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MANF Gene

protein-coding   GIFtS: 52
GCID: GC03P051399

Mesencephalic Astrocyte-Derived Neurotrophic Factor

(Previous names: arginine-rich, mutated in early stage tumors)
(Previous symbol: ARMET)
  See MANF-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mesencephalic Astrocyte-Derived Neurotrophic Factor1 2
ARMET1 2 3 5
ARP2 3 5
Arginine-Rich, Mutated In Early Stage Tumors1 2
Arginine-Rich Protein3
Protein ARMET3

External Ids:    HGNC: 154611   Entrez Gene: 78732   Ensembl: ENSG000001450507   OMIM: 6019165   UniProtKB: P551453   

Export aliases for MANF gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MANF Gene:
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted.
Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell
proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich
region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract.
The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the
previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these
polymorphisms were later shown to exist in normal tissues and are thus not tumor-related. (provided by RefSeq,
Jun 2010)

GeneCards Summary for MANF Gene:
MANF (mesencephalic astrocyte-derived neurotrophic factor) is a protein-coding gene. Diseases associated with MANF include pancreatic cancer, and squamous cell carcinoma of the head and neck. GO annotations related to this gene include growth factor activity. An important paralog of this gene is CDNF.

UniProtKB/Swiss-Prot: MANF_HUMAN, P55145
Function: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic
transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked,
GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation
and endoplasmic reticulum (ER) stress-induced cell death

Gene Wiki entry for MANF (ARMET) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Search for regulatory transcription factor binding sites for MANF
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMANF promoter sequence
   Search Chromatin IP Primers for MANF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MANF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21.1

MANF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MANF gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P051399:  view genomic region     (about GC identifiers)

Start:
51,422,478 bp from pter      End:
51,426,828 bp from pter
Size:
4,351 bases      Orientation:
plus strand

1 alternative location:
Chr3+,NW_003315910 6,584-10,720     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MANF_HUMAN, P55145 (See protein sequence)
Recommended Name: Mesencephalic astrocyte-derived neurotrophic factor precursor  
Size: 182 amino acids; 20700 Da
Caution: Was originally (PubMed:8649854, PubMed:8971156 and PubMed:9174057) thought to be much longer and included
an arginine-rich region thought to be the target of cancer-causing mutations. All these mutations are in what is
now thought to be the 5'-UTR of the mRNA
Caution: It is uncertain whether Met-1 or Met-4 is the initiator
Sequence caution: Sequence=AAB08753.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAI13589.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAI13591.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for MANF:
2KVD (3D)        2KVE (3D)        2W51 (3D)    
Secondary accessions: Q14CX4 Q86U67 Q96IS4

Explore the universe of human proteins at neXtProt for MANF: NX_P55145

Explore proteomics data for MANF at MOPED

Post-translational modifications: 

  • May contain sialic acid residues1
  • Ubiquitination2 at Lys94
  • Modification sites at PhosphoSitePlus

  • See MANF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006001.3  
    ENSEMBL proteins: 
     ENSP00000432799   ENSP00000405280  

    MANF Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for MANF
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    Novus Biologicals MANF Proteins
    Novus Biologicals MANF Lysates
    Sino Biological Recombinant Protein for MANF
    Sino Biological Cell Lysate for MANF
    ProSpec Recombinant Protein for MANF
    Cloud-Clone Corp. Proteins for MANF

     
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    antibodies-online proteins for MANF (21 products) 

     
    antibodies-online peptides for MANF

    MANF Antibody Products:

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    antibodies-online antibodies for MANF (50 products) 

    MANF Assay Products:

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    antibodies-online kits for MANF (13 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR019345 Armet_prot
     IPR011001 Saposin-like

    Graphical View of Domain Structure for InterPro Entry P55145

    ProtoNet protein and cluster: P55145

    UniProtKB/Swiss-Prot: MANF_HUMAN, P55145
    Domain: The N-terminal region may be responsible for neurotrophic activity while the C-terminal region may play a
    role in the ER stress response
    Similarity: Belongs to the ARMET family


    Find genes that share domains with MANF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MANF_HUMAN, P55145
    Function: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic
    transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked,
    GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation
    and endoplasmic reticulum (ER) stress-induced cell death
    Induction: By endoplasmic reticulum stress

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0008083growth factor activity IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with MANF           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MANF

    miRNA
    Products:
        
    miRTarBase miRNAs that target MANF:
    hsa-mir-192-5p (MIRT026482), hsa-mir-26b-5p (MIRT050039), hsa-mir-215-5p (MIRT024847)

    Block miRNA regulation of human, mouse, rat MANF using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate MANF:
    hsa-miR-520d-5p hsa-miR-605 hsa-miR-524-5p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidMANF 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MANF
    Predesigned siRNA for gene silencing in human, mouse, rat MANF

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MANF (NM_006010)
    Sino Biological Human cDNA Clone for MANF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MANF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MANF

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MANF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MANF_HUMAN, P55145: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum2
    mitochondrion2
    nucleus2
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005615extracellular space IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with MANF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including MANF: 
              Unfolded Protein Response in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MANF

    3 Interacting proteins for MANF (P551453) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3GL3Q999633I2D: score=5 
    ZFR2Q9UPR63I2D: score=2 
    IKBKEQ141643I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002014vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure IEA--
    GO:0006986response to unfolded protein IEA--
    GO:0008150biological_process ND--

    Find genes that share ontologies with MANF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MANF

    8 Novoseek inferred chemical compound relationships for MANF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 76.2 68 8390981 (3), 2243097 (2), 8525706 (2), 15210328 (2) (see all 46)
    citrulline 74.5 12 18923650 (1), 15854045 (1), 14579251 (1), 15555572 (1) (see all 12)
    serine 70.8 51 15010457 (2), 15501179 (2), 15210328 (2), 12628928 (1) (see all 41)
    protamine 58.7 6 8390981 (2), 1370607 (1), 2081589 (1), 7765714 (1)
    lysine 47 13 11496758 (2), 8390981 (1), 20455659 (1), 18348515 (1) (see all 9)
    proline 46.3 8 8325374 (2), 8576182 (1), 8798599 (1), 7921540 (1) (see all 6)
    calcium 0 2 12392711 (1), 17851584 (1)
    glutamate 0 1 12216496 (1)



    Find genes that share compounds with MANF           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MANF gene: 
    NM_006010.4  

    Unigene Cluster for MANF:

    Mesencephalic astrocyte-derived neurotrophic factor
    Hs.436446  [show with all ESTs]
    Unigene Representative Sequence: BM916000
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528157(uc003dbc.3) ENST00000446668 ENST00000470900 ENST00000482262

    miRNA
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    Block miRNA regulation of human, mouse, rat MANF using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate MANF:
    hsa-miR-520d-5p hsa-miR-605 hsa-miR-524-5p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidMANF 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat MANF
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    GenScript: all cDNA clones in your preferred vector: MANF (NM_006010)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MANF
    Primer
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    OriGene qPCR primer pairs and template standards for MANF
    OriGene qSTAR qPCR primer pairs in human, mouse for MANF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MANF
      QuantiTect SYBR Green Assays in human, mouse, rat MANF
      QuantiFast Probe-based Assays in human, mouse, rat MANF

    Additional mRNA sequence: 

    AK292243.1 BC007282.1 BC113588.1 BC113590.1 BT007110.1 M83751.1 

    8 DOTS entries:

    DT.417163  DT.101983789  DT.91964159  DT.100789418  DT.91644036  DT.91756086  DT.120864260  DT.91932689 

    Selected AceView cDNA sequences (see all 359):

    BU180390 BI962721 BU736869 CF529879 BM808359 CA946734 BQ007592 BM068803 
    CA950198 BM713497 BM790467 AV706527 AA083956 CD364840 BI789224 BM809540 
    AI032929 BU944621 BU541674 BQ028733 AI936471 BM989639 BU542099 AI140352 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MANF    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
    SP1:                    -               
    SP2:                                    


    ECgene alternative splicing isoforms for MANF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MANF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGGATTCC
    MANF Expression
    About this image


    MANF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Testis (Reproductive System)
    MANF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MANF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436446
        Pathway & Disease-focused RT2 Profiler PCR Array including MANF: 
              Unfolded Protein Response in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MANF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MANF gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Manf1 , 5 mesencephalic astrocyte-derived neurotrophic factor1, 5 91.62(n)1
    97.77(a)1
      9 (57.98 cM)5
    748401  NM_029103.31  NP_083379.21 
     1068383125 
    chicken
    (Gallus gallus)
    Aves MANF6
    mesencephalic astrocyte-derived neurotrophic facto...
    72(a)
    1 ↔ 1
    12(2209956-2213573)
    lizard
    (Anolis carolinensis)
    Reptilia MANF6
    mesencephalic astrocyte-derived neurotrophic facto...
    76(a)
    1 ↔ 1
    2(152083937-152095093)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.31352 Xenopus laevis, Similar to arginine-rich, mutated in more 77.62(n)    BC043846.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.149312 Transcribed sequence with weak similarity to protein more 76.39(n)    BM775555.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Manf1 Mesencephalic astrocyte-derived neurotrophic factor 55.56(n)
    51.23(a)
      41983  NM_058097.5  NP_477445.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y54G2A.231 Y54G2A.23 55.21(n)
    50(a)
      177074  NM_067872.5  NP_500273.2 


    ENSEMBL Gene Tree for MANF (if available)
    TreeFam Gene Tree for MANF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MANF gene
    CDNF2  
    1 SIMAP similar gene for MANF using alignment to 2 protein entries:     MANF_HUMAN (see all proteins):
    CDNF

    Find genes that share paralogs with MANF           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MANF (see all 93)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1923583061,2
    --51356200(+) ACCTCA/GAAGAC 2 K E mis10--------
    rs1997216511,2
    C--51356213(+) AGATGA/TCACAT 2 D V mis10--------
    rs2003458701,2
    C--51356222(+) ATTCTC/TACCAG 2 S L mis11Minor allele frequency- T:0.00EU 569
    rs1137245051,2
    C--51356290(+) GGTTGG/TTAAGT 1 -- spd10--------
    rs1833593141,2
    --51356310(+) TCCTCC/TCCAAC 1 -- int10--------
    rs1880566771,2
    --51356394(+) AAGCCA/GGCTAC 1 -- int10--------
    rs1913709721,2
    --51356439(+) CTTCTA/GTGTCC 1 -- int10--------
    rs772241541,2
    F--51356546(+) GGAAAG/TAAGTG 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1499962591,2
    --51356576(+) ATGCAA/GTGTCT 1 -- int10--------
    rs1442637841,2
    --51356666(+) TGGGGC/TAAGAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for MANF (51422478 - 51426828 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MANF:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876779CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MANF
    DNA2.0 Custom Variant and Variant Library Synthesis for MANF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601916    OMIM disorders: --

    2 diseases for MANF:    
    About MalaCards
    pancreatic cancer    squamous cell carcinoma of the head and neck


    Find genes that share disorders with MANF           About GenesLikeMe

    5 Novoseek inferred disease relationships for MANF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 12.7 1 18923650 (1)
    carcinoma renal cell 12.1 1 9230196 (1)
    carcinoma squamous cell 5.72 1 1370607 (1)
    cancer 3.14 3 9174057 (1), 10767373 (1)
    tumors 0 2 9174057 (1), 9230196 (1)


    Export disorders for MANF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MANF gene, integrated from 10 sources (see all 117):
    (articles sorted by number of sources associating them with MANF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons. (PubMed id 12794311)1, 2, 3, 9 Petrova P....Commissiong J.W. (J. Mol. Neurosci. 2003)
    2. Mutations in the arginine-rich protein gene (ARP) in pancreatic cancer. (PubMed id 9174057)1, 2, 9 Shridhar V....Smith D.I. (Oncogene 1997)
    3. A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas. (PubMed id 8649854)1, 2, 9 Shridhar V.... Smith D.I. (Oncogene 1996)
    4. Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck. (PubMed id 8971156)1, 2, 9 Shridhar R.... Smith D.I. (Cancer Res. 1996)
    5. The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional. (PubMed id 19258449)1, 2 Parkash V.... Goldman A. (Protein Eng. Des. Sel. 2009)
    6. Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death. (PubMed id 18561914)1, 2 Apostolou A.... Fang S. (Exp. Cell Res. 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    9. Polymorphic variation of the ARP gene on 3p21 in Japanese esophageal cancer patients. (PubMed id 10767373)1, 9 Tanaka H....Ishizaki K. (Oncol. Rep. 2000)
    10. Normal polymorphism in the incomplete trinucleotide repeat of the arginine-rich protein gene. (PubMed id 9230196)1, 9 Evron E....Sidransky D. (Cancer Res. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7873 HGNC: 15461 AceView: ARMET Ensembl:ENSG00000145050 euGenes: HUgn7873
    ECgene: MANF H-InvDB: MANF

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MANF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MANF gene:
    Search GeneIP for patents involving MANF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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