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Aliases for MANEA Gene

Aliases for MANEA Gene

  • Mannosidase, Endo-Alpha 2 3
  • Endo-Alpha Mannosidase 3 4
  • Endomannosidase 3 4
  • EC 4 63
  • Mandaselin 3 4
  • HEndo 3 4
  • Alpha 1,2-Endomannosidase 3
  • EC 3.2.1 63
  • ENDO 3

External Ids for MANEA Gene

Previous GeneCards Identifiers for MANEA Gene

  • GC06P096025
  • GC06P096071
  • GC06P096132
  • GC06P093458

Summaries for MANEA Gene

Entrez Gene Summary for MANEA Gene

  • N-glycosylation of proteins is initiated in the endoplasmic reticulum (ER) by the transfer of the preassembled oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from dolichyl pyrophosphate to acceptor sites on the target protein by an oligosaccharyltransferase complex. This core oligosaccharide is sequentially processed by several ER glycosidases and by an endomannosidase (E.C., such as MANEA, in the Golgi. MANEA catalyzes the release of mono-, di-, and triglucosylmannose oligosaccharides by cleaving the alpha-1,2-mannosidic bond that links them to high-mannose glycans (Hamilton et al., 2005 [PubMed 15677381]).[supplied by OMIM, Sep 2008]

GeneCards Summary for MANEA Gene

MANEA (Mannosidase, Endo-Alpha) is a Protein Coding gene. Diseases associated with MANEA include dracunculiasis and substance dependence. Among its related pathways are Transport to the Golgi and subsequent modification. GO annotations related to this gene include alpha-mannosidase activity and glycoprotein endo-alpha-1,2-mannosidase activity. An important paralog of this gene is MANEAL.

Gene Wiki entry for MANEA Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MANEA Gene

Genomics for MANEA Gene

Regulatory Elements for MANEA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MANEA Gene

95,577,497 bp from pter
95,609,457 bp from pter
31,961 bases
Plus strand

Genomic View for MANEA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MANEA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MANEA Gene

Proteins for MANEA Gene

  • Protein details for MANEA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Glycoprotein endo-alpha-1,2-mannosidase
    Protein Accession:
    Secondary Accessions:
    • A6H8M6
    • Q5SRJ0
    • Q6MZV0
    • Q70JE9
    • Q7Z3V7
    • Q8WWX5
    • Q9H9D2

    Protein attributes for MANEA Gene

    462 amino acids
    Molecular mass:
    53671 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAL07306.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=CAD97640.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI17346.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for MANEA Gene

Proteomics data for MANEA Gene at MOPED

Post-translational modifications for MANEA Gene

  • Undergoes proteolytic cleavage in the C-terminal region
  • Glycosylation at Thr 73 and Ser 78
  • Modification sites at PhosphoSitePlus

Other Protein References for MANEA Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MANEA Gene

Gene Families for MANEA Gene

Protein Domains for MANEA Gene

Suggested Antigen Peptide Sequences for MANEA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 99 family.
  • Belongs to the glycosyl hydrolase 99 family.
genes like me logo Genes that share domains with MANEA: view

Function for MANEA Gene

Molecular function for MANEA Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.2. {ECO:0000269 PubMed:15677381}; Temperature dependence: Optimum temperature is 37 degrees Celsius. {ECO:0000269 PubMed:15677381};
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of the terminal alpha-D-glucosyl-(1,3)-D-mannosyl unit from the GlcMan(9)(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane.

Enzyme Numbers (IUBMB) for MANEA Gene

Gene Ontology (GO) - Molecular Function for MANEA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004559 alpha-mannosidase activity --
GO:0004569 glycoprotein endo-alpha-1,2-mannosidase activity IEA --
genes like me logo Genes that share ontologies with MANEA: view

Phenotypes for MANEA Gene

GenomeRNAi human phenotypes for MANEA:
genes like me logo Genes that share phenotypes with MANEA: view

Animal Model Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for MANEA Gene

Localization for MANEA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MANEA Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for MANEA Gene COMPARTMENTS Subcellular localization image for MANEA gene
Compartment Confidence
golgi apparatus 4

Gene Ontology (GO) - Cellular Components for MANEA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MANEA: view

Pathways & Interactions for MANEA Gene

genes like me logo Genes that share pathways with MANEA: view

Interacting Proteins for MANEA Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000351669 for MANEA Gene via STRING

Gene Ontology (GO) - Biological Process for MANEA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MANEA: view

No data available for SIGNOR curated interactions for MANEA Gene

Drugs & Compounds for MANEA Gene

No Compound Related Data Available

Transcripts for MANEA Gene

Unigene Clusters for MANEA Gene

Mannosidase, endo-alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MANEA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: - -

Relevant External Links for MANEA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MANEA Gene

mRNA expression in normal human tissues for MANEA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MANEA Gene

This gene is overexpressed in Islet of Langerhans (48.6) and Ovary (20.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MANEA Gene

SOURCE GeneReport for Unigene cluster for MANEA Gene Hs.734632

mRNA Expression by UniProt/SwissProt for MANEA Gene

Tissue specificity: Highly expressed in the liver and kidney. Expressed at lower levels in muscle, pancreas, heart, placenta, lung and brain.
genes like me logo Genes that share expression patterns with MANEA: view

Protein tissue co-expression partners for MANEA Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MANEA Gene

Orthologs for MANEA Gene

This gene was present in the common ancestor of animals.

Orthologs for MANEA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MANEA 35
  • 87.38 (n)
  • 83.81 (a)
  • 83 (a)
(Canis familiaris)
Mammalia MANEA 35
  • 89.37 (n)
  • 85.47 (a)
  • 85 (a)
(Mus musculus)
Mammalia Manea 35
  • 85.5 (n)
  • 85.5 (a)
Manea 16
Manea 36
  • 85 (a)
(Pan troglodytes)
Mammalia MANEA 35
  • 99.28 (n)
  • 98.7 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Manea 35
  • 84.92 (n)
  • 85.5 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
(Gallus gallus)
Aves MANEA 35
  • 72.55 (n)
  • 72.19 (a)
-- 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485932 35
  • 69.2 (n)
  • 66.67 (a)
(Danio rerio)
Actinopterygii manea 35
  • 61.16 (n)
  • 59.17 (a)
manea 36
  • 58 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011905 35
  • 47.4 (n)
  • 38.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14015 35
  • 43 (n)
  • 30.53 (a)
CG14015 36
  • 23 (a)
Species with no ortholog for MANEA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MANEA Gene

Gene Tree for MANEA (if available)
Gene Tree for MANEA (if available)

Paralogs for MANEA Gene

Paralogs for MANEA Gene

(1) SIMAP similar genes for MANEA Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MANEA: view

Variants for MANEA Gene

Sequence variations from dbSNP and Humsavar for MANEA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1133503 -- 95,606,712(+) TTGTG(C/T)TACCT utr-variant-3-prime
rs3087829 -- 95,587,005(-) ACACA(C/T)ATATA intron-variant
rs4256442 -- 95,580,903(+) AGGCA(C/T)TTAGA intron-variant
rs4302677 -- 95,603,300(+) ATGTA(A/T)CTGAA intron-variant
rs4368819 -- 95,583,233(+) ATGGG(G/T)AAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MANEA Gene

Variant ID Type Subtype PubMed ID
nsv463980 CNV Loss 19166990
nsv886418 CNV Loss 21882294
nsv518549 CNV Loss 19592680
nsv886419 CNV Gain 21882294
esv2656633 CNV Deletion 23128226
esv2667481 CNV Deletion 23128226
nsv819429 CNV Gain 19587683

Variation tolerance for MANEA Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.67; 78.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MANEA Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MANEA Gene

Disorders for MANEA Gene

MalaCards: The human disease database

(2) MalaCards diseases for MANEA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • infection by dracunculus medinensis
substance dependence
- elite association
Search MANEA in MalaCards View complete list of genes associated with diseases

Relevant External Links for MANEA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MANEA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MANEA Gene

Publications for MANEA Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. The I+-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder. (PMID: 24473444) Jensen K.P. … Gelernter J. (Transl Psychiatry 2014) 67
  3. Deletion of the highly conserved N-glycan at Asn260 of HIV-1 gp120 affects folding and lysosomal degradation of gp120, and results in loss of viral infectivity. (PMID: 24967714) Mathys L. … Balzarini J. (PLoS ONE 2014) 67
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  5. Association of variants in MANEA with cocaine-related behaviors. (PMID: 19255376) Farrer L.A. … Gelernter J. (Arch. Gen. Psychiatry 2009) 67

Products for MANEA Gene

Sources for MANEA Gene

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