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Aliases for MAP1B Gene

Aliases for MAP1B Gene

  • Microtubule-Associated Protein 1B 2 3
  • MAP-1B 3 4
  • Protein Phosphatase 1, Regulatory Subunit 102 3
  • Regulatory Subunit 102 2
  • Protein Phosphatase 1 2
  • PPP1R102 3
  • FUTSCH 3
  • MAP5 3

External Ids for MAP1B Gene

Previous GeneCards Identifiers for MAP1B Gene

  • GC05P070208
  • GC05P071636
  • GC05P071441
  • GC05P071487
  • GC05P071438
  • GC05P066608

Summaries for MAP1B Gene

Entrez Gene Summary for MAP1B Gene

  • This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP1B Gene

MAP1B (Microtubule-Associated Protein 1B) is a Protein Coding gene. Diseases associated with MAP1B include tick infestation and olivopontocerebellar atrophy. Among its related pathways are TGF-Beta Pathway and Reelin signaling pathway. GO annotations related to this gene include structural molecule activity and hydrolase activity. An important paralog of this gene is MAP1A.

UniProtKB/Swiss-Prot for MAP1B Gene

  • Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.

Gene Wiki entry for MAP1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP1B Gene

Genomics for MAP1B Gene

Regulatory Elements for MAP1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAP1B Gene

Start:
72,107,234 bp from pter
End:
72,209,570 bp from pter
Size:
102,337 bases
Orientation:
Plus strand

Genomic View for MAP1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP1B Gene

Proteins for MAP1B Gene

  • Protein details for MAP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P46821-MAP1B_HUMAN
    Recommended name:
    Microtubule-associated protein 1B
    Protein Accession:
    P46821
    Secondary Accessions:
    • A2BDK5

    Protein attributes for MAP1B Gene

    Size:
    2468 amino acids
    Molecular mass:
    270634 Da
    Quaternary structure:
    • 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. LC1 interacts with the amino-terminal region of MAP1B. Interacts with ANP32A and TIAM2. Interacts with the tubulin tyrosine TTL (By similarity). Interacts (via C-terminus) with GAN (via Kelch domains). Interacts (via N-terminus) with DAPK1. Interacts with TMEM185A. Interacts with MAP1LC3B.

neXtProt entry for MAP1B Gene

Proteomics data for MAP1B Gene at MOPED

Post-translational modifications for MAP1B Gene

  • LC1 is generated from MAP1B by proteolytic processing.
  • S-nitrosylation at Cys-2464 enhances interaction with microtubules, and may act as an effector modification for neuronal nitric oxide synthase control of growth-cone size, growth-cone collapse and axon retraction.
  • Ubiquitination at Lys1908 and Lys1976
  • Modification sites at PhosphoSitePlus

Other Protein References for MAP1B Gene

No data available for DME Specific Peptides for MAP1B Gene

Domains for MAP1B Gene

Protein Domains for MAP1B Gene

Graphical View of Domain Structure for InterPro Entry

P46821

UniProtKB/Swiss-Prot:

MAP1B_HUMAN :
  • P46821
Domain:
  • Has a highly basic region with many copies of the sequence KKEE and KKEI/V, repeated but not at fixed intervals, which is responsible for the binding of MAP1B to microtubules
Family:
  • Belongs to the MAP1 family.
genes like me logo Genes that share domains with MAP1B: view

No data available for Gene Families for MAP1B Gene

Function for MAP1B Gene

Molecular function for MAP1B Gene

GENATLAS Biochemistry: microtubule associated protein 1B (320kDa),coexpressed with GABRR1 at postsynaptic sites on bipolar cell axon terminals,in retina,involved in neurite outgrow,expressed in forming neurons
UniProtKB/Swiss-Prot Function: Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.

Gene Ontology (GO) - Molecular Function for MAP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity NAS 1881920
GO:0005515 protein binding IPI 12147674
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with MAP1B: view
genes like me logo Genes that share phenotypes with MAP1B: view

Animal Models for MAP1B Gene

MGI Knock Outs for MAP1B:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MAP1B Gene

Localization for MAP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP1B Gene

Cytoplasm, cytoskeleton. Cytoplasm. Cell junction, synapse. Cell projection, dendritic spine. Note=Colocalizes with DAPK1 in the microtubules and cortical actin fibers. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP1B Gene COMPARTMENTS Subcellular localization image for MAP1B gene
Compartment Confidence
cytoskeleton 5
plasma membrane 4
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for MAP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IEA --
GO:0005874 microtubule IEA --
GO:0005875 microtubule associated complex TAS 1881920
GO:0005886 plasma membrane IDA 19567321
genes like me logo Genes that share ontologies with MAP1B: view

Pathways for MAP1B Gene

genes like me logo Genes that share pathways with MAP1B: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MAP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization --
GO:0001578 microtubule bundle formation IEA --
GO:0007399 nervous system development --
GO:0007409 axonogenesis --
GO:0009987 cellular process IDA 19567321
genes like me logo Genes that share ontologies with MAP1B: view

Compounds for MAP1B Gene

(16) Novoseek inferred chemical compound relationships for MAP1B Gene

Compound -log(P) Hits PubMed IDs
nocodazole 55.4 2
glycogen 32.7 9
betamethasone 24.6 2
dbc-amp 17.3 1
paclitaxel 17 2
genes like me logo Genes that share compounds with MAP1B: view

Transcripts for MAP1B Gene

Unigene Clusters for MAP1B Gene

Microtubule-associated protein 1B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP1B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MAP1B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP1B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - -
SP2: - -
SP3: - - -
SP4:
SP5:
SP6:

Relevant External Links for MAP1B Gene

GeneLoc Exon Structure for
MAP1B
ECgene alternative splicing isoforms for
MAP1B

Expression for MAP1B Gene

mRNA expression in normal human tissues for MAP1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP1B Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP1B Gene

SOURCE GeneReport for Unigene cluster for MAP1B Gene Hs.335079

genes like me logo Genes that share expressions with MAP1B: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MAP1B Gene

Orthologs for MAP1B Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP1B 35
  • 99.66 (n)
  • 99.72 (a)
MAP1B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAP1B 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP1B 35
  • 87.88 (n)
  • 91.1 (a)
MAP1B 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map1b 35
  • 85.69 (n)
  • 89.93 (a)
Map1b 16
Map1b 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP1B 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAP1B 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map1b 35
  • 84.39 (n)
  • 89.09 (a)
chicken
(Gallus gallus)
Aves MAP1B 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP1B 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8447 35
zebrafish
(Danio rerio)
Actinopterygii Dr.29418 35
MAP1B 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta dp 36
  • 3 (a)
ManyToMany
futsch 36
  • 11 (a)
ManyToMany
futsch 37
  • 31 (a)
Species with no ortholog for MAP1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP1B Gene

ENSEMBL:
Gene Tree for MAP1B (if available)
TreeFam:
Gene Tree for MAP1B (if available)

Paralogs for MAP1B Gene

Paralogs for MAP1B Gene

genes like me logo Genes that share paralogs with MAP1B: view

Variants for MAP1B Gene

Sequence variations from dbSNP and Humsavar for MAP1B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs12096 -- 72,209,393(-) TGATG(A/C)AGGAT utr-variant-3-prime
rs930391 -- 72,207,860(-) GTTCA(G/T)GTTAA utr-variant-3-prime
rs1051214 -- 72,209,541(+) GTTCC(A/C)CAATA utr-variant-3-prime
rs1079383 -- 72,161,201(-) CAAAC(C/T)CACAT intron-variant
rs1123161 -- 72,116,386(+) TCTGA(C/T)ATTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP1B Gene

Variant ID Type Subtype PubMed ID
esv269233 CNV Insertion 20981092
esv268202 CNV Insertion 20981092
nsv823097 CNV Gain 20364138

Relevant External Links for MAP1B Gene

HapMap Linkage Disequilibrium report
MAP1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP1B Gene

Disorders for MAP1B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MAP1B Gene including...

Search for MAP1B Gene in MalaCards »

(16) Novoseek inferred disease relationships for MAP1B Gene

Disease -log(P) Hits PubMed IDs
neuropathy, giant axonal 83.7 1
muscular atrophy spinal 66.9 5
paired helical filament 64 2
fragile x syndrome 54.9 1
olivopontocerebellar atrophies 54.3 1

Relevant External Links for MAP1B

Genetic Association Database (GAD)
MAP1B
Human Genome Epidemiology (HuGE) Navigator
MAP1B
genes like me logo Genes that share disorders with MAP1B: view

No data available for UniProtKB/Swiss-Prot for MAP1B Gene

Publications for MAP1B Gene

  1. Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15. (PMID: 7806212) Lien L.L. … Kunkel L.M. (Genomics 1994) 3 4 23
  2. Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13. (PMID: 1881920) Lien L.L. … Kunkel L.M. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 23
  3. Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3'-untranslated region. (PMID: 12684070) Dergunova L.V. … Limborska S.A. (Biomol. Eng. 2003) 3 4 23
  4. Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival. (PMID: 16227972) Allen E. … Yang Y. (Nature 2005) 3 4 23
  5. DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing. (PMID: 18195017) Harrison B. … Hupp T.R. (J. Biol. Chem. 2008) 3 4 23

Products for MAP1B Gene

Sources for MAP1B Gene

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