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Aliases for MAN2A2 Gene

Aliases for MAN2A2 Gene

  • Mannosidase, Alpha, Class 2A, Member 2 2 3
  • MANA2X 3 4 6
  • Mannosyl-Oligosaccharide 1,3-1,6-Alpha-Mannosidase 3 4
  • Alpha-Mannosidase IIx 3 4
  • EC 3.2.1.114 4 63
  • Manosidase, Alpha-, Type II, Isozyme X 3
  • Mannosidase Alpha Class 2A Member 2 4
  • Mannosidase, Alpha Type II-X 3
  • Alpha-Mannosidase 2x 3
  • MAN IIx 3
  • Man IIx 4

External Ids for MAN2A2 Gene

Previous GeneCards Identifiers for MAN2A2 Gene

  • GC15P087634
  • GC15P084886
  • GC15P089033
  • GC15P089175
  • GC15P089247
  • GC15P091447
  • GC15P067558

Summaries for MAN2A2 Gene

GeneCards Summary for MAN2A2 Gene

MAN2A2 (Mannosidase, Alpha, Class 2A, Member 2) is a Protein Coding gene. Diseases associated with MAN2A2 include mannosidosis. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include carbohydrate binding and mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity. An important paralog of this gene is MAN2B1.

UniProtKB/Swiss-Prot for MAN2A2 Gene

  • Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway

Tocris Summary for MAN2A2 Gene

  • Mannosidases are divided into two subtypes; I and II, (EC numbers 3.2.1.113 and 3.2.1.114 respectively) which display a wide expression pattern. Mannosidase I hydrolyzes (1,2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2 and mannosidase II hydrolyzes (1,3)- and (1,6)-linked alpha-D-mannose residues in Man5(GlcNAc)3. Both subtypes require a divalent cation cofactor. Mutations in mannosidases can cause mannosidosis (mannosidase I deficiency).

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAN2A2 Gene

Genomics for MAN2A2 Gene

Regulatory Elements for MAN2A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAN2A2 Gene

Start:
90,902,218 bp from pter
End:
90,922,585 bp from pter
Size:
20,368 bases
Orientation:
Plus strand

Genomic View for MAN2A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAN2A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAN2A2 Gene

Proteins for MAN2A2 Gene

  • Protein details for MAN2A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49641-MA2A2_HUMAN
    Recommended name:
    Alpha-mannosidase 2x
    Protein Accession:
    P49641
    Secondary Accessions:
    • A6NH12
    • A8K1E8
    • Q13754

    Protein attributes for MAN2A2 Gene

    Size:
    1150 amino acids
    Molecular mass:
    130539 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Alternative splice isoforms for MAN2A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAN2A2 Gene

Proteomics data for MAN2A2 Gene at MOPED

Selected DME Specific Peptides for MAN2A2 Gene

Post-translational modifications for MAN2A2 Gene

  • Glycosylation at Asn95, Asn305, Asn1082, and Asn1120
  • Modification sites at PhosphoSitePlus

Domains for MAN2A2 Gene

Graphical View of Domain Structure for InterPro Entry

P49641

UniProtKB/Swiss-Prot:

MA2A2_HUMAN :
  • P49641
Family:
  • Belongs to the glycosyl hydrolase 38 family.
genes like me logo Genes that share domains with MAN2A2: view

No data available for Gene Families for MAN2A2 Gene

Function for MAN2A2 Gene

Molecular function for MAN2A2 Gene

GENATLAS Biochemistry: alpha-mannosidase,class 2A,member 2,membrane type,Golgi,housekeeping gene involved in processing of Asp-linked (N) glycans
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3)
UniProtKB/Swiss-Prot Function: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway

Enzyme Numbers (IUBMB) for MAN2A2 Gene

Gene Ontology (GO) - Molecular Function for MAN2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds --
GO:0004559 alpha-mannosidase activity --
GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MAN2A2: view
genes like me logo Genes that share phenotypes with MAN2A2: view

Animal Models for MAN2A2 Gene

MGI Knock Outs for MAN2A2:

Animal Model Products

CRISPR Products

miRNA for MAN2A2 Gene

miRTarBase miRNAs that target MAN2A2

No data available for Transcription Factor Targeting and HOMER Transcription for MAN2A2 Gene

Localization for MAN2A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAN2A2 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAN2A2 Gene COMPARTMENTS Subcellular localization image for MAN2A2 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MAN2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MAN2A2: view

Pathways for MAN2A2 Gene

genes like me logo Genes that share pathways with MAN2A2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P49641-MA2A2_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for MAN2A2 Gene

Gene Ontology (GO) - Biological Process for MAN2A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0006013 mannose metabolic process IEA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MAN2A2: view

Compounds for MAN2A2 Gene

(5) Tocris Compounds for MAN2A2 Gene

Compound Action Cas Number
1-Deoxynojirimycin Glucosidase I and II inhibitor [19130-96-2]
Castanospermine Glucosidases alpha and beta inhibitor [79831-76-8]
Kifunensine Inhibitor of class I alpha-mannosidases [109944-15-2]
Miglustat hydrochloride alpha-glucosidase I and II inhibitor. Also inhibits ceramide-specific glycosyltransferases [210110-90-0]
Voglibose Orally active alpha-glucosidase inhibitor [83480-29-9]
genes like me logo Genes that share compounds with MAN2A2: view

Transcripts for MAN2A2 Gene

Unigene Clusters for MAN2A2 Gene

Mannosidase, alpha, class 2A, member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAN2A2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MAN2A2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAN2A2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a ·
SP1: - - - - - -
SP2: - - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14: - - -
SP15:
SP16: - - - -
SP17: - - - - - - -
SP18: -
SP19: - -
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:

ExUns: 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c ^ 20a · 20b · 20c ^ 21a · 21b · 21c · 21d · 21e ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - - -
SP5: -
SP6: - - -
SP7: - -
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22: -
SP23: -
SP24:
SP25:
SP26:

ExUns: 28a · 28b · 28c ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b · 32c ^ 33a · 33b · 33c · 33d · 33e · 33f · 33g
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5:
SP6: - - - -
SP7: - - - - -
SP8: - - -
SP9:
SP10: - - - - - - - -
SP11: - - - -
SP12: - - -
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24: - - -
SP25:
SP26:

Relevant External Links for MAN2A2 Gene

GeneLoc Exon Structure for
MAN2A2
ECgene alternative splicing isoforms for
MAN2A2

Expression for MAN2A2 Gene

mRNA expression in normal human tissues for MAN2A2 Gene

mRNA differential expression in normal tissues according to GTEx for MAN2A2 Gene

This gene is overexpressed in Whole Blood (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAN2A2 Gene

SOURCE GeneReport for Unigene cluster for MAN2A2 Gene Hs.116459

genes like me logo Genes that share expressions with MAN2A2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MAN2A2 Gene

Orthologs for MAN2A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAN2A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAN2A2 35
  • 99.51 (n)
  • 99.39 (a)
MAN2A2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAN2A2 35
  • 89.39 (n)
  • 92.09 (a)
MAN2A2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAN2A2 35
  • 90.03 (n)
  • 92.87 (a)
MAN2A2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Man2a2 35
  • 86.63 (n)
  • 89.9 (a)
Man2a2 16
Man2a2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAN2A2 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Man2a2 35
  • 86.35 (n)
  • 90.17 (a)
chicken
(Gallus gallus)
Aves MAN2A2 35
  • 77.74 (n)
  • 78.99 (a)
MAN2A2 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAN2A2 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia man2a2 35
  • 71.08 (n)
  • 76.63 (a)
zebrafish
(Danio rerio)
Actinopterygii man2a2 35
  • 67.86 (n)
  • 68.9 (a)
man2a2 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004020 35
  • 50.2 (n)
  • 41.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta alpha-Man-II 35
  • 50.96 (n)
  • 42.52 (a)
alpha-Man-II 36
  • 39 (a)
OneToMany
alpha-Man-IIb 37
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea aman-2 35
  • 47.68 (n)
  • 42.84 (a)
aman-2 36
  • 37 (a)
ManyToMany
aman-3 36
  • 29 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons GMII 35
  • 48.77 (n)
  • 44.21 (a)
rice
(Oryza sativa)
Liliopsida Os06g0245700 35
  • 50.61 (n)
  • 44.48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for MAN2A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAN2A2 Gene

ENSEMBL:
Gene Tree for MAN2A2 (if available)
TreeFam:
Gene Tree for MAN2A2 (if available)

Paralogs for MAN2A2 Gene

Paralogs for MAN2A2 Gene

genes like me logo Genes that share paralogs with MAN2A2: view

Variants for MAN2A2 Gene

Sequence variations from dbSNP and Humsavar for MAN2A2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs4773 -- 90,920,612(-) AGAGC(C/T)CTTGG utr-variant-3-prime, nc-transcript-variant
rs734252 -- 90,903,242(-) GGCCA(A/G)TGTGG upstream-variant-2KB, utr-variant-5-prime
rs756977 -- 90,906,342(-) AGGAC(A/G)GAGCA intron-variant
rs877285 -- 90,908,974(-) gtgac(C/T)gtggg intron-variant
rs886209 -- 90,908,055(-) GAGCA(C/T)TGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAN2A2 Gene

Variant ID Type Subtype PubMed ID
nsv833089 CNV Loss 17160897
nsv515661 CNV Loss 19592680
nsv833090 CNV Loss 17160897

Relevant External Links for MAN2A2 Gene

HapMap Linkage Disequilibrium report
MAN2A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAN2A2 Gene

Disorders for MAN2A2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MAN2A2 Gene including...

Search for MAN2A2 Gene in MalaCards »

Relevant External Links for MAN2A2

Genetic Association Database (GAD)
MAN2A2
genes like me logo Genes that share disorders with MAN2A2: view

No data available for UniProtKB/Swiss-Prot for MAN2A2 Gene

Publications for MAN2A2 Gene

  1. Molecular cloning and expression of cDNAs encoding human alpha- mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme. (PMID: 8524845) Misago M. … Fukuda M.N. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 23
  2. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PMID: 18839057) Lesch K.P. … Jacob C. (J Neural Transm 2008) 3 48
  3. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4
  4. Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin. (PMID: 12560567) Hart M.L. … Spear G.T. (J. Gen. Virol. 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MAN2A2 Gene

Sources for MAN2A2 Gene

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