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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MANBA Gene

protein-coding   GIFtS: 57
GCID: GC04M103552

mannosidase, beta A, lysosomal
 Explore 17 diseases affiliated with
MANBA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MANBA    

Aliases
for MANBA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mannosidase, Beta A, Lysosomal1 2     Mannanase3
MANB12 3 5     Mannase3
Lysosomal Beta A Mannosidase2 3     Mannanase3
EC 3.2.1.253 8     Mannase3
Beta-Mannosidase1     

External Ids:    HGNC: 68311   Entrez Gene: 41262   Ensembl: ENSG000001093237   OMIM: 6094895   UniProtKB: O004623   

Export aliases for MANBA gene to outside databases

Previous GC identifers: GC04M103951 GC04M104011 GC04M103909 GC04M103771 GC04M099288


Summaries
for MANBA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MANBA:
This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it
is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this
gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological
involvement. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MANBA_HUMAN, O00462
Function: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked
glycoprotein oligosaccharides

Gene Wiki entry for MANBA (Beta-mannosidase)


Genomic Views
for MANBA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MANBA gene promoter:
         LHX3b/Lhx3b   p53   Sp1   Nkx2-2   Pax-6   POU3F2   Nkx6-1   Ik-2   SEF-1 (1)   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MANBA promoter sequence
   Search SABiosciences Chromatin IP Primers for MANBA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MANBA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22-q25   Ensembl cytogenetic band:  4q24   HGNC chromosome: 4

MANBA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MANBA gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M103552:  view genomic region     (about GC identifiers)

Start:
 103,552,643 bp from pter      End:
 103,682,151 bp from pter
Size:
 129,509 bases      Orientation:
 minus strand

Proteins
for MANBA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MANBA_HUMAN, O00462 (See protein sequence)
Recommended Name: Beta-mannosidase precursor  
Size: 879 amino acids; 100895 Da
Subcellular location: Lysosome
Secondary accessions: Q96BC3 Q9NYX9

Explore the universe of human proteins at neXtProt for MANBA: NX_O00462

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00462

    • 4/7 DME Specific Peptides for MANBA (O00462) (see all 7)
     KTETEFY  DYVTLYVK  AKVYFRTV  MFACALYPT 

    MANBA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005899.3  
    ENSEMBL proteins: 
     ENSP00000226578   ENSP00000427322   ENSP00000422001  

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    Novus Biologicals MANBA Protein
    Novus Biologicals MANBA Lysates
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005764lysosome IEA--


    MANBA for ontologies           About GeneDecksing



    MANBA Antibody Products: 
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    Protein Domains /
    Families
    for MANBA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MANBA for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR017853 Glycoside_hydrolase_SF
     IPR008979 Galactose-bd-like
     IPR013812 Glyco_hydro_2/20_Ig-like
     IPR013781 Glyco_hydro_catalytic_dom
     IPR006103 Glyco_hydro_2_TIM

    Graphical View of Domain Structure for InterPro Entry O00462

    ProtoNet protein and cluster: O00462

    UniProtKB/Swiss-Prot: MANBA_HUMAN, O00462
    Similarity: Belongs to the glycosyl hydrolase 2 family


    Function
    for MANBA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MANBA_HUMAN, O00462
    Function: Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked
    glycoprotein oligosaccharides
    Catalytic activity: Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides

         Genatlas biochemistry entry for MANBA:
    mannosidase beta A isoform,100kDa,lysosomal,expressed in pancreas,kidney,placenta

    Enzyme Number (IUBMB): EC 3.2.1.251 2

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MANBA
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MANBA:
    hsa-miR-4297 hsa-miR-181a-2* hsa-miR-1224-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MANBA 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MANBA (see all 7)
    OriGene shRNA RFP: MANBA
    OriGene siRNA: MANBA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MANBA

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MANBA

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MANBA 

    Cell Line
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    Search LifeMap BioReagents cell lines for MANBA

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MANBA

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004553hydrolase activity, hydrolyzing O-glycosyl compounds ----
    GO:0004567beta-mannosidase activity IEA--
    GO:0005537mannose binding IEA--
    GO:0043169cation binding IEA--


    MANBA for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MANBA:
     Decreased TP53 protein express 

    Animal Models:
         Mouse knock-out Manbatm1Khf for MANBA
         11 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Manba):
     behavior/neurological  cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland 
     hematopoietic system  immune system  liver/biliary system  nervous system  renal/urinary system 
     reproductive system 

    MANBA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MANBA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Other glycan degradation
    		Other glycan degradation1.00
    2Lysosome
    		Lysosome1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for MANBA):
        Other glycan degradation
    Lysosome

    UniProtKB/Swiss-Prot: MANBA_HUMAN, O00462
    Pathway: Glycan metabolism; N-glycan degradation


    MANBA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MANBA

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for MANBA (ENSP000002265784) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    DNAJC3ENSP000003659914STRING: ENSP00000365991
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IEA--
    GO:0006464cellular protein modification process NAS9384606
    GO:0006516glycoprotein catabolic process IEA--


    MANBA for ontologies           About GeneDecksing



    Drugs & Compounds
    for MANBA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MANBA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MANBA
    4 Novoseek chemical compound relationships for MANBA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mannan 75.4 2 16175204 (1), 17068754 (1)
    mannose 40.4 3 9335173 (1), 19441796 (1)
    polysaccharide 30.2 1 11702407 (1)
    cellulose 23.9 1 16175204 (1)

    Search CenterWatch for drugs/clinical trials and news about MANBA 

    Transcripts
    for MANBA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MANBA gene: 
    NM_005908.3  

    Unigene Cluster for MANBA:

    Mannosidase, beta A, lysosomal
    Hs.480415  [show with all ESTs]
    Unigene Representative Sequence: NM_005908
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514430(uc003hwg.3 uc011ces.2) ENST00000226578 ENST00000505239
    ENST00000508141 ENST00000506478 ENST00000511813 ENST00000507358

    miRNA
    Products:             		 OriGene 3'-UTR Clone: MANBA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MANBA
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate MANBA:
    hsa-miR-4297 hsa-miR-181a-2* hsa-miR-1224-5p
    SwitchGear 3'UTR luciferase reporter plasmid: MANBA 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MANBA (see all 7)
    OriGene shRNA RFP: MANBA
    OriGene siRNA: MANBA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MANBA
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MANBA
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: MANBA (NM_005908)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MANBA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MANBA 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MANBA
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MANBA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MANBA

    Additional cDNA sequence: 

    AK291598.1 AK300015.1 AK312827.1 BC015743.1 EU009130.1 U60337.1 

    13 DOTS entries:

    DT.211061  DT.86849091  DT.86845965  DT.92039445  DT.95179208  DT.100666605  DT.100717022  DT.101960940 
    DT.121244335  DT.121244346  DT.121244359  DT.86838949  DT.95373098 

    24/79 AceView cDNA sequences (see all 79):

    AW130191 AU132611 BE167799 AU124517 BX283800 Z42440 U60337 BX474024 
    AI079197 CD370027 BP357245 AA582086 NM_005908 CD514822 CR596300 BF940213 
    AA985442 BX389814 BG681353 AI678583 CF131178 AI655603 AI423263 CF123343 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MANBA    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c
    SP1:                                      -                                                                       -                     
    SP2:                                                                                                              -                     
    SP3:                                                                                                                                    


    ECgene alternative splicing isoforms for MANBA

    Expression
    for MANBA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MANBA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAAATTATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See MANBA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MANBA

    SOURCE GeneReport for Unigene cluster: Hs.480415
        SABiosciences Expression via Pathway-Focused PCR Arrays including MANBA: 
              Glycosylation in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for MANBA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MANBA gene from 8/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Manba1 , 5 mannosidase, beta A, lysosomal1, 5 77.93(n)1
    75.65(a)1    		   3 (62.65 cM)5
    1101731  NM_027288.31  NP_081564.31 
     1354856115 
    chicken
    (Gallus gallus)    		 Aves MANBA1 mannosidase, beta A, lysosomal 71.14(n)
    69.11(a)    		   422712  XM_420666.2  XP_420666.2 
    African clawed frog
    (Xenopus laevis)    		 Amphibia CF287510.12   -- 68.94(n)    CF287510.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc554932 similar to mannosidase, beta A, lysosomal 72.54(n)   393128  BC045360.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG125821 , 3 beta-mannosidase3
    CG125821    		 38(a)3
    46.34(n)1
    38.88(a)1    		   82A13
    405241  NM_141179.31  NP_649436.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea C33G3.41 , 3 beta-mannosidase3
    Protein C33G3.41    		 33(a)3
    46.2(n)1
    35.54(a)1    		   X(14106424-14111421)3
    1815171  NM_077941.41  NP_510342.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G090106
    		 mannosylglycoprotein endo-beta-mannosidase subunit...
    		 15(a)
    		 1 ↔ 1
    		 1(2895166-2899384)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 mannosylglycoprotein endo-beta-mannosidase, putati...
    		 14(a)
    		 1 ↔ 1
    		 5(18948361-18957255)


    ENSEMBL Gene Tree for MANBA (if available)
    TreeFam Gene Tree for MANBA (if available) 

    Paralogs
    for MANBA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for MANBA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MANBA
         1 CNV: 92277
    Human Gene Mutation Database (HGMD): MANBA
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MANBA
    DNA2.0 Custom Variant and Variant Library Synthesis for MANBA

    Disorders / Diseases
    for MANBA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MANBA for disorders           About GeneDecksing

    OMIM gene information: 609489   
    OMIM disorders: 248510  
    UniProtKB/Swiss-Prot: MANBA_HUMAN, O00462
  • Note=Defects in MANBA are the cause of a mild disorder that affects peripheral and central nervous system
    • myelin
  • Defects in MANBA are the cause of lysosomal beta A-mannosidosis (MANSB) [MIM:248510]. Autosomal recessive
    • lysosomal storage disease of glycoprotein catabolism. Clinical features are heterogeneous with a wide range of
    symptoms and age of onset. The disease is associated with a range of neurological involvement, including various
    degrees of mental retardation in most of the cases, hearing loss and speech impairment, hypotonia, epilepsy and
    peripheral neuropathy. Affected individuals have a profound reduction in beta-mannosidase activity in plasma,
    fibroblasts and leukocytes

    17 diseases for MANBA:    About MalaCards
    beta-mannosidosis    lysosomal storage disease    mannosidosis    hereditary fructose intolerance syndrome
    fructose intolerance    mannosidase deficiency disease    angiokeratoma    spinocerebellar ataxia
    alcohol dependence    peripheral neuropathy    fabry disease    neuropathy
    hypotonia    ataxia    alcoholism    colorectal cancer
    immunodeficiency

    4 diseases from the University of Copenhagen DISEASES database for MANBA:
    beta-mannosidosis     Angiokeratoma     Gastric dilatation     alpha-mannosidosis
    Genatlas disease: MANBA
    mannosidosis beta,characterized by a range of neurological involvement with mental retardation,angiokeratoma,facial
    dysmorphism,skeletal abnormalities

    Human Genome Epidemiology (HuGE) Navigator: MANBA (4 documents)

    Export disorders for MANBA gene to outside databases

    Publications
    for MANBA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MANBA gene, integrated from 9 sources (see all 67):
    (articles sorted by number of sources associating them with MANBA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Human beta-mannosidase cDNA characterization and first identification of a mutation associated with human beta-mannosidosis. (PubMed id 9384606)1, 2 Alkhayat A.H....Friderici K.H. (1998)
    3. Molecular cloning and characterization of bovine beta-mannosidase. (PubMed id 7876128)1, 3 Chen H....Friderici K.H. (1995)
    4. A MANBA mutation resulting in residual beta-mannosida se activity associated with severe leukoencephalopathy: a possible pseudodefici ency variant. (PubMed id 19728872)1, 9 Sabourdy F....Levade T. (2009)
    5. MANBA polymorphism was related to increased risk of colorectal cancer in Swedish but not in Chinese populations. (PubMed id 17899454)1, 9 Gao J....Sun X.F. (2007)
    6. Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)1  ....Compston A. (2011)
    7. A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1 Kalsi G....Riley B.P. (2010)
    8. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1 Flachsbart F....Nebel A. (2010)
    9. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1 Hosgood H.D....Lan Q. (2009)
    10. Env length and N-linked glycosylation following transm ission of human immunodeficiency virus Type 1 subtype B viruses. (PubMed id 18314154)1 Liu Y....Mullins J.I. (2008)

    External Searches for MANBA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing MANBA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4126 HGNC: 6831 AceView: MANBA Ensembl:ENSG00000109323 euGenes: HUgn4126
    ECgene: MANBA Kegg: 4126 H-InvDB: MANBA

    Other Databases showing MANBA gene

    (According to HUGE)
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    Specialized Databases showing MANBA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MANBA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MANBA Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MANBA

    Intellectual Property
    for MANBA gene

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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for MANBA gene:
    Search GeneIP for patents involving MANBA

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