Aliases for MANEA Gene
External Ids for MANEA Gene
Previous GeneCards Identifiers for MANEA Gene
N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER glycosidases and by an endomannosidase (E.C. 22.214.171.124), such as MANEA, in the Golgi. MANEA catalyzes the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to high-mannose glycans (Hamilton et al., 2005 [PubMed 15677381]).[supplied by OMIM, Sep 2008]
GeneCards Summary for MANEA Gene
MANEA (Mannosidase Endo-Alpha) is a Protein Coding gene. Diseases associated with MANEA include Substance Dependence and Dracunculiasis. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. GO annotations related to this gene include alpha-mannosidase activity and glycoprotein endo-alpha-1,2-mannosidase activity. An important paralog of this gene is MANEAL.