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Aliases for MAN2A1 Gene

Aliases for MAN2A1 Gene

  • Mannosidase, Alpha, Class 2A, Member 1 2 3
  • MANA2 3 4 6
  • Mannosyl-Oligosaccharide 1,3-1,6-Alpha-Mannosidase 3 4
  • Golgi Integral Membrane Protein 7 2 3
  • Golgi Alpha-Mannosidase II 3 4
  • EC 3.2.1.114 4 64
  • AMan II 3 4
  • Mannosidase Alpha Class 2A Member 1 4
  • Mannosidase, Alpha Type II 3
  • Alpha-Mannosidase 2 3
  • EC 3.2.1 64
  • GOLIM7 3
  • Man II 4
  • MANII 3

External Ids for MAN2A1 Gene

Previous Symbols for MAN2A1 Gene

  • MANA2

Summaries for MAN2A1 Gene

Entrez Gene Summary for MAN2A1 Gene

  • This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013]

GeneCards Summary for MAN2A1 Gene

MAN2A1 (Mannosidase, Alpha, Class 2A, Member 1) is a Protein Coding gene. Diseases associated with MAN2A1 include systemic lupus erythematosus and mannosidosis. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include carbohydrate binding and mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity. An important paralog of this gene is MAN2B1.

UniProtKB/Swiss-Prot for MAN2A1 Gene

  • Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway

Tocris Summary for MAN2A1 Gene

  • Mannosidases are divided into two subtypes; I and II, (EC numbers 3.2.1.113 and 3.2.1.114 respectively) which display a wide expression pattern. Mannosidase I hydrolyzes (1,2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2 and mannosidase II hydrolyzes (1,3)- and (1,6)-linked alpha-D-mannose residues in Man5(GlcNAc)3. Both subtypes require a divalent cation cofactor. Mutations in mannosidases can cause mannosidosis (mannosidase I deficiency).

Gene Wiki entry for MAN2A1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAN2A1 Gene

Genomics for MAN2A1 Gene

Genomic Location for MAN2A1 Gene

Start:
109,689,366 bp from pter
End:
109,869,625 bp from pter
Size:
180,260 bases
Orientation:
Plus strand

Genomic View for MAN2A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAN2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAN2A1 Gene

Regulatory Elements for MAN2A1 Gene

Proteins for MAN2A1 Gene

  • Protein details for MAN2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16706-MA2A1_HUMAN
    Recommended name:
    Alpha-mannosidase 2
    Protein Accession:
    Q16706
    Secondary Accessions:
    • Q16767

    Protein attributes for MAN2A1 Gene

    Size:
    1144 amino acids
    Molecular mass:
    131141 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Homodimer; disulfide-linked.

neXtProt entry for MAN2A1 Gene

Proteomics data for MAN2A1 Gene at MOPED

Post-translational modifications for MAN2A1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn78, Asn93, Ser105, and Asn1125

Other Protein References for MAN2A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for MAN2A1 Gene

UniProtKB/Swiss-Prot:

MA2A1_HUMAN
Family:
  • Belongs to the glycosyl hydrolase 38 family.:
    • Q16706
genes like me logo Genes that share domains with MAN2A1: view

No data available for Gene Families for MAN2A1 Gene

Function for MAN2A1 Gene

Molecular function for MAN2A1 Gene

GENATLAS Biochemistry: Golgi alpha-mannosidase,class 2A,member 1,membrane type,involved in the processing of newly synthesized N-glycans mainly expressed in erythroid cells, hepatic tissue
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3)
UniProtKB/Swiss-Prot Function: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway

Enzyme Numbers (IUBMB) for MAN2A1 Gene

Gene Ontology (GO) - Molecular Function for MAN2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds --
GO:0004559 alpha-mannosidase activity --
GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MAN2A1: view
genes like me logo Genes that share phenotypes with MAN2A1: view

Animal Models for MAN2A1 Gene

MGI Knock Outs for MAN2A1:

miRNA for MAN2A1 Gene

miRTarBase miRNAs that target MAN2A1

No data available for Transcription Factor Targeting and HOMER Transcription for MAN2A1 Gene

Localization for MAN2A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAN2A1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAN2A1 Gene COMPARTMENTS Subcellular localization image for MAN2A1 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MAN2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus --
GO:0005801 cis-Golgi network IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MAN2A1: view

Pathways for MAN2A1 Gene

genes like me logo Genes that share pathways with MAN2A1: view

UniProtKB/Swiss-Prot Q16706-MA2A1_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for MAN2A1 Gene

Gene Ontology (GO) - Biological Process for MAN2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001889 liver development IEA --
GO:0005975 carbohydrate metabolic process --
GO:0006013 mannose metabolic process IEA --
GO:0006491 N-glycan processing IEA --
genes like me logo Genes that share ontologies with MAN2A1: view

Compounds for MAN2A1 Gene

(5) Tocris Compounds for MAN2A1 Gene

Compound Action Cas Number
1-Deoxymannojirimycin hydrochloride alpha-Mannosidase I inhibitor [73465-43-7]
1-Deoxynojirimycin Glucosidase I and II inhibitor [19130-96-2]
Kifunensine Inhibitor of class I alpha-mannosidases [109944-15-2]
Miglitol alpha-glucosidase inhibitor [72432-03-2]
OGT 2115 Antiangiogenic. Heparanase inhibitor [853929-59-6]

(2) HMDB Compounds for MAN2A1 Gene

Compound Synonyms Cas Number PubMed IDs
D-Mannose
  • DL-mannose
3458-28-4
Water
  • Dihydrogen oxide
7732-18-5

(5) Novoseek inferred chemical compound relationships for MAN2A1 Gene

Compound -log(P) Hits PubMed IDs
swainsonine 93.2 8
man5glcnac2 74.8 1
mannose 66.2 4
polysaccharide 51.2 3
asparagine 28.9 1
genes like me logo Genes that share compounds with MAN2A1: view

Transcripts for MAN2A1 Gene

Unigene Clusters for MAN2A1 Gene

Mannosidase, alpha, class 2A, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAN2A1 Gene

No ASD Table

Relevant External Links for MAN2A1 Gene

GeneLoc Exon Structure for
MAN2A1
ECgene alternative splicing isoforms for
MAN2A1

Expression for MAN2A1 Gene

mRNA expression in normal human tissues for MAN2A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAN2A1 Gene

SOURCE GeneReport for Unigene cluster for MAN2A1 Gene Hs.432822

genes like me logo Genes that share expressions with MAN2A1: view

Orthologs for MAN2A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAN2A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAN2A1 36
  • 99.68 (n)
  • 99.83 (a)
MAN2A1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAN2A1 36
  • 85.9 (n)
  • 82.95 (a)
MAN2A1 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAN2A1 36
  • 87.9 (n)
  • 84.17 (a)
MAN2A1 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Man2a1 36
  • 81.39 (n)
  • 81.01 (a)
Man2a1 16
Man2a1 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAN2A1 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAN2A1 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Man2a1 36
  • 80.61 (n)
  • 79.44 (a)
chicken
(Gallus gallus)
Aves MAN2A1 36
  • 73.69 (n)
  • 72.64 (a)
MAN2A1 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAN2A1 37
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia man2a1 36
  • 69.5 (n)
  • 69.09 (a)
Str.12619 36
zebrafish
(Danio rerio)
Actinopterygii man2a1 37
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta alpha-Man-II 37
  • 40 (a)
OneToMany
alpha-Man-II 38
  • 39 (a)
alpha-Man-IIb 38
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea aman-2 37
  • 37 (a)
ManyToMany
aman-3 37
  • 29 (a)
ManyToMany
F58H1.1 38
  • 36 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2151 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 45 (a)
OneToMany
Species with no ortholog for MAN2A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAN2A1 Gene

ENSEMBL:
Gene Tree for MAN2A1 (if available)
TreeFam:
Gene Tree for MAN2A1 (if available)

Paralogs for MAN2A1 Gene

Paralogs for MAN2A1 Gene

Selected SIMAP similar genes for MAN2A1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MAN2A1: view

Variants for MAN2A1 Gene

Sequence variations from dbSNP and Humsavar for MAN2A1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs2671 -- 109,868,553(+) TTTCT(C/T)TTTCA utr-variant-3-prime
rs3563 -- 109,868,538(+) GAAAT(A/G)AAAAC utr-variant-3-prime
rs248749 -- 109,694,447(+) caagc(C/T)attct intron-variant
rs248750 -- 109,746,528(+) CATAG(A/G)CATAT intron-variant
rs248751 -- 109,736,099(+) TATTA(C/T)GTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAN2A1 Gene

Variant ID Type Subtype PubMed ID
nsv462380 CNV Loss 19166990
esv267470 CNV Insertion 20981092
nsv327532 CNV Insertion 16902084
esv6990 CNV Gain 19470904
esv6208 CNV Gain 19470904
esv2540552 CNV Insertion 19546169
esv267440 CNV Insertion 20981092
esv273187 CNV Insertion 20981092
esv2656631 CNV Deletion 23128226

Relevant External Links for MAN2A1 Gene

HapMap Linkage Disequilibrium report
MAN2A1

Disorders for MAN2A1 Gene

(1) University of Copenhagen DISEASES for MAN2A1 Gene

(4) Novoseek inferred disease relationships for MAN2A1 Gene

Disease -log(P) Hits PubMed IDs
anemia dyserythropoietic congenital 88.3 3
autoimmune diseases 0 1
metastasis 0 1
cancer 0 2

Relevant External Links for MAN2A1

Genetic Association Database (GAD)
MAN2A1
Human Genome Epidemiology (HuGE) Navigator
MAN2A1
genes like me logo Genes that share disorders with MAN2A1: view

No data available for UniProtKB/Swiss-Prot for MAN2A1 Gene

Publications for MAN2A1 Gene

  1. Molecular cloning and expression of cDNAs encoding human alpha- mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme. (PMID: 8524845) Misago M. … Fukuda M.N. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 4 23
  2. Isolation, characterization, and expression of cDNAs encoding murine alpha-mannosidase II, a Golgi enzyme that controls conversion of high mannose to complex N-glycans. (PMID: 1757461) Moremen K.W. … Robbins P.W. (J. Cell Biol. 1991) 2 3 23
  3. The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins. (PMID: 15004235) Oka T. … Krieger M. (Mol. Biol. Cell 2004) 2 3
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4
  5. Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus. (PMID: 18174230) Miyagawa H. … Horiuchi T. (Rheumatology (Oxford) 2008) 3 49

Products for MAN2A1 Gene

Sources for MAN2A1 Gene

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