Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MAN2B2 Gene

protein-coding   GIFtS: 58
GCID: GC04P006509

Mannosidase, Alpha, Class 2B, Member 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Mannosidase, Alpha, Class 2B, Member 21 2     Core-Specific Lysosomal Alpha-1,6-Mannosidase2
EC 3.2.1.243 8     Epididymis-Specific Alpha-Mannosidase2
6-Mannosidase1     KIAA09353
Core-Specific Lysosomal Alpha-11     Mannosidase Alpha Class 2B Member 23

External Ids:    HGNC: 296231   Entrez Gene: 233242   Ensembl: ENSG000000132887   UniProtKB: Q9Y2E53   

Export aliases for MAN2B2 gene to outside databases

Previous GC identifers: GC04P006642 GC04P006694 GC04P006627


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for MAN2B2 Gene:
MAN2B2 (mannosidase, alpha, class 2B, member 2) is a protein-coding gene. Diseases associated with MAN2B2 include hiv-1, and breast cancer. GO annotations related to this gene include carbohydrate binding and alpha-mannosidase activity. An important paralog of this gene is MAN2B1.

summary for MAN2B2 Gene:
Mannosidases are divided into two subtypes; I and II, (EC numbers 3.2.1.113 and 3.2.1.114 respectively)
which display a wide expression pattern. Mannosidase I hydrolyzes (1,2)-linked alpha-D-mannose residues in
the oligo-mannose oligosaccharide Man9(GlcNAc)2 and mannosidase II hydrolyzes (1,3)- and (1,6)-linked
alpha-D-mannose residues in Man5(GlcNAc)3. Both subtypes require a divalent cation cofactor. Mutations in
mannosidases can cause mannosidosis (mannosidase I deficiency).

Gene Wiki entry for MAN2B2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000004.12  NT_006051.19  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAN2B2 gene promoter:
         Elk-1   AML1a   NCX/Ncx   HTF   Bach2   AP-4   E47   Hand1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAN2B2 promoter sequence
   Search Chromatin IP Primers for MAN2B2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAN2B2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.2

MAN2B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAN2B2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P006509:  view genomic region     (about GC identifiers)

Start:
6,576,902 bp from pter      End:
6,625,089 bp from pter
Size:
48,188 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MA2B2_HUMAN, Q9Y2E5 (See protein sequence)
Recommended Name: Epididymis-specific alpha-mannosidase precursor  
Size: 1009 amino acids; 113979 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Secondary accessions: Q66MP2 Q86T67
Alternative splicing: 2 isoforms:  Q9Y2E5-1   Q9Y2E5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAN2B2: NX_Q9Y2E5

Explore proteomics data for MAN2B2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn226, Asn249, Asn294, Asn336, Asn516, Asn608, Asn670, Asn675, Asn748, Asn808,
                                 Asn812, Asn890
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAN2B2 (Q9Y2E5) (see all 8)
     IRQYFYR  HVLWPWGCD  PKEIRTFFI  RRFIAVEQE 


    See MAN2B2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056089.1  
    ENSEMBL proteins: 
     ENSP00000285599   ENSP00000423129   ENSP00000426273  

    MAN2B2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MAN2B2
    OriGene Protein Over-expression Lysate for MAN2B2
    OriGene MassSpec for MAN2B2
    OriGene Custom Protein Services for MAN2B2
    GenScript Custom Purified and Recombinant Proteins Services for MAN2B2
    Novus Biologicals MAN2B2 Protein
    Novus Biologicals MAN2B2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAN2B2

    MAN2B2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MAN2B2
    Novus Biologicals MAN2B2 Antibodies
    Abcam antibodies for MAN2B2
    Cloud-Clone Corp. Antibodies for MAN2B2
    ThermoFisher Antibodies for MAN2B2
    LSBio Antibodies in human, mouse, rat for MAN2B2

    MAN2B2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAN2B2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAN2B2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAN2B2
    Cloud-Clone Corp. CLIAs for MAN2B2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 7):
     IPR027291 Glyco_hydro_38/57_N
     IPR011682 Glyco_hydro_38_C
     IPR015341 Glyco_hydro_38_cen
     IPR000602 Glyco_hydro_38_N
     IPR011013 Gal_mutarotase_SF_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y2E5

    ProtoNet protein and cluster: Q9Y2E5

    1 Blocks protein domain: IPB000602 Glycoside hydrolase

    UniProtKB/Swiss-Prot: MA2B2_HUMAN, Q9Y2E5
    Similarity: Belongs to the glycosyl hydrolase 38 family


    MAN2B2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MA2B2_HUMAN, Q9Y2E5
    Catalytic activity: Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides

         Enzyme Number (IUBMB): EC 3.2.1.241 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004553hydrolase activity, hydrolyzing O-glycosyl compounds ----
    GO:0004559alpha-mannosidase activity IEA--
    GO:0008270zinc ion binding IEA--
    GO:0015923mannosidase activity ----
         
    MAN2B2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Man2b2 (no phenotypes)

    MAN2B2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAN2B2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAN2B2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAN2B2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAN2B2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MAN2B2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MAN2B2
    SwitchGear 3'UTR luciferase reporter plasmidMAN2B2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAN2B2
    Predesigned siRNA for gene silencing in human, mouse, rat MAN2B2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAN2B2

    Clone
    Products:
         
    OriGene clones in human, mouse for MAN2B2 (see all 7)
    OriGene ORF clones in mouse, rat for MAN2B2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAN2B2 (NM_015274)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAN2B2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAN2B2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MAN2B2
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAN2B2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAN2B2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MA2B2_HUMAN, Q9Y2E5: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    lysosome2
    vacuole2
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005764lysosome IEA--

    MAN2B2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MAN2B2 About    
    See pathways by source

    SuperPathContained pathways About
    1Other glycan degradation
    Other glycan degradation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for MAN2B2):
        Other glycan degradation


    MAN2B2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAN2B2
    Interactions:

        Search GeneGlobe Interaction Network for MAN2B2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for MAN2B2 (ENSP000002855994) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NRF1ENSP000002231904STRING: ENSP00000223190
    UBCENSP000003448184STRING: ENSP00000344818
    GLAENSP000002185164STRING: ENSP00000218516
    NAGAENSP000003796804STRING: ENSP00000379680
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006013mannose metabolic process IEA--

    MAN2B2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MAN2B2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    KifunensineInhibitor of class I alpha-mannosidases[109944-15-2]
    1-DeoxynojirimycinGlucosidase I and II inhibitor[19130-96-2]
    1-Deoxymannojirimycin hydrochloridealpha-Mannosidase I inhibitor[73465-43-7]
    Miglitolalpha-glucosidase inhibitor[72432-03-2]
    OGT 2115Antiangiogenic. Heparanase inhibitor[853929-59-6]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MAN2B2 gene: 
    NM_015274.1  

    Unigene Cluster for MAN2B2:

    Mannosidase, alpha, class 2B, member 2
    Hs.188464  [show with all ESTs]
    Unigene Representative Sequence: AB023152
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000285599(uc003gjf.1 uc011bwf.1) ENST00000504248 ENST00000505907(uc003gje.1)
    ENST00000504960 ENST00000510427
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MAN2B2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MAN2B2
    SwitchGear 3'UTR luciferase reporter plasmidMAN2B2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MAN2B2
    Predesigned siRNA for gene silencing in human, mouse, rat MAN2B2
    Clone
    Products:
         
    OriGene clones in human, mouse for MAN2B2 (see all 7)
    OriGene ORF clones in mouse, rat for MAN2B2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAN2B2 (NM_015274)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAN2B2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAN2B2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MAN2B2
    OriGene qSTAR qPCR primer pairs in human, mouse for MAN2B2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAN2B2
      QuantiTect SYBR Green Assays in human, mouse, rat MAN2B2
      QuantiFast Probe-based Assays in human, mouse, rat MAN2B2

    Additional mRNA sequence: 

    AB023152.2 AK025803.1 AK075246.1 AK301473.1 AL832232.1 AL833071.2 BC033307.1 BC036836.1 
    BC094773.1 

    6 DOTS entries:

    DT.86821188  DT.91746681  DT.75104999  DT.91746888  DT.91746885  DT.95186161 

    Selected AceView cDNA sequences (see all 158):

    CA307809 BU680307 BM992724 BU619116 AW028664 AW954107 AA150972 NM_015274 
    AA936695 AI288724 CA950567 BU622087 AA770632 AA761757 BE350323 AA915892 
    AI087212 BP873292 AW845199 BM508070 CA950331 BM998728 BQ007851 AA368940 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MAN2B2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20
    SP1:                                                                                -                                               -               
    SP2:                                                                                                                                                
    SP3:                                                                                                                                                


    ECgene alternative splicing isoforms for MAN2B2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MAN2B2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGCTAACA
    MAN2B2 Expression
    About this image


    MAN2B2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Spinal Cord (Nervous System)
    MAN2B2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAN2B2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.188464
        Custom PCR Arrays for MAN2B2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for MAN2B2
    OriGene qSTAR qPCR primer pairs in human, mouse for MAN2B2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAN2B2
    QuantiTect SYBR Green Assays in human, mouse, rat MAN2B2
    QuantiFast Probe-based Assays in human, mouse, rat MAN2B2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAN2B2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MAN2B2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Man2b21 , 5 mannosidase 2, alpha B21, 5 79.03(n)1
    76.14(a)1
      5 (19.26 cM)5
    171601  NM_008550.21  NP_032576.21 
     368069215 
    chicken
    (Gallus gallus)
    Aves MAN2B21 mannosidase, alpha, class 2B, member 2 65.82(n)
    67.45(a)
      422859  XM_420805.4  XP_420805.2 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia man2b21 mannosidase, alpha, class 2B, member 2 62.11(n)
    62.65(a)
      100127706  NM_001113044.1  NP_001106515.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.23572 Transcribed sequence with moderate similarity to protein more 74.23(n)    CK138883.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta alpha-Man-IIb6
    alpha-Man-IIb
    18(a)
    many ↔ many
    3R(11629974-11649840)


    ENSEMBL Gene Tree for MAN2B2 (if available)
    TreeFam Gene Tree for MAN2B2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MAN2B2 gene
    MAN2B12  MAN2A22  ENSG000002692422  ENSG000002695902  MAN2A12  
    1 SIMAP similar gene for MAN2B2 using alignment to 5 protein entries:     MA2B2_HUMAN (see all proteins):
    MAN2A2

    MAN2B2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MAN2B2 (see all 1412)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1903623511,2
    --6574944(+) TTCTGG/TCCCCA 1 -- us2k10--------
    rs1161949901,2
    F--6575055(+) AAACGT/GTCTGA 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1817206171,2
    --6575061(+) TCTGAC/GATATT 1 -- us2k10--------
    rs1173201851,2
    C,F--6575091(+) GTCAAC/TCAAAT 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1858509201,2
    --6575116(+) GGGGGG/TTGGGT 1 -- us2k10--------
    rs1404998191,2
    C--6575150(+) CAGATA/TCAGTC 1 -- us2k10--------
    rs1893067941,2
    --6575263(+) CATGTG/TGTTCT 1 -- us2k10--------
    rs100310301,2
    C,F--6575282(+) TCCATT/CGGTGG 1 -- us2k19Minor allele frequency- C:0.41NA WA CSA EA 370
    rs1808963791,2
    C--6575406(+) GCCCGC/TCCCCA 1 -- us2k10--------
    rs1444535151,2
    C--6575495(+) TGGCCA/GGTCAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MAN2B2 (6576902 - 6625089 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAN2B2 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2727004CNV Deletion23290073
    esv2657120CNV Deletion23128226
    nsv461189CNV Loss19166990
    nsv10440CNV Loss18304495
    nsv4215CNV Loss18451855
    nsv878526CNV Loss21882294
    nsv829849CNV Loss17160897
    nsv10441CNV Loss18304495
    nsv470006CNV Loss18288195
    nsv526206CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAN2B2
    DNA2.0 Custom Variant and Variant Library Synthesis for MAN2B2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    2 diseases for MAN2B2:    
    About MalaCards
    hiv-1    breast cancer


    MAN2B2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MAN2B2
    Human Genome Epidemiology (HuGE) Navigator: MAN2B2 (2 documents)

    Export disorders for MAN2B2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MAN2B2 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with MAN2B2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    5. Characterization of a human core-specific lysosomal {alpha}1,6-mannosidase involved in N-glycan catabolism. (PubMed id 16115860)1, 3 Park C....Moremen K.W. (J. Biol. Chem. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Human lysosomal alpha-mannosidases exhibit different inhibition and metal binding properties. (PubMed id 19722277)1, 9 Venkatesan M....Rose D.R. (Protein Sci. 2009)
    8. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (J. Proteome Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 23324 HGNC: 29623 AceView: MAN2B2 Ensembl:ENSG00000013288 euGenes: HUgn23324
    ECgene: MAN2B2 Kegg: 23324 H-InvDB: MAN2B2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0935

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MAN2B2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MAN2B2 gene:
    Search GeneIP for patents involving MAN2B2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MAN2B2  
     OriGene qPCR primer pairs and template standards for MAN2B2   OriGene Protein Over-expression Lysate for MAN2B2  
     OriGene MassSpec something-or-other for MAN2B2   OriGene clones in human, mouse for MAN2B2  
     OriGene qSTAR qPCR primer pairs in human, mouse for MAN2B2   OriGene Purified Protein for MAN2B2  
     OriGene ORF clones in mouse, rat for MAN2B2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MAN2B2   OriGene Custom Protein Services for MAN2B2  

     
     
     Block miRNA regulation of human, mouse, rat MAN2B2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MAN2B2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAN2B2 Predesigned siRNA for gene silencing in human, mouse, rat MAN2B2
     QuantiFast Probe-based Assays in human, mouse, rat MAN2B2 QuantiTect SYBR Green Assays in human, mouse, rat MAN2B2
     Custom PCR Arrays for MAN2B2 Search Chromatin IP Primers for MAN2B2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAN2B2  Search GeneGlobe Interaction Network for MAN2B2
     Regulatory tfbs in MAN2B2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MAN2B2 GenScript cDNA clones with any tag delivered in your preferred vector for MAN2B2
     GenScript Custom Assay Services for MAN2B2 GenScript Custom overexpressing Cell Line Services for MAN2B2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for MAN2B2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MAN2B2 antibodies
     MAN2B2 proteins
     MAN2B2 lysates
     Antibodies for MAN2B2
     See all of Abcam's Antibodies, Kits and Proteins for MAN2B2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MAN2B2
     Antibodies for MAN2B2
     ELISAs for MAN2B2
     CLIAs for MAN2B2



     Browse ESI BIO Cell Lines and PureStem Progenitors for MAN2B2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAN2B2
     SwitchGear 3'UTR luciferase reporter plasmids for MAN2B2
     SwitchGear Promoter luciferase reporter plasmids for MAN2B2
     ThermoFisher Antibodies for MAN2B2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAN2B2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAN2B2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAN2B2
     LSBio Antibodies in human, mouse, rat for MAN2B2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MAN2B2 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4