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Aliases for MAOB Gene

Aliases for MAOB Gene

  • Monoamine Oxidase B 2 3 5
  • Monoamine Oxidase Type B 3 4
  • EC 1.4.3.4 4 58
  • MAO-B 3 4
  • Amine Oxidase [Flavin-Containing] B 3
  • Adrenalin Oxidase 3
  • Tyramine Oxidase 3
  • MAO, Platelet 3
  • MAO, Brain 3
  • EC 1.4.3 58

External Ids for MAOB Gene

Previous GeneCards Identifiers for MAOB Gene

  • GC0XM041637
  • GC0XM041886
  • GC0XM042452
  • GC0XM042671
  • GC0XM043383
  • GC0XM043510
  • GC0XM043625
  • GC0XM041355

Summaries for MAOB Gene

Entrez Gene Summary for MAOB Gene

  • The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAOB Gene

MAOB (Monoamine Oxidase B) is a Protein Coding gene. Diseases associated with MAOB include Norrie Disease and Postencephalitic Parkinson Disease. Among its related pathways are Dopamine metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and electron carrier activity. An important paralog of this gene is MAOA.

UniProtKB/Swiss-Prot for MAOB Gene

  • Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

Tocris Summary for MAOB Gene

  • Monoamine Oxidases (MAO) catalyze the oxidation of monoamines such as dopamine, serotonin and adrenalin. They are found bound to the outer membrane of mitochondria in most cell types in the body. Two subtypes of MAO have been identified: MAO-A and MAO-B.

Gene Wiki entry for MAOB Gene

Additional gene information for MAOB Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAOB Gene

Genomics for MAOB Gene

Regulatory Elements for MAOB Gene

Enhancers for MAOB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH044313 1.5 FANTOM5 Ensembl ENCODE 6.5 -432.3 -432256 3 PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 ATF7 NCOA1 REST EFHC2 MAOB RRM2P3
GH0XH043860 0.6 ENCODE 13.9 +21.0 20953 2 ELF3 SOX13 RFX1 NFIA HLF RAD21 JUND ATF3 HNF4A TRIM28 MAOB GC0XM043837
GH0XH042939 1.4 FANTOM5 Ensembl ENCODE dbSUPER 5 +937.6 937621 9 POLR2A CBFB JUN DPF2 RUNX3 IKZF2 MAOB LOC105373188 ENSG00000270280
GH0XH043877 0.9 ENCODE 0.7 +1.9 1885 5 TBP THRB RAD21 RARA EGR1 SCRT2 CREM HMG20B SP5 CEBPB MAOB GC0XM043837
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAOB on UCSC Golden Path with GeneCards custom track

Promoters for MAOB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000246137 75 401 BRD4 SOX13 SAP130 RARA ZFHX2 POLR2A EGR1 SCRT2 NR2F6 TCF7L2

Genomic Location for MAOB Gene

Chromosome:
X
Start:
43,766,610 bp from pter
End:
43,882,475 bp from pter
Size:
115,866 bases
Orientation:
Minus strand

Genomic View for MAOB Gene

Genes around MAOB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAOB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAOB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAOB Gene

Proteins for MAOB Gene

  • Protein details for MAOB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27338-AOFB_HUMAN
    Recommended name:
    Amine oxidase [flavin-containing] B
    Protein Accession:
    P27338
    Secondary Accessions:
    • B2R6R3
    • B7Z5H3
    • D3DWC3
    • Q7Z6S2

    Protein attributes for MAOB Gene

    Size:
    520 amino acids
    Molecular mass:
    58763 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer (By similarity).

    Three dimensional structures from OCA and Proteopedia for MAOB Gene

    Alternative splice isoforms for MAOB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAOB Gene

Selected DME Specific Peptides for MAOB Gene

P27338:
  • AGERAARE
  • EPESVDVPA
  • DLGGSYVGPTQN
  • SATALGFLAHK
  • GCYTTYFPPGI
  • RVPLGSVIKCIVYYK
  • RNQKVKY
  • RVGGRTYT
  • GPTQNRILR
  • EIPSDAPWKAPLAEEWD
  • WSGYMEGAV
  • LPSVPGLL
  • YEAKYVISA
  • VSALWFLWYVKQCGGTTRI
  • KELGLETYKVNEVERLIH
  • FPPVWNP
  • FAGTETAT
  • LGDRVKL
  • VLEARDRVGGRT
  • IHHVKGKSYPFRGPFPP
  • LFVNLCVTAE
  • RLTKEERL
  • HEVSALWFLWYV
  • PVHYEEKNWC
  • CELYAKVLGS
  • DDMGREIPSDAPWKAPLAE
  • IWQSEPES
  • VGGRTYTLRNQ
  • YVISAIPP

Post-translational modifications for MAOB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAOB Gene

Domains & Families for MAOB Gene

Gene Families for MAOB Gene

Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

P27338

UniProtKB/Swiss-Prot:

AOFB_HUMAN :
  • Belongs to the flavin monoamine oxidase family.
Family:
  • Belongs to the flavin monoamine oxidase family.
genes like me logo Genes that share domains with MAOB: view

Function for MAOB Gene

Molecular function for MAOB Gene

GENATLAS Biochemistry:
monoamine oxidase B
UniProtKB/Swiss-Prot CatalyticActivity:
RCH(2)NHR + H(2)O + O(2) = RCHO + RNH(2) + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

Enzyme Numbers (IUBMB) for MAOB Gene

Phenotypes From GWAS Catalog for MAOB Gene

Gene Ontology (GO) - Molecular Function for MAOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008131 primary amine oxidase activity TAS,IEA --
GO:0009055 electron carrier activity TAS 8602220
GO:0016491 oxidoreductase activity IEA --
GO:0042803 protein homodimerization activity IEA --
GO:0050660 flavin adenine dinucleotide binding IEA --
genes like me logo Genes that share ontologies with MAOB: view
genes like me logo Genes that share phenotypes with MAOB: view

Animal Models for MAOB Gene

MGI Knock Outs for MAOB:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MAOB
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAOB Gene

Localization for MAOB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAOB Gene

Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAOB gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 3
peroxisome 2
cytosol 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MAOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 20833797
GO:0005740 mitochondrial envelope TAS 7063850
GO:0005741 mitochondrial outer membrane TAS 24252804
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MAOB: view

Pathways & Interactions for MAOB Gene

genes like me logo Genes that share pathways with MAOB: view

Gene Ontology (GO) - Biological Process for MAOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009636 response to toxic substance IEA --
GO:0010044 response to aluminum ion IEA --
GO:0010269 response to selenium ion IEA --
GO:0014063 negative regulation of serotonin secretion IEA --
GO:0021762 substantia nigra development IEP 22926577
genes like me logo Genes that share ontologies with MAOB: view

No data available for SIGNOR curated interactions for MAOB Gene

Drugs & Compounds for MAOB Gene

(123) Drugs for MAOB Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Moclobemide Approved Pharma inhibitor, Enzyme Reversible MAO-A inhibitor 7
Methamphetamine Approved, Illicit Pharma antagonist, Target, inhibitor 258
Phenelzine Approved Pharma inhibitor, Target, Enzyme, antagonist, substrate 7
Rasagiline Approved Pharma inhibitor, Target 54
Selegiline Approved, Investigational, Vet_approved Pharma inhibitor, Target 27

(88) Additional Compounds for MAOB Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Methylhistamine
  • 1-Methyl-1H-imidazole-4-ethanamine
  • 1-Methyl-4-(2-aminoethyl)imidazole
  • 1-Methyl-4-(b-aminoethyl)imidazole
  • 1-Methyl-4-(beta-aminoethyl)imidazole
  • 1-Methyl-4-histamine
501-75-7
1-Phenylethylamine
  • (1-Aminoethyl)benzene
  • (S)-(-)-a-Methyl-benzylamine
  • 1-Amino-1-phenylethane
  • 1-Fenylethylamin
  • 1-Phenyl-1-ethanamine
98-84-0
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
  • 3,4-Dihydroxyphenylglycolic aldehyde
  • a,3,4-Trihydroxy-Benzeneacetaldehyde
  • alpha,3,4-Trihydroxy-Benzeneacetaldehyde
13023-73-9
3,4-Dihydroxyphenylacetaldehyde
  • 3,4-Dihydroxy-Benzeneacetaldehyde
  • Protocatechuatealdehyde
5707-55-1
3-Hydroxykynurenamine

(5) Tocris Compounds for MAOB Gene

Compound Action Cas Number
(R)-(-)-Deprenyl hydrochloride MAO-B inhibitor 14611-52-0
Bifemelane hydrochloride MAO-A and MAO-B inhibitor 62232-46-6
Lazabemide hydrochloride Selective MAO-B inhibitor 103878-83-7
Moclobemide Reversible MAO-A inhibitor 71320-77-9
Rasagiline mesylate Selective, irreversible MAO-B inhibitor 161735-79-1

(14) ApexBio Compounds for MAOB Gene

Compound Action Cas Number
2-BFI hydrochloride
BU 224 hydrochloride Antagonist of I2 Imidazoline receptor,potent and selective 205437-64-5
BU 226 hydrochloride Ligand at I2 imidazoline sites,high affinity and selectivity 1186195-56-1
BU 239 hydrochloride Ligand of imidazoline I2 receptor,potent and selective 1217041-98-9
Paeonol MAO inhibitor;multi-functional phenolic compound 552-41-0
Pirlindole mesylate 207572-66-5
Procarbazine HCl Antineoplastic chemotherapy drug 366-70-1
Rasagiline Mesylate Irreversible MAO-B inhibitor 161735-79-1
RS 45041-190 hydrochloride 204274-74-8
Safinamide Mesylate MAO-B inhibitor,potent,selective and reversible 202825-46-5
Sennoside A Irritant laxative;mild MAO inhibitor 81-27-6
Tetrindole mesylate 170964-68-8
Tranylcypromine (2-PCPA) HCl Monoamine oxidase inhibitor 4548-34-9
Tranylcypromine hydrochloride 1986-47-6
genes like me logo Genes that share compounds with MAOB: view

Drug Products

Transcripts for MAOB Gene

Unigene Clusters for MAOB Gene

Monoamine oxidase B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MAOB
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MAOB Gene

No ASD Table

Relevant External Links for MAOB Gene

GeneLoc Exon Structure for
MAOB
ECgene alternative splicing isoforms for
MAOB

Expression for MAOB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAOB Gene

Protein differential expression in normal tissues from HIPED for MAOB Gene

This gene is overexpressed in Spinal cord (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAOB Gene



Protein tissue co-expression partners for MAOB Gene

NURSA nuclear receptor signaling pathways regulating expression of MAOB Gene:

MAOB

SOURCE GeneReport for Unigene cluster for MAOB Gene:

Hs.654473

Evidence on tissue expression from TISSUES for MAOB Gene

  • Liver(4.7)
  • Nervous system(4.6)
  • Adrenal gland(2.7)
  • Blood(2.7)
  • Kidney(2.7)
  • Heart(2.6)
  • Muscle(2.3)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with MAOB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MAOB Gene

Orthologs for MAOB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAOB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAOB 33 34
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia MAOB 33 34
  • 91.79 (n)
cow
(Bos Taurus)
Mammalia MAOB 33 34
  • 90.64 (n)
oppossum
(Monodelphis domestica)
Mammalia MAOB 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Maob 33 16 34
  • 87.58 (n)
rat
(Rattus norvegicus)
Mammalia Maob 33
  • 86.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAOB 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAOB 33 34
  • 74.57 (n)
lizard
(Anolis carolinensis)
Reptilia MAOB 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494267 33
  • 72.96 (n)
zebrafish
(Danio rerio)
Actinopterygii mao 33 34
  • 68.53 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11797 33
bread mold
(Neurospora crassa)
Ascomycetes NCU05933 33
  • 42.47 (n)
Species where no ortholog for MAOB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAOB Gene

ENSEMBL:
Gene Tree for MAOB (if available)
TreeFam:
Gene Tree for MAOB (if available)

Paralogs for MAOB Gene

Paralogs for MAOB Gene

(1) SIMAP similar genes for MAOB Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MAOB: view

Variants for MAOB Gene

Sequence variations from dbSNP and Humsavar for MAOB Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000040857 -- 43,840,102(+) AACAA(C/T)GGCCA intron-variant
rs1000048335 -- 43,857,291(+) TTCTC(C/T)TGTCT intron-variant
rs1000055494 -- 43,801,967(+) TTTGT(A/G)ATACA intron-variant
rs1000083105 -- 43,824,250(+) CACAT(A/G)TGCTG intron-variant
rs1000143476 -- 43,848,520(+) TTTTA(A/T)GTTGT intron-variant, upstream-variant-2KB

Variation tolerance for MAOB Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAOB Gene

Human Gene Mutation Database (HGMD)
MAOB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAOB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MAOB Gene

Disorders for MAOB Gene

MalaCards: The human disease database

(29) MalaCards diseases for MAOB Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
norrie disease
  • atrophia bulborum hereditaria
postencephalitic parkinson disease
  • postencephalitic parkinsonism
pathological gambling
  • compulsive gambling
dependent personality disorder
antisocial personality disorder
  • asocial personality
- elite association - COSMIC cancer census association via MalaCards
Search MAOB in MalaCards View complete list of genes associated with diseases

Genatlas disease for MAOB Gene

monoamine oxidase deficiency

Relevant External Links for MAOB

Genetic Association Database (GAD)
MAOB
Human Genome Epidemiology (HuGE) Navigator
MAOB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAOB
genes like me logo Genes that share disorders with MAOB: view

No data available for UniProtKB/Swiss-Prot for MAOB Gene

Publications for MAOB Gene

  1. Negative emotionality: monoamine oxidase B gene variants modulate personality traits in healthy humans. (PMID: 19657584) Dlugos AM … de Wit H (Journal of neural transmission (Vienna, Austria : 1996) 2009) 3 22 45 60
  2. A common variant in DRD3 gene is associated with risperidone-induced extrapyramidal symptoms. (PMID: 19506579) Gassó P … Lafuente A (The pharmacogenomics journal 2009) 3 22 45 60
  3. The monoamine oxidase B gene exhibits significant association to ADHD. (PMID: 17918234) Li J … Faraone SV (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 22 45 60
  4. Gene-gene interaction between FGF20 and MAOB in Parkinson disease. (PMID: 18205889) Gao X … Martin ER (Annals of human genetics 2008) 3 22 45 60
  5. Association of A/G polymorphism in intron 13 of the monoamine oxidase B gene with schizophrenia in a Spanish population. (PMID: 18832861) Gassó P … Lafuente A (Neuropsychobiology 2008) 3 22 45 60

Products for MAOB Gene

Sources for MAOB Gene

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