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MAOA Gene

protein-coding   GIFtS: 72
GCID: GC0XP043515

Monoamine Oxidase A

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Monoamine Oxidase A1 2
Monoamine Oxidase Type A2 3
MAO-A2 3
EC 1.4.3.43 8
Amine Oxidase [Flavin-Containing] A2
EC 1.4.38

External Ids:    HGNC: 68331   Entrez Gene: 41282   Ensembl: ENSG000001892217   OMIM: 3098505   UniProtKB: P213973   

Export aliases for MAOA gene to outside databases

Previous GC identifers: GC0XP041545 GC0XP041794 GC0XP042360 GC0XP042636 GC0XP043271 GC0XP043400 GC0XP041246


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAOA Gene:
This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the
oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results
in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including
antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
(provided by RefSeq, Jul 2012)

GeneCards Summary for MAOA Gene:
MAOA (monoamine oxidase A) is a protein-coding gene. Diseases associated with MAOA include antisocial personality disorder, and avoidant personality disorder. GO annotations related to this gene include primary amine oxidase activity. An important paralog of this gene is MAOB.

UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397
Function: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the
metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA
preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine

summary for MAOA Gene:
Monoamine Oxidases (MAO) catalyze the oxidation of monoamines such as dopamine, serotonin and adrenalin.
They are found bound to the outer membrane of mitochondria in most cell types in the body. Two subtypes of
monoamine oxidase have been identified: MAO-A and MAO-B. Both are found in neurons and astroglia, with MAO-A
also found in the liver, gastrointestinal tract and placenta and MAO-B in blood platelets. Abnormal
regulation of MAOs in the body has been associated with depression, substance abuse, attention deficit
disorder, and irregular sexual maturation.

Gene Wiki entry for MAOA (Monoamine oxidase A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_079573.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAOA gene promoter:
         MEF-2A   c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAOA promoter sequence
   Search Chromatin IP Primers for MAOA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAOA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.3   Ensembl cytogenetic band:  Xp11.3   HGNC cytogenetic band: Xp11.4-p11.3

MAOA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAOA gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP043515:  view genomic region     (about GC identifiers)

Start:
43,515,409 bp from pter      End:
43,606,068 bp from pter
Size:
90,660 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397 (See protein sequence)
Recommended Name: Amine oxidase [flavin-containing] A  
Size: 527 amino acids; 59682 Da
Cofactor: FAD
Subunit: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a
covalently bound flavin. Enzymatically active as monomer
Mass spectrometry: Mass=60512; Mass_error=6; Method=Electrospray; Range=1-527; Source=PubMed:11812236;
5 PDB 3D structures from and Proteopedia for MAOA:
1H8Q (3D)        2BXR (3D)        2BXS (3D)        2Z5X (3D)        2Z5Y (3D)    
Secondary accessions: B4DF46 Q16426
Alternative splicing: 2 isoforms:  P21397-1   P21397-2   

Explore the universe of human proteins at neXtProt for MAOA: NX_P21397

Explore proteomics data for MAOA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys469
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAOA (P21397) (see all 22)
     RQPVGRI  DYNNLWR  ERNLPSV  FPPVWNP 


    See MAOA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000231.1  NP_001257387.1  

    ENSEMBL proteins: 
     ENSP00000340684   ENSP00000440846  
    Reactome Protein details: P21397

    MAOA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MAOA
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MAOA
    GenScript Custom Purified and Recombinant Proteins Services for MAOA
    Novus Biologicals MAOA Protein
    Novus Biologicals MAOA Lysates
    Sino Biological Recombinant Protein for MAOA
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAOA

    MAOA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAOA
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MAOA
    OriGene Custom Antibody Services for MAOA
    Novus Biologicals MAOA Antibodies
    Abcam antibodies for MAOA (P21397, P27338)
    Cloud-Clone Corp. Antibodies for MAOA
    ThermoFisher Antibodies for MAOA
    LSBio Antibodies in human, mouse, rat for MAOA

    MAOA Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MAOA
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAOA
    Cloud-Clone Corp. CLIAs for MAOA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001613 Flavin_amine_oxidase
     IPR002937 Amino_oxidase

    Graphical View of Domain Structure for InterPro Entry P21397

    ProtoNet protein and cluster: P21397

    1 Blocks protein domain: IPB001613 Flavin-containing amine oxidase signature

    UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397
    Similarity: Belongs to the flavin monoamine oxidase family


    MAOA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AOFA_HUMAN, P21397
    Function: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the
    metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA
    preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine
    Catalytic activity: RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2)

         Genatlas biochemistry entry for MAOA:
    monoamine oxidase A,overexpressed in female panic disorders

         Enzyme Numbers (IUBMB): EC 1.4.3.41 2 EC 1.4.32

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008131primary amine oxidase activity TAS--
    GO:0016491oxidoreductase activity ----
    GO:0050660flavin adenine dinucleotide binding ----
         
    MAOA for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MAOA:
     Decreased viability 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Maoa):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  nervous system 

    MAOA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Maoatm1Shih for MAOA

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAOA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAOA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAOA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAOA

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAOA:
    hsa-mir-22-3p (MIRT005902)

    Block miRNA regulation of human, mouse, rat MAOA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAOA (see all 13):
    hsa-miR-3163 hsa-miR-495 hsa-miR-767-3p hsa-miR-7-2* hsa-miR-1324 hsa-miR-3065-5p hsa-miR-624* hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidMAOA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAOA
    Predesigned siRNA for gene silencing in human, mouse, rat MAOA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAOA

    Clone
    Products:
         
    OriGene clones in human, mouse for MAOA (see all 7)
    OriGene ORF clones in mouse, rat for MAOA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAOA (NM_000240)
    Sino Biological Human cDNA Clone for MAOA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAOA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAOA

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MAOA 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAOA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AOFA_HUMAN, P21397: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    extracellular2
    nucleus2
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005741mitochondrial outer membrane TAS--
    GO:0016021integral component of membrane IEA--

    MAOA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAOA About   (see all 25)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Serotonin clearance from the synaptic cleft
    Enzymatic degradation of dopamine by COMT0.33
    Enzymatic degradation of Dopamine by monoamine oxidase0.00
    Serotonin clearance from the synaptic cleft0.33
    Metabolism of serotonin0.00
    melatonin degradation II0.00
    2Phenylalanine metabolism
    Phenylalanine metabolism0.36
    noradrenaline and adrenaline degradation0.31
    Tyrosine metabolism0.36
    phenylalanine degradation IV0.00
    phenylalanine utilization0.33
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neurotransmitter Clearance In The Synaptic Cleft0.00
    Neuronal System0.68
    Dopamine clearance from the synaptic cleft0.00
    5tryptophan utilization II
    tryptophan utilization II0.71
    superpathway of melatonin degradation0.00
    tryptophan utilization I0.71
    serotonin degradation0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for MAOA
        Tyrosine metabolism p.1 (dopamine)

    Selected BioSystems Pathways for MAOA (see all 15)
        Biogenic Amine Synthesis
    SIDS Susceptibility Pathways
    Oxidative Stress
    dopamine degradation
    serotonin degradation


    5 Reactome Pathways for MAOA
        Enzymatic degradation of dopamine by COMT
    Metabolism of serotonin
    Enzymatic degradation of Dopamine by monoamine oxidase
    Norepinephrine Neurotransmitter Release Cycle
    Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2

    1 PharmGKB Pathway for MAOA
        Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for MAOA) (see all 13):
        Glycine, serine and threonine metabolism
    Arginine and proline metabolism
    Histidine metabolism
    Tyrosine metabolism
    Phenylalanine metabolism


    MAOA for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAOA: 
              Amino Acid Metabolism II in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAOA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAOA (P213972, 3 ENSP000003406844) via UniProtKB, MINT, STRING, and/or I2D (see all 94)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    NDRG1Q925973, ENSP000003199774I2D: score=3 STRING: ENSP00000319977
    ATP6V1B2P212812, ENSP000002763904MINT-4054731 STRING: ENSP00000276390
    YWHABP319463I2D: score=1 
    A2MP010232MINT-4054731
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006576cellular biogenic amine metabolic process TAS8211186
    GO:0006805xenobiotic metabolic process TAS--
    GO:0007268synaptic transmission TAS--
    GO:0007269neurotransmitter secretion TAS--
    GO:0007610behavior ----

    MAOA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MAOA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Rasagiline mesylate Selective, irreversible MAO-B inhibitor [161735-79-1]
    (R)-(-)-Deprenyl hydrochlorideMAO-B inhibitor[14611-52-0]
    MoclobemideReversible MAO-A inhibitor[71320-77-9]
    Lazabemide hydrochlorideSelective MAO-B inhibitor[103878-83-7]
    Bifemelane hydrochlorideMAO-A and MAO-B inhibitor[90293-01-9]

    Selected HMDB Compounds for MAOA (see all 43)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Methylhistamine1-Methyl-1H-imidazole-4-ethanamine (see all 21)501-75-7--
    1-Phenylethylaminea-phenylethylamine (see all 17)98-84-0--
    3,4-Dihydroxymandelaldehyde3,4-Dihydroxyphenylglycolaldehyde (see all 4)13023-73-9--
    3,4-DihydroxyphenylacetaldehydeProtocatechuatealdehyde (see all 2)5707-55-1--
    3-Methoxy-4-hydroxyphenylglycolaldehydea,4-dihydroxy-3-methoxy-Benzeneacetaldehyde (see all 4)17592-23-3--
    3-Methoxytyramine3-Methoxy-4-hydroxyphenylethyl amine (see all 7)554-52-9--
    4,6-Dihydroxyquinoline4,6-Quinolinediol (see all 2)3517-61-1--
    5-Hydroxyindoleacetaldehyde(5-hydroxy-1H-indol-3-yl)acetaldehyde (see all 6)1892-21-3--
    5-Hydroxykynurenamine5-Hydroxykynuramine (see all 3)708-23-6--
    5-Methoxytryptamine2-(5-Methoxy-1H-indol-3-yl)ethanamine (see all 10)608-07-1--

    Selected DrugBank Compounds for MAOA (see all 37)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Tranylcypromine-- 155-09-9targetinhibitor12504917 8749840 15351283 15276688 10548268 14574774 11752352 20655983 16495723 10027835 15049511 10494892 9829163
    Phenelzine-- 51-71-8targetantagonist17768678 17912044 14574774 11752352 7092487 19201819 16370964 18700056 9829163
    enzymesubstrate17768678 17912044 14574774 11752352 7092487 19201819 16370964 18700056 9829163 17768678
    PargylineBenzyl-methyl-2-propinylamin (see all 12)555-57-7targetinhibitor19300583 17823646 9564606 477738 16641841 17715422
    Phentermine-- 122-09-8targetantagonist11911838 11673765 10799660 10231134
    enzymeinhibitor11911838 11673765 10799660 10231134 11911838 10799660
    Moclobemide4-Chlor-N-(2-morpholinoethyl)benzamid (see all 11)71320-77-9targetinhibitor1705137 8875133 11752352
    enzymeinhibitor1705137 8875133 11752352 11752352
    SelegilineL-Deprenalin (see all 4)14611-51-9targetinhibitor19300583 17823646 16641841 17715422
    Almotriptan-- 181183-52-8enzymesubstrate12353056 12642466 15762767
    DopamineDopamin (see all 6)51-61-6enzymesubstrate15817751 18652859 20869994
    Flavin-Adenine Dinucleotide-- 146-14-5target--17139284 17016423 10592235
    FurazolidoneNitrofurazolidone (see all 3)67-45-8enzymeinhibitor12623758 2032659 10543364

    Selected Novoseek inferred chemical compound relationships for MAOA gene (see all 133)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    maoa 98.5 1084 17692293 (10), 19224413 (8), 11927135 (8), 15936529 (8) (see all 99)
    moclobemide 94.9 153 1546132 (5), 8612391 (3), 9663810 (3), 9174681 (3) (see all 99)
    clorgyline 91.8 98 1741773 (4), 9564606 (3), 1893487 (3), 8243537 (2) (see all 54)
    brofaromine 90.8 33 8430214 (4), 1967018 (2), 8313400 (2), 8313393 (2) (see all 22)
    befloxatone 90.4 36 8613928 (8), 12729662 (3), 7665725 (2), 9728902 (2) (see all 15)
    kynuramine 89.7 14 20504539 (1), 8990278 (1), 16139309 (1), 8443155 (1) (see all 12)
    toloxatone 88.5 10 1546145 (2), 1705137 (2), 1424410 (2), 8713690 (1) (see all 6)
    tyramine 85.5 68 17561096 (4), 8255365 (3), 8695909 (2), 7665725 (2) (see all 37)
    pirlindole 83.5 16 8953568 (3), 9564636 (2), 12781338 (2), 9272198 (2) (see all 7)
    1-phenylcyclopropylamine 81.4 3 15755651 (1), 15848762 (1)



    MAOA for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAOA gene (2 alternative transcripts): 
    NM_000240.3  NM_001270458.1  

    Unigene Cluster for MAOA:

    Monoamine oxidase A
    Hs.183109  [show with all ESTs]
    Unigene Representative Sequence: NM_001270458
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338702(uc004dfy.3 uc011mkw.2) ENST00000497485 ENST00000490604
    ENST00000542639
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MAOA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAOA (see all 13):
    hsa-miR-3163 hsa-miR-495 hsa-miR-767-3p hsa-miR-7-2* hsa-miR-1324 hsa-miR-3065-5p hsa-miR-624* hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidMAOA 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MAOA
    Predesigned siRNA for gene silencing in human, mouse, rat MAOA
    Clone
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    OriGene clones in human, mouse for MAOA (see all 7)
    OriGene ORF clones in mouse, rat for MAOA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAOA (NM_000240)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAOA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAOA
    Primer
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    OriGene qPCR primer pairs and template standards for MAOA
    OriGene qSTAR qPCR primer pairs in human, mouse for MAOA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAOA
      QuantiTect SYBR Green Assays in human, mouse, rat MAOA
      QuantiFast Probe-based Assays in human, mouse, rat MAOA

    Additional mRNA sequence: 

    AK123241.1 AK223499.1 AK291769.1 AK293926.1 BC008064.2 BC044787.1 BT006651.1 M68840.1 
    X17192.1 

    11 DOTS entries:

    DT.95120451  DT.87015236  DT.101981844  DT.100025285  DT.100825058  DT.121278195  DT.100708824  DT.121278204 
    DT.95120454  DT.100718004  DT.70102839 

    Selected AceView cDNA sequences (see all 267):

    AI674356 AW511315 BU684121 R97085 CA444528 AA865791 BM923944 AA995668 
    F02245 AI076531 BQ717463 N29331 AW873998 BQ716421 AI890731 NM_000240 
    AW627528 BG534382 BF448960 N30236 H82430 CK818786 R86250 AI335934 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    MAOA expression in normal human tissues (normalized intensities)      MAOA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGAAGTTT
    MAOA Expression
    About this image


    MAOA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             White adipocyte-like cells
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
             Alveolar type II cells
    MAOA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAOA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.183109

    UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397
    Tissue specificity: Heart, liver, duodenum, blood vessels and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAOA: 
              Amino Acid Metabolism II in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MAOA
    OriGene qSTAR qPCR primer pairs in human, mouse for MAOA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAOA
    QuantiTect SYBR Green Assays in human, mouse, rat MAOA
    QuantiFast Probe-based Assays in human, mouse, rat MAOA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAOA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for MAOA gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Maoa1 , 5 monoamine oxidase A1, 5 85.19(n)1
    88.12(a)1
      X (11.78 cM)5
    171611  NM_173740.31  NP_776101.31 
     166196985 
    chicken
    (Gallus gallus)
    Aves MAOA6
    Gallus gallus monoamine oxidase A (MAOA), nuclear ...
    72(a)
    1 ↔ 1
    1(110613430-110658911)
    lizard
    (Anolis carolinensis)
    Reptilia MAOA6
    monoamine oxidase A
    72(a)
    1 ↔ 1
    3(135069134-135125415)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004951981 amine oxidase [flavin-containing] A-like 68.62(n)
    70.76(a)
      100495198  XM_002932798.2  XP_002932844.2 
    zebrafish
    (Danio rerio)
    Actinopterygii mao6
    monoamine oxidase
    69(a)
    1 → many
    9(34618751-34683759) ENSDARG00000023712


    ENSEMBL Gene Tree for MAOA (if available)
    TreeFam Gene Tree for MAOA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for MAOA gene
    MAOB2  
    1 SIMAP similar gene for MAOA using alignment to 7 protein entries:     AOFA_HUMAN (see all proteins):
    MAOB

    MAOA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Polymorphic Variants from UniProtKB/Swiss-Prot
    AOFA_HUMAN, P21397: A polymorphism 1.2 kb upstream of the MAOA coding sequences consists of a 30-bp repeated sequence
    present in 3, 3.5, 4, or 5 copies. The polymorphism affect transcriptional activity of the MAOA gene promoter.
    Alleles with 3.5 or 4 copies of the repeat sequence are transcribed 2 to 10 times more efficiently than those
    with 3 or 5 copies of the repeat


    Selected SNPs for MAOA (see all 1109)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365454
    A breast cancer sample4--see VAR_0365452 D E mis40--------
    rs725546321,2
    Cpathogenic143591031(+) TAATTC/TAGCGG 4 Q * stg10--------
    rs1923952121,2
    --43512260(+) AGGATC/TGAGGC 2 -- us2k10--------
    rs66518041,2
    C,F--43512290(+) caGTCA/GGCCTC 2 -- us2k12Minor allele frequency- G:0.00WA CSA 3
    rs66518051,2
    C,F--43512293(+) TCGGCT/CTCAGC 2 -- us2k12Minor allele frequency- C:0.00WA CSA 3
    rs48246571,2
    C,F,A,H--43512302(+) GCAGCC/GTTGTC 2 -- us2k110Minor allele frequency- G:0.32NA WA CSA 19
    rs1904159451,2
    --43512369(+) TTTTTC/TCTACC 2 -- us2k10--------
    rs1118209341,2
    C,F--43512512(+) ACATTC/TGTCAG 2 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs1816096531,2
    --43512744(+) GATTTC/TTTCAT 2 -- us2k10--------
    rs1843172791,2
    --43512882(+) CATATG/TTCTTT 2 -- us2k10--------
    rs1890954131,2
    --43512904(+) AACAAA/GATGTT 2 -- us2k10--------
    rs736330151,2
    C,F--43512980(+) TCCTCC/GAGTTC 2 -- us2k12Minor allele frequency- G:0.00WA CSA 3
    rs1811407181,2
    --43513085(+) ATGGCA/GCGATC 2 -- us2k10--------
    rs1855863721,2
    --43513086(+) TGGCGC/TGATCT 2 -- us2k10--------
    rs1909237721,2
    --43513162(+) GGGATC/TACAGG 2 -- us2k10--------
    rs1809320931,2
    C--43513274(+) CGCCTC/TGGCCT 2 -- us2k10--------
    rs1872237841,2
    --43513286(+) CCAAAA/GTGCCG 2 -- us2k10--------
    rs1467199001,2
    C--43513351(+) TCCAGC/TAATGA 2 -- us2k10--------
    rs1919814541,2
    --43513396(+) AAAAAG/TTGGAA 2 -- us2k10--------
    rs1842436081,2
    --43513578(+) GATAGA/GTGAGT 2 -- us2k10--------
    rs574113561,2
    C,F--43513808(+) CCCGCT/CCCTCC 2 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1874973111,2
    --43514041(+) CTACAC/TCCACG 2 -- us2k10--------
    rs59532101,2
    C,F,H--43514046(+) CCCACA/GTCTAC 2 -- us2k119Minor allele frequency- G:0.40NS EA NA WA CSA 1991
    rs1907812211,2
    --43514057(+) TCCCCC/GACTCT 2 -- us2k10--------
    rs1997606051,2
    --43514419(+) CACCG-/GCACC 
     AGTACCC
    GCACC
    2 -- cds10--------
    rs1825643991,2
    --43514856(+) CGCCCG/TTAAAC 2 -- ut510--------
    rs174360541,2
    C--43515013(+) ACCCAA/GTGACC 2 -- ut512Minor allele frequency- G:0.00NA 4
    rs1872234331,2
    --43515345(+) ACAAGA/GGTCCG 2 -- ut510--------
    rs1925494441,2
    --43515516(+) GGAGTC/TGATAG 2 -- ut510--------
    rs1843517161,2
    --43515719(+) GGGGAA/GCCTAC 2 -- int10--------
    rs1432219851,2
    C--43515952(+) TCAGTC/TCTCAA 2 -- int10--------
    rs1880481671,2
    --43516091(+) ATTTAA/GGACCT 2 -- int10--------
    rs1930801611,2
    --43516191(+) ATTGAG/TGGAGC 2 -- int10--------
    rs1848197021,2
    --43516268(+) AGGTAA/GACTCC 2 -- int10--------
    rs105604021,2
    C--43516333(+) ATTCC-/TGtgtgt 2 -- int10--------
    rs30300711,2
    C--43516522(+) TATAT-/ATA   
      T
    /TATA
    GAACT
    2 -- int10--------
    rs1888504371,2
    --43516590(+) GGACAC/TTTATT 2 -- int10--------
    rs1390515571,2
    C--43516639(+) CCCTGC/TTGTAT 2 -- int10--------
    rs1418408491,2
    --43517259(+) TTTATG/TTATGT 2 -- int10--------
    rs37888621,2
    C,F,A,H--43517364(+) AAGCAA/GTATGG 2 -- int117Minor allele frequency- G:0.56EA NS NA WA CSA 636
    rs1921883801,2
    --43517575(+) CTGCTC/TTTCCT 2 -- int10--------
    rs1838579001,2
    --43517790(+) TGTAGA/GTCCCA 2 -- int10--------
    rs1896143421,2
    --43517838(+) AATTTA/TTTTCC 2 -- int10--------
    rs1806879321,2
    --43517842(+) TATTTC/TCATTT 2 -- int10--------
    rs1859514571,2
    --43517844(+) TTTCCA/TTTTGG 2 -- int10--------
    rs125566941,2
    C,F,H--43518067(+) TGGCTC/TGTGTT 2 -- int14Minor allele frequency- T:0.00NS EA 416
    rs1818874521,2
    --43518105(+) ATGAGA/CGGGTG 2 -- int10--------
    rs59057021,2
    C,F,A,H--43518188(+) ATGAAT/GTACTT 2 -- int119Minor allele frequency- G:0.48NS EA NA WA CSA 1967
    rs1864980121,2
    --43518192(+) ATTACA/TTAATA 2 -- int10--------
    rs1419240411,2
    --43518337(+) AGCACC/GCAGAA 2 -- int10--------
    rs1506678771,2
    C--43518457(+) CATTAG/TAAAAC 2 -- int10--------
    rs1379692801,2
    C--43518458(+) ATTATA/GAAACA 2 -- int10--------
    rs1904910591,2
    --43518478(+) CTATGC/TCTTAC 2 -- int10--------
    rs1830615721,2
    --43518564(+) ATAACC/GCTGCT 2 -- int10--------
    rs1862983981,2
    --43518982(+) CAATCC/TAGCTT 2 -- int10--------
    rs65208931,2
    C,H--43519176(+) TAAAAA/GTATTT 2 -- int17Minor allele frequency- G:0.01NS WA NA CSA 188
    rs1834254301,2
    --43519494(+) AAAAGC/TTCTTG 2 -- int10--------
    rs1875476321,2
    --43519675(+) CAGCCC/TCCCAA 2 -- int10--------
    rs1927702211,2
    --43519680(+) TCCCAA/GACACC 2 -- int10--------
    rs1494886741,2
    C--43519688(+) ACCTCC/TCTATC 2 -- int10--------
    rs1831471771,2
    C--43519696(+) ATCCCA/GCCCCC 2 -- int10--------
    rs1459358241,2
    --43519786(+) CACTAC/TGTTTA 2 -- int10--------
    rs1878185681,2
    --43519997(+) ATTTCA/GTGATT 2 -- int10--------
    rs1919227891,2
    --43520082(+) AATGAC/TAGAAA 2 -- int10--------
    rs1843494321,2
    --43520211(+) CCTTCA/GTGAGT 2 -- int10--------
    rs1398286541,2
    --43520335(+) TGTAGC/TTTTGA 2 -- int10--------
    rs1904295511,2
    --43520343(+) TGAACA/GCATTT 2 -- int10--------
    rs59067291,2
    C,F,A,H--43520371(+) GGTCTC/GTCAAA 2 -- int110Minor allele frequency- G:0.49NS EA NA WA CSA 427
    rs1926839861,2
    --43520526(+) AAGGTA/TCTTCT 2 -- int10--------
    rs1850331671,2
    --43520650(+) TTTGAA/GTATGA 2 -- int10--------
    rs171466601,2
    C,F,H--43520782(+) GCCAGA/TTATGA 2 -- int110Minor allele frequency- T:0.04NA NS EA WA CSA 435
    rs1890965491,2
    --43520942(+) TTAGCA/GAGCGC 2 -- int10--------
    rs1809214011,2
    --43521044(+) GTCACA/GTAGAA 2 -- int10--------
    rs1862966331,2
    --43521090(+) GAACTA/CCTCTC 2 -- int10--------
    rs1129587851,2
    C--43521312(+) TAAAAG/ATTATT 2 -- int11Minor allele frequency- A:0.00CSA 1
    rs1894728001,2
    --43521337(+) TTAGGA/CATTTT 2 -- int10--------
    rs66108341,2
    C--43521681(+) ATTTTA/GGCATT 2 -- int10--------
    rs1509894901,2
    --43521995(+) TAGACA/CCCCGA 2 -- int10--------
    rs78802301,2
    C,F,H--43522021(+) GAATAT/CACTTG 2 -- int18Minor allele frequency- C:0.18NS NA WA CSA 893
    rs1820753371,2
    --43522106(+) CAAAAC/TATTTT 2 -- int10--------
    rs1447560341,2
    C--43522374(+) AGATCC/TGTCTC 2 -- int10--------
    rs1867118271,2
    --43522398(+) CTTGGA/TCCCTC 2 -- int10--------
    rs1478705041,2
    --43522409(+) CTCAAC/TGTTTT 2 -- int10--------
    rs1920140931,2
    --43522423(+) CTTCTA/GTGCTT 2 -- int10--------
    rs1828976761,2
    --43522616(+) TAATTA/GATTGA 2 -- int10--------
    rs1131868451,2
    C,F--43522717(+) GGCCTA/GTAAGA 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs1866510871,2
    --43522821(+) AAATAC/TTGACT 2 -- int10--------
    rs1895823621,2
    C--43522969(+) ATTTAC/TATATT 2 -- int10--------
    rs732111891,2
    C--43523226(+) TTTTAC/TGCATA 2 -- int10--------
    rs1822337081,2
    --43523427(+) CATTCA/CGGCTG 2 -- int10--------
    rs1875521691,2
    --43523597(+) TTTAAA/TGTATC 2 -- int10--------
    rs1908840111,2
    --43523845(+) TGAAGA/TTGACC 2 -- int10--------
    rs1834325131,2
    --43523941(+) TTCATC/TCATTC 2 -- int10--------
    rs1477333211,2
    --43524316(+) AACTAA/GGCAGG 2 -- int10--------
    rs37888631,2
    C,F,A,H--43524765(+) AAAGAA/TTGGGG 2 -- int122--NS EA NA WA CSA 2116
    rs747231101,2
    C--43524845(+) AATGCA/GGAACA 2 -- int10--------
    rs581588921,2
    C--43525061(+) GATAG-/ATAG  
            
    GAATG
    2 -- int10--------
    rs1483604201,2
    --43525240(+) TTAGGC/TGTAAA 2 -- int10--------
    rs1883225631,2
    --43525258(+) ATGACA/GTGCCA 2 -- int10--------
    rs1931849741,2
    --43525265(+) GCCACC/TGTATC 2 -- int10--------
    rs1845989451,2
    --43525302(+) GATAAA/TTATAT 2 -- int10--------
    rs575189261,2
    C,F--43525375(+) AGTATC/GTGGTT 2 -- int12Minor allele frequency- G:0.00WA CSA 3
    rs1882882091,2
    --43525427(+) AGGCTC/GCATCC 2 -- int10--------
    rs1447226721,2
    --43525463(+) TTTCTA/GTTTTT 2 -- int10--------
    rs1385229391,2
    --43525522(+) AAAACA/GAGACA 2 -- int10--------
    rs1414849261,2
    --43525542(+) TCCCCA/GTAACT 2 -- int10--------
    rs1912324251,2
    --43525554(+) TTCTTC/TCCCTG 2 -- int10--------
    rs1127336311,2
    C--43525676(+) AGCAAG/ATCCTA 2 -- int11Minor allele frequency- A:0.00CSA 1
    rs1837625061,2
    --43525822(+) TCTTTA/GCTAGT 2 -- int10--------
    rs1884388321,2
    --43525853(+) TTGCCC/TCACTA 2 -- int10--------
    rs1818743021,2
    --43525895(+) TCTTTA/TAAAAA 2 -- int10--------
    rs1857968351,2
    --43526075(+) CCTTAA/CTGGTC 2 -- int10--------
    rs736330161,2
    C--43526121(+) ATACTG/TGCATG 2 -- int11Minor allele frequency- T:0.00WA 2
    rs2008545221,2
    C--43526251(+) GGGGG-/AA/A  
      AG
    /GAA
    GCGGG
    6 -- int1 cds10--------
    rs1388682431,2
    --43526252(+) GGGGGA/GCGGGG 2 -- int10--------
    rs1820425091,2
    --43526294(+) ATGACG/TAGTCA 2 -- int10--------
    rs1861940691,2
    --43526296(+) GACGAA/GTCAAT 2 -- int10--------
    rs66092501,2
    C,F,A,H--43526353(+) TGCACG/ATTGTG 2 -- int18Minor allele frequency- A:0.17NA WA CSA 12
    rs1901218671,2
    --43526372(+) CCCTAA/GAACTT 2 -- int10--------
    rs1813575241,2
    --43526377(+) GAACTC/TAAAGT 2 -- int10--------
    rs1850510651,2
    --43526454(+) AAAAGC/GACTCC 2 -- int10--------
    rs65208941,2
    C,F,A,H--43526548(+) taatcT/Gtaata 2 -- int121Minor allele frequency- G:0.40NS EA NA WA CSA 1992
    rs1486713781,2
    --43526689(+) GAATAA/GATGAA 2 -- int10--------
    rs1129585971,2
    C,F--43526894(+) TACTAA/GTTTTC 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs59068831,2
    C,F,A,H--43526943(+) TATGCA/CGTACA 2 -- int125Minor allele frequency- N:0.00NS EA NA WA CSA 2605
    rs1898588901,2
    --43527007(+) ACTATA/GACCCA 2 -- int10--------
    rs23108831,2
    C,F,O,H--43527067(+) TGCAAG/CTATGA 2 -- int17Minor allele frequency- C:0.05NS EA NA WA 512
    rs1453349101,2
    --43527263(+) TAAGAC/GAGCTT 2 -- int10--------
    rs574055441,2
    C--43527274(+) GCTAGA/GATTGT 2 -- int10--------
    rs736330171,2
    C,F--43527465(+) ATATTA/TCTCCA 2 -- int12Minor allele frequency- T:0.00WA CSA 3
    rs1837955661,2
    C--43527466(+) TATTTC/TTCCAG 2 -- int10--------
    rs1891549561,2
    --43527474(+) CAGTTA/GTGAGT 2 -- int10--------
    rs1914061241,2
    --43527484(+) TGAGAC/TTGAAC 2 -- int10--------
    rs1502789971,2
    C--43527521(+) TTCTTC/TTGTAA 2 -- int10--------
    rs59068931,2
    C,F,A,H--43527624(+) ATGAAT/CTCTTT 2 -- int119Minor allele frequency- C:0.40NS EA WA NA CSA 1980
    rs1836843291,2
    --43527684(+) TGCACA/GGAAAG 2 -- int10--------
    rs1458034011,2
    --43527753(+) TTAAGA/GTTTTT 2 -- int10--------
    rs1876678861,2
    --43527821(+) TGCTTC/TACTTT 2 -- int10--------
    rs1426775451,2
    C--43527963(+) CACAAA/CTCTTT 2 -- int10--------
    rs1116814931,2
    C--43527971(+) TTTCTA/GCTGTA 2 -- int10--------
    rs1842907111,2
    --43528020(+) TAATGA/CTTTTT 2 -- int10--------
    rs1416577071,2
    --43528035(+) AATTTA/CCTGGC 2 -- int10--------
    rs1867016891,2
    --43528286(+) TTGAGC/TTGATG 2 -- int10--------
    rs613454811,2
    C--43528325(+) CCATCA/GTATTC 2 -- int10--------
    rs59069011,2
    C,A--43528520(+) AAATAG/CCCTGG 2 -- int14Minor allele frequency- C:0.00NA WA 6
    rs1417751231,2
    C--43528636(+) ACTCCA/GGCCTG 2 -- int10--------
    rs1506008851,2
    --43528717(+) TTTTCC/TTTTTG 2 -- int10--------
    rs1396281601,2
    --43529070(+) CAATGA/GACTTG 2 -- int10--------
    rs1427811621,2
    --43529184(+) TACATA/GATCAA 2 -- int10--------
    rs625897111,2
    F--43529241(+) ATGAGA/GCTTAG 2 -- int11Minor allele frequency- G:0.00NA 2
    rs1854197971,2
    --43529355(+) TGTTAC/TCTTGT 2 -- int10--------
    rs66108371,2
    C,F,H--43529604(+) TGTTTT/CTAAAC 2 -- int12Minor allele frequency- C:0.02NS 384
    rs563666531,2
    C--43530460(+) TTTTCA/GTGTGT 2 -- int10--------
    rs2002595941,2
    C--43530915(+) GCTAGC/TCAGTT 2 -- int10--------
    rs59069131,2
    C,F--43531255(+) ggatgG/Ccattg 2 -- int12Minor allele frequency- C:0.50NA 4
    rs1814821741,2
    --43531291(+) TGGCCA/GGTTTC 2 -- int10--------
    rs1852755021,2
    --43531339(+) TCTTCC/TATTTC 2 -- int10--------
    rs1891012361,2
    --43531364(+) TATTTC/TATTGA 2 -- int10--------
    rs1811462641,2
    --43531721(+) TTCCAA/GCACTA 2 -- int10--------
    rs1855922331,2
    --43532224(+) ATTCTC/TTCTTT 2 -- int10--------
    rs794870211,2
    C--43532593(+) ATTAGT/CCTTGC 2 -- int12Minor allele frequency- C:0.00NA 4
    rs2008389121,2
    --43532679(+) TTTGT-/GTGTCT 2 -- int10--------
    rs1896151651,2
    --43533026(+) TCCTGA/TGTTCT 2 -- int10--------
    rs1809271741,2
    --43533080(+) CTATTA/CTTTTA 2 -- int10--------
    rs1869846201,2
    --43533096(+) GCTGAA/GGAGAG 2 -- int10--------
    rs1922687471,2
    --43534689(+) CAACTC/TGTCAA 2 -- int10--------
    rs59069141,2
    C,F,A--43535471(+) AAGACA/GCCATG 2 -- int13Minor allele frequency- G:0.40NA WA 5
    rs1840534031,2
    --43535550(+) AAAGCA/GCAGTA 2 -- int10--------
    rs1860285151,2
    --43535560(+) ATTAGG/TGTGGG 2 -- int10--------
    rs1907442091,2
    --43535588(+) GGTGCC/TGTCTG 2 -- int10--------
    rs803378501,2
    C--43535612(-) TTTCCT/GAGTCA 2 -- int13Minor allele frequency- G:0.25NA CSA 4
    rs792565691,2
    C--43535678(-) GTGCAG/CGAGCC 2 -- int11Minor allele frequency- C:0.50CSA 2
    rs1825725841,2
    --43535691(+) TGCACC/TGCACC 2 -- int10--------
    rs59069151,2
    C,A--43535692(+) gcaccA/Gcaccc 2 -- int14Minor allele frequency- G:0.00NA WA CSA 6
    rs1487302761,2
    --43535713(+) GCCCAC/TTGTCT 2 -- int10--------
    rs1872334341,2
    --43535786(+) GCATCA/GCTCAT 2 -- int10--------
    rs736330181,2
    C,F--43535843(+) GCCCTT/CCAGTC 2 -- int12Minor allele frequency- C:0.00WA CSA 3
    rs1828694291,2
    --43535896(+) TCAACA/GAATAT 2 -- int10--------
    rs78826991,2
    C,F,H--43535927(+) gccagG/Atacta 2 -- int19Minor allele frequency- A:0.01NS EA NA 1192
    rs1513151531,2
    --43535948(+) TGGAGA/GTACAG 2 -- int10--------
    rs2020208901,2
    --43536367(+) GAGGT-/GGAGAAGG 2 -- int10--------
    rs1407176711,2
    --43536386(+) TAAGTA/GTGGAA 2 -- int10--------
    rs1443691371,2
    --43536649(+) CACTGC/GTGGCT 2 -- int10--------
    rs1466111361,2
    C--43536709(+) ATTGCC/TTTGAA 2 -- int10--------
    rs1877763861,2
    --43537012(+) GTGAAC/TGTAGT 2 -- int10--------
    rs560136161,2
    C--43537167(+) TAGACT/CTCTTC 2 -- int12Minor allele frequency- C:0.00WA CSA 3
    rs1932457411,2
    --43537656(+) TTTGCA/GTAATA 2 -- int10--------
    rs1856988571,2
    --43537664(+) ATAAAA/CTGTGA 2 -- int10--------
    rs1888631501,2
    --43537951(+) ATAATC/GCAAGA 2 -- int10--------
    rs14651071,2
    C,F,O,A,H--43538017(+) GCCACA/GGTTAT 2 -- int114Minor allele frequency- N:0.00EA NS NA WA CSA 519
    rs1922002891,2
    --43538099(+) TCCTAA/GCAGCA 2 -- int10--------
    rs14651081,2
    C,F,A,H--43538209(+) TTAGCA/GCCCAT 2 -- int115Minor allele frequency- G:0.48MN NS EA NA WA CSA 1413
    rs1838663651,2
    --43538388(+) GCTGTC/GATAGG 2 -- int10--------
    rs1885456021,2
    --43538795(+) TGCTAA/CTGAGA 2 -- int10--------
    rs1490227651,2
    --43539225(+) AAACAC/TATTGC 2 -- int10--------
    rs1814437851,2
    --43539294(+) TGTGAA/GCTGAT 2 -- int10--------
    rs1430298261,2
    C--43539319(+) ACATAC/TTTAAA 2 -- int10--------
    rs1860375661,2
    --43539351(+) GTAAGA/CGTAGT 2 -- int10--------
    rs1893008601,2
    --43539806(+) ATCCCC/GTCCCA 2 -- int10--------
    rs1822910621,2
    --43539815(+) CATTCC/GCTCTC 2 -- int10--------
    rs1865030141,2
    --43540258(+) ATTTCA/GTCTTT 2 -- int10--------
    rs59069381,2
    C,F,A,H--43540295(+) ctcctG/Aagtct 2 -- int120Minor allele frequency- A:0.40NS EA WA NA CSA 1990
    rs1904993941,2
    --43540339(+) TCTTGC/GTTTCT 2 -- int10--------
    rs1429090831,2
    --43540376(+) TTGTAC/TATTTC 2 -- int10--------
    rs1830668531,2
    --43540453(+) ACACTA/GTAAGT 2 -- int10--------
    rs1855207621,2
    --43540521(+) AAAACA/TAAGAA 2 -- int10--------
    rs1914128441,2
    C--43540652(+) ATGCTA/GAAAAA 2 -- int10--------
    rs1123471271,2
    C,F--43540776(+) AAAAAC/TGTGAA 2 -- int11Minor allele frequency- T:0.00NA 1
    rs59533851,2
    C,F,A,H--43540837(+) CGTGTG/ATTTTA 2 -- int120Minor allele frequency- A:0.40NS EA WA NA CSA 1990
    rs1878110521,2
    --43541029(+) GAGAAA/GTATAA 2 -- int10--------
    rs2003253031,2
    C--43541051(+) AACTA-/AGAC  
            
    AGAAT
    2 -- int10--------
    rs128436501,2
    --43541128(+) TATATT/ATTTTT 2 -- int12Minor allele frequency- A:0.00NA 4
    rs2016650761,2
    --43541128(+) TATAT-/ATTTTT 2 -- int10--------
    rs3686489351,2
    --43541129(+) TATAT-/ATTTTT 2 -- int10--------
    rs1831519861,2
    --43541130(+) TATATA/TTTTTT 2 -- int10--------
    rs48244981,2
    C,A,H--43541222(+) CCTCCT/CGGGTT 2 -- int15Minor allele frequency- C:0.00NA WA 8
    rs1878282381,2
    --43541287(+) ACCATA/GCCCAG 2 -- int10--------
    rs1919306571,2
    --43541348(+) ATGGTC/TTCGAT 2 -- int10--------
    rs1843112901,2
    --43541535(+) AAAAGC/GGACCA 2 -- int10--------
    rs23108841,2
    C,F,H--43541556(+) aagaaA/Ttgcct 2 -- int15Minor allele frequency- T:0.00NS EA NA 404
    rs78922821,2
    C,F,H--43541620(+) actagA/Gaagga 2 -- int1 trp36Minor allele frequency- G:0.02NS NA 890
    rs1133931891,2
    C,F--43541662(+) AGGGGT/CATGTC 2 -- int11Minor allele frequency- C:0.00CSA 1
    rs1901415261,2
    --43541678(+) GGCATA/CGGAGC 2 -- int10--------
    rs1928784661,2
    --43541730(+) AGCAAC/TGAAAT 2 -- int10--------
    rs126879611,2
    H--43541923(+) cactcC/Tttaag 2 -- int10--------
    rs1497589321,2
    --43541945(+) CATAGC/TCTTTT 2 -- int10--------
    rs1471268721,2
    C--43541978(+) AGAATA/TACTAT 2 -- int10--------
    rs126879741,2
    H--43542009(+) accacC/Ttcagc 2 -- int10--------
    rs1848829691,2
    --43542023(+) GTGATC/TAGATC 2 -- int10--------
    rs1397387961,2
    --43542214(+) AAGTAG/TGAAGC 2 -- int10--------
    rs1893414741,2
    --43542285(+) TAATCA/GAAATA 2 -- int10--------
    rs1445450261,2
    C--43542729(+) TTGAAC/TGTTAC 2 -- int10--------
    rs1413737881,2
    --43542966(+) AAGCCA/GTTTGT 2 -- int10--------
    rs587910671,2
    C--43543206(+) CACAG-/ACACACA 2 -- int10--------
    rs1809157691,2
    --43543467(+) GCTACA/GTCGCT 2 -- int10--------
    rs1863022691,2
    --43543489(+) ACTTCA/GGCTTA 2 -- int10--------
    rs1425574111,2
    C--43543587(+) AGTAGG/TCAGGG 2 -- int10--------
    rs1509455761,2
    --43543654(+) AGTGGA/GGGAGA 2 -- int10--------
    rs38381951,2
    C--43543787(+) CAAAA-/CAAAA 
            
    ACCCT
    2 -- int10--------
    rs1894802721,2
    --43543825(+) AAAACC/GCTCGC 2 -- int10--------
    rs1407889991,2
    --43543875(+) GAGTAC/TACAAA 2 -- int10--------
    rs2012739911,2
    --43544126(+) CTTTT-/CTTTTT 2 -- int10--------
    rs1820824411,2
    --43544127(+) CTTTTC/TTTTTT 2 -- int10--------
    rs1860612181,2
    --43544274(+) GCACCC/GCCCCC 2 -- int10--------
    rs1917300621,2
    --43544279(+) CCCCCC/GACCAC 2 -- int10--------
    rs1812217381,2
    --43544447(+) TTTGCA/GTGTAG 2 -- int10--------
    rs126880671,2
    C,F,H--43544506(+) agttcT/Ccattc 2 -- int13Minor allele frequency- C:0.25NA 8
    rs1470231141,2
    --43544736(+) AATAAC/TCTACA 2 -- int10--------
    rs1381068111,2
    --43544813(+) CATTTG/TCTTCC 2 -- int10--------
    rs1864670761,2
    --43544967(+) TCAGGA/CCCTAT 2 -- int10--------
    rs1495000051,2
    --43545027(+) CACTAC/TAGAAG 2 -- int10--------
    rs1909073471,2
    C--43545084(+) AATCCA/GGATTA 2 -- int10--------
    rs736330191,2
    C,F--43545233(+) CTCATT/CTGAGT 2 -- int11Minor allele frequency- C:0.00WA 2
    rs1483171921,2
    --43545347(+) TGTATG/TCCTTT 2 -- int10--------
    rs587952731,2
    C--43545467(+) TTAAAC/TAGGAG 2 -- int10--------
    rs1822437421,2
    --43545474(+) GGAGCA/GTTAGT 2 -- int10--------
    rs1132036861,2
    C--43545517(+) CTTTGC/TATAAG 2 -- int11Minor allele frequency- T:0.00CSA 1
    rs1868080901,2
    --43545577(+) ATTACC/TTTGCC 2 -- int10--------
    rs1395458461,2
    --43545633(+) TGTCTA/GTTCAG 2 -- int10--------
    rs1908458451,2
    --43545700(+) ATTAGA/GACTTA 2 -- int10--------
    rs1833979551,2
    --43545708(+) TTAGCA/GTTTAT 2 -- int10--------
    rs20646961,2
    C,A--43545859(+) CTGGGC/AAACAT 2 -- int16Minor allele frequency- A:0.00NA WA CSA 8
    rs20646971,2
    C,F,A--43545988(+) GTTGCA/GGTGAG 2 -- int17Minor allele frequency- G:0.20NA WA CSA 10
    rs20646981,2
    C,A--43546071(+) AAAAAA/GGAAAC 2 -- int1 trp34Minor allele frequency- G:0.00NA WA CSA 5
    rs1929439921,2
    --43546186(+) CTACTA/GTGGAT 2 -- int10--------
    rs1847421241,2
    --43546203(+) GTACCA/GGAATG 2 -- int10--------
    rs2004237251,2
    --43546232(+) GCAAG-/CCTGTT 2 -- int10--------
    rs1880167491,2
    --43546233(+) GCAAGC/GTGTTC 2 -- int10--------
    rs1912402711,2
    --43546245(+) GATGCA/GTCTTC 2 -- int10--------
    rs128395501,2
    H--43546460(+) CAGTGT/GTACCG 2 -- int14Minor allele frequency- G:0.00NS EA 410
    rs1137789231,2
    C,F--43546627(+) AACTCT/CCAGGA 2 -- int11Minor allele frequency- C:0.00CSA 1
    rs70510421,2
    C,F,H--43546669(+) ATTTAT/CTGGAG 2 -- int16Minor allele frequency- C:0.04NS EA WA CSA 383
    rs1837700841,2
    --43546689(+) CAGTTC/TTGTTC 2 -- int10--------
    rs1884452551,2
    --43547048(+) GTCATA/GCTCAA 2 -- int10--------
    rs59058091,2
    C,F,H--43547230(+) ctgccC/Gcctac 2 -- int18Minor allele frequency- G:0.15NA WA CSA 13
    rs1818830131,2
    --43547231(+) TGCCGA/CCTACA 2 -- int10--------
    rs59069571,2
    C,F,A,H--43547310(+) tgctcG/Aagacc 2 -- int113Minor allele frequency- A:0.43NS EA NA WA CSA 432
    rs1856717861,2
    --43547312(+) CTCAAG/TACCTT 2 -- int10--------
    rs1421299281,2
    C--43547382(+) CTTTAC/TGTGAC 2 -- int10--------
    rs1901381901,2
    --43547388(+) GTGACC/TTGCTC 2 -- int10--------
    rs1817946831,2
    --43547578(+) GGCTGC/GAGTGC 2 -- int10--------
    rs1863529111,2
    --43547592(+) GGGACA/GATCTC 2 -- int10--------
    rs1477714871,2
    C--43547607(+) CACTGC/TAGCCA 2 -- int10--------
    rs1411706081,2
    --43547796(+) CATCAC/GTGCAT 2 -- int10--------
    rs1912099781,2
    --43547898(+) TTTCTG/TCTTGA 2 -- int10--------
    rs1813175871,2
    --43547954(+) GTCCAC/TTAGAA 2 -- int10--------
    rs1125921731,2
    C,F--43548362(+) TCACTT/GTGTTG 2 -- int11Minor allele frequency- G:0.00NA 1
    rs1476284971,2
    C--43548473(+) CAGGCA/GCTGCC 2 -- int10--------
    rs1850102191,2
    --43548777(+) GTCTAA/GAGTTT 2 -- int10--------
    rs59069711,2
    C--43548788(+) ATCAAT/CATACT 2 -- int17Minor allele frequency- C:0.00WA NA CSA 11
    rs1898170361,2
    --43549285(+) TTTAGA/GAGCTC 2 -- int10--------
    rs1831371231,2
    --43549462(+) TACCTC/GCTCAA 2 -- int10--------
    rs1888339641,2
    --43549613(+) TTGCTA/GGCAGT 2 -- int10--------
    rs352352701,2
    C--43549993(+) TTTTT-/TCCTTT 2 -- int10--------
    rs66108421,2
    H--43550026(+) acttaG/Cagctg 2 -- int14Minor allele frequency- C:0.00NS EA 420
    rs1916647061,2
    --43550115(+) GAAAAC/GAAAAA 2 -- int10--------
    rs1834770811,2
    --43550237(+) ACAAAA/GAGGAT 2 -- int10--------
    rs1888193911,2
    --43550342(+) AATACA/GAGATC 2 -- int10--------
    rs1117170841,2
    C,F--43550349(+) GATCAA/GAGCCA 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs285937001,2
    C--43550628(+) AAAAAA/TAAAAA 2 -- int1 trp30--------
    rs1842742861,2
    --43550650(+) AAGATA/GAAAAT 2 -- int10--------
    rs1130356391,2
    F--43550663(+) AGATAC/TAATTA 2 -- int11Minor allele frequency- T:0.00CSA 1
    rs1386078811,2
    --43550784(+) AGTTAA/TCAGTG 2 -- int10--------
    rs1914829051,2
    --43550816(+) GATGGA/GTAGTG 2 -- int10--------
    rs1855653371,2
    --43551115(+) ATCCTC/TCAACA 2 -- int10--------
    rs1903869121,2
    --43551245(+) ACTGTA/GTAGAC 2 -- int10--------
    rs59069731,2
    C,F,A--43551287(+) CACACA/GCACGC 2 -- int14Minor allele frequency- G:0.33NA WA 6
    rs2015833701,2
    C--43551290(-) TGTGCA/GTGCGT 2 -- int10--------
    rs59069741,2
    C,F,A,H--43551321(+) GCCAGT/CGAGCT 2 -- int117Minor allele frequency- C:0.47NS EA NA WA CSA 663
    rs30273921,2
    C,F,H--43551400(+) GGGGAG/ATTGCT 2 -- int15Minor allele frequency- A:0.06NS EA WA 422
    rs673742171,2
    C--43551427(+) CCGAAG/-GCTGA 2 -- int11Minor allele frequency- -:0.00CSA 2
    rs1382023911,2
    C--43551499(+) GTGTAC/TTGATT 2 -- int10--------
    rs1816225541,2
    --43551560(+) AGGACA/CAAGGG 2 -- int10--------
    rs1427215151,2
    C--43551638(+) ATGGTA/GTAAAG 2 -- int10--------
    rs1851693181,2
    --43551660(+) TGTGAG/TAGTCC 2 -- int10--------
    rs1890565951,2
    --43551676(+) TGTGGA/GCAGAA 2 -- int10--------
    rs1811482641,2
    --43551677(+) GTGGGA/CAGAAG 2 -- int10--------
    rs1855402571,2
    --43551972(+) ACTGTA/GTTTAT 2 -- int10--------
    rs1880465401,2
    --43552087(+) TGACGC/GATTCT 2 -- int10--------
    rs2002973531,2
    C--43552469(+) GGTTA-/TTTTTTT 2 -- int10--------
    rs1460666861,2
    C--43552477(+) TTTTAA/CAAGAC 2 -- int10--------
    rs774829391,2
    C--43552536(-) CATTCA/C/TGCAAA 2 -- spa11CSA 1
    rs1808557151,2
    C--43552555(+) GATTAC/TGTAGA 3 Y syn1 ut510--------
    rs1487884031,2
    C--43552691(+) CTTTTA/CACCCA 2 -- int10--------
    rs413036971,2
    C,F--43552773(+) ATTGTA/GAAAGT 2 -- int12Minor allele frequency- G:0.06NA 33
    rs1508722841,2
    C--43552815(+) TCTTTC/TCTTGT 2 -- int10--------
    rs1872222281,2
    C--43552826(+) TTTCTG/TTTTTC 2 -- int10--------
    rs1919364051,2
    --43553152(+) AGCCTC/TTGAAC 2 -- int10--------
    rs1842362131,2
    --43553172(+) ATCCTC/TATTCT 2 -- int10--------
    rs9095251,2
    C,F,O,A,H--43553202(-) GAAATA/GAAGCA 2 -- int134Minor allele frequency- N:0.00EA NA NS WA CSA 3032
    rs1866548181,2
    --43553385(+) AAATCA/GAAGTT 2 -- int10--------
    rs1496909451,2
    C--43553527(+) CACCTC/TGGGCA 2 -- int10--------
    rs30273951,2
    C,F,H--43553528(+) ACCTCG/CGGCAA 2 -- int14Minor allele frequency- C:0.00