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Aliases for MAP1LC3B Gene

Aliases for MAP1LC3B Gene

  • Microtubule-Associated Protein 1 Light Chain 3 Beta 2 3 4
  • Autophagy-Related Ubiquitin-Like Modifier LC3 B 3 4
  • MAP1 Light Chain 3-Like Protein 2 3 4
  • MAP1A/MAP1B Light Chain 3 B 3 4
  • MAP1A/MAP1B LC3 B 3 4
  • LC3B 3 6
  • Microtubule-Associated Proteins 1A/1B Light Chain 3B 3
  • Autophagy-Related Protein LC3 B 4
  • MAP1A/1BLC3 3
  • MAP1LC3B-A 3
  • MAP1ALC3 4
  • ATG8F 3

External Ids for MAP1LC3B Gene

Summaries for MAP1LC3B Gene

Entrez Gene Summary for MAP1LC3B Gene

  • The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP1LC3B Gene

MAP1LC3B (Microtubule-Associated Protein 1 Light Chain 3 Beta) is a Protein Coding gene. Diseases associated with MAP1LC3B include sporadic pheochromocytoma. Among its related pathways are Senescence and Autophagy. An important paralog of this gene is MAP1LC3C.

UniProtKB/Swiss-Prot for MAP1LC3B Gene

  • Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

Gene Wiki entry for MAP1LC3B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP1LC3B Gene

Genomics for MAP1LC3B Gene

Genomic Location for MAP1LC3B Gene

Start:
87,383,995 bp from pter
End:
87,404,779 bp from pter
Size:
20,785 bases
Orientation:
Plus strand

Genomic View for MAP1LC3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP1LC3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP1LC3B Gene

Regulatory Elements for MAP1LC3B Gene

Proteins for MAP1LC3B Gene

  • Protein details for MAP1LC3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZQ8-MLP3B_HUMAN
    Recommended name:
    Microtubule-associated proteins 1A/1B light chain 3B
    Protein Accession:
    Q9GZQ8
    Secondary Accessions:
    • Q6NW02

    Protein attributes for MAP1LC3B Gene

    Size:
    125 amino acids
    Molecular mass:
    14688 Da
    Quaternary structure:
    • 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts at microtubules with CABP1 (via EF-hands 1 and 2) but not with calmodulin. Interacts with FYCO1 (via C-terminus). Interacts with TP53INP1 and TP53INP2. Interacts with TBC1D25. Directly interacts with SQSTM1; this interaction leads to MAP1LC3B recruitment to inclusion bodies containing polyubiquitinated protein aggregates and to inclusion body degradation by autophagy. Interacts with ATG4B, MAPK15 and BNIP3. Interacts with MAPB1, KEAP1, PCM1, OFD1, CEP131, and TECPR2. Interacts with TBC1D5 (PubMed:22354992).

    Three dimensional structures from OCA and Proteopedia for MAP1LC3B Gene

neXtProt entry for MAP1LC3B Gene

Proteomics data for MAP1LC3B Gene at MOPED

Post-translational modifications for MAP1LC3B Gene

  • Phosphorylation at Thr-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE) (By similarity). Interaction with MAPK15 reduces the inhibitory phosphorylation and increases autophagy activity.
  • The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine
  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II (PubMed:15187094).
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys51 and Lys65

Other Protein References for MAP1LC3B Gene

No data available for DME Specific Peptides for MAP1LC3B Gene

Domains for MAP1LC3B Gene

Protein Domains for MAP1LC3B Gene

UniProtKB/Swiss-Prot:

MLP3B_HUMAN
Family:
  • Belongs to the ATG8 family.:
    • Q9GZQ8
genes like me logo Genes that share domains with MAP1LC3B: view

No data available for Gene Families for MAP1LC3B Gene

Function for MAP1LC3B Gene

Molecular function for MAP1LC3B Gene

UniProtKB/Swiss-Prot Function: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

Gene Ontology (GO) - Molecular Function for MAP1LC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15187094
GO:0008017 microtubule binding IBA --
genes like me logo Genes that share ontologies with MAP1LC3B: view

Phenotypes for MAP1LC3B Gene

MGI mutant phenotypes for MAP1LC3B:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with MAP1LC3B: view

Animal Models for MAP1LC3B Gene

MGI Knock Outs for MAP1LC3B:

miRNA for MAP1LC3B Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MAP1LC3B Gene

Localization for MAP1LC3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP1LC3B Gene

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes. Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP1LC3B Gene COMPARTMENTS Subcellular localization image for MAP1LC3B gene
Compartment Confidence
cytoskeleton 5
vacuole 5
cytosol 3
endoplasmic reticulum 2
lysosome 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MAP1LC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IBA --
GO:0000421 autophagic vacuole membrane IBA --
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IDA 25215947
genes like me logo Genes that share ontologies with MAP1LC3B: view

Pathways for MAP1LC3B Gene

SuperPathways for MAP1LC3B Gene

Superpath Contained pathways
1 Senescence and Autophagy
genes like me logo Genes that share pathways with MAP1LC3B: view

Pathways by source for MAP1LC3B Gene

1 BioSystems pathway for MAP1LC3B Gene

Gene Ontology (GO) - Biological Process for MAP1LC3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly IBA --
GO:0000422 mitochondrion degradation IBA --
GO:0006914 autophagy --
GO:0006995 cellular response to nitrogen starvation IBA --
GO:0044804 nucleophagy IBA --
genes like me logo Genes that share ontologies with MAP1LC3B: view

Transcripts for MAP1LC3B Gene

Unigene Clusters for MAP1LC3B Gene

Microtubule-associated protein 1 light chain 3 beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP1LC3B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2:

Relevant External Links for MAP1LC3B Gene

GeneLoc Exon Structure for
MAP1LC3B
ECgene alternative splicing isoforms for
MAP1LC3B

Expression for MAP1LC3B Gene

mRNA expression in normal human tissues for MAP1LC3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MAP1LC3B Gene

SOURCE GeneReport for Unigene cluster for MAP1LC3B Gene Hs.356061

mRNA Expression by UniProt/SwissProt for MAP1LC3B Gene

Q9GZQ8-MLP3B_HUMAN
Tissue specificity: Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver.
genes like me logo Genes that share expressions with MAP1LC3B: view

Orthologs for MAP1LC3B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP1LC3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP1LC3B 36
  • 99.73 (n)
  • 100 (a)
MAP1LC3B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAP1LC3B 36
  • 89.33 (n)
  • 99.2 (a)
MAP1LC3B 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP1LC3B 36
  • 90.67 (n)
  • 99.2 (a)
mouse
(Mus musculus)
Mammalia Gm5612 37
  • 80 (a)
ManyToMany
Map1lc3b 36
  • 84.8 (n)
  • 95.2 (a)
Map1lc3b 16
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 98 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Map1lc3b 36
  • 85.87 (n)
  • 96 (a)
chicken
(Gallus gallus)
Aves MAP1LC3B 36
  • 83.47 (n)
  • 95.2 (a)
MAP1LC3B 37
  • 96 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 74 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia MGC68744 36
tropical clawed frog
(Silurana tropicalis)
Amphibia map1lc3b 36
  • 77.15 (n)
  • 94.35 (a)
MGC76283 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10143 36
zebrafish
(Danio rerio)
Actinopterygii map1lc3b 36
  • 74.59 (n)
  • 93.44 (a)
map1lc3b 37
  • 93 (a)
OneToMany
wufb60g11 36
worm
(Caenorhabditis elegans)
Secernentea lgg-2 37
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG8 37
  • 34 (a)
OneToMany
Species with no ortholog for MAP1LC3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP1LC3B Gene

ENSEMBL:
Gene Tree for MAP1LC3B (if available)
TreeFam:
Gene Tree for MAP1LC3B (if available)

Paralogs for MAP1LC3B Gene

Paralogs for MAP1LC3B Gene

genes like me logo Genes that share paralogs with MAP1LC3B: view

Variants for MAP1LC3B Gene

Sequence variations from dbSNP and Humsavar for MAP1LC3B Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs7865 -- 87,403,202(+) ATCAT(C/G)AAACA utr-variant-3-prime
rs9903 -- 87,403,501(-) AAAGG(C/T)GGCGG utr-variant-3-prime
rs34419 -- 87,401,047(-) caagc(A/G)attct intron-variant
rs40068 -- 87,401,112(-) tctgt(C/T)gccca intron-variant
rs40069 -- 87,400,979(-) atttt(G/T)gtatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP1LC3B Gene

Variant ID Type Subtype PubMed ID
nsv907153 CNV Loss 21882294
nsv510694 CNV Loss 20534489
nsv907156 CNV Loss 21882294
nsv833320 CNV Gain 17160897
nsv428330 CNV Gain 18775914
dgv499n67 CNV Gain 20364138
dgv2950n71 CNV Loss 21882294

Relevant External Links for MAP1LC3B Gene

HapMap Linkage Disequilibrium report
MAP1LC3B
Human Gene Mutation Database (HGMD)
MAP1LC3B

Disorders for MAP1LC3B Gene

(1) MalaCards Diseases for MAP1LC3B Gene

Search for MAP1LC3B Gene in MalaCards »
genes like me logo Genes that share disorders with MAP1LC3B: view

No data available for UniProtKB/Swiss-Prot for MAP1LC3B Gene

Publications for MAP1LC3B Gene

  1. Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes. (PMID: 15355958) Tanida I. … Kominami E. (J. Biol. Chem. 2004) 3 4 23
  2. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. (PMID: 20038797) Rouschop K.M. … Wouters B.G. (J. Clin. Invest. 2010) 3 23
  3. LC3 conjugation system in mammalian autophagy. (PMID: 15325588) Tanida I. … Kominami E. (Int. J. Biochem. Cell Biol. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. (PMID: 12740394) He H. … Yu L. (J. Biol. Chem. 2003) 3 4

Products for MAP1LC3B Gene

  • antibodies-online proteins for MAP1LC3B
  • antibodies-online antibodies for MAP1LC3B
  • antibodies-online kits for MAP1LC3B

Sources for MAP1LC3B Gene

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