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MAP1LC3A Gene

protein-coding   GIFtS: 60
GCID: GC20P033134

Microtubule-Associated Protein 1 Light Chain 3 Alpha

  See MAP1LC3A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Microtubule-Associated Protein 1 Light Chain 3 Alpha1 2 3     ATG8E2
Autophagy-Related Ubiquitin-Like Modifier LC3 A2 3     LC32
MAP1 Light Chain 3-Like Protein 12 3     LC3A2
MAP1A/MAP1B LC3 A2 3     MAP1A/1B Light Chain 3 A2
MAP1A/MAP1B Light Chain 3 A2 3     Microtubule-Associated Proteins 1A/1B Light Chain 32
MAP1ALC32 5     Microtubule-Associated Proteins 1A/1B Light Chain 3A2
MAP1BLC32 5     Autophagy-Related Protein LC3 A3

External Ids:    HGNC: 68381   Entrez Gene: 845572   Ensembl: ENSG000001014607   OMIM: 6012425   UniProtKB: Q9H4923   

Export aliases for MAP1LC3A gene to outside databases

Previous GC identifers: GC20P032896 GC20P033806 GC20P033850 GC20P032598 GC20P029915


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAP1LC3A Gene:
MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules
and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light
chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either
MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression
of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. (provided
by RefSeq, Feb 2012)

GeneCards Summary for MAP1LC3A Gene:
MAP1LC3A (microtubule-associated protein 1 light chain 3 alpha) is a protein-coding gene. Diseases associated with MAP1LC3A include nephropathic cystinosis. GO annotations related to this gene include phosphatidylethanolamine binding and phospholipid binding. An important paralog of this gene is GABARAPL2.

UniProtKB/Swiss-Prot: MLP3A_HUMAN, Q9H492
Function: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s
are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later
stage in autophagosome maturation

Gene Wiki entry for MAP1LC3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP1LC3A gene promoter:
         ER-alpha   NF-1/L   NF-1   AML1a   Pax-6   MyoD   IRF-1   NF-Y   MRF-2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAP1LC3A promoter sequence
   Search Chromatin IP Primers for MAP1LC3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP1LC3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.22   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.22

MAP1LC3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP1LC3A gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P033134:  view genomic region     (about GC identifiers)

Start:
33,134,658 bp from pter      End:
33,148,149 bp from pter
Size:
13,492 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MLP3A_HUMAN, Q9H492 (See protein sequence)
Recommended Name: Microtubule-associated proteins 1A/1B light chain 3A precursor  
Size: 121 amino acids; 14272 Da
Subunit: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity).
Interacts with SQSTM1 (By similarity). Interacts with TP53INP1 and TP53INP2. Directly interacts with SQSTM1; this
interaction leads to MAP1LC3A recruitment to inclusion bodies containing polyubiquitinated protein aggregates and
to inclusion body degradation by autophagy. Interacts with ATG13 and ULK1
3 PDB 3D structures from and Proteopedia for MAP1LC3A:
3ECI (3D)        3WAL (3D)        3WAN (3D)    
Secondary accessions: E1P5P4 E1P5P5 Q9BXW5
Alternative splicing: 2 isoforms:  Q9H492-1   Q9H492-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAP1LC3A: NX_Q9H492

Explore proteomics data for MAP1LC3A at MOPED

Post-translational modifications: 

  • The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7,
    transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II1
  • The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to
    reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine1
  • Phosphorylation at Ser-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE). Interaction with MAPK15
    reduces the inhibitory phosphorylation and increases autophagy activity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MAP1LC3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_115903.1  NP_852610.1  

    ENSEMBL proteins: 
     ENSP00000363970   ENSP00000353886   ENSP00000380821  

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    Sino Biological Recombinant Protein for MAP1LC3A
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MAP1LC3A
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    antibodies-online proteins for MAP1LC3A (15 products) 

     
    antibodies-online peptides for MAP1LC3A

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004241 Atg8_like

    Graphical View of Domain Structure for InterPro Entry Q9H492

    ProtoNet protein and cluster: Q9H492

    1 Blocks protein domain: IPB004241 Light chain 3 (LC3)

    UniProtKB/Swiss-Prot: MLP3A_HUMAN, Q9H492
    Similarity: Belongs to the ATG8 family


    Find genes that share domains with MAP1LC3A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MLP3A_HUMAN, Q9H492
    Function: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s
    are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later
    stage in autophagosome maturation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11096062
    GO:0005543phospholipid binding IDA15187094
    GO:0008429phosphatidylethanolamine binding IDA16303767
         
    Find genes that share ontologies with MAP1LC3A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MAP1LC3A:
     Decreased Wnt reporter activit 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MAP1LC3A

    miRNA
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    miRTarBase miRNAs that target MAP1LC3A:
    hsa-mir-335-5p (MIRT018831)

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    SwitchGear 3'UTR luciferase reporter plasmidMAP1LC3A 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MLP3A_HUMAN, Q9H492: Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle,
    autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    vacuole5
    endosome2
    nucleus2
    lysosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000421autophagic vacuole membrane IEA--
    GO:0005737cytoplasm ----
    GO:0005770late endosome IEA--
    GO:0005776autophagic vacuole IDA12740394
    GO:0005829cytosol IDA15187094

    Find genes that share ontologies with MAP1LC3A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAP1LC3A About    
    See pathways by source

    SuperPathContained pathways About
    1Senescence and Autophagy
    Senescence and Autophagy


    1 BioSystems Pathway for MAP1LC3A
        Senescence and Autophagy



        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP1LC3A: 
              Autophagy in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAP1LC3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAP1LC3A (Q9H4921, 2, 3 ENSP000003639704) via UniProtKB, MINT, STRING, and/or I2D (see all 543)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    ENSG00000231555P081073I2D: score=2 
    ENSG00000232804P081073I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000045autophagic vacuole assembly ISS--
    GO:0000422mitochondrion degradation IGI--
    GO:0006914autophagy ----

    Find genes that share ontologies with MAP1LC3A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for MAP1LC3A (MLP3A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAP1LC3A gene (2 alternative transcripts): 
    NM_032514.3  NM_181509.2  

    Unigene Cluster for MAP1LC3A:

    Microtubule-associated protein 1 light chain 3 alpha
    Hs.632273  [show with all ESTs]
    Unigene Representative Sequence: BM546695
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374837(uc002xap.1) ENST00000360668(uc002xaq.1) ENST00000397709
    ENST00000476428
    miRNA
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    hsa-miR-3678-3p hsa-miR-140-3p hsa-miR-3184 hsa-miR-3065-3p hsa-miR-1205 hsa-miR-423-5p hsa-miR-1184 hsa-miR-544
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      QuantiFast Probe-based Assays in human, mouse, rat MAP1LC3A

    Additional mRNA sequence: 

    AF276658.1 AL833855.1 BC015810.1 BT007452.1 

    4 DOTS entries:

    DT.452785  DT.92421175  DT.95170349  DT.95170350 

    Selected AceView cDNA sequences (see all 95):

    CR597014 AW161970 BM703791 BM919877 AW161293 H18170 BM740344 BM668783 
    AW163154 NM_181509 BG715828 BI824755 AW449490 NM_032514 CA434672 BC015810 
    BM919896 AI146808 AW304934 AL833855 BU732830 AI088675 BM924606 AF276658 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MAP1LC3A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
    SP1:                    -     -     -                     
    SP2:                          -                           
    SP3:                                                      


    ECgene alternative splicing isoforms for MAP1LC3A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAP1LC3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCCCCCTA
    MAP1LC3A Expression
    About this image


    MAP1LC3A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    MAP1LC3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP1LC3A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632273

    UniProtKB/Swiss-Prot: MLP3A_HUMAN, Q9H492
    Tissue specificity: Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and
    peripheral blood leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAP1LC3A: 
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              Cell Death PathwayFinder in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP1LC3A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAP1LC3A gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map1lc3a1 , 5 microtubule-associated protein 1 light chain 3 alpha1, 5 93.11(n)1
    100(a)1
      2 (77.18 cM)5
    667341  NM_025735.31  NP_080011.11 
     1552762975 
    chicken
    (Gallus gallus)
    Aves MAP1LC3A1 microtubule-associated protein 1 light chain 3 alpha 85.95(n)
    94.21(a)
      419142  XM_417327.4  XP_417327.2 
    lizard
    (Anolis carolinensis)
    Reptilia MAP1LC3A6
    microtubule-associated protein 1 light chain 3 alp...
    86(a)
    1 ↔ 1
    4(138184500-138223679)
    African clawed frog
    (Xenopus laevis)
    Amphibia map1lc3a-prov2 microtubule-associated protein 1 light chain 3 alpha 77.9(n)    BC043946.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc38e102 Transcribed sequence with strong similarity to protein more 81.37(n)    57052656 
    worm
    (Caenorhabditis elegans)
    Secernentea lgg-21 , 3 microtubule-associated protein 1 like3
    lgg-21
    59(a)3
    55.85(n)1
    59.65(a)1
      IV(10934632-10936290)3
    1779891  NM_001268594.11  NP_001255523.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ATG86
    Component of autophagosomes and Cvt vesicles; unde...
    34(a)
    1 → many
    II(80378-80731) YBL078C


    ENSEMBL Gene Tree for MAP1LC3A (if available)
    TreeFam Gene Tree for MAP1LC3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAP1LC3A gene
    GABARAPL22  MAP1LC3B2  GABARAP2  MAP1LC3C2  GABARAPL32  MAP1LC3B22  GABARAPL12  
    8 SIMAP similar genes for MAP1LC3A using alignment to 1 protein entry:     MLP3A_HUMAN:
    DKFZp762B153    MAP1LC3B    MAP1LC3B2    MAP1LC3C    GABARAPL2    GABARAPL1
    GABARAPL3    GABARAP

    Find genes that share paralogs with MAP1LC3A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAP1LC3A (see all 278)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1460223181,2
    C--33132832(+) GCAATC/TGGCCC 1 -- us2k10--------
    rs1141315831,2
    F--33132841(+) CCAGAG/AAATAT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1399799681,2
    --33132861(+) GGTCTA/CAGCAG 1 -- us2k10--------
    rs24249941,2
    C,F,H--33132917(+) AAATAC/TGTTAG 1 -- us2k124Minor allele frequency- T:0.25NS EA NA WA CSA 2765
    rs3714019531,2
    C--33132984(+) GGCAGC/G/TGGGGT 1 -- us2k10--------
    rs1817689871,2
    --33133120(+) GTGTGC/TGCCAC 1 -- us2k10--------
    rs802768671,2
    C--33133121(+) TGTGCA/GCCACC 1 -- us2k10--------
    rs60885211,2
    C,F,A,H--33133184(+) GCTAAA/CGCTGG 1 -- us2k121Minor allele frequency- C:0.35NS EA NA WA 2346
    rs1431490781,2
    --33133243(+) TGCTGA/GGATTA 1 -- us2k10--------
    rs1140352421,2
    C,F--33133276(+) GCATAT/ATTGAT 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for MAP1LC3A (33134658 - 33148149 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MAP1LC3A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666225CNV Deletion23128226
    nsv3359CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP1LC3A
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP1LC3A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601242    OMIM disorders: --

    1 disease for MAP1LC3A:    
    About MalaCards
    nephropathic cystinosis


    Find genes that share disorders with MAP1LC3A           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: MAP1LC3A (1 document)

    Export disorders for MAP1LC3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAP1LC3A gene, integrated from 10 sources (see all 123):
    (articles sorted by number of sources associating them with MAP1LC3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. (PubMed id 17580304)1, 2, 3 Pankiv S.... Johansen T. (J. Biol. Chem. 2007)
    2. TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death. (PubMed id 22421968)1, 2 Seillier M.... Dusetti N.J. (Cell Death Differ. 2012)
    3. ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs. (PubMed id 23043107)1, 2 Alemu E.A.... Johansen T. (J. Biol. Chem. 2012)
    4. Regulation of the autophagy protein LC3 by phosphorylation. (PubMed id 20713600)1, 2 Cherra S.J. III... Chu C.T. (J. Cell Biol. 2010)
    5. The TP53INP2 protein is required for autophagy in mammalian cells. (PubMed id 19056683)1, 2 Nowak J.... Iovanna J.L. (Mol. Biol. Cell 2009)
    6. HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. (PubMed id 15187094)1, 2 Tanida I....Kominami E. (J. Biol. Chem. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. (PubMed id 12740394)1, 2 He H.... Yu L. (J. Biol. Chem. 2003)
    9. The human homolog of Saccharomyces cerevisiae Apg7p is a Protein- activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3. (PubMed id 11096062)1, 2 Tanida I.... Kominami E. (J. Biol. Chem. 2001)
    10. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84557 HGNC: 6838 AceView: MAP1LC3A Ensembl:ENSG00000101460 euGenes: HUgn84557
    ECgene: MAP1LC3A H-InvDB: MAP1LC3A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAP1LC3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAP1LC3A gene:
    Search GeneIP for patents involving MAP1LC3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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