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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAN2A2 Gene

protein-coding   GIFtS: 60
GCID: GC15P091447

Mannosidase, Alpha, Class 2A, Member 2

  Search for MAN2A2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mannosidase, Alpha, Class 2A, Member 21 2     EC 3.2.1.1143 8
MANA2X2 3 5     Alpha-Mannosidase 2x2
Alpha-Mannosidase IIx2 3     Mannosidase, Alpha Type II-X2
Man IIx2 3     Manosidase, Alpha-, Type II, Isozyme X2
Mannosyl-Oligosaccharide 1,3-1,6-Alpha-Mannosidase2 3     Mannosidase Alpha Class 2A Member 23

External Ids:    HGNC: 68251   Entrez Gene: 41222   Ensembl: ENSG000001965477   OMIM: 6009885   UniProtKB: P496413   

Export aliases for MAN2A2 gene to outside databases

Previous GC identifers: GC15P087634 GC15P084886 GC15P089033 GC15P089175 GC15P089247 GC15P067558


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MAN2A2 Gene: 
MAN2A2 (mannosidase, alpha, class 2A, member 2) is a protein-coding gene. Among its related super-pathways are WNT ligand biogenesis and trafficking and N-Glycan antennae elongation. GO annotations related to this gene include carbohydrate binding and mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity. An important paralog of this gene is MAN2B1.

UniProtKB/Swiss-Prot: MA2A2_HUMAN, P49641
Function: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of
high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway

summary for MAN2A2 Gene:
Mannosidases are divided into two subtypes; I and II, (EC numbers 3.2.1.113 and 3.2.1.114 respectively)
which display a wide expression pattern. Mannosidase I hydrolyzes (1,2)-linked alpha-D-mannose residues in
the oligo-mannose oligosaccharide Man9(GlcNAc)2 and mannosidase II hydrolyzes (1,3)- and (1,6)-linked
alpha-D-mannose residues in Man5(GlcNAc)3. Both subtypes require a divalent cation cofactor. Mutations in
mannosidases can cause mannosidosis (mannosidase I deficiency).




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010274.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAN2A2 gene promoter:
         NF-1/L   NF-1   Nkx2-5   E47   c-Ets-1   CREB   Ik-2   STAT3   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAN2A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAN2A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAN2A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q25

MAN2A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAN2A2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P091447:  view genomic region     (about GC identifiers)

Start:
91,445,448 bp from pter      End:
91,465,815 bp from pter
Size:
20,368 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MA2A2_HUMAN, P49641 (See protein sequence)
Recommended Name: Alpha-mannosidase 2x  
Size: 1150 amino acids; 130539 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Homodimer; disulfide-linked (By similarity)
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Secondary accessions: A6NH12 A8K1E8 Q13754
Alternative splicing: 3 isoforms:  P49641-3   P49641-1   P49641-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for MAN2A2: NX_P49641

Explore proteomics data for MAN2A2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49641

  • 4/7 DME Specific Peptides for MAN2A2 (P49641) (see all 7)
     TSRPFYK  KLPLQAN  CCQFDFKR  SGAYLFLP 

    MAN2A2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAN2A2 Protein Expression
    REFSEQ proteins: NP_006113.2  
    ENSEMBL proteins: 
     ENSP00000453740   ENSP00000452691   ENSP00000453078   ENSP00000453999   ENSP00000452631  
     ENSP00000452948   ENSP00000453956   ENSP00000452897   ENSP00000453140   ENSP00000452866  
     ENSP00000452928   ENSP00000452813   ENSP00000453253   ENSP00000453341   ENSP00000453659  
     ENSP00000353655   ENSP00000388221   ENSP00000394372  
    Reactome Protein details: P49641
    Human Recombinant Protein Products for MAN2A2: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAN2A2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0016021integral to membrane IEA--

    MAN2A2 for ontologies           About GeneDecksing



    MAN2A2 Antibody Products: 
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    Novus Biologicals MAN2A2 Antibodies
    Abcam antibodies for MAN2A2
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    LSBio Antibodies in human, mouse, rat for MAN2A2 

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MAN2A2 
    Cloud-Clone Corp. CLIAs for MAN2A2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR027291 Glyco_hydro_38/57_N
     IPR011682 Glyco_hydro_38_C
     IPR015341 Glyco_hydro_38_cen_dom
     IPR000602 Glyco_hydro_38_N
     IPR011013 Gal_mutarotase_SF_dom

    Graphical View of Domain Structure for InterPro Entry P49641

    ProtoNet protein and cluster: P49641

    1 Blocks protein domain: IPB000602 Glycoside hydrolase

    UniProtKB/Swiss-Prot: MA2A2_HUMAN, P49641
    Similarity: Belongs to the glycosyl hydrolase 38 family


    MAN2A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MA2A2_HUMAN, P49641
    Function: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of
    high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway
    Catalytic activity: Hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the
    mannosyl-oligosaccharide Man(5)(GlcNAc)(3)

         Genatlas biochemistry entry for MAN2A2:
    alpha-mannosidase,class 2A,member 2,membrane type,Golgi,housekeeping gene involved in processing of Asp-linked (N)
    glycans

         Enzyme Number (IUBMB): EC 3.2.1.1141 2

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004553hydrolase activity, hydrolyzing O-glycosyl compounds ----
    GO:0004559alpha-mannosidase activity ----
    GO:0004572mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity NAS--
    GO:0008270zinc ion binding IEA--
         
    MAN2A2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MAN2A2:
     G0/1 arrest  Increased G1 DNA content 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Man2a2):
     endocrine/exocrine gland  liver/biliary system  mortality/aging  renal/urinary system  reproductive system 
     respiratory system 

    MAN2A2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Man2a2tm1Mfu for MAN2A2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAN2A2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAN2A2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAN2A2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAN2A2 

    miRNA
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    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate MAN2A2 (see all 19):
    hsa-miR-345 hsa-miR-148b* hsa-miR-3616-5p hsa-miR-128 hsa-miR-501-5p hsa-miR-3182 hsa-miR-27a hsa-miR-324-3p
    SwitchGear 3'UTR luciferase reporter plasmidMAN2A2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of MAN2A2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAN2A2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAN2A2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    N-Glycan biosynthesis0.52
    WNT ligand biogenesis and trafficking0.77
    Post-translational protein modification0.44
    Signaling by Wnt0.62
    Metabolism of proteins0.35
    2N-glycan antennae elongation in the medial/trans-Golgi
    N-glycan antennae elongation in the medial/trans-Golgi0.75
    Transport to the Golgi and subsequent modification0.56
    3Signaling by GPCR
    Signal Transduction0.55
    4Metabolism
    Metabolic pathways0.40
    5Reactions specific to the complex N-glycan synthesis pathway
    Reactions specific to the complex N-glycan synthesis pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/9        Reactome Pathways for MAN2A2 (see all 9)
        Reactions specific to the complex N-glycan synthesis pathway
    Signaling by Wnt
    Asparagine N-linked glycosylation
    N-glycan antennae elongation in the medial/trans-Golgi
    Transport to the Golgi and subsequent modification


    2         Kegg Pathways  (Kegg details for MAN2A2):
        N-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: MA2A2_HUMAN, P49641
    Pathway: Protein modification; protein glycosylation


    MAN2A2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAN2A2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/10 Interacting proteins for MAN2A2 (P496412, 3 ENSP000003536554) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    C7orf55-LUC7L2Q9Y3832, 3MINT-63782 I2D: score=5 
    LUC7L2Q9Y3832, 3MINT-63782 I2D: score=5 
    CHD3Q128732, 3MINT-63783 I2D: score=5 
    GIT1Q9Y2X72, 3MINT-63781 I2D: score=5 
    VIMP086702, 3MINT-63780 I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process NAS--
    GO:0006013mannose metabolic process IEA--
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    MAN2A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MAN2A2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    KifunensineInhibitor of class I alpha-mannosidases[109944-15-2]
    1-DeoxynojirimycinGlucosidase I and II inhibitor[19130-96-2]
    1-Deoxymannojirimycin hydrochloridealpha-Mannosidase I inhibitor[73465-43-7]
    Miglitolalpha-glucosidase inhibitor[72432-03-2]
    OGT 2115Antiangiogenic. Heparanase inhibitor[853929-59-6]

    Search CenterWatch for drugs/clinical trials and news about MAN2A2 / MA2A2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAN2A2 gene: 
    NM_006122.2  

    Unigene Cluster for MAN2A2:

    Mannosidase, alpha, class 2A, member 2
    Hs.116459  [show with all ESTs]
    Unigene Representative Sequence: NM_006122
    18/32 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32):
    ENST00000558290 ENST00000558853 ENST00000559999 ENST00000560534 ENST00000560451
    ENST00000558161 ENST00000559717(uc010bnz.2 uc010uqn.1) ENST00000559965
    ENST00000560192(uc010boa.3) ENST00000559132 ENST00000558640 ENST00000561046
    ENST00000557865 ENST00000560616 ENST00000558171 ENST00000561240 ENST00000560505
    ENST00000559374
    miRNA
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    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate MAN2A2 (see all 19):
    hsa-miR-345 hsa-miR-148b* hsa-miR-3616-5p hsa-miR-128 hsa-miR-501-5p hsa-miR-3182 hsa-miR-27a hsa-miR-324-3p
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAN2A2
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAN2A2

    Additional mRNA sequence: 

    AF116691.1 AK289863.1 AK293799.1 AK295646.1 AK299213.1 AK308838.1 AK316150.1 AL110288.1 
    AL832306.1 BC136448.1 BC144111.1 D55649.1 L28821.1 

    18 DOTS entries:

    DT.100779139  DT.218593  DT.121075755  DT.121075752  DT.121075746  DT.95213617  DT.97857466  DT.91759945 
    DT.100659118  DT.92051263  DT.95276395  DT.121075712  DT.121075743  DT.100864734  DT.210478  DT.91798153 
    DT.91908857  DT.92459568 

    24/253 AceView cDNA sequences (see all 253):

    T17279 T36081 AA662481 BM704460 BG403870 D55649 AI074362 CD622022 
    BE858352 AI424227 BM670196 AI216083 BX110391 CD364844 AW500018 BU149770 
    AI361497 BQ267491 BE378155 BQ424705 AA984120 AW468565 BE819791 CN480380 

    GeneLoc Exon Structure

    5/26 Alternative Splicing Database (ASD) splice patterns (SP) for MAN2A2 (see all 26)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a ·
    SP1:                          -     -     -     -     -     -                                                                                                   
    SP2:                          -     -     -     -     -     -                                                                                                   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b · 19c ^ 20a · 20b · 20c ^ 21a · 21b · 21c · 21d · 21e ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^
    SP1:                                      -     -                 -           -                                               -                 -     -     -   
    SP2:                                      -     -                 -           -     -                                         -                 -     -     -   
    SP3:                                                                                                                                            -     -     -   
    SP4:                                                                                                                    -     -                 -     -     -   
    SP5:                                      -                                                                                                                     

    ExUns: 28a · 28b · 28c ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b · 32c ^ 33a · 33b · 33c · 33d · 33e · 33f · 33g
    SP1:  -                 -     -     -                 -                                                         
    SP2:  -                 -     -     -                 -                                                         
    SP3:  -                 -     -     -                 -                                                         
    SP4:  -                 -     -     -                 -                                                         
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for MAN2A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAN2A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MAN2A2 Expression
    About this image


    See MAN2A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAN2A2

    SOURCE GeneReport for Unigene cluster: Hs.116459
        SABiosciences Expression via Pathway-Focused PCR Array including MAN2A2: 
              Glycosylation in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAN2A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAN2A2 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Man2a21 , 5 mannosidase 2, alpha 21, 5 86.51(n)1
    89.73(a)1
      7 (45.65 cM)5
    1404811  NM_172903.41  NP_766491.21 
     803490985 
    chicken
    (Gallus gallus)
    Aves MAN2A21 mannosidase, alpha, class 2A, member 2 77.74(n)
    78.99(a)
      415585  XM_001233607.2  XP_001233608.2 
    lizard
    (Anolis carolinensis)
    Reptilia MAN2A26
    Uncharacterized protein
    76(a)
    1 ↔ 1
    GL343759.1(77741-97693)
    zebrafish
    (Danio rerio)
    Actinopterygii man2a21 mannosidase, alpha, class 2A, member 2 67.8(n)
    68.82(a)
      100333987  XM_002666791.2  XP_002666837.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta alpha-Man-IIb3
    alpha-Man-II1
    alpha-mannosidase3
    alpha Mannosidase II1
    40(a)3
    52.19(n)1
    44.36(a)1
      89A53
    411261  NM_079567.21  NP_524291.21 
    worm
    (Caenorhabditis elegans)
    Secernentea aman-26
    aman-36
    Protein AMAN-3
    36(a)
    27(a)
    1 ↔ many
    possible ortholog
    V(11927652-11933325)
    I(5324511-5330212)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GMII1 alpha-mannosidase II 48.77(n)
    44.21(a)
      831347  NM_121499.2  NP_196999.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g02457001 hypothetical protein 50.05(n)
    43.86(a)
      4340636  NM_001063812.2  NP_001057277.2 


    ENSEMBL Gene Tree for MAN2A2 (if available)
    TreeFam Gene Tree for MAN2A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAN2A2 gene
    MAN2B12  MAN2B22  ENSG000002692422  ENSG000002695902  MAN2A12  
    2 SIMAP similar genes for MAN2A2 using alignment to 16 protein entries:     MA2A2_HUMAN (see all proteins):
    MAN2A1    MANB

    MAN2A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/682 SNPs in MAN2A2 are shown (see all 682)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1852773781,2
    --71169733(+) CTTGAA/GGGATT 1 -- us2k10--------
    rs1899902421,2
    --71169777(+) AGATAA/TTGTTA 1 -- us2k10--------
    rs1442607541,2
    --91445539(+) CACTCA/GCTGGC 1 -- us2k10--------
    rs1483008981,2
    --91445540(+) ACTCGC/TTGGCA 1 -- us2k10--------
    rs26777411,2
    C,F--91445794(+) CTCCTG/AAGGTT 1 -- us2k12Minor allele frequency- A:0.04WA 120
    rs1825985191,2
    C--91445949(+) CGGCTA/GTCCCC 1 -- us2k10--------
    rs714073441,2
    C,F--91445976(+) GGCCCG/TGCAGC 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1430569621,2
    --91446225(+) GCGCGC/TGCGGG 1 -- us2k10--------
    rs284466441,2
    C,F--91446316(+) GGGACA/TGGAGG 1 -- us2k11Minor allele frequency- T:0.36WA 118
    rs7342521,2
    C,F,A,H--91446472(-) GGCCAG/ATGTGG 1 -- us2k1 tfbs328Minor allele frequency- A:0.31NA EA MN NS WA CSA 2823

    HapMap Linkage Disequilibrium report for MAN2A2 (91445448 - 91465815 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MAN2A2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833089CNV Loss17160897
    nsv515661CNV Loss19592680
    nsv833090CNV Loss17160897


    Human Gene Mutation Database (HGMD): MAN2A2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MAN2A2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MAN2A2 for disorders           About MalaCards
    OMIM gene information: 600988    OMIM disorders: --


    MAN2A2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MAN2A2

    Export disorders for MAN2A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAN2A2 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with MAN2A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of cDNAs encoding human alpha- mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme. (PubMed id 8524845)1, 2, 3, 9 Misago M....Fukuda M.N. (1995)
    2. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)1, 4 Lesch K.P....Jacob C. (2008)
    3. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    4. HIV-1 gp120 N-linked glycosylation differs between pla sma and leukocyte compartments. (PubMed id 18215327)1 Ho Y.S....Saksena N.K. (2008)
    5. Glycosylation site-specific analysis of HIV envelope proteins (JR-FL and CON-S) reveals major differences in glycosylation site occupancy, glycoform profiles, and antigenic epitopes' accessibility. (PubMed id 18330979)1 Go E.P....Desaire H. (2008)
    6. Env length and N-linked glycosylation following transm ission of human immunodeficiency virus Type 1 subtype B viruses. (PubMed id 18314154)1 Liu Y....Mullins J.I. (2008)
    7. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
    8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4122 HGNC: 6825 AceView: MAN2A2 Ensembl:ENSG00000196547 euGenes: HUgn4122
    ECgene: MAN2A2 Kegg: 4122 H-InvDB: MAN2A2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAN2A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAN2A2 gene:
    Search GeneIP for patents involving MAN2A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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