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MAOA Gene(Protein Coding)

Monoamine Oxidase A

GCID:
GC0XP043654
GIFtS:
71
Genes Participants
UDN Logo

Aliases for MAOA Gene

Aliases for MAOA Gene

  • Monoamine Oxidase A 2 3 5
  • Monoamine Oxidase Type A 3 4
  • EC 1.4.3.4 4 63
  • MAO-A 3 4
  • EC 1.4.3 63

External Ids for MAOA Gene

Previous GeneCards Identifiers for MAOA Gene

  • GC0XP041545
  • GC0XP041794
  • GC0XP042360
  • GC0XP042636
  • GC0XP043271
  • GC0XP043400
  • GC0XP043515
  • GC0XP041246

Summaries for MAOA Gene

Entrez Gene Summary for MAOA Gene

  • This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

GeneCards Summary for MAOA Gene

MAOA (Monoamine Oxidase A) is a Protein Coding gene. Diseases associated with MAOA include Brunner Syndrome and Maoa-Related Behavior Disorders. Among its related pathways are Histidine metabolism and Enzymatic degradation of dopamine by COMT. GO annotations related to this gene include oxidoreductase activity and primary amine oxidase activity. An important paralog of this gene is MAOB.

UniProtKB/Swiss-Prot for MAOA Gene

  • Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Tocris Summary for MAOA Gene

  • Monoamine Oxidases (MAO) catalyze the oxidation of monoamines such as dopamine, serotonin and adrenalin. They are found bound to the outer membrane of mitochondria in most cell types in the body. Two subtypes of MAO have been identified: MAO-A and MAO-B.

Gene Wiki entry for MAOA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAOA Gene

Genomics for MAOA Gene

Products:

  1. Regulatory Element

Regulatory Elements for MAOA Gene

Enhancers for MAOA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAOA on UCSC Golden Path with GeneCards custom track

Promoters for MAOA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAOA on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MAOA gene promoter:

Genomic Location for MAOA Gene

Chromosome:
X
Start:
43,654,907 bp from pter
End:
43,746,824 bp from pter
Size:
91,918 bases
Orientation:
Plus strand

Genomic View for MAOA Gene

Genes around MAOA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAOA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAOA Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MAOA Gene

Proteins for MAOA Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MAOA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21397-AOFA_HUMAN
    Recommended name:
    Amine oxidase [flavin-containing] A
    Protein Accession:
    P21397
    Secondary Accessions:
    • B4DF46
    • Q16426

    Protein attributes for MAOA Gene

    Size:
    527 amino acids
    Molecular mass:
    59682 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.

    Three dimensional structures from OCA and Proteopedia for MAOA Gene

    Alternative splice isoforms for MAOA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAOA Gene

Proteomics data for MAOA Gene at MOPED

Protein Expression for MAOA Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for MAOA Gene

P21397:

Post-translational modifications for MAOA Gene

  • Ubiquitination at Lys 469
  • Modification sites at PhosphoSitePlus

Other Protein References for MAOA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for MAOA Gene

Protein Domains for MAOA Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MAOA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P21397

UniProtKB/Swiss-Prot:

AOFA_HUMAN :
  • Belongs to the flavin monoamine oxidase family.
Family:
  • Belongs to the flavin monoamine oxidase family.
genes like me logo Genes that share domains with MAOA: view

No data available for Gene Families for MAOA Gene

Function for MAOA Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for MAOA Gene

GENATLAS Biochemistry:
monoamine oxidase A,overexpressed in female panic disorders
UniProtKB/Swiss-Prot CatalyticActivity:
RCH(2)NHR + H(2)O + O(2) = RCHO + RNH(2) + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Enzyme Numbers (IUBMB) for MAOA Gene

Gene Ontology (GO) - Molecular Function for MAOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051378 serotonin binding IEA --
genes like me logo Genes that share ontologies with MAOA: view

Phenotypes for MAOA Gene

MGI mutant phenotypes for MAOA:
inferred from 2 alleles
GenomeRNAi human phenotypes for MAOA:
genes like me logo Genes that share phenotypes with MAOA: view

Human Phenotype Ontology for MAOA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MAOA Gene

MGI Knock Outs for MAOA:

Animal Model Products

miRNA for MAOA Gene

miRTarBase miRNAs that target MAOA

Inhibitory RNA Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for MAOA Gene

Localization for MAOA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAOA Gene

Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAOA Gene COMPARTMENTS Subcellular localization image for MAOA gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 2
nucleus 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MAOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane TAS 24252804
genes like me logo Genes that share ontologies with MAOA: view

Pathways & Interactions for MAOA Gene

genes like me logo Genes that share pathways with MAOA: view

Interacting Proteins for MAOA Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000340684%0d%0a9606.ENSP00000456039%0d%0a9606.ENSP00000355920%0d%0a9606.ENSP00000280097%0d%0a9606.ENSP00000443432%0d%0a9606.ENSP00000350616%0d%0a
Selected Interacting proteins: P21397-AOFA_HUMAN ENSP00000340684 for MAOA Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for MAOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0007268 synaptic transmission TAS --
GO:0007269 neurotransmitter secretion TAS --
GO:0042133 neurotransmitter metabolic process TAS --
GO:0042135 neurotransmitter catabolic process IEA --
genes like me logo Genes that share ontologies with MAOA: view

No data available for SIGNOR curated interactions for MAOA Gene

Drugs & Compounds for MAOA Gene

Products:

  1. Drug

(100) Drugs for MAOA Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isocarboxazid Approved Pharma inhibitor, Target 2
Moclobemide Approved Pharma inhibitor, Target, Enzyme 5
Phenelzine Approved Pharma inhibitor, Target, Enzyme, antagonist, substrate 6
Selegiline Approved, Investigational Pharma inhibitor, Target 27
Tranylcypromine Approved Pharma inhibitor, Target 21

(97) Additional Compounds for MAOA Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Methoxytryptamine
  • 2-(5-Methoxy-1H-indol-3-yl)ethanamine
  • 2-(5-Methoxyindol-3-yl)ethylamine
  • 3-(2-Aminoethyl)-5-methoxyindole
  • 5-Mot
  • 5MOT
 608-07-1
Normetanephrine
  • (+/-)-alpha-(aminomethyl)-4-hydroxy-3-methoxy-Benzenemethanol
  • (+/-)-Normetanephrine
  • 3-Methoxy-Noradrenaline
  • 3-O-Methyl-Noradrenaline
  • 4-(2-Amino-1-hydroxyethyl)-2-methoxyphenol
 97-31-4
1-Methylhistamine
  • 1-Methyl-1H-imidazole-4-ethanamine
  • 1-Methyl-4-(2-aminoethyl)imidazole
  • 1-Methyl-4-(b-aminoethyl)imidazole
  • 1-Methyl-4-(beta-aminoethyl)imidazole
  • 1-Methyl-4-histamine
 501-75-7
1-Phenylethylamine
  • (1-Aminoethyl)benzene
  • 1-Amino-1-phenylethane
  • 1-Fenylethylamin
  • 1-Phenyl-1-ethanamine
  • 1-Phenylethanamine
 98-84-0
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
  • 3,4-Dihydroxyphenylglycolic aldehyde
  • a,3,4-Trihydroxy-Benzeneacetaldehyde
  • alpha,3,4-Trihydroxy-Benzeneacetaldehyde
 13023-73-9

(5) Tocris Compounds for MAOA Gene

Compound Action Cas Number
(R)-(-)-Deprenyl hydrochloride MAO-B inhibitor 14611-52-0
Bifemelane hydrochloride MAO-A and MAO-B inhibitor 62232-46-6
Harmane Putative endogenous imidazoline ligand. Also MAO inhibitor 486-84-0
Pirlindole mesylate MAO-A inhibitor 207572-66-5
Tetrindole mesylate MAO-A inhibitor 170964-68-8

(4) ApexBio Compounds for MAOA Gene

Compound Action Cas Number
Moclobemide (Ro 111163) Reversible inhibitor of MAO-A 71320-77-9
Paeonol MAO inhibitor;multi-functional phenolic compound 552-41-0
Procarbazine HCl Antineoplastic chemotherapy drug 366-70-1
Sennoside A Irritant laxative;mild MAO inhibitor 81-27-6
genes like me logo Genes that share compounds with MAOA: view

Transcripts for MAOA Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for MAOA Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(267) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MAOA Gene

Monoamine oxidase A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAOA Gene

No ASD Table

Relevant External Links for MAOA Gene

GeneLoc Exon Structure for
MAOA
ECgene alternative splicing isoforms for
MAOA

Expression for MAOA Gene

Products:

  1. Primer

mRNA expression in normal human tissues for MAOA Gene

mRNA expression in normal human tissues for MAOA Gene
mRNA expression by BioGPS for MAOA GenemRNA expression by GTEx for MAOA Gene

Protein differential expression in normal tissues from HIPED for MAOA Gene

This gene is overexpressed in Placenta (12.0), Nasal epithelium (9.2), Nasopharynx (7.5), and Adipocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAOA Gene



SOURCE GeneReport for Unigene cluster for MAOA Gene Hs.183109

mRNA Expression by UniProt/SwissProt for MAOA Gene

P21397-AOFA_HUMAN
Tissue specificity: Heart, liver, duodenum, blood vessels and kidney.
genes like me logo Genes that share expression patterns with MAOA: view

Protein tissue co-expression partners for MAOA Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for MAOA Gene

Orthologs for MAOA Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAOA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia MAOA 35
  • 84.95 (n)
  • 88.05 (a)
MAOA 36
  • 88 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia MAOA 35
  • 86.65 (n)
  • 89.75 (a)
MAOA 36
  • 90 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Maoa 35
  • 85.19 (n)
  • 88.12 (a)
Maoa 16
Maoa 36
  • 87 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia LOC743285 35
  • 98.8 (n)
  • 98.89 (a)
MAOA 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Maoa 35
  • 84.57 (n)
  • 88 (a)
oppossum
(Monodelphis domestica)
 Mammalia MAOA 36
  • 73 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia MAOA 36
  • 79 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MAOA 36
  • 72 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia MAOA 36
  • 72 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100495198 35
  • 68.62 (n)
  • 70.76 (a)
zebrafish
(Danio rerio)
 Actinopterygii mao 36
  • 69 (a)
 OneToMany
Species with no ortholog for MAOA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAOA Gene

ENSEMBL:
Gene Tree for MAOA (if available)
TreeFam:
Gene Tree for MAOA (if available)

Paralogs for MAOA Gene

Paralogs for MAOA Gene

(1) SIMAP similar genes for MAOA Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MAOA: view

Variants for MAOA Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MAOA Gene

AOFA_HUMAN-P21397
A polymorphism 1.2 kb upstream of the MAOA coding sequences consists of a 30-bp repeated sequence present in 3, 3.5, 4, or 5 copies. The polymorphism affect transcriptional activity of the MAOA gene promoter. Alleles with 3.5 or 4 copies of the repeat sequence are transcribed 2 to 10 times more efficiently than those with 3 or 5 copies of the repeat.

Sequence variations from dbSNP and Humsavar for MAOA Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1799835 - 43,731,838(+) AGGCC(G/T)TCTGG reference, missense
rs1800466 - 43,744,488(+) GTACA(A/G)ATACA reference, missense
VAR_036545 A breast cancer sample
rs77698881 - 43,728,231(+) CTCAC(A/G)AAGTG reference, missense
VAR_071963 -

Structural Variations from Database of Genomic Variants (DGV) for MAOA Gene

Variant ID Type Subtype PubMed ID
nsv517873 CNV Gain 19592680
esv21483 CNV Gain 19812545

Variation tolerance for MAOA Gene

Residual Variation Intolerance Score: 18.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAOA Gene

Human Gene Mutation Database (HGMD)
MAOA

Disorders for MAOA Gene

MalaCards: The human disease database

(59) MalaCards diseases for MAOA Gene - From: OMIM, ClinVar, GeneTests, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MAOA in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

AOFA_HUMAN
  • Brunner syndrome (BRUNS) [MIM:300615]: A form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. {ECO:0000269 PubMed:8211186}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MAOA

Genetic Association Database (GAD)
MAOA
Human Genome Epidemiology (HuGE) Navigator
MAOA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAOA
genes like me logo Genes that share disorders with MAOA: view

No data available for Genatlas for MAOA Gene

Publications for MAOA Gene

  1. A non-additive interaction of a functional MAO-A VNTR and testosterone predicts antisocial behavior. (PMID: 17429405) SjAPberg R.L. … Goldman D. (Neuropsychopharmacology 2008) 3 23 25 26
  2. Early trauma and increased risk for physical aggression during adulthood: the moderating role of MAOA genotype. (PMID: 17534436) Frazzetto G. … Troisi A. (PLoS ONE 2007) 3 23 48 67
  3. Amine oxidases and monooxygenases in the in vivo metabolism of xenobiotic amines in humans: has the involvement of amine oxidases been neglected? (PMID: 17868200) Strolin Benedetti M. … Whomsley R. (Fundam Clin Pharmacol 2007) 23 25 26
  4. Transdermal selegiline for the treatment of major depressive disorder. (PMID: 19300583) Lee K.C. … Chen J.J. (Neuropsychiatr Dis Treat 2007) 23 25 26
  5. Transdermal selegiline: the new generation of monoamine oxidase inhibitors. (PMID: 16641841) Patkar A.A. … Masand P.S. (CNS Spectr 2006) 23 25 26

Products for MAOA Gene

Sources for MAOA Gene

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