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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MANF Gene

protein-coding   GIFtS: 49
GCID: GC03P051399

mesencephalic astrocyte-derived neurotrophic factor

(Previous names: arginine-rich, mutated in early stage tumors )
(Previous symbol: ARMET)
 Explore 30 diseases affiliated with
MANF via
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Biological research products
for MANF    

Aliases
for MANF gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mesencephalic Astrocyte-Derived Neurotrophic Factor1 2
ARMET1 2 3 5
ARP1 2 3 5
Arginine-Rich, Mutated In Early Stage Tumors1 2
Arginine-Rich Protein3
Protein ARMET3

External Ids:    HGNC: 154611   Entrez Gene: 78732   Ensembl: ENSG000001450507   OMIM: 6019165   UniProtKB: P551453   

Export aliases for MANF gene to outside databases


Summaries
for MANF gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MANF:
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted.
Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation.
The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but
transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of
polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50
from ATG to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to
exist in normal tissues and are thus not tumor-related. (provided by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: MANF_HUMAN, P55145
Function: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic
transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic
inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic
reticulum (ER) stress-induced cell death

Gene Wiki entry for MANF (ARMET)


Genomic Views
for MANF gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MANF
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MANF promoter sequence
   Search SABiosciences Chromatin IP Primers for MANF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MANF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21.1

MANF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MANF gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P051399:  view genomic region     (about GC identifiers)

Start:
 51,422,478 bp from pter      End:
 51,426,828 bp from pter
Size:
 4,351 bases      Orientation:
 plus strand

1 alternative location:
Chr3+,PATCHES 51,420,984-51,425,120     

Proteins
for MANF gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MANF_HUMAN, P55145 (See protein sequence)
Recommended Name: Mesencephalic astrocyte-derived neurotrophic factor precursor  
Size: 182 amino acids; 20700 Da
Subcellular location: Secreted
Caution: Was originally (PubMed:8649854, PubMed:8971156 and PubMed:9174057) thought to be much longer and included an
arginine-rich region thought to be the target of cancer-causing mutations. All these mutations are in what is now
thought to be the 5'-UTR of the mRNA
Caution: It is uncertain whether Met-1 or Met-4 is the initiator
Sequence caution: Sequence=AAB08753.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAI13589.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAI13591.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for MANF:
2KVD (3D)        2KVE (3D)        2W51 (3D)    
Secondary accessions: Q14CX4 Q86U67 Q96IS4

Explore the universe of human proteins at neXtProt for MANF: NX_P55145

Post-translational modifications:

  • May contain sialic acid residues1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P55145

    • MANF Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006001.3  
    ENSEMBL proteins: 
     ENSP00000432799   ENSP00000405280  

    Human Recombinant Protein Products: 
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    Novus Biologicals MANF Proteins
    Novus Biologicals MANF Lysates
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    ProSpec Recombinant Protein for MANF
    Uscn Proteins for MANF

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005615extracellular space IEA--
    GO:0005783endoplasmic reticulum ----
    GO:0048471perinuclear region of cytoplasm IEA--


    MANF for ontologies           About GeneDecksing



    MANF Antibody Products: 
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    Protein Domains /
    Families
    for MANF gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MANF for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR019345 Armet_prot
     IPR011001 Saposin-like

    Graphical View of Domain Structure for InterPro Entry P55145

    ProtoNet protein and cluster: P55145

    UniProtKB/Swiss-Prot: MANF_HUMAN, P55145
    Domain: The N-terminal region may be responsible for neurotrophic activity while the C-terminal region may play a role
    in the ER stress response
    Similarity: Belongs to the ARMET family


    Function
    for MANF gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MANF_HUMAN, P55145
    Function: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic
    transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic
    inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic
    reticulum (ER) stress-induced cell death
    Induction: By endoplasmic reticulum stress

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MANF
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate MANF:
    hsa-miR-520d-5p hsa-miR-605 hsa-miR-524-5p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: MANF 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MANF (see all 4)
    OriGene shRNA RFP: MANF
    OriGene siRNA: MANF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MANF

    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MANF (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MANF 

    Cell Line
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    Search LifeMap BioReagents cell lines for MANF

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0008083growth factor activity IEA--


    MANF for ontologies           About GeneDecksing



    Pathways & Interactions
    for MANF gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MANF

    3 Interacting proteins for MANF (P551453) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3GL3Q999633I2D: score=5 
    ZFR2Q9UPR63I2D: score=2 
    IKBKEQ141643I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002014vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure IEA--
    GO:0006986response to unfolded protein IEA--
    GO:0008150biological_process ND--


    MANF for ontologies           About GeneDecksing



    Drugs & Compounds
    for MANF gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MANF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MANF
    8 Novoseek chemical compound relationships for MANF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arginine 76.2 68 8390981 (3), 2243097 (2), 8525706 (2), 15210328 (2) (see all 46)
    citrulline 74.5 12 18923650 (1), 15854045 (1), 14579251 (1), 15555572 (1) (see all 12)
    serine 70.8 51 15010457 (2), 15501179 (2), 15210328 (2), 12628928 (1) (see all 41)
    protamine 58.7 6 8390981 (2), 1370607 (1), 2081589 (1), 7765714 (1)
    lysine 47 13 11496758 (2), 8390981 (1), 20455659 (1), 18348515 (1) (see all 9)
    proline 46.3 8 8325374 (2), 8576182 (1), 8798599 (1), 7921540 (1) (see all 6)
    calcium 0 2 12392711 (1), 17851584 (1)
    glutamate 0 1 12216496 (1)

    Search CenterWatch for drugs/clinical trials and news about MANF 

    Transcripts
    for MANF gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MANF gene: 
    NM_006010.4  

    Unigene Cluster for MANF:

    Mesencephalic astrocyte-derived neurotrophic factor
    Hs.436446  [show with all ESTs]
    Unigene Representative Sequence: BM916000
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528157(uc003dbc.3) ENST00000446668 ENST00000470900 ENST00000482262


    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate MANF:
    hsa-miR-520d-5p hsa-miR-605 hsa-miR-524-5p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: MANF 3' UTR sequence
    Inhib. RNA
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    OriGene siRNA: MANF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MANF
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK292243.1 BC007282.1 BC113588.1 BC113590.1 BT007110.1 M83751.1 

    8 DOTS entries:

    DT.417163  DT.101983789  DT.91964159  DT.100789418  DT.91644036  DT.91756086  DT.120864260  DT.91932689 

    24/359 AceView cDNA sequences (see all 359):

    BI789224 BI962721 BM142133 AA416623 BM023246 AI092884 BQ924909 BM809540 
    AA460517 BM142042 BM907484 AU185615 AI032929 BM560999 AI929047 BE395150 
    BG992208 BU543965 BM023535 BU736869 BE046924 BM971504 AI140352 CB529516 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MANF    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5
    SP1:                    -               
    SP2:                                    


    ECgene alternative splicing isoforms for MANF

    Expression
    for MANF gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MANF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGGGATTCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MANF expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MANF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MANF

    SOURCE GeneReport for Unigene cluster: Hs.436446
        SABiosciences Expression via Pathway-Focused PCR Array including MANF: 
              Unfolded Protein Response in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for MANF gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MANF gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MANF6
    		 Uncharacterized protein
    		 78(a)
    		 1 ↔ 1
    		 12(2071566-2075486)
    lizard
    (Anolis carolinensis)    		 Reptilia MANF6
    		 --
    		 78(a)
    		 1 ↔ 1
    		 2(152084196-152093497)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.31352 Xenopus laevis, Similar to arginine-rich, mutated in more 77.62(n)    BC043846.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.149312 Transcribed sequence with weak similarity to protein more 76.39(n)    BM775555.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Manf1 Mesencephalic astrocyte-derived neurotrophic factor 57.56(n)
    55.33(a)    		   41983  NM_058097.4  NP_477445.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y54G2A.231 Protein Y54G2A.23 55.14(n)
    50.31(a)    		   177074  NM_067872.4  NP_500273.2 


    ENSEMBL Gene Tree for MANF (if available)
    TreeFam Gene Tree for MANF (if available) 

    Paralogs
    for MANF gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MANF gene
    CDNF2  
    1 SIMAP similar gene for MANF using alignment to 2 protein entries:     MANF_HUMAN (see all proteins):
    CDNF

    MANF for paralogs           About GeneDecksing



    Genomic Variants
    for MANF gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/64 NCBI SNPs in MANF are shown (see all 64)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs13701241,2
    		C,F,A,H,--51422188(-) ACGGAT/CCCAAC 2 -- us2k122Minor allele frequency- C:0.22MN EA NS NA WA CSA 4079
    rs1415858361,2
    		--51422262(+) TTCCTA/GCCTAA 1 -- us2k10--------
    rs1896686831,2
    		--51422461(+) CCCAAA/GATGGC 1 -- us2k10--------
    rs130919311,2
    		C,F,--51422766(+) GAGGAT/GGAGGA 2 -- ut51 ese3 trp34Minor allele frequency- G:0.17NA CSA EA 125
    rs130919321,2
    		C--51422769(+) GAGGAA/GGAGGA 2 -- ut51 ese3 trp30--------
    rs729457081,2
    		C,--51422904(+) GTGACC/GGTTCT 2 -- int10--------
    rs98419631,2
    		C,F,--51423088(+) TTGAGA/GCTAGA 1 -- int11Minor allele frequency- G:0.04WA 118
    rs738374421,2
    		C,--51423110(+) ACTTGT/GCCTGA 2 -- int14Minor allele frequency- G:0.25WA CSA EA 241
    rs1826991841,2
    		--51423145(+) GTCCCC/TACCAC 1 -- int10--------
    rs1864302241,2
    		--51423196(+) CAGGGC/TTGGCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for MANF (51422478 - 51426828 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MANF: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MANF
    DNA2.0 Custom Variant and Variant Library Synthesis for MANF

    Disorders / Diseases
    for MANF gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MANF for disorders           About GeneDecksing

    OMIM gene information: 601916    OMIM disorders: --

    20/30 diseases for MANF (see all 30):    About MalaCards
    dna topoisomerase i    growth hormone deficiency    essential tremor    squamous cell carcinoma of the head and neck
    cleft lip    squamous cell carcinoma    cytomegalovirus infection    brain injury
    rheumatoid arthritis    renal cell carcinoma    glaucoma    tremor
    neurodegenerative disease    parkinson's disease    arthritis    esophageal cancer
    carcinoma    twinning    esophagitis    periodontitis

    5 Novoseek disease relationships for MANF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 12.7 1 18923650 (1)
    carcinoma renal cell 12.1 1 9230196 (1)
    carcinoma squamous cell 5.72 1 1370607 (1)
    cancer 3.14 3 9174057 (1), 10767373 (1)
    tumors 0 2 9174057 (1), 9230196 (1)


    Export disorders for MANF gene to outside databases

    Publications
    for MANF gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MANF gene, integrated from 9 sources (see all 115):
    (articles sorted by number of sources associating them with MANF)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons. (PubMed id 12794311)1, 2, 3, 9 Petrova P....Commissiong J.W. (2003)
    2. Mutations in the arginine-rich protein gene (ARP) in pancreatic cancer. (PubMed id 9174057)1, 2, 9 Shridhar V....Smith D.I. (1997)
    3. A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas. (PubMed id 8649854)1, 2, 9 Shridhar V.... Smith D.I. (1996)
    4. Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck. (PubMed id 8971156)1, 2, 9 Shridhar R.... Smith D.I. (1996)
    5. The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional. (PubMed id 19258449)1, 2 Parkash V.... Goldman A. (2009)
    6. Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death. (PubMed id 18561914)1, 2 Apostolou A....Fang S. (2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    9. Polymorphic variation of the ARP gene on 3p21 in Japanese esophageal cancer patients. (PubMed id 10767373)1, 9 Tanaka H....Ishizaki K. (2000)
    10. Normal polymorphism in the incomplete trinucleotide repeat of the arginine-rich protein gene. (PubMed id 9230196)1, 9 Evron E....Sidransky D. (1997)

    External Searches for MANF gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing MANF gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7873 HGNC: 15461 AceView: ARMET Ensembl:ENSG00000145050 euGenes: HUgn7873
    ECgene: MANF H-InvDB: MANF

    Other Databases showing MANF gene

    (According to HUGE)
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    Specialized Databases showing MANF gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MANF Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MANF gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MANF gene:
    Search GeneIP for patents involving MANF

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