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Aliases for MANEAL Gene

Aliases for MANEAL Gene

  • Mannosidase, Endo-Alpha-Like 2 3
  • EC 63
  • EC 3.2.1.- 4

External Ids for MANEAL Gene

Previous GeneCards Identifiers for MANEAL Gene

  • GC01P037930
  • GC01P038032
  • GC01P038259
  • GC01P036378

Summaries for MANEAL Gene

GeneCards Summary for MANEAL Gene

MANEAL (Mannosidase, Endo-Alpha-Like) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is MANEA.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MANEAL Gene

Genomics for MANEAL Gene

Regulatory Elements for MANEAL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MANEAL Gene

37,793,802 bp from pter
37,801,606 bp from pter
7,805 bases
Plus strand

Genomic View for MANEAL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MANEAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MANEAL Gene

Proteins for MANEAL Gene

  • Protein details for MANEAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glycoprotein endo-alpha-1,2-mannosidase-like protein
    Protein Accession:
    Secondary Accessions:
    • Q6DD86
    • Q6P497
    • Q8N5P8
    • Q96G55
    • Q96N42

    Protein attributes for MANEAL Gene

    457 amino acids
    Molecular mass:
    51317 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MANEAL Gene


neXtProt entry for MANEAL Gene

Proteomics data for MANEAL Gene at MOPED

Selected DME Specific Peptides for MANEAL Gene

Post-translational modifications for MANEAL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MANEAL Gene

Domains for MANEAL Gene

Protein Domains for MANEAL Gene


Suggested Antigen Peptide Sequences for MANEAL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5VSG8
  • Belongs to the glycosyl hydrolase 99 family.
genes like me logo Genes that share domains with MANEAL: view

No data available for Gene Families for MANEAL Gene

Function for MANEAL Gene

Enzyme Numbers (IUBMB) for MANEAL Gene

Gene Ontology (GO) - Molecular Function for MANEAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MANEAL: view

Phenotypes for MANEAL Gene

GenomeRNAi human phenotypes for MANEAL:
genes like me logo Genes that share phenotypes with MANEAL: view

Animal Model Products

CRISPR Products

miRNA for MANEAL Gene

miRTarBase miRNAs that target MANEAL

No data available for Molecular function , Animal Models , Transcription Factor Targeting and HOMER Transcription for MANEAL Gene

Localization for MANEAL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MANEAL Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for MANEAL Gene COMPARTMENTS Subcellular localization image for MANEAL gene
Compartment Confidence
golgi apparatus 5

Gene Ontology (GO) - Cellular Components for MANEAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MANEAL: view

Pathways for MANEAL Gene

SuperPathways for MANEAL Gene

No Data Available

Interacting Proteins for MANEAL Gene

Gene Ontology (GO) - Biological Process for MANEAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with MANEAL: view

No data available for Pathways by source for MANEAL Gene

Transcripts for MANEAL Gene


(8) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(5) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MANEAL Gene

Mannosidase, endo-alpha-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MANEAL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MANEAL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for MANEAL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MANEAL Gene

mRNA expression in normal human tissues for MANEAL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MANEAL Gene

This gene is overexpressed in Vitreous humor (43.6) and Fetal Brain (25.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MANEAL Gene

SOURCE GeneReport for Unigene cluster for MANEAL Gene Hs.534562

genes like me logo Genes that share expressions with MANEAL: view

Expression partners for MANEAL Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MANEAL Gene

Orthologs for MANEAL Gene

This gene was present in the common ancestor of animals.

Orthologs for MANEAL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MANEAL 35
  • 93.33 (n)
  • 98.24 (a)
  • 99 (a)
(Mus musculus)
Mammalia Maneal 35
  • 87.76 (n)
  • 93.81 (a)
Maneal 16
Maneal 36
  • 95 (a)
(Pan troglodytes)
Mammalia MANEAL 35
  • 99.64 (n)
  • 99.56 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Maneal 35
  • 84.22 (n)
  • 88.5 (a)
(Canis familiaris)
Mammalia MANEAL 36
  • 90 (a)
(Monodelphis domestica)
Mammalia MANEAL 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia MANEAL 36
  • 88 (a)
(Gallus gallus)
Aves MANEAL 35
  • 77.23 (n)
  • 79.85 (a)
  • 78 (a)
(Anolis carolinensis)
Reptilia MANEAL 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia manea 35
  • 69.44 (n)
  • 76.39 (a)
(Danio rerio)
Actinopterygii si:ch211-30b16.2 35
  • 67.21 (n)
  • 69.46 (a)
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14015 36
  • 24 (a)
Species with no ortholog for MANEAL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MANEAL Gene

Gene Tree for MANEAL (if available)
Gene Tree for MANEAL (if available)

Paralogs for MANEAL Gene

Paralogs for MANEAL Gene

Selected SIMAP similar genes for MANEAL Gene using alignment to 3 proteins: Pseudogenes for MANEAL Gene

genes like me logo Genes that share paralogs with MANEAL: view

Variants for MANEAL Gene

Sequence variations from dbSNP and Humsavar for MANEAL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs10226 -- 37,800,997(-) AATAT(C/G)CATCT utr-variant-3-prime
rs530225 -- 37,799,147(-) atggg(A/C)cttgc intron-variant
rs810253 -- 37,797,379(+) ctggg(C/T)gacag intron-variant
rs2306627 -- 37,794,831(+) TGGTC(C/T)CACTT intron-variant, upstream-variant-2KB
rs4307531 -- 37,793,307(+) gaatt(C/T)tgcca upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MANEAL Gene

Variant ID Type Subtype PubMed ID
nsv871810 CNV Loss 21882294

Relevant External Links for MANEAL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MANEAL Gene

Disorders for MANEAL Gene

(1) University of Copenhagen DISEASES for MANEAL Gene

genes like me logo Genes that share disorders with MANEAL: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for MANEAL Gene

Publications for MANEAL Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MANEAL Gene

Sources for MANEAL Gene

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