MAOA Gene
protein-coding GIFtS : 71
GCID: GC0X P043515
monoamine oxidase A
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Aliasesfor MAOA gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Monoamine Oxidase A 1 2 Monoamine Oxidase Type A2 3 MAO-A2 3 EC 1.4.3.43 8 Amine Oxidase [Flavin-Containing] A2 EC 1.4.38
Export aliases for MAOA gene to outside databases Previous GC identifers: GC0XP041545 GC0XP041794 GC0XP042360 GC0XP042636 GC0XP043271 GC0XP043400 GC0XP041246
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Summariesfor MAOA gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MAOA : This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. (provided by RefSeq, Jul 2012) UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397 Function : Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in themetabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine summary
for MAOA : Monoamine Oxidases (MAO) catalyze the oxidation of monoamines such as dopamine, serotonin and adrenalin.They are found bound to the outer membrane of mitochondria in most cell types in the body. Two subtypes ofmonoamine oxidase have been identified: MAO-A and MAO-B. Both are found in neurons and astroglia, with MAO-Aalso found in the liver, gastrointestinal tract and placenta and MAO-B in blood platelets. Abnormalregulation of MAOs in the body has been associated with depression, substance abuse, attention deficitdisorder, and irregular sexual maturation. Gene Wiki entry for MAOA (Monoamine oxidase A)
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Genomic Viewsfor MAOA gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000023.10 NC_018934.1 NT_079573.4 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MAOA gene promoter: MEF-2A c-Fos AP-1 ATF-2 c-Jun Other transcription factors Search SABiosciences Chromatin IP Primers for MAOA Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MAOA
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xp11.3 Ensembl cytogenetic band: Xp11.3 HGNC cytogenetic band: Xp11.4-p11.3 MAOA Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XP043515: view genomic region
(about GC identifiers )
Start:
43,515,409 bp from pter
End:
43,606,068 bp from pter
Size:
90,660 bases
Orientation:
plus strand
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Proteinsfor MAOA gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397 (See
protein sequence )Recommended Name: Amine oxidase [flavin-containing] A Size : 527 amino acids; 59682 Da
Cofactor : FAD
Subunit : Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalentlybound flavin. Enzymatically active as monomer
Subcellular location : Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side
Mass spectrometry : Mass=60512; Mass_error=6; Method=Electrospray; Range=1-527; Source=PubMed:11812236;
5 PDB 3D structures from and Proteopedia for MAOA :1H8Q (3D)
  2BXR (3D)
  2BXS (3D)
  2Z5X (3D)
  2Z5Y (3D)
 
Secondary accessions : B4DF46 Q16426Alternative splicing : 2 isoforms : P21397-1 P21397-2 Explore the universe of human proteins at neXtProt for MAOA: NX_P21397 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P21397 4/22 DME Specific Peptides for MAOA (P21397 ) (see all 22 )MAOA Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_000231.1 NP_001257387.1 ENSEMBL proteins: ENSP00000340684 ENSP00000440846 Reactome Protein details: P21397 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
MAOA for ontologies About GeneDecksing MAOA Antibody Products: Assay Products for MAOA:
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Protein
Domains / Familiesfor MAOA gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MAOA for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P21397 ProtoNet protein and cluster: P21397
1 Blocks protein family : IPB001613 Flavin-containing amine oxidase signature UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397 Similarity : Belongs to the flavin monoamine oxidase family
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Functionfor MAOA gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397 Function : Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in themetabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine Catalytic activity : RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2)
Genatlas biochemistry entry for MAOA : monoamine oxidase A,overexpressed in female panic disorders Enzyme Numbers (IUBMB): EC 1.4.3.4 1 2 EC 1.4.3 2 Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MAOA (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MAOAOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MAOA (NM_000240 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAOA Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MAOA
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAOA
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008131 primary amine oxidase activity
TAS -- GO:0050660 flavin adenine dinucleotide binding
-- -- GO:0051378 serotonin binding
-- --
MAOA for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for MAOA :Animal Models: Mouse knock-out Maoa tm1Shih for MAOA 4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Maoa) :
MAOA for phenotypes About GeneDecksing
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Pathways & Interactionsfor MAOA gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/20 super-pathways (see all 20 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2 2 Tyrosine metabolism 3 Enzymatic degradation of dopamine by COMT 4 serotonin degradation 5 Transmission across Chemical Synapses
Pathway sources See GeneCards unified pathways Show all pathways 1 EMD Millipore Pathway for MAOA 1 GeneGo (Thomson Reuters) Pathway for MAOA 5/11 BioSystems Pathways for MAOA (see all 11 ) 5/15
Reactome Pathways for MAOA (see all 15 )1 PharmGKB Pathway for MAOA 5/8
Kegg Pathways (Kegg details for MAOA) (see all 8 ):
MAOA for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAOA STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/79 Interacting proteins for MAOA (P21397 2 , 3 ENSP00000340684 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 79 )About this table Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11 ): About this table
MAOA for ontologies About GeneDecksing
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Drugs & Compoundsfor MAOA gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
MAOA for compounds About GeneDecksing Compounds for MAOA available from Tocris Bioscience About this table 10/43 HMDB Compounds for MAOA (see all 43 ) About this table 10/37 DrugBank Compounds for MAOA (see all 37 ) About this table 10/133 Novoseek chemical compound relationships for MAOA gene (see all 133 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
maoa
98.5
1084
17692293 (10), 19224413 (8), 11927135 (8), 15936529 (8) (see all 99 )
moclobemide
94.9
153
1546132 (5), 8612391 (3), 9663810 (3), 9174681 (3) (see all 99 )
clorgyline
91.8
98
1741773 (4), 9564606 (3), 1893487 (3), 8243537 (2) (see all 54 )
brofaromine
90.8
33
8430214 (4), 1967018 (2), 8313400 (2), 8313393 (2) (see all 22 )
befloxatone
90.4
36
8613928 (8), 12729662 (3), 7665725 (2), 9728902 (2) (see all 15 )
kynuramine
89.7
14
20504539 (1), 8990278 (1), 16139309 (1), 8443155 (1) (see all 12 )
toloxatone
88.5
10
1546145 (2), 1705137 (2), 1424410 (2), 8713690 (1) (see all 6 )
tyramine
85.5
68
17561096 (4), 8255365 (3), 8695909 (2), 7665725 (2) (see all 37 )
pirlindole
83.5
16
8953568 (3), 9564636 (2), 12781338 (2), 9272198 (2) (see all 7 )
1-phenylcyclopropylamine
81.4
3
15755651 (1), 15848762 (1)
Search CenterWatch for drugs/clinical trials and news about MAOA / AOFA
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Transcriptsfor MAOA gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MAOA gene (2 alternative transcripts): NM_000240.3 NM_001270458.1 Unigene Cluster for MAOA:
Monoamine oxidase A Hs.183109 [show with all ESTs ] Unigene Representative Sequence: NM_001270458 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000338702 (uc004dfy.3 uc011mkw.2 ) ENST00000497485 ENST00000490604 ENST00000542639 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MAOA (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MAOAOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MAOA (NM_000240 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MAOA Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MAOA
Additional cDNA sequence: AK123241.1 AK223499.1 AK291769.1 AK293926.1 BC008064.2 BC044787.1 BT006651.1 M68840.1 X17192.1
11 DOTS entries : DT.95120451 DT.87015236
DT.101981844 DT.100025285 DT.100825058 DT.121278195 DT.100708824 DT.121278204 DT.95120454 DT.100718004 DT.70102839 24/267 AceView cDNA sequences (see all 267 ):
CD671543 R97085 BG534382 F02245 AW873998 R86250 AA865791 BQ716421 BM923944 BU684121 N30236 BC008064 AW511315 AA995668 AI624415 CB162010 N29331 AW627528 BX952460 AI159812 AI674356 H82430 BQ720697 BM127028 GeneLoc Exon Structure
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Expression for MAOA gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MAOA expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TCTGAAGTTT
About this image MAOA expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See MAOA Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MAOA SOURCE GeneReport for Unigene cluster: Hs.183109 UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397 Tissue specificity : Heart, liver, duodenum, blood vessels and kidney SABiosciences Expression via Pathway-Focused PCR Arrays including MAOA : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MAOABrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat MAOA QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MAOA QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MAOA In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAOA
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Orthologsfor MAOA gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for MAOA gene from 5/18 species (see all 18 ) About this table
ENSEMBL Gene Tree for MAOA (if available)TreeFam Gene Tree for MAOA (if available)
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Paralogsfor MAOA gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MAOA gene IL4I1 2 MAOB 2 1 SIMAP similar gene for MAOA using alignment to 7 protein entries: AOFA_HUMAN (see all proteins ):MAOB
MAOA for paralogs About GeneDecksing
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Genomic Variantsfor MAOA gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397 Polymorphism : A polymorphism 1.2 kb upstream of the MAOA coding sequences consists of a 30-bp repeated sequence presentin 3, 3.5, 4, or 5 copies. The polymorphism affect transcriptional activity of the MAOA gene promoter. Alleles with 3.5 or 4 copies of the repeat sequence are transcribed 2 to 10 times more efficiently than those with 3 or 5 copies of the repeat
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr X pos Sequence # AA Chg Type More # Allele freq Pop Total sample More