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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAOA Gene

protein-coding   GIFtS: 71
GCID: GC0XP043515

monoamine oxidase A
 Explore 111 diseases affiliated with
MAOA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAOA    

Aliases
for MAOA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Monoamine Oxidase A1 2
Monoamine Oxidase Type A2 3
MAO-A2 3
EC 1.4.3.43 8
Amine Oxidase [Flavin-Containing] A2
EC 1.4.38

External Ids:    HGNC: 68331   Entrez Gene: 41282   Ensembl: ENSG000001892217   OMIM: 3098505   UniProtKB: P213973   

Export aliases for MAOA gene to outside databases

Previous GC identifers: GC0XP041545 GC0XP041794 GC0XP042360 GC0XP042636 GC0XP043271 GC0XP043400 GC0XP041246


Summaries
for MAOA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAOA:
This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative
deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner
syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial
behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. (provided by
RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397
Function: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the
metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA
preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine

summary for MAOA:
Monoamine Oxidases (MAO) catalyze the oxidation of monoamines such as dopamine, serotonin and adrenalin.
They are found bound to the outer membrane of mitochondria in most cell types in the body. Two subtypes of
monoamine oxidase have been identified: MAO-A and MAO-B. Both are found in neurons and astroglia, with MAO-A
also found in the liver, gastrointestinal tract and placenta and MAO-B in blood platelets. Abnormal
regulation of MAOs in the body has been associated with depression, substance abuse, attention deficit
disorder, and irregular sexual maturation.

Gene Wiki entry for MAOA (Monoamine oxidase A)


Genomic Views
for MAOA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_079573.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAOA gene promoter:
         MEF-2A   c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAOA promoter sequence
   Search SABiosciences Chromatin IP Primers for MAOA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAOA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.3   Ensembl cytogenetic band:  Xp11.3   HGNC cytogenetic band: Xp11.4-p11.3

MAOA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAOA gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP043515:  view genomic region     (about GC identifiers)

Start:
 43,515,409 bp from pter      End:
 43,606,068 bp from pter
Size:
 90,660 bases      Orientation:
 plus strand

Proteins
for MAOA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397 (See protein sequence)
Recommended Name: Amine oxidase [flavin-containing] A  
Size: 527 amino acids; 59682 Da
Cofactor: FAD
Subunit: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently
bound flavin. Enzymatically active as monomer
Subcellular location: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side
Mass spectrometry: Mass=60512; Mass_error=6; Method=Electrospray; Range=1-527; Source=PubMed:11812236;
5 PDB 3D structures from and Proteopedia for MAOA:
1H8Q (3D)        2BXR (3D)        2BXS (3D)        2Z5X (3D)        2Z5Y (3D)    
Secondary accessions: B4DF46 Q16426
Alternative splicing: 2 isoforms:  P21397-1   P21397-2   

Explore the universe of human proteins at neXtProt for MAOA: NX_P21397

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P21397

    • 4/22 DME Specific Peptides for MAOA (P21397) (see all 22)
     RQPVGRI  DYNNLWR  ERNLPSV  FPPVWNP 

    MAOA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_000231.1  NP_001257387.1  

    ENSEMBL proteins: 
     ENSP00000340684   ENSP00000440846  
    Reactome Protein details: P21397
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: MAOA
    OriGene Custom Protein Services for MAOA 
    GenScript Custom Purified and Recombinant Proteins Services for MAOA
    Novus Biologicals MAOA Protein
    Novus Biologicals MAOA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MAOA

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005739mitochondrion ----
    GO:0005741mitochondrial outer membrane TAS--
    GO:0016021integral to membrane IEA--


    MAOA for ontologies           About GeneDecksing



    MAOA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MAOA
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 4): MAOA
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    Novus Biologicals MAOA Antibodies
    Abcam antibodies for MAOA 
    Uscn Antibodies for MAOA
    ThermoFisher Antibodies for MAOA

    Assay Products for MAOA: 
    Browse Kits and Assays available from EMD Millipore
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    Browse OriGene Fluorogenic Cell Assay Kits
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    GenScript Custom Assay Services for MAOA
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MAOA

    Protein Domains /
    Families
    for MAOA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAOA for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001613 Flavin_amine_oxidase
     IPR002937 Amino_oxidase

    Graphical View of Domain Structure for InterPro Entry P21397

    ProtoNet protein and cluster: P21397

    1 Blocks protein family: IPB001613 Flavin-containing amine oxidase signature

    UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397
    Similarity: Belongs to the flavin monoamine oxidase family


    Function
    for MAOA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397
    Function: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the
    metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA
    preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine
    Catalytic activity: RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2)

         Genatlas biochemistry entry for MAOA:
    monoamine oxidase A,overexpressed in female panic disorders

    Enzyme Numbers (IUBMB): EC 1.4.3.41 2 EC 1.4.32

    miRNA
    Products:            		miRTarBase miRNAs that target MAOA:
    hsa-mir-22 (MIRT005902)

    OriGene 3'-UTR Clone: MAOA
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAOA
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate MAOA (see all 13):
    hsa-miR-3163 hsa-miR-495 hsa-miR-767-3p hsa-miR-7-2* hsa-miR-1324 hsa-miR-3065-5p hsa-miR-624* hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmid: MAOA 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAOA (see all 4)
    OriGene shRNA RFP: MAOA
    OriGene siRNA: MAOA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAOA

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MAOA

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAOA (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAOA
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MAOA (NM_000240)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAOA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAOA 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MAOA
    Search LifeMap BioReagents cell lines for MAOA

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAOA

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008131primary amine oxidase activity TAS--
    GO:0050660flavin adenine dinucleotide binding ----
    GO:0051378serotonin binding ----


    MAOA for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MAOA:
     Decreased viability 

    Animal Models:
         Mouse knock-out Maoatm1Shih for MAOA
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Maoa):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  nervous system 

    MAOA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MAOA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2
    		Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O21.00
    		Metabolism of serotonin0.33
    		melatonin degradation II1.00
    		Serotonin clearance from the synaptic cleft0.33
    		Amine Oxidase reactions0.50
    		phenylalanine degradation IV (mammalian, via side chain)0.29
    		tryptophan degradation X (mammalian, via tryptamine)0.40
    		putrescine degradation III0.20
    2Tyrosine metabolism
    		Tyrosine metabolism1.00
    		Tyrosine metabolism p.1 (dopamine) 0.28
    		Phenylalanine metabolism0.35
    		Tyrosine metabolism p.1 (dopamine)0.28
    3Enzymatic degradation of dopamine by COMT
    		Enzymatic degradation of dopamine by COMT1.00
    		Dopamine clearance from the synaptic cleft0.67
    		Enzymatic degradation of Dopamine by monoamine oxidase1.00
    		Neurotransmitter Clearance In The Synaptic Cleft0.29
    4serotonin degradation
    		serotonin degradation1.00
    		noradrenaline and adrenaline degradation0.40
    		dopamine degradation0.58
    5Transmission across Chemical Synapses
    		Transmission across Chemical Synapses1.00
    		Neuronal System0.67

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for MAOA
        Tyrosine metabolism p.1 (dopamine)


    1 GeneGo (Thomson Reuters) Pathway for MAOA
        Tyrosine metabolism p.1 (dopamine)

    5/11 BioSystems Pathways for MAOA (see all 11) 
        SIDS Susceptibility Pathways
    Biogenic Amine Synthesis
    dopamine degradation
    phenylalanine degradation IV (mammalian, via side chain)
    putrescine degradation III

    5/15        Reactome Pathways for MAOA (see all 15)
        Enzymatic degradation of dopamine by COMT
    Metabolism of serotonin
    Serotonin clearance from the synaptic cleft
    Enzymatic degradation of Dopamine by monoamine oxidase
    Transmission across Chemical Synapses

    1 PharmGKB Pathway for MAOA
        Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    5/8         Kegg Pathways  (Kegg details for MAOA) (see all 8):
        Glycine, serine and threonine metabolism
    Arginine and proline metabolism
    Histidine metabolism
    Tyrosine metabolism
    Phenylalanine metabolism


    MAOA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAOA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/79 Interacting proteins for MAOA (P213972, 3 ENSP000003406844) via UniProtKB, MINT, STRING, and/or I2D (see all 79)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    NDRG1Q925973, ENSP000003199774I2D: score=3 STRING: ENSP00000319977
    ATP6V1B2P212812, ENSP000002763904MINT-4054731 STRING: ENSP00000276390
    YWHABP319463I2D: score=1 
    A2MP010232MINT-4054731
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006576cellular biogenic amine metabolic process TAS8211186
    GO:0006805xenobiotic metabolic process TAS--
    GO:0007268synaptic transmission TAS--
    GO:0007269neurotransmitter secretion TAS--
    GO:0007610behavior TAS8211186


    MAOA for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAOA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAOA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MAOA available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Tetrindole mesylateMAO-A inhibitor[135991-95-6]
    Pirlindole mesylateMAO-A inhibitor[60762-57-4]
    HarmanePutative endogenous imidazoline ligand. Also MAO inhibitor[486-84-0]
    Bifemelane hydrochlorideMAO-A and MAO-B inhibitor[90293-01-9]

    10/43 HMDB Compounds for MAOA (see all 43)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Methylhistamine1-Methyl-1H-imidazole-4-ethanamine (see all 21)501-75-7--
    1-Phenylethylaminea-phenylethylamine (see all 17)98-84-0--
    3,4-Dihydroxymandelaldehyde3,4-Dihydroxyphenylglycolaldehyde (see all 4)13023-73-9--
    3,4-DihydroxyphenylacetaldehydeProtocatechuatealdehyde (see all 2)5707-55-1--
    3-Methoxy-4-hydroxyphenylglycolaldehydea,4-dihydroxy-3-methoxy-Benzeneacetaldehyde (see all 4)17592-23-3--
    3-Methoxytyramine3-Methoxy-4-hydroxyphenylethyl amine (see all 7)554-52-9--
    4,6-Dihydroxyquinoline4,6-Quinolinediol (see all 2)3517-61-1--
    5-Hydroxyindoleacetaldehyde(5-hydroxy-1H-indol-3-yl)acetaldehyde (see all 6)1892-21-3--
    5-Hydroxykynurenamine5-Hydroxykynuramine (see all 3)708-23-6--
    5-Methoxytryptamine2-(5-Methoxy-1H-indol-3-yl)ethanamine (see all 10)608-07-1--

    10/37 DrugBank Compounds for MAOA (see all 37)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Tranylcypromine-- 155-09-9targetinhibitor12504917 8749840 15351283 15276688 10548268 14574774 11752352 20655983 16495723 10027835 15049511 10494892 9829163
    Phenelzine-- 51-71-8targetantagonist17768678 17912044 14574774 11752352 7092487 19201819 16370964 18700056 9829163
    enzymesubstrate17768678 17912044 14574774 11752352 7092487 19201819 16370964 18700056 9829163 17768678
    PargylineBenzyl-methyl-2-propinylamin (see all 12)555-57-7targetinhibitor19300583 17823646 9564606 477738 16641841 17715422
    Phentermine(alpha,alpha)-Dimethylphenethylamine (see all 3)122-09-8targetantagonist11911838 11673765 10799660 10231134
    enzymeinhibitor11911838 11673765 10799660 10231134 11911838 10799660
    Moclobemide4-Chlor-N-(2-morpholinoethyl)benzamid (see all 11)71320-77-9targetinhibitor1705137 8875133 11752352
    enzymeinhibitor1705137 8875133 11752352 11752352
    SelegilineL-Deprenalin (see all 4)14611-51-9targetinhibitor19300583 17823646 16641841 17715422
    Almotriptan-- 181183-52-8enzymesubstrate12353056 12642466 15762767
    DopamineDopamin (see all 6)51-61-6enzymesubstrate15817751 18652859 20869994
    Flavin-Adenine Dinucleotide-- 146-14-5target--17139284 17016423 10592235
    FurazolidoneNitrofurazolidone (see all 3)67-45-8enzymeinhibitor12623758 2032659 10543364

    10/133 Novoseek chemical compound relationships for MAOA gene (see all 133)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    maoa 98.5 1084 17692293 (10), 19224413 (8), 11927135 (8), 15936529 (8) (see all 99)
    moclobemide 94.9 153 1546132 (5), 8612391 (3), 9663810 (3), 9174681 (3) (see all 99)
    clorgyline 91.8 98 1741773 (4), 9564606 (3), 1893487 (3), 8243537 (2) (see all 54)
    brofaromine 90.8 33 8430214 (4), 1967018 (2), 8313400 (2), 8313393 (2) (see all 22)
    befloxatone 90.4 36 8613928 (8), 12729662 (3), 7665725 (2), 9728902 (2) (see all 15)
    kynuramine 89.7 14 20504539 (1), 8990278 (1), 16139309 (1), 8443155 (1) (see all 12)
    toloxatone 88.5 10 1546145 (2), 1705137 (2), 1424410 (2), 8713690 (1) (see all 6)
    tyramine 85.5 68 17561096 (4), 8255365 (3), 8695909 (2), 7665725 (2) (see all 37)
    pirlindole 83.5 16 8953568 (3), 9564636 (2), 12781338 (2), 9272198 (2) (see all 7)
    1-phenylcyclopropylamine 81.4 3 15755651 (1), 15848762 (1)

    Search CenterWatch for drugs/clinical trials and news about MAOA / AOFA 

    Transcripts
    for MAOA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAOA gene (2 alternative transcripts): 
    NM_000240.3  NM_001270458.1  

    Unigene Cluster for MAOA:

    Monoamine oxidase A
    Hs.183109  [show with all ESTs]
    Unigene Representative Sequence: NM_001270458
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338702(uc004dfy.3 uc011mkw.2) ENST00000497485 ENST00000490604
    ENST00000542639

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MAOA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAOA
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate MAOA (see all 13):
    hsa-miR-3163 hsa-miR-495 hsa-miR-767-3p hsa-miR-7-2* hsa-miR-1324 hsa-miR-3065-5p hsa-miR-624* hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmid: MAOA 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAOA (see all 4)
    OriGene shRNA RFP: MAOA
    OriGene siRNA: MAOA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAOA
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAOA (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAOA
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MAOA (NM_000240)
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MAOA
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAOA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAOA

    Additional cDNA sequence: 

    AK123241.1 AK223499.1 AK291769.1 AK293926.1 BC008064.2 BC044787.1 BT006651.1 M68840.1 
    X17192.1 

    11 DOTS entries:

    DT.95120451  DT.87015236  DT.101981844  DT.100025285  DT.100825058  DT.121278195  DT.100708824  DT.121278204 
    DT.95120454  DT.100718004  DT.70102839 

    267 AceView cDNA sequences (see top 24):

    CD671543 R97085 BG534382 F02245 AW873998 R86250 AA865791 BQ716421 
    BM923944 BU684121 N30236 BC008064 AW511315 AA995668 AI624415 CB162010 
    N29331 AW627528 BX952460 AI159812 AI674356 H82430 BQ720697 BM127028 
    AI076531 AI220677 AI313440 BQ027513 CF527930 R10233 AI335934 CB163302 
    BQ893267 AA376875 AI890731 BQ717463 BF448960 CK818787 AA873246 AI088940 
    AA573451 AW630749 NM_000240 CA444528 BM669916 AA659255 AI915791 CD671544 
    CK429936 CK818786 CB241506 AA420624 CB241628 AA885295 BX104397 BX482553 
    AL701354 BU608860 AK123241 BP352884 AL549863 AI797437 BX339769 BG740300 
    CB128094 CB155013 AU139923 AU140489 CD673624 N62670 AL708544 AL701608 
    AA334728 AU139713 BG705536 AA669731 W37581 CA442512 BG709176 AA514315 
    R25387 AL598711 AW841078 BP382250 AL573895 AL515012 CD245128 BQ721199 
    BX471454 AI076430 BP351231 M78114 BV207305 BQ021942 BX438808 AL571583 
    BM126730 BE176993 AI686884 BI598189 BQ720965 BX506751 BI918813 BT006651 
    X17192 BE272452 H86788 CB999294 AA995194 CD172338 BI765402 AL546100 
    BU752426 CA442505 W37456 M69226 BQ718105 AA370624 M68840 CB306149 
    AA035648 BF445719 R14881 H47910 AL045407 BQ008541 AA369500 BG548472 
    AL598999 CD654144 BX470440 BM923678 AI188313 AA923354 BF002633 BM083532 
    AI057376 BE709374 AI335779 H47909 R97132 CB265884 BE677529 BG436495 
    CF146751 BX501303 BX473179 BF979673 BM016942 AA723979 CD607875 N57029 
    BE176857 AA558669 CD607877 AI128053 CD607879 R82235 BG005660 CD679349 
    CD607887 BM955964 F06002 N91846 BE870338 BG012130 BG720646 R98809 
    BE161822 BX499203 R82187 AA385543 BG564693 BF980315 BI058870 CD607881 
    W31268 BF029258 AW190846 CB268702 AL042858 CB159914 CD607889 AI458107 
    N29336 CF141025 CB148092 BG540523 AW580384 BF367969 AU098656 BG290950 
    AW385159 CB268383 BE567313 BE167781 N80444 AI057372 CD673623 BF986344 
    BP382834 H05883 N57128 CD607883 AI262901 H82693 N57023 AL701405 
    BE833469 AI057254 AW883944 AW273921 AW518785 AA035752 H01420 AA862941 
    CD109257 AA229805 AA558103 CD607885 AI217098 AW466333 AA011096 D58669 
    BE172529 AI831214 BG435284 BG113444 H78551 H83402 BF806681 AA535101 
    AA878660 CD697795 AL524852 H86846 AA376941 BF367941 BI057808 BI057340 
    BQ932761 AA873797 R86249 H48386 H79038 H04908 H01970 AI204657 
    BP334228 BF996146 AA878907 BQ368373 AL515011 H05775 BE162358 R11385 
    BF335274 BP351216 AA627841 BE177037 AA533001 AA011095 R35893 N73914 
    BP334158 R35894 BX330644 

    GeneLoc Exon Structure


    Expression
    for MAOA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAOA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTGAAGTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAOA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Alveolar type II cells (Derivation of mature...)Lung
    HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)Adipose
    TGF?3+BMP7-induced chondrocytes (Chondrogenic HyStem+...)Bone, Cartilage
    HyStem+BMP4-induced E15 cells (HyStem+BMP4 inductio...)Adipose, Bone, Cartilage

    See MAOA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAOA

    SOURCE GeneReport for Unigene cluster: Hs.183109

    UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397
    Tissue specificity: Heart, liver, duodenum, blood vessels and kidney

        SABiosciences Expression via Pathway-Focused PCR Arrays including MAOA: 
              Amino Acid Metabolism II in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAOA
    Browse OriGene validated miRNA SYBR primer pairs
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAOA
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAOA

    Orthologs
    for MAOA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MAOA gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAOA6
    		 monoamine oxidase A
    		 73(a)
    		 1 ↔ 1
    		 1(114866376-114910104)
    lizard
    (Anolis carolinensis)    		 Reptilia MAOA6
    		 --
    		 71(a)
    		 1 ↔ 1
    		 3(135093798-135122255)
    zebrafish
    (Danio rerio)    		 Actinopterygii mao6
    si:ch211-127i16.26
    		 si:ch211-127i16.2
    		 69(a)
    33(a)
    		 1 ↔ many
    possible ortholog
    		 9(34618751-34683759)
    10(19461623-19528134)
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 17(a)
    		 possible ortholog
    		 Group16.2(433804-436374)
    worm
    (Caenorhabditis elegans)    		 Secernentea amx-26
    		 AMine oXidase family member (amx-2)
    		 13(a)
    		 possible ortholog
    		 I(12759576-12764950)


    ENSEMBL Gene Tree for MAOA (if available)
    TreeFam Gene Tree for MAOA (if available) 

    Paralogs
    for MAOA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAOA gene
    IL4I12  MAOB2  
    1 SIMAP similar gene for MAOA using alignment to 7 protein entries:     AOFA_HUMAN (see all proteins):
    MAOB

    MAOA for paralogs           About GeneDecksing



    Genomic Variants
    for MAOA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397
    Polymorphism: A polymorphism 1.2 kb upstream of the MAOA coding sequences consists of a 30-bp repeated sequence present
    in 3, 3.5, 4, or 5 copies. The polymorphism affect transcriptional activity of the MAOA gene promoter. Alleles with
    3.5 or 4 copies of the repeat sequence are transcribed 2 to 10 times more efficiently than those with 3 or 5 copies of
    the repeat


    10/907 NCBI SNPs in MAOA are shown (see all 907)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs725546321,2
    		Cpathogenic43591031(+) TAATTC/TAGCGG 4 Q * stg10--------
    rs1923952121,2
    		--43512260(+) AGGATC/TGAGGC 2 -- us2k10--------
    rs66518041,2
    		C,--43512290(+) caGTCA/GGCCTC 2 -- us2k12Minor allele frequency- G:0.00WA CSA 3
    rs66518051,2
    		C,--43512293(+) TCGGCT/CTCAGC 2 -- us2k12Minor allele frequency- C:0.00WA CSA 3
    rs48246571,2
    		C,F,A,H,--43512302(+) GCAGCC/GTTGTC 2 -- us2k110Minor allele frequency- G:0.32NA WA CSA 19
    rs1904159451,2
    		--43512369(+) TTTTTC/TCTACC 2 -- us2k10--------
    rs1118209341,2
    		C,--43512512(+) ACATTC/TGTCAG 2 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs1816096531,2
    		--43512744(+) GATTTC/TTTCAT 2 -- us2k10--------
    rs1843172791,2
    		--43512882(+) CATATG/TTCTTT 2 -- us2k10--------
    rs1890954131,2
    		--43512904(+) AACAAA/GATGTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAOA (43515409 - 43606068 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for MAOA
         4 CNVs: 83478 73964 96623 73963
    Human Gene Mutation Database (HGMD): MAOA

    Locus Specific Mutation Databases (LSDB): MAOA

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAOA
    DNA2.0 Custom Variant and Variant Library Synthesis for MAOA

    Disorders / Diseases
    for MAOA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAOA for disorders           About GeneDecksing

    OMIM gene information: 309850   
    OMIM disorders: 300615  
    UniProtKB/Swiss-Prot: AOFA_HUMAN, P21397
  • Defects in MAOA are the cause of Brunner syndrome (BRUNS) [MIM:300615]. Brunner syndrome is a form of X-linked
    • non-dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and
    exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have
    normal intelligence and behavior

    20/111 diseases for MAOA (see all 111):    About MalaCards
    substance abuse    brunner syndrome    lesch-nyhan syndrome    obsessive-compulsive disorder
    post-traumatic stress disorder    novelty seeking personality    attention deficit hyperactivity disorder    severe pre-eclampsia
    manic-depressive illness    pre-eclampsia    antisocial personality disorder    borderline personality disorder
    relapsing-remitting multiple sclerosis    personality disorder    generalized anxiety disorder    sudden infant death syndrome
    anxiety disorder    specific phobia    social phobia    bulimia nervosa

    13 diseases from the University of Copenhagen DISEASES database for MAOA:
    Parkinson's disease     Anxiety disorder     Antisocial personality disorder     Conduct disorder
    Attention deficit hyperactivity disorder     Endogenous depression     Schizophrenia     Toxic encephalopathy
    Melancholia     Alcohol dependence     Avoidant personality disorder     Borderline personality disorder
    Migraine

    10/76 Novoseek disease relationships for MAOA gene (see all 76)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    antisocial behavior 75.8 57 17008143 (4), 18023041 (3), 19120058 (3), 10359483 (2) (see all 20)
    borderline mental retardation 74.5 3 8776592 (1), 9326944 (1), 8613523 (1)
    antisocial personality disorder 65.4 32 12824808 (5), 17007976 (3), 10049583 (2), 20175604 (2) (see all 10)
    major depression 64.7 65 18337637 (4), 10564737 (4), 17884271 (4), 9179504 (3) (see all 28)
    aggressive behavior 63 36 15817751 (3), 15211623 (2), 18996506 (2), 17657171 (2) (see all 22)
    crisis hypertensive 59.4 7 17554106 (1), 9829163 (1), 14697896 (1), 19527191 (1)
    attention-deficit hyperactivity disorder 55.8 15 17230031 (2), 8862874 (1), 12140786 (1), 19309535 (1) (see all 13)
    bipolar disorder 53.7 47 10402508 (4), 8776592 (3), 9342194 (3), 16958037 (3) (see all 21)
    phobia social 53.6 8 8313403 (2), 10361959 (1), 8619339 (1), 9534836 (1) (see all 5)
    parkinson disease 52.5 32 7593732 (3), 17044053 (2), 8358501 (2), 9579294 (2) (see all 22)

    Genetic Association Database (GAD): MAOA
    Human Genome Epidemiology (HuGE) Navigator: MAOA (290 documents)

    Export disorders for MAOA gene to outside databases

    Publications
    for MAOA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAOA gene, integrated from 9 sources (see all 1080):
    (articles sorted by number of sources associating them with MAOA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B. (PubMed id 16129825)1, 2, 9 De Colibus L.... Mattevi A. (2005)
    2. Analysis of monoamine oxidase A (MAOA) promoter polymorphism in Finnish male alcoholics. (PubMed id 11927135)1, 4, 9 Saito T....Tiihonen J. (2002)
    3. Structure of human monoamine oxidase A at 2.2-A resolution: the control of opening the entry for substrates/inhibitors. (PubMed id 18391214)1, 2, 9 Son S.-Y.... Tsukihara T. (2008)
    4. Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity. (PubMed id 15870836)1, 4, 9 Jacob C.P....Lesch K.P. (2005)
    5. Telomeric length varies with age and polymorphisms of the MAOA gene promoter in peripheral blood cells obtained from a community in Taiwan. (PubMed id 15722955)1, 4, 9 Lung F.W....Shu B.C. (2005)
    6. Gene-gene interaction between MAOA and COMT in suicidal behavior. (PubMed id 15936529)1, 4, 9 De Luca V....Kennedy J.L. (2005)
    7. Association of variations in monoamine oxidases A and B with Parkinson's disease subgroups. (PubMed id 14962671)1, 4, 9 Parsian A....Perlmutter J.S. (2004)
    8. Analysis of monoamine oxidase A (MAO-A) promoter polymorphism in male heroin-dependent subjects: behavioural and personality correlates. (PubMed id 15088154)1, 4, 9 Gerra G....Donnini C. (2004)
    9. A regulatory monoamine oxidase a promoter polymorphism and personality traits. (PubMed id 12566936)1, 4, 9 Garpenstrand H....Jonsson E.G. (2002)
    10. No association of the MAOA gene with alcoholism among Han Chinese males in Taiwan. (PubMed id 11999895)1, 4, 9 Lu R.B....Shih J.C. (2002)

    External Searches for MAOA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MAOA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4128 HGNC: 6833 AceView: MAOA Ensembl:ENSG00000189221 euGenes: HUgn4128
    ECgene: MAOA Kegg: 4128 H-InvDB: MAOA

    Other Databases showing MAOA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAOA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAOA Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MAOA
    Wikipedia http://en.wikipedia.org/wiki/Monoamine_oxidase

    Intellectual Property
    for MAOA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAOA gene:
    Search GeneIP for patents involving MAOA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MAOA gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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    About This Section

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