Aliases for MAP1B Gene
External Ids for MAP1B Gene
Previous GeneCards Identifiers for MAP1B Gene
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAP1B Gene
MAP1B (Microtubule Associated Protein 1B) is a Protein Coding gene. Diseases associated with MAP1B include Giant Axonal Neuropathy and Spinal Muscular Atrophy. Among its related pathways are Reelin signaling pathway and Lissencephaly gene (LIS1) in neuronal migration and development. GO annotations related to this gene include structural molecule activity and microtubule binding. An important paralog of this gene is MAP1A.
UniProtKB/Swiss-Prot for MAP1B Gene
Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.