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Aliases for MAP1A Gene

Aliases for MAP1A Gene

  • Microtubule Associated Protein 1A 2 3 5
  • Proliferation-Related Protein P80 3 4
  • MAP-1A 3 4
  • MAP1L 3 4
  • EC 2.7.2.8 63
  • EC 6.3.4.5 63
  • MTAP1A 3

External Ids for MAP1A Gene

Previous HGNC Symbols for MAP1A Gene

  • MAP1L

Previous GeneCards Identifiers for MAP1A Gene

  • GC15P039180
  • GC15P036705
  • GC15P041382
  • GC15P041528
  • GC15P041525
  • GC15P041597
  • GC15P043803
  • GC15P020657

Summaries for MAP1A Gene

Entrez Gene Summary for MAP1A Gene

  • This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP1A Gene

MAP1A (Microtubule Associated Protein 1A) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity and microtubule binding. An important paralog of this gene is MAP1S.

UniProtKB/Swiss-Prot for MAP1A Gene

  • Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.

Gene Wiki entry for MAP1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP1A Gene

Genomics for MAP1A Gene

Regulatory Elements for MAP1A Gene

Enhancers for MAP1A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAP1A on UCSC Golden Path with GeneCards custom track

Promoters for MAP1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAP1A on UCSC Golden Path with GeneCards custom track

Genomic Location for MAP1A Gene

Chromosome:
15
Start:
43,510,958 bp from pter
End:
43,531,620 bp from pter
Size:
20,663 bases
Orientation:
Plus strand

Genomic View for MAP1A Gene

Genes around MAP1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP1A Gene

Proteins for MAP1A Gene

  • Protein details for MAP1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78559-MAP1A_HUMAN
    Recommended name:
    Microtubule-associated protein 1A
    Protein Accession:
    P78559
    Secondary Accessions:
    • O95643
    • Q12973
    • Q15882
    • Q9UJT4

    Protein attributes for MAP1A Gene

    Size:
    2803 amino acids
    Molecular mass:
    305485 Da
    Quaternary structure:
    • 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with TIAM2. Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG4. Binds to CSNK1D (By similarity).

    Alternative splice isoforms for MAP1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP1A Gene

Proteomics data for MAP1A Gene at MOPED

Selected DME Specific Peptides for MAP1A Gene

Post-translational modifications for MAP1A Gene

Other Protein References for MAP1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MAP1A Gene

Protein Domains for MAP1A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MAP1A Gene

Graphical View of Domain Structure for InterPro Entry

P78559

UniProtKB/Swiss-Prot:

MAP1A_HUMAN :
  • The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules.
  • Belongs to the MAP1 family.
Domain:
  • The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules.
Family:
  • Belongs to the MAP1 family.
genes like me logo Genes that share domains with MAP1A: view

No data available for Gene Families for MAP1A Gene

Function for MAP1A Gene

Molecular function for MAP1A Gene

GENATLAS Biochemistry:
microtubule associated protein 1A,306kDa
UniProtKB/Swiss-Prot Function:
Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.

Enzyme Numbers (IUBMB) for MAP1A Gene

Gene Ontology (GO) - Molecular Function for MAP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with MAP1A: view
genes like me logo Genes that share phenotypes with MAP1A: view

Animal Model Products

miRNA for MAP1A Gene

miRTarBase miRNAs that target MAP1A

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP1A Gene

Localization for MAP1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP1A Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP1A Gene COMPARTMENTS Subcellular localization image for MAP1A gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3
lysosome 2
vacuole 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for MAP1A Gene

Pathways & Interactions for MAP1A Gene

SuperPathways for MAP1A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007026 negative regulation of microtubule depolymerization IEA --
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
GO:0098792 xenophagy IMP 22020285
genes like me logo Genes that share ontologies with MAP1A: view

No data available for Pathways by source and SIGNOR curated interactions for MAP1A Gene

Drugs & Compounds for MAP1A Gene

(2) Drugs for MAP1A Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Estramustine Approved Pharma Target, antagonist 53
genes like me logo Genes that share compounds with MAP1A: view

Transcripts for MAP1A Gene

mRNA/cDNA for MAP1A Gene

Unigene Clusters for MAP1A Gene

Microtubule-associated protein 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP1A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2:
SP3: - - -
SP4:
SP5: - - - - - - - - -

Relevant External Links for MAP1A Gene

GeneLoc Exon Structure for
MAP1A
ECgene alternative splicing isoforms for
MAP1A

Expression for MAP1A Gene

mRNA expression in normal human tissues for MAP1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP1A Gene

This gene is overexpressed in Brain - Cortex (x5.8), Brain - Frontal Cortex (BA9) (x5.7), Brain - Anterior cingulate cortex (BA24) (x5.4), Brain - Amygdala (x4.3), and Brain - Hippocampus (x4.0).

Protein differential expression in normal tissues from HIPED for MAP1A Gene

This gene is overexpressed in Frontal cortex (36.1), Brain (13.2), and Spinal cord (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP1A Gene



SOURCE GeneReport for Unigene cluster for MAP1A Gene Hs.194301

mRNA Expression by UniProt/SwissProt for MAP1A Gene

P78559-MAP1A_HUMAN
Tissue specificity: Brain.
genes like me logo Genes that share expression patterns with MAP1A: view

Protein tissue co-expression partners for MAP1A Gene

Primer Products

Orthologs for MAP1A Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAP1A 35
  • 85.7 (n)
  • 84.8 (a)
MAP1A 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP1A 35
  • 88.31 (n)
  • 86.29 (a)
MAP1A 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map1a 35
  • 83.1 (n)
  • 81.76 (a)
Map1a 16
Map1a 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAP1A 35
  • 99.58 (n)
  • 99.36 (a)
MAP1A 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map1a 35
  • 82.42 (n)
  • 81.24 (a)
oppossum
(Monodelphis domestica)
Mammalia MAP1A 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP1A 35
  • 59.76 (n)
  • 58.29 (a)
MAP1A 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP1A 36
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii map1aa 36
  • 56 (a)
OneToMany
map1ab 36
  • 26 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta futsch 37
  • 37 (a)
dp 36
  • 3 (a)
ManyToMany
futsch 36
  • 12 (a)
ManyToMany
Species with no ortholog for MAP1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP1A Gene

ENSEMBL:
Gene Tree for MAP1A (if available)
TreeFam:
Gene Tree for MAP1A (if available)

Paralogs for MAP1A Gene

Paralogs for MAP1A Gene

(3) SIMAP similar genes for MAP1A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MAP1A: view

Variants for MAP1A Gene

Sequence variations from dbSNP and Humsavar for MAP1A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs2584695 - 43,521,689(+) TGTTT(G/T)TGGAA reference, missense
rs1060935 - 43,522,476(+) AGTTG(G/T)CCAAA reference, missense
rs1060936 - 43,522,480(+) GGCCA(A/C)ACGGG reference, missense
rs1060937 - 43,522,530(+) AGCTG(A/G/T)CCAAG reference, missense
rs1060938 - 43,522,542(+) AGTTA(G/T)CCAAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MAP1A Gene

Variant ID Type Subtype PubMed ID
nsv437799 CNV Loss 16327808
nsv515877 CNV Loss 19592680
nsv518707 CNV Loss 19592680
nsv832988 CNV Loss 17160897
nsv428304 CNV Loss 18775914
dgv741e1 CNV Complex 17122850
dgv742e1 CNV Complex 17122850

Variation tolerance for MAP1A Gene

Residual Variation Intolerance Score: 58.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.76; 97.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP1A Gene

HapMap Linkage Disequilibrium report
MAP1A
Human Gene Mutation Database (HGMD)
MAP1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP1A Gene

Disorders for MAP1A Gene

Relevant External Links for MAP1A

Genetic Association Database (GAD)
MAP1A
Human Genome Epidemiology (HuGE) Navigator
MAP1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP1A

No disorders were found for MAP1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP1A Gene

Publications for MAP1A Gene

  1. Brain-specific expression of human microtubule-associated protein 1A (MAP1A) gene and its assignment to human chromosome 15. (PMID: 7629894) Fukuyama R. … Rapoport S.I. (J. Neurosci. Res. 1995) 2 3 4 23 67
  2. Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15. (PMID: 7806212) Lien L.L. … Kunkel L.M. (Genomics 1994) 2 3 23
  3. MAP1A light chain 2 interacts with exchange protein activated by cyclic AMP 1 (EPAC1) to enhance Rap1 GTPase activity and cell adhesion. (PMID: 15591041) Gupta M. … Yarwood S.J. (J. Biol. Chem. 2005) 3 23
  4. Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A. (PMID: 15202935) Magiera M.M. … Yarwood S.J. (Biochem. J. 2004) 3 23
  5. Direct interaction between BKCa potassium channel and microtubule-associated protein 1A. (PMID: 15251455) Park S.M. … Marx S.O. (FEBS Lett. 2004) 3 23

Products for MAP1A Gene

Sources for MAP1A Gene

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