Aliases for MAN2C1 Gene
External Ids for MAN2C1 Gene
Previous Symbols for MAN2C1 Gene
GeneCards Summary for MAN2C1 Gene
MAN2C1 (Mannosidase, Alpha, Class 2C, Member 1) is a Protein Coding gene. Diseases associated with MAN2C1 include mannosidosis. Among its related pathways are Other glycan degradation. GO annotations related to this gene include carbohydrate binding and alpha-mannosidase activity.
Mannosidases are divided into two subtypes; I and II, (EC numbers 126.96.36.199 and 188.8.131.52 respectively) which display a wide expression pattern. Mannosidase I hydrolyzes (1,2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2 and mannosidase II hydrolyzes (1,3)- and (1,6)-linked alpha-D-mannose residues in Man5(GlcNAc)3. Both subtypes require a divalent cation cofactor. Mutations in mannosidases can cause mannosidosis (mannosidase I deficiency).