ773028 CA306495 CR614938 CR611354 
    AA480305 AI298160 F03326 F10658 CR591139 BM693321 BX397339 CA309688 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MAP1LC3B    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for MAP1LC3B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAP1LC3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGTGGTCA
    MAP1LC3B Expression
    About this image


    MAP1LC3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Adipose (Muscoskeletal System)
    MAP1LC3B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP1LC3B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.356061

    UniProtKB/Swiss-Prot: MLP3B_HUMAN, Q9GZQ8
    Tissue specificity: Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver

        Pathway & Disease-focused RT2 Profiler PCR Array including MAP1LC3B: 
              Autophagy in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat MAP1LC3B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP1LC3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAP1LC3B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map1lc3b1 , 5 microtubule-associated protein 1 light chain 3 beta1, 5 84.8(n)1
    95.2(a)1
      8 (70.67 cM)5
    674431  NM_026160.41  NP_080436.11 
     1215903615 
    chicken
    (Gallus gallus)
    Aves MAP1LC3B1 microtubule-associated protein 1 light chain 3 beta 83.47(n)
    95.2(a)
      427559  NM_001031461.1  NP_001026632.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    74(a)
    1 → many
    GL343957.1(75975-79008)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687442 hypothetical protein MGC68744 79.78(n)    BC060359.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb60g112 wufb60g11 76.22(n)   322425  BC049313.1 
    worm
    (Caenorhabditis elegans)
    Secernentea lgg-26
    Protein LGG-2, isoform a
    52(a)
    1 → many
    IV(10934191-10935903) WBGene00002981
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ATG86
    Component of autophagosomes and Cvt vesicles; unde...
    34(a)
    1 → many
    II(80378-80731) YBL078C


    ENSEMBL Gene Tree for MAP1LC3B (if available)
    TreeFam Gene Tree for MAP1LC3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP1LC3B gene
    GABARAPL22  MAP1LC3A2  GABARAP2  MAP1LC3C2  GABARAPL32  MAP1LC3B22  GABARAPL12  
    8 SIMAP similar genes for MAP1LC3B using alignment to 6 protein entries:     MLP3B_HUMAN (see all proteins):
    DKFZp762B153    MAP1LC3B2    MAP1LC3A    MAP1LC3C    GABARAPL2    GABARAPL3
    GABARAP    GABARAPL1

    Find genes that share paralogs with MAP1LC3B           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for MAP1LC3B (see all 9)
    PGOHUM00000239518 PGOHUM00000239883 PGOHUM00000239936 PGOHUM00000235068 PGOHUM00000244369


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP1LC3B (see all 396)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114036971,2
    C--87427885(+) AAAAAA/-TCTTT 1 -- int1 trp32Minor allele frequency- -:0.00NA CSA 4
    rs1120262161,2
    C,F--87429747(+) CGAGCG/ATGAGC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs732386581,2
    C,F--87430578(+) ACAGGC/TGCCGG 1 -- int12Minor allele frequency- T:0.02WA 120
    rs346444411,2
    C--87433738(+) TGTGT-/GTATAAA 1 -- int11Minor allele frequency- GT:0.00NA 2
    rs1135512351,2
    C--87433786(+) TAAAA-/TTTTTT 1 -- int11Minor allele frequency- T:0.00CSA 2
    rs105438841,2
    C--87434739(+) gtctc-/A/AA  
            
    aaaaa
    1 -- int11NA 2
    rs28737021,2
    C,F,H--87436760(+) AAAAAA/GGGGAT 1 -- ut31 trp34Minor allele frequency- G:0.03NS NA 276
    rs611434111,2
    C--87437995(+) CTGTA-/TACGTTA 1 -- ut310--------
    rs1443305551,2
    --88426540(+) GTGCAA/CGGCTC 1 -- us2k10--------
    rs1875636261,2
    --88426791(+) GCTGCA/CACCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAP1LC3B (87417601 - 87438385 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MAP1LC3B:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2950n71CNV Loss21882294
    nsv907156CNV Loss21882294
    nsv510694CNV Loss20534489
    nsv907153CNV Loss21882294
    dgv499n67CNV Gain20364138
    nsv833320CNV Gain17160897
    nsv428330CNV Gain18775914

    Human Gene Mutation Database (HGMD): MAP1LC3B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP1LC3B
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP1LC3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609604    OMIM disorders: --

    1 disease for MAP1LC3B:    
    About MalaCards
    sporadic pheochromocytoma


    Find genes that share disorders with MAP1LC3B           About GenesLikeMe


    Export disorders for MAP1LC3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP1LC3B gene, integrated from 10 sources (see all 69):
    (articles sorted by number of sources associating them with MAP1LC3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes. (PubMed id 15355958)1, 2, 9 Tanida I.... Kominami E. (J. Biol. Chem. 2004)
    2. Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis. (PubMed id 23209295)1, 2 Zhu Y.... Brady N.R. (J. Biol. Chem. 2013)
    3. Arginine68 is an essential residue for the C-terminal cleavage of human Atg8 family proteins. (PubMed id 23721406)1, 2 Liu C.... Yu L. (BMC Cell Biol. 2013)
    4. MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins. (PubMed id 22948227)1, 2 Colecchia D.... Chiariello M. (Autophagy 2012)
    5. OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation. (PubMed id 21383079)1, 2 Itoh T.... Fukuda M. (J. Cell Biol. 2011)
    6. Network organization of the human autophagy system. (PubMed id 20562859)1, 2 Behrends C....Harper J.W. (Nature 2010)
    7. LC3 conjugation system in mammalian autophagy. (PubMed id 15325588)1, 2 Tanida I.... Kominami E. (Int. J. Biochem. Cell Biol. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. (PubMed id 15187094)1, 2 Tanida I....Kominami E. (J. Biol. Chem. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81631 HGNC: 13352 AceView: MAP1LC3B Ensembl:ENSG00000140941 euGenes: HUgn81631
    ECgene: MAP1LC3B H-InvDB: MAP1LC3B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAP1LC3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAP1LC3B gene:
    Search GeneIP for patents involving MAP1LC3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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