Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MANBAL Gene

Aliases for MANBAL Gene

  • Mannosidase Beta Like 2 3
  • Mannosidase, Beta A, Lysosomal-Like 2 5
  • Mannosidase Beta A Like 2

External Ids for MANBAL Gene

Previous GeneCards Identifiers for MANBAL Gene

  • GC20P035653
  • GC20P036556
  • GC20P036603
  • GC20P035351
  • GC20P035918
  • GC20P032653

Summaries for MANBAL Gene

GeneCards Summary for MANBAL Gene

MANBAL (Mannosidase Beta Like) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MANBAL Gene

Genomics for MANBAL Gene

Regulatory Elements for MANBAL Gene

Promoters for MANBAL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MANBAL on UCSC Golden Path with GeneCards custom track

Genomic Location for MANBAL Gene

Chromosome:
20
Start:
37,289,638 bp from pter
End:
37,317,260 bp from pter
Size:
27,623 bases
Orientation:
Plus strand

Genomic View for MANBAL Gene

Genes around MANBAL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MANBAL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MANBAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MANBAL Gene

Proteins for MANBAL Gene

  • Protein details for MANBAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQG1-MANBL_HUMAN
    Recommended name:
    Protein MANBAL
    Protein Accession:
    Q9NQG1
    Secondary Accessions:
    • A8KAA6
    • E1P5V3

    Protein attributes for MANBAL Gene

    Size:
    85 amino acids
    Molecular mass:
    9467 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MANBAL Gene

Proteomics data for MANBAL Gene at MOPED

Post-translational modifications for MANBAL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MANBAL Gene

No data available for DME Specific Peptides for MANBAL Gene

Domains & Families for MANBAL Gene

Gene Families for MANBAL Gene

Protein Domains for MANBAL Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MANBAL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQG1

UniProtKB/Swiss-Prot:

MANBL_HUMAN :
  • Belongs to the UPF0239 family.
Family:
  • Belongs to the UPF0239 family.
genes like me logo Genes that share domains with MANBAL: view

Function for MANBAL Gene

genes like me logo Genes that share phenotypes with MANBAL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MANBAL

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MANBAL Gene

Localization for MANBAL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MANBAL Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MANBAL Gene COMPARTMENTS Subcellular localization image for MANBAL gene
Compartment Confidence
mitochondrion 3
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for MANBAL Gene

Pathways & Interactions for MANBAL Gene

SuperPathways for MANBAL Gene

No Data Available

Interacting Proteins for MANBAL Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362707%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000365576%0d%0a
Selected Interacting proteins: Q9NQG1-MANBL_HUMAN ENSP00000362707 for MANBAL Gene via I2D UniProtKB STRING

Gene Ontology (GO) - Biological Process for MANBAL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MANBAL Gene

Drugs & Compounds for MANBAL Gene

No Compound Related Data Available

Transcripts for MANBAL Gene

Unigene Clusters for MANBAL Gene

Mannosidase, beta A, lysosomal-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MANBAL Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - -
SP2: -
SP3: - - - - - -
SP4: - - -
SP5: -
SP6: - - - - - - -
SP7: -

Relevant External Links for MANBAL Gene

GeneLoc Exon Structure for
MANBAL
ECgene alternative splicing isoforms for
MANBAL

Expression for MANBAL Gene

mRNA expression in normal human tissues for MANBAL Gene

Protein differential expression in normal tissues from HIPED for MANBAL Gene

This gene is overexpressed in Nasal epithelium (65.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MANBAL Gene



SOURCE GeneReport for Unigene cluster for MANBAL Gene Hs.6126

genes like me logo Genes that share expression patterns with MANBAL: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MANBAL Gene

Orthologs for MANBAL Gene

This gene was present in the common ancestor of chordates.

Orthologs for MANBAL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MANBAL 35
  • 88.29 (n)
  • 93.24 (a)
MANBAL 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MANBAL 35
  • 89.19 (n)
  • 90.54 (a)
MANBAL 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Manbal 35
  • 87.84 (n)
  • 86.49 (a)
Manbal 16
Manbal 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MANBAL 35
  • 99.22 (n)
  • 98.82 (a)
MANBAL 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Manbal 35
  • 87.84 (n)
  • 91.89 (a)
oppossum
(Monodelphis domestica)
Mammalia MANBAL 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MANBAL 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 45 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia MANBAL 36
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii MANBAL 36
  • 57 (a)
OneToOne
Species with no ortholog for MANBAL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MANBAL Gene

ENSEMBL:
Gene Tree for MANBAL (if available)
TreeFam:
Gene Tree for MANBAL (if available)

Paralogs for MANBAL Gene

Pseudogenes.org Pseudogenes for MANBAL Gene

genes like me logo Genes that share paralogs with MANBAL: view

No data available for Paralogs for MANBAL Gene

Variants for MANBAL Gene

Sequence variations from dbSNP and Humsavar for MANBAL Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1806940 -- 37,316,771(+) CATTT(G/T)GGAGT utr-variant-3-prime
rs1043404 -- 37,316,701(+) ACAGA(A/G)TCACA utr-variant-3-prime
rs1043415 -- 37,316,835(+) CTCCT(C/G)CTGAT utr-variant-3-prime
rs1043432 -- 37,316,940(+) AGCTG(C/T)GACAG utr-variant-3-prime
rs1043453 -- 37,316,993(+) AGGCC(A/G)GGGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MANBAL Gene

Variant ID Type Subtype PubMed ID
nsv524059 CNV Loss 19592680
nsv509767 CNV Insertion 20534489
nsv470551 CNV Gain 18288195

Variation tolerance for MANBAL Gene

Residual Variation Intolerance Score: 63.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MANBAL Gene

HapMap Linkage Disequilibrium report
MANBAL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MANBAL Gene

Disorders for MANBAL Gene

Relevant External Links for MANBAL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MANBAL

No disorders were found for MANBAL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MANBAL Gene

Publications for MANBAL Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PMID: 21078624) Kahle J.J. … Zoghbi H.Y. (Hum. Mol. Genet. 2011) 3
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for MANBAL Gene

Sources for MANBAL Gene

Back to Top

Content