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Aliases for MAP1LC3A Gene

Aliases for MAP1LC3A Gene

  • Microtubule Associated Protein 1 Light Chain 3 Alpha 2 3 5
  • Autophagy-Related Ubiquitin-Like Modifier LC3 A 3 4
  • MAP1 Light Chain 3-Like Protein 1 3 4
  • MAP1A/MAP1B Light Chain 3 A 3 4
  • MAP1A/MAP1B LC3 A 3 4
  • Microtubule-Associated Proteins 1A/1B Light Chain 3A 3
  • Microtubule-Associated Protein 1 Light Chain 3 Alpha 4
  • Microtubule-Associated Proteins 1A/1B Light Chain 3 3
  • Autophagy-Related Protein LC3 A 4
  • MAP1A/1B Light Chain 3 A 3
  • MAP1ALC3 3
  • MAP1BLC3 3
  • ATG8E 3
  • LC3A 3
  • LC3 3

External Ids for MAP1LC3A Gene

Previous GeneCards Identifiers for MAP1LC3A Gene

  • GC20P032896
  • GC20P033806
  • GC20P033850
  • GC20P032598
  • GC20P033134
  • GC20P029915

Summaries for MAP1LC3A Gene

Entrez Gene Summary for MAP1LC3A Gene

  • MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]

GeneCards Summary for MAP1LC3A Gene

MAP1LC3A (Microtubule Associated Protein 1 Light Chain 3 Alpha) is a Protein Coding gene. Diseases associated with MAP1LC3A include Nasu-Hakola Disease and Lacrimal Gland Adenocarcinoma. Among its related pathways are Autophagy Pathway and Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling. GO annotations related to this gene include microtubule binding and phosphatidylethanolamine binding. An important paralog of this gene is MAP1LC3B.

UniProtKB/Swiss-Prot for MAP1LC3A Gene

  • Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600).

Gene Wiki entry for MAP1LC3A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP1LC3A Gene

Genomics for MAP1LC3A Gene

Regulatory Elements for MAP1LC3A Gene

Enhancers for MAP1LC3A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G034522 1.6 Ensembl ENCODE dbSUPER 33.5 -21.8 -21804 5.9 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 MAP1LC3A ITCH TP53INP2 ENSG00000231034 PIGU NCOA6 GC20M034527 GC20P034523 ENSG00000206582
GH20G034514 1.4 ENCODE dbSUPER 33.3 -30.8 -30786 3.1 PKNOX1 MLX CREB3L1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 MAP1LC3A PIGU TRPC4AP ZNF341-AS1 EIF6 NCOA6 TP53INP2 ITCH DYNLRB1 GC20M034509
GH20G034511 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22.4 -34.3 -34296 2.4 FOXA2 PKNOX1 ARID4B DMAP1 ZNF48 RARA HSF1 ZNF350 CREM KLF11 MAP1LC3A NCOA6 DYNLRB1 GC20M034509
GH20G034578 1.4 Ensembl ENCODE dbSUPER 24.1 +33.8 33762 4.0 HDGF PKNOX1 ARID4B FEZF1 ZNF48 SLC30A9 FOS JUNB REST TBX21 MAP1LC3A PIGU NCOA6 TP53INP2 GC20P034589 GC20M034549
GH20G034334 1 ENCODE 31.9 -211.1 -211106 3.0 PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF48 ZNF121 SLC30A9 FOS SP5 MAP1LC3A ITCH ENSG00000234087 AHCY
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAP1LC3A on UCSC Golden Path with GeneCards custom track

Genomic Location for MAP1LC3A Gene

Chromosome:
20
Start:
34,546,830 bp from pter
End:
34,560,345 bp from pter
Size:
13,516 bases
Orientation:
Plus strand

Genomic View for MAP1LC3A Gene

Genes around MAP1LC3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP1LC3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP1LC3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP1LC3A Gene

Proteins for MAP1LC3A Gene

  • Protein details for MAP1LC3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H492-MLP3A_HUMAN
    Recommended name:
    Microtubule-associated proteins 1A/1B light chain 3A
    Protein Accession:
    Q9H492
    Secondary Accessions:
    • E1P5P4
    • E1P5P5
    • Q9BXW5

    Protein attributes for MAP1LC3A Gene

    Size:
    121 amino acids
    Molecular mass:
    14272 Da
    Quaternary structure:
    • 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts with TP53INP1 and TP53INP2 (PubMed:19056683, PubMed:22470510). Directly interacts with SQSTM1; this interaction leads to MAP1LC3A recruitment to inclusion bodies containing polyubiquitinated protein aggregates and to inclusion body degradation by autophagy (PubMed:17580304). Interacts with ATG13 (PubMed:24290141, PubMed:23043107). Interacts with ULK1 (PubMed:23043107). Interacts with TBC1D5 (PubMed:22354992). Found in a complex with UBQLN1 and UBQLN2 (PubMed:20529957). Interacts with UBQLN4 (via STI1 1 and 2 domains). Interacts with UBQLN1 in the presence of UBQLN4 (PubMed:23459205). Interacts with TRIM5 (PubMed:25127057). Interacts with MEFV (PubMed:26347139). Interacts with FAM134A, FAM134B and FAM134C (PubMed:26040720).

    Three dimensional structures from OCA and Proteopedia for MAP1LC3A Gene

    Alternative splice isoforms for MAP1LC3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP1LC3A Gene

Post-translational modifications for MAP1LC3A Gene

  • Phosphorylation at Ser-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE). Interaction with MAPK15 reduces the inhibitory phosphorylation and increases autophagy activity.
  • The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.
  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II (PubMed:15187094).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP1LC3A Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAP1LC3A (LC3A)
  • Abcam antibodies for MAP1LC3A
  • Cloud-Clone Corp. Antibodies for MAP1LC3A

Protein Products

  • Cloud-Clone Corp. Proteins for MAP1LC3A

Assay Products

  • Cloud-Clone Corp Assay Kits for MAP1LC3A

No data available for DME Specific Peptides for MAP1LC3A Gene

Domains & Families for MAP1LC3A Gene

Gene Families for MAP1LC3A Gene

Protein Domains for MAP1LC3A Gene

Suggested Antigen Peptide Sequences for MAP1LC3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H492

UniProtKB/Swiss-Prot:

MLP3A_HUMAN :
  • Belongs to the ATG8 family.
Family:
  • Belongs to the ATG8 family.
genes like me logo Genes that share domains with MAP1LC3A: view

Function for MAP1LC3A Gene

Molecular function for MAP1LC3A Gene

UniProtKB/Swiss-Prot Function:
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) (PubMed:20713600, PubMed:24290141). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20713600).

Gene Ontology (GO) - Molecular Function for MAP1LC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11096062
GO:0005543 phospholipid binding IDA 15187094
GO:0008429 phosphatidylethanolamine binding IDA 16303767
GO:0031625 ubiquitin protein ligase binding IPI 25127057
genes like me logo Genes that share ontologies with MAP1LC3A: view

Phenotypes for MAP1LC3A Gene

genes like me logo Genes that share phenotypes with MAP1LC3A: view

Animal Model Products

miRNA for MAP1LC3A Gene

miRTarBase miRNAs that target MAP1LC3A

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP1LC3A Gene

Localization for MAP1LC3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP1LC3A Gene

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome. Note=LC3-II binds to the autophagic membranes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAP1LC3A gene
Compartment Confidence
cytosol 5
lysosome 5
cytoskeleton 4
nucleus 3
mitochondrion 2
endosome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MAP1LC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000421 autophagosome membrane TAS --
GO:0005737 cytoplasm IEA --
GO:0005770 late endosome IEA --
GO:0005776 autophagosome IDA,IEA 12740394
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAP1LC3A: view

Pathways & Interactions for MAP1LC3A Gene

genes like me logo Genes that share pathways with MAP1LC3A: view

Pathways by source for MAP1LC3A Gene

1 KEGG pathway for MAP1LC3A Gene
1 R&D Systems pathway for MAP1LC3A Gene

SIGNOR curated interactions for MAP1LC3A Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MAP1LC3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly ISS --
GO:0000422 mitophagy IGI 22267086
GO:0006914 autophagy IEA --
GO:0010040 response to iron(II) ion IEA --
GO:0010288 response to lead ion IEA --
genes like me logo Genes that share ontologies with MAP1LC3A: view

Drugs & Compounds for MAP1LC3A Gene

(14) Drugs for MAP1LC3A Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cabazitaxel Approved Pharma 0
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1967
Griseofulvin Approved, Vet_approved Pharma 6
2-Methoxyestradiol (2-MeOE2) Pharma Apoptotic, antiproliferative and antiangiogenic agent 0
CK-636 Pharma Arp2/3 complex inhibitor 0

(14) ApexBio Compounds for MAP1LC3A Gene

Compound Action Cas Number
2-Methoxyestradiol (2-MeOE2) Apoptotic, antiproliferative and antiangiogenic agent 362-07-2
Cabazitaxel 183133-96-2
CK-636 Arp2/3 complex inhibitor 442632-72-6
CYT997 (Lexibulin) 917111-44-5
Docetaxel Microtubulin disassembly inhibitor 114977-28-5
Epothilone A Microtubule stabilizing macrolide 152044-53-6
Epothilone B (EPO906, Patupilone) Microtubule stabilizing macrolide 152044-54-7
Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium 168555-66-6
Griseofulvin 126-07-8
INH6 1001753-24-7
MPC 6827 hydrochloride Potent microtubule inhibitor 917369-31-4
Plinabulin (NPI-2358) Tumor cell lines inhibitor 714272-27-2
Vinflunine Tartrate 1201898-17-0
Vinorelbine ditartrate Anti-mitotic chemotherapy drug 125317-39-7
genes like me logo Genes that share compounds with MAP1LC3A: view

Drug Products

Transcripts for MAP1LC3A Gene

Unigene Clusters for MAP1LC3A Gene

Microtubule-associated protein 1 light chain 3 alpha:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP1LC3A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - - -
SP2: -
SP3:

Relevant External Links for MAP1LC3A Gene

GeneLoc Exon Structure for
MAP1LC3A
ECgene alternative splicing isoforms for
MAP1LC3A

Expression for MAP1LC3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAP1LC3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAP1LC3A Gene

This gene is overexpressed in Brain (14.8), Fetal Brain (13.4), Retina (10.9), Frontal cortex (8.3), and Spinal cord (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAP1LC3A Gene



Protein tissue co-expression partners for MAP1LC3A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAP1LC3A Gene:

MAP1LC3A

SOURCE GeneReport for Unigene cluster for MAP1LC3A Gene:

Hs.632273

mRNA Expression by UniProt/SwissProt for MAP1LC3A Gene:

Q9H492-MLP3A_HUMAN
Tissue specificity: Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for MAP1LC3A Gene

  • Nervous system(4.6)
  • Muscle(2.1)
  • Liver(2)
genes like me logo Genes that share expression patterns with MAP1LC3A: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAP1LC3A Gene

Orthologs for MAP1LC3A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP1LC3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP1LC3A 34 35
  • 98.35 (n)
cow
(Bos Taurus)
Mammalia MAP1LC3A 34 35
  • 95.59 (n)
dog
(Canis familiaris)
Mammalia MAP1LC3A 34 35
  • 95.04 (n)
rat
(Rattus norvegicus)
Mammalia Map1lc3a 34
  • 93.39 (n)
mouse
(Mus musculus)
Mammalia Map1lc3a 34 16 35
  • 93.11 (n)
oppossum
(Monodelphis domestica)
Mammalia MAP1LC3A 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP1LC3A 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP1LC3A 34 35
  • 85.95 (n)
lizard
(Anolis carolinensis)
Reptilia MAP1LC3A 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia map1lc3a 34
  • 79.44 (n)
Str.13107 34
African clawed frog
(Xenopus laevis)
Amphibia map1lc3a-prov 34
zebrafish
(Danio rerio)
Actinopterygii map1lc3a 34 35
  • 81.11 (n)
wufc38e10 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8909 34
worm
(Caenorhabditis elegans)
Secernentea lgg-2 36 34 35
  • 55.85 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ATG8 35
  • 34 (a)
OneToMany
Species where no ortholog for MAP1LC3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP1LC3A Gene

ENSEMBL:
Gene Tree for MAP1LC3A (if available)
TreeFam:
Gene Tree for MAP1LC3A (if available)

Paralogs for MAP1LC3A Gene

Paralogs for MAP1LC3A Gene

(8) SIMAP similar genes for MAP1LC3A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MAP1LC3A: view

Variants for MAP1LC3A Gene

Sequence variations from dbSNP and Humsavar for MAP1LC3A Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000140497 -- 34,553,805(+) GGAAA(C/T)ATTTG intron-variant
rs1000356100 -- 34,556,878(+) TTACT(A/G)GCATG intron-variant, upstream-variant-2KB
rs1000785166 -- 34,545,016(+) CTCCT(C/T)TACGT upstream-variant-2KB
rs1000795569 -- 34,549,566(+) CGTTA(C/G)GGCTG intron-variant
rs1000834405 -- 34,556,318(+) TTGTC(A/G)TGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP1LC3A Gene

Variant ID Type Subtype PubMed ID
esv2666225 CNV deletion 23128226
nsv3359 CNV deletion 18451855

Variation tolerance for MAP1LC3A Gene

Residual Variation Intolerance Score: 48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP1LC3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAP1LC3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP1LC3A Gene

Disorders for MAP1LC3A Gene

MalaCards: The human disease database

(3) MalaCards diseases for MAP1LC3A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
nasu-hakola disease
  • polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
lacrimal gland adenocarcinoma
  • adenocarcinoma of lacrimal gland
leber congenital amaurosis 6
  • lca6
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MAP1LC3A

Human Genome Epidemiology (HuGE) Navigator
MAP1LC3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP1LC3A
genes like me logo Genes that share disorders with MAP1LC3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MAP1LC3A Gene

Publications for MAP1LC3A Gene

  1. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. (PMID: 17580304) Pankiv S. … Johansen T. (J. Biol. Chem. 2007) 2 3 4 64
  2. Regulation of endoplasmic reticulum turnover by selective autophagy. (PMID: 26040720) Khaminets A. … Dikic I. (Nature 2015) 3 4 64
  3. TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity. (PMID: 26347139) Kimura T. … Deretic V. (J. Cell Biol. 2015) 3 4 64
  4. TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. (PMID: 25127057) Mandell M.A. … Deretic V. (Dev. Cell 2014) 3 4 64
  5. Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism. (PMID: 24290141) Suzuki H. … Wakatsuki S. (Structure 2014) 3 4 64

Products for MAP1LC3A Gene

Sources for MAP1LC3A Gene

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