Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MAOA Gene

Aliases for MAOA Gene

  • Monoamine Oxidase A 2 3 5
  • Monoamine Oxidase Type A 3 4
  • EC 1.4.3.4 4 61
  • MAO-A 3 4
  • Amine Oxidase [Flavin-Containing] A 3
  • EC 1.4.3 61
  • BRNRS 3

External Ids for MAOA Gene

Previous GeneCards Identifiers for MAOA Gene

  • GC0XP041545
  • GC0XP041794
  • GC0XP042360
  • GC0XP042636
  • GC0XP043271
  • GC0XP043400
  • GC0XP043515
  • GC0XP041246

Summaries for MAOA Gene

Entrez Gene Summary for MAOA Gene

  • This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

GeneCards Summary for MAOA Gene

MAOA (Monoamine Oxidase A) is a Protein Coding gene. Diseases associated with MAOA include Brunner Syndrome and Maoa-Related Behavior Disorders. Among its related pathways are Serotonergic synapse and Histidine metabolism. GO annotations related to this gene include oxidoreductase activity and primary amine oxidase activity. An important paralog of this gene is MAOB.

UniProtKB/Swiss-Prot for MAOA Gene

  • Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Tocris Summary for MAOA Gene

  • Monoamine Oxidases (MAO) catalyze the oxidation of monoamines such as dopamine, serotonin and adrenalin. They are found bound to the outer membrane of mitochondria in most cell types in the body. Two subtypes of MAO have been identified: MAO-A and MAO-B.

Gene Wiki entry for MAOA Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAOA Gene

Genomics for MAOA Gene

Regulatory Elements for MAOA Gene

Enhancers for MAOA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG043642 1.2 FANTOM5 Ensembl ENCODE 51.2 -11.0 -10983 1.9 ZNF316 HMBOX1 NFE2 EMSY MAFK MAOA GC0XM043588
GH0XG043692 1.4 Ensembl ENCODE dbSUPER 43.5 +39.2 39220 2.5 ELF3 FOXA2 ARID4B DMAP1 RAD21 RARA YY1 FOS CREM MIXL1 MAOA GC0XM043837
GH0XG043589 1 Ensembl ENCODE 58.7 -64.5 -64547 2.0 ELF3 SOX13 FOXA2 ARID4B MAX CEBPG RAD21 RARA HOMEZ ZNF652 MAOA GC0XM043588 PIR34051
GH0XG043654 1 ENCODE 55.8 +0.7 671 3.0 ATF1 ARID4B SIN3A BRCA1 YY1 ZNF207 KLF7 SP3 SP5 SREBF1 MAOA GC0XM043837
GH0XG043744 0.9 ENCODE 57.2 +91.7 91658 3.2 ATF1 CBX3 NFRKB ZBTB40 YY1 ZNF766 GATA2 THAP11 HCFC1 ZBTB11 MAOA GC0XM043837
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAOA on UCSC Golden Path with GeneCards custom track

Promoters for MAOA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000246123 1694 4799 ATF1 ARID4B SIN3A BRCA1 YY1 ZNF207 KLF7 SP3 SP5 SREBF1

Genomic Location for MAOA Gene

Chromosome:
X
Start:
43,654,907 bp from pter
End:
43,746,824 bp from pter
Size:
91,918 bases
Orientation:
Plus strand

Genomic View for MAOA Gene

Genes around MAOA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAOA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAOA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAOA Gene

Proteins for MAOA Gene

  • Protein details for MAOA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21397-AOFA_HUMAN
    Recommended name:
    Amine oxidase [flavin-containing] A
    Protein Accession:
    P21397
    Secondary Accessions:
    • B4DF46
    • Q16426

    Protein attributes for MAOA Gene

    Size:
    527 amino acids
    Molecular mass:
    59682 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.

    Three dimensional structures from OCA and Proteopedia for MAOA Gene

    Alternative splice isoforms for MAOA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAOA Gene

Selected DME Specific Peptides for MAOA Gene

P21397:
  • AGERAARE
  • AIPPTLTAKIHFRPELP
  • VIGGGISGLSAAKLL
  • DYNNLWR
  • RVGGRTYT
  • GPTQNRILR
  • DNMGKEIP
  • RQPVGRI
  • WSGYMEGAV
  • PAIMGFILARK
  • LFVNINVTSEPH
  • VSALWFLWYVKQCGGTTRI
  • EPESKDVPA
  • FPPVWNP
  • FAGTETAT
  • VLEARDRVGGRT
  • ERNQLIQRLPMGA
  • PVHYEEKNWC
  • HEVSALWFLWYV
  • CELYAKVLGS
  • ERNLPSV
  • PVGRIFFAG

Post-translational modifications for MAOA Gene

  • Ubiquitination at posLast=469469
  • Modification sites at PhosphoSitePlus

Other Protein References for MAOA Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MAOA Gene

Graphical View of Domain Structure for InterPro Entry

P21397

UniProtKB/Swiss-Prot:

AOFA_HUMAN :
  • Belongs to the flavin monoamine oxidase family.
Family:
  • Belongs to the flavin monoamine oxidase family.
genes like me logo Genes that share domains with MAOA: view

No data available for Gene Families for MAOA Gene

Function for MAOA Gene

Molecular function for MAOA Gene

GENATLAS Biochemistry:
monoamine oxidase A,overexpressed in female panic disorders
UniProtKB/Swiss-Prot CatalyticActivity:
RCH(2)NHR + H(2)O + O(2) = RCHO + RNH(2) + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

Enzyme Numbers (IUBMB) for MAOA Gene

Gene Ontology (GO) - Molecular Function for MAOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008131 primary amine oxidase activity TAS --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with MAOA: view
genes like me logo Genes that share phenotypes with MAOA: view

Human Phenotype Ontology for MAOA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MAOA Gene

MGI Knock Outs for MAOA:

Animal Model Products

miRNA for MAOA Gene

miRTarBase miRNAs that target MAOA

Inhibitory RNA Products

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for MAOA Gene

Localization for MAOA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAOA Gene

Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAOA gene
Compartment Confidence
mitochondrion 5
extracellular 2
nucleus 2
cytosol 2
plasma membrane 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MAOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 20833797
GO:0005741 mitochondrial outer membrane TAS 24252804
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MAOA: view

Pathways & Interactions for MAOA Gene

genes like me logo Genes that share pathways with MAOA: view

Gene Ontology (GO) - Biological Process for MAOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006576 cellular biogenic amine metabolic process TAS 8211186
GO:0006584 catecholamine metabolic process IEA --
GO:0042133 neurotransmitter metabolic process TAS --
GO:0042135 neurotransmitter catabolic process IEA --
GO:0042420 dopamine catabolic process TAS 24252804
genes like me logo Genes that share ontologies with MAOA: view

No data available for SIGNOR curated interactions for MAOA Gene

Drugs & Compounds for MAOA Gene

(120) Drugs for MAOA Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Moclobemide Approved Pharma inhibitor, Target, Enzyme Reversible MAO-A inhibitor 7
Isocarboxazid Approved Pharma inhibitor, Target 2
Phenelzine Approved Pharma inhibitor, Target, Enzyme, antagonist, substrate 7
Selegiline Approved, Investigational, Vet_approved Pharma inhibitor, Target 27
Tranylcypromine Approved Pharma inhibitor, Target 24

(90) Additional Compounds for MAOA Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Methoxytryptamine
  • 2-(5-Methoxy-1H-indol-3-yl)ethanamine
  • 2-(5-Methoxyindol-3-yl)ethylamine
  • 3-(2-Aminoethyl)-5-methoxyindole
  • 5-Mot
  • 5MOT
608-07-1
Normetanephrine
  • (+/-)-alpha-(aminomethyl)-4-hydroxy-3-methoxy-Benzenemethanol
  • (+/-)-Normetanephrine
  • 3-Methoxy-Noradrenaline
  • 3-O-Methyl-Noradrenaline
  • 4-(2-Amino-1-hydroxyethyl)-2-methoxyphenol
97-31-4
1-Methylhistamine
  • 1-Methyl-1H-imidazole-4-ethanamine
  • 1-Methyl-4-(2-aminoethyl)imidazole
  • 1-Methyl-4-(b-aminoethyl)imidazole
  • 1-Methyl-4-(beta-aminoethyl)imidazole
  • 1-Methyl-4-histamine
501-75-7
1-Phenylethylamine
  • (1-Aminoethyl)benzene
  • (S)-(-)-a-Methyl-benzylamine
  • 1-Amino-1-phenylethane
  • 1-Fenylethylamin
  • 1-Phenyl-1-ethanamine
98-84-0
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
  • 3,4-Dihydroxyphenylglycolic aldehyde
  • a,3,4-Trihydroxy-Benzeneacetaldehyde
  • alpha,3,4-Trihydroxy-Benzeneacetaldehyde
13023-73-9

(5) Tocris Compounds for MAOA Gene

Compound Action Cas Number
(R)-(-)-Deprenyl hydrochloride MAO-B inhibitor 14611-52-0
Bifemelane hydrochloride MAO-A and MAO-B inhibitor 62232-46-6
Lazabemide hydrochloride Selective MAO-B inhibitor 103878-83-7
Moclobemide Reversible MAO-A inhibitor 71320-77-9
Rasagiline mesylate Selective, irreversible MAO-B inhibitor 161735-79-1

(13) ApexBio Compounds for MAOA Gene

Compound Action Cas Number
2-BFI hydrochloride
BU 224 hydrochloride Antagonist of I2 Imidazoline receptor,potent and selective 205437-64-5
BU 226 hydrochloride Ligand at I2 imidazoline sites,high affinity and selectivity 1186195-56-1
BU 239 hydrochloride Ligand of imidazoline I2 receptor,potent and selective 1217041-98-9
Moclobemide (Ro 111163) Reversible inhibitor of MAO-A 71320-77-9
Paeonol MAO inhibitor;multi-functional phenolic compound 552-41-0
Pirlindole mesylate 207572-66-5
Procarbazine HCl Antineoplastic chemotherapy drug 366-70-1
RS 45041-190 hydrochloride 204274-74-8
Sennoside A Irritant laxative;mild MAO inhibitor 81-27-6
Tetrindole mesylate 170964-68-8
Tranylcypromine (2-PCPA) HCl Monoamine oxidase inhibitor 4548-34-9
Tranylcypromine hydrochloride 1986-47-6
genes like me logo Genes that share compounds with MAOA: view

Drug Products

Transcripts for MAOA Gene

Unigene Clusters for MAOA Gene

Monoamine oxidase A:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAOA Gene

No ASD Table

Relevant External Links for MAOA Gene

GeneLoc Exon Structure for
MAOA
ECgene alternative splicing isoforms for
MAOA

Expression for MAOA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MAOA Gene

Protein differential expression in normal tissues from HIPED for MAOA Gene

This gene is overexpressed in Placenta (12.0), Nasal epithelium (9.2), Nasopharynx (7.5), and Adipocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAOA Gene



Protein tissue co-expression partners for MAOA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MAOA Gene:

MAOA

SOURCE GeneReport for Unigene cluster for MAOA Gene:

Hs.183109

mRNA Expression by UniProt/SwissProt for MAOA Gene:

P21397-AOFA_HUMAN
Tissue specificity: Heart, liver, duodenum, blood vessels and kidney.

Evidence on tissue expression from TISSUES for MAOA Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Intestine(2.9)
  • Adrenal gland(2.7)
  • Heart(2.7)
  • Kidney(2.7)
  • Blood(2.5)
  • Lung(2.4)
  • Thyroid gland(2.4)
  • Muscle(2.3)
  • Pancreas(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MAOA Gene

Germ Layers:
  • ectoderm
Systems:
  • nervous
Organs:
Head and neck:
  • brain
  • head
genes like me logo Genes that share expression patterns with MAOA: view

Primer Products

No data available for mRNA differential expression in normal tissues for MAOA Gene

Orthologs for MAOA Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAOA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAOA 35
  • 99 (a)
OneToOne
LOC743285 34
  • 98.8 (n)
dog
(Canis familiaris)
Mammalia MAOA 34 35
  • 86.65 (n)
mouse
(Mus musculus)
Mammalia Maoa 34 16 35
  • 85.19 (n)
cow
(Bos Taurus)
Mammalia MAOA 34 35
  • 84.95 (n)
rat
(Rattus norvegicus)
Mammalia Maoa 34
  • 84.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MAOA 35
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAOA 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAOA 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAOA 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495198 34
  • 68.62 (n)
zebrafish
(Danio rerio)
Actinopterygii mao 35
  • 69 (a)
OneToMany
Species where no ortholog for MAOA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAOA Gene

ENSEMBL:
Gene Tree for MAOA (if available)
TreeFam:
Gene Tree for MAOA (if available)

Paralogs for MAOA Gene

Paralogs for MAOA Gene

(1) SIMAP similar genes for MAOA Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MAOA: view

Variants for MAOA Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MAOA Gene

AOFA_HUMAN-P21397
A polymorphism 1.2 kb upstream of the MAOA coding sequences consists of a 30-bp repeated sequence present in 3, 3.5, 4, or 5 copies. The polymorphism affect transcriptional activity of the MAOA gene promoter. Alleles with 3.5 or 4 copies of the repeat sequence are transcribed 2 to 10 times more efficiently than those with 3 or 5 copies of the repeat.

Sequence variations from dbSNP and Humsavar for MAOA Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_036545 A breast cancer sample
rs587777457 Pathogenic 43,731,695(+) TTAGT(G/T)CAAAT reference, missense
rs72554632 Pathogenic 43,731,784(+) TAATT(C/T)AGCGG reference, stop-gained
rs796065311 Pathogenic 43,731,344(+) CAGTC(-/T)AAGTG reference, frameshift-variant
rs796065312 Pathogenic 43,683,572(+) AAGCT(C/T)GGGAC reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MAOA Gene

Variant ID Type Subtype PubMed ID
esv21483 CNV gain 19812545
nsv1078108 CNV duplication 25765185
nsv1150180 CNV duplication 26484159
nsv517873 CNV gain 19592680

Variation tolerance for MAOA Gene

Residual Variation Intolerance Score: 18.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAOA Gene

Human Gene Mutation Database (HGMD)
MAOA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAOA

Disorders for MAOA Gene

MalaCards: The human disease database

(52) MalaCards diseases for MAOA Gene - From: OMIM, ClinVar, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
brunner syndrome
  • monoamine oxidase a deficiency
maoa-related behavior disorders
antisocial personality disorder
  • asocial personality
social phobia
  • phobia social
conduct disorder
- elite association - COSMIC cancer census association via MalaCards
Search MAOA in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

AOFA_HUMAN
  • Brunner syndrome (BRNRS) [MIM:300615]: A form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. {ECO:0000269 PubMed:8211186}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MAOA

Genetic Association Database (GAD)
MAOA
Human Genome Epidemiology (HuGE) Navigator
MAOA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAOA
genes like me logo Genes that share disorders with MAOA: view

No data available for Genatlas for MAOA Gene

Publications for MAOA Gene

  1. A non-additive interaction of a functional MAO-A VNTR and testosterone predicts antisocial behavior. (PMID: 17429405) SjAPberg R.L. … Goldman D. (Neuropsychopharmacology 2008) 3 22 25 46 64
  2. Association of VNTR polymorphisms in the MAOA promoter and DRD4 exon 3 with heroin dependence in male Chinese addicts. (PMID: 20218801) Chien C.C. … Lung F.W. (World J. Biol. Psychiatry 2010) 3 22 46 64
  3. Gene-gene interaction between COMT and MAOA potentially predicts the intelligence of attention-deficit hyperactivity disorder boys in China. (PMID: 19941049) Qian Q.J. … Faraone S.V. (Behav. Genet. 2010) 3 22 46 64
  4. Meta-analysis of the association between the monoamine oxidase-A gene and mood disorders. (PMID: 20010318) Fan M. … Zhang J. (Psychiatr. Genet. 2010) 3 22 46 64
  5. The interleukin-6, serotonin transporter, and monoamine oxidase A genes and endurance performance during the South African Ironman Triathlon. (PMID: 19935847) de Milander L. … Collins M. (Appl Physiol Nutr Metab 2009) 3 22 46 64

Products for MAOA Gene

Sources for MAOA Gene

Content
Loading form....