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Aliases for MAOA Gene

Aliases for MAOA Gene

  • Monoamine Oxidase A 2 3
  • Monoamine Oxidase Type A 3 4
  • EC 4 63
  • MAO-A 3 4
  • Amine Oxidase [Flavin-Containing] A 3
  • EC 1.4.3 63

External Ids for MAOA Gene

Previous GeneCards Identifiers for MAOA Gene

  • GC0XP041545
  • GC0XP041794
  • GC0XP042360
  • GC0XP042636
  • GC0XP043271
  • GC0XP043400
  • GC0XP043515
  • GC0XP041246

Summaries for MAOA Gene

Entrez Gene Summary for MAOA Gene

  • This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

GeneCards Summary for MAOA Gene

MAOA (Monoamine Oxidase A) is a Protein Coding gene. Diseases associated with MAOA include brunner syndrome and maoa-related behavior disorders. Among its related pathways are Metabolism and Arginine and proline metabolism. GO annotations related to this gene include primary amine oxidase activity. An important paralog of this gene is MAOB.

UniProtKB/Swiss-Prot for MAOA Gene

  • Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine

Tocris Summary for MAOA Gene

  • Monoamine Oxidases (MAO) catalyze the oxidation of monoamines such as dopamine, serotonin and adrenalin. They are found bound to the outer membrane of mitochondria in most cell types in the body. Two subtypes of monoamine oxidase have been identified: MAO-A and MAO-B. Both are found in neurons and astroglia, with MAO-A also found in the liver, gastrointestinal tract and placenta and MAO-B in blood platelets. Abnormal regulation of MAOs in the body has been associated with depression, substance abuse, attention deficit disorder, and irregular sexual maturation.

Gene Wiki entry for MAOA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAOA Gene

Genomics for MAOA Gene

Regulatory Elements for MAOA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAOA Gene

43,654,907 bp from pter
43,746,824 bp from pter
91,918 bases
Plus strand

Genomic View for MAOA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAOA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAOA Gene

Proteins for MAOA Gene

  • Protein details for MAOA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Amine oxidase [flavin-containing] A
    Protein Accession:
    Secondary Accessions:
    • B4DF46
    • Q16426

    Protein attributes for MAOA Gene

    527 amino acids
    Molecular mass:
    59682 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.

    Three dimensional structures from OCA and Proteopedia for MAOA Gene

    Alternative splice isoforms for MAOA Gene


neXtProt entry for MAOA Gene

Proteomics data for MAOA Gene at MOPED

Post-translational modifications for MAOA Gene

  • Ubiquitination at Lys469
  • Modification sites at PhosphoSitePlus

Other Protein References for MAOA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for MAOA Gene

Protein Domains for MAOA Gene

Graphical View of Domain Structure for InterPro Entry



  • P21397
  • Belongs to the flavin monoamine oxidase family.
genes like me logo Genes that share domains with MAOA: view

No data available for Gene Families for MAOA Gene

Function for MAOA Gene

Molecular function for MAOA Gene

GENATLAS Biochemistry:
monoamine oxidase A,overexpressed in female panic disorders
UniProtKB/Swiss-Prot CatalyticActivity:
RCH(2)NHR + H(2)O + O(2) = RCHO + RNH(2) + H(2)O(2)
UniProtKB/Swiss-Prot Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine

Enzyme Numbers (IUBMB) for MAOA Gene

Gene Ontology (GO) - Molecular Function for MAOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008131 primary amine oxidase activity TAS --
GO:0016491 oxidoreductase activity --
GO:0050660 flavin adenine dinucleotide binding --
genes like me logo Genes that share ontologies with MAOA: view
genes like me logo Genes that share phenotypes with MAOA: view

Animal Models for MAOA Gene

MGI Knock Outs for MAOA:

Animal Model Products

miRNA for MAOA Gene

miRTarBase miRNAs that target MAOA

No data available for Transcription Factor Targeting and HOMER Transcription for MAOA Gene

Localization for MAOA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAOA Gene

Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.

Subcellular locations from

Jensen Localization Image for MAOA Gene COMPARTMENTS Subcellular localization image for MAOA gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 2
nucleus 2
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MAOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 20833797
GO:0005741 mitochondrial outer membrane TAS 24252804
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MAOA: view

Pathways for MAOA Gene

genes like me logo Genes that share pathways with MAOA: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for MAOA Gene

Gene Ontology (GO) - Biological Process for MAOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006576 cellular biogenic amine metabolic process TAS 8211186
GO:0006805 xenobiotic metabolic process TAS --
GO:0007268 synaptic transmission TAS --
GO:0007269 neurotransmitter secretion TAS --
GO:0042135 neurotransmitter catabolic process IEA --
genes like me logo Genes that share ontologies with MAOA: view

Compounds for MAOA Gene

(5) Tocris Compounds for MAOA Gene

Compound Action Cas Number
(R)-(-)-Deprenyl hydrochloride MAO-B inhibitor [14611-52-0]
Bifemelane hydrochloride MAO-A and MAO-B inhibitor [62232-46-6]
Lazabemide hydrochloride Selective MAO-B inhibitor [103878-83-7]
Moclobemide Reversible MAO-A inhibitor [71320-77-9]
Rasagiline mesylate Selective, irreversible MAO-B inhibitor [161735-79-1]

(4) ApexBio Compounds for MAOA Gene

Compound Action Cas Number
Moclobemide (Ro 111163) Reversible inhibitor of MAO-A [71320-77-9]
Paeonol MAO inhibitor;multi-functional phenolic compound [552-41-0]
Procarbazine HCl Antineoplastic chemotherapy drug [366-70-1]
Sennoside A Irritant laxative;mild MAO inhibitor [81-27-6]

(43) HMDB Compounds for MAOA Gene

Compound Synonyms Cas Number PubMed IDs
  • 1-Methyl-1H-imidazole-4-ethanamine
  • a-phenylethylamine
  • 3,4-Dihydroxyphenylglycolaldehyde
  • Protocatechuatealdehyde
  • a,4-dihydroxy-3-methoxy-Benzeneacetaldehyde

(40) Drugbank Compounds for MAOA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
23239-32-9 target inhibitor
181183-52-8 enzyme substrate
487-93-4 enzyme

(133) Novoseek inferred chemical compound relationships for MAOA Gene

Compound -log(P) Hits PubMed IDs
maoa 98.5 455
moclobemide 94.9 127
clorgyline 91.8 72
brofaromine 90.8 29
befloxatone 90.4 28
genes like me logo Genes that share compounds with MAOA: view

Transcripts for MAOA Gene

Unigene Clusters for MAOA Gene

Monoamine oxidase A:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAOA

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAOA Gene

No ASD Table

Relevant External Links for MAOA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAOA Gene

mRNA expression in normal human tissues for MAOA Gene

Protein differential expression in normal tissues for MAOA Gene

This gene is overexpressed in Placenta (12.0), Nasal epithelium (9.2), Nasopharynx (7.5), and Adipocyte (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAOA Gene

SOURCE GeneReport for Unigene cluster for MAOA Gene Hs.183109

mRNA Expression by UniProt/SwissProt for MAOA Gene

Tissue specificity: Heart, liver, duodenum, blood vessels and kidney
genes like me logo Genes that share expressions with MAOA: view

Expression partners for MAOA Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MAOA Gene

Orthologs for MAOA Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAOA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MAOA 35
  • 84.95 (n)
  • 88.05 (a)
  • 88 (a)
(Canis familiaris)
Mammalia MAOA 35
  • 86.65 (n)
  • 89.75 (a)
  • 90 (a)
(Mus musculus)
Mammalia Maoa 35
  • 85.19 (n)
  • 88.12 (a)
Maoa 16
Maoa 36
  • 87 (a)
(Pan troglodytes)
Mammalia LOC743285 35
  • 98.8 (n)
  • 98.89 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Maoa 35
  • 84.57 (n)
  • 88 (a)
(Monodelphis domestica)
Mammalia MAOA 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia MAOA 36
  • 79 (a)
(Gallus gallus)
Aves MAOA 36
  • 72 (a)
(Anolis carolinensis)
Reptilia MAOA 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495198 35
  • 68.62 (n)
  • 70.76 (a)
(Danio rerio)
Actinopterygii mao 36
  • 69 (a)
Species with no ortholog for MAOA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAOA Gene

Gene Tree for MAOA (if available)
Gene Tree for MAOA (if available)

Paralogs for MAOA Gene

Paralogs for MAOA Gene

Selected SIMAP similar genes for MAOA Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MAOA: view

Variants for MAOA Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MAOA Gene

A polymorphism 1.2 kb upstream of the MAOA coding sequences consists of a 30-bp repeated sequence present in 3, 3.5, 4, or 5 copies. The polymorphism affect transcriptional activity of the MAOA gene promoter. Alleles with 3.5 or 4 copies of the repeat sequence are transcribed 2 to 10 times more efficiently than those with 3 or 5 copies of the repeat

Sequence variations from dbSNP and Humsavar for MAOA Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs6323 other 43,731,789(+) CAGCG(G/T)CTTCC reference, synonymous-codon
rs909525 -- 43,693,955(-) GAAAT(A/G)AAGCA intron-variant
rs979605 -- 43,742,116(-) TTGCA(C/T)TGAAC intron-variant
rs979606 -- 43,741,895(-) GCTGC(A/G)AGTCA intron-variant
rs1137068 -- 43,728,306(+) CCAAT(G/T)GTGGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MAOA Gene

Variant ID Type Subtype PubMed ID
nsv517873 CNV Gain 19592680
esv21483 CNV Gain 19812545

Relevant External Links for MAOA Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

Disorders for MAOA Gene

(1) OMIM Diseases for MAOA Gene (309850)


  • Brunner syndrome (BRUNS) [MIM:300615]: A form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. {ECO:0000269 PubMed:8211186}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(76) Novoseek inferred disease relationships for MAOA Gene

Disease -log(P) Hits PubMed IDs
antisocial behavior 75.8 30
borderline mental retardation 74.5 3
antisocial personality disorder 65.4 18
major depression 64.7 50
aggressive behavior 63 28

Relevant External Links for MAOA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MAOA: view

No data available for Genatlas for MAOA Gene

Publications for MAOA Gene

  1. A non-additive interaction of a functional MAO-A VNTR and testosterone predicts antisocial behavior. (PMID: 17429405) SjAPberg R.L. … Goldman D. (Neuropsychopharmacology 2008) 3 23 25 48
  2. A new look at the promoter of the human monoamine oxidase A gene: mapping transcription initiation sites and capacity to drive luciferase expression. (PMID: 7519662) Denney R.M. … Waguespack A. (J. Neurochem. 1994) 3 4 23
  3. Promoter organization and activity of human monoamine oxidase (MAO) A and B genes. (PMID: 1432104) Zhu Q.S. … Shih J.C. (J. Neurosci. 1992) 3 4 23
  4. Structure of the human gene for monoamine oxidase type A. (PMID: 1886775) Chen Z.-Y. … Hsu Y.-P.P. (Nucleic Acids Res. 1991) 3 4 23
  5. Human monoamine oxidase A and B genes exhibit identical exon-intron organization. (PMID: 2023912) Grimsby J. … Shih J.C. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4 23

Products for MAOA Gene

Sources for MAOA Gene

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