Aliases for MANBA Gene
External Ids for MANBA Gene
Previous GeneCards Identifiers for MANBA Gene
This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement. [provided by RefSeq, Jul 2008]
GeneCards Summary for MANBA Gene
MANBA (Mannosidase Beta) is a Protein Coding gene. Diseases associated with MANBA include Mannosidosis, Beta and Mannosidosis. Among its related pathways are Lysosome and Metabolism. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds and beta-mannosidase activity.
UniProtKB/Swiss-Prot for MANBA Gene
Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.