Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MAP1B Gene

protein-coding   GIFtS: 63
GCID: GC05P071438

Microtubule-Associated Protein 1B

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Microtubule-Associated Protein 1B1 2
MAP-1B2 3
FUTSCH2
MAP52

External Ids:    HGNC: 68361   Entrez Gene: 41312   Ensembl: ENSG000001317117   OMIM: 1571295   UniProtKB: P468213   

Export aliases for MAP1B gene to outside databases

Previous GC identifers: GC05P070208 GC05P071636 GC05P071441 GC05P071487 GC05P066608


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MAP1B Gene:
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family
are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of
this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B
heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene
suggested an important role in development and function of the nervous system. (provided by RefSeq, Jul 2008)

GeneCards Summary for MAP1B Gene:
MAP1B (microtubule-associated protein 1B) is a protein-coding gene. Diseases associated with MAP1B include tick infestation, and proximal spinal muscular atrophy. GO annotations related to this gene include hydrolase activity and structural molecule activity. An important paralog of this gene is MAP1S.

UniProtKB/Swiss-Prot: MAP1B_HUMAN, P46821
Function: Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B
may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least
two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule
polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle
formation and membrane blebbing

Gene Wiki entry for MAP1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAP1B gene promoter:
         SRY   FOXC1   FOXJ2 (long isoform)   AP-2beta   FOXJ2   AP-2alpha   AP-2gamma   POU3F2   AP-2alphaA   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAP1B promoter sequence
   Search Chromatin IP Primers for MAP1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q13

MAP1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP1B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P071438:  view genomic region     (about GC identifiers)

Start:
71,403,061 bp from pter      End:
71,505,397 bp from pter
Size:
102,337 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MAP1B_HUMAN, P46821 (See protein sequence)
Recommended Name: Microtubule-associated protein 1B  
Size: 2468 amino acids; 270634 Da
Subunit: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. LC1 interacts
with the amino-terminal region of MAP1B. Interacts with ANP32A and TIAM2. Interacts with the tubulin tyrosine TTL
(By similarity). Interacts (via C-terminus) with GAN (via Kelch domains). Interacts (via N-terminus) with DAPK1.
Interacts with TMEM185A. Interacts with MAP1LC3B
Secondary accessions: A2BDK5

Explore the universe of human proteins at neXtProt for MAP1B: NX_P46821

Explore proteomics data for MAP1B at MOPED

Post-translational modifications: 

  • LC1 is generated from MAP1B by proteolytic processing1
  • S-nitrosylation at Cys-2464 enhances interaction with microtubules, and may act as an effector modification for
    neuronal nitric oxide synthase control of growth-cone size, growth-cone collapse and axon retraction (By
    similarity)1
  • Ubiquitination2 at Lys1908, Lys1976
  • Modification sites at PhosphoSitePlus

  • See MAP1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005900.2  
    ENSEMBL proteins: 
     ENSP00000426312   ENSP00000296755   ENSP00000427194   ENSP00000423444   ENSP00000423416  

    MAP1B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MAP1B
    GenScript Custom Purified and Recombinant Proteins Services for MAP1B
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAP1B

    MAP1B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP1B
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MAP1B
    OriGene Custom Antibody Services for MAP1B
    Novus Biologicals MAP1B Antibodies
    Abcam antibodies for MAP1B
    Cloud-Clone Corp. Antibodies for MAP1B
    ThermoFisher Antibody for MAP1B
    Search LSBio for Antibodies for MAP1B

    MAP1B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAP1B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAP1B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAP1B
    Cloud-Clone Corp. CLIAs for MAP1B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR027321 MAP1B
     IPR000102 MAP1B_neuraxin
     IPR026074 MAP1
     IPR001279 Beta-lactamas-like

    Graphical View of Domain Structure for InterPro Entry P46821

    ProtoNet protein and cluster: P46821

    UniProtKB/Swiss-Prot: MAP1B_HUMAN, P46821
    Domain: Has a highly basic region with many copies of the sequence KKEE and KKEI/V, repeated but not at fixed
    intervals, which is responsible for the binding of MAP1B to microtubules
    Similarity: Belongs to the MAP1 family


    MAP1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAP1B_HUMAN, P46821
    Function: Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B
    may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least
    two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule
    polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle
    formation and membrane blebbing

         Genatlas biochemistry entry for MAP1B:
    microtubule associated protein 1B (320kDa),coexpressed with GABRR1 at postsynaptic sites on bipolar cell axon
    terminals,in retina,involved in neurite outgrow,expressed in forming neurons

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity NAS1881920
    GO:0005515protein binding IPI12147674
    GO:0008017microtubule binding IEA--
    GO:0016787hydrolase activity IEA--
         
    MAP1B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MAP1B:
     Decreased G3BP1 protein expres  Increased HPV18 LCR reporter a 

         10 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Map1b):
     behavior/neurological  cellular  growth/size/body  homeostasis/metabolism  integument 
     limbs/digits/tail  mortality/aging  nervous system  reproductive system  vision/eye 

    MAP1B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for MAP1B: Map1btm1Rak Map1btm1Prop Map1btm1Noh

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAP1B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAP1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP1B

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAP1B:
    hsa-mir-92a-3p (MIRT049003), hsa-mir-9-5p (MIRT021367), hsa-mir-455-3p (MIRT037842), hsa-mir-222-3p (MIRT046647), hsa-mir-132-3p (MIRT021755), hsa-mir-7-5p (MIRT025635), hsa-mir-34a-5p (MIRT025245), hsa-mir-30d-5p (MIRT047808)

    Block miRNA regulation of human, mouse, rat MAP1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP1B (see all 98):
    hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-520e hsa-miR-607 hsa-miR-519a hsa-miR-550a* hsa-miR-298 hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmidMAP1B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAP1B
    Predesigned siRNA for gene silencing in human, mouse, rat MAP1B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAP1B

    Clone
    Products:
         
    OriGene clones in human, mouse for MAP1B (see all 5)
    OriGene ORF clones in mouse, rat for MAP1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAP1B (NM_005909)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP1B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAP1B
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAP1B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MAP1B_HUMAN, P46821: Cytoplasm, cytoskeleton. Cytoplasm. Cell junction, synapse (By similarity). Cell projection,
    dendritic spine (By similarity). Note=Colocalizes with DAPK1 in the microtubules and cortical actin fibers (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane4
    cytosol3
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IEA--
    GO:0005874microtubule IEA--
    GO:0005875microtubule associated complex TAS1881920
    GO:0005886plasma membrane IDA19567321

    MAP1B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MAP1B About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TGF-Beta Pathway
    JNK Pathway0.51
    2Wnt signaling pathway (KEGG)
    Wnt Signaling Pathway NetPath0.37
    3Synaptic transmission ion currents
    Synaptic transmission ion currents
    4Regulation of Microtubule Cytoskeleton
    Regulation of Microtubule Cytoskeleton
    5Reelin signaling pathway
    Reelin signaling pathway

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MAP1B
        JNK Pathway

    4 BioSystems Pathways for MAP1B
        Wnt Signaling Pathway NetPath
    Lissencephaly gene (LIS1) in neuronal migration and development
    Reelin signaling pathway
    Regulation of Microtubule Cytoskeleton


        Pathway & Disease-focused RT2 Profiler PCR Array including MAP1B: 
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAP1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAP1B (P468211, 2, 3 ENSP000002967554) via UniProtKB, MINT, STRING, and/or I2D (see all 183)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046371, 2, 3, ENSP000002693054EBI-764611,EBI-366083 MINT-6700861 MINT-6701791 MINT-6702529 MINT-6701342 MINT-6702266 MINT-6706444 I2D: score=1 STRING: ENSP00000269305
    GANQ9H2C01, 3EBI-764611,EBI-764342 I2D: score=4 
    ATG12O948173, ENSP000002744594I2D: score=3 STRING: ENSP00000274459
    ATG3Q9NT623, ENSP000002832904I2D: score=3 STRING: ENSP00000283290
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=3 STRING: ENSP00000363970
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization ----
    GO:0001578microtubule bundle formation IEA--
    GO:0007409axonogenesis ----
    GO:0009987cellular process IDA19567321
    GO:0016358dendrite development IEA--

    MAP1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAP1B

    Selected Novoseek inferred chemical compound relationships for MAP1B gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nocodazole 55.4 2 10504342 (1), 9813091 (1)
    glycogen 32.7 11 9589389 (3), 12932442 (1), 16949836 (1), 11739659 (1) (see all 7)
    betamethasone 24.6 2 11158279 (1), 12562943 (1)
    dbc-amp 17.3 1 7803854 (1)
    paclitaxel 17 2 15907802 (1), 9813091 (1)
    lithium 16.5 4 9570753 (3), 9589389 (1)
    silver 9.22 1 12562943 (1)
    threonine 7.02 1 15737742 (1)
    oligonucleotide 5.68 1 9044056 (1)
    calcium 2.5 2 16234245 (1), 12927206 (1)



    MAP1B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MAP1B gene (2 alternative transcripts): 
    NM_032010.1  NM_005909.3  

    Unigene Cluster for MAP1B:

    Microtubule-associated protein 1B
    Hs.335079  [show with all ESTs]
    Unigene Representative Sequence: NM_005909
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512974 ENST00000296755(uc010iyw.1 uc010iyx.1 uc003kbw.4 uc010iyy.1)
    ENST00000504183 ENST00000513526 ENST00000511641 ENST00000504492

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MAP1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAP1B (see all 98):
    hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-520e hsa-miR-607 hsa-miR-519a hsa-miR-550a* hsa-miR-298 hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmidMAP1B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MAP1B
    Predesigned siRNA for gene silencing in human, mouse, rat MAP1B
    Clone
    Products:
         
    OriGene clones in human, mouse for MAP1B (see all 5)
    OriGene ORF clones in mouse, rat for MAP1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAP1B (NM_005909)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP1B
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MAP1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAP1B
      QuantiTect SYBR Green Assays in human, mouse, rat MAP1B
      QuantiFast Probe-based Assays in human, mouse, rat MAP1B

    Additional mRNA sequence: 

    AF085863.1 AK055112.1 AK096273.1 AK125194.1 AK307990.1 AK308147.1 BC017240.2 BC025240.1 
    BC032516.1 BC033486.1 BC039822.1 BC046114.1 BC047027.1 BC056145.1 BC062464.1 BC063669.1 
    BC073993.1 BC094834.1 BC108733.1 BC139918.1 BC141853.1 BC150196.1 BX647077.1 CR933720.1 
    Y09836.1 

    22 DOTS entries:

    DT.40267580  DT.100724215  DT.95352259  DT.97773055  DT.100828073  DT.95177364  DT.97862087  DT.120836192 
    DT.100033985  DT.97804781  DT.120836055  DT.92450902  DT.92450927  DT.95075786  DT.100828066  DT.95072999 
    DT.95075787  DT.95075798  DT.95374515  DT.91968748  DT.95072996  DT.97781359 

    Selected AceView cDNA sequences (see all 751):

    BE257538 BQ884155 T33729 AA975155 BU154786 BC056145 D58271 BM714877 
    CB114581 AA983563 CR619734 AA564108 AA668503 AL537096 AA708290 AA628853 
    BM749998 BX372603 CR601693 BC017240 AI192664 F02710 BU735751 AA814706 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAP1B (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
    SP1:                          -                       -                                                   
    SP2:                          -     -                                                                     
    SP3:                          -     -                 -                                                   
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for MAP1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MAP1B expression in normal human tissues (normalized intensities)      MAP1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCCCCTCT
    MAP1B Expression
    About this image


    MAP1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 5 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
             Islets of Langerhans
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cushion Mesenchymal Cells Endocardium
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
    MAP1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAP1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.335079
        Pathway & Disease-focused RT2 Profiler PCR Array including MAP1B: 
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MAP1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAP1B
    QuantiTect SYBR Green Assays in human, mouse, rat MAP1B
    QuantiFast Probe-based Assays in human, mouse, rat MAP1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MAP1B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map1b1 , 5 microtubule-associated protein 1B1, 5 85.69(n)1
    89.93(a)1
      13 (52.90 cM)5
    177551  NM_008634.21  NP_032660.21 
     994214645 
    chicken
    (Gallus gallus)
    Aves MAP1B6
    microtubule-associated protein 1B
    72(a)
    1 ↔ 1
    Z(25184265-25251593)
    lizard
    (Anolis carolinensis)
    Reptilia MAP1B6
    microtubule-associated protein 1B
    73(a)
    1 ↔ 1
    2(16522473-16605181)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.84472 Xenopus laevis transcribed sequence with moderate similarity more 78.35(n)    AW158276.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.294182 Transcribed sequence with weak similarity to protein more 75.03(n)    AL722241.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta futsch3 axonogenesis microtubule binding 31(a)   2A3   --


    ENSEMBL Gene Tree for MAP1B (if available)
    TreeFam Gene Tree for MAP1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MAP1B gene
    MAP1S2  MAP1A2  
    3 SIMAP similar genes for MAP1B using alignment to 13 protein entries:     MAP1B_HUMAN (see all proteins):
    DKFZp686F1345    MAP1A    MAP1S

    MAP1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MAP1B (see all 2004)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360164
    A colorectal cancer sample4--see VAR_0360162 R Q mis40--------
    VAR_0360174
    A colorectal cancer sample4--see VAR_0360172 V M mis40--------
    rs1875259421,2
    --66606550(+) CATCCA/CATCTT 1 -- us2k10--------
    rs1146583591,2
    C,F--71401155(+) TGTTAG/ATATCT 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1404428311,2
    --71401194(+) TCTCTA/GTTTTC 1 -- us2k10--------
    rs1504156681,2
    --71401204(+) CAACCA/GAGAAA 1 -- us2k10--------
    rs1921079321,2
    --71401208(+) CAAGAA/GAGGAG 1 -- us2k10--------
    rs1823922261,2
    --71401415(+) TTACAC/TACATA 1 -- us2k10--------
    rs1124420741,2
    F--71401417(+) ACATAC/TATAAA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1383023761,2
    C--71401481(+) ATCCAA/TCGGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAP1B (71403061 - 71505397 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MAP1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv268202CNV Insertion20981092
    esv269233CNV Insertion20981092
    nsv823097CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAP1B
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 157129    OMIM disorders: --

    Selected diseases for MAP1B (see all 27):    About MalaCards
    tick infestation    proximal spinal muscular atrophy    werdnig-hoffmann disease    fragile x syndrome
    olivopontocerebellar atrophy    spinal muscular atrophy    muscular atrophy    lissencephaly
    multiple system atrophy    tuberous sclerosis    intellectual disability    schizophrenia
    alzheimer's disease    mental retardation    bipolar disorder    ischemia
    neuropathy    neuroblastoma    breast and colorectal cancer    parkinson's disease

    5 diseases from the University of Copenhagen DISEASES database for MAP1B:
    Fragile X syndrome     Werdnig-Hoffmann disease     Tick infestation     Muscular atrophy
    Intellectual disability

    MAP1B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for MAP1B gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neuropathy, giant axonal 83.7 1 15528209 (1)
    muscular atrophy spinal 66.9 5 1881920 (2), 1505990 (2), 8449502 (1)
    paired helical filament 64 3 1591102 (1), 1630577 (1)
    fragile x syndrome 54.9 1 12927206 (1)
    olivopontocerebellar atrophies 54.3 1 1517758 (1)
    neurodegenerative diseases 54.1 2 12376528 (1)
    neurofibrillary tangles 53 4 17032350 (1), 1909079 (1), 2361014 (1)
    alzheimers disease 44.2 6 9589389 (2), 1909079 (1), 2361014 (1), 7854037 (1)
    mental retardation 39.8 1 15528209 (1)
    senile plaques 25.3 2 17032350 (1), 1909079 (1)

    Genetic Association Database (GAD): MAP1B
    Human Genome Epidemiology (HuGE) Navigator: MAP1B (1 document)

    Export disorders for MAP1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MAP1B gene, integrated from 10 sources (see all 226):
    (articles sorted by number of sources associating them with MAP1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing. (PubMed id 18195017)1, 2, 9 Harrison B.... Hupp T.R. (J. Biol. Chem. 2008)
    2. Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15. (PubMed id 7806212)1, 2, 9 Lien L.L.... Kunkel L.M. (Genomics 1994)
    3. Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin. (PubMed id 12147674)1, 2, 9 Ding J....Yang Y. (J. Cell Biol. 2002)
    4. Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13. (PubMed id 1881920)1, 3, 9 Lien L.L....Kunkel L.M. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    5. Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival. (PubMed id 16227972)1, 2, 9 Allen E.... Yang Y. (Nature 2005)
    6. Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3'-untranslated region. (PubMed id 12684070)1, 2, 9 Dergunova L.V.... Limborska S.A. (Biomol. Eng. 2003)
    7. Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. (PubMed id 19054571)1, 4 GregA^rio S.P....Dias-Neto E. (Psychiatry Res 2009)
    8. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)1, 4 Lesch K.P....Jacob C. (J Neural Transm 2008)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    10. Novel features of the light chain of microtubule-associated protein MAP1B: microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain. (PubMed id 9813091)1, 9 TAPgel M....Propst F. (J. Cell Biol. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4131 HGNC: 6836 AceView: MAP1B Ensembl:ENSG00000131711 euGenes: HUgn4131
    ECgene: MAP1B H-InvDB: MAP1B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MAP1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP1B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MAP1B gene:
    Search GeneIP for patents involving MAP1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of MAP1B
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MAP1B   OriGene RNAi products in human, mouse, rat for MAP1B  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MAP1B  
     OriGene qSTAR qPCR primer pairs in human, mouse for MAP1B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MAP1B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MAP1B   OriGene Custom Protein Services for MAP1B  

     
     
     Block miRNA regulation of human, mouse, rat MAP1B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MAP1B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAP1B Predesigned siRNA for gene silencing in human, mouse, rat MAP1B
     QuantiFast Probe-based Assays in human, mouse, rat MAP1B QuantiTect SYBR Green Assays in human, mouse, rat MAP1B
     PCR Arrays including human, mouse, rat MAP1B Search Chromatin IP Primers for MAP1B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAP1B  GeneGlobe Interaction Network for MAP1B
     Regulatory tfbs in MAP1B promoter
     GenScript Custom Purified and Recombinant Proteins Services for MAP1B GenScript cDNA clones with any tag delivered in your preferred vector for MAP1B
     GenScript Custom Assay Services for MAP1B GenScript Custom overexpressing Cell Line Services for MAP1B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MAP1B
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MAP1B antibodies
     Antibodies for MAP1B
     See all of Abcam's Antibodies, Kits and Proteins for MAP1B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MAP1B
     Antibodies for MAP1B
     ELISAs for MAP1B
     CLIAs for MAP1B



     Browse ESI BIO Cell Lines and PureStem Progenitors for MAP1B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP1B
     SwitchGear 3'UTR luciferase reporter plasmids for MAP1B
     SwitchGear Promoter luciferase reporter plasmids for MAP1B
     ThermoFisher Antibody for MAP1B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAP1B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAP1B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAP1B
     Search LSBio for Antibodies for MAP1B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MAP1B gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4