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Aliases for MANF Gene

Aliases for MANF Gene

  • Mesencephalic Astrocyte Derived Neurotrophic Factor 2 3 5
  • Mesencephalic Astrocyte-Derived Neurotrophic Factor 2 3
  • Arginine-Rich, Mutated In Early Stage Tumors 2 3
  • ARMET 3 4
  • ARP 3 4
  • Arginine-Rich Protein 4
  • Protein ARMET 4

External Ids for MANF Gene

Previous HGNC Symbols for MANF Gene

  • ARMET

Previous GeneCards Identifiers for MANF Gene

  • GC03P051399

Summaries for MANF Gene

Entrez Gene Summary for MANF Gene

  • The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]

GeneCards Summary for MANF Gene

MANF (Mesencephalic Astrocyte Derived Neurotrophic Factor) is a Protein Coding gene. Diseases associated with MANF include Metaphyseal Chondrodysplasia, Schmid Type. Among its related pathways are Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include poly(A) RNA binding and growth factor activity. An important paralog of this gene is CDNF.

UniProtKB/Swiss-Prot for MANF Gene

  • Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.

Gene Wiki entry for MANF Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MANF Gene

Genomics for MANF Gene

Regulatory Elements for MANF Gene

Enhancers for MANF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G050598 2.5 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10.7 -778.6 -778561 15.0 MLX CREB3L1 AGO1 ZFP64 DMAP1 YBX1 YY1 ZNF143 ZNF263 SP3 TMEM115 HEMK1 RAD54L2 C3orf18 SEMA3F-AS1 DOCK3 MANF GMPPB NAT6 TRAIP
GH03G050616 2 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -760.0 -760048 18.0 HDGF PKNOX1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 DOCK3 HEMK1 MAPKAPK3 C3orf18 RAD54L2 MANF GNAI2 LSMEM2 HYAL1 RASSF1
GH03G050614 1.1 ENCODE dbSUPER 10.7 -770.8 -770803 0.2 HDGF CTCF ZSCAN4 DNMT3B RAD21 ZNF766 POLR2A ZBTB48 ZNF143 SMC3 DOCK3 C3orf18 HEMK1 MANF CISH LINC02019
GH03G051383 1.4 ENCODE dbSUPER 0.7 +3.2 3155 9.5 HDGF PKNOX1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 RRP9 RAD54L2 TEX264 GRM2 CACNA2D2 GPR62 PCBP4 MANF PIR60056
GH03G051339 1.4 FANTOM5 Ensembl ENCODE 0.3 -44.5 -44525 2.9 GTF2F1 TBP TAF1 JUN MAX RFX5 TEAD3 FOSL1 ZFHX2 POLR2A TEX264 WDR82 RAD54L2 PIR61668 MANF
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MANF on UCSC Golden Path with GeneCards custom track

Promoters for MANF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152419 153 2401 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF143 FOS

Genomic Location for MANF Gene

Chromosome:
3
Start:
51,385,047 bp from pter
End:
51,389,397 bp from pter
Size:
4,351 bases
Orientation:
Plus strand

Genomic View for MANF Gene

Genes around MANF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MANF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MANF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MANF Gene

Proteins for MANF Gene

  • Protein details for MANF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55145-MANF_HUMAN
    Recommended name:
    Mesencephalic astrocyte-derived neurotrophic factor
    Protein Accession:
    P55145
    Secondary Accessions:
    • Q14CX4
    • Q86U67
    • Q96IS4

    Protein attributes for MANF Gene

    Size:
    182 amino acids
    Molecular mass:
    20700 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB08753.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI13589.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI13591.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MANF Gene

neXtProt entry for MANF Gene

Post-translational modifications for MANF Gene

Other Protein References for MANF Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MANF

No data available for DME Specific Peptides for MANF Gene

Domains & Families for MANF Gene

Protein Domains for MANF Gene

Suggested Antigen Peptide Sequences for MANF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55145

UniProtKB/Swiss-Prot:

MANF_HUMAN :
  • The N-terminal region may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response.
  • Belongs to the ARMET family.
Domain:
  • The N-terminal region may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response.
Family:
  • Belongs to the ARMET family.
genes like me logo Genes that share domains with MANF: view

No data available for Gene Families for MANF Gene

Function for MANF Gene

Molecular function for MANF Gene

UniProtKB/Swiss-Prot Function:
Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.
UniProtKB/Swiss-Prot Induction:
By endoplasmic reticulum stress.

Gene Ontology (GO) - Molecular Function for MANF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with MANF: view
genes like me logo Genes that share phenotypes with MANF: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MANF

CRISPR Products

miRNA for MANF Gene

miRTarBase miRNAs that target MANF

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MANF

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MANF Gene

Localization for MANF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MANF Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MANF gene
Compartment Confidence
extracellular 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for MANF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005634 nucleus IDA 21630459
GO:0005783 endoplasmic reticulum IBA,IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MANF: view

Pathways & Interactions for MANF Gene

genes like me logo Genes that share pathways with MANF: view

Gene Ontology (GO) - Biological Process for MANF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0006986 response to unfolded protein IEA --
GO:0008150 biological_process ND --
GO:0031175 neuron projection development IBA --
GO:0071542 dopaminergic neuron differentiation IBA --
genes like me logo Genes that share ontologies with MANF: view

No data available for SIGNOR curated interactions for MANF Gene

Drugs & Compounds for MANF Gene

(6) Drugs for MANF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MANF Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MANF: view

Transcripts for MANF Gene

Unigene Clusters for MANF Gene

Mesencephalic astrocyte-derived neurotrophic factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MANF

Alternative Splicing Database (ASD) splice patterns (SP) for MANF Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
SP1: -
SP2:

Relevant External Links for MANF Gene

GeneLoc Exon Structure for
MANF
ECgene alternative splicing isoforms for
MANF

Expression for MANF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MANF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MANF Gene

This gene is overexpressed in Liver (x4.3).

Protein differential expression in normal tissues from HIPED for MANF Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.0) and Oral epithelium (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MANF Gene



Protein tissue co-expression partners for MANF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MANF Gene:

MANF

SOURCE GeneReport for Unigene cluster for MANF Gene:

Hs.436446

Evidence on tissue expression from TISSUES for MANF Gene

  • Liver(4.5)
  • Eye(4.4)
  • Intestine(4.4)
  • Blood(4.3)
  • Pancreas(3.6)
  • Nervous system(3.2)
  • Skin(3)
  • Heart(2.8)
  • Kidney(2.4)
  • Muscle(2.3)
  • Spleen(2.3)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with MANF: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MANF Gene

Orthologs for MANF Gene

This gene was present in the common ancestor of animals.

Orthologs for MANF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MANF 34 35
  • 99.45 (n)
cow
(Bos Taurus)
Mammalia MANF 34 35
  • 93.11 (n)
dog
(Canis familiaris)
Mammalia MANF 34 35
  • 92.92 (n)
mouse
(Mus musculus)
Mammalia Manf 34 16 35
  • 91.62 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 84 (a)
OneToMany
-- 35
  • 84 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MANF 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves MANF 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MANF 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia manf 34
  • 72.25 (n)
Str.2611 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.3135 34
zebrafish
(Danio rerio)
Actinopterygii manf 34 35
  • 67.23 (n)
Dr.14931 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003016 34
  • 57.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta Manf 34 35
  • 55.56 (n)
worm
(Caenorhabditis elegans)
Secernentea Y54G2A.23 34 35
  • 55.21 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9334 35
  • 48 (a)
OneToMany
Species where no ortholog for MANF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MANF Gene

ENSEMBL:
Gene Tree for MANF (if available)
TreeFam:
Gene Tree for MANF (if available)

Paralogs for MANF Gene

Paralogs for MANF Gene

(1) SIMAP similar genes for MANF Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MANF: view

Variants for MANF Gene

Sequence variations from dbSNP and Humsavar for MANF Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1001527198 -- 51,385,791(+) TGTCT(G/T)TTGGG intron-variant
rs1001581439 -- 51,386,006(+) TTGAT(C/G)CCCTG intron-variant
rs1003256690 -- 51,387,629(+) ATCTC(A/C)AAACA intron-variant
rs1003615233 -- 51,387,293(+) CTACT(A/G)AAAAA intron-variant
rs1004328391 -- 51,383,985(+) AAAAT(G/T)ATCTT upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MANF Gene

Variant ID Type Subtype PubMed ID
dgv8321n54 CNV loss 21841781
nsv590276 CNV loss 21841781
nsv590277 CNV loss 21841781

Variation tolerance for MANF Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MANF Gene

Human Gene Mutation Database (HGMD)
MANF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MANF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MANF Gene

Disorders for MANF Gene

MalaCards: The human disease database

(1) MalaCards diseases for MANF Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
metaphyseal chondrodysplasia, schmid type
  • corneal dystrophy, subepithelial mucinous
- elite association - COSMIC cancer census association via MalaCards
Search MANF in MalaCards View complete list of genes associated with diseases

Relevant External Links for MANF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MANF
genes like me logo Genes that share disorders with MANF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MANF Gene

Publications for MANF Gene

  1. MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons. (PMID: 12794311) Petrova P. … Commissiong J.W. (J. Mol. Neurosci. 2003) 2 3 4 22 64
  2. Mutations in the arginine-rich protein gene (ARP) in pancreatic cancer. (PMID: 9174057) Shridhar V. … Smith D.I. (Oncogene 1997) 3 4 22 64
  3. A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas. (PMID: 8649854) Shridhar V. … Smith D.I. (Oncogene 1996) 3 4 22 64
  4. Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck. (PMID: 8971156) Shridhar R. … Smith D.I. (Cancer Res. 1996) 3 4 22 64
  5. The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional. (PMID: 19258449) Parkash V. … Goldman A. (Protein Eng. Des. Sel. 2009) 3 4 64

Products for MANF Gene

  • Addgene plasmids for MANF

Sources for MANF Gene

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