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Aliases for MAP1A Gene

Aliases for MAP1A Gene

  • Microtubule-Associated Protein 1A 2 3
  • MAP1L 3 4 6
  • Proliferation-Related Protein P80 3 4
  • MAP-1A 3 4
  • EC 2.7.2.8 64
  • EC 6.3.4.5 64
  • MTAP1A 3

External Ids for MAP1A Gene

Previous Symbols for MAP1A Gene

  • MAP1L

Summaries for MAP1A Gene

Entrez Gene Summary for MAP1A Gene

  • This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP1A Gene

MAP1A (Microtubule-Associated Protein 1A) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity and hydrolase activity. An important paralog of this gene is MAP1S.

UniProtKB/Swiss-Prot for MAP1A Gene

  • Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements

Gene Wiki entry for MAP1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP1A Gene

Genomics for MAP1A Gene

Genomic Location for MAP1A Gene

Start:
43,510,958 bp from pter
End:
43,531,620 bp from pter
Size:
20,663 bases
Orientation:
Plus strand

Genomic View for MAP1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP1A Gene

Regulatory Elements for MAP1A Gene

Proteins for MAP1A Gene

  • Protein details for MAP1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78559-MAP1A_HUMAN
    Recommended name:
    Microtubule-associated protein 1A
    Protein Accession:
    P78559
    Secondary Accessions:
    • O95643
    • Q12973
    • Q15882
    • Q9UJT4

    Protein attributes for MAP1A Gene

    Size:
    2803 amino acids
    Molecular mass:
    305485 Da
    Quaternary structure:
    • 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with TIAM2. Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG4. Binds to CSNK1D (By similarity).

    Alternative splice isoforms for MAP1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAP1A Gene

Proteomics data for MAP1A Gene at MOPED

Selected DME Specific Peptides for MAP1A Gene

Post-translational modifications for MAP1A Gene

Other Protein References for MAP1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for MAP1A Gene

Protein Domains for MAP1A Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MAP1A_HUMAN
Domain:
  • The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules:
    • P78559
Family:
  • Belongs to the MAP1 family.:
    • P78559
genes like me logo Genes that share domains with MAP1A: view

No data available for Gene Families for MAP1A Gene

Function for MAP1A Gene

Molecular function for MAP1A Gene

GENATLAS Biochemistry: microtubule associated protein 1A,306kDa
UniProtKB/Swiss-Prot Function: Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements

Enzyme Numbers (IUBMB) for MAP1A Gene

Gene Ontology (GO) - Molecular Function for MAP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity NAS 8812494
GO:0005515 protein binding IPI 12812986
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with MAP1A: view

Phenotypes for MAP1A Gene

genes like me logo Genes that share phenotypes with MAP1A: view

miRNA for MAP1A Gene

miRTarBase miRNAs that target MAP1A

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MAP1A Gene

Localization for MAP1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP1A Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAP1A Gene COMPARTMENTS Subcellular localization image for MAP1A gene
Compartment Confidence
cytoskeleton 4
nucleus 3
cytosol 2
vacuole 2
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MAP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0005874 microtubule IEA --
GO:0005875 microtubule associated complex TAS 8812494
genes like me logo Genes that share ontologies with MAP1A: view

Pathways for MAP1A Gene

SuperPathways for MAP1A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MAP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0007605 sensory perception of sound IEA --
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with MAP1A: view

No data available for Pathways by source for MAP1A Gene

Compounds for MAP1A Gene

(1) Drugbank Compounds for MAP1A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Estramustine
  • Estramustin Sodium Phosphate
2998-57-4 target antagonist

(1) Novoseek inferred chemical compound relationships for MAP1A Gene

Compound -log(P) Hits PubMed IDs
calcium 0 1
genes like me logo Genes that share compounds with MAP1A: view

Transcripts for MAP1A Gene

mRNA/cDNA for MAP1A Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(179) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAP1A Gene

Microtubule-associated protein 1A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP1A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8
SP1: -
SP2:
SP3: - - -
SP4:
SP5: - - - - - - - - -

Relevant External Links for MAP1A Gene

GeneLoc Exon Structure for
MAP1A
ECgene alternative splicing isoforms for
MAP1A

Expression for MAP1A Gene

mRNA expression in normal human tissues for MAP1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP1A Gene

This gene is overexpressed in Brain - Cortex (5.8), Brain - Frontal Cortex (BA9) (5.7), Brain - Anterior cingulate cortex (BA24) (5.4), Brain - Amygdala (4.3), and Brain - Hippocampus (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP1A Gene

SOURCE GeneReport for Unigene cluster for MAP1A Gene Hs.194301

mRNA Expression by UniProt/SwissProt for MAP1A Gene

P78559-MAP1A_HUMAN
Tissue specificity: Brain
genes like me logo Genes that share expressions with MAP1A: view

Orthologs for MAP1A Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAP1A 36
  • 99.58 (n)
  • 99.36 (a)
MAP1A 37
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAP1A 36
  • 85.7 (n)
  • 84.8 (a)
MAP1A 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP1A 36
  • 88.31 (n)
  • 86.29 (a)
MAP1A 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Map1a 36
  • 83.1 (n)
  • 81.76 (a)
Map1a 16
Map1a 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAP1A 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map1a 36
  • 82.42 (n)
  • 81.24 (a)
chicken
(Gallus gallus)
Aves MAP1A 36
  • 59.76 (n)
  • 58.29 (a)
MAP1A 37
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAP1A 37
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii map1aa 37
  • 56 (a)
OneToMany
map1ab 37
  • 26 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta dp 37
  • 3 (a)
ManyToMany
futsch 37
  • 12 (a)
ManyToMany
futsch 38
  • 37 (a)
Species with no ortholog for MAP1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP1A Gene

ENSEMBL:
Gene Tree for MAP1A (if available)
TreeFam:
Gene Tree for MAP1A (if available)

Paralogs for MAP1A Gene

Paralogs for MAP1A Gene

Selected SIMAP similar genes for MAP1A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MAP1A: view

Variants for MAP1A Gene

Sequence variations from dbSNP and Humsavar for MAP1A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs480108 -- 43,525,208(+) GAGGA(C/T)ACCTC synonymous-codon, reference
rs523156 -- 43,519,645(+) TGTCT(C/G)ATTTG intron-variant
rs529611 -- 43,513,790(+) ATCCC(C/T)AATGA intron-variant
rs559805 -- 43,514,790(+) CGAGC(A/G)TTCTA intron-variant
rs570933 -- 43,531,832(-) CCCCT(C/T)CCCAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MAP1A Gene

Variant ID Type Subtype PubMed ID
nsv437799 CNV Loss 16327808
nsv515877 CNV Loss 19592680
nsv518707 CNV Loss 19592680
nsv832988 CNV Loss 17160897
nsv428304 CNV Loss 18775914
dgv741e1 CNV Complex 17122850
dgv742e1 CNV Complex 17122850

Relevant External Links for MAP1A Gene

HapMap Linkage Disequilibrium report
MAP1A
Human Gene Mutation Database (HGMD)
MAP1A

Disorders for MAP1A Gene

(1) Novoseek inferred disease relationships for MAP1A Gene

Disease -log(P) Hits PubMed IDs
carcinoma embryonal 40.9 3

Relevant External Links for MAP1A

Genetic Association Database (GAD)
MAP1A
Human Genome Epidemiology (HuGE) Navigator
MAP1A
genes like me logo Genes that share disorders with MAP1A: view

No data available for UniProtKB/Swiss-Prot for MAP1A Gene

Publications for MAP1A Gene

  1. Brain-specific expression of human microtubule-associated protein 1A (MAP1A) gene and its assignment to human chromosome 15. (PMID: 7629894) Fukuyama R. … Rapoport S.I. (J. Neurosci. Res. 1995) 2 3 4 23
  2. Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15. (PMID: 7806212) Lien L.L. … Kunkel L.M. (Genomics 1994) 2 3 23
  3. Human microtubule-associated protein 1a (MAP1A) gene: genomic organization, cDNA sequence, and developmental- and tissue-specific expression. (PMID: 8812494) Fink J.K. … Wilkowski J. (Genomics 1996) 3 4 23
  4. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. (PMID: 9786987) Brenman J.E. … Bredt D.S. (J. Neurosci. 1998) 3 23
  5. Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation. (PMID: 11278895) Bonnet C. … Larcher J.C. (J. Biol. Chem. 2001) 3 23

Products for MAP1A Gene

Sources for MAP1A Gene

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