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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MAN2A2 Gene

protein-coding GIFtS: 59
GCID: GC15P091447

mannosidase, alpha, class 2A, member 2

Explore 4 diseases affiliated with
MAN2A2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Mannosidase, Alpha, Class 2A, Member 2¹ ²		HsT19662¹
MANA2X¹ ² ³ ⁵		Alpha-Mannosidase 2x²
Alpha-Mannosidase IIx² ³		Mannosidase, Alpha Type II-X²
Man IIx² ³		Manosidase, Alpha-, Type II, Isozyme X²
Mannosyl-Oligosaccharide 1,3-1,6-Alpha-Mannosidase² ³		Mannosidase Alpha Class 2A Member 2³
EC 3.2.1.114³ ⁸

External Ids:	HGNC: 6825¹	Entrez Gene: 4122²	Ensembl: ENSG00000196547⁷	OMIM: 600988⁵	UniProtKB: P49641³

Export aliases for MAN2A2 gene to outside databases

Previous GC identifers: GC15P087634 GC15P084886 GC15P089033 GC15P089175 GC15P089247 GC15P067558

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MA2A2_HUMAN, P49641

Function: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high

mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway

summary for MAN2A2:

Mannosidases are divided into two subtypes; I and II, (EC numbers 3.2.1.113 and 3.2.1.114 respectively)

which display a wide expression pattern. Mannosidase I hydrolyzes (1,2)-linked alpha-D-mannose residues in

the oligo-mannose oligosaccharide Man9(GlcNAc)2 and mannosidase II hydrolyzes (1,3)- and (1,6)-linked

alpha-D-mannose residues in Man5(GlcNAc)3. Both subtypes require a divalent cation cofactor. Mutations in

mannosidases can cause mannosidosis (mannosidase I deficiency).

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010274.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MAN2A2 gene promoter:
NF-1/L NF-1 Nkx2-5 E47 c-Ets-1 CREB Ik-2 STAT3 Hand1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAN2A2 promoter sequence

Search SABiosciences Chromatin IP Primers for MAN2A2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAN2A2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1 Ensembl cytogenetic band: 15q26.1 HGNC cytogenetic band: 15q25

MAN2A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAN2A2 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P091447: view genomic region (about GC identifiers)

Start:	91,445,448 bp from pter	End:	91,465,815 bp from pter
Size:	20,368 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MA2A2_HUMAN, P49641 (See protein sequence)

Recommended Name: Alpha-mannosidase 2x

Size: 1150 amino acids; 130539 Da

Cofactor: Binds 1 zinc ion per subunit (By similarity)

Subunit: Homodimer; disulfide-linked (By similarity)

Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)

Secondary accessions: A6NH12 A8K1E8 Q13754

Alternative splicing: 3 isoforms: P49641-3 P49641-1 P49641-2 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for MAN2A2: NX_P49641

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P49641

4/7 DME Specific Peptides for MAN2A2 (P49641) (see all 7)

TSRPFYK

KLPLQAN

CCQFDFKR

SGAYLFLP

MAN2A2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006113.2

ENSEMBL proteins:

ENSP00000453740 ENSP00000452691 ENSP00000453078 ENSP00000453999 ENSP00000452631

ENSP00000452948 ENSP00000453956 ENSP00000452897 ENSP00000453140 ENSP00000452866

ENSP00000452928 ENSP00000452813 ENSP00000453253 ENSP00000453341 ENSP00000453659

ENSP00000353655 ENSP00000388221 ENSP00000394372

Reactome Protein details: P49641
Human Recombinant Protein Products for MAN2A2:

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	Browse Sino Biological Recombinant Proteins
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	Uscn Proteins for MAN2A2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

MAN2A2 for ontologies About GeneDecksing

MAN2A2 Antibody Products:

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	Uscn ELISAs and CLIAs for MAN2A2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MAN2A2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR011682 Glyco_hydro_38_C

IPR015341 Glyco_hydro_38_cen_dom

IPR000602 Glyco_hydro_38_N

IPR011013 Gal_mutarotase_SF_dom

IPR011330 Glyco_hydro/deAcase_b/a-brl

Graphical View of Domain Structure for InterPro Entry P49641

ProtoNet protein and cluster: P49641

1 Blocks protein family: IPB000602 Glycoside hydrolase

UniProtKB/Swiss-Prot: MA2A2_HUMAN, P49641

Similarity: Belongs to the glycosyl hydrolase 38 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MA2A2_HUMAN, P49641

Function: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high

mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway

Catalytic activity: Hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the

mannosyl-oligosaccharide Man(5)(GlcNAc)(3)

Genatlas biochemistry entry for MAN2A2:

alpha-mannosidase,class 2A,member 2,membrane type,Golgi,housekeeping gene involved in processing of Asp-linked (N)

glycans

Enzyme Number (IUBMB): EC 3.2.1.114¹ ²

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004559	alpha-mannosidase activity	--	--
GO:0004572	mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	NAS	--
GO:0008270	zinc ion binding	IEA	--
GO:0015923	mannosidase activity	--	--
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	IEA	--

MAN2A2 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for MAN2A2:

G0/1 arrest

Increased G1 DNA content

6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Man2a2):

endocrine/exocrine gland	liver/biliary system	mortality/aging	renal/urinary system	reproductive system
respiratory system

MAN2A2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Man2a2^tm1Mfu for MAN2A2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MAN2A2

miRNA Products:		OriGene 3'-UTR Clone: MAN2A2 Browse MicroRNA Expression Plasmids
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		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate MAN2A2 (see all 19):
		hsa-miR-345 hsa-miR-148b* hsa-miR-3616-5p hsa-miR-128 hsa-miR-501-5p hsa-miR-3182 hsa-miR-27a hsa-miR-324-3p

		SwitchGear 3'UTR luciferase reporter plasmid: MAN2A2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAN2A2 (see all 7) OriGene shRNA RFP: MAN2A2 OriGene siRNA: MAN2A2
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAN2A2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAN2A2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MAN2A2 (NM_006122)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAN2A2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Asparagine N-linked glycosylation

	Asparagine N-linked glycosylation	1.00			Post-translational protein modification	0.44
	N-Glycan biosynthesis	0.52			Metabolism of proteins	0.15

N-glycan antennae elongation in the medial/trans-Golgi

N-glycan antennae elongation in the medial/trans-Golgi

1.00

Transport to the Golgi and subsequent modification

0.56

Reactions specific to the complex N-glycan synthesis pathway

Reactions specific to the complex N-glycan synthesis pathway

1.00

Metabolism

Metabolic pathways

0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 Reactome Pathways for MAN2A2 (see all 6)

	N-glycan antennae elongation in the medial/trans-Golgi
	Transport to the Golgi and subsequent modification
	Reactions specific to the complex N-glycan synthesis pathway
	Asparagine N-linked glycosylation
	Metabolism of proteins

2 Kegg Pathways (Kegg details for MAN2A2):

	N-Glycan biosynthesis
	Metabolic pathways

UniProtKB/Swiss-Prot: MA2A2_HUMAN, P49641

Pathway: Protein modification; protein glycosylation

MAN2A2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MAN2A2

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

5/10 Interacting proteins for MAN2A2 (P49641^{2, 3} ENSP00000353655⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
C7orf55-LUC7L2	Q9Y383²^,³	MINT-63782 I2D: score=5
LUC7L2	Q9Y383²^,³	MINT-63782 I2D: score=5
CHD3	Q12873²^,³	MINT-63783 I2D: score=5
GIT1	Q9Y2X7²^,³	MINT-63781 I2D: score=5
VIM	P08670²^,³	MINT-63780 I2D: score=5

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	NAS	--
GO:0006013	mannose metabolic process	IEA	--
GO:0018279	protein N-linked glycosylation via asparagine	TAS	--
GO:0043687	post-translational protein modification	TAS	--
GO:0044267	cellular protein metabolic process	TAS	--

MAN2A2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for MAN2A2 available from Tocris Bioscience About this table

Compound	Action	CAS #
Kifunensine	Inhibitor of class I alpha-mannosidases	[109944-15-2]
Swainsonine	Inhibitor of alpha-mannosidase II	[72741-87-8]
1-Deoxymannojirimycin hydrochloride	alpha-Mannosidase I inhibitor	[84444-90-6]

Search CenterWatch for drugs/clinical trials and news about MAN2A2 / MA2A2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MAN2A2 gene:

NM_006122.2

Unigene Cluster for MAN2A2:

Mannosidase, alpha, class 2A, member 2

Hs.116459 [show with all ESTs]

Unigene Representative Sequence: NM_006122

18/32 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32):

ENST00000558290 ENST00000558853 ENST00000559999 ENST00000560534 ENST00000560451

ENST00000558161 ENST00000559717(uc010bnz.2 uc010uqn.1) ENST00000559965

ENST00000560192(uc010boa.3) ENST00000559132 ENST00000558640 ENST00000561046

ENST00000557865 ENST00000560616 ENST00000558171 ENST00000561240 ENST00000560505

ENST00000559374

miRNA Products:		OriGene 3'-UTR Clone: MAN2A2 Browse OriGene MicroRNA Expression Plasmids
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		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate MAN2A2 (see all 19):
		hsa-miR-345 hsa-miR-148b* hsa-miR-3616-5p hsa-miR-128 hsa-miR-501-5p hsa-miR-3182 hsa-miR-27a hsa-miR-324-3p

		SwitchGear 3'UTR luciferase reporter plasmid: MAN2A2 3' UTR sequence

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		Sirion Biotech Custom design and validation of potent shRNA sequences against MAN2A2

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		GenScript: all cDNA clones in your preferred vector: MAN2A2 (NM_006122)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAN2A2

Additional cDNA sequence:

AF116691.1 AK289863.1 AK293799.1 AK295646.1 AK299213.1 AK308838.1 AK316150.1 AL110288.1

AL832306.1 BC136448.1 BC144111.1 D55649.1 L28821.1

19 DOTS entries:

DT.100779139 DT.218593 DT.121075755 DT.121075752 DT.121075746 DT.95213617 DT.97857466 DT.91759945

DT.100659118 DT.92051263 DT.95276395 DT.121075712 DT.121075743 DT.100864734 DT.210478 DT.40115743

DT.91798153 DT.91908857 DT.92459568

24/253 AceView cDNA sequences (see all 253):

AA662481 BU149770 AA383137 BX110391 BQ424705 BM712138 CD364844 AI203660

BE819791 AI990667 BM704460 AW504300 AA984120 BE378155 BQ267491 BG403870

BQ876822 AI435782 AA631142 D55649 AI074362 AI912006 CD622022 CK819674

GeneLoc Exon Structure

5/26 Alternative Splicing Database (ASD) splice patterns (SP) for MAN2A2 (see all 26) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	·	7e	^	8a	·	8b	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14a	·
SP1:									-		-		-		-		-		-
SP2:									-		-		-		-		-		-
SP3:
SP4:
SP5:

ExUns:	14b	·	14c	^	15	^	16	^	17	^	18a	·	18b	^	19a	·	19b	·	19c	^	20a	·	20b	·	20c	^	21a	·	21b	·	21c	·	21d	·	21e	^	22	^	23a	·	23b	^	24	^	25	^	26	^	27a	·	27b	^
SP1:													-		-						-				-																-						-		-		-
SP2:													-		-						-				-		-														-						-		-		-
SP3:																																															-		-		-
SP4:																																							-		-						-		-		-
SP5:													-

ExUns:	28a	·	28b	·	28c	^	29a	·	29b	^	30	^	31a	·	31b	^	32a	·	32b	·	32c	^	33a	·	33b	·	33c	·	33d	·	33e	·	33f	·	33g
SP1:	-						-		-		-						-
SP2:	-						-		-		-						-
SP3:	-						-		-		-						-
SP4:	-						-		-		-						-
SP5:

ECgene alternative splicing isoforms for MAN2A2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MAN2A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See MAN2A2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAN2A2

SOURCE GeneReport for Unigene cluster: Hs.116459
SABiosciences Expression via Pathway-Focused PCR Array including MAN2A2:

Glycosylation in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAN2A2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAN2A2 gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MAN2A2¹	mannosidase, alpha, class 2A, member 2	77.74(n) 78.99(a)		415585 XM_001233607.2 XP_001233608.2
lizard (Anolis carolinensis)	Reptilia	MAN2A2⁶	--	75(a)	1 ↔ 1	GL343759.1(77741-97693)
zebrafish (Danio rerio)	Actinopterygii	man2a2¹	mannosidase, alpha, class 2A, member 2	67.8(n) 68.82(a)		100333987 XM_002666791.2 XP_002666837.1
fruit fly (Drosophila melanogaster)	Insecta	alpha-Man-IIb³ alpha-Man-II¹	alpha-mannosidase³ alpha Mannosidase II¹	40(a)³ 52.19(n)¹ 44.36(a)¹		89A5³ 41126¹ NM_079567.2¹ NP_524291.2¹
worm (Caenorhabditis elegans)	Secernentea	aman-2⁶ aman-3⁶	Alpha MANnosidase family member (aman-3)	35(a) 27(a)	1 ↔ many possible ortholog	V(11927633-11933306) I(5324514-5330215)
thale cress (Arabidopsis thaliana)	eudicotyledons	GMII¹	alpha-mannosidase II	48.77(n) 44.21(a)		831347 NM_121499.2 NP_196999.1
rice (Oryza sativa)	Liliopsida	Os06g0245700¹	hypothetical protein	50.05(n) 43.86(a)		4340636 NM_001063812.2 NP_001057277.2

ENSEMBL Gene Tree for MAN2A2 (if available)
TreeFam Gene Tree for MAN2A2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for MAN2A2 gene

MAN2B1² MAN2B2² MAN2A1²

2 SIMAP similar genes for MAN2A2 using alignment to 16 protein entries: MA2A2_HUMAN (see all proteins):

MAN2A1 MANB

MAN2A2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144260754^1,2		--	91445539(+)	`CACTCA/GCTGGC`	1	--	us2k¹		0	--	--	--	--
rs148300898^1,2		--	91445540(+)	`ACTCGC/TTGGCA`	1	--	us2k¹		0	--	--	--	--
rs2677741^1,2	C	--	91445794(+)	`CTCCTG/AAGGTT`	1	--	us2k¹		2		WA	120
rs182598519^1,2		--	91445949(+)	`CGGCTA/GTCCCC`	1	--	us2k¹		0	--	--	--	--
rs71407344^1,2	C	--	91445976(+)	`GGCCCG/TGCAGC`	1	--	us2k¹		1		NA	2
rs143056962^1,2		--	91446225(+)	`GCGCGC/TGCGGG`	1	--	us2k¹		0	--	--	--	--
rs28446644^1,2	F	--	91446316(+)	`GGGACA/TGGAGG`	1	--	us2k¹		1		WA	118
rs734252^1,2	C,F,A,H	--	91446472(-)	`GGCCAG/ATGTGG`	1	--	us2k¹ tfbs³		28		NA EA MN NS WA CSA	2823
rs191451708^1,2		--	91446473(+)	`CACATC/TGGCCT`	1	--	us2k¹		0	--	--	--	--
rs183724958^1,2		--	91446525(+)	`CCGAGA/CAGAAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MAN2A2 (91445448 - 91465815 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MAN2A2
2 CNVs: 49620 4909
Human Gene Mutation Database (HGMD): MAN2A2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MAN2A2 for disorders           About GeneDecksing

OMIM gene information: 600988    OMIM disorders: --

4 diseases for MAN2A2:    About MalaCards

mannosidosis adhd immunodeficiency neuronitis

Export disorders for MAN2A2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MAN2A2 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with MAN2A2)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and expression of cDNAs encoding human alpha- mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme. (PubMed id 8524845)^{1, 2, 3, 9} Misago M....Fukuda M.N. (1995)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{1, 2} Hillman R.T.... Brenner S.E. (2004)
HIV-1 gp120 N-linked glycosylation differs between pla sma and leukocyte compartments. (PubMed id 18215327)¹ Ho Y.S....Saksena N.K. (2008)
Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)¹ Lesch K.P....Jacob C. (2008)
Glycosylation site-specific analysis of HIV envelope proteins (JR-FL and CON-S) reveals major differences in glycosylation site occupancy, glycoform profiles, and antigenic epitopes' accessibility. (PubMed id 18330979)¹ Go E.P....Desaire H. (2008)
Env length and N-linked glycosylation following transm ission of human immunodeficiency virus Type 1 subtype B viruses. (PubMed id 18314154)¹ Liu Y....Mullins J.I. (2008)
Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)² Zody M.C....Nusbaum C. (2006)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4122	HGNC: 6825	AceView: MAN2A2	Ensembl:ENSG00000196547	euGenes: HUgn4122
ECgene: MAN2A2	Kegg: 4122	H-InvDB: MAN2A2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MAN2A2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MAN2A2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MAN2A2 gene:
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GeneCards and IP:
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mannosidase, alpha, class 2A, member 2

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MAN2A2 Gene

mannosidase, alpha, class 2A, member 2

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