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MAOB Gene

protein-coding   GIFtS: 67
GCID: GC0XM043625

Monoamine Oxidase B

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Monoamine Oxidase B1 2     Amine Oxidase [Flavin-Containing] B2
Monoamine Oxidase Type B2 3     MAO, Brain2
MAO-B2 3     MAO, Platelet2
EC 1.4.3.43 8     Tyramine Oxidase2
Adrenalin Oxidase2     EC 1.4.38

External Ids:    HGNC: 68341   Entrez Gene: 41292   Ensembl: ENSG000000695357   OMIM: 3098605   UniProtKB: P273383   

Export aliases for MAOB gene to outside databases

Previous GC identifers: GC0XM041637 GC0XM041886 GC0XM042452 GC0XM042671 GC0XM043383 GC0XM043510 GC0XM041355


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAOB Gene:
The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the
mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays
an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and
peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. (provided by RefSeq,
Jul 2008)

GeneCards Summary for MAOB Gene:
MAOB (monoamine oxidase B) is a protein-coding gene. Diseases associated with MAOB include deep brain stimulation for parkinson's disease, and norrie disease. GO annotations related to this gene include protein homodimerization activity and flavin adenine dinucleotide binding. An important paralog of this gene is MAOA.

UniProtKB/Swiss-Prot: AOFB_HUMAN, P27338
Function: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the
metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB
preferentially degrades benzylamine and phenylethylamine

summary for MAOB Gene:
Monoamine Oxidases (MAO) catalyze the oxidation of monoamines such as dopamine, serotonin and adrenalin.
They are found bound to the outer membrane of mitochondria in most cell types in the body. Two subtypes of
monoamine oxidase have been identified: MAO-A and MAO-B. Both are found in neurons and astroglia, with MAO-A
also found in the liver, gastrointestinal tract and placenta and MAO-B in blood platelets. Abnormal
regulation of MAOs in the body has been associated with depression, substance abuse, attention deficit
disorder, and irregular sexual maturation.

Gene Wiki entry for MAOB (Monoamine oxidase B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_079573.5  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAOB gene promoter:
         c-Fos   AREB6   Sox5   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAOB promoter sequence
   Search Chromatin IP Primers for MAOB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAOB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.3   HGNC cytogenetic band: Xp11.4-p11.3

MAOB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAOB gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM043625:  view genomic region     (about GC identifiers)

Start:
43,625,857 bp from pter      End:
43,741,721 bp from pter
Size:
115,865 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AOFB_HUMAN, P27338 (See protein sequence)
Recommended Name: Amine oxidase [flavin-containing] B  
Size: 520 amino acids; 58763 Da
Cofactor: FAD
Subunit: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a
covalently bound flavin. Enzymatically active as monomer (By similarity)
Mass spectrometry: Mass=59474; Mass_error=14.0; Method=Electrospray; Range=2-520; Source=PubMed:11049757;
Selected PDB 3D structures from and Proteopedia for MAOB (see all 39):
1GOS (3D)        1H8R (3D)        1OJ9 (3D)        1OJA (3D)        1OJC (3D)        1OJD (3D)    
Secondary accessions: B2R6R3 D3DWC3 Q7Z6S2

Explore the universe of human proteins at neXtProt for MAOB: NX_P27338

Explore proteomics data for MAOB at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAOB (P27338) (see all 29)
     LGDRVKL  FPPVWNP  RNQKVKY  FAGTETAT 


    See MAOB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000889.3  
    ENSEMBL proteins: 
     ENSP00000367309   ENSP00000441613   ENSP00000442240  
    Reactome Protein details: P27338

    MAOB Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for MAOB
    OriGene Custom MassSpec
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    Novus Biologicals MAOB Protein
    Novus Biologicals MAOB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for MAOB
    Cloud-Clone Corp. Proteins for MAOB

    MAOB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAOB
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    LSBio Antibodies in human, mouse, rat for MAOB

    MAOB Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MAOB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAOB
    Cloud-Clone Corp. CLIAs for MAOB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001613 Flavin_amine_oxidase
     IPR002937 Amino_oxidase

    Graphical View of Domain Structure for InterPro Entry P27338

    ProtoNet protein and cluster: P27338

    1 Blocks protein domain: IPB001613 Flavin-containing amine oxidase signature

    UniProtKB/Swiss-Prot: AOFB_HUMAN, P27338
    Similarity: Belongs to the flavin monoamine oxidase family


    MAOB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AOFB_HUMAN, P27338
    Function: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the
    metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB
    preferentially degrades benzylamine and phenylethylamine
    Catalytic activity: RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2)

         Genatlas biochemistry entry for MAOB:
    monoamine oxidase B

         Enzyme Numbers (IUBMB): EC 1.4.3.41 2 EC 1.4.32

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008131primary amine oxidase activity TAS--
    GO:0009055electron carrier activity TAS8602220
    GO:0016491oxidoreductase activity ----
    GO:0042803protein homodimerization activity IEA--
    GO:0050660flavin adenine dinucleotide binding IEA--
         
    MAOB for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Maob):
     behavior/neurological  cellular  homeostasis/metabolism  nervous system  renal/urinary system 

    MAOB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Maobtm1Shih for MAOB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAOB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAOB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAOB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAOB

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MAOB using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MAOB:
    hsa-miR-618
    SwitchGear 3'UTR luciferase reporter plasmidMAOB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAOB
    Predesigned siRNA for gene silencing in human, mouse, rat MAOB

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for MAOB (see all 7)
    OriGene ORF clones in mouse, rat for MAOB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAOB (NM_000898)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAOB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAOB

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAOB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AOFB_HUMAN, P27338: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus2
    peroxisome2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005740mitochondrial envelope TAS7063850
    GO:0005741mitochondrial outer membrane TAS--
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016021integral component of membrane IEA--

    MAOB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAOB About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Phenylalanine metabolism
    Phenylalanine metabolism0.36
    noradrenaline and adrenaline degradation0.31
    Tyrosine metabolism0.36
    phenylalanine degradation IV0.00
    phenylalanine utilization0.33
    2Tryptophan metabolism
    Tryptophan metabolism0.46
    Tryptophan metabolism0.46
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4Cytochrome P450 - arranged by substrate type
    Phase 1 - Functionalization of compounds0.75
    Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O20.00
    Amine Oxidase reactions0.00
    5tryptophan utilization II
    tryptophan utilization I0.71
    tryptophan degradation X (mammalian, via tryptamine)0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for MAOB
        Tyrosine metabolism p.1 (dopamine)

    Selected BioSystems Pathways for MAOB (see all 10)
        dopamine degradation
    noradrenaline and adrenaline degradation
    tryptophan degradation X (mammalian, via tryptamine)
    phenylalanine degradation IV
    putrescine degradation III

    1 Reactome Pathway for MAOB
        Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2


    Selected Kegg Pathways  (Kegg details for MAOB) (see all 13):
        Glycine, serine and threonine metabolism
    Arginine and proline metabolism
    Histidine metabolism
    Tyrosine metabolism
    Phenylalanine metabolism


    MAOB for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAOB: 
              Amino Acid Metabolism I in human mouse rat
              Hepatotoxicity in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAOB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAOB (P273382, 3 ENSP000003673094) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    AANATENSP000002506154STRING: ENSP00000250615
    ADH1AENSP000002096684STRING: ENSP00000209668
    ADH1BENSP000003066064STRING: ENSP00000306606
    ADH6ENSP000003783594STRING: ENSP00000378359
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0009636response to toxic substance IEA--
    GO:0010044response to aluminum ion IEA--
    GO:0010269response to selenium ion IEA--
    GO:0014063negative regulation of serotonin secretion IEA--

    MAOB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MAOB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Rasagiline mesylate Selective, irreversible MAO-B inhibitor [161735-79-1]
    (R)-(-)-Deprenyl hydrochlorideMAO-B inhibitor[14611-52-0]
    MoclobemideReversible MAO-A inhibitor[71320-77-9]
    Lazabemide hydrochlorideSelective MAO-B inhibitor[103878-83-7]
    Bifemelane hydrochlorideMAO-A and MAO-B inhibitor[90293-01-9]

    Selected HMDB Compounds for MAOB (see all 37)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Methylhistamine1-Methyl-1H-imidazole-4-ethanamine (see all 21)501-75-7--
    1-Phenylethylaminea-phenylethylamine (see all 17)98-84-0--
    3,4-Dihydroxymandelaldehyde3,4-Dihydroxyphenylglycolaldehyde (see all 4)13023-73-9--
    3,4-DihydroxyphenylacetaldehydeProtocatechuatealdehyde (see all 2)5707-55-1--
    3-Methoxy-4-hydroxyphenylglycolaldehydea,4-dihydroxy-3-methoxy-Benzeneacetaldehyde (see all 4)17592-23-3--
    3-Methoxytyramine3-Methoxy-4-hydroxyphenylethyl amine (see all 7)554-52-9--
    4,6-Dihydroxyquinoline4,6-Quinolinediol (see all 2)3517-61-1--
    5-Hydroxyindoleacetaldehyde(5-hydroxy-1H-indol-3-yl)acetaldehyde (see all 6)1892-21-3--
    5-Hydroxykynurenamine5-Hydroxykynuramine (see all 3)708-23-6--
    Aminoacetone1-Amino-2-propanone (see all 6)298-08-8--

    Selected DrugBank Compounds for MAOB (see all 41)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    PargylineBenzyl-methyl-2-propinylamin (see all 12)555-57-7targetinhibitor19300583 7995016 17823646 1794016 12199263 11978145 9564606 9673855 477738 16641841 17715422 19542488 6441926 16034956
    Tranylcypromine-- 155-09-9targetinhibitor12504917 8749840 15351283 15276688 10548268 14574774 11752352 20655983 16495723 10027835 15049511 10494892 9829163
    SelegilineL-Deprenalin (see all 4)14611-51-9targetinhibitor19300583 7995016 17823646 1794016 12199263 11978145 9673855 11752352 16641841 17715422 6441926 16034956
    Phenelzine-- 51-71-8targetantagonist17912044 14574774 11752352 7092487 19201819 16370964 18700056 9829163
    enzymesubstrate17912044 14574774 11752352 7092487 19201819 16370964 18700056 9829163 17768678 11752352
    Rasagiline-- 136236-51-6targetinhibitor19499843 19673610 20600573 20517484 11752352 20624440 12043833 15573406 18035186
    Phentermine-- 122-09-8targetantagonist11911838 11673765 10799660 10218558 10231134
    enzymeinhibitor11911838 11673765 10799660 10218558 10231134 11911838 10799660
    ZonisamideZonisamida [Spanish] (see all 2)68291-97-4targetinhibitor7856330 18782051 11755227 14965331 8991786 19948168 20502722
    FurazolidoneNitrofurazolidone (see all 3)67-45-8enzymeinhibitor12623758 2032659 10543364
    4-Methoxyamphetamine-- 23239-32-9targetinhibitor6103055 6646243
    DopamineDopamin (see all 6)51-61-6enzymesubstrate18652859 20869994

    Selected Novoseek inferred chemical compound relationships for MAOB gene (see all 129)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    selegiline 96.3 273 9243353 (5), 14628189 (5), 9564606 (4), 9260033 (4) (see all 99)
    rasagiline 95.5 117 15628826 (4), 16204711 (4), 16366596 (4), 16675649 (4) (see all 66)
    lazabemide 93.2 34 10927030 (3), 8665924 (3), 9056051 (3), 8489205 (2) (see all 19)
    propargylamine 88.9 11 16027398 (2), 14696044 (1), 7931256 (1), 18035186 (1) (see all 7)
    safinamide 88.5 26 17824599 (5), 15082032 (2), 17915852 (2), 12897643 (2) (see all 10)
    1,4-diphenyl-2-butene 88.4 8 15710600 (2), 14501143 (1), 12913124 (1), 17030739 (1) (see all 5)
    maoa 88.1 101 2023912 (4), 18391214 (4), 15050826 (3), 15211623 (3) (see all 45)
    beta-phenylethylamine 87.5 60 11797065 (5), 11160474 (4), 14628189 (3), 9326944 (2) (see all 31)
    desmethylselegiline 86.7 11 9243353 (7), 7981318 (1), 10682227 (1), 9260033 (1)
    n-(2-aminoethyl)-p-chlorobenzamide 85.8 4 7931243 (1), 9131670 (1), 15279562 (1)



    MAOB for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAOB gene: 
    NM_000898.4  

    Unigene Cluster for MAOB:

    Monoamine oxidase B
    Hs.654473  [show with all ESTs]
    Unigene Representative Sequence: NM_000898
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378069(uc011mkx.2 uc004dfz.4 uc011mky.2 uc010nhj.3)
    ENST00000487544 ENST00000468431 ENST00000536181 ENST00000538942
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MAOB using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MAOB:
    hsa-miR-618
    SwitchGear 3'UTR luciferase reporter plasmidMAOB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MAOB
    Predesigned siRNA for gene silencing in human, mouse, rat MAOB
    Clone
    Products:
         
    OriGene clones in human, mouse for MAOB (see all 7)
    OriGene ORF clones in mouse, rat for MAOB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAOB (NM_000898)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAOB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAOB
    Primer
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    OriGene qPCR primer pairs and template standards for MAOB
    OriGene qSTAR qPCR primer pairs in human, mouse for MAOB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAOB
      QuantiTect SYBR Green Assays in human, mouse, rat MAOB
      QuantiFast Probe-based Assays in human, mouse, rat MAOB

    Additional mRNA sequence: 

    AF088019.1 AK294306.1 AK298942.1 AK310458.1 AK312679.1 BC022494.1 M69177.1 S62734.1 

    7 DOTS entries:

    DT.95267653  DT.40112738  DT.95267654  DT.121287446  DT.75103384  DT.92427362  DT.40131695 

    Selected AceView cDNA sequences (see all 114):

    AA635647 BF939986 H23119 CF552693 BU681213 F31900 CF552692 AA363929 
    AI095601 S62734 BQ956448 AI769484 AL133791 BF970035 BM726427 CB216420 
    AI081909 BM666549 NM_000898 CA975968 AI127508 H23118 AI199665 BM680285 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAOB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACAAGGAAT
    MAOB Expression
    About this image


    MAOB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebellum
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             Liver Lobule
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Bone (Muscoskeletal System)
             Bone Marrow
    MAOB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAOB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654473
        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAOB: 
              Amino Acid Metabolism I in human mouse rat
              Hepatotoxicity in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MAOB gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Maob1 , 5 monoamine oxidase B1, 5 87.58(n)1
    89(a)1
      X (11.88 cM)5
    1097311  NM_172778.21  NP_766366.21 
     167092825 
    chicken
    (Gallus gallus)
    Aves MAOB1 monoamine oxidase B 74.57(n)
    75.34(a)
      418561  XM_416766.4  XP_416766.2 
    lizard
    (Anolis carolinensis)
    Reptilia MAOB6
    monoamine oxidase B
    73(a)
    1 ↔ 1
    3(135149801-135182394)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004942671 amine oxidase [flavin-containing]-like 72.96(n)
    75.14(a)
      100494267  XM_002932792.2  XP_002932838.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mao1 monoamine oxidase 68.53(n)
    69.88(a)
      404730  NM_212827.2  NP_997992.2 


    ENSEMBL Gene Tree for MAOB (if available)
    TreeFam Gene Tree for MAOB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAOB gene
    MAOA2  
    1 SIMAP similar gene for MAOB using alignment to 4 protein entries:     AOFB_HUMAN (see all proteins):
    MAOA

    MAOB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAOB (see all 1620)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1134946021,2
    C,F--43543924(+) ACTGAT/CGGTGG 1 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs10403991,2
    C,F,H--43543935(-) CCTCTT/CGACTC 1 -- ds500121Minor allele frequency- C:0.87NA EA MN NS 2546
    rs10403981,2
    C,F,A,H--43543967(-) TTAAAC/TGGTAT 1 -- ds500118--EA NA NS WA CSA 1846
    rs734720301,2
    C,F--43543985(+) TCCAAG/ATAGAA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1916115301,2
    --43544060(+) AGAAGC/GAATAT 1 -- ds50010--------
    rs1840725911,2
    --43544235(+) TATGCC/TACCCA 1 -- ds50010--------
    rs1889913601,2
    --43544256(+) TGCAAA/TCAAAT 1 -- ds50010--------
    rs30274361,2
    C,F--43544302(+) AAATGT/CTTTCA 1 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs2016521041,2
    C--43544358(+) AAAGC-/TTGAAA 1 -- ds50010--------
    rs1392744761,2
    --43544405(+) AATCAA/GCTTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for MAOB (43625857 - 43741721 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MAOB: --
    Human Gene Mutation Database (HGMD): MAOB
    Locus Specific Mutation Databases (LSDB): MAOB

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAOB
    DNA2.0 Custom Variant and Variant Library Synthesis for MAOB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 309860    OMIM disorders: --

    Selected diseases for MAOB (see all 67):    
    About MalaCards
    deep brain stimulation for parkinson's disease    norrie disease    substance abuse    hepatic encephalopathy
    psychotic disorder    restless legs syndrome    pathological gambling    multiple system atrophy
    antisocial personality disorder    personality disorder    memory impairment    tardive dyskinesia
    anxiety disorder    attention deficit hyperactivity disorder    cocaine abuse    turner syndrome
    phenylketonuria    mood disorder    fibromyalgia    cocaine dependence

    3 diseases from the University of Copenhagen DISEASES database for MAOB:
    Parkinson's disease     Toxic encephalopathy     Alzheimer's disease

    MAOB for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for MAOB gene (see all 56)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 86.8 252 10990520 (4), 11160474 (4), 8413955 (3), 18937611 (3) (see all 99)
    parkinsonism 67.3 30 2266365 (1), 1801542 (1), 10047935 (1), 11008487 (1) (see all 21)
    neurodegenerative diseases 62.8 22 10619718 (2), 8405291 (1), 9489486 (1), 17168653 (1) (see all 12)
    alzheimers disease 51.1 31 7816197 (3), 8815165 (2), 10867219 (2), 2222781 (1) (see all 22)
    neurodegeneration 47.9 12 16252076 (1), 17347320 (1), 12165403 (1), 12963742 (1) (see all 7)
    lewy body disease 43.8 1 18751929 (1)
    alcoholism 41.1 36 17592478 (3), 8154672 (2), 9622437 (2), 15918154 (1) (see all 18)
    crisis hypertensive 33.6 4 9829163 (1), 14697896 (1), 19527191 (1)
    akinesia 33 1 7593732 (1)
    gliosis 31 5 7931234 (1), 17624626 (1), 11586414 (1)

    Genatlas disease: MAOB
    monoamine oxidase deficiency

    Genetic Association Database (GAD): MAOB
    Human Genome Epidemiology (HuGE) Navigator: MAOB (67 documents)

    Export disorders for MAOB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAOB gene, integrated from 10 sources (see all 921):
    (articles sorted by number of sources associating them with MAOB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The lack of association between monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity among men. (PubMed id 16427095)1, 4, 9 Pivac N....Pavelic J. (Life Sci. 2006)
    2. The effect of monoamine oxidase B (MAOB) and catechol-O-methyltransferase (COMT) polymorphisms on levodopa therapy in patients with sporadic Parkinson's disease. (PubMed id 15355491)1, 4, 9 BiaA8ecka M....Stankiewicz J. (Acta Neurol. Scand. 2004)
    3. Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. (PubMed id 15710600)1, 2, 9 Hubalek F....Edmondson D.E. (J. Biol. Chem. 2005)
    4. Monoamine oxidase (MAO) intron 13 polymorphism and platelet MAO-B activity in combat-related posttraumatic stress disorder. (PubMed id 17289152)1, 4, 9 Pivac N....Muck-Seler D. (J Affect Disord 2007)
    5. High-level expression of human liver monoamine oxidase B in Pichia pastoris. (PubMed id 11049757)1, 2, 9 Newton-Vinson P.... Edmondson D.E. (Protein Expr. Purif. 2000)
    6. The deduced amino acid sequences of human platelet and frontal cortex monoamine oxidase B are identical. (PubMed id 8515265)1, 2, 9 Chen K.... Shih J.C. (J. Neurochem. 1993)
    7. Gene-gene interaction between FGF20 and MAOB in Parkinson disease. (PubMed id 18205889)1, 4, 9 Gao X....Martin E.R. (Ann. Hum. Genet. 2008)
    8. The association of monoamine oxidase B functional polymorphism with postoperative pain intensity. (PubMed id 16807522)1, 4, 9 SerA1 O....SevcA-k P. (Neuro Endocrinol. Lett. 2006)
    9. Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis. (PubMed id 16366596)1, 2, 9 Binda C....Mattevi A. (J. Med. Chem. 2005)
    10. Genotype combinations for monoamine oxidase-B intron 13 polymorphism and dopamine D2 receptor TaqIB polymorphism are associated with ever-smoking status among men. (PubMed id 15955630)1, 4, 9 Costa-Mallen P....Checkoway H. (Neurosci. Lett. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4129 HGNC: 6834 AceView: MAOB Ensembl:ENSG00000069535 euGenes: HUgn4129
    ECgene: MAOB Kegg: 4129 H-InvDB: MAOB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAOB Pharmacogenomics, SNPs, Pathways
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=MAOB
    Wikipedia http://en.wikipedia.org/wiki/Monoamine_oxidase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAOB gene:
    Search GeneIP for patents involving MAOB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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