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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP1B Gene

protein-coding   GIFtS: 60
GCID: GC05P071438

microtubule-associated protein 1B
 Explore 21 diseases affiliated with
MAP1B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAP1B    

Aliases
for MAP1B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Microtubule-Associated Protein 1B1 2
MAP51 2
MAP-1B2 3
FUTSCH2

External Ids:    HGNC: 68361   Entrez Gene: 41312   Ensembl: ENSG000001317117   OMIM: 1571295   UniProtKB: P468213   

Export aliases for MAP1B gene to outside databases

Previous GC identifers: GC05P070208 GC05P071636 GC05P071441 GC05P071487 GC05P066608


Summaries
for MAP1B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAP1B:
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are
thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene
is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain
and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important
role in development and function of the nervous system. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MAP1B_HUMAN, P46821
Function: Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may
play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B Binds to at least two tubulin
subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and
in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane
blebbing

Gene Wiki entry for MAP1B


Genomic Views
for MAP1B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP1B gene promoter:
         SRY   FOXC1   FOXJ2 (long isoform)   AP-2beta   FOXJ2   AP-2alpha   AP-2gamma   POU3F2   AP-2alphaA   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAP1B promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q13

MAP1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP1B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P071438:  view genomic region     (about GC identifiers)

Start:
 71,403,061 bp from pter      End:
 71,505,397 bp from pter
Size:
 102,337 bases      Orientation:
 plus strand

Proteins
for MAP1B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MAP1B_HUMAN, P46821 (See protein sequence)
Recommended Name: Microtubule-associated protein 1B  
Size: 2468 amino acids; 270634 Da
Subunit: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. LC1 interacts with
the amino-terminal region of MAP1B. Interacts with ANP32A and TIAM2. Interacts with the tubulin tyrosine TTL (By
similarity). Interacts (via C-terminus) with GAN (via Kelch domains). Interacts (via N-terminus) with DAPK1
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm. Cell junction, synapse (By similarity). Cell projection,
dendritic spine (By similarity). Note=Colocalizes with DAPK1 in the microtubules and cortical actin fibers (By
similarity)
Secondary accessions: A2BDK5

Explore the universe of human proteins at neXtProt for MAP1B: NX_P46821

Post-translational modifications:

  • LC1 is generated from MAP1B by proteolytic processing1
  • S-nitrosylation at Cys-2464 enhances interaction with microtubules, and may act as an effector modification for
    • neuronal nitric oxide synthase control of growth-cone size, growth-cone collapse and axon retraction (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P46821

    • MAP1B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005900.2  
    ENSEMBL proteins: 
     ENSP00000426312   ENSP00000296755   ENSP00000427194   ENSP00000423444   ENSP00000423416  

    Human Recombinant Protein Products: 
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    Uscn Proteins for MAP1B

    Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005829cytosol IEA--
    GO:0005856cytoskeleton ----
    GO:0005874microtubule IEA--
    GO:0005875microtubule associated complex IEA--


    MAP1B for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for MAP1B

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    Uscn ELISAs and CLIAs for MAP1B

    Protein Domains /
    Families
    for MAP1B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAP1B for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000102 MAP1B_neuraxin
     IPR026074 MAP1

    Graphical View of Domain Structure for InterPro Entry P46821

    ProtoNet protein and cluster: P46821

    UniProtKB/Swiss-Prot: MAP1B_HUMAN, P46821
    Domain: Has a highly basic region with many copies of the sequence KKEE and KKEI/V, repeated but not at fixed
    intervals, which is responsible for the binding of MAP1B to microtubules
    Similarity: Belongs to the MAP1 family


    Function
    for MAP1B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MAP1B_HUMAN, P46821
    Function: Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may
    play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B Binds to at least two tubulin
    subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and
    in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane
    blebbing

         Genatlas biochemistry entry for MAP1B:
    microtubule associated protein 1B (320kDa),coexpressed with GABRR1 at postsynaptic sites on bipolar cell axon
    terminals,in retina,involved in neurite outgrow,expressed in forming neurons

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP1B
    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP1B (see all 98):
    hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-520e hsa-miR-607 hsa-miR-519a hsa-miR-550a* hsa-miR-298 hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmid: MAP1B 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP1B (see all 7)
    OriGene shRNA RFP: MAP1B
    OriGene siRNA: MAP1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP1B

    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding ----
    GO:0005198structural molecule activity NAS1881920
    GO:0005515protein binding IPI12147674
    GO:0008017microtubule binding ----
    GO:0032403protein complex binding ----


    MAP1B for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MAP1B:
     Decreased G3BP1 protein expres  Increased HPV18 LCR reporter a 

    Animal Models:
         Mouse knock-outs for MAP1B: Map1btm1Rak Map1btm1Prop Map1btm1Noh
         10 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Map1b):
     behavior/neurological  cellular  growth/size  homeostasis/metabolism  integument 
     limbs/digits/tail  mortality/aging  nervous system  reproductive system  vision/eye 

    MAP1B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAP1B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Synaptic transmission: ion currents
    		Synaptic transmission: ion currents1.00
    2Lissencephaly gene (LIS1) in neuronal migration and development
    		Lissencephaly gene (LIS1) in neuronal migration and development1.00
    3Reelin signaling pathway
    		Reelin signaling pathway1.00
    4TGF-Beta Pathway
    		JNK Pathway0.50
    5Wnt Signaling Pathway
    		Wnt Signaling Pathway NetPath0.22

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for MAP1B
        Synaptic transmission- ion currents

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MAP1B
        JNK Pathway

    3 BioSystems Pathways for MAP1B 
        Wnt Signaling Pathway NetPath
    Lissencephaly gene (LIS1) in neuronal migration and development
    Reelin signaling pathway



    MAP1B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/81 Interacting proteins for MAP1B (P468211, 2, 3 ENSP000002967554) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046372, 3, ENSP000002693054MINT-6700861 MINT-6701791 MINT-6702529 MINT-6701342 MINT-6702266 MINT-6706444 I2D: score=1 STRING: ENSP00000269305
    GANQ9H2C01, 3, ENSP000002482724EBI-764611,EBI-764342 I2D: score=4 STRING: ENSP00000248272
    ATG12O948173, ENSP000002744594I2D: score=3 STRING: ENSP00000274459
    ATG3Q9NT623, ENSP000002832904I2D: score=3 STRING: ENSP00000283290
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=3 STRING: ENSP00000363970
    About this table

    Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001578microtubule bundle formation IEA--
    GO:0007026negative regulation of microtubule depolymerization ----
    GO:0007399nervous system development ----
    GO:0007409axonogenesis ----
    GO:0007416synapse assembly ----


    MAP1B for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAP1B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP1B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP1B
    10/16 Novoseek chemical compound relationships for MAP1B gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nocodazole 55.4 2 10504342 (1), 9813091 (1)
    glycogen 32.7 11 9589389 (3), 12932442 (1), 16949836 (1), 11739659 (1) (see all 7)
    betamethasone 24.6 2 11158279 (1), 12562943 (1)
    dbc-amp 17.3 1 7803854 (1)
    paclitaxel 17 2 15907802 (1), 9813091 (1)
    lithium 16.5 4 9570753 (3), 9589389 (1)
    silver 9.22 1 12562943 (1)
    threonine 7.02 1 15737742 (1)
    oligonucleotide 5.68 1 9044056 (1)
    calcium 2.5 2 16234245 (1), 12927206 (1)

    Search CenterWatch for drugs/clinical trials and news about MAP1B 

    Transcripts
    for MAP1B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAP1B gene (2 alternative transcripts): 
    NM_032010.1  NM_005909.3  

    Unigene Cluster for MAP1B:

    Microtubule-associated protein 1B
    Hs.335079  [show with all ESTs]
    Unigene Representative Sequence: NM_005909
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512974 ENST00000296755(uc010iyw.1 uc010iyx.1 uc003kbw.4 uc010iyy.1)
    ENST00000504183 ENST00000513526 ENST00000511641 ENST00000504492

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP1B
    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP1B (see all 98):
    hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-520e hsa-miR-607 hsa-miR-519a hsa-miR-550a* hsa-miR-298 hsa-miR-1243
    SwitchGear 3'UTR luciferase reporter plasmid: MAP1B 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP1B (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF085863.1 AK055112.1 AK096273.1 AK125194.1 AK307990.1 AK308147.1 BC017240.2 BC025240.1 
    BC032516.1 BC033486.1 BC039822.1 BC046114.1 BC047027.1 BC056145.1 BC062464.1 BC063669.1 
    BC073993.1 BC094834.1 BC108733.1 BC139918.1 BC141853.1 BC150196.1 BX647077.1 CR933720.1 
    Y09836.1 

    21 DOTS entries:

    DT.40267580  DT.100724215  DT.95352259  DT.97773055  DT.95177364  DT.100828073  DT.97862087  DT.120836192 
    DT.100033985  DT.97804781  DT.120836055  DT.92450902  DT.92450927  DT.100828066  DT.95075786  DT.95075787 
    DT.95075798  DT.95374515  DT.91968748  DT.95072996  DT.97781359 

    24/751 AceView cDNA sequences (see all 751):

    CB160207 BE255082 AI963096 AA670382 AL120414 BE257538 AA111983 BU154786 
    BC063669 AA083718 T31163 AW205395 BM450418 AA425667 CA388626 BU146719 
    BM711326 AA708290 BU628876 AI418955 AA814706 BM684616 BF059198 BC033486 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MAP1B (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
    SP1:                          -                       -                                                   
    SP2:                          -     -                                                                     
    SP3:                          -     -                 -                                                   
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for MAP1B

    Expression
    for MAP1B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGCCCCTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAP1B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    EyeRetinaEye
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MAP1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP1B

    SOURCE GeneReport for Unigene cluster: Hs.335079
        SABiosciences Expression via Pathway-Focused PCR Array including MAP1B: 
              Epithelial to Mesenchymal Transition (EMT) in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP1B

    Orthologs
    for MAP1B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MAP1B gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Map1b5
    Mtap1b1    		 microtubule-associated protein 1B1, 5 86.19(n)1
    91.22(a)1    		   13 (52.90 cM)5
    177551  NM_008634.21  NP_032660.21 
     994214645 
    chicken
    (Gallus gallus)    		 Aves MAP1B1 microtubule-associated protein 1B 73.59(n)
    76.3(a)    		   396174  XM_001231728.2  XP_001231729.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MAP1B6
    		 --
    		 72(a)
    		 1 ↔ 1
    		 2(16522473-16544698)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.84472 Xenopus laevis transcribed sequence with moderate similarity more 78.35(n)    AW158276.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.294182 Transcribed sequence with weak similarity to protein more 75.03(n)    AL722241.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea F32A7.56
    F25D7.46
    (see all 3)    		 --
    		 19(a)
    19(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 I(14846467-14850315)
    I(10418225-10421851)


    ENSEMBL Gene Tree for MAP1B (if available)
    TreeFam Gene Tree for MAP1B (if available) 

    Paralogs
    for MAP1B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP1B gene
    AKAP122  MAP1S2  MAP1A2  
    3 SIMAP similar genes for MAP1B using alignment to 13 protein entries:     MAP1B_HUMAN (see all proteins):
    DKFZp686F1345    MAP1A    MAP1S

    MAP1B for paralogs           About GeneDecksing



    Genomic Variants
    for MAP1B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1712 NCBI SNPs in MAP1B are shown (see all 1712)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1146583591,2
    		C,F,--71401155(+) TGTTAG/ATATCT 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1404428311,2
    		--71401194(+) TCTCTA/GTTTTC 1 -- us2k10--------
    rs1504156681,2
    		--71401204(+) CAACCA/GAGAAA 1 -- us2k10--------
    rs1921079321,2
    		--71401208(+) CAAGAA/GAGGAG 1 -- us2k10--------
    rs1823922261,2
    		--71401415(+) TTACAC/TACATA 1 -- us2k10--------
    rs1124420741,2
    		--71401417(+) ACATAC/TATAAA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1383023761,2
    		--71401481(+) ATCCAA/TCGGAT 1 -- us2k10--------
    rs38225501,2
    		C,F,--71401525(+) CCTGCC/TCCTCA 1 -- us2k19Minor allele frequency- T:0.20WA NA CSA EA 369
    rs757699061,2
    		C,--71401531(+) CCTCAC/TCCCAG 1 -- us2k12Minor allele frequency- T:0.15WA 120
    rs1441078241,2
    		--71401544(+) ATGGGC/GTTTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAP1B (71403061 - 71505397 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MAP1B: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAP1B
    DNA2.0 Custom Variant and Variant Library Synthesis for MAP1B

    Disorders / Diseases
    for MAP1B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAP1B for disorders           About GeneDecksing

    OMIM gene information: 157129    OMIM disorders: --

    20/21 diseases for MAP1B (see all 21):    About MalaCards
    proximal spinal muscular atrophy    spinal muscular atrophy    werdnig-hoffmann disease    fragile x syndrome
    olivopontocerebellar atrophy    muscular atrophy    tick infestation    multiple system atrophy
    intellectual disability    tuberous sclerosis    neurodegenerative disease    bipolar disorder
    alzheimer's disease    neurodegeneration    adhd    parkinson's disease
    schizophrenia    neuroblastoma    retinitis    malaria

    4 diseases from the University of Copenhagen DISEASES database for MAP1B:
    Fragile X syndrome     Tick infestation     Muscular atrophy     Intellectual disability

    10/16 Novoseek disease relationships for MAP1B gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neuropathy, giant axonal 83.7 1 15528209 (1)
    muscular atrophy spinal 66.9 5 1881920 (2), 1505990 (2), 8449502 (1)
    paired helical filament 64 3 1591102 (1), 1630577 (1)
    fragile x syndrome 54.9 1 12927206 (1)
    olivopontocerebellar atrophies 54.3 1 1517758 (1)
    neurodegenerative diseases 54.1 2 12376528 (1)
    neurofibrillary tangles 53 4 17032350 (1), 1909079 (1), 2361014 (1)
    alzheimers disease 44.2 6 9589389 (2), 1909079 (1), 2361014 (1), 7854037 (1)
    mental retardation 39.8 1 15528209 (1)
    senile plaques 25.3 2 17032350 (1), 1909079 (1)

    Human Genome Epidemiology (HuGE) Navigator: MAP1B (1 document)

    Export disorders for MAP1B gene to outside databases

    Publications
    for MAP1B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP1B gene, integrated from 9 sources (see all 215):
    (articles sorted by number of sources associating them with MAP1B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing. (PubMed id 18195017)1, 2, 9 Harrison B....Hupp T.R. (2008)
    2. Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15. (PubMed id 7806212)1, 2, 9 Lien L.L.... Kunkel L.M. (1994)
    3. Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin. (PubMed id 12147674)1, 2, 9 Ding J....Yang Y. (2002)
    4. Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13. (PubMed id 1881920)1, 3, 9 Lien L.L....Kunkel L.M. (1991)
    5. Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival. (PubMed id 16227972)1, 2, 9 Allen E....Yang Y. (2005)
    6. Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3'-untranslated region. (PubMed id 12684070)1, 2, 9 Dergunova L.V.... Limborska S.A. (2003)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. Novel features of the light chain of microtubule-associated protein MAP1B: microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain. (PubMed id 9813091)1, 9 Togel M....Propst F. (1998)
    9. Microtubule-associated protein 1b, a neuronal marker involved in odontoblast differentiation. (PubMed id 19567321)1, 9 Maurin J.C....Bleicher F. (2009)
    10. Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein. (PubMed id 11733546)1, 9 Franzen R....Quarles R.H. (2001)

    External Searches for MAP1B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAP1B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4131 HGNC: 6836 AceView: MAP1B Ensembl:ENSG00000131711 euGenes: HUgn4131
    ECgene: MAP1B H-InvDB: MAP1B

    Other Databases showing MAP1B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAP1B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAP1B Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MAP1B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAP1B gene:
    Search GeneIP for patents involving MAP1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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