Aliases for MAN2B2 Gene
External Ids for MAN2B2 Gene
Previous GeneCards Identifiers for MAN2B2 Gene
GeneCards Summary for MAN2B2 Gene
MAN2B2 (Mannosidase, Alpha, Class 2B, Member 2) is a Protein Coding gene. Diseases associated with MAN2B2 include mannosidosis. Among its related pathways are Other glycan degradation. GO annotations related to this gene include carbohydrate binding and alpha-mannosidase activity. An important paralog of this gene is MAN2B1.
Mannosidases are divided into two subtypes; I and II, (EC numbers 184.108.40.206 and 220.127.116.11 respectively) which display a wide expression pattern. Mannosidase I hydrolyzes (1,2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2 and mannosidase II hydrolyzes (1,3)- and (1,6)-linked alpha-D-mannose residues in Man5(GlcNAc)3. Both subtypes require a divalent cation cofactor. Mutations in mannosidases can cause mannosidosis (mannosidase I deficiency).