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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAP1A Gene

protein-coding   GIFtS: 56
GCID: GC15P043803

microtubule-associated protein 1A


(Previous symbol: MAP1L)
 Explore 16 diseases affiliated with
MAP1A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAP1A    

Aliases
for MAP1A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Microtubule-Associated Protein 1A1 2     MTAP1A2
MAP1L1 2 3 5     EC 2.7.2.88
Proliferation-Related Protein P802 3     EC 6.3.4.58
MAP-1A2 3     

External Ids:    HGNC: 68351   Entrez Gene: 41302   Ensembl: ENSG000001669637   OMIM: 6001785   UniProtKB: P785593   

Export aliases for MAP1A gene to outside databases

Previous GC identifers: GC15P039180 GC15P036705 GC15P041382 GC15P041528 GC15P041525 GC15P041597 GC15P020657


Summaries
for MAP1A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAP1A:
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are
thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene
is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain
and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat
microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MAP1A_HUMAN, P78559
Function: Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal
elements

Gene Wiki entry for MAP1A


Genomic Views
for MAP1A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAP1A gene promoter:
         AREB6   LHX3b/Lhx3b   GATA-3   MAZR   NRSF form 1   ATF-2   LHX3a/Lhx3a   c-Jun   NRSF form 2   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MAP1A promoter sequence
   Search SABiosciences Chromatin IP Primers for MAP1A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAP1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.3   Ensembl cytogenetic band:  15q15.3   HGNC cytogenetic band: 15q15.3

MAP1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAP1A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P043803:  view genomic region     (about GC identifiers)

Start:
 43,803,156 bp from pter      End:
 43,823,818 bp from pter
Size:
 20,663 bases      Orientation:
 plus strand

Proteins
for MAP1A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MAP1A_HUMAN, P78559 (See protein sequence)
Recommended Name: Microtubule-associated protein 1A  
Size: 2803 amino acids; 305485 Da
Subunit: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with TIAM2.
Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG4. Binds to CSNK1D (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (Probable)
Secondary accessions: O95643 Q12973 Q15882 Q9UJT4
Alternative splicing: 2 isoforms:  P78559-1   P78559-2   (Ref.1 (AAB41132/AAB41133) sequences are in conflict in positions: 2753:S->V, 2754:V->K)

Explore the universe of human proteins at neXtProt for MAP1A: NX_P78559

Post-translational modifications:

  • Phosphorylated by CSNK1D (By similarity)1
  • LC2 is generated from MAP1A by proteolytic processing1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P78559

    • 2 DME Specific Peptides for MAP1A (P78559)
     GVGRLDM  PVISSVA 

    MAP1A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002364.5  
    ENSEMBL proteins: 
     ENSP00000371462   ENSP00000300231   ENSP00000382380  

    Human Recombinant Protein Products: 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MAP1A

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol IEA--
    GO:0005874microtubule IEA--
    GO:0005875microtubule associated complex IEA--


    MAP1A for ontologies           About GeneDecksing



    MAP1A Antibody Products: 
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    Uscn Antibodies for MAP1A
    Search ThermoFisher Antibodies for MAP1A

    Assay Products for MAP1A: 
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    Uscn ELISAs and CLIAs for MAP1A

    Protein Domains /
    Families
    for MAP1A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAP1A for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026074 MAP1

    Graphical View of Domain Structure for InterPro Entry P78559

    ProtoNet protein and cluster: P78559

    UniProtKB/Swiss-Prot: MAP1A_HUMAN, P78559
    Domain: The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules
    Similarity: Belongs to the MAP1 family


    Function
    for MAP1A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MAP1A_HUMAN, P78559
    Function: Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal
    elements

         Genatlas biochemistry entry for MAP1A:
    microtubule associated protein 1A,306kDa

    Enzyme Numbers (IUBMB): EC 6.3.4.52 EC 2.7.2.82

    miRNA
    Products:            		miRTarBase miRNAs that target MAP1A:
    hsa-mir-338-3p (MIRT003040)

    OriGene 3'-UTR Clone: MAP1A
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP1A
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP1A (see all 59):
    hsa-miR-3678-3p hsa-miR-330-5p hsa-miR-15a hsa-miR-449a hsa-miR-1273d hsa-miR-424 hsa-miR-1276 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: MAP1A 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP1A (see all 7)
    OriGene shRNA RFP: MAP1A
    OriGene siRNA: MAP1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP1A

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAP1A

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAP1A (see all 4)
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    GenScript: all cDNA clones in your preferred vector: MAP1A (NM_002373)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAP1A
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAP1A 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MAP1A
    Search LifeMap BioReagents cell lines for MAP1A

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP1A

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity NAS8812494
    GO:0005515protein binding IPI12812986


    MAP1A for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Map1a):
     hearing/vestibular/ear 

    MAP1A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAP1A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAP1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for MAP1A (P785591, 2, 3 ENSP000003002314) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DISC1Q9NRI51, 3, ENSP000003555964EBI-929047,EBI-529989 I2D: score=4 STRING: ENSP00000355596
    DLG4P783523, ENSP000002938134I2D: score=4 STRING: ENSP00000293813
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=3 STRING: ENSP00000363970
    ARHGEF11O150853, ENSP000003571774I2D: score=2 STRING: ENSP00000357177
    DLG1Q129593, ENSP000003457314I2D: score=2 STRING: ENSP00000345731
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007605sensory perception of sound IEA--


    MAP1A for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAP1A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAP1A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAP1A

    1 DrugBank Compound for MAP1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    EstramustineEstramustin Sodium Phosphate (see all 4)2998-57-4targetantagonist1647395

    1 Novoseek chemical compound relationship for MAP1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 1 16234245 (1)

    Search CenterWatch for drugs/clinical trials and news about MAP1A 

    Transcripts
    for MAP1A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAP1A gene: 
    NM_002373.5  

    Unigene Cluster for MAP1A:

    Microtubule-associated protein 1A
    Hs.194301  [show with all ESTs]
    Unigene Representative Sequence: NM_002373
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382031 ENST00000300231 ENST00000399453(uc001zrt.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MAP1A
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAP1A
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate MAP1A (see all 59):
    hsa-miR-3678-3p hsa-miR-330-5p hsa-miR-15a hsa-miR-449a hsa-miR-1273d hsa-miR-424 hsa-miR-1276 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: MAP1A 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAP1A (see all 7)
    OriGene shRNA RFP: MAP1A
    OriGene siRNA: MAP1A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAP1A
    Clone
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    GenScript: all cDNA clones in your preferred vector: MAP1A (NM_002373)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MAP1A 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAP1A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAP1A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAP1A

    Additional cDNA sequence: 

    AF095910.1 AF200415.2 AK291052.1 BC010470.1 BC055312.1 BC094702.1 BC104426.1 BC104427.1 
    U14577.1 U38292.1 U80458.1 

    8 DOTS entries:

    DT.97819905  DT.97800085  DT.453939  DT.92055239  DT.95278232  DT.121036320  DT.91877406  DT.92055638 

    24/179 AceView cDNA sequences (see all 179):

    CA390989 BM930935 T33697 CA432109 BF059045 AL118989 BP361589 CA431563 
    BQ636712 AL533374 AI682285 BX645642 BP349474 AW138764 BM720381 NM_002373 
    BX418029 AI124707 CA393760 AW889891 CA432822 AF200415 BC010470 CA420451 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MAP1A    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8
    SP1:                                                        -                                             
    SP2:                                                                                                      
    SP3:                                      -     -           -                                             
    SP4:                                                                                                      
    SP5:                          -     -     -     -     -     -     -     -     -                           


    ECgene alternative splicing isoforms for MAP1A

    Expression
    for MAP1A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAP1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGGCTTGCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAP1A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeVisceral White AdiposeVisceral White AdipocytesAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MAP1A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAP1A

    SOURCE GeneReport for Unigene cluster: Hs.194301

    UniProtKB/Swiss-Prot: MAP1A_HUMAN, P78559
    Tissue specificity: Brain

        SABiosciences Custom PCR Arrays for MAP1A
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAP1A

    Orthologs
    for MAP1A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MAP1A gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAP1A1 microtubule-associated protein 1A 57.21(n)
    53.44(a)    		   415588  XM_003641838.1  XP_003641886.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MAP1A6
    		 --
    		 37(a)
    		 1 ↔ 1
    		 AAWZ02036659(6892-22695)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC7975451 uncharacterized LOC797545 51.32(n)
    45.13(a)    		   797545  XM_001337978.4  XP_001338014.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta futsch1 , 3 axonogenesis microtubule binding3
    CG34387-PC1    		 37(a)3
    38.43(n)1
    24.75(a)1    		   2A33
    57405441  NM_001103394.31  NP_001096864.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea F25D7.46
    F32A7.56
    (see all 3)    		 Protein F32A7.5, isoform a
    (see all 3)    		 18(a)
    18(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 I(10418225-10421851)
    I(14846467-14850315)


    ENSEMBL Gene Tree for MAP1A (if available)
    TreeFam Gene Tree for MAP1A (if available) 

    Paralogs
    for MAP1A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAP1A gene
    MAP1B2  AKAP122  MAP1S2  
    3 SIMAP similar genes for MAP1A using alignment to 5 protein entries:     MAP1A_HUMAN (see all proteins):
    M1LP    MAP1B    MAP1S

    MAP1A for paralogs           About GeneDecksing



    Genomic Variants
    for MAP1A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/328 NCBI SNPs in MAP1A are shown (see all 328)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2010964541,2
    		--43807817(+) GAAGC-/TTTTTT 1 -- us2k10--------
    rs1807019451,2
    		--43808111(+) GTGAAA/GGCTGA 1 -- us2k10--------
    rs1851331391,2
    		--43808174(+) TGGCAA/GCTGAG 1 -- us2k10--------
    rs169578121,2
    		F,H--43808276(+) AGCCCT/AAGAAA 1 -- us2k17Minor allele frequency- A:0.23NA NS EA 544
    rs1453272151,2
    		--43808324(+) AAGAAC/TGATGA 1 -- us2k10--------
    rs2018437351,2
    		--43808388(+) TTCCC-/TGTGTA 1 -- us2k10--------
    rs1907774841,2
    		--43808422(+) CCAAAC/TGGGGT 1 -- us2k10--------
    rs1127062361,2
    		--43808449(+) GATTTG/TCATCC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs772418611,2
    		--43808456(+) ATCCCC/TGGATC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1511495901,2
    		--43808457(+) TCCCCA/GGATCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAP1A (43803156 - 43823818 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MAP1A
         1 CNV: 3960

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    Disorders / Diseases
    for MAP1A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAP1A for disorders           About GeneDecksing

    OMIM gene information: 600178    OMIM disorders: --

    16 diseases for MAP1A:    About MalaCards
    transient cerebral ischemia    corpus callosum    spastic paraplegia    paraplegia
    spasticity    bipolar disorder    embryonal carcinoma    ischemia
    cerebritis    seizures    colon cancer    carcinoma
    neuroblastoma    schizophrenia    malaria    neuronitis

    1 Novoseek disease relationship for MAP1A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma embryonal 40.9 3 8714690 (2), 8542401 (1)

    Human Genome Epidemiology (HuGE) Navigator: MAP1A (2 documents)

    Export disorders for MAP1A gene to outside databases

    Publications
    for MAP1A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAP1A gene, integrated from 9 sources (see all 87):
    (articles sorted by number of sources associating them with MAP1A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Brain-specific expression of human microtubule-associated protein 1A (MAP1A) gene and its assignment to human chromosome 15. (PubMed id 7629894)1, 2, 3, 9 Fukuyama R. and Rapoport S.I. (1995)
    2. Human microtubule-associated protein 1a (MAP1A) gene: genomic organization, cDNA sequence, and developmental- and tissue-specific expression. (PubMed id 8812494)1, 2, 9 Fink J.K.... Wilkowski J. (1996)
    3. Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15. (PubMed id 7806212)1, 3, 9 Lien L.L.... Kunkel L.M. (1994)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    6. Microtubule-associated protein 1A (MAP1A) and MAP1B: light chains determine distinct functional properties. (PubMed id 11896150)1, 9 Noiges R....Propst F. (2002)
    7. Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter. (PubMed id 12411430)1, 9 Nakayama A.... Takahashi M. (2003)
    8. Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation. (PubMed id 11278895)1, 9 Bonnet C....Larcher J.C. (2001)
    9. Direct interaction between BKCa potassium channel and microtubule-associated protein 1A. (PubMed id 15251455)1, 9 Park S.M....Marx S.O. (2004)
    10. MAP1A light chain 2 interacts with exchange protein activated by cyclic AMP 1 (EPAC1) to enhance Rap1 GTPase activity and cell adhesion. (PubMed id 15591041)1, 9 Gupta M. and Yarwood S.J. (2005)

    External Searches for MAP1A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAP1A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4130 HGNC: 6835 AceView: MAP1A Ensembl:ENSG00000166963 euGenes: HUgn4130
    ECgene: MAP1A H-InvDB: MAP1A

    Other Databases showing MAP1A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAP1A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAP1A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MAP1A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAP1A gene:
    Search GeneIP for patents involving MAP1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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