Aliases for MAN2A2 Gene
External Ids for MAN2A2 Gene
Previous GeneCards Identifiers for MAN2A2 Gene
GeneCards Summary for MAN2A2 Gene
MAN2A2 (Mannosidase, Alpha, Class 2A, Member 2) is a Protein Coding gene. Diseases associated with MAN2A2 include mannosidosis. Among its related pathways are Metabolism and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include carbohydrate binding and mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity. An important paralog of this gene is MAN2B1.
UniProtKB/Swiss-Prot for MAN2A2 Gene
Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway
Mannosidases are divided into two subtypes; I and II, (EC numbers 18.104.22.168 and 22.214.171.124 respectively) which display a wide expression pattern. Mannosidase I hydrolyzes (1,2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2 and mannosidase II hydrolyzes (1,3)- and (1,6)-linked alpha-D-mannose residues in Man5(GlcNAc)3. Both subtypes require a divalent cation cofactor. Mutations in mannosidases can cause mannosidosis (mannosidase I deficiency).