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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MANEA Gene

protein-coding   GIFtS: 53
GCID: GC06P096071

Mannosidase, Endo-Alpha

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mannosidase, Endo-Alpha1 2     endomannosidase2
Endo-Alpha Mannosidase2 3     Glycoprotein Endo-Alpha-1,2-Mannosidase2
hEndo2 3     mandaselin2
EC 3.2.1.1303 8     Endomannosidase3
ENDO2 5     Mandaselin3
Alpha 1,2-Endomannosidase2     EC 3.2.18

External Ids:    HGNC: 210721   Entrez Gene: 796942   Ensembl: ENSG000001724697   OMIM: 6123275   UniProtKB: Q5SRI93   

Export aliases for MANEA gene to outside databases

Previous GC identifers: GC06P096025 GC06P096132 GC06P093458


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MANEA Gene:
N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled
oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the
target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by
several ER glycosidases and by an endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi. MANEA catalyzes
the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that
links them to high-mannose glycans (Hamilton et al., 2005 (PubMed 15677381)).(supplied by OMIM, Sep 2008)

GeneCards Summary for MANEA Gene: 
MANEA (mannosidase, endo-alpha) is a protein-coding gene. Diseases associated with MANEA include dracunculiasis, and substance dependence, and among its related super-pathways are WNT ligand biogenesis and trafficking and Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2. GO annotations related to this gene include glycoprotein endo-alpha-1,2-mannosidase activity. An important paralog of this gene is MANEAL.

Gene Wiki entry for MANEA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MANEA gene promoter:
         TBP   LUN-1   Nkx2-5   POU3F2   Meis-1b   FOXJ2 (long isoform)   TFIID   HSF2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MANEA promoter sequence
   Search SABiosciences Chromatin IP Primers for MANEA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MANEA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16.1   Ensembl cytogenetic band:  6q16.1   HGNC cytogenetic band: 6q16.2

MANEA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MANEA gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P096071:  view genomic region     (about GC identifiers)

Start:
96,025,373 bp from pter      End:
96,057,333 bp from pter
Size:
31,961 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MANEA_HUMAN, Q5SRI9 (See protein sequence)
Recommended Name: Glycoprotein endo-alpha-1,2-mannosidase  
Size: 462 amino acids; 53671 Da
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein
Sequence caution: Sequence=AAL07306.1; Type=Frameshift; Positions=Several; Sequence=CAD97640.1; Type=Erroneous
initiation; Sequence=CAI17346.1; Type=Erroneous gene model prediction;
Secondary accessions: A6H8M6 Q5SRJ0 Q6MZV0 Q70JE9 Q7Z3V7 Q8WWX5 Q9H9D2

Explore the universe of human proteins at neXtProt for MANEA: NX_Q5SRI9

Explore proteomics data for MANEA at MOPED 

Post-translational modifications:

  • UniProtKB: Undergoes proteolytic cleavage in the C-terminal region
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5SRI9

  • 4/9 DME Specific Peptides for MANEA (Q5SRI9) (see all 9)
     GSSHQNW  LLVEEKH  FRRRTCI  FIALLVEE 

    MANEA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MANEA Protein Expression
    REFSEQ proteins: NP_078917.2  
    ENSEMBL proteins: 
     ENSP00000358299   ENSP00000351669  
    Reactome Protein details: Q5SRI9
    Human Recombinant Protein Products for MANEA: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals MANEA Protein
    Novus Biologicals MANEA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus IDA--
    GO:0016021integral to membrane IEA--

    MANEA for ontologies           About GeneDecksing



    MANEA Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for MANEA 

    Assay Products for MANEA: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR017853 Glycoside_hydrolase_SF
     IPR026071 Glyco_Hydrolase_99

    Graphical View of Domain Structure for InterPro Entry Q5SRI9

    ProtoNet protein and cluster: Q5SRI9

    UniProtKB/Swiss-Prot: MANEA_HUMAN, Q5SRI9
    Similarity: Belongs to the glycosyl hydrolase 99 family


    MANEA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MANEA_HUMAN, Q5SRI9
    Catalytic activity: Hydrolysis of the terminal alpha-D-glucosyl-(1,3)-D-mannosyl unit from the
    GlcMan(9)(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane
    Biophysicochemical properties: pH dependence: Optimum pH is 6.2; Temperature dependence: Optimum temperature is 37
    degrees Celsius;

         Enzyme Numbers (IUBMB): EC 3.2.1.1301 2 EC 3.2.12

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004559alpha-mannosidase activity ----
    GO:0004569glycoprotein endo-alpha-1,2-mannosidase activity IEA--
         
    MANEA for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MANEA:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MANEA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MANEA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MANEA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MANEA 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MANEA
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate MANEA (see all 12):
    hsa-miR-4291 hsa-miR-4307 hsa-miR-495 hsa-miR-4251 hsa-miR-539 hsa-miR-7-2* hsa-miR-586 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidMANEA 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MANEA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MANEA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MANEA
    Sirion Biotech Customized adenovirus for overexpression of MANEA

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for MANEA (see all 7)
    OriGene ORF clones in mouse, rat for MANEA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MANEA (NM_024641)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MANEA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MANEA
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                         Customized lentivirus expression plasmids for stable overexpression of MANEA 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MANEA
    Search LifeMap BioReagents cell lines for MANEA
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MANEA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MANEA About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    Post-translational protein modification0.44
    WNT ligand biogenesis and trafficking0.77
    Metabolism of proteins0.35
    Signaling by Wnt0.62
    2N-glycan trimming and elongation in the cis-Golgi
    N-glycan trimming and elongation in the cis-Golgi0.60
    3N-glycan antennae elongation in the medial/trans-Golgi
    Transport to the Golgi and subsequent modification0.56
    4Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/8        Reactome Pathways for MANEA (see all 8)
        Transport to the Golgi and subsequent modification
    Signaling by Wnt
    Asparagine N-linked glycosylation
    Signal Transduction
    Metabolism of proteins



    MANEA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MANEA

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    MANEA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MANEA

    Search CenterWatch for drugs/clinical trials and news about MANEA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MANEA gene: 
    NM_024641.3  

    Unigene Clusters for MANEA:

    Mannosidase, endo-alpha
    Hs.734632  [show with all ESTs], Hs.743412  [show with all ESTs]
    Unigene Representative Sequences: AY048775, BC150199
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369293(uc003pon.3) ENST00000358812(uc003poo.2) ENST00000474553

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MANEA
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate MANEA (see all 12):
    hsa-miR-4291 hsa-miR-4307 hsa-miR-495 hsa-miR-4251 hsa-miR-539 hsa-miR-7-2* hsa-miR-586 hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmidMANEA 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MANEA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MANEA
    Clone
    Products:
         
    OriGene clones in human, mouse for MANEA (see all 7)
    OriGene ORF clones in mouse, rat for MANEA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MANEA (NM_024641)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MANEA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MANEA
    Sirion Biotech Customized lentivirus for stable overexpression of MANEA 
                         Customized lentivirus expression plasmids for stable overexpression of MANEA 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MANEA
    OriGene qSTAR qPCR primer pairs in human, mouse for MANEA
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MANEA
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MANEA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MANEA

    Additional mRNA sequence: 

    AJ577574.1 AK022900.1 AK291940.1 AY048774.1 AY372528.1 BC137014.1 BC137016.1 BC146671.1 
    BC150199.1 BX537398.1 BX640869.1 CR936827.1 

    2 DOTS entries:

    DT.209802  DT.70103586 

    24/76 AceView cDNA sequences (see all 76):

    AI050667 AA975408 AJ577574 CD678316 AA826264 BQ018032 BF970329 AI093091 
    BX496891 AY048774 BM729307 AA251061 BX495562 AL710783 AA360755 BX472485 
    BG194979 BX471708 AI743863 BI549404 BX640869 AI650349 AK022900 AA250932 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MANEA    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
    SP1:              -     -                     
    SP2:                                          


    ECgene alternative splicing isoforms for MANEA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MANEA expression in normal human tissues (normalized intensities)      MANEA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MANEA Expression
    About this image


    MANEA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Primitive Streak (Early Embryonic Tissues)
             Mesendoderm-like cells ( Generation of mesendoderm and definitive endoderm cells...
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical cord blood-derived endothelial progenitor cells
     
     Endothelium (Cardiovascular System)
             Umbilical cord blood-derived endothelial progenitor cells
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)

    See MANEA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MANEA

    SOURCE GeneReport for Unigene clusters: Hs.734632 Hs.743412

    UniProtKB/Swiss-Prot: MANEA_HUMAN, Q5SRI9
    Tissue specificity: Highly expressed in the liver and kidney. Expressed at lower levels in muscle, pancreas,
    heart, placenta, lung and brain

        SABiosciences Custom PCR Arrays for MANEA
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MANEA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MANEA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MANEA gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Manea1 , 5 mannosidase, endo-alpha1, 5 85.5(n)1
    85.5(a)1
      4 (10.92 cM)5
    2423621  NM_172865.21  NP_766453.21 
     263245065 
    chicken
    (Gallus gallus)
    Aves MANEA1 mannosidase, endo-alpha 72.63(n)
    72.19(a)
      421807  XM_419831.3  XP_419831.2 
    lizard
    (Anolis carolinensis)
    Reptilia MANEA6
    Uncharacterized protein
    72(a)
    1 ↔ 1
    1(179956996-179965755)
    zebrafish
    (Danio rerio)
    Actinopterygii manea6
    mannosidase, endo-alpha
    58(a)
    1 ↔ 1
    17(15500106-15508447)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG140151 CG14015 42.14(n)
    29.74(a)
      33780  NM_135093.3  NP_608937.1 


    ENSEMBL Gene Tree for MANEA (if available)
    TreeFam Gene Tree for MANEA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MANEA gene
    MANEAL2  
    1 SIMAP similar gene for MANEA using alignment to 1 protein entry:     MANEA_HUMAN:
    MANEAL

    MANEA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/671 SNPs in MANEA are shown (see all 671)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362424
    A breast cancer sample4--see VAR_0362422 Y C mis40--------
    rs92854131,2
    C--96023439(+) tcagcA/Gaagct 1 -- us2k110Minor allele frequency- G:0.12NA WA CSA EA 371
    rs1392544481,2
    --96023552(+) ATAAAA/CCTAGG 1 -- us2k10--------
    rs1891437251,2
    --96023563(+) AGGCAA/GTATAA 1 -- us2k10--------
    rs1499720711,2
    --96023633(+) ATATAC/TCATGT 1 -- us2k10--------
    rs69373021,2
    C,F,A--96023655(+) AAGACG/ATTTCA 1 -- us2k110Minor allele frequency- A:0.31NA WA CSA EA 372
    rs132059221,2
    C--96023692(+) TTGAAT/AAAAAT 1 -- us2k13Minor allele frequency- A:0.09NA EA 242
    rs69374791,2
    C,F,A,H--96023755(+) TTTCAT/ATGAAA 1 -- us2k114Minor allele frequency- A:0.39NS EA NA WA CSA 848
    rs1165530881,2
    C,F--96023757(+) TCAATG/CAAAGA 1 -- us2k11Minor allele frequency- C:0.09WA 118
    rs624178101,2
    C--96023779(+) AGTATA/GGTTAA 1 -- us2k13Minor allele frequency- G:0.07NA EA 242

    HapMap Linkage Disequilibrium report for MANEA (96025373 - 96057333 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for MANEA:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2656633CNV Deletion23128226
    esv2667481CNV Deletion23128226
    nsv518549CNV Loss19592680
    nsv886418CNV Loss21882294
    nsv463980CNV Loss19166990
    nsv819429CNV Gain19587683
    nsv886419CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612327    OMIM disorders: --

    4 diseases for MANEA:    About MalaCards
    dracunculiasis    substance dependence    cocaine dependence    down syndrome

    2 diseases from the University of Copenhagen DISEASES database for MANEA:
    Dracunculiasis     Cocaine dependence

    MANEA for disorders           About GeneDecksing

    Genetic Association Database (GAD): MANEA
    Human Genome Epidemiology (HuGE) Navigator: MANEA (4 documents)

    Export disorders for MANEA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MANEA gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with MANEA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. Association of variants in MANEA with cocaine-related behaviors. (PubMed id 19255376)1, 4 Farrer L.A....Gelernter J. (2009)
    3. Substance dependence low-density whole genome association study in two distinct American populations. (PubMed id 18438686)1, 4 Yu Y....Gelernter J. (2008)
    4. Intact alpha-1,2-endomannosidase is a typical type II membrane protein. (PubMed id 15677381)1, 2 Hamilton S.R.... Gerngross T.U. (2005)
    5. Human endo-alpha1,2-mannosidase is a Golgi-resident type II membrane protein. (PubMed id 15760709)1, 2 Hardt B....Bause E. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    9. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    10. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79694 HGNC: 21072 AceView: MANEA Ensembl:ENSG00000172469 euGenes: HUgn79694
    ECgene: MANEA H-InvDB: MANEA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MANEA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MANEA gene:
    Search GeneIP for patents involving MANEA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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