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MAN2A2 Gene

protein-coding   GIFtS: 62
GCID: GC15P091447

Mannosidase, Alpha, Class 2A, Member 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mannosidase, Alpha, Class 2A, Member 21 2     EC 3.2.1.1143 8
MANA2X2 3 5     Alpha-Mannosidase 2x2
Alpha-Mannosidase IIx2 3     Mannosidase, Alpha Type II-X2
Man IIx2 3     Manosidase, Alpha-, Type II, Isozyme X2
Mannosyl-Oligosaccharide 1,3-1,6-Alpha-Mannosidase2 3     Mannosidase Alpha Class 2A Member 23

External Ids:    HGNC: 68251   Entrez Gene: 41222   Ensembl: ENSG000001965477   OMIM: 6009885   UniProtKB: P496413   

Export aliases for MAN2A2 gene to outside databases

Previous GC identifers: GC15P087634 GC15P084886 GC15P089033 GC15P089175 GC15P089247 GC15P067558


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MAN2A2 Gene:
MAN2A2 (mannosidase, alpha, class 2A, member 2) is a protein-coding gene. Diseases associated with MAN2A2 include hiv-1, and malaria. GO annotations related to this gene include carbohydrate binding and mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity. An important paralog of this gene is MAN2B1.

UniProtKB/Swiss-Prot: MA2A2_HUMAN, P49641
Function: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of
high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway

summary for MAN2A2 Gene:
Mannosidases are divided into two subtypes; I and II, (EC numbers 3.2.1.113 and 3.2.1.114 respectively)
which display a wide expression pattern. Mannosidase I hydrolyzes (1,2)-linked alpha-D-mannose residues in
the oligo-mannose oligosaccharide Man9(GlcNAc)2 and mannosidase II hydrolyzes (1,3)- and (1,6)-linked
alpha-D-mannose residues in Man5(GlcNAc)3. Both subtypes require a divalent cation cofactor. Mutations in
mannosidases can cause mannosidosis (mannosidase I deficiency).




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAN2A2 gene promoter:
         NF-1/L   NF-1   Nkx2-5   E47   c-Ets-1   CREB   Ik-2   STAT3   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAN2A2 promoter sequence
   Search Chromatin IP Primers for MAN2A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAN2A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q25

MAN2A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAN2A2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P091447:  view genomic region     (about GC identifiers)

Start:
91,445,448 bp from pter      End:
91,465,815 bp from pter
Size:
20,368 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MA2A2_HUMAN, P49641 (See protein sequence)
Recommended Name: Alpha-mannosidase 2x  
Size: 1150 amino acids; 130539 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Homodimer; disulfide-linked (By similarity)
Secondary accessions: A6NH12 A8K1E8 Q13754
Alternative splicing: 3 isoforms:  P49641-3   P49641-1   P49641-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for MAN2A2: NX_P49641

Explore proteomics data for MAN2A2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn95, Asn305, Asn1082, Asn1120
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for MAN2A2 (P49641) (see all 7)
     TSRPFYK  KLPLQAN  CCQFDFKR  SGAYLFLP 


    See MAN2A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006113.2  
    ENSEMBL proteins: 
     ENSP00000453740   ENSP00000452691   ENSP00000453078   ENSP00000453999   ENSP00000452631  
     ENSP00000452948   ENSP00000453956   ENSP00000452897   ENSP00000453140   ENSP00000452866  
     ENSP00000452928   ENSP00000452813   ENSP00000453253   ENSP00000453341   ENSP00000453659  
     ENSP00000353655   ENSP00000388221   ENSP00000394372  
    Reactome Protein details: P49641

    MAN2A2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Custom MassSpec
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAN2A2

    MAN2A2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MAN2A2
    Novus Biologicals MAN2A2 Antibodies
    Abcam antibodies for MAN2A2
    Cloud-Clone Corp. Antibodies for MAN2A2
    Search ThermoFisher Antibodies for MAN2A2
    LSBio Antibodies in human, mouse, rat for MAN2A2

    MAN2A2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MAN2A2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MAN2A2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAN2A2
    Cloud-Clone Corp. CLIAs for MAN2A2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR027291 Glyco_hydro_38/57_N
     IPR011682 Glyco_hydro_38_C
     IPR015341 Glyco_hydro_38_cen
     IPR000602 Glyco_hydro_38_N
     IPR011013 Gal_mutarotase_SF_dom

    Graphical View of Domain Structure for InterPro Entry P49641

    ProtoNet protein and cluster: P49641

    1 Blocks protein domain: IPB000602 Glycoside hydrolase

    UniProtKB/Swiss-Prot: MA2A2_HUMAN, P49641
    Similarity: Belongs to the glycosyl hydrolase 38 family


    MAN2A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MA2A2_HUMAN, P49641
    Function: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of
    high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway
    Catalytic activity: Hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the
    mannosyl-oligosaccharide Man(5)(GlcNAc)(3)

         Genatlas biochemistry entry for MAN2A2:
    alpha-mannosidase,class 2A,member 2,membrane type,Golgi,housekeeping gene involved in processing of Asp-linked (N)
    glycans

         Enzyme Number (IUBMB): EC 3.2.1.1141 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004553hydrolase activity, hydrolyzing O-glycosyl compounds ----
    GO:0004559alpha-mannosidase activity ----
    GO:0004572mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    MAN2A2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MAN2A2:
     G0/1 arrest  Increased G1 DNA content 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Man2a2):
     endocrine/exocrine gland  liver/biliary system  mortality/aging  renal/urinary system  reproductive system 
     respiratory system 

    MAN2A2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Man2a2tm1Mfu for MAN2A2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MAN2A2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MAN2A2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAN2A2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAN2A2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MAN2A2:
    hsa-mir-484 (MIRT042114), hsa-mir-192-5p (MIRT026963), hsa-mir-215-5p (MIRT024425)

    Block miRNA regulation of human, mouse, rat MAN2A2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAN2A2 (see all 19):
    hsa-miR-345 hsa-miR-148b* hsa-miR-3616-5p hsa-miR-128 hsa-miR-501-5p hsa-miR-3182 hsa-miR-27a hsa-miR-324-3p
    SwitchGear 3'UTR luciferase reporter plasmidMAN2A2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAN2A2
    Predesigned siRNA for gene silencing in human, mouse, rat MAN2A2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MAN2A2

    Clone
    Products:
         
    OriGene clones in human, mouse for MAN2A2 (see all 7)
    OriGene ORF clones in mouse, rat for MAN2A2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAN2A2 (NM_006122)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAN2A2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAN2A2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MAN2A2
    Browse ESI BIO Cell Lines and PureStem Progenitors for MAN2A2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAN2A2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MA2A2_HUMAN, P49641: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular2
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral component of membrane IEA--

    MAN2A2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAN2A2 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Metabolism of proteins0.30
    N-Glycan biosynthesis0.49
    N-glycan antennae elongation in the medial/trans-Golgi0.00
    Post-translational protein modification0.43
    Reactions specific to the complex N-glycan synthesis pathway0.00
    Transport to the Golgi and subsequent modification0.40
    2Metabolism
    Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for MAN2A2
        Reactions specific to the complex N-glycan synthesis pathway


    2 Kegg Pathways  (Kegg details for MAN2A2):
        N-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: MA2A2_HUMAN, P49641
    Pathway: Protein modification; protein glycosylation


    MAN2A2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including MAN2A2: 

              Glycosylation in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for MAN2A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for MAN2A2 (P496412, 3 ENSP000003536554) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C7orf55-LUC7L2Q9Y3832, 3MINT-63782 I2D: score=5 
    LUC7L2Q9Y3832, 3MINT-63782 I2D: score=5 
    CHD3Q128732, 3MINT-63783 I2D: score=5 
    GIT1Q9Y2X72, 3MINT-63781 I2D: score=5 
    VIMP086702, 3MINT-63780 I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006013mannose metabolic process IEA--
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    MAN2A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for MAN2A2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    KifunensineInhibitor of class I alpha-mannosidases[109944-15-2]
    1-DeoxynojirimycinGlucosidase I and II inhibitor[19130-96-2]
    1-Deoxymannojirimycin hydrochloridealpha-Mannosidase I inhibitor[73465-43-7]
    Miglitolalpha-glucosidase inhibitor[72432-03-2]
    OGT 2115Antiangiogenic. Heparanase inhibitor[853929-59-6]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MAN2A2 gene: 
    NM_006122.2  

    Unigene Cluster for MAN2A2:

    Mannosidase, alpha, class 2A, member 2
    Hs.116459  [show with all ESTs]
    Unigene Representative Sequence: NM_006122
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32):
    ENST00000558290 ENST00000558853 ENST00000559999 ENST00000560534 ENST00000560451
    ENST00000558161 ENST00000559717(uc010bnz.2 uc010uqn.1) ENST00000559965
    ENST00000560192(uc010boa.3) ENST00000559132 ENST00000558640 ENST00000561046
    ENST00000557865 ENST00000560616 ENST00000558171 ENST00000561240 ENST00000560505
    ENST00000559374
    miRNA
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    Block miRNA regulation of human, mouse, rat MAN2A2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAN2A2 (see all 19):
    hsa-miR-345 hsa-miR-148b* hsa-miR-3616-5p hsa-miR-128 hsa-miR-501-5p hsa-miR-3182 hsa-miR-27a hsa-miR-324-3p
    SwitchGear 3'UTR luciferase reporter plasmidMAN2A2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MAN2A2
    Predesigned siRNA for gene silencing in human, mouse, rat MAN2A2
    Clone
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    OriGene clones in human, mouse for MAN2A2 (see all 7)
    OriGene ORF clones in mouse, rat for MAN2A2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MAN2A2 (NM_006122)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAN2A2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAN2A2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MAN2A2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat MAN2A2
      QuantiTect SYBR Green Assays in human, mouse, rat MAN2A2
      QuantiFast Probe-based Assays in human, mouse, rat MAN2A2

    Additional mRNA sequence: 

    AF116691.1 AK289863.1 AK293799.1 AK295646.1 AK299213.1 AK308838.1 AK316150.1 AL110288.1 
    AL832306.1 BC136448.1 BC144111.1 D55649.1 L28821.1 

    18 DOTS entries:

    DT.100779139  DT.218593  DT.121075755  DT.121075752  DT.121075746  DT.95213617  DT.97857466  DT.91759945 
    DT.100659118  DT.92051263  DT.95276395  DT.121075712  DT.121075743  DT.100864734  DT.210478  DT.91798153 
    DT.91908857  DT.92459568 

    Selected AceView cDNA sequences (see all 253):

    AW469434 AA984120 BQ267491 BQ424705 BM668631 T17169 T17279 BG403870 
    AI361497 BQ876822 AA662481 D55649 AL832306 CD622022 CD364844 CA442098 
    BU149770 CK819674 T36081 T30752 AA365033 AW468565 AA383137 BE819791 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MAN2A2 (see all 26)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a ·
    SP1:                          -     -     -     -     -     -                                                                                                   
    SP2:                          -     -     -     -     -     -                                                                                                   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c ^ 20a · 20b · 20c ^ 21a · 21b · 21c · 21d · 21e ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^
    SP1:                                      -     -                 -           -                                               -                 -     -     -   
    SP2:                                      -     -                 -           -     -                                         -                 -     -     -   
    SP3:                                                                                                                                            -     -     -   
    SP4:                                                                                                                    -     -                 -     -     -   
    SP5:                                      -                                                                                                                     

    ExUns: 28a · 28b · 28c ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b · 32c ^ 33a · 33b · 33c · 33d · 33e · 33f · 33g
    SP1:  -                 -     -     -                 -                                                         
    SP2:  -                 -     -     -                 -                                                         
    SP3:  -                 -     -     -                 -                                                         
    SP4:  -                 -     -     -                 -                                                         
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for MAN2A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAN2A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MAN2A2 Expression
    About this image

    MAN2A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAN2A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.116459
        Pathway & Disease-focused RT2 Profiler PCR Array including MAN2A2: 
              Glycosylation in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAN2A2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Man2a21 , 5 mannosidase 2, alpha 21, 5 86.63(n)1
    89.9(a)1
      7 (45.65 cM)5
    1404811  NM_172903.41  NP_766491.21 
     803490985 
    chicken
    (Gallus gallus)
    Aves MAN2A21 mannosidase, alpha, class 2A, member 2 77.74(n)
    78.99(a)
      415585  XM_001233607.3  XP_001233608.2 
    lizard
    (Anolis carolinensis)
    Reptilia MAN2A26
    mannosidase, alpha, class 2A, member 2
    76(a)
    1 ↔ 1
    GL343759.1(77741-97693)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia man2a21 mannosidase, alpha, class 2A, member 2 71.08(n)
    76.63(a)
      448465  NM_001006776.1  NP_001006777.1 
    zebrafish
    (Danio rerio)
    Actinopterygii man2a21 mannosidase, alpha, class 2A, member 2 67.86(n)
    68.9(a)
      100333987  XM_005162983.1  XP_005163040.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta alpha-Man-IIb3
    alpha-Man-II1
    alpha-mannosidase3
    alpha Mannosidase II1
    40(a)3
    50.96(n)1
    42.52(a)1
      89A53
    411261  NM_079567.31  NP_524291.21 
    worm
    (Caenorhabditis elegans)
    Secernentea aman-21 aman-2 47.68(n)
    42.84(a)
      179632  NM_073594.3  NP_505995.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GMII1 GMII 48.77(n)
    44.21(a)
      831347  NM_121499.2  NP_196999.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g02457001 Os06g0245700 50.61(n)
    44.48(a)
      4340636  NM_001063812.2  NP_001057277.2 


    ENSEMBL Gene Tree for MAN2A2 (if available)
    TreeFam Gene Tree for MAN2A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAN2A2 gene
    MAN2B12  MAN2B22  ENSG000002692422  ENSG000002695902  MAN2A12  
    3 SIMAP similar genes for MAN2A2 using alignment to 16 protein entries:     MA2A2_HUMAN (see all proteins):
    MAN2A1    MAN2B2    MANB

    MAN2A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAN2A2 (see all 682)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1852773781,2
    --71169733(+) CTTGAA/GGGATT 1 -- us2k10--------
    rs1899902421,2
    --71169777(+) AGATAA/TTGTTA 1 -- us2k10--------
    rs1442607541,2
    --91445539(+) CACTCA/GCTGGC 1 -- us2k10--------
    rs1483008981,2
    --91445540(+) ACTCGC/TTGGCA 1 -- us2k10--------
    rs26777411,2
    C,F--91445794(+) CTCCTG/AAGGTT 1 -- us2k12Minor allele frequency- A:0.04WA 120
    rs1825985191,2
    C--91445949(+) CGGCTA/GTCCCC 1 -- us2k10--------
    rs714073441,2
    C,F--91445976(+) GGCCCG/TGCAGC 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1430569621,2
    --91446225(+) GCGCGC/TGCGGG 1 -- us2k10--------
    rs284466441,2
    C,F--91446316(+) GGGACA/TGGAGG 1 -- us2k11Minor allele frequency- T:0.36WA 118
    rs7342521,2
    C,F,A,H--91446472(-) GGCCAG/ATGTGG 1 -- us2k1 tfbs328Minor allele frequency- A:0.31NA EA MN NS WA CSA 2823

    HapMap Linkage Disequilibrium report for MAN2A2 (91445448 - 91465815 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MAN2A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833089CNV Loss17160897
    nsv515661CNV Loss19592680
    nsv833090CNV Loss17160897

    Human Gene Mutation Database (HGMD): MAN2A2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MAN2A2
    DNA2.0 Custom Variant and Variant Library Synthesis for MAN2A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600988    OMIM disorders: --

    2 diseases for MAN2A2:    
    About MalaCards
    hiv-1    malaria


    MAN2A2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MAN2A2

    Export disorders for MAN2A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAN2A2 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with MAN2A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of cDNAs encoding human alpha- mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme. (PubMed id 8524845)1, 2, 3, 9 Misago M....Fukuda M.N. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    2. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)1, 4 Lesch K.P....Jacob C. (J Neural Transm 2008)
    3. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    6. HIV-1 gp120 N-linked glycosylation differs between plasma and leukocyte compartments. (PubMed id 18215327)1 Ho Y.S....Saksena N.K. (Virol. J. 2008)
    7. Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses. (PubMed id 18314154)1 Liu Y....Mullins J.I. (Virology 2008)
    8. Glycosylation site-specific analysis of HIV envelope proteins (JR-FL and CON-S) reveals major differences in glycosylation site occupancy, glycoform profiles, and antigenic epitopes' accessibility. (PubMed id 18330979)1 Go E.P....Desaire H. (J. Proteome Res. 2008)
    9. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (Nature 2006)
    10. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4122 HGNC: 6825 AceView: MAN2A2 Ensembl:ENSG00000196547 euGenes: HUgn4122
    ECgene: MAN2A2 Kegg: 4122 H-InvDB: MAN2A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAN2A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAN2A2 gene:
    Search GeneIP for patents involving MAN2A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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