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Aliases for MANEAL Gene

Aliases for MANEAL Gene

  • Mannosidase Endo-Alpha Like 2 3 5
  • Mannosidase, Endo-Alpha-Like 2
  • EC 61
  • EC 3.2.1.- 4

External Ids for MANEAL Gene

Previous GeneCards Identifiers for MANEAL Gene

  • GC01P037930
  • GC01P038032
  • GC01P038259
  • GC01P036378

Summaries for MANEAL Gene

GeneCards Summary for MANEAL Gene

MANEAL (Mannosidase Endo-Alpha Like) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is MANEA.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MANEAL Gene

Genomics for MANEAL Gene

Regulatory Elements for MANEAL Gene

Enhancers for MANEAL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MANEAL on UCSC Golden Path with GeneCards custom track

Promoters for MANEAL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MANEAL Gene

37,793,802 bp from pter
37,801,606 bp from pter
7,805 bases
Plus strand

Genomic View for MANEAL Gene

Genes around MANEAL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MANEAL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MANEAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MANEAL Gene

Proteins for MANEAL Gene

  • Protein details for MANEAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glycoprotein endo-alpha-1,2-mannosidase-like protein
    Protein Accession:
    Secondary Accessions:
    • Q6DD86
    • Q6P497
    • Q8N5P8
    • Q96G55
    • Q96N42

    Protein attributes for MANEAL Gene

    457 amino acids
    Molecular mass:
    51317 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MANEAL Gene


neXtProt entry for MANEAL Gene

Selected DME Specific Peptides for MANEAL Gene

Post-translational modifications for MANEAL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MANEAL Gene

Domains & Families for MANEAL Gene

Gene Families for MANEAL Gene

Protein Domains for MANEAL Gene


Suggested Antigen Peptide Sequences for MANEAL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 99 family.
  • Belongs to the glycosyl hydrolase 99 family.
genes like me logo Genes that share domains with MANEAL: view

Function for MANEAL Gene

Enzyme Numbers (IUBMB) for MANEAL Gene

Gene Ontology (GO) - Molecular Function for MANEAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MANEAL: view
genes like me logo Genes that share phenotypes with MANEAL: view

Animal Models for MANEAL Gene

MGI Knock Outs for MANEAL:

Animal Model Products

CRISPR Products

miRNA for MANEAL Gene

miRTarBase miRNAs that target MANEAL

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MANEAL Gene

Localization for MANEAL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MANEAL Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for MANEAL Gene COMPARTMENTS Subcellular localization image for MANEAL gene
Compartment Confidence
golgi apparatus 4

Gene Ontology (GO) - Cellular Components for MANEAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MANEAL: view

Pathways & Interactions for MANEAL Gene

SuperPathways for MANEAL Gene

No Data Available

Interacting Proteins for MANEAL Gene

Selected Interacting proteins: Q5VSG8-MANEL_HUMAN for MANEAL Gene via IID

Gene Ontology (GO) - Biological Process for MANEAL Gene


No data available for Pathways by source and SIGNOR curated interactions for MANEAL Gene

Drugs & Compounds for MANEAL Gene

No Compound Related Data Available

Transcripts for MANEAL Gene


(5) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MANEAL Gene

Mannosidase, endo-alpha-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MANEAL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: - - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for MANEAL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MANEAL Gene

mRNA expression in normal human tissues for MANEAL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MANEAL Gene

This gene is overexpressed in Vitreous humor (43.6) and Fetal Brain (25.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MANEAL Gene

Protein tissue co-expression partners for MANEAL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MANEAL Gene:


SOURCE GeneReport for Unigene cluster for MANEAL Gene:

genes like me logo Genes that share expression patterns with MANEAL: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MANEAL Gene

Orthologs for MANEAL Gene

This gene was present in the common ancestor of animals.

Orthologs for MANEAL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MANEAL 34
  • 93.33 (n)
  • 98.24 (a)
  • 99 (a)
(Mus musculus)
Mammalia Maneal 34
  • 87.76 (n)
  • 93.81 (a)
Maneal 16
Maneal 35
  • 95 (a)
(Pan troglodytes)
Mammalia MANEAL 34
  • 99.64 (n)
  • 99.56 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Maneal 34
  • 84.22 (n)
  • 88.5 (a)
(Canis familiaris)
Mammalia MANEAL 35
  • 90 (a)
(Monodelphis domestica)
Mammalia MANEAL 35
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia MANEAL 35
  • 88 (a)
(Gallus gallus)
Aves MANEAL 34
  • 77.23 (n)
  • 79.85 (a)
  • 78 (a)
(Anolis carolinensis)
Reptilia MANEAL 35
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia manea 34
  • 69.44 (n)
  • 76.39 (a)
(Danio rerio)
Actinopterygii si:ch211-30b16.2 34
  • 67.21 (n)
  • 69.46 (a)
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14015 35
  • 24 (a)
Species where no ortholog for MANEAL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MANEAL Gene

Gene Tree for MANEAL (if available)
Gene Tree for MANEAL (if available)

Paralogs for MANEAL Gene

Paralogs for MANEAL Gene

(1) SIMAP similar genes for MANEAL Gene using alignment to 3 proteins: Pseudogenes for MANEAL Gene

genes like me logo Genes that share paralogs with MANEAL: view

Variants for MANEAL Gene

Sequence variations from dbSNP and Humsavar for MANEAL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10226 -- 37,800,997(-) AATAT(C/G)CATCT utr-variant-3-prime
rs530225 -- 37,799,147(-) atggg(A/C)cttgc intron-variant
rs810253 -- 37,797,379(+) ctggg(C/T)gacag intron-variant
rs2306627 -- 37,794,831(+) TGGTC(C/T)CACTT intron-variant, upstream-variant-2KB
rs4307531 -- 37,793,307(+) gaatt(C/T)tgcca upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MANEAL Gene

Variant ID Type Subtype PubMed ID
nsv1136077 CNV deletion 24896259

Variation tolerance for MANEAL Gene

Residual Variation Intolerance Score: 47.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MANEAL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MANEAL Gene

Disorders for MANEAL Gene

Relevant External Links for MANEAL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MANEAL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MANEAL Gene

Publications for MANEAL Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for MANEAL Gene

Sources for MANEAL Gene

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