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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MANEA Gene

protein-coding GIFtS: 50
GCID: GC06P096071

mannosidase, endo-alpha

Explore 3 diseases affiliated with
MANEA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mannosidase, Endo-Alpha¹ ²		Alpha 1,2-Endomannosidase²
Mandaselin³		Endomannosidase³
Endo-Alpha Mannosidase² ³		Glycoprotein Endo-Alpha-1,2-Mannosidase²
HEndo¹		Endomannosidase³
EC 3.2.1.130³ ⁸		Mandaselin³
ENDO² ⁵		EC 3.2.1⁸
FLJ12838¹

External Ids:	HGNC: 21072¹	Entrez Gene: 79694²	Ensembl: ENSG00000172469⁷	OMIM: 612327⁵	UniProtKB: Q5SRI9³

Export aliases for MANEA gene to outside databases

Previous GC identifers: GC06P096025 GC06P096132 GC06P093458

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MANEA:

N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled

oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target

protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER

glycosidases and by an endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi. MANEA catalyzes the release of

mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to

high-mannose glycans (Hamilton et al., 2005 (PubMed 15677381)).(supplied by OMIM, Sep 2008)

Gene Wiki entry for MANEA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MANEA gene promoter:
TBP LUN-1 Nkx2-5 POU3F2 Meis-1b FOXJ2 (long isoform) TFIID HSF2 Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MANEA promoter sequence

Search SABiosciences Chromatin IP Primers for MANEA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MANEA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q16.1 Ensembl cytogenetic band: 6q16.1 HGNC cytogenetic band: 6q16.2

MANEA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MANEA gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P096071: view genomic region (about GC identifiers)

Start:	96,025,413 bp from pter	End:	96,057,333 bp from pter
Size:	31,921 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MANEA_HUMAN, Q5SRI9 (See protein sequence)

Recommended Name: Glycoprotein endo-alpha-1,2-mannosidase

Size: 462 amino acids; 53671 Da

Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein

Sequence caution: Sequence=AAL07306.1; Type=Frameshift; Positions=Several; Sequence=CAD97640.1; Type=Erroneous

initiation; Sequence=CAI17346.1; Type=Erroneous gene model prediction;

Secondary accessions: A6H8M6 Q5SRJ0 Q6MZV0 Q70JE9 Q7Z3V7 Q8WWX5 Q9H9D2

Explore the universe of human proteins at neXtProt for MANEA: NX_Q5SRI9

Post-translational modifications:

Undergoes proteolytic cleavage in the C-terminal region¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5SRI9

4/9 DME Specific Peptides for MANEA (Q5SRI9) (see all 9)

GSSHQNW

LLVEEKH

FRRRTCI

FIALLVEE

MANEA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_078917.2

ENSEMBL proteins:

ENSP00000358299 ENSP00000351669

Reactome Protein details: Q5SRI9
Human Recombinant Protein Products:

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	Novus Biologicals MANEA Protein Novus Biologicals MANEA Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0005794	Golgi apparatus	IDA	--
GO:0016021	integral to membrane	IEA	--

MANEA for ontologies About GeneDecksing

MANEA Antibody Products:

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	Novus Biologicals MANEA Antibodies
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	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for MANEA

Assay Products for MANEA:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for MANEA
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MANEA for domains About GeneDecksing

2 InterPro domains/families:

IPR017853 Glycoside_hydrolase_SF

IPR026071 Glyco_Hydrolase_99

Graphical View of Domain Structure for InterPro Entry Q5SRI9

ProtoNet protein and cluster: Q5SRI9

UniProtKB/Swiss-Prot: MANEA_HUMAN, Q5SRI9

Similarity: Belongs to the glycosyl hydrolase 99 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: MANEA_HUMAN, Q5SRI9

Catalytic activity: Hydrolysis of the terminal alpha-D-glucosyl-(1,3)-D-mannosyl unit from the GlcMan(9)(GlcNAc)(2)

oligosaccharide component of the glycoprotein produced in the Golgi membrane

Biophysicochemical properties: pH dependence: Optimum pH is 6.2; Temperature dependence: Optimum temperature is 37

degrees Celsius;

Enzyme Numbers (IUBMB): EC 3.2.1.130¹ ² EC 3.2.1²

miRNA Products:		OriGene 3'-UTR Clone: MANEA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MANEA
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate MANEA (see all 12):
		hsa-miR-4291 hsa-miR-4307 hsa-miR-495 hsa-miR-4251 hsa-miR-539 hsa-miR-7-2* hsa-miR-586 hsa-miR-3921

		SwitchGear 3'UTR luciferase reporter plasmid: MANEA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MANEA (see all 7) OriGene shRNA RFP: MANEA OriGene siRNA: MANEA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MANEA

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for MANEA

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MANEA (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MANEA OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MANEA (NM_024641)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MANEA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MANEA

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MANEA
		Search LifeMap BioReagents cell lines for MANEA

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MANEA

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004559	alpha-mannosidase activity	--	--
GO:0004569	glycoprotein endo-alpha-1,2-mannosidase activity	IEA	--

MANEA for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for MANEA:

Decreased viability with pacli

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Asparagine N-linked glycosylation

	Asparagine N-linked glycosylation	1.00			Metabolism of proteins	0.15
	Post-translational protein modification	0.44

N-glycan trimming and elongation in the cis-Golgi

N-glycan trimming and elongation in the cis-Golgi

1.00

N-glycan antennae elongation in the medial/trans-Golgi

Transport to the Golgi and subsequent modification

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for MANEA

	Transport to the Golgi and subsequent modification
	Asparagine N-linked glycosylation
	Metabolism of proteins
	Post-translational protein modification
	N-glycan trimming and elongation in the cis-Golgi

MANEA for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MANEA

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0018279	protein N-linked glycosylation via asparagine	TAS	--
GO:0043687	post-translational protein modification	TAS	--
GO:0044267	cellular protein metabolic process	TAS	--

MANEA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MANEA
Search CenterWatch for drugs/clinical trials and news about MANEA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MANEA gene:

NM_024641.3

Unigene Clusters for MANEA:

Mannosidase, endo-alpha

Hs.734632 [show with all ESTs], Hs.743412 [show with all ESTs]

Unigene Representative Sequences: AY048775, BC150199

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000369293(uc003pon.3) ENST00000358812(uc003poo.2) ENST00000474553

miRNA Products:		OriGene 3'-UTR Clone: MANEA Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MANEA
		8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate MANEA (see all 12):
		hsa-miR-4291 hsa-miR-4307 hsa-miR-495 hsa-miR-4251 hsa-miR-539 hsa-miR-7-2* hsa-miR-586 hsa-miR-3921

		SwitchGear 3'UTR luciferase reporter plasmid: MANEA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MANEA (see all 7) OriGene shRNA RFP: MANEA OriGene siRNA: MANEA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MANEA

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MANEA (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MANEA OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MANEA (NM_024641)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MANEA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MANEA

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MANEA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MANEA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MANEA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MANEA

Additional cDNA sequence:

AJ577574.1 AK022900.1 AK291940.1 AY048774.1 AY372528.1 BC137014.1 BC137016.1 BC146671.1

BC150199.1 BX537398.1 BX640869.1 CR936827.1

2 DOTS entries:

DT.209802 DT.70103586

24/76 AceView cDNA sequences (see all 76):

BQ018032 CD678316 AJ577574 AA826264 BF970329 AI050667 AA975408 BX472485

BX496891 AA360755 NM_024641 AA251061 BG194979 AA761166 BX102844 AW967584

BI553634 AA846588 BF968958 AI587307 BG164727 BX537398 AI079253 BG939487

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for MANEA About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7
SP1:					-		-
SP2:

ECgene alternative splicing isoforms for MANEA

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MANEA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

MANEA expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Mesendoderm-like cells (Generation of mesend...)

Definitive endoderm-like cells (A scalable, suspensi...)

Definitive Endoderm (Generation of beta c...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MANEA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MANEA

SOURCE GeneReport for Unigene clusters: Hs.734632 Hs.743412

UniProtKB/Swiss-Prot: MANEA_HUMAN, Q5SRI9

Tissue specificity: Highly expressed in the liver and kidney. Expressed at lower levels in muscle, pancreas, heart,

placenta, lung and brain

SABiosciences Custom PCR Arrays for MANEA

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MANEA Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MANEA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MANEA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MANEA gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Manea^{1 , 5}	mannosidase, endo-alpha^{1, 5}	85.5(n)¹ 85.5(a)¹		4 (10.92 cM)⁵ 242362¹ NM_172865.2¹ NP_766453.2¹ 26324506⁵
chicken (Gallus gallus)	Aves	MANEA¹	mannosidase, endo-alpha	72.63(n) 72.19(a)		421807 XM_419831.3 XP_419831.2
lizard (Anolis carolinensis)	Reptilia	MANEA⁶	--	71(a)	1 ↔ 1	1(179957029-179965755)
zebrafish (Danio rerio)	Actinopterygii	manea⁶	mannosidase, endo-alpha	58(a)	1 ↔ 1	17(15500106-15508447)
fruit fly (Drosophila melanogaster)	Insecta	CG14015¹	CG14015	42.14(n) 29.74(a)		33780 NM_135093.3 NP_608937.1

ENSEMBL Gene Tree for MANEA (if available)
TreeFam Gene Tree for MANEA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MANEA gene

MANEAL²

1 SIMAP similar gene for MANEA using alignment to 1 protein entry: MANEA_HUMAN:

MANEAL

MANEA for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9285413^1,2	C,	--	96023439(+)	`TCAGCA/GAAGCT`	1	--	us2k¹		10		NA WA CSA EA	371
rs139254448^1,2		--	96023552(+)	`ATAAAA/CCTAGG`	1	--	us2k¹		0	--	--	--	--
rs189143725^1,2		--	96023563(+)	`AGGCAA/GTATAA`	1	--	us2k¹		0	--	--	--	--
rs149972071^1,2		--	96023633(+)	`ATATAC/TCATGT`	1	--	us2k¹		0	--	--	--	--
rs6937302^1,2	C,F,A,	--	96023655(+)	`AAGACG/ATTTCA`	1	--	us2k¹		10		NA WA CSA EA	372
rs13205922^1,2	C,	--	96023692(+)	`TTGAAT/AAAAAT`	1	--	us2k¹		3		NA EA	242
rs6937479^1,2	C,F,A,H,	--	96023755(+)	`TTTCAT/ATGAAA`	1	--	us2k¹		14		NS EA NA WA CSA	848
rs116553088^1,2	F,	--	96023757(+)	`TCAATG/CAAAGA`	1	--	us2k¹		1		WA	118
rs62417810^1,2	C,	--	96023779(+)	`AGTATA/GGTTAA`	1	--	us2k¹		3		NA EA	242
rs182020893^1,2		--	96023923(+)	`ACTTGC/TAGAAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MANEA (96025413 - 96057333 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MANEA
1 CNV: 59367

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MANEA

DNA2.0 Custom Variant and Variant Library Synthesis for MANEA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MANEA for disorders           About GeneDecksing

OMIM gene information: 612327    OMIM disorders: --

3 diseases for MANEA:    About MalaCards

substance dependence dracunculiasis immunodeficiency

2 diseases from the University of Copenhagen DISEASES database for MANEA:

Dracunculiasis Cocaine dependence

Human Genome Epidemiology (HuGE) Navigator: MANEA (4 documents)

Export disorders for MANEA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MANEA gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with MANEA)

Utopia: connect your pdf to the dynamic
world of online information

Intact alpha-1,2-endomannosidase is a typical type II membrane protein. (PubMed id 15677381)^{1, 2} Hamilton S.R.... Gerngross T.U. (2005)
Human endo-alpha1,2-mannosidase is a Golgi-resident type II membrane protein. (PubMed id 15760709)^{1, 2} Hardt B....Bause E. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Association of variants in MANEA with cocaine-related behaviors. (PubMed id 19255376)¹ Farrer L.A....Gelernter J. (2009)
Substance dependence low-density whole genome association study in two distinct American populations. (PubMed id 18438686)¹ Yu Y....Gelernter J. (2008)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Phosphorylation of amphiphysin I by minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase, a kinase implicated in Down syndrome. (PubMed id 16733250)¹ Murakami N....Hwang Y.W. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 79694	HGNC: 21072	AceView: MANEA	Ensembl:ENSG00000172469	euGenes: HUgn79694
ECgene: MANEA	H-InvDB: MANEA

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MANEA	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MANEA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MANEA gene:
Search GeneIP for patents involving MANEA

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MANEA

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MANEA

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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MANEA Gene

mannosidase, endo-alpha

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MANEA Gene

mannosidase, endo-alpha

Aliasesfor MANEA gene

Summariesfor MANEA gene

Genomic Viewsfor MANEA gene

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Protein Domains /Familiesfor MANEA gene

Functionfor MANEA gene

Pathways & Interactionsfor MANEA gene

Drugs & Compoundsfor MANEA gene

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Expression for MANEA gene

Orthologsfor MANEA gene

Paralogsfor MANEA gene

Genomic Variantsfor MANEA gene

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External Searches for MANEA gene

Genome Databases showing MANEA gene

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Specialized Databases showing MANEA gene

Intellectual Propertyfor MANEA gene

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for MANEA gene

Summaries
for MANEA gene

Genomic Views
for MANEA gene

Proteins
for MANEA gene

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Families
for MANEA gene

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for MANEA gene

Pathways & Interactions
for MANEA gene

Drugs & Compounds
for MANEA gene

Transcripts
for MANEA gene

Expression
for MANEA gene

Orthologs
for MANEA gene

Paralogs
for MANEA gene

Genomic Variants
for MANEA gene

Disorders / Diseases
for MANEA gene

Publications
for MANEA gene

Intellectual Property
for MANEA gene

Products
for MANEA gene