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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAN2C1 Gene

protein-coding   GIFtS: 56
GCID: GC15M075648

mannosidase, alpha, class 2C, member 1


(Previous symbols: MANA1, MANA)
 Explore 11 diseases affiliated with
MAN2C1 via our new
 Human Malady Compendium 
Biological research products
for MAN2C1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mannosidase, Alpha, Class 2C, Member 11 2     MAN6A82
MANA1 2 3 5     Alpha-Mannosidase 2C12
MANA11 2 3     Mannosidase, Alpha 6A82
Alpha Mannosidase 6A8B2 3     Mannosidase, Alpha A, Cytoplasmic2
Alpha-D-Mannoside Mannohydrolase2 3     Mannosidase Alpha Class 2C Member 13
EC 3.2.1.243 8     

External Ids:    HGNC: 68271   Entrez Gene: 41232   Ensembl: ENSG000001404007   OMIM: 1545805   UniProtKB: Q9NTJ43   

Export aliases for MAN2C1 gene to outside databases

Previous GC identifers: GC15M071525 GC15M068739 GC15M073224 GC15M073363 GC15M073435 GC15M052406


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

summary for MAN2C1:
Mannosidases are divided into two subtypes; I and II, (EC numbers 3.2.1.113 and 3.2.1.114 respectively)
which display a wide expression pattern. Mannosidase I hydrolyzes (1,2)-linked alpha-D-mannose residues in
the oligo-mannose oligosaccharide Man9(GlcNAc)2 and mannosidase II hydrolyzes (1,3)- and (1,6)-linked
alpha-D-mannose residues in Man5(GlcNAc)3. Both subtypes require a divalent cation cofactor. Mutations in
mannosidases can cause mannosidosis (mannosidase I deficiency).




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAN2C1 gene promoter:
         E2F-4   E2F-3a   E2F-5   GATA-3   E2F-2   E2F   E2F-1   HSF2   STAT3   ARP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAN2C1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAN2C1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAN2C1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q11-q13   Ensembl cytogenetic band:  15q24.2   HGNC cytogenetic band: 15q11-qter

MAN2C1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAN2C1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M075648:  view genomic region     (about GC identifiers)

Start:
75,648,133 bp from pter      End:
75,660,971 bp from pter
Size:
12,839 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MA2C1_HUMAN, Q9NTJ4 (See protein sequence)
Recommended Name: Alpha-mannosidase 2C1  
Size: 1040 amino acids; 115835 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Sequence caution: Sequence=AAC00190.2; Type=Frameshift; Positions=1013; Sequence=AAC00568.1; Type=Frameshift;
Positions=1013;
Secondary accessions: Q13358 Q9UL64

Explore the universe of human proteins at neXtProt for MAN2C1: NX_Q9NTJ4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NTJ4

  • 4/5 DME Specific Peptides for MAN2C1 (Q9NTJ4) (see all 5)
     KFLKVEFP  RPTHYNTSWD  CHIDTAWLWPF  LPDTFGYSAQLPQ 

    MAN2C1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001243423.1  NP_001243424.1  NP_001243425.1  NP_006706.2  

    ENSEMBL proteins: 
     ENSP00000455998   ENSP00000457788   ENSP00000454589   ENSP00000267978   ENSP00000456914  
     ENSP00000390738   ENSP00000456667   ENSP00000456419   ENSP00000454406   ENSP00000456257  
     ENSP00000455788   ENSP00000455803   ENSP00000457833  

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    Uscn Proteins for MAN2C1


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    Uscn ELISAs and CLIAs for MAN2C1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MAN2C1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011682 Glyco_hydro_38_C
     IPR015341 Glyco_hydro_38_cen_dom
     IPR000602 Glyco_hydro_38_N
     IPR011013 Gal_mutarotase_SF_dom
     IPR011330 Glyco_hydro/deAcase_b/a-brl

    Graphical View of Domain Structure for InterPro Entry Q9NTJ4

    ProtoNet protein and cluster: Q9NTJ4

    1 Blocks protein family: IPB000602 Glycoside hydrolase

    UniProtKB/Swiss-Prot: MA2C1_HUMAN, Q9NTJ4
    Similarity: Belongs to the glycosyl hydrolase 38 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MA2C1_HUMAN, Q9NTJ4
    Catalytic activity: Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides

         Genatlas biochemistry entry for MAN2C1:
    alpha-mannosidase,class 2C,member 1,membrane type,cytoplasmic

    Enzyme Number (IUBMB): EC 3.2.1.241 2

    miRNA
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAN2C1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004559alpha-mannosidase activity IEA--
    GO:0008270zinc ion binding IEA--
    GO:0030246carbohydrate binding IEA--


    MAN2C1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for MAN2C1:
     Increased gamma-H2AX phosphory  Lamellipodia cells 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Other glycan degradation
    Other glycan degradation1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for MAN2C1):
        Other glycan degradation


    MAN2C1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAN2C1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/30 Interacting proteins for MAN2C1 (Q9NTJ42, 3 ENSP000002679784) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRRC2AP486342, 3, ENSP000003651754MINT-62800 MINT-62626 MINT-62724 I2D: score=5 STRING: ENSP00000365175
    H3F3AP842433I2D: score=1 
    H3F3BP842433I2D: score=1 
    SMC3Q9UQE73, ENSP000003547204I2D: score=1 STRING: ENSP00000354720
    POLR1CO151603, ENSP000003614654I2D: score=4 STRING: ENSP00000361465
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006013mannose metabolic process IEA--


    MAN2C1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MAN2C1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    KifunensineInhibitor of class I alpha-mannosidases[109944-15-2]
    SwainsonineInhibitor of alpha-mannosidase II[72741-87-8]
    1-Deoxymannojirimycin hydrochloridealpha-Mannosidase I inhibitor[84444-90-6]
    Search CenterWatch for drugs/clinical trials and news about MAN2C1 / MA2C1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAN2C1 gene (4 alternative transcripts): 
    NM_001256494.1  NM_001256495.1  NM_001256496.1  NM_006715.3  

    Unigene Clusters for MAN2C1:

    Mannosidase, alpha, class 2C, member 1
    Hs.26232  [show with all ESTs], Hs.598731  [show with all ESTs]
    Unigene Representative Sequences: BX647111, BC010081
    18/42 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 42):
    ENST00000562067 ENST00000564929 ENST00000569482 ENST00000565683(uc002bah.3)
    ENST00000563622(uc010bkk.3) ENST00000267978(uc002baf.3 uc002bag.3 uc010umi.1 uc010umj.1)
    ENST00000561693 ENST00000566099 ENST00000566569 ENST00000563528 ENST00000567163
    ENST00000564570 ENST00000564785 ENST00000567360 ENST00000563441 ENST00000563368
    ENST00000569176 ENST00000566013

    miRNA
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    Inhib. RNA
    Products:
         
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAN2C1 (see all 6)
    OriGene siRNA: MAN2C1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAN2C1
    Clone
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    Additional cDNA sequence: BC010081.2 

    24/41 DOTS entries (see all 41):

    DT.100830878  DT.75103591  DT.100784834  DT.102839744  DT.100037002  DT.100772863  DT.87017892  DT.99938837 
    DT.95285978  DT.121052819  DT.75103192  DT.95134376  DT.102839743  DT.101984918  DT.87016070  DT.91758163 
    DT.100801898  DT.100801902  DT.121052738  DT.121052767  DT.40257454  DT.95294448  DT.95313666  DT.100801909 

    23 AceView cDNA sequences:

    BM542205 CD108955 BC010081 AA774591 AA236459 BF439747 AA460970 AA460369 
    CD251769 AW195462 AI564808 AW137397 CA444315 AI038103 AW204250 BF972814 
    BU660448 BX111851 AA476633 AA234078 AA461280 C75138 AA460803 

    GeneLoc Exon Structure

    5/27 Alternative Splicing Database (ASD) splice patterns (SP) for MAN2C1 (see all 27)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^
    SP1:              -                 -                       -                                               -     -                       -     -               
    SP2:              -                 -                       -                                               -     -                       -     -               
    SP3:              -                 -                                                                                                                           
    SP4:              -                 -                       -                                                                                                   
    SP5:                                                        -                                                     -                                             

    ExUns: 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b ^ 24a · 24b · 24c ^ 25a ·
    SP1:                                -           -           -                       -           -     -                                                     -   
    SP2:                                -           -           -                       -           -     -                                                     -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25b · 25c · 25d ^ 26 ^ 27a · 27b ^ 28a · 28b · 28c ^ 29
    SP1:  -           -                                             
    SP2:  -           -           -                                 
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for MAN2C1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAN2C1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGCCCACAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MAN2C1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAN2C1

    SOURCE GeneReport for Unigene clusters: Hs.26232 Hs.598731
        SABiosciences Custom PCR Arrays for MAN2C1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAN2C1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for MAN2C1 gene from 6/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Man2c11 , 5 mannosidase, alpha, class 2C, member 11, 5 87.17(n)1
    89.99(a)1
      9 (30.89 cM)5
    737441  NM_028636.21  NP_082912.11 
     571306905 
    chicken
    (Gallus gallus)
    Aves MAN2C16
    Uncharacterized protein
    70(a)
    1 ↔ 1
    10(3507351-3518987)
    lizard
    (Anolis carolinensis)
    Reptilia MAN2C16
    --
    62(a)
    1 ↔ 1
    AAWZ02040306(3769-5633)
    zebrafish
    (Danio rerio)
    Actinopterygii BM316533.12   -- 75.23(n)    BM316533.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AMS1(YGL156W)4
    AMS11
    Vacuolar alpha mannosidase, involved in free oligosaccharide more4
    Ams1p1
    45.02(n)1
    39.05(a)1
      7(210416-213667)4
    8527211, 4  NP_011359.11, 4 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria mngB6
    alpha-mannosidase
    18(a)
    1 ↔ 1
    Chromosome(767201-769834)


    ENSEMBL Gene Tree for MAN2C1 (if available)
    TreeFam Gene Tree for MAN2C1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/307 NCBI SNPs in MAN2C1 are shown (see all 307    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1838333631,2
    --75647641(+) TGTCCG/TGTCCT 8 -- us2k1 ds5001 int10--------
    rs57459321,2
    C,F--75647729(+) ACAGTT/CTGCCT 8 -- ds5001 us2k1 int13Minor allele frequency- C:0.02NS NA 172
    rs44625601,2
    C,F,A,H,--75647964(+) TGGTGC/GCTCGA 8 -- ds5001 us2k1 int128Minor allele frequency- N:0.00NS EA NA WA CSA 1831
    rs1892848761,2
    --75648098(+) CAAGCA/GTGAGG 4 -- int10--------
    rs57459331,2
    C,F,H,--75648138(+) TTCCCG/AATCCA 4 -- ut315Minor allele frequency- A:0.01NS EA 588
    rs2005479801,2
    --75648207(+) GGAGTC/TCCCAG 4 -- ut310--------
    rs11289781,2
    H--75648299(-) CTTTTC/TTCCCT 8 S F mis1 ese3 trp34Minor allele frequency- T:0.00MN NS NA 388
    rs1996371321,2
    --75648356(+) CTGGTA/CGCTCC 8 R L mis10--------
    rs1822118021,2
    C,--75648361(+) CGCTCC/TAAGAG 8 L syn10--------
    rs2012386291,2
    --75648381(+) GGAGAA/GCAGGA 4 -- int10--------

    HapMap Linkage Disequilibrium report for MAN2C1 (75648133 - 75660971 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MAN2C1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAN2C1
    DNA2.0 Custom Variant and Variant Library Synthesis for MAN2C1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MAN2C1 for disorders           About GeneDecksing

    OMIM gene information: 154580    OMIM disorders: --

    11 diseases for MAN2C1:    About MalaCards
    pneumatosis cystoides intestinalis    mannosidosis    meckel's diverticulum    mannosidase deficiency disease
    epididymitis    esophageal carcinoma    esophagitis    pneumonia
    immunodeficiency    carcinoma    prostatitis


    Export disorders for MAN2C1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAN2C1 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with MAN2C1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    3. Isolation, characterization, and expression of cDNAs encoding murine alpha-mannosidase II, a Golgi enzyme that controls conversion of high mannose to complex N-glycans. (PubMed id 1757461)1, 3 Moremen K.W. and Robbins P.W. (1991)
    4. Assignment of cytoplasmic alpha-mannosidase (MANA) and confirmation of mitochondrial isocitrate dehydrogenase (IDHM) to the q11 leads to qter region of chromosome 15 in man. (PubMed id 752528)1, 3 Champion M.J....Shows T.B. (1978)
    5. Inhibition of alpha-mannosidase Man2c1 gene expression suppresses growth of esophageal carcinoma cells through mitotic arrest and apoptosis. (PubMed id 19018777)1, 9 Tian Y....Zhu L.P. (2008)
    6. Inhibition of the alpha-mannosidase Man2c1 gene expression enhances adhesion of Jurkat cells. (PubMed id 16721356)1, 9 Qu L....Zhu L.P. (2006)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Gene expression and methylation signatures of MAN2C1 are associated with PTSD. (PubMed id 21508515)1 Uddin M....Koenen K.C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4123 HGNC: 6827 AceView: MAN2C1.1 Ensembl:ENSG00000140400 euGenes: HUgn4123
    ECgene: MAN2C1 Kegg: 4123 H-InvDB: MAN2C1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAN2C1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAN2C1 gene:
    Search GeneIP for patents involving MAN2C1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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