Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MAOA Gene

protein-coding GIFtS: 71
GCID: GC0XP043515

monoamine oxidase A

Explore 111 diseases affiliated with
MAOA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Monoamine Oxidase A¹ ²
Monoamine Oxidase Type A² ³
MAO-A² ³
EC 1.4.3.4³ ⁸
Amine Oxidase [Flavin-Containing] A²
EC 1.4.3⁸

External Ids:	HGNC: 6833¹	Entrez Gene: 4128²	Ensembl: ENSG00000189221⁷	OMIM: 309850⁵	UniProtKB: P21397³

Export aliases for MAOA gene to outside databases

Previous GC identifers: GC0XP041545 GC0XP041794 GC0XP042360 GC0XP042636 GC0XP043271 GC0XP043400 GC0XP041246

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MAOA:

This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative

deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner

syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial

behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. (provided by

RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397

Function: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the

metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA

preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine

summary for MAOA:

Monoamine Oxidases (MAO) catalyze the oxidation of monoamines such as dopamine, serotonin and adrenalin.

They are found bound to the outer membrane of mitochondria in most cell types in the body. Two subtypes of

monoamine oxidase have been identified: MAO-A and MAO-B. Both are found in neurons and astroglia, with MAO-A

also found in the liver, gastrointestinal tract and placenta and MAO-B in blood platelets. Abnormal

regulation of MAOs in the body has been associated with depression, substance abuse, attention deficit

disorder, and irregular sexual maturation.

Gene Wiki entry for MAOA (Monoamine oxidase A)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_079573.4

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MAOA gene promoter:
MEF-2A c-Fos AP-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAOA promoter sequence

Search SABiosciences Chromatin IP Primers for MAOA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAOA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.3 Ensembl cytogenetic band: Xp11.3 HGNC cytogenetic band: Xp11.4-p11.3

MAOA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAOA gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP043515: view genomic region (about GC identifiers)

Start:	43,515,409 bp from pter	End:	43,606,068 bp from pter
Size:	90,660 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397 (See protein sequence)

Recommended Name: Amine oxidase [flavin-containing] A

Size: 527 amino acids; 59682 Da

Cofactor: FAD

Subunit: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently

bound flavin. Enzymatically active as monomer

Subcellular location: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side

Mass spectrometry: Mass=60512; Mass_error=6; Method=Electrospray; Range=1-527; Source=PubMed:11812236;

5 PDB 3D structures from and Proteopedia for MAOA:

1H8Q (3D)

2BXR (3D)

2BXS (3D)

2Z5X (3D)

2Z5Y (3D)

Secondary accessions: B4DF46 Q16426

Alternative splicing: 2 isoforms: P21397-1 P21397-2

Explore the universe of human proteins at neXtProt for MAOA: NX_P21397

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P21397

4/22 DME Specific Peptides for MAOA (P21397) (see all 22)

RQPVGRI

DYNNLWR

ERNLPSV

FPPVWNP

MAOA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000231.1 NP_001257387.1

ENSEMBL proteins:

ENSP00000340684 ENSP00000440846

Reactome Protein details: P21397
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: MAOA OriGene Custom Protein Services for MAOA
	GenScript Custom Purified and Recombinant Proteins Services for MAOA
	Novus Biologicals MAOA Protein Novus Biologicals MAOA Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MAOA

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	--	--
GO:0005739	mitochondrion	--	--
GO:0005741	mitochondrial outer membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

MAOA for ontologies About GeneDecksing

MAOA Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of MAOA
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 4): MAOA OriGene Custom Antibody Services for MAOA
	GenScript Custom Superior Antibodies Services for MAOA
	Novus Biologicals MAOA Antibodies
	Abcam antibodies for MAOA
	Uscn Antibodies for MAOA
	ThermoFisher Antibodies for MAOA

Assay Products for MAOA:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MAOA
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MAOA

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MAOA for domains About GeneDecksing

2 InterPro domains/families:

IPR001613 Flavin_amine_oxidase

IPR002937 Amino_oxidase

Graphical View of Domain Structure for InterPro Entry P21397

ProtoNet protein and cluster: P21397

1 Blocks protein family: IPB001613 Flavin-containing amine oxidase signature

UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397

Similarity: Belongs to the flavin monoamine oxidase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397

Function: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the

metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA

preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine

Catalytic activity: RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2)

Genatlas biochemistry entry for MAOA:

monoamine oxidase A,overexpressed in female panic disorders

Enzyme Numbers (IUBMB): EC 1.4.3.4¹ ² EC 1.4.3²

miRNA Products:		miRTarBase miRNAs that target MAOA: hsa-mir-22 (MIRT005902)

		OriGene 3'-UTR Clone: MAOA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAOA
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate MAOA (see all 13):
		hsa-miR-3163 hsa-miR-495 hsa-miR-767-3p hsa-miR-7-2* hsa-miR-1324 hsa-miR-3065-5p hsa-miR-624* hsa-miR-29b-1*

		SwitchGear 3'UTR luciferase reporter plasmid: MAOA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAOA (see all 4) OriGene shRNA RFP: MAOA OriGene siRNA: MAOA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAOA

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MAOA

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAOA (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAOA OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MAOA (NM_000240)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAOA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAOA

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MAOA
		Search LifeMap BioReagents cell lines for MAOA

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAOA

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008131	primary amine oxidase activity	TAS	--
GO:0050660	flavin adenine dinucleotide binding	--	--
GO:0051378	serotonin binding	--	--

MAOA for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MAOA:

Decreased viability

Animal Models:
Mouse knock-out Maoa^tm1Shih for MAOA
4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Maoa):

behavior/neurological

cardiovascular system

homeostasis/metabolism

nervous system

MAOA for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2

Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2	1.00	Metabolism of serotonin	0.33
melatonin degradation II	1.00	Serotonin clearance from the synaptic cleft	0.33
Amine Oxidase reactions	0.50	phenylalanine degradation IV (mammalian, via side chain)	0.29
tryptophan degradation X (mammalian, via tryptamine)	0.40	putrescine degradation III	0.20

Tyrosine metabolism

	Tyrosine metabolism	1.00			Tyrosine metabolism p.1 (dopamine)	0.28
	Phenylalanine metabolism	0.35			Tyrosine metabolism p.1 (dopamine)	0.28

Enzymatic degradation of dopamine by COMT

	Enzymatic degradation of dopamine by COMT	1.00			Dopamine clearance from the synaptic cleft	0.67
	Enzymatic degradation of Dopamine by monoamine oxidase	1.00			Neurotransmitter Clearance In The Synaptic Cleft	0.29

serotonin degradation

	serotonin degradation	1.00			noradrenaline and adrenaline degradation	0.40
	dopamine degradation	0.58

Transmission across Chemical Synapses

Transmission across Chemical Synapses

1.00

Neuronal System

0.67

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for MAOA

Tyrosine metabolism p.1 (dopamine)

1 GeneGo (Thomson Reuters) Pathway for MAOA

Tyrosine metabolism p.1 (dopamine)

5/11 BioSystems Pathways for MAOA (see all 11)

	SIDS Susceptibility Pathways
	Biogenic Amine Synthesis
	dopamine degradation
	phenylalanine degradation IV (mammalian, via side chain)
	putrescine degradation III

5/15 Reactome Pathways for MAOA (see all 15)

	Enzymatic degradation of dopamine by COMT
	Metabolism of serotonin
	Serotonin clearance from the synaptic cleft
	Enzymatic degradation of Dopamine by monoamine oxidase
	Transmission across Chemical Synapses

1 PharmGKB Pathway for MAOA

Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

5/8 Kegg Pathways (Kegg details for MAOA) (see all 8):

	Glycine, serine and threonine metabolism
	Arginine and proline metabolism
	Histidine metabolism
	Tyrosine metabolism
	Phenylalanine metabolism

MAOA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MAOA

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/79 Interacting proteins for MAOA (P21397^{2, 3} ENSP00000340684⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 79)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
NDRG1	Q92597³, ENSP00000319977⁴	I2D: score=3 STRING: ENSP00000319977
ATP6V1B2	P21281², ENSP00000276390⁴	MINT-4054731 STRING: ENSP00000276390
YWHAB	P31946³	I2D: score=1
A2M	P01023²	MINT-4054731

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006576	cellular biogenic amine metabolic process	TAS	8211186
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0007268	synaptic transmission	TAS	--
GO:0007269	neurotransmitter secretion	TAS	--
GO:0007610	behavior	TAS	8211186

MAOA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

MAOA for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for MAOA available from Tocris Bioscience About this table

Compound	Action	CAS #
Tetrindole mesylate	MAO-A inhibitor	[135991-95-6]
Pirlindole mesylate	MAO-A inhibitor	[60762-57-4]
Harmane	Putative endogenous imidazoline ligand. Also MAO inhibitor	[486-84-0]
Bifemelane hydrochloride	MAO-A and MAO-B inhibitor	[90293-01-9]

10/43 HMDB Compounds for MAOA (see all 43) About this table

Compound	Synonyms	CAS #	PubMed Ids
1-Methylhistamine	1-Methyl-1H-imidazole-4-ethanamine (see all 21)	501-75-7	--
1-Phenylethylamine	a-phenylethylamine (see all 17)	98-84-0	--
3,4-Dihydroxymandelaldehyde	3,4-Dihydroxyphenylglycolaldehyde (see all 4)	13023-73-9	--
3,4-Dihydroxyphenylacetaldehyde	Protocatechuatealdehyde (see all 2)	5707-55-1	--
3-Methoxy-4-hydroxyphenylglycolaldehyde	a,4-dihydroxy-3-methoxy-Benzeneacetaldehyde (see all 4)	17592-23-3	--
3-Methoxytyramine	3-Methoxy-4-hydroxyphenylethyl amine (see all 7)	554-52-9	--
4,6-Dihydroxyquinoline	4,6-Quinolinediol (see all 2)	3517-61-1	--
5-Hydroxyindoleacetaldehyde	(5-hydroxy-1H-indol-3-yl)acetaldehyde (see all 6)	1892-21-3	--
5-Hydroxykynurenamine	5-Hydroxykynuramine (see all 3)	708-23-6	--
5-Methoxytryptamine	2-(5-Methoxy-1H-indol-3-yl)ethanamine (see all 10)	608-07-1	--

10/37 DrugBank Compounds for MAOA (see all 37) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Tranylcypromine	--	155-09-9	target	inhibitor	12504917 8749840 15351283 15276688 10548268 14574774 11752352 20655983 16495723 10027835 15049511 10494892 9829163
Phenelzine	--	51-71-8	target	antagonist	17768678 17912044 14574774 11752352 7092487 19201819 16370964 18700056 9829163
Phenelzine	--	51-71-8	enzyme	substrate	17768678 17912044 14574774 11752352 7092487 19201819 16370964 18700056 9829163 17768678
Pargyline	Benzyl-methyl-2-propinylamin (see all 12)	555-57-7	target	inhibitor	19300583 17823646 9564606 477738 16641841 17715422
Phentermine	(alpha,alpha)-Dimethylphenethylamine (see all 3)	122-09-8	target	antagonist	11911838 11673765 10799660 10231134
Phentermine	(alpha,alpha)-Dimethylphenethylamine (see all 3)	122-09-8	enzyme	inhibitor	11911838 11673765 10799660 10231134 11911838 10799660
Moclobemide	4-Chlor-N-(2-morpholinoethyl)benzamid (see all 11)	71320-77-9	target	inhibitor	1705137 8875133 11752352
Moclobemide	4-Chlor-N-(2-morpholinoethyl)benzamid (see all 11)	71320-77-9	enzyme	inhibitor	1705137 8875133 11752352 11752352
Selegiline	L-Deprenalin (see all 4)	14611-51-9	target	inhibitor	19300583 17823646 16641841 17715422
Almotriptan	--	181183-52-8	enzyme	substrate	12353056 12642466 15762767
Dopamine	Dopamin (see all 6)	51-61-6	enzyme	substrate	15817751 18652859 20869994
Flavin-Adenine Dinucleotide	--	146-14-5	target	--	17139284 17016423 10592235
Furazolidone	Nitrofurazolidone (see all 3)	67-45-8	enzyme	inhibitor	12623758 2032659 10543364

133 Novoseek chemical compound relationships for MAOA gene (see top 10) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
maoa	98.5	1084	17692293 (10), 19224413 (8), 11927135 (8), 15936529 (8) (see all 99)
moclobemide	94.9	153	1546132 (5), 8612391 (3), 9663810 (3), 9174681 (3) (see all 99)
clorgyline	91.8	98	1741773 (4), 9564606 (3), 1893487 (3), 8243537 (2) (see all 54)
brofaromine	90.8	33	8430214 (4), 1967018 (2), 8313400 (2), 8313393 (2) (see all 22)
befloxatone	90.4	36	8613928 (8), 12729662 (3), 7665725 (2), 9728902 (2) (see all 15)
kynuramine	89.7	14	20504539 (1), 8990278 (1), 16139309 (1), 8443155 (1) (see all 12)
toloxatone	88.5	10	1546145 (2), 1705137 (2), 1424410 (2), 8713690 (1) (see all 6)
tyramine	85.5	68	17561096 (4), 8255365 (3), 8695909 (2), 7665725 (2) (see all 37)
pirlindole	83.5	16	8953568 (3), 9564636 (2), 12781338 (2), 9272198 (2) (see all 7)
1-phenylcyclopropylamine	81.4	3	15755651 (1), 15848762 (1)
beta-phenylethylamine	80.7	26	11134050 (2), 1759390 (1), 2293615 (1), 9698044 (1) (see all 19)
lazabemide	80.6	6	1578281 (1), 11481866 (1), 7952273 (1), 9048767 (1) (see all 5)
selegiline	79.2	42	12625864 (4), 9663810 (2), 9564606 (2), 9089426 (1) (see all 22)
dopeg	77.5	9	15801935 (1), 2250565 (1), 9663810 (1), 10333984 (1) (see all 7)
harmine	77	15	12445480 (2), 8990278 (1), 20219660 (1), 10932603 (1) (see all 10)
phenelzine	76.3	4	9829163 (1), 15907150 (1), 1282522 (1)
pargyline	75.3	22	9564606 (3), 7953696 (2), 12777388 (2), 7931312 (1) (see all 12)
1,4-diphenyl-2-butene	74.7	2	15279562 (1), 15710600 (1)
(125i)azipi	74.7	2	10415894 (2)
tranylcypromine	74.3	10	15110846 (1), 9829163 (1), 7972347 (1), 7796873 (1) (see all 7)
3,4-dihydroxyphenylglycolaldehyde	73.4	6	9878889 (2), 11164826 (1), 9518674 (1)
dehydropirlindole	73.1	3	8953568 (2), 9564636 (1)
flavin	72	29	12445480 (2), 10438531 (2), 12781338 (2), 10606764 (1) (see all 15)
isatin	71.6	15	11061215 (2), 7663405 (2), 1510706 (2), 11722560 (1) (see all 10)
benzylamine	70.7	18	10521274 (2), 1741773 (2), 11106506 (2), 9503561 (1) (see all 12)
ladostigil	70.3	2	11889501 (1), 18508575 (1)
rasagiline	69.8	8	15027867 (5), 16366596 (2), 19763773 (1)
dopamine	69.4	186	11400918 (5), 8949927 (3), 16770335 (2), 16674552 (2) (see all 89)
amine	68.8	60	9564606 (4), 9564616 (2), 17142964 (2), 15035812 (2) (see all 36)
tetrindole	68.1	2	12445480 (2)
mhpg	67.7	24	10050962 (2), 8612391 (1), 2293615 (1), 1646924 (1) (see all 11)
norepinephrine	66.5	120	17090537 (2), 11245920 (2), 11545664 (2), 17920180 (2) (see all 72)
n-methylisoquinolinium	64.5	3	7575650 (2)
monamine	64.1	1	16814261 (1)
milacemide	63.6	1	7646533 (1)
5-hydroxyindoleacetic acid	62.5	29	7504085 (5), 14628189 (2), 12629534 (1), 17090537 (1) (see all 10)
1-methyl-4-phenyl-2,3-dihydropyridinium	61.7	2	2344359 (1)
5-hydroxytryptamine	61.5	83	19248248 (3), 19572987 (3), 19423952 (2), 7834200 (2) (see all 27)
mptp	60.9	23	1610807 (3), 8487265 (3), 2358804 (1), 8289189 (1) (see all 11)
2-(2-benzofuranyl)-2-imidazoline	60	2	17480205 (2)
phenethylamine,	59.8	12	11106506 (4), 9503561 (1), 19883764 (1), 11812236 (1) (see all 6)
propargylamine	59.4	1	8469735 (1)
m-tyramine	57.9	1	2293615 (1)
harmaline	56.1	8	8990278 (1), 20219660 (1), 10404423 (1), 12895680 (1) (see all 5)
iproniazid	55.6	1	16002749 (1)
carbon-11	55.6	11	12183115 (1), 18463263 (1), 12729662 (1), 16265597 (1) (see all 6)
pyrazoline	55	3	19091581 (2), 16719786 (1)
oxazolidinone	54.8	6	8613928 (1), 12729662 (1), 15658863 (1), 10482460 (1) (see all 5)
flavin-adenine dinucleotide	54.2	5	11263670 (2), 11331009 (1), 10482460 (1)
isocarboxazid	53.5	1	15784243 (1)
homovanillic acid	53	10	16770335 (1), 10867119 (1), 7527564 (1), 8949927 (1)
harman	51	7	16139309 (1), 17883257 (1), 15582589 (1)
fluvoxamine	49	7	10706994 (2), 10974600 (1), 12886034 (1), 9352586 (1) (see all 6)
maprotiline	46	2	7954483 (1), 7954482 (1)
5-methoxytryptamine	45.8	1	8762094 (1)
1 methyl 4 phenylpyridinium	45.2	4	2244915 (1), 2338548 (1)
fluoxetine	44.6	7	9023788 (1), 10974600 (1), 19077664 (1), 16002749 (1) (see all 6)
catecholamine	44	19	8612391 (2), 17353515 (1), 15817751 (1), 8750929 (1) (see all 14)
ganciclovir	43.8	17	8889283 (2), 9663810 (2), 1646924 (1), 10333984 (1) (see all 11)
almotriptan	43.7	8	12642466 (3), 11422001 (2), 15762767 (1)
imipramine	43.7	7	8301318 (2), 2248074 (1), 9347378 (1), 8570762 (1) (see all 5)
beta-carboline	43.5	11	8990278 (2), 16139309 (1), 17883257 (1), 15582589 (1)
tryptamine	42.8	3	2089079 (1), 8517863 (1), 1741773 (1)
zolmitriptan	41.7	7	9399014 (2), 10553725 (2), 11249525 (1)
paroxetine	41.2	5	10974600 (1), 17192957 (1), 7834200 (1), 9352586 (1) (see all 5)
dopac	40.9	2	8949927 (1)
clomipramine	38.6	1	8848950 (1)
semicarbazide	36.6	2	9564621 (1), 14697793 (1)
levodopa	36.5	11	8949927 (3), 17417741 (2), 7593732 (2), 7830076 (1)
citalopram	36.2	1	11906526 (1)
amitriptyline	35.9	3	2248062 (1), 9352586 (1)
rizatriptan	35.5	3	11249525 (2), 10417495 (1)
sertraline	33.9	4	15547048 (2), 10974600 (1), 9352586 (1)
salsolinol	33.8	2	2296014 (1)
dithionite	33.1	2	12445480 (1), 12781338 (1)
sumatriptan	32	5	8762094 (1), 11249525 (1), 12017403 (1), 19925626 (1)
clonazepam	31.5	2	15907150 (1), 17092192 (1)
bromazepam	30.9	1	17092192 (1)
phenylacetic acid	28.9	1	7918350 (1)
triptan	28.7	4	11460889 (1), 17563839 (1), 11249525 (1)
mianserin	27.7	1	9352586 (1)
indole	27.7	8	7663405 (4), 8517863 (1), 10794685 (1), 18951803 (1)
phenylpropanolamine	27.6	1	14531724 (1)
phentermine	26.8	8	11911838 (4), 10231134 (3)
desipramine	26.1	3	10706994 (2), 9352586 (1)
tele-methylhistamine	25.5	1	17142964 (1)
pyrrole	25.3	3	17256833 (2), 12620068 (1)
pseudoephedrine	24.9	1	14531724 (1)
benzodiazepine	24.8	6	10728803 (1), 14697893 (1), 10206825 (1), 11726089 (1) (see all 6)
semiquinone	24.5	2	12445480 (1), 12781338 (1)
p-chloroamphetamine	23.2	4	7953696 (2), 8100196 (1)
normetanephrine	23.1	3	9564603 (1)
hydrazine	23	7	17142964 (2), 12624735 (1), 18426226 (1)
pregabalin	22.6	2	15907150 (1), 17092192 (1)
linezolid	22.1	9	15521893 (1), 14531724 (1), 15658863 (1), 11336106 (1)
h2o2	18.8	11	7527888 (1), 16049371 (1), 17056035 (1), 17447417 (1) (see all 10)
morpholine	17.9	1	2193111 (1)
gabapentin	16	1	17092192 (1)
auxin	15.6	3	12642466 (1), 19925626 (1)
carbamate	15.5	1	12431053 (1)
epinephrine	15	11	8612391 (1), 18361446 (1), 9131641 (1), 11164826 (1) (see all 6)
d amphetamine	14.1	5	12445480 (2), 2021654 (1), 15035814 (1)
alprazolam	13.1	2	9352586 (1), 17092192 (1)
nicotine	13.1	7	16207390 (2), 19777560 (1), 11768169 (1), 18454435 (1) (see all 5)
benzodiazepines	13	3	15907150 (1), 17092192 (1), 10335676 (1)
cyclopropane	10.9	2	15110846 (1), 15755651 (1)
benzamide	10.4	2	8255982 (1), 7741983 (1)
methylphenidate	9.34	4	19309535 (3), 17572793 (1)
debrisoquine	9.07	3	2338548 (1), 1341965 (1)
coumarins	6.74	3	19267475 (1), 16884303 (1)
histamine	5.15	2	11430877 (1), 17142964 (1)
carbon	3.77	2	7931241 (2)
6-hydroxydopamine	2.28	3	7796873 (1), 17417741 (1)
idazoxan	2.21	3	10415894 (2), 17480205 (1)
coumarin	1.75	2	11123983 (1)
glutamate	1.11	1	11726089 (1)
amphetamine	0.123	4	10231134 (2), 11471875 (1)
gaba	0	3	7750512 (1), 1790159 (1), 7952273 (1)
estrogen	0	22	9698044 (5), 8549621 (3), 7903862 (2), 20439828 (2) (see all 8)
n-ethylmaleimide	0	4	12777388 (3)
ephedrine	0	1	9038453 (1)
choline	0	4	12811639 (2), 7544403 (1)
testosterone	0	16	16728402 (4), 17429405 (3), 1287192 (1), 9120730 (1) (see all 5)
phenylephrine	0	2	8469735 (1), 9038453 (1)
benzyl alcohol	0	4	15130772 (1), 17561096 (1)
methysergide	0	1	2250565 (1)
mdma	0	2	8100196 (1), 15804499 (1)
cysteine	0	5	15848762 (2), 1886775 (1), 12777388 (1)
capsaicin	0	1	8443037 (1)
succinate	0	1	11263670 (1)
dexamethasone	0	8	15946989 (2), 9886786 (1), 16728402 (1), 8584674 (1) (see all 5)
nmda	0	11	16885013 (3), 15671203 (2), 15801935 (1), 9352586 (1)
ascorbic acid	0	4	17723508 (2)

Search CenterWatch for drugs/clinical trials and news about MAOA / AOFA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MAOA gene (2 alternative transcripts):

NM_000240.3 NM_001270458.1

Unigene Cluster for MAOA:

Monoamine oxidase A

Hs.183109 [show with all ESTs]

Unigene Representative Sequence: NM_001270458

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000338702(uc004dfy.3 uc011mkw.2) ENST00000497485 ENST00000490604

ENST00000542639

miRNA Products:		OriGene 3'-UTR Clone: MAOA Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAOA
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate MAOA (see all 13):
		hsa-miR-3163 hsa-miR-495 hsa-miR-767-3p hsa-miR-7-2* hsa-miR-1324 hsa-miR-3065-5p hsa-miR-624* hsa-miR-29b-1*

		SwitchGear 3'UTR luciferase reporter plasmid: MAOA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAOA (see all 4) OriGene shRNA RFP: MAOA OriGene siRNA: MAOA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAOA

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAOA (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAOA OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MAOA (NM_000240)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAOA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAOA

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAOA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MAOA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAOA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAOA

Additional cDNA sequence:

AK123241.1 AK223499.1 AK291769.1 AK293926.1 BC008064.2 BC044787.1 BT006651.1 M68840.1

X17192.1

11 DOTS entries:

DT.95120451 DT.87015236 DT.101981844 DT.100025285 DT.100825058 DT.121278195 DT.100708824 DT.121278204

DT.95120454 DT.100718004 DT.70102839

24/267 AceView cDNA sequences (see all 267):

CD671543 R97085 BG534382 F02245 AW873998 R86250 AA865791 BQ716421

BM923944 BU684121 N30236 BC008064 AW511315 AA995668 AI624415 CB162010

N29331 AW627528 BX952460 AI159812 AI674356 H82430 BQ720697 BM127028

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MAOA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGAAGTTT

About this image

MAOA expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Alveolar type II cells (Derivation of mature...)

Lung

HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)

Adipose

TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)

Bone, Cartilage

HyStem+BMP4-induced E15 cells (HyStem+BMP4 inductio...)

Adipose, Bone, Cartilage

See MAOA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAOA

SOURCE GeneReport for Unigene cluster: Hs.183109

UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397

Tissue specificity: Heart, liver, duodenum, blood vessels and kidney

SABiosciences Expression via Pathway-Focused PCR Arrays including MAOA:

Amino Acid Metabolism II in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAOA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MAOA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAOA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAOA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAOA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MAOA gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MAOA⁶	monoamine oxidase A	73(a)	1 ↔ 1	1(114866376-114910104)
lizard (Anolis carolinensis)	Reptilia	MAOA⁶	--	71(a)	1 ↔ 1	3(135093798-135122255)
zebrafish (Danio rerio)	Actinopterygii	mao⁶ si:ch211-127i16.2⁶	si:ch211-127i16.2	69(a) 33(a)	1 ↔ many possible ortholog	9(34618751-34683759) 10(19461623-19528134)
honey bee (Apis mellifera)	Insecta	--	--	17(a)	possible ortholog	Group16.2(433804-436374)
worm (Caenorhabditis elegans)	Secernentea	amx-2⁶	AMine oXidase family member (amx-2)	13(a)	possible ortholog	I(12759576-12764950)

ENSEMBL Gene Tree for MAOA (if available)
TreeFam Gene Tree for MAOA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MAOA gene

IL4I1² MAOB²

1 SIMAP similar gene for MAOA using alignment to 7 protein entries: AOFA_HUMAN (see all proteins):

MAOB

MAOA for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397

Polymorphism: A polymorphism 1.2 kb upstream of the MAOA coding sequences consists of a 30-bp repeated sequence present

in 3, 3.5, 4, or 5 copies. The polymorphism affect transcriptional activity of the MAOA gene promoter. Alleles with

3.5 or 4 copies of the repeat sequence are transcribed 2 to 10 times more efficiently than those with 3 or 5 copies of

the repeat

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72554632^1,2	C	pathogenic	43591031(+)	`TAATTC/TAGCGG`	4	Q *	stg¹		0	--	--	--	--
rs192395212^1,2		--	43512260(+)	`AGGATC/TGAGGC`	2	--	us2k¹		0	--	--	--	--
rs6651804^1,2	C,	--	43512290(+)	`caGTCA/GGCCTC`	2	--	us2k¹		2		WA CSA	3
rs6651805^1,2	C,	--	43512293(+)	`TCGGCT/CTCAGC`	2	--	us2k¹		2		WA CSA	3
rs4824657^1,2	C,F,A,H,	--	43512302(+)	`GCAGCC/GTTGTC`	2	--	us2k¹		10		NA WA CSA	19
rs190415945^1,2		--	43512369(+)	`TTTTTC/TCTACC`	2	--	us2k¹		0	--	--	--	--
rs111820934^1,2	C,	--	43512512(+)	`ACATTC/TGTCAG`	2	--	us2k¹		1		CSA	1
rs181609653^1,2		--	43512744(+)	`GATTTC/TTTCAT`	2	--	us2k¹		0	--	--	--	--
rs184317279^1,2		--	43512882(+)	`CATATG/TTCTTT`	2	--	us2k¹		0	--	--	--	--
rs189095413^1,2		--	43512904(+)	`AACAAA/GATGTT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MAOA (43515409 - 43606068 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for MAOA
4 CNVs: 83478 73964 96623 73963
Human Gene Mutation Database (HGMD): MAOA

Locus Specific Mutation Databases (LSDB): MAOA

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAOA

DNA2.0 Custom Variant and Variant Library Synthesis for MAOA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MAOA for disorders           About GeneDecksing

OMIM gene information: 309850
OMIM disorders: 300615
UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397

Defects in MAOA are the cause of Brunner syndrome (BRUNS) [MIM:300615]. Brunner syndrome is a form of X-linked

non-dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and

exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have

normal intelligence and behavior

20/111 diseases for MAOA (see all 111): About MalaCards

substance abuse brunner syndrome lesch-nyhan syndrome obsessive-compulsive disorder

post-traumatic stress disorder novelty seeking personality attention deficit hyperactivity disorder severe pre-eclampsia

manic-depressive illness pre-eclampsia antisocial personality disorder borderline personality disorder

relapsing-remitting multiple sclerosis personality disorder generalized anxiety disorder sudden infant death syndrome

anxiety disorder specific phobia social phobia bulimia nervosa

13 diseases from the University of Copenhagen DISEASES database for MAOA:

Parkinson's disease Anxiety disorder Antisocial personality disorder Conduct disorder

Attention deficit hyperactivity disorder Endogenous depression Schizophrenia Toxic encephalopathy

Melancholia Alcohol dependence Avoidant personality disorder Borderline personality disorder

Migraine

10/76 Novoseek disease relationships for MAOA gene (see all 76) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
antisocial behavior	75.8	57	17008143 (4), 18023041 (3), 19120058 (3), 10359483 (2) (see all 20)
borderline mental retardation	74.5	3	8776592 (1), 9326944 (1), 8613523 (1)
antisocial personality disorder	65.4	32	12824808 (5), 17007976 (3), 10049583 (2), 20175604 (2) (see all 10)
major depression	64.7	65	18337637 (4), 10564737 (4), 17884271 (4), 9179504 (3) (see all 28)
aggressive behavior	63	36	15817751 (3), 15211623 (2), 18996506 (2), 17657171 (2) (see all 22)
crisis hypertensive	59.4	7	17554106 (1), 9829163 (1), 14697896 (1), 19527191 (1)
attention-deficit hyperactivity disorder	55.8	15	17230031 (2), 8862874 (1), 12140786 (1), 19309535 (1) (see all 13)
bipolar disorder	53.7	47	10402508 (4), 8776592 (3), 9342194 (3), 16958037 (3) (see all 21)
phobia social	53.6	8	8313403 (2), 10361959 (1), 8619339 (1), 9534836 (1) (see all 5)
parkinson disease	52.5	32	7593732 (3), 17044053 (2), 8358501 (2), 9579294 (2) (see all 22)

Genetic Association Database (GAD): MAOA
Human Genome Epidemiology (HuGE) Navigator: MAOA (290 documents)

Export disorders for MAOA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MAOA gene, integrated from 9 sources (see all 1080):
(articles sorted by number of sources associating them with MAOA)

Utopia: connect your pdf to the dynamic
world of online information

Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B. (PubMed id 16129825)^{1, 2, 9} De Colibus L.... Mattevi A. (2005)
Analysis of monoamine oxidase A (MAOA) promoter polymorphism in Finnish male alcoholics. (PubMed id 11927135)^{1, 4, 9} Saito T....Tiihonen J. (2002)
Structure of human monoamine oxidase A at 2.2-A resolution: the control of opening the entry for substrates/inhibitors. (PubMed id 18391214)^{1, 2, 9} Son S.-Y.... Tsukihara T. (2008)
Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity. (PubMed id 15870836)^{1, 4, 9} Jacob C.P....Lesch K.P. (2005)
Telomeric length varies with age and polymorphisms of the MAOA gene promoter in peripheral blood cells obtained from a community in Taiwan. (PubMed id 15722955)^{1, 4, 9} Lung F.W....Shu B.C. (2005)
Gene-gene interaction between MAOA and COMT in suicidal behavior. (PubMed id 15936529)^{1, 4, 9} De Luca V....Kennedy J.L. (2005)
Association of variations in monoamine oxidases A and B with Parkinson's disease subgroups. (PubMed id 14962671)^{1, 4, 9} Parsian A....Perlmutter J.S. (2004)
Analysis of monoamine oxidase A (MAO-A) promoter polymorphism in male heroin-dependent subjects: behavioural and personality correlates. (PubMed id 15088154)^{1, 4, 9} Gerra G....Donnini C. (2004)
A regulatory monoamine oxidase a promoter polymorphism and personality traits. (PubMed id 12566936)^{1, 4, 9} Garpenstrand H....Jonsson E.G. (2002)
No association of the MAOA gene with alcoholism among Han Chinese males in Taiwan. (PubMed id 11999895)^{1, 4, 9} Lu R.B....Shih J.C. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4128	HGNC: 6833	AceView: MAOA	Ensembl:ENSG00000189221	euGenes: HUgn4128
ECgene: MAOA	Kegg: 4128	H-InvDB: MAOA

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MAOA	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MAOA
Wikipedia	http://en.wikipedia.org/wiki/Monoamine_oxidase

Intellectual Property for MAOA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MAOA gene:
Search GeneIP for patents involving MAOA

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Small Molecules at EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of MAOA
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Kits and Assays available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for MAOA		OriGene shRNA RFP for MAOA
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAOA		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAOA
	OriGene Protein Over-expression Lysate for MAOA		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for MAOA		OriGene 3'-UTR Clone for MAOA
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAOA		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAOA
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MAOA		OriGene Custom Protein Services for MAOA
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAOA
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAOA
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAOA
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAOA
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAOA
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAOA

	GenScript Custom Purified and Recombinant Proteins Services for MAOA		GenScript cDNA clones with any tag delivered in your preferred vector for MAOA
	GenScript Custom Assay Services for MAOA		GenScript Custom Superior Antibodies Services for MAOA
	GenScript Custom overexpressing Cell Line Services for MAOA		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in MAOA promoter
	Search Chromatin IP Primers for MAOA
	RT² qPCR Primer Assay in human, mouse, rat MAOA
	GNC Network for MAOA
	SABiosciences PCR Arrays including human, mouse, rat MAOA

Tocris compounds for MAOA

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	MAOA antibodies
	MAOA proteins
	MAOA lysates

	Antibodies for MAOA
	See all of Abcam's Antibodies, Kits and Proteins for MAOA
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

MAOA Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for MAOA

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAOA

	SwitchGear 3'UTR luciferase reporter plasmids for MAOA
	SwitchGear Promoter luciferase reporter plasmids for MAOA

ThermoFisher Antibodies for MAOA

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAOA

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MAOA gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

MAOA Gene

monoamine oxidase A

Aliases
for MAOA gene

Summaries
for MAOA gene

Genomic Views
for MAOA gene

Proteins
for MAOA gene

Protein Domains /
Families
for MAOA gene

Function
for MAOA gene

Pathways & Interactions
for MAOA gene

Drugs & Compounds
for MAOA gene

Transcripts
for MAOA gene

Expression
for MAOA gene

Orthologs
for MAOA gene

Paralogs
for MAOA gene

Genomic Variants
for MAOA gene

Disorders / Diseases
for MAOA gene

Publications
for MAOA gene

External Searches for MAOA gene

Genome Databases showing MAOA gene

Other Databases showing MAOA gene

Specialized Databases showing MAOA gene

Intellectual Property
for MAOA gene

Products
for MAOA gene

View Random Gene

Dementia
Migraine
Generalized Anxiety Disorder
Serotonin syndrome
Agoraphobia
Anxiety Disorders
Genetic Susceptibility
cognitive disorder
aggressiveness
Personality Disorders
physical abuse
Hypotension Orthostatic
Stress Psychological
Schizophrenia
dysthymia
disability
Cancer
borderline mental retardation
Mood Disorders
Phobia Social
Borderline Personality Disorder
Depressive state
major depressive episode
Epilepsy
Tourette Syndrome
Inflammation
antisocial behavior
Stress Disorders Posttraumatic
Drug Dependence
Chronic Headache
BEHAVIOR ABNORMAL
Bipolar Disorder
psychiatric disorder
Severe pre-eclampsia
prostate cancer
Tumors
Mental Retardation
Depressive disorder
Bulimia Nervosa
Panic Disorder
neuroticism
Necrosis
SMOKING HABIT
Antisocial Personality Disorder
Preeclampsia
Neurofibrillary Tangles
major depression
Neurodegenerative Diseases
Cirrhosis
Neurological Disorders
Parkinson Disease
Panic Attacks
Anorexia Nervosa
clinical depression
Hepatic Encephalopathy
Sexual Abuse
Alzheimers Disease
neurodegeneration
Alcoholism
Effects Cardiovascular
mild mental retardation
Carcinoid
aggressive behavior
CRISIS HYPERTENSIVE
Chronic Fatigue Syndrome
Hypertension Portal
Obsessive-Compulsive Disorder
Pancreatic tumor
OBESITY
attention-deficit hyperactivity disorder
Conduct Disorder
neuron loss
severe mental retardation
Lesch-Nyhan Syndrome
Vitiligo
Psychotic

Advanced Search

Export list of displayed genes

MAOA Gene

monoamine oxidase A

Aliasesfor MAOA gene

Summariesfor MAOA gene

Genomic Viewsfor MAOA gene

Proteinsfor MAOA gene

Protein Domains /Familiesfor MAOA gene

Functionfor MAOA gene

Pathways & Interactionsfor MAOA gene

Drugs & Compoundsfor MAOA gene

Transcriptsfor MAOA gene

Expression for MAOA gene

Orthologsfor MAOA gene

Paralogsfor MAOA gene

Genomic Variantsfor MAOA gene

Disorders / Diseasesfor MAOA gene

Publicationsfor MAOA gene

External Searches for MAOA gene

Genome Databases showing MAOA gene

Other Databases showing MAOA gene

Specialized Databases showing MAOA gene

Intellectual Propertyfor MAOA gene

Productsfor MAOA gene

View Random Gene

Aliases
for MAOA gene

Summaries
for MAOA gene

Genomic Views
for MAOA gene

Proteins
for MAOA gene

Protein Domains /
Families
for MAOA gene

Function
for MAOA gene

Pathways & Interactions
for MAOA gene

Drugs & Compounds
for MAOA gene

Transcripts
for MAOA gene

Expression
for MAOA gene

Orthologs
for MAOA gene

Paralogs
for MAOA gene

Genomic Variants
for MAOA gene

Disorders / Diseases
for MAOA gene

Publications
for MAOA gene

Intellectual Property
for MAOA gene

Products
for MAOA gene