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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAOA Gene

protein-coding   GIFtS: 71
GCID: GC0XP043515

monoamine oxidase A

 Explore 111 diseases affiliated with
MAOA via our new
 Human Malady Compendium 
Biological research products
for MAOA
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Monoamine Oxidase A1 2
Monoamine Oxidase Type A2 3
MAO-A2 3
EC 1.4.3.43 8
Amine Oxidase [Flavin-Containing] A2
EC 1.4.38

External Ids:    HGNC: 68331   Entrez Gene: 41282   Ensembl: ENSG000001892217   OMIM: 3098505   UniProtKB: P213973   

Export aliases for MAOA gene to outside databases

Previous GC identifers: GC0XP041545 GC0XP041794 GC0XP042360 GC0XP042636 GC0XP043271 GC0XP043400 GC0XP041246


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAOA:
This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative
deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner
syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial
behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. (provided by
RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397
Function: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the
metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA
preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine

summary for MAOA:
Monoamine Oxidases (MAO) catalyze the oxidation of monoamines such as dopamine, serotonin and adrenalin.
They are found bound to the outer membrane of mitochondria in most cell types in the body. Two subtypes of
monoamine oxidase have been identified: MAO-A and MAO-B. Both are found in neurons and astroglia, with MAO-A
also found in the liver, gastrointestinal tract and placenta and MAO-B in blood platelets. Abnormal
regulation of MAOs in the body has been associated with depression, substance abuse, attention deficit
disorder, and irregular sexual maturation.

Gene Wiki entry for MAOA (Monoamine oxidase A)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_079573.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAOA gene promoter:
         MEF-2A   c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAOA promoter sequence
   Search SABiosciences Chromatin IP Primers for MAOA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAOA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.3   Ensembl cytogenetic band:  Xp11.3   HGNC cytogenetic band: Xp11.4-p11.3

MAOA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAOA gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP043515:  view genomic region     (about GC identifiers)

Start:
43,515,409 bp from pter      End:
43,606,068 bp from pter
Size:
90,660 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397 (See protein sequence)
Recommended Name: Amine oxidase [flavin-containing] A  
Size: 527 amino acids; 59682 Da
Cofactor: FAD
Subunit: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently
bound flavin. Enzymatically active as monomer
Subcellular location: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side
Mass spectrometry: Mass=60512; Mass_error=6; Method=Electrospray; Range=1-527; Source=PubMed:11812236;
5 PDB 3D structures from and Proteopedia for MAOA:
1H8Q (3D)        2BXR (3D)        2BXS (3D)        2Z5X (3D)        2Z5Y (3D)    
Secondary accessions: B4DF46 Q16426
Alternative splicing: 2 isoforms:  P21397-1   P21397-2   

Explore the universe of human proteins at neXtProt for MAOA: NX_P21397

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P21397

  • 4/22 DME Specific Peptides for MAOA (P21397) (see all 22)
     RQPVGRI  DYNNLWR  ERNLPSV  FPPVWNP 

    MAOA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_000231.1  NP_001257387.1  

    ENSEMBL proteins: 
     ENSP00000340684   ENSP00000440846  
    Reactome Protein details: P21397
    Human Recombinant Protein Products: 
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    Uscn Proteins for MAOA

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005739mitochondrion ----
    GO:0005741mitochondrial outer membrane TAS--
    GO:0016021integral to membrane IEA--


    MAOA for ontologies           About GeneDecksing



    MAOA Antibody Products: 
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    Uscn ELISAs and CLIAs for MAOA


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MAOA for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001613 Flavin_amine_oxidase
     IPR002937 Amino_oxidase

    Graphical View of Domain Structure for InterPro Entry P21397

    ProtoNet protein and cluster: P21397

    1 Blocks protein family: IPB001613 Flavin-containing amine oxidase signature

    UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397
    Similarity: Belongs to the flavin monoamine oxidase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397
    Function: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the
    metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA
    preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine
    Catalytic activity: RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2)

         Genatlas biochemistry entry for MAOA:
    monoamine oxidase A,overexpressed in female panic disorders

    Enzyme Numbers (IUBMB): EC 1.4.3.41 2 EC 1.4.32

    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate MAOA (see all 13):
    hsa-miR-3163 hsa-miR-495 hsa-miR-767-3p hsa-miR-7-2* hsa-miR-1324 hsa-miR-3065-5p hsa-miR-624* hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidMAOA 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008131primary amine oxidase activity TAS--
    GO:0050660flavin adenine dinucleotide binding ----
    GO:0051378serotonin binding ----


    MAOA for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MAOA:
     Decreased viability 

    Animal Models:
         Mouse knock-out Maoatm1Shih for MAOA
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Maoa):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  nervous system 

    MAOA for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/20 super-pathways (see all 20About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2
    Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O21.00
    Metabolism of serotonin0.33
    melatonin degradation II1.00
    Serotonin clearance from the synaptic cleft0.33
    Amine Oxidase reactions0.50
    phenylalanine degradation IV (mammalian, via side chain)0.29
    tryptophan degradation X (mammalian, via tryptamine)0.40
    putrescine degradation III0.20
    2Tyrosine metabolism
    Tyrosine metabolism1.00
    Tyrosine metabolism p.1 (dopamine) 0.28
    Phenylalanine metabolism0.35
    Tyrosine metabolism p.1 (dopamine)0.28
    3Enzymatic degradation of dopamine by COMT
    Enzymatic degradation of dopamine by COMT1.00
    Dopamine clearance from the synaptic cleft0.67
    Enzymatic degradation of Dopamine by monoamine oxidase1.00
    Neurotransmitter Clearance In The Synaptic Cleft0.29
    4serotonin degradation
    serotonin degradation1.00
    noradrenaline and adrenaline degradation0.40
    dopamine degradation0.58
    5Transmission across Chemical Synapses
    Transmission across Chemical Synapses1.00
    Neuronal System0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for MAOA
        Tyrosine metabolism p.1 (dopamine)


    1 GeneGo (Thomson Reuters) Pathway for MAOA
        Tyrosine metabolism p.1 (dopamine)

    5/11 BioSystems Pathways for MAOA (see all 11
        SIDS Susceptibility Pathways
    Biogenic Amine Synthesis
    dopamine degradation
    phenylalanine degradation IV (mammalian, via side chain)
    putrescine degradation III

    5/15        Reactome Pathways for MAOA (see all 15)
        Enzymatic degradation of dopamine by COMT
    Metabolism of serotonin
    Serotonin clearance from the synaptic cleft
    Enzymatic degradation of Dopamine by monoamine oxidase
    Transmission across Chemical Synapses

    1 PharmGKB Pathway for MAOA
        Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    5/8         Kegg Pathways  (Kegg details for MAOA) (see all 8):
        Glycine, serine and threonine metabolism
    Arginine and proline metabolism
    Histidine metabolism
    Tyrosine metabolism
    Phenylalanine metabolism


    MAOA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAOA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/79 Interacting proteins for MAOA (P213972, 3 ENSP000003406844) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    NDRG1Q925973, ENSP000003199774I2D: score=3 STRING: ENSP00000319977
    ATP6V1B2P212812, ENSP000002763904MINT-4054731 STRING: ENSP00000276390
    YWHABP319463I2D: score=1 
    A2MP010232MINT-4054731
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006576cellular biogenic amine metabolic process TAS8211186
    GO:0006805xenobiotic metabolic process TAS--
    GO:0007268synaptic transmission TAS--
    GO:0007269neurotransmitter secretion TAS--
    GO:0007610behavior TAS8211186


    MAOA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAOA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MAOA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Tetrindole mesylateMAO-A inhibitor[135991-95-6]
    Pirlindole mesylateMAO-A inhibitor[60762-57-4]
    HarmanePutative endogenous imidazoline ligand. Also MAO inhibitor[486-84-0]
    Bifemelane hydrochlorideMAO-A and MAO-B inhibitor[90293-01-9]

    10/43 HMDB Compounds for MAOA (see all 43)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Methylhistamine1-Methyl-1H-imidazole-4-ethanamine (see all 21)501-75-7--
    1-Phenylethylaminea-phenylethylamine (see all 17)98-84-0--
    3,4-Dihydroxymandelaldehyde3,4-Dihydroxyphenylglycolaldehyde (see all 4)13023-73-9--
    3,4-DihydroxyphenylacetaldehydeProtocatechuatealdehyde (see all 2)5707-55-1--
    3-Methoxy-4-hydroxyphenylglycolaldehydea,4-dihydroxy-3-methoxy-Benzeneacetaldehyde (see all 4)17592-23-3--
    3-Methoxytyramine3-Methoxy-4-hydroxyphenylethyl amine (see all 7)554-52-9--
    4,6-Dihydroxyquinoline4,6-Quinolinediol (see all 2)3517-61-1--
    5-Hydroxyindoleacetaldehyde(5-hydroxy-1H-indol-3-yl)acetaldehyde (see all 6)1892-21-3--
    5-Hydroxykynurenamine5-Hydroxykynuramine (see all 3)708-23-6--
    5-Methoxytryptamine2-(5-Methoxy-1H-indol-3-yl)ethanamine (see all 10)608-07-1--

    10/37 DrugBank Compounds for MAOA (see all 37)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Tranylcypromine-- 155-09-9targetinhibitor12504917 8749840 15351283 15276688 10548268 14574774 11752352 20655983 16495723 10027835 15049511 10494892 9829163
    Phenelzine-- 51-71-8targetantagonist17768678 17912044 14574774 11752352 7092487 19201819 16370964 18700056 9829163
    enzymesubstrate17768678 17912044 14574774 11752352 7092487 19201819 16370964 18700056 9829163 17768678
    PargylineBenzyl-methyl-2-propinylamin (see all 12)555-57-7targetinhibitor19300583 17823646 9564606 477738 16641841 17715422
    Phentermine(alpha,alpha)-Dimethylphenethylamine (see all 3)122-09-8targetantagonist11911838 11673765 10799660 10231134
    enzymeinhibitor11911838 11673765 10799660 10231134 11911838 10799660
    Moclobemide4-Chlor-N-(2-morpholinoethyl)benzamid (see all 11)71320-77-9targetinhibitor1705137 8875133 11752352
    enzymeinhibitor1705137 8875133 11752352 11752352
    SelegilineL-Deprenalin (see all 4)14611-51-9targetinhibitor19300583 17823646 16641841 17715422
    Almotriptan-- 181183-52-8enzymesubstrate12353056 12642466 15762767
    DopamineDopamin (see all 6)51-61-6enzymesubstrate15817751 18652859 20869994
    Flavin-Adenine Dinucleotide-- 146-14-5target--17139284 17016423 10592235
    FurazolidoneNitrofurazolidone (see all 3)67-45-8enzymeinhibitor12623758 2032659 10543364

    10/133 Novoseek chemical compound relationships for MAOA gene (see all 133)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    maoa 98.5 1084 17692293 (10), 19224413 (8), 11927135 (8), 15936529 (8) (see all 99)
    moclobemide 94.9 153 1546132 (5), 8612391 (3), 9663810 (3), 9174681 (3) (see all 99)
    clorgyline 91.8 98 1741773 (4), 9564606 (3), 1893487 (3), 8243537 (2) (see all 54)
    brofaromine 90.8 33 8430214 (4), 1967018 (2), 8313400 (2), 8313393 (2) (see all 22)
    befloxatone 90.4 36 8613928 (8), 12729662 (3), 7665725 (2), 9728902 (2) (see all 15)
    kynuramine 89.7 14 20504539 (1), 8990278 (1), 16139309 (1), 8443155 (1) (see all 12)
    toloxatone 88.5 10 1546145 (2), 1705137 (2), 1424410 (2), 8713690 (1) (see all 6)
    tyramine 85.5 68 17561096 (4), 8255365 (3), 8695909 (2), 7665725 (2) (see all 37)
    pirlindole 83.5 16 8953568 (3), 9564636 (2), 12781338 (2), 9272198 (2) (see all 7)
    1-phenylcyclopropylamine 81.4 3 15755651 (1), 15848762 (1)

    Search CenterWatch for drugs/clinical trials and news about MAOA / AOFA 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAOA gene (2 alternative transcripts): 
    NM_000240.3  NM_001270458.1  

    Unigene Cluster for MAOA:

    Monoamine oxidase A
    Hs.183109  [show with all ESTs]
    Unigene Representative Sequence: NM_001270458
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338702(uc004dfy.3 uc011mkw.2) ENST00000497485 ENST00000490604
    ENST00000542639

    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate MAOA (see all 13):
    hsa-miR-3163 hsa-miR-495 hsa-miR-767-3p hsa-miR-7-2* hsa-miR-1324 hsa-miR-3065-5p hsa-miR-624* hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidMAOA 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK123241.1 AK223499.1 AK291769.1 AK293926.1 BC008064.2 BC044787.1 BT006651.1 M68840.1 
    X17192.1 

    11 DOTS entries:

    DT.95120451  DT.87015236  DT.101981844  DT.100025285  DT.100825058  DT.121278195  DT.100708824  DT.121278204 
    DT.95120454  DT.100718004  DT.70102839 

    24/267 AceView cDNA sequences (see all 267):

    CD671543 R97085 BG534382 F02245 AW873998 R86250 AA865791 BQ716421 
    BM923944 BU684121 N30236 BC008064 AW511315 AA995668 AI624415 CB162010 
    N29331 AW627528 BX952460 AI159812 AI674356 H82430 BQ720697 BM127028 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAOA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTGAAGTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    MAOA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Alveolar type II cells (Derivation of mature...)Lung
    HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)Adipose
    TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)Bone, Cartilage
    HyStem+BMP4-induced E15 cells (HyStem+BMP4 inductio...)Adipose, Bone, Cartilage

    See MAOA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAOA

    SOURCE GeneReport for Unigene cluster: Hs.183109

    UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397
    Tissue specificity: Heart, liver, duodenum, blood vessels and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAOA: 
              Amino Acid Metabolism II in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAOA
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAOA
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAOA
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAOA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAOA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MAOA gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves MAOA6
    monoamine oxidase A
    73(a)
    1 ↔ 1
    1(114866376-114910104)
    lizard
    (Anolis carolinensis)
    Reptilia MAOA6
    --
    71(a)
    1 ↔ 1
    3(135093798-135122255)
    zebrafish
    (Danio rerio)
    Actinopterygii mao6
    si:ch211-127i16.26
    si:ch211-127i16.2
    69(a)
    33(a)
    1 ↔ many
    possible ortholog
    9(34618751-34683759)
    10(19461623-19528134)
    honey bee
    (Apis mellifera)
    Insecta --
    --
    17(a)
    possible ortholog
    Group16.2(433804-436374)
    worm
    (Caenorhabditis elegans)
    Secernentea amx-26
    AMine oXidase family member (amx-2)
    13(a)
    possible ortholog
    I(12759576-12764950)


    ENSEMBL Gene Tree for MAOA (if available)
    TreeFam Gene Tree for MAOA (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAOA gene
    IL4I12  MAOB2  
    1 SIMAP similar gene for MAOA using alignment to 7 protein entries:     AOFA_HUMAN (see all proteins):
    MAOB

    MAOA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397
    Polymorphism: A polymorphism 1.2 kb upstream of the MAOA coding sequences consists of a 30-bp repeated sequence present
    in 3, 3.5, 4, or 5 copies. The polymorphism affect transcriptional activity of the MAOA gene promoter. Alleles with
    3.5 or 4 copies of the repeat sequence are transcribed 2 to 10 times more efficiently than those with 3 or 5 copies of
    the repeat


    890/907 NCBI SNPs in MAOA are shown (see all 907    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs725546321,2
    Cpathogenic43591031(+) TAATTC/TAGCGG 4 Q * stg10--------
    rs1923952121,2
    --43512260(+) AGGATC/TGAGGC 2 -- us2k10--------
    rs66518041,2
    C,--43512290(+) caGTCA/GGCCTC 2 -- us2k12Minor allele frequency- G:0.00WA CSA 3
    rs66518051,2
    C,--43512293(+) TCGGCT/CTCAGC 2 -- us2k12Minor allele frequency- C:0.00WA CSA 3
    rs48246571,2
    C,F,A,H,--43512302(+) GCAGCC/GTTGTC 2 -- us2k110Minor allele frequency- G:0.32NA WA CSA 19
    rs1904159451,2
    --43512369(+) TTTTTC/TCTACC 2 -- us2k10--------
    rs1118209341,2
    C,--43512512(+) ACATTC/TGTCAG 2 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs1816096531,2
    --43512744(+) GATTTC/TTTCAT 2 -- us2k10--------
    rs1843172791,2
    --43512882(+) CATATG/TTCTTT 2 -- us2k10--------
    rs1890954131,2
    --43512904(+) AACAAA/GATGTT 2 -- us2k10--------
    rs736330151,2
    C,--43512980(+) TCCTCC/GAGTTC 2 -- us2k12Minor allele frequency- G:0.00WA CSA 3
    rs1811407181,2
    --43513085(+) ATGGCA/GCGATC 2 -- us2k10--------
    rs1855863721,2
    --43513086(+) TGGCGC/TGATCT 2 -- us2k10--------
    rs1909237721,2
    --43513162(+) GGGATC/TACAGG 2 -- us2k10--------
    rs1809320931,2
    --43513274(+) CGCCTC/TGGCCT 2 -- us2k10--------
    rs1872237841,2
    --43513286(+) CCAAAA/GTGCCG 2 -- us2k10--------
    rs1467199001,2
    C,--43513351(+) TCCAGC/TAATGA 2 -- us2k10--------
    rs1919814541,2
    --43513396(+) AAAAAG/TTGGAA 2 -- us2k10--------
    rs1842436081,2
    --43513578(+) GATAGA/GTGAGT 2 -- us2k10--------
    rs574113561,2
    C,--43513808(+) CCCGCT/CCCTCC 2 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1874973111,2
    --43514041(+) CTACAC/TCCACG 2 -- us2k10--------
    rs59532101,2
    C,F,H,--43514046(+) CCCACA/GTCTAC 2 -- us2k119Minor allele frequency- G:0.40NS EA NA WA CSA 1991
    rs1907812211,2
    --43514057(+) TCCCCC/GACTCT 2 -- us2k10--------
    rs1997606051,2
    --43514419(+) CACCG-/GCACC 
     AGTACCC
    GCACC
    2 -- ut510--------
    rs1825643991,2
    --43514856(+) CGCCCG/TTAAAC 2 -- ut510--------
    rs174360541,2
    C--43515013(+) ACCCAA/GTGACC 2 -- ut512Minor allele frequency- G:0.00NA 4
    rs1872234331,2
    --43515345(+) ACAAGA/GGTCCG 2 -- ut510--------
    rs1925494441,2
    --43515516(+) GGAGTC/TGATAG 2 -- ut510--------
    rs1843517161,2
    --43515719(+) GGGGAA/GCCTAC 2 -- int10--------
    rs1432219851,2
    --43515952(+) TCAGTC/TCTCAA 2 -- int10--------
    rs1880481671,2
    --43516091(+) ATTTAA/GGACCT 2 -- int10--------
    rs1930801611,2
    --43516191(+) ATTGAG/TGGAGC 2 -- int10--------
    rs1848197021,2
    --43516268(+) AGGTAA/GACTCC 2 -- int10--------
    rs30300711,2
    C--43516538(+) TATAT-/ATAT  
            
    GAACT
    2 -- int10--------
    rs1888504371,2
    --43516590(+) GGACAC/TTTATT 2 -- int10--------
    rs1390515571,2
    C,--43516639(+) CCCTGC/TTGTAT 2 -- int10--------
    rs1418408491,2
    --43517259(+) TTTATG/TTATGT 2 -- int10--------
    rs37888621,2
    C,F,A,H,--43517364(+) AAGCAA/GTATGG 2 -- int117Minor allele frequency- G:0.56EA NS NA WA CSA 636
    rs1921883801,2
    --43517575(+) CTGCTC/TTTCCT 2 -- int10--------
    rs1838579001,2
    --43517790(+) TGTAGA/GTCCCA 2 -- int10--------
    rs1896143421,2
    --43517838(+) AATTTA/TTTTCC 2 -- int10--------
    rs1806879321,2
    --43517842(+) TATTTC/TCATTT 2 -- int10--------
    rs1859514571,2
    --43517844(+) TTTCCA/TTTTGG 2 -- int10--------
    rs125566941,2
    C,H,--43518067(+) TGGCTC/TGTGTT 2 -- int14Minor allele frequency- T:0.00NS EA 416
    rs1818874521,2
    --43518105(+) ATGAGA/CGGGTG 2 -- int10--------
    rs59057021,2
    C,F,A,H,--43518188(+) ATGAAT/GTACTT 2 -- int119Minor allele frequency- G:0.48NS EA NA WA CSA 1967
    rs1864980121,2
    --43518192(+) ATTACA/TTAATA 2 -- int10--------
    rs1419240411,2
    --43518337(+) AGCACC/GCAGAA 2 -- int10--------
    rs1506678771,2
    --43518457(+) CATTAG/TAAAAC 2 -- int10--------
    rs1379692801,2
    --43518458(+) ATTATA/GAAACA 2 -- int10--------
    rs1904910591,2
    --43518478(+) CTATGC/TCTTAC 2 -- int10--------
    rs1830615721,2
    --43518564(+) ATAACC/GCTGCT 2 -- int10--------
    rs1862983981,2
    --43518982(+) CAATCC/TAGCTT 2 -- int10--------
    rs65208931,2
    C,H,--43519176(+) TAAAAA/GTATTT 2 -- int17Minor allele frequency- G:0.01NS WA NA CSA 188
    rs1834254301,2
    --43519494(+) AAAAGC/TTCTTG 2 -- int10--------
    rs1875476321,2
    --43519675(+) CAGCCC/TCCCAA 2 -- int10--------
    rs1927702211,2
    --43519680(+) TCCCAA/GACACC 2 -- int10--------
    rs1494886741,2
    --43519688(+) ACCTCC/TCTATC 2 -- int10--------
    rs1831471771,2
    --43519696(+) ATCCCA/GCCCCC 2 -- int10--------
    rs1459358241,2
    --43519786(+) CACTAC/TGTTTA 2 -- int10--------
    rs1878185681,2
    --43519997(+) ATTTCA/GTGATT 2 -- int10--------
    rs1919227891,2
    --43520082(+) AATGAC/TAGAAA 2 -- int10--------
    rs1843494321,2
    --43520211(+) CCTTCA/GTGAGT 2 -- int10--------
    rs1398286541,2
    --43520335(+) TGTAGC/TTTTGA 2 -- int10--------
    rs1904295511,2
    --43520343(+) TGAACA/GCATTT 2 -- int10--------
    rs59067291,2
    C,F,A,H,--43520371(+) GGTCTC/GTCAAA 2 -- int110Minor allele frequency- G:0.49NS EA NA WA CSA 427
    rs1926839861,2
    --43520526(+) AAGGTA/TCTTCT 2 -- int10--------
    rs1850331671,2
    --43520650(+) TTTGAA/GTATGA 2 -- int10--------
    rs171466601,2
    C,F,H,--43520782(+) GCCAGA/TTATGA 2 -- int110Minor allele frequency- T:0.04NA NS EA WA CSA 435
    rs1890965491,2
    --43520942(+) TTAGCA/GAGCGC 2 -- int10--------
    rs1809214011,2
    --43521044(+) GTCACA/GTAGAA 2 -- int10--------
    rs1862966331,2
    --43521090(+) GAACTA/CCTCTC 2 -- int10--------
    rs1129587851,2
    C,--43521312(+) TAAAAG/ATTATT 2 -- int11Minor allele frequency- A:0.00CSA 1
    rs1894728001,2
    --43521337(+) TTAGGA/CATTTT 2 -- int10--------
    rs66108341,2
    C,--43521681(+) ATTTTA/GGCATT 2 -- int10--------
    rs1509894901,2
    --43521995(+) TAGACA/CCCCGA 2 -- int10--------
    rs78802301,2
    C,F,H,--43522021(+) GAATAT/CACTTG 2 -- int18Minor allele frequency- C:0.18NS NA WA CSA 893
    rs1820753371,2
    --43522106(+) CAAAAC/TATTTT 2 -- int10--------
    rs1447560341,2
    --43522374(+) AGATCC/TGTCTC 2 -- int10--------
    rs1867118271,2
    --43522398(+) CTTGGA/TCCCTC 2 -- int10--------
    rs1478705041,2
    --43522409(+) CTCAAC/TGTTTT 2 -- int10--------
    rs1920140931,2
    --43522423(+) CTTCTA/GTGCTT 2 -- int10--------
    rs1828976761,2
    --43522616(+) TAATTA/GATTGA 2 -- int10--------
    rs1131868451,2
    C,--43522717(+) GGCCTA/GTAAGA 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs1866510871,2
    --43522821(+) AAATAC/TTGACT 2 -- int10--------
    rs1895823621,2
    --43522969(+) ATTTAC/TATATT 2 -- int10--------
    rs732111891,2
    C,--43523226(+) TTTTAC/TGCATA 2 -- int10--------
    rs1822337081,2
    --43523427(+) CATTCA/CGGCTG 2 -- int10--------
    rs1875521691,2
    --43523597(+) TTTAAA/TGTATC 2 -- int10--------
    rs1908840111,2
    --43523845(+) TGAAGA/TTGACC 2 -- int10--------
    rs1834325131,2
    --43523941(+) TTCATC/TCATTC 2 -- int10--------
    rs1477333211,2
    --43524316(+) AACTAA/GGCAGG 2 -- int10--------
    rs37888631,2
    C,F,A,H,--43524765(+) AAAGAA/TTGGGG 2 -- int122--NS EA NA WA CSA 2116
    rs747231101,2
    C,--43524845(+) AATGCA/GGAACA 2 -- int10--------
    rs581588921,2
    C--43525105(+) GATAG-/ATAG  
            
    GAATG
    2 -- int10--------
    rs1483604201,2
    --43525240(+) TTAGGC/TGTAAA 2 -- int10--------
    rs1883225631,2
    --43525258(+) ATGACA/GTGCCA 2 -- int10--------
    rs1931849741,2
    --43525265(+) GCCACC/TGTATC 2 -- int10--------
    rs1845989451,2
    --43525302(+) GATAAA/TTATAT 2 -- int10--------
    rs575189261,2
    C,--43525375(+) AGTATC/GTGGTT 2 -- int12Minor allele frequency- G:0.00WA CSA 3
    rs1882882091,2
    --43525427(+) AGGCTC/GCATCC 2 -- int10--------
    rs1447226721,2
    --43525463(+) TTTCTA/GTTTTT 2 -- int10--------
    rs1385229391,2
    --43525522(+) AAAACA/GAGACA 2 -- int10--------
    rs1414849261,2
    --43525542(+) TCCCCA/GTAACT 2 -- int10--------
    rs1912324251,2
    --43525554(+) TTCTTC/TCCCTG 2 -- int10--------
    rs1127336311,2
    C,--43525676(+) AGCAAG/ATCCTA 2 -- int11Minor allele frequency- A:0.00CSA 1
    rs1837625061,2
    --43525822(+) TCTTTA/GCTAGT 2 -- int10--------
    rs1884388321,2
    --43525853(+) TTGCCC/TCACTA 2 -- int10--------
    rs1818743021,2
    --43525895(+) TCTTTA/TAAAAA 2 -- int10--------
    rs1857968351,2
    --43526075(+) CCTTAA/CTGGTC 2 -- int10--------
    rs736330161,2
    C,--43526121(+) ATACTG/TGCATG 2 -- int11Minor allele frequency- T:0.00WA 2
    rs1388682431,2
    --43526252(+) GGGGGA/GCGGGG 2 -- int10--------
    rs1820425091,2
    --43526294(+) ATGACG/TAGTCA 2 -- int10--------
    rs1861940691,2
    --43526296(+) GACGAA/GTCAAT 2 -- int10--------
    rs66092501,2
    C,F,A,H,--43526353(+) TGCACG/ATTGTG 2 -- int18Minor allele frequency- A:0.17NA WA CSA 12
    rs1901218671,2
    --43526372(+) CCCTAA/GAACTT 2 -- int10--------
    rs1813575241,2
    --43526377(+) GAACTC/TAAAGT 2 -- int10--------
    rs1850510651,2
    --43526454(+) AAAAGC/GACTCC 2 -- int10--------
    rs65208941,2
    C,F,A,H,--43526548(+) TAATCT/GTAATA 2 -- int121Minor allele frequency- G:0.40NS EA NA WA CSA 1992
    rs1486713781,2
    --43526689(+) GAATAA/GATGAA 2 -- int10--------
    rs1129585971,2
    C,--43526894(+) TACTAA/GTTTTC 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs59068831,2
    C,F,A,H,--43526943(+) TATGCA/CGTACA 2 -- int125Minor allele frequency- N:0.00NS EA NA WA CSA 2605
    rs1898588901,2
    --43527007(+) ACTATA/GACCCA 2 -- int10--------
    rs23108831,2
    C,F,O,H,--43527067(+) TGCAAG/CTATGA 2 -- int17Minor allele frequency- C:0.05NS EA NA WA 512
    rs1453349101,2
    --43527263(+) TAAGAC/GAGCTT 2 -- int10--------
    rs574055441,2
    C,--43527274(+) GCTAGA/GATTGT 2 -- int10--------
    rs736330171,2
    C,--43527465(+) ATATTA/TCTCCA 2 -- int12Minor allele frequency- T:0.00WA CSA 3
    rs1837955661,2
    --43527466(+) TATTTC/TTCCAG 2 -- int10--------
    rs1891549561,2
    --43527474(+) CAGTTA/GTGAGT 2 -- int10--------
    rs1914061241,2
    --43527484(+) TGAGAC/TTGAAC 2 -- int10--------
    rs1502789971,2
    --43527521(+) TTCTTC/TTGTAA 2 -- int10--------
    rs59068931,2
    C,F,A,H,--43527624(+) ATGAAT/CTCTTT 2 -- int119Minor allele frequency- C:0.40NS EA WA NA CSA 1980
    rs1836843291,2
    --43527684(+) TGCACA/GGAAAG 2 -- int10--------
    rs1458034011,2
    --43527753(+) TTAAGA/GTTTTT 2 -- int10--------
    rs1876678861,2
    --43527821(+) TGCTTC/TACTTT 2 -- int10--------
    rs1426775451,2
    C,--43527963(+) CACAAA/CTCTTT 2 -- int10--------
    rs1116814931,2
    C,--43527971(+) TTTCTA/GCTGTA 2 -- int10--------
    rs1842907111,2
    --43528020(+) TAATGA/CTTTTT 2 -- int10--------
    rs1416577071,2
    --43528035(+) AATTTA/CCTGGC 2 -- int10--------
    rs1867016891,2
    --43528286(+) TTGAGC/TTGATG 2 -- int10--------
    rs613454811,2
    C,--43528325(+) CCATCA/GTATTC 2 -- int10--------
    rs59069011,2
    C,A,--43528520(+) AAATAG/CCCTGG 2 -- int14Minor allele frequency- C:0.00NA WA 6
    rs1417751231,2
    --43528636(+) ACTCCA/GGCCTG 2 -- int10--------
    rs1506008851,2
    --43528717(+) TTTTCC/TTTTTG 2 -- int10--------
    rs1396281601,2
    --43529070(+) CAATGA/GACTTG 2 -- int10--------
    rs1427811621,2
    --43529184(+) TACATA/GATCAA 2 -- int10--------
    rs625897111,2
    --43529241(+) ATGAGA/GCTTAG 2 -- int11Minor allele frequency- G:0.00NA 2
    rs1854197971,2
    --43529355(+) TGTTAC/TCTTGT 2 -- int10--------
    rs66108371,2
    C,F,H,--43529604(+) TGTTTT/CTAAAC 2 -- int12Minor allele frequency- C:0.02NS 384
    rs563666531,2
    C--43530460(+) TTTTCA/GTGTGT 2 -- int10--------
    rs59069131,2
    C,F,--43531255(+) GGATGG/CCATTG 2 -- int12Minor allele frequency- C:0.50NA 4
    rs1814821741,2
    --43531291(+) TGGCCA/GGTTTC 2 -- int10--------
    rs1852755021,2
    --43531339(+) TCTTCC/TATTTC 2 -- int10--------
    rs1891012361,2
    --43531364(+) TATTTC/TATTGA 2 -- int10--------
    rs1811462641,2
    --43531721(+) TTCCAA/GCACTA 2 -- int10--------
    rs1855922331,2
    --43532224(+) ATTCTC/TTCTTT 2 -- int10--------
    rs794870211,2
    C,--43532593(+) ATTAGT/CCTTGC 2 -- int12Minor allele frequency- C:0.00NA 4
    rs2008389121,2
    --43532679(+) TTTGT-/GTGTCT 2 -- int10--------
    rs1896151651,2
    --43533026(+) TCCTGA/TGTTCT 2 -- int10--------
    rs1809271741,2
    --43533080(+) CTATTA/CTTTTA 2 -- int10--------
    rs1869846201,2
    --43533096(+) GCTGAA/GGAGAG 2 -- int10--------
    rs1922687471,2
    --43534689(+) CAACTC/TGTCAA 2 -- int10--------
    rs59069141,2
    C,F,A,--43535471(+) AAGACA/GCCATG 2 -- int13Minor allele frequency- G:0.40NA WA 5
    rs1840534031,2
    --43535550(+) AAAGCA/GCAGTA 2 -- int10--------
    rs1860285151,2
    --43535560(+) ATTAGG/TGTGGG 2 -- int10--------
    rs1907442091,2
    --43535588(+) GGTGCC/TGTCTG 2 -- int10--------
    rs803378501,2
    C--43535612(-) TTTCCT/GAGTCA 2 -- int13Minor allele frequency- G:0.25NA CSA 4
    rs792565691,2
    C--43535678(-) GTGCAG/CGAGCC 2 -- int11Minor allele frequency- C:0.50CSA 2
    rs1825725841,2
    --43535691(+) TGCACC/TGCACC 2 -- int10--------
    rs59069151,2
    C,A,--43535692(+) GCACCA/GCACCC 2 -- int14Minor allele frequency- G:0.00NA WA CSA 6
    rs1487302761,2
    --43535713(+) GCCCAC/TTGTCT 2 -- int10--------
    rs1872334341,2
    --43535786(+) GCATCA/GCTCAT 2 -- int10--------
    rs736330181,2
    C,--43535843(+) GCCCTT/CCAGTC 2 -- int12Minor allele frequency- C:0.00WA CSA 3
    rs1828694291,2
    --43535896(+) TCAACA/GAATAT 2 -- int10--------
    rs78826991,2
    C,F,H,--43535927(+) GCCAGG/ATACTA 2 -- int19Minor allele frequency- A:0.01NS EA NA 1192
    rs1513151531,2
    --43535948(+) TGGAGA/GTACAG 2 -- int10--------
    rs2020208901,2
    --43536367(+) GAGGT-/GGAGAAGG 2 -- int10--------
    rs1407176711,2
    --43536386(+) TAAGTA/GTGGAA 2 -- int10--------
    rs1443691371,2
    --43536649(+) CACTGC/GTGGCT 2 -- int10--------
    rs1466111361,2
    C,--43536709(+) ATTGCC/TTTGAA 2 -- int10--------
    rs1877763861,2
    --43537012(+) GTGAAC/TGTAGT 2 -- int10--------
    rs560136161,2
    C,--43537167(+) TAGACT/CTCTTC 2 -- int12Minor allele frequency- C:0.00WA CSA 3
    rs1932457411,2
    --43537656(+) TTTGCA/GTAATA 2 -- int10--------
    rs1856988571,2
    --43537664(+) ATAAAA/CTGTGA 2 -- int10--------
    rs1888631501,2
    --43537951(+) ATAATC/GCAAGA 2 -- int10--------
    rs14651071,2
    C,F,O,A,H,--43538017(+) GCCACA/GGTTAT 2 -- int114Minor allele frequency- N:0.00EA NS NA WA CSA 519
    rs1922002891,2
    --43538099(+) TCCTAA/GCAGCA 2 -- int10--------
    rs14651081,2
    C,F,A,H,--43538209(+) TTAGCA/GCCCAT 2 -- int115Minor allele frequency- G:0.48MN NS EA NA WA CSA 1413
    rs1838663651,2
    --43538388(+) GCTGTC/GATAGG 2 -- int10--------
    rs1885456021,2
    --43538795(+) TGCTAA/CTGAGA 2 -- int10--------
    rs1490227651,2
    --43539225(+) AAACAC/TATTGC 2 -- int10--------
    rs1814437851,2
    --43539294(+) TGTGAA/GCTGAT 2 -- int10--------
    rs1430298261,2
    --43539319(+) ACATAC/TTTAAA 2 -- int10--------
    rs1860375661,2
    --43539351(+) GTAAGA/CGTAGT 2 -- int10--------
    rs1893008601,2
    --43539806(+) ATCCCC/GTCCCA 2 -- int10--------
    rs1822910621,2
    --43539815(+) CATTCC/GCTCTC 2 -- int10--------
    rs1865030141,2
    --43540258(+) ATTTCA/GTCTTT 2 -- int10--------
    rs59069381,2
    C,F,A,H,--43540295(+) CTCCTG/AAGTCT 2 -- int120Minor allele frequency- A:0.40NS EA WA NA CSA 1990
    rs1904993941,2
    --43540339(+) TCTTGC/GTTTCT 2 -- int10--------
    rs1429090831,2
    --43540376(+) TTGTAC/TATTTC 2 -- int10--------
    rs1830668531,2
    --43540453(+) ACACTA/GTAAGT 2 -- int10--------
    rs1855207621,2
    --43540521(+) AAAACA/TAAGAA 2 -- int10--------
    rs1914128441,2
    --43540652(+) ATGCTA/GAAAAA 2 -- int10--------
    rs1123471271,2
    C,--43540776(+) AAAAAC/TGTGAA 2 -- int11Minor allele frequency- T:0.00NA 1
    rs59533851,2
    C,F,A,H,--43540837(+) CGTGTG/ATTTTA 2 -- int120Minor allele frequency- A:0.40NS EA WA NA CSA 1990
    rs1878110521,2
    --43541029(+) GAGAAA/GTATAA 2 -- int10--------
    rs2003253031,2
    --43541051(+) AACTA-/AGAC  
            
    AGAAT
    2 -- int10--------
    rs128436501,2
    --43541128(+) TATATT/ATTTTT 2 -- int12Minor allele frequency- A:0.00NA 4
    rs2016650761,2
    --43541128(+) TATAT-/ATTTTT 2 -- int10--------
    rs1831519861,2
    --43541130(+) TATATA/TTTTTT 2 -- int10--------
    rs48244981,2
    C,A,H,--43541222(+) CCTCCT/CGGGTT 2 -- int15Minor allele frequency- C:0.00NA WA 8
    rs1878282381,2
    --43541287(+) ACCATA/GCCCAG 2 -- int10--------
    rs1919306571,2
    --43541348(+) ATGGTC/TTCGAT 2 -- int10--------
    rs1843112901,2
    --43541535(+) AAAAGC/GGACCA 2 -- int10--------
    rs23108841,2
    C,H,--43541556(+) aagaaA/Ttgcct 2 -- int15Minor allele frequency- T:0.00NS EA NA 404
    rs78922821,2
    C,F,H,--43541620(+) ACTAGA/GAAGGA 2 -- int1 trp36Minor allele frequency- G:0.02NS NA 890
    rs1133931891,2
    C,--43541662(+) AGGGGT/CATGTC 2 -- int11Minor allele frequency- C:0.00CSA 1
    rs1901415261,2
    --43541678(+) GGCATA/CGGAGC 2 -- int10--------
    rs1928784661,2
    --43541730(+) AGCAAC/TGAAAT 2 -- int10--------
    rs126879611,2
    H--43541923(+) cactcC/Tttaag 2 -- int10--------
    rs1497589321,2
    --43541945(+) CATAGC/TCTTTT 2 -- int10--------
    rs1471268721,2
    C,--43541978(+) AGAATA/TACTAT 2 -- int10--------
    rs126879741,2
    H--43542009(+) accacC/Ttcagc 2 -- int10--------
    rs1848829691,2
    --43542023(+) GTGATC/TAGATC 2 -- int10--------
    rs1397387961,2
    --43542214(+) AAGTAG/TGAAGC 2 -- int10--------
    rs1893414741,2
    --43542285(+) TAATCA/GAAATA 2 -- int10--------
    rs1445450261,2
    C,--43542729(+) TTGAAC/TGTTAC 2 -- int10--------
    rs1413737881,2
    --43542966(+) AAGCCA/GTTTGT 2 -- int10--------
    rs587910671,2
    C--43543206(+) CACAG-/ACACACA 2 -- int10--------
    rs1809157691,2
    --43543467(+) GCTACA/GTCGCT 2 -- int10--------
    rs1863022691,2
    --43543489(+) ACTTCA/GGCTTA 2 -- int10--------
    rs1425574111,2
    --43543587(+) AGTAGG/TCAGGG 2 -- int10--------
    rs1509455761,2
    --43543654(+) AGTGGA/GGGAGA 2 -- int10--------
    rs38381951,2
    C--43543822(+) CAAAA-/CAAAA 
            
    ACCCT
    2 -- int10--------
    rs1894802721,2
    --43543825(+) AAAACC/GCTCGC 2 -- int10--------
    rs1407889991,2
    --43543875(+) GAGTAC/TACAAA 2 -- int10--------
    rs2012739911,2
    --43544126(+) CTTTT-/CTTTTT 2 -- int10--------
    rs1820824411,2
    --43544127(+) CTTTTC/TTTTTT 2 -- int10--------
    rs1860612181,2
    --43544274(+) GCACCC/GCCCCC 2 -- int10--------
    rs1917300621,2
    --43544279(+) CCCCCC/GACCAC 2 -- int10--------
    rs1812217381,2
    --43544447(+) TTTGCA/GTGTAG 2 -- int10--------
    rs126880671,2
    C,F,H,--43544506(+) AGTTCT/CCATTC 2 -- int13Minor allele frequency- C:0.25NA 8
    rs1470231141,2
    --43544736(+) AATAAC/TCTACA 2 -- int10--------
    rs1381068111,2
    --43544813(+) CATTTG/TCTTCC 2 -- int10--------
    rs1864670761,2
    --43544967(+) TCAGGA/CCCTAT 2 -- int10--------
    rs1495000051,2
    --43545027(+) CACTAC/TAGAAG 2 -- int10--------
    rs1909073471,2
    --43545084(+) AATCCA/GGATTA 2 -- int10--------
    rs736330191,2
    C,--43545233(+) CTCATT/CTGAGT 2 -- int11Minor allele frequency- C:0.00WA 2
    rs1483171921,2
    --43545347(+) TGTATG/TCCTTT 2 -- int10--------
    rs587952731,2
    C,--43545467(+) TTAAAC/TAGGAG 2 -- int10--------
    rs1822437421,2
    --43545474(+) GGAGCA/GTTAGT 2 -- int10--------
    rs1132036861,2
    C,--43545517(+) CTTTGC/TATAAG 2 -- int11Minor allele frequency- T:0.00CSA 1
    rs1868080901,2
    --43545577(+) ATTACC/TTTGCC 2 -- int10--------
    rs1395458461,2
    --43545633(+) TGTCTA/GTTCAG 2 -- int10--------
    rs1908458451,2
    --43545700(+) ATTAGA/GACTTA 2 -- int10--------
    rs1833979551,2
    --43545708(+) TTAGCA/GTTTAT 2 -- int10--------
    rs20646961,2
    C,A,--43545859(+) CTGGGC/AAACAT 2 -- int16Minor allele frequency- A:0.00NA WA CSA 8
    rs20646971,2
    C,F,A,--43545988(+) GTTGCA/GGTGAG 2 -- int17Minor allele frequency- G:0.20NA WA CSA 10
    rs20646981,2
    C,A,--43546071(+) AAAAAA/GGAAAC 2 -- int1 trp34Minor allele frequency- G:0.00NA WA CSA 5
    rs1929439921,2
    --43546186(+) CTACTA/GTGGAT 2 -- int10--------
    rs1847421241,2
    --43546203(+) GTACCA/GGAATG 2 -- int10--------
    rs2004237251,2
    --43546232(+) GCAAG-/CCTGTT 2 -- int10--------
    rs1880167491,2
    --43546233(+) GCAAGC/GTGTTC 2 -- int10--------
    rs1912402711,2
    --43546245(+) GATGCA/GTCTTC 2 -- int10--------
    rs128395501,2
    H--43546460(+) CAGTGT/GTACCG 2 -- int14Minor allele frequency- G:0.00NS EA 410
    rs1137789231,2
    C,--43546627(+) AACTCT/CCAGGA 2 -- int11Minor allele frequency- C:0.00CSA 1
    rs70510421,2
    C,F,H,--43546669(+) ATTTAT/CTGGAG 2 -- int16Minor allele frequency- C:0.04NS EA WA CSA 383
    rs1837700841,2
    --43546689(+) CAGTTC/TTGTTC 2 -- int10--------
    rs1884452551,2
    --43547048(+) GTCATA/GCTCAA 2 -- int10--------
    rs59058091,2
    C,F,H,--43547230(+) CTGCCC/GCCTAC 2 -- int18Minor allele frequency- G:0.15NA WA CSA 13
    rs1818830131,2
    --43547231(+) TGCCGA/CCTACA 2 -- int10--------
    rs59069571,2
    C,F,A,H,--43547310(+) TGCTCG/AAGACC 2 -- int113Minor allele frequency- A:0.43NS EA NA WA CSA 432
    rs1856717861,2
    --43547312(+) CTCAAG/TACCTT 2 -- int10--------
    rs1421299281,2
    --43547382(+) CTTTAC/TGTGAC 2 -- int10--------
    rs1901381901,2
    --43547388(+) GTGACC/TTGCTC 2 -- int10--------
    rs1817946831,2
    --43547578(+) GGCTGC/GAGTGC 2 -- int10--------
    rs1863529111,2
    --43547592(+) GGGACA/GATCTC 2 -- int10--------
    rs1477714871,2
    --43547607(+) CACTGC/TAGCCA 2 -- int10--------
    rs1411706081,2
    --43547796(+) CATCAC/GTGCAT 2 -- int10--------
    rs1912099781,2
    --43547898(+) TTTCTG/TCTTGA 2 -- int10--------
    rs1813175871,2
    --43547954(+) GTCCAC/TTAGAA 2 -- int10--------
    rs1125921731,2
    C,--43548362(+) TCACTT/GTGTTG 2 -- int11Minor allele frequency- G:0.00NA 1
    rs1476284971,2
    --43548473(+) CAGGCA/GCTGCC 2 -- int10--------
    rs1850102191,2
    --43548777(+) GTCTAA/GAGTTT 2 -- int10--------
    rs59069711,2
    C,--43548788(+) ATCAAT/CATACT 2 -- int17Minor allele frequency- C:0.00WA NA CSA 11
    rs1898170361,2
    --43549285(+) TTTAGA/GAGCTC 2 -- int10--------
    rs1831371231,2
    --43549462(+) TACCTC/GCTCAA 2 -- int10--------
    rs1888339641,2
    --43549613(+) TTGCTA/GGCAGT 2 -- int10--------
    rs2016027361,2
    --43549993(+) TAAGC-/TTTTTT 2 -- int10--------
    rs66108421,2
    H--43550026(+) acttaG/Cagctg 2 -- int14Minor allele frequency- C:0.00NS EA 420
    rs1916647061,2
    --43550115(+) GAAAAC/GAAAAA 2 -- int10--------
    rs1834770811,2
    --43550237(+) ACAAAA/GAGGAT 2 -- int10--------
    rs1888193911,2
    --43550342(+) AATACA/GAGATC 2 -- int10--------
    rs1117170841,2
    C,--43550349(+) GATCAA/GAGCCA 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs285937001,2
    --43550628(+) AAAAAA/TAAAAA 2 -- int1 trp30--------
    rs1842742861,2
    --43550650(+) AAGATA/GAAAAT 2 -- int10--------
    rs1130356391,2
    --43550663(+) AGATAC/TAATTA 2 -- int11Minor allele frequency- T:0.00CSA 1
    rs1386078811,2
    --43550784(+) AGTTAA/TCAGTG 2 -- int10--------
    rs1914829051,2
    --43550816(+) GATGGA/GTAGTG 2 -- int10--------
    rs1855653371,2
    --43551115(+) ATCCTC/TCAACA 2 -- int10--------
    rs1903869121,2
    --43551245(+) ACTGTA/GTAGAC 2 -- int10--------
    rs59069731,2
    C,F,A--43551287(+) CACACA/GCACGC 2 -- int14Minor allele frequency- G:0.33NA WA 6
    rs2015833701,2
    C--43551290(-) TGTGCA/GTGCGT 2 -- int10--------
    rs59069741,2
    C,F,A,H,--43551321(+) GCCAGT/CGAGCT 2 -- int117Minor allele frequency- C:0.47NS EA NA WA CSA 663
    rs30273921,2
    C,F,H,--43551400(+) GGGGAG/ATTGCT 2 -- int15Minor allele frequency- A:0.06NS EA WA 422
    rs754263711,2
    C,--43551427(+) CCGAAG/-GCTGA 2 -- int11Minor allele frequency- -:0.00CSA 2
    rs1382023911,2
    --43551499(+) GTGTAC/TTGATT 2 -- int10--------
    rs1816225541,2
    --43551560(+) AGGACA/CAAGGG 2 -- int10--------
    rs1427215151,2
    --43551638(+) ATGGTA/GTAAAG 2 -- int10--------
    rs1851693181,2
    --43551660(+) TGTGAG/TAGTCC 2 -- int10--------
    rs1890565951,2
    --43551676(+) TGTGGA/GCAGAA 2 -- int10--------
    rs1811482641,2
    --43551677(+) GTGGGA/CAGAAG 2 -- int10--------
    rs1855402571,2
    --43551972(+) ACTGTA/GTTTAT 2 -- int10--------
    rs1880465401,2
    --43552087(+) TGACGC/GATTCT 2 -- int10--------
    rs1460666861,2
    C,--43552477(+) TTTTAA/C/G/
            
    AAGAC
    2 -- int10--------
    rs774829391,2
    C--43552536(-) CATTCA/C/TGCAAA 2 -- spa11CSA 1
    rs1808557151,2
    C,--43552555(+) GATTAC/TGTAGA 3 Y ut51 syn10--------
    rs1487884031,2
    C,--43552691(+) CTTTTA/CACCCA 2 -- int10--------
    rs413036971,2
    C,--43552773(+) ATTGTA/GAAAGT 2 -- int12Minor allele frequency- G:0.06NA 33
    rs1508722841,2
    C,--43552815(+) TCTTTC/TCTTGT 2 -- int10--------
    rs1872222281,2
    --43552826(+) TTTCTG/TTTTTC 2 -- int10--------
    rs1919364051,2
    --43553152(+) AGCCTC/TTGAAC 2 -- int10--------
    rs1842362131,2
    --43553172(+) ATCCTC/TATTCT 2 -- int10--------
    rs9095251,2
    C,F,O,A,H,--43553202(-) GAAATA/GAAGCA 2 -- int134Minor allele frequency- N:0.00EA NA NS WA CSA 3032
    rs1866548181,2
    --43553385(+) AAATCA/GAAGTT 2 -- int10--------
    rs1496909451,2
    --43553527(+) CACCTC/TGGGCA 2 -- int10--------
    rs30273951,2
    C,H,--43553528(+) ACCTCG/CGGCAA 2 -- int14Minor allele frequency- C:0.00NS EA 420
    rs1395636861,2
    --43553546(+) GGGTCC/TGGAGG 2 -- int10--------
    rs1907685381,2
    --43553678(+) GGGATA/GGTCTG 2 -- int10--------
    rs1825449441,2
    --43553764(+) GAAAAC/TCAGTA 2 -- int10--------
    rs1872460311,2
    --43554013(+) TTTAAC/TATAGG 2 -- int10--------
    rs1912320471,2
    --43554260(+) GCATTA/GTCATC 2 -- int10--------
    rs30273961,2
    C,F,H,--43554672(+) AGCCAT/CGCCCA 2 -- int121Minor allele frequency- C:0.42NS EA NA WA CSA 1988
    rs1826009571,2
    --43555316(+) GTGGTC/TCTGCT 2 -- int10--------
    rs65208971,2
    C,F,A,H,--43555564(+) TTTCAC/AAAAAA 2 -- int18Minor allele frequency- A:0.02NS EA NA 896
    rs286190591,2
    F--43555719(+) TGCCTG/ATAATC 2 -- int11Minor allele frequency- A:0.50NA 4
    rs1475659701,2
    --43555837(+) CGGGCA/GTGCTG 2 -- int10--------
    rs22389681,2
    C,F,--43555863(+) CCCAGA/CTACCA 2 -- int16Minor allele frequency- C:0.33NA WA 12
    rs1930639521,2
    --43555970(+) AGAGCA/GAGACT 2 -- int10--------
    rs1431987331,2
    --43556200(+) ACAGCC/TGCTGT 2 -- int10--------
    rs59058221,2
    C,F,--43556275(+) TCCCAG/TTATGT 2 -- int19Minor allele frequency- T:0.25NA WA CSA 16
    rs1858338481,2
    --43556540(+) GGCAGC/TTCTCT 2 -- int10--------
    rs1888119081,2
    --43556568(+) GTCCAC/TCATTG 2 -- int10--------
    rs1921923871,2