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Aliases for MAN2A2 Gene

Aliases for MAN2A2 Gene

  • Mannosidase Alpha Class 2A Member 2 2 3 4 5
  • Mannosyl-Oligosaccharide 1,3-1,6-Alpha-Mannosidase 3 4
  • Alpha-Mannosidase IIx 3 4
  • EC 3.2.1.114 4 61
  • MANA2X 3 4
  • Mannosidase, Alpha, Class 2A, Member 2 2
  • Manosidase, Alpha-, Type II, Isozyme X 3
  • Mannosidase, Alpha Type II-X 3
  • Alpha-Mannosidase 2x 3
  • MAN IIx 3
  • Man IIx 4

External Ids for MAN2A2 Gene

Previous GeneCards Identifiers for MAN2A2 Gene

  • GC15P087634
  • GC15P084886
  • GC15P089033
  • GC15P089175
  • GC15P089247
  • GC15P091447
  • GC15P067558

Summaries for MAN2A2 Gene

GeneCards Summary for MAN2A2 Gene

MAN2A2 (Mannosidase Alpha Class 2A Member 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include carbohydrate binding and alpha-mannosidase activity. An important paralog of this gene is MAN2A1.

UniProtKB/Swiss-Prot for MAN2A2 Gene

  • Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.

Tocris Summary for MAN2A2 Gene

  • Glycosylases are a group of enzymes that includes glucosidases, mannosidases and heparanases. There are two glucosidase subtypes, both found in the gut. They hydrolyze terminal (1,4)alpha-glucosidic linkages and (1,6)beta-glucosidic linkages, liberating alpha-glucose and beta-glucose.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAN2A2 Gene

Genomics for MAN2A2 Gene

Regulatory Elements for MAN2A2 Gene

Enhancers for MAN2A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F090835 1.7 FANTOM5 Ensembl ENCODE 11.7 -63.2 -63150 7.3 ATF1 ARNT YY1 GTF3C2 GLIS2 ELK1 GATA2 FOS NCOA1 REST FES BLM FURIN LOC101926911 LOC100631255 UNC45A MAN2A2 HDDC3 ENSG00000200677 ENSG00000259314
GH15F090813 1.3 FANTOM5 Ensembl ENCODE 11.9 -85.4 -85374 7.1 CTCF PKNOX1 KLF17 EBF1 RAD21 ZIC2 ZFHX2 POLR2A ZNF600 CHD2 BLM FES MAN2A2 ENSG00000200677 CRTC3 GC15M090794 PIR44829
GH15F090928 1.2 ENCODE 12.5 +28.7 28656 4.6 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 RCCD1 UNC45A MAN2A2 FES HDDC3
GH15F090662 1.3 Ensembl ENCODE 11.2 -237.1 -237053 4.9 HDGF ATF1 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF121 ENSG00000259314 FES MAN2A2 BLM ENSG00000259212 RCCD1 ENSG00000200677 GABARAPL3 ZNF774 LINC01585
GH15F090656 1.3 Ensembl ENCODE 11.2 -242.5 -242467 5.9 HDGF PKNOX1 ATF1 ARNT WRNIP1 ZNF133 GATA2 FOS ZNF263 JUNB BLM FES MAN2A2 CRTC3 ENSG00000200677 ZNF774 GABARAPL3 IQGAP1 LINC01585 GC15M090654
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MAN2A2 on UCSC Golden Path with GeneCards custom track

Promoters for MAN2A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000413480 782 2001 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for MAN2A2 Gene

Chromosome:
15
Start:
90,902,218 bp from pter
End:
90,922,585 bp from pter
Size:
20,368 bases
Orientation:
Plus strand

Genomic View for MAN2A2 Gene

Genes around MAN2A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAN2A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAN2A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAN2A2 Gene

Proteins for MAN2A2 Gene

  • Protein details for MAN2A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49641-MA2A2_HUMAN
    Recommended name:
    Alpha-mannosidase 2x
    Protein Accession:
    P49641
    Secondary Accessions:
    • A6NH12
    • A8K1E8
    • Q13754

    Protein attributes for MAN2A2 Gene

    Size:
    1150 amino acids
    Molecular mass:
    130539 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Alternative splice isoforms for MAN2A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAN2A2 Gene

Selected DME Specific Peptides for MAN2A2 Gene

P49641:
  • CCQFDFKR
  • HYFALIDQLIEGHQWLE
  • VFVVPHSHNDPGW
  • SGAYLFLP
  • TSRPFYK
  • KLPLQAN
  • LLDQYRKKS

Post-translational modifications for MAN2A2 Gene

  • Glycosylation at Asn 95, Asn 305, Asn 1082, and Asn 1120
  • Modification sites at PhosphoSitePlus

Domains & Families for MAN2A2 Gene

Gene Families for MAN2A2 Gene

Graphical View of Domain Structure for InterPro Entry

P49641

UniProtKB/Swiss-Prot:

MA2A2_HUMAN :
  • Belongs to the glycosyl hydrolase 38 family.
Family:
  • Belongs to the glycosyl hydrolase 38 family.
genes like me logo Genes that share domains with MAN2A2: view

Function for MAN2A2 Gene

Molecular function for MAN2A2 Gene

GENATLAS Biochemistry:
alpha-mannosidase,class 2A,member 2,membrane type,Golgi,housekeeping gene involved in processing of Asp-linked (N) glycans
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3).
UniProtKB/Swiss-Prot Function:
Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.

Enzyme Numbers (IUBMB) for MAN2A2 Gene

Gene Ontology (GO) - Molecular Function for MAN2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA --
GO:0004559 alpha-mannosidase activity IBA --
GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity TAS --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MAN2A2: view
genes like me logo Genes that share phenotypes with MAN2A2: view

Animal Models for MAN2A2 Gene

MGI Knock Outs for MAN2A2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAN2A2 Gene

Localization for MAN2A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAN2A2 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MAN2A2 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MAN2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MAN2A2: view

Pathways & Interactions for MAN2A2 Gene

genes like me logo Genes that share pathways with MAN2A2: view

UniProtKB/Swiss-Prot P49641-MA2A2_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for MAN2A2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000353655%0d%0a9606.ENSP00000311888%0d%0a9606.ENSP00000307423%0d%0a9606.ENSP00000416097%0d%0a9606.ENSP00000324105%0d%0a9606.ENSP00000262265%0d%0a
Selected Interacting proteins: P49641-MA2A2_HUMAN ENSP00000353655 for MAN2A2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for MAN2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006013 mannose metabolic process IBA --
GO:0006486 protein glycosylation IEA --
GO:0006491 N-glycan processing IBA --
GO:0006517 protein deglycosylation IBA --
genes like me logo Genes that share ontologies with MAN2A2: view

No data available for SIGNOR curated interactions for MAN2A2 Gene

Drugs & Compounds for MAN2A2 Gene

(5) Drugs for MAN2A2 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Acarbose Approved, Investigational Pharma Alpha-glucosidase inhibitor, Glucosidase alpha inhibitor (intestinal) 85
1-Deoxynojirimycin Experimental Pharma Glucosidase I and II inhibitor 26
Kifunensine Experimental Pharma Inhibitor of class I alpha-mannosidases 0
Swainsonine Experimental Pharma Inhibitor of alpha-mannosidase II 0

(2) Additional Compounds for MAN2A2 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Mannose
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
3458-28-4
Miglustat hydrochloride
210110-90-0

(5) Tocris Compounds for MAN2A2 Gene

Compound Action Cas Number
1-Deoxynojirimycin Glucosidase I and II inhibitor 19130-96-2
Acarbose Glucosidase alpha inhibitor (intestinal) 56180-94-0
Kifunensine Inhibitor of class I alpha-mannosidases 109944-15-2
Miglustat hydrochloride alpha-glucosidase I and II inhibitor. Also inhibits ceramide-specific glycosyltransferases 210110-90-0
Swainsonine Inhibitor of alpha-mannosidase II 72741-87-8
genes like me logo Genes that share compounds with MAN2A2: view

Transcripts for MAN2A2 Gene

Unigene Clusters for MAN2A2 Gene

Mannosidase, alpha, class 2A, member 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAN2A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a ·
SP1: - - - - - -
SP2: - - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14: - - -
SP15:
SP16: - - - -
SP17: - - - - - - -
SP18: -
SP19: - -
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:

ExUns: 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c ^ 20a · 20b · 20c ^ 21a · 21b · 21c · 21d · 21e ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - - -
SP5: -
SP6: - - -
SP7: - -
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22: -
SP23: -
SP24:
SP25:
SP26:

ExUns: 28a · 28b · 28c ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b · 32c ^ 33a · 33b · 33c · 33d · 33e · 33f · 33g
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5:
SP6: - - - -
SP7: - - - - -
SP8: - - -
SP9:
SP10: - - - - - - - -
SP11: - - - -
SP12: - - -
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24: - - -
SP25:
SP26:

Relevant External Links for MAN2A2 Gene

GeneLoc Exon Structure for
MAN2A2
ECgene alternative splicing isoforms for
MAN2A2

Expression for MAN2A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MAN2A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAN2A2 Gene

This gene is overexpressed in Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for MAN2A2 Gene

This gene is overexpressed in Serum (36.2), Peripheral blood mononuclear cells (11.4), and Cerebrospinal fluid (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MAN2A2 Gene



NURSA nuclear receptor signaling pathways regulating expression of MAN2A2 Gene:

MAN2A2

SOURCE GeneReport for Unigene cluster for MAN2A2 Gene:

Hs.116459
genes like me logo Genes that share expression patterns with MAN2A2: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MAN2A2 Gene

Orthologs for MAN2A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAN2A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAN2A2 34 35
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia MAN2A2 34 35
  • 90.03 (n)
cow
(Bos Taurus)
Mammalia MAN2A2 34 35
  • 89.39 (n)
mouse
(Mus musculus)
Mammalia Man2a2 34 16 35
  • 86.63 (n)
rat
(Rattus norvegicus)
Mammalia Man2a2 34
  • 86.35 (n)
oppossum
(Monodelphis domestica)
Mammalia MAN2A2 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 81 (a)
OneToMany
-- 35
  • 80 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves MAN2A2 34 35
  • 77.74 (n)
lizard
(Anolis carolinensis)
Reptilia MAN2A2 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia man2a2 34
  • 71.08 (n)
zebrafish
(Danio rerio)
Actinopterygii man2a2 34 35
  • 67.86 (n)
fruit fly
(Drosophila melanogaster)
Insecta alpha-Man-II 34 35
  • 50.96 (n)
alpha-Man-IIb 36
  • 40 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004020 34
  • 50.2 (n)
worm
(Caenorhabditis elegans)
Secernentea aman-2 34 35
  • 47.68 (n)
aman-3 35
  • 29 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons GMII 34
  • 48.77 (n)
rice
(Oryza sativa)
Liliopsida Os06g0245700 34
  • 50.61 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
Species where no ortholog for MAN2A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAN2A2 Gene

ENSEMBL:
Gene Tree for MAN2A2 (if available)
TreeFam:
Gene Tree for MAN2A2 (if available)

Paralogs for MAN2A2 Gene

Variants for MAN2A2 Gene

Sequence variations from dbSNP and Humsavar for MAN2A2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10048033 -- 90,921,745(+) GAAAC(C/G)CTGTG nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs10532338 -- 90,908,596(+) TTTAA(-/T)TTTTT intron-variant
rs1057105 -- 90,908,267(+) TGAAA(A/G)GCTTA intron-variant
rs1059891 -- 90,920,939(+) ATTAA(A/C)ACTCT nc-transcript-variant, utr-variant-3-prime
rs11073957 -- 90,901,343(+) AGAGA(G/T)AGCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAN2A2 Gene

Variant ID Type Subtype PubMed ID
nsv833090 CNV loss 17160897
nsv833089 CNV loss 17160897
nsv515661 CNV loss 19592680
esv3370257 CNV duplication 20981092

Variation tolerance for MAN2A2 Gene

Residual Variation Intolerance Score: 4.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.42; 77.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAN2A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MAN2A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAN2A2 Gene

Disorders for MAN2A2 Gene

Relevant External Links for MAN2A2

Genetic Association Database (GAD)
MAN2A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAN2A2

No disorders were found for MAN2A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAN2A2 Gene

Publications for MAN2A2 Gene

  1. Molecular cloning and expression of cDNAs encoding human alpha- mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme. (PMID: 8524845) Misago M. … Fukuda M.N. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 22 64
  2. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PMID: 18839057) Lesch K.P. … Jacob C. (J Neural Transm 2008) 3 46 64
  3. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for MAN2A2 Gene

Sources for MAN2A2 Gene

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