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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MANEAL Gene

protein-coding GIFtS: 45
GCID: GC01P038259

mannosidase, endo-alpha-like

Explore 1 disease affiliated with
MANEAL via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mannosidase, Endo-Alpha-Like¹ ²
FLJ31434¹
RP11-109P14.3²
Glycoprotein Endo-Alpha-1,2-Mannosidase-Like Protein²
EC 3.2.1.-³
EC 3.2.1.130⁸

External Ids:	HGNC: 26452¹	Entrez Gene: 149175²	Ensembl: ENSG00000185090⁷	UniProtKB: Q5VSG8³

Export aliases for MANEAL gene to outside databases

Previous GC identifers: GC01P037930 GC01P038032 GC01P036378

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MANEAL gene promoter:
COUP-TF1 COUP-TF HFH-1 COUP HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MANEAL promoter sequence

Search SABiosciences Chromatin IP Primers for MANEAL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MANEAL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3 Ensembl cytogenetic band: 1p34.3 HGNC cytogenetic band: 1p34.3

MANEAL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MANEAL gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P038259: view genomic region (about GC identifiers)

Start:	38,259,474 bp from pter	End:	38,267,278 bp from pter
Size:	7,805 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MANEL_HUMAN, Q5VSG8 (See protein sequence)

Recommended Name: Glycoprotein endo-alpha-1,2-mannosidase-like protein

Size: 457 amino acids; 51317 Da

Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)

Secondary accessions: Q6DD86 Q6P497 Q8N5P8 Q96G55 Q96N42

Alternative splicing: 3 isoforms: Q5VSG8-1 Q5VSG8-2 Q5VSG8-3

Explore the universe of human proteins at neXtProt for MANEAL: NX_Q5VSG8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5VSG8

4 DME Specific Peptides for MANEAL (Q5VSG8)

GSSHQNW

FIALLVEE

ITSFNEWHEGTQIE

FIPSVGPGYIDTSIRPWN

MANEAL Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001026910.1 NP_001106954.1 NP_689709.1

ENSEMBL proteins:

ENSP00000362136 ENSP00000380755 ENSP00000432567 ENSP00000437312 ENSP00000328770

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	Uscn Proteins for MANEAL

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

MANEAL for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MANEAL for domains About GeneDecksing

1 InterPro domain/family:

IPR026071 Glyco_Hydrolase_99

Graphical View of Domain Structure for InterPro Entry Q5VSG8

ProtoNet protein and cluster: Q5VSG8

UniProtKB/Swiss-Prot: MANEL_HUMAN, Q5VSG8

Similarity: Belongs to the glycosyl hydrolase 99 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Enzyme Numbers (IUBMB): EC 3.2.1.130² EC 3.2.1.-¹

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016787	hydrolase activity	IEA	--

MANEAL for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for MANEAL:

Increased G2M DNA content

Increased gamma-H2AX phosphory

Animal Models:

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		hsa-miR-3194-5p hsa-miR-187* hsa-miR-27a hsa-miR-202 hsa-miR-128 hsa-miR-3681* hsa-miR-211 hsa-miR-204

		SwitchGear 3'UTR luciferase reporter plasmid: MANEAL 3' UTR sequence

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MANEAL

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MANEAL

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for MANEAL gene (3 alternative transcripts):

NM_001031740.2 NM_001113482.1 NM_152496.2

Unigene Clusters for MANEAL:

Mannosidase, endo-alpha-like

Hs.534562 [show with all ESTs], Hs.706404

Unigene Representative Sequences: NM_001113482, BC038190

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000373045(uc001cby.2) ENST00000397631(uc001cbx.2) ENST00000532512

ENST00000525897 ENST00000329006(uc001cbz.2)

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		hsa-miR-3194-5p hsa-miR-187* hsa-miR-27a hsa-miR-202 hsa-miR-128 hsa-miR-3681* hsa-miR-211 hsa-miR-204

		SwitchGear 3'UTR luciferase reporter plasmid: MANEAL 3' UTR sequence

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		Sirion Biotech Custom design and validation of potent shRNA sequences against MANEAL

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Additional cDNA sequence: BC038190.1

8 DOTS entries:

DT.100775868 DT.91737100 DT.100015823 DT.100775870 DT.121454748 DT.121329221 DT.40273368 DT.121109708

5 AceView cDNA sequences:

BC038190 BX115437 BE779767 BE218495 AW341178

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for MANEAL About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b
SP1:							-						-		-
SP2:							-
SP3:							-				-
SP4:											-

ECgene alternative splicing isoforms for MANEAL

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MANEAL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCAGTGCTA

About this image

MANEAL expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Forelimb Myotome

Limb Muscle Progenitor Cells

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MANEAL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MANEAL

SOURCE GeneReport for Unigene clusters: Hs.534562 Hs.706404

SABiosciences Custom PCR Arrays for MANEAL

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MANEAL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MANEAL gene from 3/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MANEAL¹	mannosidase, endo-alpha-like	77.16(n) 79.81(a)		419611 XM_417758.3 XP_417758.2
zebrafish (Danio rerio)	Actinopterygii	si:ch211-30b16.2¹	si:ch211-30b16.2	67.05(n) 69.79(a)		566679 NM_001045114.1 NP_001038579.1
fruit fly (Drosophila melanogaster)	Insecta	CG14015⁶	--	23(a)	1 → many	2L(5536850-5539196)

ENSEMBL Gene Tree for MANEAL (if available)
TreeFam Gene Tree for MANEAL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MANEAL gene

MANEA²

1 SIMAP similar gene for MANEAL using alignment to 3 protein entries: MANEL_HUMAN (see all proteins):

MANEA

MANEAL for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for MANEAL
PGOHUM00000240355

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192100625^1,2		--	38257885(+)	`CTCCAA/CAAATG`	2	--	us2k¹		0	--	--	--	--
rs28380245^1,2	C,F,H	--	38258005(+)	`ACTTCT/GGGGAA`	2	--	us2k¹ tfbs³		10		NS EA	1572
rs12030690^1,2	C	--	38258007(+)	`TTCTGG/CGAAAG`	2	--	us2k¹ tfbs³ trp³		3		NA EA	242
rs185079293^1,2		--	38258139(+)	`TGAGAC/TGGGAA`	2	--	us2k¹		0	--	--	--	--
rs187885636^1,2		--	38258300(+)	`TTCATA/TCACAT`	2	--	us2k¹		0	--	--	--	--
rs79486268^1,2		--	38258376(+)	`CCCTGC/ATCCTC`	2	--	us2k¹		1		EA	120
rs192334345^1,2		--	38258386(+)	`CTTCCC/TGGGTT`	2	--	us2k¹		0	--	--	--	--
rs138594964^1,2		--	38258632(+)	`CTGGTA/GCTCAC`	2	--	us2k¹		0	--	--	--	--
rs12563037^1,2	C,F,A,H	--	38258644(+)	`TAAACG/CGCACT`	2	--	us2k¹		27		NS EA NA	3072
rs117956596^1,2		--	38258798(+)	`TTTACG/AGGAAC`	2	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for MANEAL (38259474 - 38267278 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MANEAL: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MANEAL

DNA2.0 Custom Variant and Variant Library Synthesis for MANEAL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MANEAL for disorders About GeneDecksing

1 disease for MANEAL: About MalaCards

duodenum cancer

1 disease from the University of Copenhagen DISEASES database for MANEAL:

Duodenum cancer

Export disorders for MANEAL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MANEAL gene integrated from 9 sources:
(articles sorted by number of sources associating them with MANEAL)

Utopia: connect your pdf to the dynamic
world of online information

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 149175	HGNC: 26452	AceView: FLJ31434.1	Ensembl:ENSG00000185090	euGenes: HUgn149175
ECgene: MANEAL	H-InvDB: MANEAL

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MANEAL	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MANEAL gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MANEAL gene:
Search GeneIP for patents involving MANEAL

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	GenScript Custom Purified and Recombinant Proteins Services for MANEAL		GenScript cDNA clones with any tag delivered in your preferred vector for MANEAL
	GenScript Custom Assay Services for MANEAL		GenScript Custom Superior Antibodies Services for MANEAL
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	Regulatory tfbs in MANEAL promoter
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	RT² qPCR Primer Assay in human, mouse, rat MANEAL
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MANEAL

	SwitchGear 3'UTR luciferase reporter plasmids for MANEAL
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Search ThermoFisher Antibodies for MANEAL

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MANEAL

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MANEAL

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MANEAL gene at Home site.

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MANEAL Gene

mannosidase, endo-alpha-like

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for MANEAL gene

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for MANEAL gene

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Pathways & Interactions
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Export list of displayed genes

MANEAL Gene

mannosidase, endo-alpha-like

Aliasesfor MANEAL gene

Summariesfor MANEAL gene

Genomic Viewsfor MANEAL gene

Proteinsfor MANEAL gene

Protein Domains /Familiesfor MANEAL gene

Functionfor MANEAL gene

Pathways & Interactionsfor MANEAL gene

Drugs & Compoundsfor MANEAL gene

Transcriptsfor MANEAL gene

Expression for MANEAL gene

Orthologsfor MANEAL gene

Paralogsfor MANEAL gene

Genomic Variantsfor MANEAL gene

Disorders / Diseasesfor MANEAL gene

Publicationsfor MANEAL gene

External Searches for MANEAL gene

Genome Databases showing MANEAL gene

Other Databases showing MANEAL gene

Specialized Databases showing MANEAL gene

Intellectual Propertyfor MANEAL gene

Productsfor MANEAL gene

View Random Gene

Aliases
for MANEAL gene

Summaries
for MANEAL gene

Genomic Views
for MANEAL gene

Proteins
for MANEAL gene

Protein Domains /
Families
for MANEAL gene

Function
for MANEAL gene

Pathways & Interactions
for MANEAL gene

Drugs & Compounds
for MANEAL gene

Transcripts
for MANEAL gene

Expression
for MANEAL gene

Orthologs
for MANEAL gene

Paralogs
for MANEAL gene

Genomic Variants
for MANEAL gene

Disorders / Diseases
for MANEAL gene

Publications
for MANEAL gene

Intellectual Property
for MANEAL gene

Products
for MANEAL gene