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Aliases for MAP10 Gene

Aliases for MAP10 Gene

  • Microtubule Associated Protein 10 2 3 5
  • KIAA1383 2 3 4
  • Microtubule Regulator Of 120 KDa 3 4
  • Microtubule Regulator 120 KDa 2 3
  • MTR120 3 4

External Ids for MAP10 Gene

Previous HGNC Symbols for MAP10 Gene

  • KIAA1383

Previous GeneCards Identifiers for MAP10 Gene

  • GC01P232941

Summaries for MAP10 Gene

GeneCards Summary for MAP10 Gene

MAP10 (Microtubule Associated Protein 10) is a Protein Coding gene. GO annotations related to this gene include microtubule binding.

UniProtKB/Swiss-Prot for MAP10 Gene

  • Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP10 Gene

Genomics for MAP10 Gene

Regulatory Elements for MAP10 Gene

Promoters for MAP10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAP10 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAP10 Gene

Chromosome:
1
Start:
232,804,892 bp from pter
End:
232,810,346 bp from pter
Size:
5,455 bases
Orientation:
Plus strand

Genomic View for MAP10 Gene

Genes around MAP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP10 Gene

Proteins for MAP10 Gene

  • Protein details for MAP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2G4-MAP10_HUMAN
    Recommended name:
    Microtubule-associated protein 10
    Protein Accession:
    Q9P2G4
    Secondary Accessions:
    • A8K2F1
    • Q32MI1
    • Q58EZ9
    • Q5VV83

    Protein attributes for MAP10 Gene

    Size:
    905 amino acids
    Molecular mass:
    100345 Da
    Quaternary structure:
    • Interacts (via middle region) with microtubules.
    SequenceCaution:
    • Sequence=BAA92621.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH72001.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for MAP10 Gene

Proteomics data for MAP10 Gene at MOPED

Post-translational modifications for MAP10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MAP10 Gene

Domains & Families for MAP10 Gene

Protein Domains for MAP10 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MAP10: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MAP10 Gene

Function for MAP10 Gene

Molecular function for MAP10 Gene

UniProtKB/Swiss-Prot Function:
Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis.

Phenotypes for MAP10 Gene

GenomeRNAi human phenotypes for MAP10:
genes like me logo Genes that share phenotypes with MAP10: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAP10 Gene

Localization for MAP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAP10 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Localized at stabilized microtubules (MTs) during interphase and to the mitotic apparatus during mitosis. Localized at spindle poles in metaphase and spindle midzone during telophase. Colocalized with Polo-like kinase PLK1 to the center of spindle midzone. Localized at the midbody during cytokinesis. Colocalized with acetylated-tubulin at MTs.

Gene Ontology (GO) - Cellular Components for MAP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1990023 mitotic spindle midzone IDA 23264731
genes like me logo Genes that share ontologies with MAP10: view

No data available for Subcellular locations from COMPARTMENTS for MAP10 Gene

Pathways & Interactions for MAP10 Gene

SuperPathways for MAP10 Gene

No Data Available

Interacting Proteins for MAP10 Gene

Gene Ontology (GO) - Biological Process for MAP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031122 cytoplasmic microtubule organization IMP 23264731
genes like me logo Genes that share ontologies with MAP10: view

No data available for Pathways by source and SIGNOR curated interactions for MAP10 Gene

Drugs & Compounds for MAP10 Gene

(16) Drugs for MAP10 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cabazitaxel Approved Pharma 0
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1844
Griseofulvin Approved Pharma 6
Vincristine Approved, Investigational Pharma Microtubule disrupter,antitumor agent 863
Nocodazole Experimental Pharma Tubulin production inhibitor,anti-neoplastic agent, Microtubule inhibitor 0

(16) ApexBio Compounds for MAP10 Gene

Compound Action Cas Number
2-Methoxyestradiol (2-MeOE2) Apoptotic, antiproliferative and antiangiogenic agent 362-07-2
Cabazitaxel 183133-96-2
CK-636 Arp2/3 complex inhibitor 442632-72-6
CYT997 (Lexibulin) 917111-44-5
Docetaxel Microtubulin disassembly inhibitor 114977-28-5
Epothilone A Microtubule stabilizing macrolide 152044-53-6
Epothilone B (EPO906, Patupilone) Microtubule stabilizing macrolide 152044-54-7
Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium 168555-66-6
Griseofulvin 126-07-8
INH6 1001753-24-7
MPC 6827 hydrochloride Potent microtubule inhibitor 917369-31-4
Nocodazole Tubulin production inhibitor,anti-neoplastic agent 31430-18-9
Plinabulin (NPI-2358) Tumor cell lines inhibitor 714272-27-2
Vincristine Microtubule disrupter,antitumor agent 2068-78-2
Vinflunine Tartrate 1201898-17-0
Vinorelbine ditartrate Anti-mitotic chemotherapy drug 125317-39-7
genes like me logo Genes that share compounds with MAP10: view

Transcripts for MAP10 Gene

mRNA/cDNA for MAP10 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAP10 Gene

Microtubule-associated protein 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP10 Gene

No ASD Table

Relevant External Links for MAP10 Gene

GeneLoc Exon Structure for
MAP10
ECgene alternative splicing isoforms for
MAP10

Expression for MAP10 Gene

mRNA expression in normal human tissues for MAP10 Gene

Protein differential expression in normal tissues from HIPED for MAP10 Gene

This gene is overexpressed in Urine (57.4) and Platelet (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAP10 Gene



SOURCE GeneReport for Unigene cluster for MAP10 Gene Hs.160373

mRNA Expression by UniProt/SwissProt for MAP10 Gene

Q9P2G4-MAP10_HUMAN
Tissue specificity: Expressed in different cell lines (at protein level).
genes like me logo Genes that share expression patterns with MAP10: view

Protein tissue co-expression partners for MAP10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MAP10 Gene

Orthologs for MAP10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAP10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAP10 35
  • 79.87 (n)
  • 68.57 (a)
MAP10 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAP10 35
  • 79.98 (n)
  • 68.74 (a)
mouse
(Mus musculus)
Mammalia Map10 35
  • 67.11 (n)
  • 54.92 (a)
Map10 16
Map10 36
  • 50 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIAA1383 35
  • 99.43 (n)
  • 98.66 (a)
MAP10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Map10 35
  • 65.98 (n)
  • 55.35 (a)
oppossum
(Monodelphis domestica)
Mammalia MAP10 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAP10 35
  • 48.64 (n)
  • 36.56 (a)
-- 36
  • 32 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MAP10 36
  • 32 (a)
OneToOne
Species with no ortholog for MAP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MAP10 Gene

ENSEMBL:
Gene Tree for MAP10 (if available)
TreeFam:
Gene Tree for MAP10 (if available)

Paralogs for MAP10 Gene

No data available for Paralogs for MAP10 Gene

Variants for MAP10 Gene

Sequence variations from dbSNP and Humsavar for MAP10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1845789 -- 232,808,823(+) TGTAT(C/T)TAGCA utr-variant-3-prime
rs2029863 -- 232,803,417(-) gagat(C/T)gcacc upstream-variant-2KB
rs2814526 -- 232,805,644(+) TTCCC(C/G)ACGCT reference, synonymous-codon
rs2795462 -- 232,809,180(-) AATTA(A/T)AAATT utr-variant-3-prime
rs3766497 -- 232,805,931(-) GGAAA(A/C)GTCCC reference, missense

Variation tolerance for MAP10 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.29; 85.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAP10 Gene

HapMap Linkage Disequilibrium report
MAP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAP10 Gene

Disorders for MAP10 Gene

Relevant External Links for MAP10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAP10

No disorders were found for MAP10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP10 Gene

Publications for MAP10 Gene

  1. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. (PMID: 23264731) Fong K.W. … Chen J. (J. Cell Sci. 2013) 2 3 4 67
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MAP10 Gene

Sources for MAP10 Gene

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