Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MANEA Gene

protein-coding   GIFtS: 50
GCID: GC06P096025

Mannosidase, Endo-Alpha

  See MANEA-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Mannosidase, Endo-Alpha1 2     endomannosidase2
Endo-Alpha Mannosidase2 3     Glycoprotein Endo-Alpha-1,2-Mannosidase2
hEndo2 3     mandaselin2
EC 3.2.1.1303 8     Endomannosidase3
ENDO2 5     Mandaselin3
Alpha 1,2-Endomannosidase2     EC 3.2.18

External Ids:    HGNC: 210721   Entrez Gene: 796942   Ensembl: ENSG000001724697   OMIM: 6123275   UniProtKB: Q5SRI93   

Export aliases for MANEA gene to outside databases

Previous GC identifers: GC06P096071 GC06P096132 GC06P093458


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MANEA Gene:
N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled
oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the
target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by
several ER glycosidases and by an endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi. MANEA catalyzes
the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that
links them to high-mannose glycans (Hamilton et al., 2005 (PubMed 15677381)).(supplied by OMIM, Sep 2008)

GeneCards Summary for MANEA Gene:
MANEA (mannosidase, endo-alpha) is a protein-coding gene. Diseases associated with MANEA include dracunculiasis. GO annotations related to this gene include glycoprotein endo-alpha-1,2-mannosidase activity. An important paralog of this gene is MANEAL.

Gene Wiki entry for MANEA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the MANEA gene promoter:
         TBP   LUN-1   Nkx2-5   POU3F2   Meis-1b   FOXJ2 (long isoform)   TFIID   HSF2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MANEA promoter sequence
   Search Chromatin IP Primers for MANEA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MANEA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16.1   Ensembl cytogenetic band:  6q16.1   HGNC cytogenetic band: 6q16.2

MANEA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MANEA gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P096025:  view genomic region     (about GC identifiers)

Start:
96,025,373 bp from pter      End:
96,057,333 bp from pter
Size:
31,961 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MANEA_HUMAN, Q5SRI9 (See protein sequence)
Recommended Name: Glycoprotein endo-alpha-1,2-mannosidase  
Size: 462 amino acids; 53671 Da
Sequence caution: Sequence=AAL07306.1; Type=Frameshift; Positions=Several; Sequence=CAD97640.1; Type=Erroneous
initiation; Sequence=CAI17346.1; Type=Erroneous gene model prediction;
Secondary accessions: A6H8M6 Q5SRJ0 Q6MZV0 Q70JE9 Q7Z3V7 Q8WWX5 Q9H9D2

Explore the universe of human proteins at neXtProt for MANEA: NX_Q5SRI9

Explore proteomics data for MANEA at MOPED

Post-translational modifications: 

  • Undergoes proteolytic cleavage in the C-terminal region1
  • Glycosylation2 at Thr73, Ser78, Thr82, Ser86
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MANEA (Q5SRI9) (see all 9)
     GSSHQNW  LLVEEKH  FRRRTCI  FIALLVEE 


    See MANEA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078917.2  
    ENSEMBL proteins: 
     ENSP00000358299   ENSP00000351669  
    Reactome Protein details: Q5SRI9

    MANEA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MANEA
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MANEA
    GenScript Custom Purified and Recombinant Proteins Services for MANEA
    Novus Biologicals MANEA Protein
    Novus Biologicals MANEA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for MANEA 

     
    antibodies-online proteins for MANEA (4 products) 

     
    antibodies-online peptides for MANEA

    MANEA Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MANEA
    Novus Biologicals MANEA Antibodies
    Abcam antibodies for MANEA
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for MANEA
    antibodies-online antibodies for MANEA (3 products) 

    MANEA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MANEA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MANEA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for MANEA 
    antibodies-online kits for MANEA (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR017853 Glycoside_hydrolase_SF
     IPR026071 Glyco_Hydrolase_99

    Graphical View of Domain Structure for InterPro Entry Q5SRI9

    ProtoNet protein and cluster: Q5SRI9

    UniProtKB/Swiss-Prot: MANEA_HUMAN, Q5SRI9
    Similarity: Belongs to the glycosyl hydrolase 99 family


    Find genes that share domains with MANEA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MANEA_HUMAN, Q5SRI9
    Catalytic activity: Hydrolysis of the terminal alpha-D-glucosyl-(1,3)-D-mannosyl unit from the
    GlcMan(9)(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane
    Biophysicochemical properties: pH dependence: Optimum pH is 6.2; Temperature dependence: Optimum temperature is 37
    degrees Celsius;

         Enzyme Numbers (IUBMB): EC 3.2.1.1301 2 EC 3.2.12

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004559alpha-mannosidase activity ----
    GO:0004569glycoprotein endo-alpha-1,2-mannosidase activity IEA--
         
    Find genes that share ontologies with MANEA           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MANEA:
     Decreased viability with pacli 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MANEA

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MANEA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MANEA (see all 12):
    hsa-miR-4291 hsa-miR-4307 hsa-miR-495 hsa-miR-4251 hsa-miR-539 hsa-miR-7-2* hsa-miR-586 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidMANEA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MANEA
    Predesigned siRNA for gene silencing in human, mouse, rat MANEA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MANEA

    Clone
    Products:
         
    OriGene clones in human, mouse for MANEA (see all 7)
    OriGene ORF clones in mouse, rat for MANEA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MANEA (NM_024641)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MANEA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MANEA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MANEA
    Browse ESI BIO Cell Lines and PureStem Progenitors for MANEA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MANEA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MANEA_HUMAN, Q5SRI9: Golgi apparatus membrane; Single-pass type II membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular2
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus IDA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with MANEA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MANEA About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Metabolism of proteins0.30
    Post-translational protein modification0.43
    N-glycan trimming and elongation in the cis-Golgi0.00
    Transport to the Golgi and subsequent modification0.40


    Find genes that share SuperPaths with MANEA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for MANEA
        N-glycan trimming and elongation in the cis-Golgi


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MANEA
    Interactions:

        Search GeneGlobe Interaction Network for MANEA

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with MANEA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MANEA



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MANEA gene: 
    NM_024641.3  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369293(uc003pon.3) ENST00000358812(uc003poo.2) ENST00000474553

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MANEA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MANEA (see all 12):
    hsa-miR-4291 hsa-miR-4307 hsa-miR-495 hsa-miR-4251 hsa-miR-539 hsa-miR-7-2* hsa-miR-586 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidMANEA 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MANEA
    Predesigned siRNA for gene silencing in human, mouse, rat MANEA
    Clone
    Products:
         
    OriGene clones in human, mouse for MANEA (see all 7)
    OriGene ORF clones in mouse, rat for MANEA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MANEA (NM_024641)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MANEA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MANEA
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MANEA
    OriGene qSTAR qPCR primer pairs in human, mouse for MANEA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MANEA
      QuantiTect SYBR Green Assays in human, mouse, rat MANEA
      QuantiFast Probe-based Assays in human, mouse, rat MANEA

    Selected AceView cDNA sequences (see all 76):

    AI050667 AA826264 BF970329 AJ577574 BQ018032 CD678316 AA975408 NM_024641 
    CB321748 AI743863 AL697786 BX495562 AI650349 BI549404 BX503740 BX471708 
    AA761166 AA250932 BX102844 BG563404 AY048775 BG194979 AA846588 AA251061 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MANEA    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:              -     -                     
    SP2:                                          


    ECgene alternative splicing isoforms for MANEA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MANEA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MANEA Expression
    About this image


    MANEA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive streak-like cells
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Endoderm (Gastrulation Derivatives)
             Definitive endoderm-like cells
     
     Brain (Nervous System)
             Cerebellum
    MANEA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MANEA Protein Expression

    UniProtKB/Swiss-Prot: MANEA_HUMAN, Q5SRI9
    Tissue specificity: Highly expressed in the liver and kidney. Expressed at lower levels in muscle, pancreas,
    heart, placenta, lung and brain

        Custom PCR Arrays for MANEA
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MANEA
    OriGene qSTAR qPCR primer pairs in human, mouse for MANEA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MANEA
    QuantiTect SYBR Green Assays in human, mouse, rat MANEA
    QuantiFast Probe-based Assays in human, mouse, rat MANEA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MANEA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MANEA gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Manea1 , 5 mannosidase, endo-alpha1, 5 85.5(n)1
    85.5(a)1
      4 (10.92 cM)5
    2423621  NM_172865.21  NP_766453.21 
     263245065 
    chicken
    (Gallus gallus)
    Aves MANEA1 mannosidase, endo-alpha 72.55(n)
    72.19(a)
      421807  XM_004940369.1  XP_004940426.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004859321 glycoprotein endo-alpha-1,2-mannosidase-like 69.2(n)
    66.67(a)
      100485932  XM_002934870.2  XP_002934916.1 
    zebrafish
    (Danio rerio)
    Actinopterygii manea1 mannosidase, endo-alpha 61.16(n)
    59.17(a)
      447827  NM_001004566.2  NP_001004566.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG140151 CG14015 43(n)
    30.53(a)
      33780  NM_135093.4  NP_608937.1 


    ENSEMBL Gene Tree for MANEA (if available)
    TreeFam Gene Tree for MANEA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MANEA gene
    MANEAL2  
    1 SIMAP similar gene for MANEA using alignment to 1 protein entry:     MANEA_HUMAN:
    MANEAL

    Find genes that share paralogs with MANEA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MANEA (see all 671)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362424
    A breast cancer sample4--see VAR_0362422 Y C mis40--------
    rs92854131,2
    C--96023439(+) tcagcA/Gaagct 1 -- us2k110Minor allele frequency- G:0.12NA WA CSA EA 371
    rs1392544481,2
    --96023552(+) ATAAAA/CCTAGG 1 -- us2k10--------
    rs1891437251,2
    --96023563(+) AGGCAA/GTATAA 1 -- us2k10--------
    rs1499720711,2
    --96023633(+) ATATAC/TCATGT 1 -- us2k10--------
    rs69373021,2
    C,F,A--96023655(+) AAGACG/ATTTCA 1 -- us2k110Minor allele frequency- A:0.31NA WA CSA EA 372
    rs132059221,2
    C--96023692(+) TTGAAT/AAAAAT 1 -- us2k13Minor allele frequency- A:0.09NA EA 242
    rs69374791,2
    C,F,A,H--96023755(+) TTTCAT/ATGAAA 1 -- us2k114Minor allele frequency- A:0.39NS EA NA WA CSA 848
    rs1165530881,2
    C,F--96023757(+) TCAATG/CAAAGA 1 -- us2k11Minor allele frequency- C:0.09WA 118
    rs624178101,2
    C--96023779(+) AGTATA/GGTTAA 1 -- us2k13Minor allele frequency- G:0.07NA EA 242

    HapMap Linkage Disequilibrium report for MANEA (96025373 - 96057333 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MANEA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2656633CNV Deletion23128226
    esv2667481CNV Deletion23128226
    nsv518549CNV Loss19592680
    nsv886418CNV Loss21882294
    nsv463980CNV Loss19166990
    nsv819429CNV Gain19587683
    nsv886419CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MANEA
    DNA2.0 Custom Variant and Variant Library Synthesis for MANEA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612327    OMIM disorders: --

    1 disease for MANEA:    
    About MalaCards
    dracunculiasis

    2 diseases from the University of Copenhagen DISEASES database for MANEA:
    Dracunculiasis     Cocaine dependence

    Find genes that share disorders with MANEA           About GenesLikeMe

    Genetic Association Database (GAD): MANEA
    Human Genome Epidemiology (HuGE) Navigator: MANEA (4 documents)

    Export disorders for MANEA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MANEA gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with MANEA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Association of variants in MANEA with cocaine-related behaviors. (PubMed id 19255376)1, 4 Farrer L.A....Gelernter J. (Arch. Gen. Psychiatry 2009)
    3. Substance dependence low-density whole genome association study in two distinct American populations. (PubMed id 18438686)1, 4 Yu Y....Gelernter J. (Hum. Genet. 2008)
    4. Intact alpha-1,2-endomannosidase is a typical type II membrane protein. (PubMed id 15677381)1, 2 Hamilton S.R.... Gerngross T.U. (Glycobiology 2005)
    5. Human endo-alpha1,2-mannosidase is a Golgi-resident type II membrane protein. (PubMed id 15760709)1, 2 Hardt B....Bause E. (Biochimie 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 79694 HGNC: 21072 AceView: MANEA Ensembl:ENSG00000172469 euGenes: HUgn79694
    ECgene: MANEA H-InvDB: MANEA

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MANEA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MANEA gene:
    Search GeneIP for patents involving MANEA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MANEA  
     OriGene qPCR primer pairs and template standards for MANEA   OriGene Protein Over-expression Lysate for MANEA  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MANEA  
     OriGene qSTAR qPCR primer pairs in human, mouse for MANEA   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MANEA   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MANEA   OriGene Custom Protein Services for MANEA  

     
     
     Block miRNA regulation of human, mouse, rat MANEA using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MANEA
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MANEA Predesigned siRNA for gene silencing in human, mouse, rat MANEA
     QuantiFast Probe-based Assays in human, mouse, rat MANEA QuantiTect SYBR Green Assays in human, mouse, rat MANEA
     Custom PCR Arrays for MANEA Search Chromatin IP Primers for MANEA
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MANEA  Search GeneGlobe Interaction Network for MANEA
     Regulatory tfbs in MANEA promoter
     GenScript Custom Purified and Recombinant Proteins Services for MANEA GenScript cDNA clones with any tag delivered in your preferred vector for MANEA
     GenScript Custom Assay Services for MANEA GenScript Custom overexpressing Cell Line Services for MANEA
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MANEA
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MANEA antibodies
     MANEA proteins
     MANEA lysates
     Antibodies for MANEA
     See all of Abcam's Antibodies, Kits and Proteins for MANEA
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for MANEA
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MANEA
     SwitchGear 3'UTR luciferase reporter plasmids for MANEA
     SwitchGear Promoter luciferase reporter plasmids for MANEA
     ThermoFisher Antibodies for MANEA
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MANEA
     Browse compounds at ApexBio
     Search Addgene for plasmids for MANEA
      Search eBioscience for proteins for MANEA
      Search eBioscience for elisas for MANEA
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for MANEA
     antibodies-online antibodies for MANEA (3 products)
     antibodies-online kits for MANEA (4 products)
     antibodies-online peptides for MANEA
     antibodies-online proteins for MANEA (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MANEA gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4