Aliases for MAP1LC3A Gene
- Microtubule Associated Protein 1 Light Chain 3 Alpha 2 3 5
- Autophagy-Related Ubiquitin-Like Modifier LC3 A 3 4
- MAP1 Light Chain 3-Like Protein 1 3 4
- MAP1A/MAP1B Light Chain 3 A 3 4
- MAP1A/MAP1B LC3 A 3 4
- Microtubule-Associated Proteins 1A/1B Light Chain 3A 3
- Microtubule-Associated Protein 1 Light Chain 3 Alpha 4
- Microtubule-Associated Proteins 1A/1B Light Chain 3 3
External Ids for MAP1LC3A Gene
Previous GeneCards Identifiers for MAP1LC3A Gene
MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]
GeneCards Summary for MAP1LC3A Gene
MAP1LC3A (Microtubule Associated Protein 1 Light Chain 3 Alpha) is a Protein Coding gene. Diseases associated with MAP1LC3A include Nasu-Hakola Disease and Leber Congenital Amaurosis 6. Among its related pathways are Cellular Senescence (REACTOME) and Pink/Parkin Mediated Mitophagy. GO annotations related to this gene include microtubule binding and phosphatidylethanolamine binding. An important paralog of this gene is MAP1LC3B.
UniProtKB/Swiss-Prot for MAP1LC3A Gene
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600).