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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP1A Gene

protein-coding   GIFtS: 58
GCID: GC15P043803

Microtubule-Associated Protein 1A


(Previous symbol: MAP1L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Microtubule-Associated Protein 1A1 2     MTAP1A2
MAP1L1 2 3 5     EC 2.7.2.88
Proliferation-Related Protein P802 3     EC 6.3.4.58
MAP-1A2 3     

External Ids:    HGNC: 68351   Entrez Gene: 41302   Ensembl: ENSG000001669637   OMIM: 6001785   UniProtKB: P785593   

Export aliases for MAP1A gene to outside databases

Previous GC identifers: GC15P039180 GC15P036705 GC15P041382 GC15P041528 GC15P041525 GC15P041597 GC15P020657


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAP1A Gene:
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family
are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of
this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A
heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat
microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. (provided by
RefSeq, Jul 2008)

GeneCards Summary for MAP1A Gene: 
MAP1A (microtubule-associated protein 1A) is a protein-coding gene. Diseases associated with MAP1A include transient cerebral ischemia, and paraplegia. GO annotations related to this gene include protein binding and structural molecule activity. An important paralog of this gene is MAP1B.

UniProtKB/Swiss-Prot: MAP1A_HUMAN, P78559
Function: Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal
elements

Gene Wiki entry for MAP1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP1A gene promoter:
         AREB6   LHX3b/Lhx3b   GATA-3   MAZR   NRSF form 1   ATF-2   LHX3a/Lhx3a   c-Jun   NRSF form 2   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAP1A promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.3   Ensembl cytogenetic band:  15q15.3   HGNC cytogenetic band: 15q15.3

MAP1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP1A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P043803:  view genomic region     (about GC identifiers)

Start:
43,803,156 bp from pter      End:
43,823,818 bp from pter
Size:
20,663 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MAP1A_HUMAN, P78559 (See protein sequence)
Recommended Name: Microtubule-associated protein 1A  
Size: 2803 amino acids; 305485 Da
Subunit: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with
TIAM2. Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG4. Binds to CSNK1D (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (Probable)
Secondary accessions: O95643 Q12973 Q15882 Q9UJT4
Alternative splicing: 2 isoforms:  P78559-1   P78559-2   (Ref.1 (AAB41132/AAB41133) sequences are in conflict in positions: 2753:S->V, 2754:V->K)

Explore the universe of human proteins at neXtProt for MAP1A: NX_P78559

Explore proteomics data for MAP1A at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by CSNK1D (By similarity)
  • UniProtKB: LC2 is generated from MAP1A by proteolytic processing
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P78559

  • 2 DME Specific Peptides for MAP1A (P78559)
     GVGRLDM  PVISSVA 

    MAP1A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAP1A Protein Expression
    REFSEQ proteins: NP_002364.5  
    ENSEMBL proteins: 
     ENSP00000371462   ENSP00000300231   ENSP00000382380  

    Human Recombinant Protein Products for MAP1A: 
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    OriGene Custom Protein Services for MAP1A
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAP1A 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--
    GO:0005874microtubule IEA--
    GO:0005875microtubule associated complex TAS8812494

    MAP1A for ontologies           About GeneDecksing



    MAP1A Antibody Products: 
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    Cloud-Clone Corp. Antibodies for MAP1A 
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    Assay Products for MAP1A: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAP1A 
    Cloud-Clone Corp. CLIAs for MAP1A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR026074 MAP1
     IPR015656 MAP1A
     IPR001279 Beta-lactamas-like

    Graphical View of Domain Structure for InterPro Entry P78559

    ProtoNet protein and cluster: P78559

    UniProtKB/Swiss-Prot: MAP1A_HUMAN, P78559
    Domain: The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules
    Similarity: Belongs to the MAP1 family


    MAP1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAP1A_HUMAN, P78559
    Function: Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal
    elements

         Genatlas biochemistry entry for MAP1A:
    microtubule associated protein 1A,306kDa

         Enzyme Numbers (IUBMB): EC 6.3.4.52 EC 2.7.2.82

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity NAS8812494
    GO:0005515protein binding IPI12812986
    GO:0008017microtubule binding IEA--
    GO:0016787hydrolase activity IEA--
         
    MAP1A for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Map1a):
     hearing/vestibular/ear 

    MAP1A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAP1A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAP1A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAP1A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAP1A 

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAP1A:
    hsa-mir-338-3p (MIRT003040)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP1A
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP1A (see all 59):
    hsa-miR-3678-3p hsa-miR-330-5p hsa-miR-15a hsa-miR-449a hsa-miR-1273d hsa-miR-424 hsa-miR-1276 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidMAP1A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAP1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP1A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAP1A


    Clone
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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP1A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for MAP1A (P785591, 2, 3 ENSP000003002314) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DISC1Q9NRI51, 3, ENSP000003555964EBI-929047,EBI-529989 I2D: score=4 STRING: ENSP00000355596
    ENSG00000183311P074373I2D: score=1 
    ENSG00000224156P074373I2D: score=1 
    ENSG00000227739P074373I2D: score=1 
    ENSG00000229684P074373I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0007605sensory perception of sound IEA--

    MAP1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP1A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP1A

    1 DrugBank Compound for MAP1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    EstramustineEstramustin Sodium Phosphate (see all 4)2998-57-4targetantagonist1647395

    1 Novoseek inferred chemical compound relationship for MAP1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 1 16234245 (1)

    Search CenterWatch for drugs/clinical trials and news about MAP1A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAP1A gene: 
    NM_002373.5  

    Unigene Cluster for MAP1A:

    Microtubule-associated protein 1A
    Hs.194301  [show with all ESTs]
    Unigene Representative Sequence: NM_002373
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382031 ENST00000300231 ENST00000399453(uc001zrt.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP1A
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP1A (see all 59):
    hsa-miR-3678-3p hsa-miR-330-5p hsa-miR-15a hsa-miR-449a hsa-miR-1273d hsa-miR-424 hsa-miR-1276 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidMAP1A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MAP1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP1A
    Clone
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    OriGene clones in human, mouse for MAP1A (see all 8)
    OriGene ORF clones in mouse, rat for MAP1A
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAP1A
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MAP1A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAP1A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP1A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP1A

    Additional mRNA sequence: 

    AF095910.1 AF200415.2 AK291052.1 BC010470.1 BC055312.1 BC094702.1 BC104426.1 BC104427.1 
    U14577.1 U38292.1 U80458.1 

    8 DOTS entries:

    DT.97819905  DT.97800085  DT.453939  DT.92055239  DT.95278232  DT.121036320  DT.91877406  DT.92055638 

    24/179 AceView cDNA sequences (see all 179):

    BP361589 CR594234 BF059045 BQ636712 BX645642 AL118989 NM_002373 CA432109 
    BQ719408 CA431563 AW138764 BP349474 AL533374 CA390989 AW889891 CA432822 
    BC010470 BM905805 BP361547 AF200415 BF363434 BX493477 CA393760 BX418029 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MAP1A    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                                        -                                             
    SP2:                                                                                                      
    SP3:                                      -     -           -                                             
    SP4:                                                                                                      
    SP5:                          -     -     -     -     -     -     -     -     -                           


    ECgene alternative splicing isoforms for MAP1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP1A expression in normal human tissues (normalized intensities)      MAP1A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGCTTGCC
    MAP1A Expression
    About this image


    MAP1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
             Temporal Lobe   
     
     Epithelium (Reproductive System)    fully expand to see all 4 entries
             vagina ; squamous epithelial cells   
     
     Fibroblast
             skin ; fibroblasts   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             epididymis ; glandular cells   
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Islets of Langerhans
             pancreas ; exocrine glandular cells   

    See MAP1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP1A

    SOURCE GeneReport for Unigene cluster: Hs.194301

    UniProtKB/Swiss-Prot: MAP1A_HUMAN, P78559
    Tissue specificity: Brain

        SABiosciences Custom PCR Arrays for MAP1A
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP1A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MAP1A gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Map1a5
    Mtap1a1
    microtubule-associated protein 1 A1, 5 82.93(n)1
    81.55(a)1
      2 (60.37 cM)5
    177541  NM_032393.21  NP_115769.11 
     1212896005 
    chicken
    (Gallus gallus)
    Aves MAP1A1 microtubule-associated protein 1A 57.21(n)
    53.44(a)
      415588  XM_003641838.1  XP_003641886.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAP1A6
    Uncharacterized protein
    40(a)
    1 ↔ 1
    AAWZ02036659(6827-23920)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7975451 uncharacterized LOC797545 51.32(n)
    45.13(a)
      797545  XM_001337978.4  XP_001338014.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta futsch1 , 3 axonogenesis microtubule binding3
    CG34387-PC1
    37(a)3
    38.43(n)1
    24.75(a)1
      2A33
    57405441  NM_001103394.31  NP_001096864.11 
    worm
    (Caenorhabditis elegans)
    Secernentea H11E01.36
    Y6B3B.16
    (see all 3)
    Protein Y6B3B.1
    (see all 3)
    12(a)
    10(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    X(1604906-1619150)
    I(13692929-13702954)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YFR016C6
    Putative protein of unknown function; green fluore...
    12(a)
    1 → many
    VI(177042-180743)


    ENSEMBL Gene Tree for MAP1A (if available)
    TreeFam Gene Tree for MAP1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP1A gene
    MAP1B2  MAP1S2  
    3 SIMAP similar genes for MAP1A using alignment to 5 protein entries:     MAP1A_HUMAN (see all proteins):
    M1LP    MAP1B    MAP1S

    MAP1A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/520 SNPs in MAP1A are shown (see all 520)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2010964541,2
    --43807817(+) GAAGC-/TTTTTT 1 -- us2k10--------
    rs1807019451,2
    --43808111(+) GTGAAA/GGCTGA 1 -- us2k10--------
    rs1851331391,2
    --43808174(+) TGGCAA/GCTGAG 1 -- us2k10--------
    rs169578121,2
    F,H--43808276(+) AGCCCT/AAGAAA 1 -- us2k17Minor allele frequency- A:0.23NA NS EA 544
    rs1453272151,2
    --43808324(+) AAGAAC/TGATGA 1 -- us2k10--------
    rs2018437351,2
    --43808388(+) TTCCC-/TGTGTA 1 -- us2k10--------
    rs1907774841,2
    --43808422(+) CCAAAC/TGGGGT 1 -- us2k10--------
    rs1127062361,2
    F--43808449(+) GATTTG/TCATCC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs772418611,2
    F--43808456(+) ATCCCC/TGGATC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1511495901,2
    C--43808457(+) TCCCCA/GGATCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAP1A (43803156 - 43823818 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MAP1A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv428304CNV Loss18775914
    nsv832988CNV Loss17160897
    nsv518707CNV Loss19592680
    nsv515877CNV Loss19592680
    nsv437799CNV Loss16327808
    dgv742e1CNV Complex17122850
    dgv741e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600178    OMIM disorders: --

    10 diseases for MAP1A:    About MalaCards
    transient cerebral ischemia    paraplegia    spasticity    bipolar disorder
    ischemia    cerebritis    schizophrenia    neuroblastoma
    colon cancer    neuronitis


    MAP1A for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for MAP1A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma embryonal 40.9 3 8714690 (2), 8542401 (1)

    Genetic Association Database (GAD): MAP1A
    Human Genome Epidemiology (HuGE) Navigator: MAP1A (2 documents)

    Export disorders for MAP1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP1A gene, integrated from 9 sources (see all 92):
    (articles sorted by number of sources associating them with MAP1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Brain-specific expression of human microtubule-associated protein 1A (MAP1A) gene and its assignment to human chromosome 15. (PubMed id 7629894)1, 2, 3, 9 Fukuyama R. and Rapoport S.I. (1995)
    2. Human microtubule-associated protein 1a (MAP1A) gene: genomic organization, cDNA sequence, and developmental- and tissue-specific expression. (PubMed id 8812494)1, 2, 9 Fink J.K.... Wilkowski J. (1996)
    3. Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15. (PubMed id 7806212)1, 3, 9 Lien L.L.... Kunkel L.M. (1994)
    4. Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses. (PubMed id 19251251)1, 4 Tomppo L....Peltonen L. (2009)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    7. Microtubule-associated protein 1A (MAP1A) and MAP1B: light chains determine distinct functional properties. (PubMed id 11896150)1, 9 Noiges R....Propst F. (2002)
    8. Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter. (PubMed id 12411430)1, 9 Nakayama A.... Takahashi M. (2003)
    9. Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation. (PubMed id 11278895)1, 9 Bonnet C....Larcher J.C. (2001)
    10. Direct interaction between BKCa potassium channel and microtubule-associated protein 1A. (PubMed id 15251455)1, 9 Park S.M....Marx S.O. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4130 HGNC: 6835 AceView: MAP1A Ensembl:ENSG00000166963 euGenes: HUgn4130
    ECgene: MAP1A H-InvDB: MAP1A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAP1A gene:
    Search GeneIP for patents involving MAP1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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