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Aliases for MANF Gene

Aliases for MANF Gene

  • Mesencephalic Astrocyte-Derived Neurotrophic Factor 2 3
  • ARMET 3 4 6
  • ARP 3 4 6
  • Arginine-Rich, Mutated In Early Stage Tumors 2 3
  • Arginine-Rich Protein 4
  • Protein ARMET 4

External Ids for MANF Gene

Previous Symbols for MANF Gene

  • ARMET

Summaries for MANF Gene

Entrez Gene Summary for MANF Gene

  • The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]

GeneCards Summary for MANF Gene

MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor) is a Protein Coding gene. Diseases associated with MANF include pancreatic cancer and esophageal cancer. GO annotations related to this gene include growth factor activity. An important paralog of this gene is CDNF.

UniProtKB/Swiss-Prot for MANF Gene

  • Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.

Gene Wiki entry for MANF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MANF Gene

Genomics for MANF Gene

Genomic Location for MANF Gene

Start:
51,385,047 bp from pter
End:
51,389,397 bp from pter
Size:
4,351 bases
Orientation:
Plus strand

Genomic View for MANF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MANF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MANF Gene

No data available for Regulatory Elements for MANF Gene

Proteins for MANF Gene

  • Protein details for MANF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55145-MANF_HUMAN
    Recommended name:
    Mesencephalic astrocyte-derived neurotrophic factor
    Protein Accession:
    P55145
    Secondary Accessions:
    • Q14CX4
    • Q86U67
    • Q96IS4

    Protein attributes for MANF Gene

    Size:
    182 amino acids
    Molecular mass:
    20700 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB08753.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI13589.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI13591.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MANF Gene

neXtProt entry for MANF Gene

Proteomics data for MANF Gene at MOPED

Post-translational modifications for MANF Gene

Other Protein References for MANF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MANF Gene

Domains for MANF Gene

Protein Domains for MANF Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MANF_HUMAN
Domain:
  • The N-terminal region may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response.:
    • P55145
Family:
  • Belongs to the ARMET family.:
    • P55145
genes like me logo Genes that share domains with MANF: view

No data available for Gene Families for MANF Gene

Function for MANF Gene

Molecular function for MANF Gene

UniProtKB/Swiss-Prot Function: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.
UniProtKB/Swiss-Prot Induction: By endoplasmic reticulum stress.

Gene Ontology (GO) - Molecular Function for MANF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MANF: view

miRNA for MANF Gene

miRTarBase miRNAs that target MANF

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MANF Gene

Localization for MANF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MANF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MANF Gene COMPARTMENTS Subcellular localization image for MANF gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
mitochondrion 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MANF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005634 nucleus IDA 21630459
GO:0005783 endoplasmic reticulum IEA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with MANF: view

Pathways for MANF Gene

SuperPathways for MANF Gene

No Data Available

Interacting Proteins for MANF Gene

Selected Interacting proteins: P55145-MANF_HUMAN for MANF Gene via I2D

Gene Ontology (GO) - Biological Process for MANF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure IEA --
GO:0006986 response to unfolded protein IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MANF: view

No data available for Pathways by source for MANF Gene

Compounds for MANF Gene

(8) Novoseek inferred chemical compound relationships for MANF Gene

Compound -log(P) Hits PubMed IDs
arginine 76.2 52
citrulline 74.5 12
serine 70.8 44
protamine 58.7 5
lysine 47 10
genes like me logo Genes that share compounds with MANF: view

Transcripts for MANF Gene

mRNA/cDNA for MANF Gene

Unigene Clusters for MANF Gene

Mesencephalic astrocyte-derived neurotrophic factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MANF Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
SP1: -
SP2:

Relevant External Links for MANF Gene

GeneLoc Exon Structure for
MANF
ECgene alternative splicing isoforms for
MANF

Expression for MANF Gene

mRNA expression in normal human tissues for MANF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MANF Gene

This gene is overexpressed in Liver (4.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MANF Gene

SOURCE GeneReport for Unigene cluster for MANF Gene Hs.436446

genes like me logo Genes that share expressions with MANF: view

Orthologs for MANF Gene

This gene was present in the common ancestor of animals.

Orthologs for MANF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MANF 36
  • 99.45 (n)
  • 98.9 (a)
MANF 37
  • 73 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MANF 36
  • 93.11 (n)
  • 95.53 (a)
MANF 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MANF 36
  • 92.92 (n)
  • 94.41 (a)
MANF 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Manf 36
  • 91.62 (n)
  • 97.77 (a)
Manf 16
Manf 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 84 (a)
OneToMany
-- 37
  • 84 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MANF 37
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves MANF 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MANF 37
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3135 36
tropical clawed frog
(Silurana tropicalis)
Amphibia manf 36
  • 72.25 (n)
  • 76.3 (a)
Str.2611 36
zebrafish
(Danio rerio)
Actinopterygii Dr.14931 36
manf 36
  • 67.23 (n)
  • 69.27 (a)
manf 37
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003016 36
  • 57.14 (n)
  • 54.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta Manf 36
  • 55.56 (n)
  • 51.23 (a)
Manf 37
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y54G2A.23 36
  • 55.21 (n)
  • 50 (a)
Y54G2A.23 37
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9334 37
  • 48 (a)
OneToMany
Species with no ortholog for MANF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MANF Gene

ENSEMBL:
Gene Tree for MANF (if available)
TreeFam:
Gene Tree for MANF (if available)

Paralogs for MANF Gene

Paralogs for MANF Gene

Selected SIMAP similar genes for MANF Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MANF: view

Variants for MANF Gene

Sequence variations from dbSNP and Humsavar for MANF Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1370124 -- 51,384,757(-) ACGGA(C/T)CCAAC upstream-variant-2KB
rs2217938 -- 51,388,243(-) CGTAC(C/T)ATGTC intron-variant
rs2304512 -- 51,388,050(-) TCAAT(A/G)AGGCC intron-variant
rs3050033 -- 51,388,656(+) GCCTC(-/TG)TCCCT intron-variant
rs9841963 -- 51,385,657(+) TTGAG(A/G)CTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MANF Gene

Variant ID Type Subtype PubMed ID
nsv876779 CNV Loss 21882294

Relevant External Links for MANF Gene

HapMap Linkage Disequilibrium report
MANF

Disorders for MANF Gene

(5) Novoseek inferred disease relationships for MANF Gene

Disease -log(P) Hits PubMed IDs
rheumatoid arthritis 12.7 1
carcinoma renal cell 12.1 1
carcinoma squamous cell 5.72 1
cancer 3.14 2
tumors 0 2
genes like me logo Genes that share disorders with MANF: view

No data available for UniProtKB/Swiss-Prot for MANF Gene

Publications for MANF Gene

  1. MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons. (PMID: 12794311) Petrova P. … Commissiong J.W. (J. Mol. Neurosci. 2003) 2 3 4 23
  2. Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck. (PMID: 8971156) Shridhar R. … Smith D.I. (Cancer Res. 1996) 3 4 23
  3. Mutations in the arginine-rich protein gene (ARP) in pancreatic cancer. (PMID: 9174057) Shridhar V. … Smith D.I. (Oncogene 1997) 3 4 23
  4. A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas. (PMID: 8649854) Shridhar V. … Smith D.I. (Oncogene 1996) 3 4 23
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4

Products for MANF Gene

Sources for MANF Gene

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