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Aliases for MANSC4 Gene

Aliases for MANSC4 Gene

  • MANSC Domain Containing 4 2 3 5

External Ids for MANSC4 Gene

Previous GeneCards Identifiers for MANSC4 Gene

  • GC12M027917

Summaries for MANSC4 Gene

GeneCards Summary for MANSC4 Gene

MANSC4 (MANSC Domain Containing 4) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MANSC4 Gene

Genomics for MANSC4 Gene

Genomic Location for MANSC4 Gene

Chromosome:
12
Start:
27,762,641 bp from pter
End:
27,773,083 bp from pter
Size:
10,443 bases
Orientation:
Minus strand

Genomic View for MANSC4 Gene

Genes around MANSC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MANSC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MANSC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MANSC4 Gene

No data available for Regulatory Elements for MANSC4 Gene

Proteins for MANSC4 Gene

  • Protein details for MANSC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHS7-MANS4_HUMAN
    Recommended name:
    MANSC domain-containing protein 4
    Protein Accession:
    A6NHS7

    Protein attributes for MANSC4 Gene

    Size:
    340 amino acids
    Molecular mass:
    37879 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MANSC4 Gene

Proteomics data for MANSC4 Gene at MOPED

Post-translational modifications for MANSC4 Gene

  • Glycosylation at Asn 118, Asn 187, and Asn 260
  • Modification sites at PhosphoSitePlus

Other Protein References for MANSC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MANSC4 Gene

Domains & Families for MANSC4 Gene

Protein Domains for MANSC4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MANSC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NHS7

UniProtKB/Swiss-Prot:

MANS4_HUMAN :
  • Contains 1 MANSC domain.
Domain:
  • Contains 1 MANSC domain.
genes like me logo Genes that share domains with MANSC4: view

No data available for Gene Families for MANSC4 Gene

Function for MANSC4 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MANSC4 Gene

Localization for MANSC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MANSC4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MANSC4 Gene COMPARTMENTS Subcellular localization image for MANSC4 gene
Compartment Confidence
extracellular 2
lysosome 1
peroxisome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for MANSC4 Gene

Pathways & Interactions for MANSC4 Gene

SuperPathways for MANSC4 Gene

No Data Available

Interacting Proteins for MANSC4 Gene

Gene Ontology (GO) - Biological Process for MANSC4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MANSC4 Gene

Drugs & Compounds for MANSC4 Gene

No Compound Related Data Available

Transcripts for MANSC4 Gene

mRNA/cDNA for MANSC4 Gene

(4) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MANSC4 Gene

MANSC domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MANSC4 Gene

No ASD Table

Relevant External Links for MANSC4 Gene

GeneLoc Exon Structure for
MANSC4
ECgene alternative splicing isoforms for
MANSC4

Expression for MANSC4 Gene

mRNA expression in normal human tissues for MANSC4 Gene

mRNA differential expression in normal tissues according to GTEx for MANSC4 Gene

This gene is overexpressed in Testis (x7.4), Brain - Cerebellar Hemisphere (x5.5), and Brain - Cerebellum (x5.4).

Protein differential expression in normal tissues from HIPED for MANSC4 Gene

This gene is overexpressed in Placenta (11.6), Stomach (8.6), and Lung (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MANSC4 Gene



SOURCE GeneReport for Unigene cluster for MANSC4 Gene Hs.202178

genes like me logo Genes that share expression patterns with MANSC4: view

Protein tissue co-expression partners for MANSC4 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MANSC4 Gene

Orthologs for MANSC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MANSC4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MANSC4 35
  • 86.63 (n)
  • 82.72 (a)
MANSC4 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MANSC4 35
  • 87.14 (n)
  • 83.98 (a)
MANSC4 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mansc4 35
  • 71.85 (n)
  • 64.33 (a)
Mansc4 16
Mansc4 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MANSC4 35
  • 99.41 (n)
  • 99.12 (a)
MANSC4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mansc4 35
  • 70.56 (n)
  • 62.46 (a)
oppossum
(Monodelphis domestica)
Mammalia MANSC4 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves MANSC4 35
  • 60.71 (n)
  • 49.22 (a)
MANSC4 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MANSC4 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mansc4 35
  • 48.57 (n)
  • 39.86 (a)
Species with no ortholog for MANSC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MANSC4 Gene

ENSEMBL:
Gene Tree for MANSC4 (if available)
TreeFam:
Gene Tree for MANSC4 (if available)

Paralogs for MANSC4 Gene

No data available for Paralogs for MANSC4 Gene

Variants for MANSC4 Gene

Sequence variations from dbSNP and Humsavar for MANSC4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2881579 -- 27,769,035(+) CTGCT(G/T)CTGTG intron-variant
rs2113867 -- 27,774,022(+) acacg(G/T)ctgta upstream-variant-2KB
rs4931397 -- 27,762,376(+) TGGCT(C/G)TGTTG downstream-variant-500B
rs4931405 -- 27,763,811(+) CTGCA(A/G)CCTCT intron-variant
rs4931407 -- 27,764,602(+) cctcc(A/G)acaca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MANSC4 Gene

Variant ID Type Subtype PubMed ID
esv2745664 CNV Deletion 23290073
esv2668845 CNV Deletion 23128226

Variation tolerance for MANSC4 Gene

Gene Damage Index Score: 5.27; 70.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MANSC4 Gene

HapMap Linkage Disequilibrium report
MANSC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MANSC4 Gene

Disorders for MANSC4 Gene

Relevant External Links for MANSC4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MANSC4

No disorders were found for MANSC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MANSC4 Gene

Publications for MANSC4 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 67

Products for MANSC4 Gene

Sources for MANSC4 Gene

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