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Aliases for MAN2B2 Gene

Aliases for MAN2B2 Gene

  • Mannosidase Alpha Class 2B Member 2 2 3 4
  • Mannosidase, Alpha, Class 2B, Member 2 2 5
  • EC 4 63
  • Core-Specific Lysosomal Alpha-1,6-Mannosidase 2
  • KIAA0935 4

External Ids for MAN2B2 Gene

Previous GeneCards Identifiers for MAN2B2 Gene

  • GC04P006642
  • GC04P006694
  • GC04P006627
  • GC04P006509

Summaries for MAN2B2 Gene

GeneCards Summary for MAN2B2 Gene

MAN2B2 (Mannosidase Alpha Class 2B Member 2) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. GO annotations related to this gene include carbohydrate binding and alpha-mannosidase activity. An important paralog of this gene is MAN2B1.

Tocris Summary for MAN2B2 Gene

  • Glycosylases are a group of enzymes that includes glucosidases, mannosidases and heparanases. There are two glucosidase subtypes, both found in the gut. They hydrolyze terminal (1,4)alpha-glucosidic linkages and (1,6)beta-glucosidic linkages, liberating alpha-glucose and beta-glucose.

Gene Wiki entry for MAN2B2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAN2B2 Gene

Genomics for MAN2B2 Gene

Regulatory Elements for MAN2B2 Gene

Enhancers for MAN2B2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAN2B2 on UCSC Golden Path with GeneCards custom track

Promoters for MAN2B2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAN2B2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAN2B2 Gene

6,575,174 bp from pter
6,623,362 bp from pter
48,189 bases
Plus strand

Genomic View for MAN2B2 Gene

Genes around MAN2B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAN2B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAN2B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAN2B2 Gene

Proteins for MAN2B2 Gene

  • Protein details for MAN2B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Epididymis-specific alpha-mannosidase
    Protein Accession:
    Secondary Accessions:
    • Q66MP2
    • Q86T67

    Protein attributes for MAN2B2 Gene

    1009 amino acids
    Molecular mass:
    113979 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MAN2B2 Gene


neXtProt entry for MAN2B2 Gene

Proteomics data for MAN2B2 Gene at MOPED

Post-translational modifications for MAN2B2 Gene

  • Glycosylation at Asn 226, Asn 249, Asn 294, Asn 336, Asn 516, Asn 608, Asn 670, Asn 675, Asn 748, Asn 808, Asn 812, and Asn 890
  • Modification sites at PhosphoSitePlus

Other Protein References for MAN2B2 Gene

Domains & Families for MAN2B2 Gene

Gene Families for MAN2B2 Gene

Suggested Antigen Peptide Sequences for MAN2B2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 38 family.
  • Belongs to the glycosyl hydrolase 38 family.
genes like me logo Genes that share domains with MAN2B2: view

Function for MAN2B2 Gene

Molecular function for MAN2B2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Enzyme Numbers (IUBMB) for MAN2B2 Gene

Gene Ontology (GO) - Molecular Function for MAN2B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004559 alpha-mannosidase activity IEA,IBA --
GO:0008496 mannan endo-1,6-alpha-mannosidase activity TAS --
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with MAN2B2: view
genes like me logo Genes that share phenotypes with MAN2B2: view

Animal Models for MAN2B2 Gene

MGI Knock Outs for MAN2B2:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAN2B2 Gene

Localization for MAN2B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAN2B2 Gene


Subcellular locations from

Jensen Localization Image for MAN2B2 Gene COMPARTMENTS Subcellular localization image for MAN2B2 gene
Compartment Confidence
extracellular 5
lysosome 2
vacuole 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for MAN2B2 Gene

Pathways & Interactions for MAN2B2 Gene

genes like me logo Genes that share pathways with MAN2B2: view

Pathways by source for MAN2B2 Gene

1 KEGG pathway for MAN2B2 Gene

Interacting Proteins for MAN2B2 Gene

Gene Ontology (GO) - Biological Process for MAN2B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0009313 oligosaccharide catabolic process TAS --
genes like me logo Genes that share ontologies with MAN2B2: view

No data available for SIGNOR curated interactions for MAN2B2 Gene

Drugs & Compounds for MAN2B2 Gene

(2) Drugs for MAN2B2 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acarbose Approved, Investigational Pharma Alpha-glucosidase inhibitor, Glucosidase alpha inhibitor (intestinal) 81
1-Deoxynojirimycin Experimental Pharma Glucosidase I and II inhibitor 0

(5) Additional Compounds for MAN2B2 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
  • Dihydrogen oxide
  • Steam
1-Deoxymannojirimycin hydrochloride
OGT 2115

(5) Tocris Compounds for MAN2B2 Gene

Compound Action Cas Number
1-Deoxymannojirimycin hydrochloride alpha-Mannosidase I inhibitor 73465-43-7
1-Deoxynojirimycin Glucosidase I and II inhibitor 19130-96-2
Acarbose Glucosidase alpha inhibitor (intestinal) 56180-94-0
Castanospermine Glucosidases alpha and beta inhibitor 79831-76-8
OGT 2115 Antiangiogenic. Heparanase inhibitor 853929-59-6
genes like me logo Genes that share compounds with MAN2B2: view

Transcripts for MAN2B2 Gene

Unigene Clusters for MAN2B2 Gene

Mannosidase, alpha, class 2B, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAN2B2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20
SP1: - -

Relevant External Links for MAN2B2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAN2B2 Gene

mRNA expression in normal human tissues for MAN2B2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAN2B2 Gene

This gene is overexpressed in Bone marrow stromal cell (10.8), Skin (10.7), Pancreas (9.9), and Peripheral blood mononuclear cells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAN2B2 Gene

SOURCE GeneReport for Unigene cluster for MAN2B2 Gene Hs.188464

genes like me logo Genes that share expression patterns with MAN2B2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MAN2B2 Gene

Orthologs for MAN2B2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAN2B2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC532207 35
  • 75.47 (n)
  • 67.83 (a)
-- 36
  • 58 (a)
-- 36
  • 66 (a)
-- 36
  • 66 (a)
-- 36
  • 49 (a)
(Canis familiaris)
Mammalia MAN2B2 35
  • 79.05 (n)
  • 71.87 (a)
-- 36
  • 68 (a)
-- 36
  • 68 (a)
(Mus musculus)
Mammalia Man2b2 35
  • 79.03 (n)
  • 76.14 (a)
Man2b2 16
Man2b2 36
  • 75 (a)
(Pan troglodytes)
Mammalia MAN2B2 35
  • 92.5 (n)
  • 90.46 (a)
(Rattus norvegicus)
Mammalia Man2b2 35
  • 79.76 (n)
  • 75.47 (a)
(Monodelphis domestica)
Mammalia MAN2B2 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia MAN2B2 36
  • 55 (a)
(Gallus gallus)
Aves MAN2B2 35
  • 65.82 (n)
  • 67.45 (a)
MAN2B2 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia man2b2 35
  • 62.11 (n)
  • 62.65 (a)
(Danio rerio)
Actinopterygii Dr.2357 35
man2b2 35
  • 61.24 (n)
  • 60.04 (a)
MAN2B2 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta alpha-Man-IIb 36
  • 18 (a)
Species with no ortholog for MAN2B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAN2B2 Gene

Gene Tree for MAN2B2 (if available)
Gene Tree for MAN2B2 (if available)

Paralogs for MAN2B2 Gene

Paralogs for MAN2B2 Gene

(1) SIMAP similar genes for MAN2B2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MAN2B2: view

Variants for MAN2B2 Gene

Sequence variations from dbSNP and Humsavar for MAN2B2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs2301796 - 6,593,220(-) CATCT(C/G/T)GGGGA nc-transcript-variant, reference, missense
rs2301795 - 6,594,633(-) CTGCA(C/G/T)CGAGA nc-transcript-variant, reference, missense
rs2301790 - 6,598,285(-) GCGCA(A/C/G/T)GCCCA nc-transcript-variant, reference, missense
rs2301788 - 6,605,137(-) TGATG(C/T)TGTAG nc-transcript-variant, reference, missense
rs6858328 - 6,597,148(+) CGTCC(A/C/G/T)GCAGC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MAN2B2 Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
nsv829849 CNV Loss 17160897
nsv878526 CNV Loss 21882294
nsv461189 CNV Loss 19166990
nsv470006 CNV Loss 18288195
nsv878527 CNV Gain 21882294
esv2727004 CNV Deletion 23290073
nsv526206 CNV Gain 19592680
dgv1567e1 CNV Complex 17122850
nsv4215 CNV Loss 18451855
nsv10440 CNV Loss 18304495
esv2657120 CNV Deletion 23128226
essv23633 CNV CNV 17122850
nsv10441 CNV Loss 18304495

Variation tolerance for MAN2B2 Gene

Residual Variation Intolerance Score: 99.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.02; 95.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MAN2B2 Gene

Disorders for MAN2B2 Gene

Relevant External Links for MAN2B2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MAN2B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAN2B2 Gene

Publications for MAN2B2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. Human lysosomal alpha-mannosidases exhibit different inhibition and metal binding properties. (PMID: 19722277) Venkatesan M. … Rose D.R. (Protein Sci. 2009) 3 23
  3. Characterization of a human core-specific lysosomal {alpha}1,6-mannosidase involved in N-glycan catabolism. (PMID: 16115860) Park C. … Moremen K.W. (J. Biol. Chem. 2005) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for MAN2B2 Gene

Sources for MAN2B2 Gene