Aliases for MAN2C1 Gene
External Ids for MAN2C1 Gene
Previous HGNC Symbols for MAN2C1 Gene
Previous GeneCards Identifiers for MAN2C1 Gene
GeneCards Summary for MAN2C1 Gene
MAN2C1 (Mannosidase, Alpha, Class 2C, Member 1) is a Protein Coding gene. Diseases associated with MAN2C1 include mannosidosis. Among its related pathways are Other glycan degradation. GO annotations related to this gene include carbohydrate binding and alpha-mannosidase activity.
Mannosidases are divided into two subtypes; I and II, (EC numbers 188.8.131.52 and 184.108.40.206 respectively) which display a wide expression pattern. Mannosidase I hydrolyzes (1,2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2 and mannosidase II hydrolyzes (1,3)- and (1,6)-linked alpha-D-mannose residues in Man5(GlcNAc)3. Both subtypes require a divalent cation cofactor. Mutations in mannosidases can cause mannosidosis (mannosidase I deficiency).