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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP1LC3A Gene

protein-coding   GIFtS: 56
GCID: GC20P033134

microtubule-associated protein 1 light chain 3 alpha

 Explore 22 diseases affiliated with
MAP1LC3A via our new
 Human Malady Compendium 
Biological research products
for MAP1LC3A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Microtubule-Associated Protein 1 Light Chain 3 Alpha1 2 3     MAP1 Light Chain 3-Like Protein 12 3
MAP1ALC31 2 5     MAP1A/MAP1B LC3 A2 3
MAP1BLC31 2 5     MAP1A/MAP1B Light Chain 3 A2 3
ATG8E1 2     MAP1A/1B Light Chain 3 A2
LC31 2     Microtubule-Associated Proteins 1A/1B Light Chain 32
LC3A1 2     Microtubule-Associated Proteins 1A/1B Light Chain 3A2
Autophagy-Related Ubiquitin-Like Modifier LC3 A2 3     Autophagy-Related Protein LC3 A3

External Ids:    HGNC: 68381   Entrez Gene: 845572   Ensembl: ENSG000001014607   OMIM: 6012425   UniProtKB: Q9H4923   

Export aliases for MAP1LC3A gene to outside databases

Previous GC identifers: GC20P032896 GC20P033806 GC20P033850 GC20P032598 GC20P029915


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAP1LC3A:
MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and
components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain
subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or
MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1
is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. (provided by RefSeq, Feb
2012)

UniProtKB/Swiss-Prot: MLP3A_HUMAN, Q9H492
Function: Involved in formation of autophagosomal vacuoles (autophagosomes)

Gene Wiki entry for MAP1LC3A


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP1LC3A gene promoter:
         ER-alpha   NF-1/L   NF-1   AML1a   Pax-6   MyoD   IRF-1   NF-Y   MRF-2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAP1LC3A promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP1LC3A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP1LC3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.22   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.22

MAP1LC3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP1LC3A gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P033134:  view genomic region     (about GC identifiers)

Start:
33,134,658 bp from pter      End:
33,148,149 bp from pter
Size:
13,492 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MLP3A_HUMAN, Q9H492 (See protein sequence)
Recommended Name: Microtubule-associated proteins 1A/1B light chain 3A precursor  
Size: 121 amino acids; 14272 Da
Subunit: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity).
Interacts with SQSTM1 (By similarity). Interacts with TP53INP1 and TP53INP2. Directly interacts with SQSTM1; this
interaction leads to MAP1LC3A recruitment to inclusion bodies containing polyubiquitinated protein aggregates and to
inclusion body degradation by autophagy
Subcellular location: Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome
membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome. Note=LC3-II binds to the autophagic membranes
1 PDB 3D structure from and Proteopedia for MAP1LC3A:
3ECI (3D)    
Secondary accessions: E1P5P4 E1P5P5 Q9BXW5
Alternative splicing: 2 isoforms:  Q9H492-1   Q9H492-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP1LC3A: NX_Q9H492

Post-translational modifications:

  • The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7,
  • transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H492

  • MAP1LC3A Protein expression data from MOPED and PaxDb:    About this image 
    MAP1LC3A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_115903.1  NP_852610.1  

    ENSEMBL proteins: 
     ENSP00000363970   ENSP00000353886   ENSP00000380821  

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    Browse Proteins at Uscn

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000421autophagic vacuole membrane IEA--
    GO:0005737cytoplasm ----
    GO:0005770late endosome IEA--
    GO:0005776autophagic vacuole IDA19056683
    GO:0005829cytosol IDA15187094

    MAP1LC3A for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MAP1LC3A for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004241 Atg8_ubiquitin-like

    Graphical View of Domain Structure for InterPro Entry Q9H492

    ProtoNet protein and cluster: Q9H492

    1 Blocks protein family: IPB004241 Light chain 3 (LC3)

    UniProtKB/Swiss-Prot: MLP3A_HUMAN, Q9H492
    Similarity: Belongs to the MAP1 LC3 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MLP3A_HUMAN, Q9H492
    Function: Involved in formation of autophagosomal vacuoles (autophagosomes)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005543phospholipid binding IDA15187094
    GO:0008429phosphatidylethanolamine binding IDA16303767
         
    MAP1LC3A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MAP1LC3A:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MAP1LC3A 

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Protein Stability
    Protein Stability1.00
    2Apoptosis and Autophagy
    Apoptosis and Autophagy1.00
    3Senescence and Autophagy
    Senescence and Autophagy1.00
    4Glucose / Energy Metabolism
    Glucose / Energy Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for MAP1LC3A
        Apoptosis and Autophagy
    Glucose / Energy Metabolism
    Protein Stability

    1 BioSystems Pathway for MAP1LC3A 
        Senescence and Autophagy



    MAP1LC3A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP1LC3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/504 Interacting proteins for MAP1LC3A (Q9H4921, 2, 3 ENSP000003639704) via UniProtKB, MINT, STRING, and/or I2D (see all 504)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NBR1Q145961, 2, 3, ENSP000003434794EBI-720768,EBI-2859623 MINT-7034375 MINT-7034418 MINT-7034400 I2D: score=3 STRING: ENSP00000343479
    SQSTM1Q135011, 2, 3, ENSP000003744554EBI-720768,EBI-307104 MINT-7034438 I2D: score=5 STRING: ENSP00000374455
    KIF15Q9NS872, 3, ENSP000003240204MINT-65629 I2D: score=5 STRING: ENSP00000324020
    RPL9P329693I2D: score=1 
    RPL9P7P329693I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly ISS--
    GO:0000422mitochondrion degradation IGI--
    GO:0006914autophagy ----

    MAP1LC3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Search CenterWatch for drugs/clinical trials and news about MAP1LC3A / MLP3A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAP1LC3A gene (2 alternative transcripts): 
    NM_032514.3  NM_181509.2  

    Unigene Cluster for MAP1LC3A:

    Microtubule-associated protein 1 light chain 3 alpha
    Hs.632273  [show with all ESTs]
    Unigene Representative Sequence: BM546695
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374837(uc002xap.1) ENST00000360668(uc002xaq.1) ENST00000397709
    ENST00000476428

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    hsa-miR-3678-3p hsa-miR-140-3p hsa-miR-3184 hsa-miR-3065-3p hsa-miR-1205 hsa-miR-423-5p hsa-miR-1184 hsa-miR-544
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    Additional cDNA sequence: 

    AF276658.1 AL833855.1 BC015810.1 BT007452.1 

    4 DOTS entries:

    DT.452785  DT.92421175  DT.95170349  DT.95170350 

    24/95 AceView cDNA sequences (see all 95):

    H18170 AW161970 AW161293 BM703791 CR597014 BM919877 BV167281 BM740344 
    BX115760 AA115532 BM919896 BC015810 BM665165 BM715386 BU783857 BE881349 
    AL833855 NM_181509 BM668783 BU732830 BM925959 BT007452 BI522709 AF276658 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MAP1LC3A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
    SP1:                    -     -     -                     
    SP2:                          -                           
    SP3:                                                      


    ECgene alternative splicing isoforms for MAP1LC3A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP1LC3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCCCCCCTA
    MAP1LC3A Expression
    About this image
    See MAP1LC3A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP1LC3A

    SOURCE GeneReport for Unigene cluster: Hs.632273

    UniProtKB/Swiss-Prot: MLP3A_HUMAN, Q9H492
    Tissue specificity: Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and
    peripheral blood leukocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAP1LC3A: 
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAP1LC3A gene from 9/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map1lc3a1 , 5 microtubule-associated protein 1 light chain 3 alpha1, 5 93.11(n)1
    100(a)1
      2 (77.18 cM)5
    667341  NM_025735.31  NP_080011.11 
     1552762975 
    chicken
    (Gallus gallus)
    Aves MAP1LC3A1 microtubule-associated protein 1 light chain 3 alpha 85.95(n)
    94.21(a)
      419142  XM_417327.3  XP_417327.2 
    lizard
    (Anolis carolinensis)
    Reptilia MAP1LC3A6
    --
    93(a)
    1 ↔ 1
    4(138206284-138222876)
    African clawed frog
    (Xenopus laevis)
    Amphibia map1lc3a-prov2 microtubule-associated protein 1 light chain 3 alpha 77.9(n)    BC043946.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc38e102 Transcribed sequence with strong similarity to protein more 81.37(n)    57052656 
    honey bee
    (Apis mellifera)
    Insecta --
    --
    59(a)
    1 → many
    Group2.12(671918-672669)
    worm
    (Caenorhabditis elegans)
    Secernentea lgg-21 , 3 microtubule-associated protein 1 like3
    Protein LGG-21
    59(a)3
    55.85(n)1
    59.65(a)1
      IV(10934632-10936290)3
    1779891  NM_069634.21  NP_502035.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATG8F6
    ATATG8E6
    (see all 7)
    autophagy-related protein 8e
    (see all 7)
    33(a)
    33(a)
    (see all 7)
    possible ortholog
    possible ortholog
    (see all 7)
    4(9306663-9308462)
    2(18624264-18625717)
    rice
    (Oryza sativa)
    Liliopsida Atg86
    --
    (see all 3)
    autophagy-related protein, putative, expressed
    (see all 3)
    34(a)
    34(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    7(19624532-19627300)
    4(31531261-31534066)


    ENSEMBL Gene Tree for MAP1LC3A (if available)
    TreeFam Gene Tree for MAP1LC3A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP1LC3A gene
    GABARAPL22  MAP1LC3B2  MAP1LC3C2  GABARAP2  GABARAPL32  MAP1LC3B22  GABARAPL12  
    8 SIMAP similar genes for MAP1LC3A using alignment to 1 protein entry:     MLP3A_HUMAN:
    DKFZp762B153    MAP1LC3B    MAP1LC3B2    MAP1LC3C    GABARAPL2    GABARAPL1
    GABARAPL3    GABARAP

    MAP1LC3A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/243 NCBI SNPs in MAP1LC3A are shown (see all 243    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1460223181,2
    C--33132832(+) GCAATC/TGGCCC 1 -- us2k10--------
    rs1141315831,2
    F--33132841(+) CCAGAG/AAATAT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1399799681,2
    --33132861(+) GGTCTA/CAGCAG 1 -- us2k10--------
    rs24249941,2
    C,F,H--33132917(+) AAATAC/TGTTAG 1 -- us2k124Minor allele frequency- T:0.25NS EA NA WA CSA 2765
    rs1817689871,2
    --33133120(+) GTGTGC/TGCCAC 1 -- us2k10--------
    rs802768671,2
    C--33133121(+) TGTGCA/GCCACC 1 -- us2k10--------
    rs60885211,2
    C,F,A,H--33133184(+) GCTAAA/CGCTGG 1 -- us2k121Minor allele frequency- C:0.35NS EA NA WA 2346
    rs1431490781,2
    --33133243(+) TGCTGA/GGATTA 1 -- us2k10--------
    rs1140352421,2
    F--33133276(+) GCATAT/ATTGAT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1461910241,2
    --33133395(+) GAAGTA/TACTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAP1LC3A (33134658 - 33148149 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MAP1LC3A: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MAP1LC3A for disorders           About GeneDecksing

    OMIM gene information: 601242    OMIM disorders: --

    20/22 diseases for MAP1LC3A (see all 22):    About MalaCards
    inclusion body myositis    granular cell tumor    chronic lymphocytic leukemia    myositis
    lymphocytic leukemia    cblc    laryngitis    laryngeal carcinoma
    melanoma metastasis    hepatitis c    huntington's disease    acute leukemia
    leukemia    dementia    nasopharyngitis    breast carcinoma
    melanoma    breast cancer    hepatitis    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: MAP1LC3A (1 document)

    Export disorders for MAP1LC3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP1LC3A gene, integrated from 9 sources (see all 96):
    (articles sorted by number of sources associating them with MAP1LC3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. (PubMed id 17580304)1, 2, 3 Pankiv S....Johansen T. (2007)
    2. The TP53INP2 protein is required for autophagy in mammalian cells. (PubMed id 19056683)1, 2 Nowak J....Iovanna J.L. (2009)
    3. HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. (PubMed id 15187094)1, 2 Tanida I....Kominami E. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. (PubMed id 12740394)1, 2 He H.... Yu L. (2003)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. Gene localization and developmental expression of light chain 3: a common subunit of microtubule-associated protein 1A(MAP1A) and MAP1B. (PubMed id 8833088)1, 3 Mann S.S. and Hammarback J.A. (1996)
    8. TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death. (PubMed id 22421968)2 Seillier M.... Dusetti N.J. (2012)
    9. Microtubule-associated protein 1 light chain 3 (LC3) i nteracts with Bnip3 protein to selectively remove endoplasmic reticulum and mito chondria via autophagy. (PubMed id 22505714)1 Hanna R.A....Gustafsson A.B. (2012)
    10. Rab GTPase-activating proteins in autophagy: regulatio n of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. (PubMed id 22354992)1 Popovic D....Dikic I. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84557 HGNC: 6838 AceView: MAP1LC3A Ensembl:ENSG00000101460 euGenes: HUgn84557
    ECgene: MAP1LC3A H-InvDB: MAP1LC3A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP1LC3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAP1LC3A gene:
    Search GeneIP for patents involving MAP1LC3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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