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Aliases for MAP1LC3A Gene

Aliases for MAP1LC3A Gene

  • Microtubule Associated Protein 1 Light Chain 3 Alpha 2 3 5
  • Microtubule-Associated Protein 1 Light Chain 3 Alpha 3 4
  • Autophagy-Related Ubiquitin-Like Modifier LC3 A 3 4
  • MAP1 Light Chain 3-Like Protein 1 3 4
  • MAP1A/MAP1B Light Chain 3 A 3 4
  • MAP1A/MAP1B LC3 A 3 4
  • Microtubule-Associated Proteins 1A/1B Light Chain 3 3
  • Autophagy-Related Protein LC3 A 4
  • MAP1A/1B Light Chain 3 A 3
  • MAP1ALC3 3
  • MAP1BLC3 3
  • ATG8E 3
  • LC3A 3
  • LC3 3

External Ids for MAP1LC3A Gene

Previous GeneCards Identifiers for MAP1LC3A Gene

  • GC20P032896
  • GC20P033806
  • GC20P033850
  • GC20P032598
  • GC20P033134
  • GC20P029915

Summaries for MAP1LC3A Gene

Entrez Gene Summary for MAP1LC3A Gene

  • MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]

GeneCards Summary for MAP1LC3A Gene

MAP1LC3A (Microtubule Associated Protein 1 Light Chain 3 Alpha) is a Protein Coding gene. Diseases associated with MAP1LC3A include nasu-hakola disease. Among its related pathways are Cellular Senescence and Senescence and Autophagy. GO annotations related to this gene include microtubule binding and phosphatidylethanolamine binding. An important paralog of this gene is MAP1LC3C.

UniProtKB/Swiss-Prot for MAP1LC3A Gene

  • Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Gene Wiki entry for MAP1LC3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP1LC3A Gene

Genomics for MAP1LC3A Gene

Regulatory Elements for MAP1LC3A Gene

Genomic Location for MAP1LC3A Gene

Chromosome:
20
Start:
34,546,830 bp from pter
End:
34,560,345 bp from pter
Size:
13,516 bases
Orientation:
Plus strand

Genomic View for MAP1LC3A Gene

Genes around MAP1LC3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP1LC3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP1LC3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP1LC3A Gene

Proteins for MAP1LC3A Gene

  • Protein details for MAP1LC3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H492-MLP3A_HUMAN
    Recommended name:
    Microtubule-associated proteins 1A/1B light chain 3A
    Protein Accession:
    Q9H492
    Secondary Accessions:
    • E1P5P4
    • E1P5P5
    • Q9BXW5

    Protein attributes for MAP1LC3A Gene

    Size:
    121 amino acids
    Molecular mass:
    14272 Da
    Quaternary structure:
    • 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts with SQSTM1 (By similarity). Interacts with TP53INP1 and TP53INP2. Directly interacts with SQSTM1; this interaction leads to MAP1LC3A recruitment to inclusion bodies containing polyubiquitinated protein aggregates and to inclusion body degradation by autophagy. Interacts with ATG13 and ULK1. Interacts with TBC1D5 (PubMed:22354992). Found in a complex with UBQLN1 and UBQLN2. Interacts with UBQLN4 (via STI1 1 and 2 domains). Interacts with UBQLN1 in the presence of UBQLN4. Interacts with TRIM5 (PubMed:25127057). Interacts with MEFV (PubMed:26347139).

    Three dimensional structures from OCA and Proteopedia for MAP1LC3A Gene

    Alternative splice isoforms for MAP1LC3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP1LC3A Gene

Proteomics data for MAP1LC3A Gene at MOPED

Post-translational modifications for MAP1LC3A Gene

  • Phosphorylation at Ser-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE). Interaction with MAPK15 reduces the inhibitory phosphorylation and increases autophagy activity.
  • The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.
  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II (PubMed:15187094).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP1LC3A Gene

Antibody Products

  • R&D Systems Antibodies for MAP1LC3A (LC3/MAP1LC3A)
  • Cell Signaling Technology (CST) Antibodies for MAP1LC3A (LC3A)

No data available for DME Specific Peptides for MAP1LC3A Gene

Domains & Families for MAP1LC3A Gene

Gene Families for MAP1LC3A Gene

Protein Domains for MAP1LC3A Gene

Suggested Antigen Peptide Sequences for MAP1LC3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H492

UniProtKB/Swiss-Prot:

MLP3A_HUMAN :
  • Belongs to the ATG8 family.
Family:
  • Belongs to the ATG8 family.
genes like me logo Genes that share domains with MAP1LC3A: view

Function for MAP1LC3A Gene

Molecular function for MAP1LC3A Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Phenotypes for MAP1LC3A Gene

GenomeRNAi human phenotypes for MAP1LC3A:
genes like me logo Genes that share phenotypes with MAP1LC3A: view

Animal Model Products

miRNA for MAP1LC3A Gene

miRTarBase miRNAs that target MAP1LC3A

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP1LC3A Gene

Localization for MAP1LC3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP1LC3A Gene

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome. Note=LC3-II binds to the autophagic membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP1LC3A Gene COMPARTMENTS Subcellular localization image for MAP1LC3A gene
Compartment Confidence
cytosol 5
vacuole 5
cytoskeleton 4
nucleus 3
endosome 2
lysosome 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for MAP1LC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with MAP1LC3A: view

Pathways & Interactions for MAP1LC3A Gene

genes like me logo Genes that share pathways with MAP1LC3A: view

Pathways by source for MAP1LC3A Gene

1 GeneTex pathway for MAP1LC3A Gene
1 BioSystems pathway for MAP1LC3A Gene
1 R&D Systems pathway for MAP1LC3A Gene

SIGNOR curated interactions for MAP1LC3A Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MAP1LC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000422 mitophagy IGI 22267086
GO:0000423 macromitophagy TAS --
GO:0006914 autophagy IEA --
genes like me logo Genes that share ontologies with MAP1LC3A: view

Drugs & Compounds for MAP1LC3A Gene

(14) Drugs for MAP1LC3A Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cabazitaxel Approved Pharma 0
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1844
Griseofulvin Approved Pharma 6
2-Methoxyestradiol (2-MeOE2) Pharma Apoptotic, antiproliferative and antiangiogenic agent 0
CK-636 Pharma Arp2/3 complex inhibitor 0
genes like me logo Genes that share compounds with MAP1LC3A: view

Transcripts for MAP1LC3A Gene

Unigene Clusters for MAP1LC3A Gene

Microtubule-associated protein 1 light chain 3 alpha:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP1LC3A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - - -
SP2: -
SP3:

Relevant External Links for MAP1LC3A Gene

GeneLoc Exon Structure for
MAP1LC3A
ECgene alternative splicing isoforms for
MAP1LC3A

Expression for MAP1LC3A Gene

mRNA expression in normal human tissues for MAP1LC3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAP1LC3A Gene

This gene is overexpressed in Brain (14.8), Fetal Brain (13.4), Retina (10.9), Frontal cortex (8.3), and Spinal cord (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP1LC3A Gene



SOURCE GeneReport for Unigene cluster for MAP1LC3A Gene Hs.632273

mRNA Expression by UniProt/SwissProt for MAP1LC3A Gene

Q9H492-MLP3A_HUMAN
Tissue specificity: Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with MAP1LC3A: view

Protein tissue co-expression partners for MAP1LC3A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MAP1LC3A Gene

Orthologs for MAP1LC3A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP1LC3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP1LC3A 35
  • 98.35 (n)
  • 97.52 (a)
MAP1LC3A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAP1LC3A 36
  • 90 (a)
OneToOne
MAP1LC3A 35
  • 95.59 (n)
  • 99.17 (a)
dog
(Canis familiaris)
Mammalia MAP1LC3A 35
  • 95.04 (n)
  • 98.35 (a)
MAP1LC3A 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map1lc3a 16
Map1lc3a 36
  • 91 (a)
OneToOne
Map1lc3a 35
  • 93.11 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia MAP1LC3A 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP1LC3A 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map1lc3a 35
  • 93.39 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves MAP1LC3A 36
  • 87 (a)
OneToOne
MAP1LC3A 35
  • 85.95 (n)
  • 94.21 (a)
lizard
(Anolis carolinensis)
Reptilia MAP1LC3A 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia map1lc3a-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia map1lc3a 35
  • 79.44 (n)
  • 92.5 (a)
Str.13107 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8909 35
zebrafish
(Danio rerio)
Actinopterygii map1lc3a 36
  • 86 (a)
OneToOne
map1lc3a 35
  • 81.11 (n)
  • 95.83 (a)
wufc38e10 35
worm
(Caenorhabditis elegans)
Secernentea lgg-2 35
  • 55.85 (n)
  • 59.65 (a)
lgg-2 37
  • 59 (a)
lgg-2 36
  • 50 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG8 36
  • 34 (a)
OneToMany
Species with no ortholog for MAP1LC3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP1LC3A Gene

ENSEMBL:
Gene Tree for MAP1LC3A (if available)
TreeFam:
Gene Tree for MAP1LC3A (if available)

Paralogs for MAP1LC3A Gene

Paralogs for MAP1LC3A Gene

(8) SIMAP similar genes for MAP1LC3A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAP1LC3A: view

Variants for MAP1LC3A Gene

Sequence variations from dbSNP and Humsavar for MAP1LC3A Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1040746 -- 34,557,943(+) CCCCC(A/C)AAAAA intron-variant, upstream-variant-2KB
rs1040747 -- 34,558,028(+) CTCTG(C/G)AGGTC intron-variant, upstream-variant-2KB
rs2424994 -- 34,545,113(+) AAATA(C/T)GTTAG upstream-variant-2KB
rs6059909 -- 34,551,887(+) AAAAA(A/C)CAAAT intron-variant
rs6059910 -- 34,554,303(+) TGTTT(C/T)ACCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP1LC3A Gene

Variant ID Type Subtype PubMed ID
nsv3359 CNV Loss 18451855
esv2666225 CNV Deletion 23128226

Variation tolerance for MAP1LC3A Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP1LC3A Gene

HapMap Linkage Disequilibrium report
MAP1LC3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP1LC3A Gene

Disorders for MAP1LC3A Gene

MalaCards: The human disease database

(1) MalaCards diseases for MAP1LC3A Gene - From: GeneCards

Disorder Aliases PubMed IDs
nasu-hakola disease
  • polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAP1LC3A

Human Genome Epidemiology (HuGE) Navigator
MAP1LC3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP1LC3A
genes like me logo Genes that share disorders with MAP1LC3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP1LC3A Gene

Publications for MAP1LC3A Gene

  1. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. (PMID: 17580304) Pankiv S. … Johansen T. (J. Biol. Chem. 2007) 2 3 4 67
  2. Gene localization and developmental expression of light chain 3: a common subunit of microtubule-associated protein 1A(MAP1A) and MAP1B. (PMID: 8833088) Mann S.S. … Hammarback J.A. (J. Neurosci. Res. 1996) 2 3
  3. PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins. (PMID: 25498145) McEwan D.G. … Dikic I. (Mol. Cell 2015) 3
  4. Autophagy receptor NDP52 regulates pathogen-containing autophagosome maturation. (PMID: 25771791) Verlhac P. … Faure M. (Cell Host Microbe 2015) 3
  5. The HIV proteins Tat and Nef promote human bone marrow mesenchymal stem cell senescence and alter osteoblastic differentiation. (PMID: 25847297) Beaupere C. … Lagathu C. (Aging Cell 2015) 3

Products for MAP1LC3A Gene

Sources for MAP1LC3A Gene

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