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MAOA Gene

protein-coding   GIFtS: 72
GCID: GC0XP043515

Monoamine Oxidase A

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Monoamine Oxidase A1 2
Monoamine Oxidase Type A2 3
MAO-A2 3
EC 1.4.3.43 8
Amine Oxidase [Flavin-Containing] A2
EC 1.4.38

External Ids:    HGNC: 68331   Entrez Gene: 41282   Ensembl: ENSG000001892217   OMIM: 3098505   UniProtKB: P213973   

Export aliases for MAOA gene to outside databases

Previous GC identifers: GC0XP041545 GC0XP041794 GC0XP042360 GC0XP042636 GC0XP043271 GC0XP043400 GC0XP041246


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MAOA Gene:
This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the
oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results
in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including
antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
(provided by RefSeq, Jul 2012)

GeneCards Summary for MAOA Gene:
MAOA (monoamine oxidase A) is a protein-coding gene. Diseases associated with MAOA include antisocial personality disorder, and avoidant personality disorder. GO annotations related to this gene include primary amine oxidase activity. An important paralog of this gene is MAOB.

UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397
Function: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the
metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA
preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine

summary for MAOA Gene:
Monoamine Oxidases (MAO) catalyze the oxidation of monoamines such as dopamine, serotonin and adrenalin.
They are found bound to the outer membrane of mitochondria in most cell types in the body. Two subtypes of
monoamine oxidase have been identified: MAO-A and MAO-B. Both are found in neurons and astroglia, with MAO-A
also found in the liver, gastrointestinal tract and placenta and MAO-B in blood platelets. Abnormal
regulation of MAOs in the body has been associated with depression, substance abuse, attention deficit
disorder, and irregular sexual maturation.

Gene Wiki entry for MAOA (Monoamine oxidase A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_079573.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAOA gene promoter:
         MEF-2A   c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAOA promoter sequence
   Search Chromatin IP Primers for MAOA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAOA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.3   Ensembl cytogenetic band:  Xp11.3   HGNC cytogenetic band: Xp11.4-p11.3

MAOA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAOA gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP043515:  view genomic region     (about GC identifiers)

Start:
43,515,409 bp from pter      End:
43,606,068 bp from pter
Size:
90,660 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397 (See protein sequence)
Recommended Name: Amine oxidase [flavin-containing] A  
Size: 527 amino acids; 59682 Da
Cofactor: FAD
Subunit: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a
covalently bound flavin. Enzymatically active as monomer
Mass spectrometry: Mass=60512; Mass_error=6; Method=Electrospray; Range=1-527; Source=PubMed:11812236;
5 PDB 3D structures from and Proteopedia for MAOA:
1H8Q (3D)        2BXR (3D)        2BXS (3D)        2Z5X (3D)        2Z5Y (3D)    
Secondary accessions: B4DF46 Q16426
Alternative splicing: 2 isoforms:  P21397-1   P21397-2   

Explore the universe of human proteins at neXtProt for MAOA: NX_P21397

Explore proteomics data for MAOA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys469
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAOA (P21397) (see all 22)
     RQPVGRI  DYNNLWR  ERNLPSV  FPPVWNP 


    See MAOA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000231.1  NP_001257387.1  

    ENSEMBL proteins: 
     ENSP00000340684   ENSP00000440846  
    Reactome Protein details: P21397

    MAOA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MAOA
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MAOA
    GenScript Custom Purified and Recombinant Proteins Services for MAOA
    Novus Biologicals MAOA Protein
    Novus Biologicals MAOA Lysates
    Sino Biological Recombinant Protein for MAOA
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAOA

    MAOA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAOA
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MAOA
    OriGene Custom Antibody Services for MAOA
    Novus Biologicals MAOA Antibodies
    Abcam antibodies for MAOA (P21397, P27338)
    Cloud-Clone Corp. Antibodies for MAOA
    ThermoFisher Antibodies for MAOA
    LSBio Antibodies in human, mouse, rat for MAOA

    MAOA Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAOA
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAOA
    Cloud-Clone Corp. CLIAs for MAOA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001613 Flavin_amine_oxidase
     IPR002937 Amino_oxidase

    Graphical View of Domain Structure for InterPro Entry P21397

    ProtoNet protein and cluster: P21397

    1 Blocks protein domain: IPB001613 Flavin-containing amine oxidase signature

    UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397
    Similarity: Belongs to the flavin monoamine oxidase family


    MAOA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AOFA_HUMAN, P21397
    Function: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the
    metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA
    preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine
    Catalytic activity: RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2)

         Genatlas biochemistry entry for MAOA:
    monoamine oxidase A,overexpressed in female panic disorders

         Enzyme Numbers (IUBMB): EC 1.4.3.41 2 EC 1.4.32

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008131primary amine oxidase activity TAS--
    GO:0016491oxidoreductase activity ----
    GO:0050660flavin adenine dinucleotide binding ----
         
    MAOA for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MAOA:
     Decreased viability 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Maoa):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  nervous system 

    MAOA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Maoatm1Shih for MAOA

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAOA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAOA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAOA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAOA

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAOA:
    hsa-mir-22-3p (MIRT005902)

    Block miRNA regulation of human, mouse, rat MAOA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAOA (see all 13):
    hsa-miR-3163 hsa-miR-495 hsa-miR-767-3p hsa-miR-7-2* hsa-miR-1324 hsa-miR-3065-5p hsa-miR-624* hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidMAOA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAOA
    Predesigned siRNA for gene silencing in human, mouse, rat MAOA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAOA

    Clone
    Products:
         
    OriGene clones in human, mouse for MAOA (see all 7)
    OriGene ORF clones in mouse, rat for MAOA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAOA (NM_000240)
    Sino Biological Human cDNA Clone for MAOA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAOA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAOA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAOA
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAOA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAOA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AOFA_HUMAN, P21397: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    extracellular2
    nucleus2
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005741mitochondrial outer membrane TAS--
    GO:0016021integral component of membrane IEA--

    MAOA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAOA About   (see all 25)  
    See pathways by source

    SuperPathContained pathways About
    1Serotonin clearance from the synaptic cleft
    Enzymatic degradation of dopamine by COMT0.33
    Enzymatic degradation of Dopamine by monoamine oxidase0.00
    Serotonin clearance from the synaptic cleft0.33
    Metabolism of serotonin0.00
    melatonin degradation II0.00
    2Phenylalanine metabolism
    Phenylalanine metabolism0.36
    noradrenaline and adrenaline degradation0.31
    Tyrosine metabolism0.36
    phenylalanine degradation IV0.00
    phenylalanine utilization0.33
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neurotransmitter Clearance In The Synaptic Cleft0.00
    Neuronal System0.68
    Dopamine clearance from the synaptic cleft0.00
    5tryptophan utilization II
    tryptophan utilization II0.71
    superpathway of melatonin degradation0.00
    tryptophan utilization I0.71
    serotonin degradation0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for MAOA
        Tyrosine metabolism p.1 (dopamine)

    Selected BioSystems Pathways for MAOA (see all 15)
        Biogenic Amine Synthesis
    SIDS Susceptibility Pathways
    Oxidative Stress
    dopamine degradation
    serotonin degradation


    5 Reactome Pathways for MAOA
        Enzymatic degradation of dopamine by COMT
    Metabolism of serotonin
    Enzymatic degradation of Dopamine by monoamine oxidase
    Norepinephrine Neurotransmitter Release Cycle
    Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2

    1 PharmGKB Pathway for MAOA
        Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for MAOA) (see all 13):
        Glycine, serine and threonine metabolism
    Arginine and proline metabolism
    Histidine metabolism
    Tyrosine metabolism
    Phenylalanine metabolism


    MAOA for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAOA: 
              Amino Acid Metabolism II in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for MAOA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MAOA (P213972, 3 ENSP000003406844) via UniProtKB, MINT, STRING, and/or I2D (see all 94) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    NDRG1Q925973, ENSP000003199774I2D: score=3 STRING: ENSP00000319977
    ATP6V1B2P212812, ENSP000002763904MINT-4054731 STRING: ENSP00000276390
    YWHABP319463I2D: score=1 
    A2MP010232MINT-4054731
    ACTBP607092MINT-4054731
    ALPPP051872MINT-4054731
    APODP050902MINT-4054731
    ARL8BQ9NVJ22MINT-4054731
    ASAH1Q135102MINT-4054731
    ATP5A1P257052MINT-4054731
    ATP5BP065762MINT-4054731
    ATP6V0D1P614212MINT-4054731
    ATP6V1AP386062MINT-4054731
    AZU1P201602MINT-4054731
    CAPN6Q9Y6Q12MINT-4054731
    CKMT1AP125322MINT-4054731
    CKMT1BP125322MINT-4054731
    CTSGP083112MINT-4054731
    CYP11A1P051082MINT-4054731
    CYP19A1P115112MINT-4054731
    DDOSTP396562MINT-4054731
    DLSTP369572MINT-4054731
    GAPDHP044062MINT-4054731
    GBAP040622MINT-4054731
    GLB1P162782MINT-4054731
    GUSBP082362MINT-4054731
    HSPA5P110212MINT-4054731
    HSPD1P108092MINT-4054731
    MPOP051642MINT-4054731
    PRTN3P241582MINT-4054731
    SCARB2Q141082MINT-4054731
    SLC25A5P051412MINT-4054731
    SLC25A6P122362MINT-4054731
    STSP088422MINT-4054731
    TPP1O147732MINT-4054731
    VDAC1P217962MINT-4054731
    AANATENSP000002506154STRING: ENSP00000250615
    ADH1AENSP000002096684STRING: ENSP00000209668
    ADH1BENSP000003066064STRING: ENSP00000306606
    ADH4ENSP000002655124STRING: ENSP00000265512
    ADH6ENSP000003783594STRING: ENSP00000378359
    ADH7ENSP000002096654STRING: ENSP00000209665
    AKR1A1ENSP000003126064STRING: ENSP00000312606
    ALDH1A3ENSP000003322564STRING: ENSP00000332256
    ALDH1B1ENSP000003669274STRING: ENSP00000366927
    ALDH2ENSP000002617334STRING: ENSP00000261733
    ALDH3A2ENSP000003457744STRING: ENSP00000345774
    ALDH9A1ENSP000003468274STRING: ENSP00000346827
    AOX1ENSP000003638324STRING: ENSP00000363832
    COMTENSP000003545114STRING: ENSP00000354511
    CYP2C19ENSP000003603724STRING: ENSP00000360372
    CYP2C8ENSP000003603174STRING: ENSP00000360317
    CYP2C9ENSP000002606824STRING: ENSP00000260682
    CYP2D6ENSP000003538204STRING: ENSP00000353820
    CYP3A4ENSP000003379154STRING: ENSP00000337915
    CYP3A43ENSP000002223824STRING: ENSP00000222382
    CYP3A5ENSP000002229824STRING: ENSP00000222982
    DBHENSP000003767764STRING: ENSP00000376776
    DDCENSP000003506164STRING: ENSP00000350616
    HNMTENSP000002800974STRING: ENSP00000280097
    IDO1ENSP000002535134STRING: ENSP00000253513
    PNMTENSP000002695824STRING: ENSP00000269582
    SAT1ENSP000003685724STRING: ENSP00000368572
    SLC22A2ENSP000003559204STRING: ENSP00000355920
    ADH5ENSP000002964124STRING: ENSP00000296412
    ALDH3A1ENSP000002257404STRING: ENSP00000225740
    ALDH3B2ENSP000002550844STRING: ENSP00000255084
    ALDH7A1ENSP000003871234STRING: ENSP00000387123
    CYP2C18ENSP000002859794STRING: ENSP00000285979
    CYP3A7ENSP000003374504STRING: ENSP00000337450
    INMTENSP000000132224STRING: ENSP00000013222
    SAT2ENSP000002692984STRING: ENSP00000269298
    AKR1B1ENSP000002859304STRING: ENSP00000285930
    GLO1ENSP000003624634STRING: ENSP00000362463
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006576cellular biogenic amine metabolic process TAS8211186
    GO:0006805xenobiotic metabolic process TAS--
    GO:0007268synaptic transmission TAS--
    GO:0007269neurotransmitter secretion TAS--
    GO:0007610behavior ----

    MAOA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for MAOA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Rasagiline mesylate Selective, irreversible MAO-B inhibitor [161735-79-1]
    (R)-(-)-Deprenyl hydrochlorideMAO-B inhibitor[14611-52-0]
    MoclobemideReversible MAO-A inhibitor[71320-77-9]
    Lazabemide hydrochlorideSelective MAO-B inhibitor[103878-83-7]
    Bifemelane hydrochlorideMAO-A and MAO-B inhibitor[90293-01-9]

    Selected HMDB Compounds for MAOA (see all 43)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Methylhistamine1-Methyl-1H-imidazole-4-ethanamine (see all 21)501-75-7--
    1-Phenylethylaminea-phenylethylamine (see all 17)98-84-0--
    3,4-Dihydroxymandelaldehyde3,4-Dihydroxyphenylglycolaldehyde (see all 4)13023-73-9--
    3,4-DihydroxyphenylacetaldehydeProtocatechuatealdehyde (see all 2)5707-55-1--
    3-Methoxy-4-hydroxyphenylglycolaldehydea,4-dihydroxy-3-methoxy-Benzeneacetaldehyde (see all 4)17592-23-3--
    3-Methoxytyramine3-Methoxy-4-hydroxyphenylethyl amine (see all 7)554-52-9--
    4,6-Dihydroxyquinoline4,6-Quinolinediol (see all 2)3517-61-1--
    5-Hydroxyindoleacetaldehyde(5-hydroxy-1H-indol-3-yl)acetaldehyde (see all 6)1892-21-3--
    5-Hydroxykynurenamine5-Hydroxykynuramine (see all 3)708-23-6--
    5-Methoxytryptamine2-(5-Methoxy-1H-indol-3-yl)ethanamine (see all 10)608-07-1--

    Selected DrugBank Compounds for MAOA (see all 37)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Tranylcypromine-- 155-09-9targetinhibitor12504917 8749840 15351283 15276688 10548268 14574774 11752352 20655983 16495723 10027835 15049511 10494892 9829163
    Phenelzine-- 51-71-8targetantagonist17768678 17912044 14574774 11752352 7092487 19201819 16370964 18700056 9829163
    enzymesubstrate17768678 17912044 14574774 11752352 7092487 19201819 16370964 18700056 9829163 17768678
    PargylineBenzyl-methyl-2-propinylamin (see all 12)555-57-7targetinhibitor19300583 17823646 9564606 477738 16641841 17715422
    Phentermine-- 122-09-8targetantagonist11911838 11673765 10799660 10231134
    enzymeinhibitor11911838 11673765 10799660 10231134 11911838 10799660
    Moclobemide4-Chlor-N-(2-morpholinoethyl)benzamid (see all 11)71320-77-9targetinhibitor1705137 8875133 11752352
    enzymeinhibitor1705137 8875133 11752352 11752352
    SelegilineL-Deprenalin (see all 4)14611-51-9targetinhibitor19300583 17823646 16641841 17715422
    Almotriptan-- 181183-52-8enzymesubstrate12353056 12642466 15762767
    DopamineDopamin (see all 6)51-61-6enzymesubstrate15817751 18652859 20869994
    Flavin-Adenine Dinucleotide-- 146-14-5target--17139284 17016423 10592235
    FurazolidoneNitrofurazolidone (see all 3)67-45-8enzymeinhibitor12623758 2032659 10543364

    Selected Novoseek inferred chemical compound relationships for MAOA gene (see all 133)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    maoa 98.5 1084 17692293 (10), 19224413 (8), 11927135 (8), 15936529 (8) (see all 99)
    moclobemide 94.9 153 1546132 (5), 8612391 (3), 9663810 (3), 9174681 (3) (see all 99)
    clorgyline 91.8 98 1741773 (4), 9564606 (3), 1893487 (3), 8243537 (2) (see all 54)
    brofaromine 90.8 33 8430214 (4), 1967018 (2), 8313400 (2), 8313393 (2) (see all 22)
    befloxatone 90.4 36 8613928 (8), 12729662 (3), 7665725 (2), 9728902 (2) (see all 15)
    kynuramine 89.7 14 20504539 (1), 8990278 (1), 16139309 (1), 8443155 (1) (see all 12)
    toloxatone 88.5 10 1546145 (2), 1705137 (2), 1424410 (2), 8713690 (1) (see all 6)
    tyramine 85.5 68 17561096 (4), 8255365 (3), 8695909 (2), 7665725 (2) (see all 37)
    pirlindole 83.5 16 8953568 (3), 9564636 (2), 12781338 (2), 9272198 (2) (see all 7)
    1-phenylcyclopropylamine 81.4 3 15755651 (1), 15848762 (1)



    MAOA for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for MAOA gene (2 alternative transcripts): 
    NM_000240.3  NM_001270458.1  

    Unigene Cluster for MAOA:

    Monoamine oxidase A
    Hs.183109  [show with all ESTs]
    Unigene Representative Sequence: NM_001270458
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338702(uc004dfy.3 uc011mkw.2) ENST00000497485 ENST00000490604
    ENST00000542639
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MAOA (see all 13):
    hsa-miR-3163 hsa-miR-495 hsa-miR-767-3p hsa-miR-7-2* hsa-miR-1324 hsa-miR-3065-5p hsa-miR-624* hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidMAOA 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat MAOA
      QuantiFast Probe-based Assays in human, mouse, rat MAOA

    Additional mRNA sequence: 

    AK123241.1 AK223499.1 AK291769.1 AK293926.1 BC008064.2 BC044787.1 BT006651.1 M68840.1 
    X17192.1 

    11 DOTS entries:

    DT.95120451  DT.87015236  DT.101981844  DT.100025285  DT.100825058  DT.121278195  DT.100708824  DT.121278204 
    DT.95120454  DT.100718004  DT.70102839 

    Selected AceView cDNA sequences (see all 267):

    AI674356 AW511315 BU684121 R97085 CA444528 AA865791 BM923944 AA995668 
    F02245 AI076531 BQ717463 N29331 AW873998 BQ716421 AI890731 NM_000240 
    AW627528 BG534382 BF448960 N30236 H82430 CK818786 R86250 AI335934 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAOA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGAAGTTT
    MAOA Expression
    About this image


    MAOA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             White adipocyte-like cells
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
             Alveolar type II cells
    MAOA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAOA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.183109

    UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397
    Tissue specificity: Heart, liver, duodenum, blood vessels and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including MAOA: 
              Amino Acid Metabolism II in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAOA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for MAOA gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Maoa1 , 5 monoamine oxidase A1, 5 85.19(n)1
    88.12(a)1
      X (11.78 cM)5
    171611  NM_173740.31  NP_776101.31 
     166196985 
    chicken
    (Gallus gallus)
    Aves MAOA6
    Gallus gallus monoamine oxidase A (MAOA), nuclear ...
    72(a)
    1 ↔ 1
    1(110613430-110658911)
    lizard
    (Anolis carolinensis)
    Reptilia MAOA6
    monoamine oxidase A
    72(a)
    1 ↔ 1
    3(135069134-135125415)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004951981 amine oxidase [flavin-containing] A-like 68.62(n)
    70.76(a)
      100495198  XM_002932798.2  XP_002932844.2 
    zebrafish
    (Danio rerio)
    Actinopterygii mao6
    monoamine oxidase
    69(a)
    1 → many
    9(34618751-34683759) ENSDARG00000023712


    ENSEMBL Gene Tree for MAOA (if available)
    TreeFam Gene Tree for MAOA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAOA gene
    MAOB2  
    1 SIMAP similar gene for MAOA using alignment to 7 protein entries:     AOFA_HUMAN (see all proteins):
    MAOB

    MAOA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    AOFA_HUMAN, P21397: A polymorphism 1.2 kb upstream of the MAOA coding sequences consists of a 30-bp repeated sequence
    present in 3, 3.5, 4, or 5 copies. The polymorphism affect transcriptional activity of the MAOA gene promoter.
    Alleles with 3.5 or 4 copies of the repeat sequence are transcribed 2 to 10 times more efficiently than those
    with 3 or 5 copies of the repeat


    Selected SNPs for MAOA (see all 1109)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365454
    A breast cancer sample4--see VAR_0365452 D E mis40--------
    rs725546321,2
    Cpathogenic143591031(+) TAATTC/TAGCGG 4 Q * stg10--------
    rs1923952121,2
    --43512260(+) AGGATC/TGAGGC 2 -- us2k10--------
    rs66518041,2
    C,F--43512290(+) caGTCA/GGCCTC 2 -- us2k12Minor allele frequency- G:0.00WA CSA 3
    rs66518051,2
    C,F--43512293(+) TCGGCT/CTCAGC 2 -- us2k12Minor allele frequency- C:0.00WA CSA 3
    rs48246571,2
    C,F,A,H--43512302(+) GCAGCC/GTTGTC 2 -- us2k110Minor allele frequency- G:0.32NA WA CSA 19
    rs1904159451,2
    --43512369(+) TTTTTC/TCTACC 2 -- us2k10--------
    rs1118209341,2
    C,F--43512512(+) ACATTC/TGTCAG 2 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs1816096531,2
    --43512744(+) GATTTC/TTTCAT 2 -- us2k10--------
    rs1843172791,2
    --43512882(+) CATATG/TTCTTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAOA (43515409 - 43606068 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MAOA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv21483CNV Gain19812545
    nsv517873CNV Gain19592680

    Human Gene Mutation Database (HGMD): MAOA
    Locus Specific Mutation Databases (LSDB): MAOA

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for MAOA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 309850   
    OMIM disorders: 300615  
    UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397
  • Brunner syndrome (BRUNS) [MIM:300615]: A form of X-linked non-dysmorphic mild mental retardation. Male
    patients are affected by borderline mental retardation and exhibit abnormal behavior, including disturbed
    regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for MAOA (see all 114):    
    About MalaCards
    antisocial personality disorder    avoidant personality disorder    maoa-related behavior disorders    monoamine oxidase a deficiency
    social phobia    brunner syndrome    personality disorder    paranoid schizophrenia
    substance abuse    serotonin syndrome    anxiety disorder    conduct disorder
    exhibitionism    melancholia    borderline personality disorder    postpartum depression
    hepatic encephalopathy    specific phobia    norrie disease    agoraphobia

    13 diseases from the University of Copenhagen DISEASES database for MAOA:
    Parkinson's disease     Anxiety disorder     Antisocial personality disorder     Conduct disorder
    Attention deficit hyperactivity disorder     Endogenous depression     Schizophrenia     Toxic encephalopathy
    Melancholia     Alcohol dependence     Avoidant personality disorder     Borderline personality disorder
    Migraine

    MAOA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for MAOA gene (see all 76)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    antisocial behavior 75.8 57 17008143 (4), 18023041 (3), 19120058 (3), 10359483 (2) (see all 20)
    borderline mental retardation 74.5 3 8776592 (1), 9326944 (1), 8613523 (1)
    antisocial personality disorder 65.4 32 12824808 (5), 17007976 (3), 10049583 (2), 20175604 (2) (see all 10)
    major depression 64.7 65 18337637 (4), 10564737 (4), 17884271 (4), 9179504 (3) (see all 28)
    aggressive behavior 63 36 15817751 (3), 15211623 (2), 18996506 (2), 17657171 (2) (see all 22)
    crisis hypertensive 59.4 7 17554106 (1), 9829163 (1), 14697896 (1), 19527191 (1)
    attention-deficit hyperactivity disorder 55.8 15 17230031 (2), 8862874 (1), 12140786 (1), 19309535 (1) (see all 13)
    bipolar disorder 53.7 47 10402508 (4), 8776592 (3), 9342194 (3), 16958037 (3) (see all 21)
    phobia social 53.6 8 8313403 (2), 10361959 (1), 8619339 (1), 9534836 (1) (see all 5)
    parkinson disease 52.5 32 7593732 (3), 17044053 (2), 8358501 (2), 9579294 (2) (see all 22)

    Genetic Association Database (GAD): MAOA
    Human Genome Epidemiology (HuGE) Navigator: MAOA (290 documents)

    Export disorders for MAOA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for MAOA gene, integrated from 10 sources (see all 1107):
    (articles sorted by number of sources associating them with MAOA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A non-additive interaction of a functional MAO-A VNTR and testosterone predicts antisocial behavior. (PubMed id 17429405)1, 4, 7, 9 SjAPberg R.L....Goldman D. (Neuropsychopharmacology 2008)
    2. Early trauma and increased risk for physical aggression during adulthood: the moderating role of MAOA genotype. (PubMed id 17534436)1, 4, 9 Frazzetto G....Troisi A. (PLoS ONE 2007)
    3. A promoter polymorphism in the monoamine oxidase A gene is associated with the pineal MAOA activity in Alzheimer's disease patients. (PubMed id 17692293)1, 4, 9 Wu Y.H....Swaab D.F. (Brain Res. 2007)
    4. [Association study of the polymorphisms of monoamine oxidase A genes with schizophrenia]. (PubMed id 17680543)1, 4, 9 Shi Y.Z....Lou B.Y. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007)
    5. Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B. (PubMed id 16129825)1, 2, 9 De Colibus L.... Mattevi A. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    6. Analysis of monoamine oxidase A (MAOA) promoter polymorphism in Finnish male alcoholics. (PubMed id 11927135)1, 4, 9 Saito T....Tiihonen J. (Psychiatry Res 2002)
    7. Structure of human monoamine oxidase A at 2.2-A resolution: the control of opening the entry for substrates/inhibitors. (PubMed id 18391214)1, 2, 9 Son S.-Y.... Tsukihara T. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    8. Effects of MAOA-genotype, alcohol consumption, and aging on violent behavior. (PubMed id 19120058)1, 4, 9 Tikkanen R....Virkkunen M. (Alcohol. Clin. Exp. Res. 2009)
    9. The development of peripartum depressive symptoms is associated with gene polymorphisms of MAOA, 5-HTT and COMT. (PubMed id 19625011)1, 4, 9 Doornbos B....Korf J. (amp 2009)
    10. MAOA gene polymorphisms and response to mirtazapine in major depression. (PubMed id 19382113)1, 4, 9 Tzeng D.S....Yang C.Y. (Hum Psychopharmacol 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 4128 HGNC: 6833 AceView: MAOA Ensembl:ENSG00000189221 euGenes: HUgn4128
    ECgene: MAOA Kegg: 4128 H-InvDB: MAOA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAOA Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=MAOA[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/Monoamine_oxidase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for MAOA gene:
    Search GeneIP for patents involving MAOA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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