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Aliases for MAOA Gene

Aliases for MAOA Gene

  • Monoamine Oxidase A 2 3 5
  • Monoamine Oxidase Type A 3 4
  • EC 4 63
  • MAO-A 3 4
  • EC 1.4.3 63

External Ids for MAOA Gene

Previous GeneCards Identifiers for MAOA Gene

  • GC0XP041545
  • GC0XP041794
  • GC0XP042360
  • GC0XP042636
  • GC0XP043271
  • GC0XP043400
  • GC0XP043515
  • GC0XP041246

Summaries for MAOA Gene

Entrez Gene Summary for MAOA Gene

  • This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

GeneCards Summary for MAOA Gene

MAOA (Monoamine Oxidase A) is a Protein Coding gene. Diseases associated with MAOA include brunner syndrome and monoamine oxidase a deficiency. Among its related pathways are Metabolism and cytochrome P450. GO annotations related to this gene include oxidoreductase activity and primary amine oxidase activity. An important paralog of this gene is MAOB.

UniProtKB/Swiss-Prot for MAOA Gene

  • Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Tocris Summary for MAOA Gene

  • Monoamine Oxidases (MAO) catalyze the oxidation of monoamines such as dopamine, serotonin and adrenalin. They are found bound to the outer membrane of mitochondria in most cell types in the body. Two subtypes of MAO have been identified: MAO-A and MAO-B.

Gene Wiki entry for MAOA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAOA Gene

Genomics for MAOA Gene

Regulatory Elements for MAOA Gene

Promoters for MAOA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAOA on UCSC Golden Path with GeneCards custom track

Genomic Location for MAOA Gene

43,654,907 bp from pter
43,746,824 bp from pter
91,918 bases
Plus strand

Genomic View for MAOA Gene

Genes around MAOA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAOA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAOA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAOA Gene

Proteins for MAOA Gene

  • Protein details for MAOA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Amine oxidase [flavin-containing] A
    Protein Accession:
    Secondary Accessions:
    • B4DF46
    • Q16426

    Protein attributes for MAOA Gene

    527 amino acids
    Molecular mass:
    59682 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.

    Three dimensional structures from OCA and Proteopedia for MAOA Gene

    Alternative splice isoforms for MAOA Gene


neXtProt entry for MAOA Gene

Proteomics data for MAOA Gene at MOPED

Post-translational modifications for MAOA Gene

  • Ubiquitination at Lys 469
  • Modification sites at PhosphoSitePlus

Other Protein References for MAOA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for MAOA Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the flavin monoamine oxidase family.
  • Belongs to the flavin monoamine oxidase family.
genes like me logo Genes that share domains with MAOA: view

No data available for Gene Families for MAOA Gene

Function for MAOA Gene

Molecular function for MAOA Gene

GENATLAS Biochemistry:
monoamine oxidase A,overexpressed in female panic disorders
UniProtKB/Swiss-Prot CatalyticActivity:
RCH(2)NHR + H(2)O + O(2) = RCHO + RNH(2) + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Enzyme Numbers (IUBMB) for MAOA Gene

Gene Ontology (GO) - Molecular Function for MAOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051378 serotonin binding IEA --
genes like me logo Genes that share ontologies with MAOA: view
genes like me logo Genes that share phenotypes with MAOA: view

Human Phenotype Ontology for MAOA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MAOA Gene

MGI Knock Outs for MAOA:

Animal Model Products

miRNA for MAOA Gene

miRTarBase miRNAs that target MAOA

No data available for Transcription Factor Targets and HOMER Transcription for MAOA Gene

Localization for MAOA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAOA Gene

Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for MAOA Gene COMPARTMENTS Subcellular localization image for MAOA gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 2
nucleus 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MAOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane TAS 24252804
genes like me logo Genes that share ontologies with MAOA: view

Pathways & Interactions for MAOA Gene

genes like me logo Genes that share pathways with MAOA: view

Interacting Proteins for MAOA Gene

Gene Ontology (GO) - Biological Process for MAOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0007268 synaptic transmission TAS --
GO:0007269 neurotransmitter secretion TAS --
GO:0042133 neurotransmitter metabolic process TAS --
GO:0042135 neurotransmitter catabolic process IEA --
genes like me logo Genes that share ontologies with MAOA: view

No data available for SIGNOR curated interactions for MAOA Gene

Drugs & Compounds for MAOA Gene

(100) Drugs for MAOA Gene - From: Novoseek, DGIdb, HMDB, DrugBank, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isocarboxazid Approved Pharma inhibitor, Target 2
Moclobemide Approved Pharma inhibitor, Target, Enzyme 5
Phenelzine Approved Pharma inhibitor, Target, Enzyme, antagonist, substrate 6
Selegiline Approved, Investigational Pharma inhibitor, Target 26
Tranylcypromine Approved Pharma inhibitor, Target 21

(97) Additional Compounds for MAOA Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 2-(5-Methoxy-1H-indol-3-yl)ethanamine
  • 2-(5-Methoxyindol-3-yl)ethylamine
  • 3-(2-Aminoethyl)-5-methoxyindole
  • 5-Mot
  • 5MOT
  • (+/-)-alpha-(aminomethyl)-4-hydroxy-3-methoxy-Benzenemethanol
  • (+/-)-Normetanephrine
  • 3-Methoxy-Noradrenaline
  • 3-O-Methyl-Noradrenaline
  • 4-(2-Amino-1-hydroxyethyl)-2-methoxyphenol
  • 1-Methyl-1H-imidazole-4-ethanamine
  • 1-Methyl-4-(2-aminoethyl)imidazole
  • 1-Methyl-4-(b-aminoethyl)imidazole
  • 1-Methyl-4-(beta-aminoethyl)imidazole
  • 1-Methyl-4-histamine
  • (1-Aminoethyl)benzene
  • 1-Amino-1-phenylethane
  • 1-Fenylethylamin
  • 1-Phenyl-1-ethanamine
  • 1-Phenylethanamine
  • 3,4-Dihydroxyphenylglycolaldehyde
  • 3,4-Dihydroxyphenylglycolic aldehyde
  • a,3,4-Trihydroxy-Benzeneacetaldehyde
  • alpha,3,4-Trihydroxy-Benzeneacetaldehyde
genes like me logo Genes that share compounds with MAOA: view

Transcripts for MAOA Gene

Unigene Clusters for MAOA Gene

Monoamine oxidase A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAOA Gene

No ASD Table

Relevant External Links for MAOA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAOA Gene

mRNA expression in normal human tissues for MAOA Gene

Protein differential expression in normal tissues from HIPED for MAOA Gene

This gene is overexpressed in Placenta (12.0), Nasal epithelium (9.2), Nasopharynx (7.5), and Adipocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAOA Gene

SOURCE GeneReport for Unigene cluster for MAOA Gene Hs.183109

mRNA Expression by UniProt/SwissProt for MAOA Gene

Tissue specificity: Heart, liver, duodenum, blood vessels and kidney.
genes like me logo Genes that share expression patterns with MAOA: view

Protein tissue co-expression partners for MAOA Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MAOA Gene

Orthologs for MAOA Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAOA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAOA 36
  • 99 (a)
LOC743285 35
  • 98.8 (n)
  • 98.89 (a)
(Bos Taurus)
Mammalia MAOA 35
  • 84.95 (n)
  • 88.05 (a)
  • 88 (a)
(Canis familiaris)
Mammalia MAOA 36
  • 90 (a)
  • 86.65 (n)
  • 89.75 (a)
(Mus musculus)
Mammalia Maoa 16
Maoa 36
  • 87 (a)
Maoa 35
  • 85.19 (n)
  • 88.12 (a)
(Monodelphis domestica)
Mammalia MAOA 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia MAOA 36
  • 79 (a)
(Rattus norvegicus)
Mammalia Maoa 35
  • 84.57 (n)
  • 88 (a)
(Gallus gallus)
Aves MAOA 36
  • 72 (a)
(Anolis carolinensis)
Reptilia MAOA 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495198 35
  • 68.62 (n)
  • 70.76 (a)
(Danio rerio)
Actinopterygii mao 36
  • 69 (a)
Species with no ortholog for MAOA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAOA Gene

Gene Tree for MAOA (if available)
Gene Tree for MAOA (if available)

Paralogs for MAOA Gene

Paralogs for MAOA Gene

(1) SIMAP similar genes for MAOA Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MAOA: view

Variants for MAOA Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MAOA Gene

A polymorphism 1.2 kb upstream of the MAOA coding sequences consists of a 30-bp repeated sequence present in 3, 3.5, 4, or 5 copies. The polymorphism affect transcriptional activity of the MAOA gene promoter. Alleles with 3.5 or 4 copies of the repeat sequence are transcribed 2 to 10 times more efficiently than those with 3 or 5 copies of the repeat.

Sequence variations from dbSNP and Humsavar for MAOA Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1799835 - 43,731,838(+) AGGCC(G/T)TCTGG reference, missense
rs1800466 - 43,744,488(+) GTACA(A/G)ATACA reference, missense
VAR_036545 A breast cancer sample
rs77698881 - 43,728,231(+) CTCAC(A/G)AAGTG reference, missense
VAR_071963 -

Structural Variations from Database of Genomic Variants (DGV) for MAOA Gene

Variant ID Type Subtype PubMed ID
nsv517873 CNV Gain 19592680
esv21483 CNV Gain 19812545

Variation tolerance for MAOA Gene

Residual Variation Intolerance Score: 18.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAOA Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for MAOA Gene

MalaCards: The human disease database

(61) MalaCards diseases for MAOA Gene - From: OMIM, ClinVar, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
brunner syndrome
  • bruns
monoamine oxidase a deficiency
  • brunner syndrome
maoa-related behavior disorders
antisocial personality disorder
  • asocial personality
social phobia
  • phobia social
- elite association - COSMIC cancer census association via MalaCards
Search MAOA in MalaCards View complete list of genes associated with diseases


  • Brunner syndrome (BRUNS) [MIM:300615]: A form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. {ECO:0000269 PubMed:8211186}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MAOA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MAOA: view

No data available for Genatlas for MAOA Gene

Publications for MAOA Gene

  1. A non-additive interaction of a functional MAO-A VNTR and testosterone predicts antisocial behavior. (PMID: 17429405) SjAPberg R.L. … Goldman D. (Neuropsychopharmacology 2008) 3 23 25 26
  2. Early trauma and increased risk for physical aggression during adulthood: the moderating role of MAOA genotype. (PMID: 17534436) Frazzetto G. … Troisi A. (PLoS ONE 2007) 3 23 48 67
  3. Amine oxidases and monooxygenases in the in vivo metabolism of xenobiotic amines in humans: has the involvement of amine oxidases been neglected? (PMID: 17868200) Strolin Benedetti M. … Whomsley R. (Fundam Clin Pharmacol 2007) 23 25 26
  4. Transdermal selegiline for the treatment of major depressive disorder. (PMID: 19300583) Lee K.C. … Chen J.J. (Neuropsychiatr Dis Treat 2007) 23 25 26
  5. Transdermal selegiline: the new generation of monoamine oxidase inhibitors. (PMID: 16641841) Patkar A.A. … Masand P.S. (CNS Spectr 2006) 23 25 26

Products for MAOA Gene

Sources for MAOA Gene

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