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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MANF Gene

protein-coding   GIFtS: 52
GCID: GC03P051399

Mesencephalic Astrocyte-Derived Neurotrophic Factor

(Previous names: arginine-rich, mutated in early stage tumors)
(Previous symbol: ARMET)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mesencephalic Astrocyte-Derived Neurotrophic Factor1 2
ARMET1 2 3 5
ARP2 3 5
Arginine-Rich, Mutated In Early Stage Tumors1 2
Arginine-Rich Protein3
Protein ARMET3

External Ids:    HGNC: 154611   Entrez Gene: 78732   Ensembl: ENSG000001450507   OMIM: 6019165   UniProtKB: P551453   

Export aliases for MANF gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MANF Gene:
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted.
Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell
proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich
region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract.
The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the
previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors; however, these
polymorphisms were later shown to exist in normal tissues and are thus not tumor-related. (provided by RefSeq,
Jun 2010)

GeneCards Summary for MANF Gene: 
MANF (mesencephalic astrocyte-derived neurotrophic factor) is a protein-coding gene. Diseases associated with MANF include cytomegalovirus infection, and squamous cell carcinoma of the head and neck. GO annotations related to this gene include growth factor activity and molecular_function. An important paralog of this gene is CDNF.

UniProtKB/Swiss-Prot: MANF_HUMAN, P55145
Function: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic
transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked,
GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation
and endoplasmic reticulum (ER) stress-induced cell death

Gene Wiki entry for MANF (ARMET) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MANF
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMANF promoter sequence
   Search SABiosciences Chromatin IP Primers for MANF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MANF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21.1

MANF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MANF gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P051399:  view genomic region     (about GC identifiers)

Start:
51,422,478 bp from pter      End:
51,426,828 bp from pter
Size:
4,351 bases      Orientation:
plus strand

1 alternative location:
Chr3+,NW_003315910 6,584-10,720     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MANF_HUMAN, P55145 (See protein sequence)
Recommended Name: Mesencephalic astrocyte-derived neurotrophic factor precursor  
Size: 182 amino acids; 20700 Da
Subcellular location: Secreted
Caution: Was originally (PubMed:8649854, PubMed:8971156 and PubMed:9174057) thought to be much longer and included
an arginine-rich region thought to be the target of cancer-causing mutations. All these mutations are in what is
now thought to be the 5'-UTR of the mRNA
Caution: It is uncertain whether Met-1 or Met-4 is the initiator
Sequence caution: Sequence=AAB08753.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAI13589.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAI13591.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for MANF:
2KVD (3D)        2KVE (3D)        2W51 (3D)    
Secondary accessions: Q14CX4 Q86U67 Q96IS4

Explore the universe of human proteins at neXtProt for MANF: NX_P55145

Explore proteomics data for MANF at MOPED 

Post-translational modifications:

  • UniProtKB: May contain sialic acid residues
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P55145

  • MANF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MANF Protein Expression
    REFSEQ proteins: NP_006001.3  
    ENSEMBL proteins: 
     ENSP00000432799   ENSP00000405280  

    Human Recombinant Protein Products for MANF: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for MANF
    OriGene MassSpec for MANF 
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    Novus Biologicals MANF Proteins
    Novus Biologicals MANF Lysates
    Sino Biological Recombinant Protein for MANF
    Sino Biological Cell Lysate for MANF 
    ProSpec Recombinant Protein for MANF
    Cloud-Clone Corp. Proteins for MANF 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005615extracellular space IEA--
    GO:0048471perinuclear region of cytoplasm IEA--

    MANF for ontologies           About GeneDecksing



    MANF Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MANF
    R&D Systems Antibodies for MANF
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    Novus Biologicals MANF Antibodies
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    Cloud-Clone Corp. Antibodies for MANF 
    ThermoFisher Antibodies for MANF
    LSBio Antibodies in human, mouse, rat for MANF 

    Assay Products for MANF: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MANF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MANF 
    Cloud-Clone Corp. CLIAs for MANF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR019345 Armet_prot
     IPR011001 Saposin-like

    Graphical View of Domain Structure for InterPro Entry P55145

    ProtoNet protein and cluster: P55145

    UniProtKB/Swiss-Prot: MANF_HUMAN, P55145
    Domain: The N-terminal region may be responsible for neurotrophic activity while the C-terminal region may play a
    role in the ER stress response
    Similarity: Belongs to the ARMET family


    MANF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MANF_HUMAN, P55145
    Function: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic
    transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked,
    GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation
    and endoplasmic reticulum (ER) stress-induced cell death
    Induction: By endoplasmic reticulum stress

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0008083growth factor activity IEA--
         
    MANF for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MANF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MANF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MANF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MANF 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MANF
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate MANF:
    hsa-miR-520d-5p hsa-miR-605 hsa-miR-524-5p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidMANF 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Sirion Biotech Customized adenovirus for overexpression of MANF

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MANF (see all 7)
    OriGene ORF clones in mouse, rat for MANF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MANF (NM_006010)
    Sino Biological Human cDNA Clone for MANF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MANF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MANF
    Sirion Biotech Customized lentivirus for stable overexpression of MANF 
                         Customized lentivirus expression plasmids for stable overexpression of MANF 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MANF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MANF

    3 Interacting proteins for MANF (P551453) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3GL3Q999633I2D: score=5 
    ZFR2Q9UPR63I2D: score=2 
    IKBKEQ141643I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002014vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure IEA--
    GO:0006986response to unfolded protein IEA--
    GO:0008150biological_process ND--

    MANF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MANF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MANF

    8 Novoseek inferred chemical compound relationships for MANF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 76.2 68 8390981 (3), 2243097 (2), 8525706 (2), 15210328 (2) (see all 46)
    citrulline 74.5 12 18923650 (1), 15854045 (1), 14579251 (1), 15555572 (1) (see all 12)
    serine 70.8 51 15010457 (2), 15501179 (2), 15210328 (2), 12628928 (1) (see all 41)
    protamine 58.7 6 8390981 (2), 1370607 (1), 2081589 (1), 7765714 (1)
    lysine 47 13 11496758 (2), 8390981 (1), 20455659 (1), 18348515 (1) (see all 9)
    proline 46.3 8 8325374 (2), 8576182 (1), 8798599 (1), 7921540 (1) (see all 6)
    calcium 0 2 12392711 (1), 17851584 (1)
    glutamate 0 1 12216496 (1)

    Search CenterWatch for drugs/clinical trials and news about MANF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MANF gene: 
    NM_006010.4  

    Unigene Cluster for MANF:

    Mesencephalic astrocyte-derived neurotrophic factor
    Hs.436446  [show with all ESTs]
    Unigene Representative Sequence: BM916000
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528157(uc003dbc.3) ENST00000446668 ENST00000470900 ENST00000482262


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MANF
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate MANF:
    hsa-miR-520d-5p hsa-miR-605 hsa-miR-524-5p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidMANF 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MANF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MANF
    Clone
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    OriGene clones in human, mouse for MANF (see all 7)
    OriGene ORF clones in mouse, rat for MANF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MANF (NM_006010)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MANF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MANF
    Sirion Biotech Customized lentivirus for stable overexpression of MANF 
                         Customized lentivirus expression plasmids for stable overexpression of MANF 
    Primer
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    OriGene qPCR primer pairs and template standards for MANF
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MANF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MANF

    Additional mRNA sequence: 

    AK292243.1 BC007282.1 BC113588.1 BC113590.1 BT007110.1 M83751.1 

    8 DOTS entries:

    DT.417163  DT.101983789  DT.91964159  DT.100789418  DT.91644036  DT.91756086  DT.120864260  DT.91932689 

    24/359 AceView cDNA sequences (see all 359):

    BE395150 CB529516 BM914705 BM142133 BM023535 BQ924909 BM550833 CA946734 
    BE257691 CK819860 BI003060 BU739527 BM704917 BM068803 AA416623 BM555391 
    BM713497 BU077534 AI929047 CF529588 BM875378 BU736869 BM142042 BM790467 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MANF    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
    SP1:                    -               
    SP2:                                    


    ECgene alternative splicing isoforms for MANF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MANF expression in normal human tissues (normalized intensities)      MANF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGGGATTCC
    MANF Expression
    About this image


    MANF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Extraembryonic Tissues)    fully expand to see all 2 entries
             plasma cells   
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Umbilical Cord (Extraembryonic Tissues)
             cord blood   
     
     Eye (Sensory Organs)
             Retina

    See MANF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MANF

    SOURCE GeneReport for Unigene cluster: Hs.436446
        SABiosciences Expression via Pathway-Focused PCR Array including MANF: 
              Unfolded Protein Response in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MANF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MANF gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Manf1 , 5 mesencephalic astrocyte-derived neurotrophic factor1, 5 91.62(n)1
    97.77(a)1
      9 (57.98 cM)5
    748401  NM_029103.31  NP_083379.21 
     1068383125 
    chicken
    (Gallus gallus)
    Aves MANF6
    mesencephalic astrocyte-derived neurotrophic facto...
    75(a)
    1 ↔ 1
    12(2209956-2213573)
    lizard
    (Anolis carolinensis)
    Reptilia MANF6
    Uncharacterized protein
    78(a)
    1 ↔ 1
    2(152083937-152095093)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.31352 Xenopus laevis, Similar to arginine-rich, mutated in more 77.62(n)    BC043846.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.149312 Transcribed sequence with weak similarity to protein more 76.39(n)    BM775555.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Manf1 Mesencephalic astrocyte-derived neurotrophic factor 57.56(n)
    55.33(a)
      41983  NM_058097.4  NP_477445.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y54G2A.231 Protein Y54G2A.23 55.14(n)
    50.31(a)
      177074  NM_067872.4  NP_500273.2 


    ENSEMBL Gene Tree for MANF (if available)
    TreeFam Gene Tree for MANF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MANF gene
    CDNF2  
    1 SIMAP similar gene for MANF using alignment to 2 protein entries:     MANF_HUMAN (see all proteins):
    CDNF

    MANF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/93 SNPs in MANF are shown (see all 93)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1923583061,2
    --51356200(+) ACCTCA/GAAGAC 2 K E mis10--------
    rs1997216511,2
    C--51356213(+) AGATGA/TCACAT 2 D V mis10--------
    rs2003458701,2
    C--51356222(+) ATTCTC/TACCAG 2 S L mis11Minor allele frequency- T:0.00EU 569
    rs1137245051,2
    C--51356290(+) GGTTGG/TTAAGT 1 -- spd10--------
    rs1833593141,2
    --51356310(+) TCCTCC/TCCAAC 1 -- int10--------
    rs1880566771,2
    --51356394(+) AAGCCA/GGCTAC 1 -- int10--------
    rs1913709721,2
    --51356439(+) CTTCTA/GTGTCC 1 -- int10--------
    rs772241541,2
    F--51356546(+) GGAAAG/TAAGTG 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1499962591,2
    --51356576(+) ATGCAA/GTGTCT 1 -- int10--------
    rs1442637841,2
    --51356666(+) TGGGGC/TAAGAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for MANF (51422478 - 51426828 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MANF:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv876779CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MANF
    DNA2.0 Custom Variant and Variant Library Synthesis for MANF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601916    OMIM disorders: --

    20/26 diseases for MANF (see all 26):    About MalaCards
    cytomegalovirus infection    squamous cell carcinoma of the head and neck    tremor    essential tremor
    growth hormone deficiency    esophageal cancer    brain injury    cleft lip
    glaucoma    rheumatoid arthritis    periodontitis    renal cell carcinoma
    parkinson's disease    esophagitis    arthritis    squamous cell carcinoma
    pancreatic cancer    alcoholism    retinitis    pancreatitis


    MANF for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for MANF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 12.7 1 18923650 (1)
    carcinoma renal cell 12.1 1 9230196 (1)
    carcinoma squamous cell 5.72 1 1370607 (1)
    cancer 3.14 3 9174057 (1), 10767373 (1)
    tumors 0 2 9174057 (1), 9230196 (1)


    Export disorders for MANF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MANF gene, integrated from 9 sources (see all 117):
    (articles sorted by number of sources associating them with MANF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons. (PubMed id 12794311)1, 2, 3, 9 Petrova P....Commissiong J.W. (2003)
    2. Mutations in the arginine-rich protein gene (ARP) in pancreatic cancer. (PubMed id 9174057)1, 2, 9 Shridhar V....Smith D.I. (1997)
    3. A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas. (PubMed id 8649854)1, 2, 9 Shridhar V.... Smith D.I. (1996)
    4. Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck. (PubMed id 8971156)1, 2, 9 Shridhar R.... Smith D.I. (1996)
    5. The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional. (PubMed id 19258449)1, 2 Parkash V.... Goldman A. (2009)
    6. Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death. (PubMed id 18561914)1, 2 Apostolou A....Fang S. (2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    9. Polymorphic variation of the ARP gene on 3p21 in Japanese esophageal cancer patients. (PubMed id 10767373)1, 9 Tanaka H....Ishizaki K. (2000)
    10. Normal polymorphism in the incomplete trinucleotide repeat of the arginine-rich protein gene. (PubMed id 9230196)1, 9 Evron E....Sidransky D. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7873 HGNC: 15461 AceView: ARMET Ensembl:ENSG00000145050 euGenes: HUgn7873
    ECgene: MANF H-InvDB: MANF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MANF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MANF gene:
    Search GeneIP for patents involving MANF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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