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Aliases for MAP1LC3A Gene

Aliases for MAP1LC3A Gene

  • Microtubule-Associated Protein 1 Light Chain 3 Alpha 2 3 4
  • Autophagy-Related Ubiquitin-Like Modifier LC3 A 3 4
  • MAP1 Light Chain 3-Like Protein 1 3 4
  • MAP1A/MAP1B Light Chain 3 A 3 4
  • MAP1A/MAP1B LC3 A 3 4
  • MAP1ALC3 3 6
  • MAP1BLC3 3 6
  • Microtubule-Associated Proteins 1A/1B Light Chain 3A 3
  • Microtubule-Associated Proteins 1A/1B Light Chain 3 3
  • Autophagy-Related Protein LC3 A 4
  • MAP1A/1B Light Chain 3 A 3
  • ATG8E 3
  • LC3A 3
  • LC3 3

External Ids for MAP1LC3A Gene

Previous GeneCards Identifiers for MAP1LC3A Gene

  • GC20P032896
  • GC20P033806
  • GC20P033850
  • GC20P032598
  • GC20P033134
  • GC20P029915

Summaries for MAP1LC3A Gene

Entrez Gene Summary for MAP1LC3A Gene

  • MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]

GeneCards Summary for MAP1LC3A Gene

MAP1LC3A (Microtubule-Associated Protein 1 Light Chain 3 Alpha) is a Protein Coding gene. Among its related pathways are Senescence and Autophagy. GO annotations related to this gene include phospholipid binding and phosphatidylethanolamine binding. An important paralog of this gene is MAP1LC3C.

UniProtKB/Swiss-Prot for MAP1LC3A Gene

  • Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Gene Wiki entry for MAP1LC3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP1LC3A Gene

Genomics for MAP1LC3A Gene

Regulatory Elements for MAP1LC3A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAP1LC3A Gene

Start:
34,546,854 bp from pter
End:
34,560,345 bp from pter
Size:
13,492 bases
Orientation:
Plus strand

Genomic View for MAP1LC3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP1LC3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP1LC3A Gene

Proteins for MAP1LC3A Gene

  • Protein details for MAP1LC3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H492-MLP3A_HUMAN
    Recommended name:
    Microtubule-associated proteins 1A/1B light chain 3A
    Protein Accession:
    Q9H492
    Secondary Accessions:
    • E1P5P4
    • E1P5P5
    • Q9BXW5

    Protein attributes for MAP1LC3A Gene

    Size:
    121 amino acids
    Molecular mass:
    14272 Da
    Quaternary structure:
    • 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts with SQSTM1 (By similarity). Interacts with TP53INP1 and TP53INP2. Directly interacts with SQSTM1; this interaction leads to MAP1LC3A recruitment to inclusion bodies containing polyubiquitinated protein aggregates and to inclusion body degradation by autophagy. Interacts with ATG13 and ULK1. Interacts with TBC1D5 (PubMed:22354992).

    Three dimensional structures from OCA and Proteopedia for MAP1LC3A Gene

    Alternative splice isoforms for MAP1LC3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP1LC3A Gene

Proteomics data for MAP1LC3A Gene at MOPED

Post-translational modifications for MAP1LC3A Gene

  • Phosphorylation at Ser-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE). Interaction with MAPK15 reduces the inhibitory phosphorylation and increases autophagy activity.
  • The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.
  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II (PubMed:15187094).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP1LC3A Gene

Antibody Products

  • R&D Systems Antibodies for MAP1LC3A (LC3/MAP1LC3A)
  • Cell Signaling Technology (CST) Antibodies for MAP1LC3A (LC3A)

No data available for DME Specific Peptides for MAP1LC3A Gene

Domains for MAP1LC3A Gene

Protein Domains for MAP1LC3A Gene

Suggested Antigen Peptide Sequences for MAP1LC3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H492

UniProtKB/Swiss-Prot:

MLP3A_HUMAN :
  • Q9H492
Family:
  • Belongs to the ATG8 family.
genes like me logo Genes that share domains with MAP1LC3A: view

No data available for Gene Families for MAP1LC3A Gene

Function for MAP1LC3A Gene

Molecular function for MAP1LC3A Gene

UniProtKB/Swiss-Prot Function: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Gene Ontology (GO) - Molecular Function for MAP1LC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11096062
GO:0005543 phospholipid binding IDA 15187094
GO:0008017 microtubule binding IBA --
GO:0008429 phosphatidylethanolamine binding IDA 16303767
genes like me logo Genes that share ontologies with MAP1LC3A: view

Phenotypes for MAP1LC3A Gene

GenomeRNAi human phenotypes for MAP1LC3A:
genes like me logo Genes that share phenotypes with MAP1LC3A: view

Animal Model Products

CRISPR Products

miRNA for MAP1LC3A Gene

miRTarBase miRNAs that target MAP1LC3A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MAP1LC3A Gene

Localization for MAP1LC3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP1LC3A Gene

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP1LC3A Gene COMPARTMENTS Subcellular localization image for MAP1LC3A gene
Compartment Confidence
cytoskeleton 5
cytosol 5
vacuole 5
endosome 2
nucleus 2
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MAP1LC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IBA --
GO:0000421 autophagic vacuole membrane IBA --
GO:0005737 cytoplasm --
GO:0005770 late endosome IEA --
GO:0005776 autophagic vacuole IDA 12740394
genes like me logo Genes that share ontologies with MAP1LC3A: view

Pathways for MAP1LC3A Gene

SuperPathways for MAP1LC3A Gene

Superpath Contained pathways
1 Senescence and Autophagy
genes like me logo Genes that share pathways with MAP1LC3A: view

Pathways by source for MAP1LC3A Gene

1 BioSystems pathway for MAP1LC3A Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for MAP1LC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagic vacuole assembly ISS --
GO:0000422 mitochondrion degradation IGI 22267086
GO:0006914 autophagy --
GO:0006995 cellular response to nitrogen starvation IBA --
GO:0044804 nucleophagy IBA --
genes like me logo Genes that share ontologies with MAP1LC3A: view

Transcripts for MAP1LC3A Gene

Unigene Clusters for MAP1LC3A Gene

Microtubule-associated protein 1 light chain 3 alpha:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP1LC3A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP1LC3A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - - -
SP2: -
SP3:

Relevant External Links for MAP1LC3A Gene

GeneLoc Exon Structure for
MAP1LC3A
ECgene alternative splicing isoforms for
MAP1LC3A

Expression for MAP1LC3A Gene

mRNA expression in normal human tissues for MAP1LC3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP1LC3A Gene

SOURCE GeneReport for Unigene cluster for MAP1LC3A Gene Hs.632273

mRNA Expression by UniProt/SwissProt for MAP1LC3A Gene

Q9H492-MLP3A_HUMAN
Tissue specificity: Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.
genes like me logo Genes that share expressions with MAP1LC3A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MAP1LC3A Gene

Orthologs for MAP1LC3A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP1LC3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP1LC3A 35
  • 98.35 (n)
  • 97.52 (a)
MAP1LC3A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAP1LC3A 35
  • 95.59 (n)
  • 99.17 (a)
MAP1LC3A 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP1LC3A 35
  • 95.04 (n)
  • 98.35 (a)
MAP1LC3A 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map1lc3a 35
  • 93.11 (n)
  • 100 (a)
Map1lc3a 16
Map1lc3a 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP1LC3A 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP1LC3A 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map1lc3a 35
  • 93.39 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves MAP1LC3A 35
  • 85.95 (n)
  • 94.21 (a)
MAP1LC3A 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP1LC3A 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia map1lc3a-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia map1lc3a 35
  • 79.44 (n)
  • 92.5 (a)
Str.13107 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8909 35
zebrafish
(Danio rerio)
Actinopterygii map1lc3a 35
  • 81.11 (n)
  • 95.83 (a)
map1lc3a 36
  • 86 (a)
OneToOne
wufc38e10 35
worm
(Caenorhabditis elegans)
Secernentea lgg-2 35
  • 55.85 (n)
  • 59.65 (a)
lgg-2 36
  • 50 (a)
OneToMany
lgg-2 37
  • 59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG8 36
  • 34 (a)
OneToMany
Species with no ortholog for MAP1LC3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP1LC3A Gene

ENSEMBL:
Gene Tree for MAP1LC3A (if available)
TreeFam:
Gene Tree for MAP1LC3A (if available)

Paralogs for MAP1LC3A Gene

Paralogs for MAP1LC3A Gene

Selected SIMAP similar genes for MAP1LC3A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAP1LC3A: view

Variants for MAP1LC3A Gene

Sequence variations from dbSNP and Humsavar for MAP1LC3A Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1040746 -- 34,557,943(+) CCCCC(A/C)AAAAA upstream-variant-2KB, intron-variant
rs1040747 -- 34,558,028(+) CTCTG(C/G)AGGTC upstream-variant-2KB, intron-variant
rs1964848 -- 34,557,666(+) TCACA(C/T)CTGTA upstream-variant-2KB, intron-variant
rs2144956 -- 34,558,064(+) GCTCG(A/G)GCCCG upstream-variant-2KB, intron-variant
rs2424994 -- 34,545,113(+) AAATA(C/T)GTTAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAP1LC3A Gene

Variant ID Type Subtype PubMed ID
nsv3359 CNV Loss 18451855
esv2666225 CNV Deletion 23128226

Relevant External Links for MAP1LC3A Gene

HapMap Linkage Disequilibrium report
MAP1LC3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP1LC3A Gene

Disorders for MAP1LC3A Gene

Relevant External Links for MAP1LC3A

Human Genome Epidemiology (HuGE) Navigator
MAP1LC3A
genes like me logo Genes that share disorders with MAP1LC3A: view

No data available for UniProtKB/Swiss-Prot for MAP1LC3A Gene

Publications for MAP1LC3A Gene

  1. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. (PMID: 17580304) Pankiv S. … Johansen T. (J. Biol. Chem. 2007) 2 3 4
  2. Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. (PMID: 12740394) He H. … Yu L. (J. Biol. Chem. 2003) 3 4
  3. HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. (PMID: 15187094) Tanida I. … Kominami E. (J. Biol. Chem. 2004) 3 4
  4. TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death. (PMID: 22421968) Seillier M. … Dusetti N.J. (Cell Death Differ. 2012) 3 4
  5. Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. (PMID: 22354992) Popovic D. … Dikic I. (Mol. Cell. Biol. 2012) 3 4

Products for MAP1LC3A Gene

Sources for MAP1LC3A Gene

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