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Aliases for MAN1C1 Gene

Aliases for MAN1C1 Gene

  • Mannosidase Alpha Class 1C Member 1 2 3 4
  • Mannosidase, Alpha, Class 1C, Member 1 2 3 5
  • Processing Alpha-1,2-Mannosidase IC 3 4
  • EC 3.2.1.113 4 63
  • MAN1A3 3 4
  • MAN1C 3 4
  • HMIC 3 4
  • 1,2-Alpha-Mannosidase IC 3
  • Alpha-1,2-Mannosidase IC 4
  • Pp6318 3

External Ids for MAN1C1 Gene

Previous GeneCards Identifiers for MAN1C1 Gene

  • GC01P025424
  • GC01P024964
  • GC01P025177
  • GC01P025548
  • GC01P025816
  • GC01P025943
  • GC01P024197

Summaries for MAN1C1 Gene

GeneCards Summary for MAN1C1 Gene

MAN1C1 (Mannosidase Alpha Class 1C Member 1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include calcium ion binding and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. An important paralog of this gene is MAN1B1.

UniProtKB/Swiss-Prot for MAN1C1 Gene

  • Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc.

Tocris Summary for MAN1C1 Gene

  • Glycosylases are a group of enzymes that includes glucosidases, mannosidases and heparanases. There are two glucosidase subtypes, both found in the gut. They hydrolyze terminal (1,4)alpha-glucosidic linkages and (1,6)beta-glucosidic linkages, liberating alpha-glucose and beta-glucose.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAN1C1 Gene

Genomics for MAN1C1 Gene

Regulatory Elements for MAN1C1 Gene

Enhancers for MAN1C1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAN1C1 on UCSC Golden Path with GeneCards custom track

Promoters for MAN1C1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAN1C1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAN1C1 Gene

Chromosome:
1
Start:
25,617,468 bp from pter
End:
25,786,207 bp from pter
Size:
168,740 bases
Orientation:
Plus strand

Genomic View for MAN1C1 Gene

Genes around MAN1C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAN1C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAN1C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAN1C1 Gene

Proteins for MAN1C1 Gene

  • Protein details for MAN1C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR34-MA1C1_HUMAN
    Recommended name:
    Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC
    Protein Accession:
    Q9NR34
    Secondary Accessions:
    • A6NNE2
    • B2RNP2
    • Q9Y545

    Protein attributes for MAN1C1 Gene

    Size:
    630 amino acids
    Molecular mass:
    70911 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for MAN1C1 Gene

Proteomics data for MAN1C1 Gene at MOPED

Selected DME Specific Peptides for MAN1C1 Gene

Post-translational modifications for MAN1C1 Gene

  • Glycosylation at Ser 132, Asn 250, and Asn 618
  • Modification sites at PhosphoSitePlus

Other Protein References for MAN1C1 Gene

Domains & Families for MAN1C1 Gene

Gene Families for MAN1C1 Gene

Protein Domains for MAN1C1 Gene

Suggested Antigen Peptide Sequences for MAN1C1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NR34

UniProtKB/Swiss-Prot:

MA1C1_HUMAN :
  • Belongs to the glycosyl hydrolase 47 family.
Family:
  • Belongs to the glycosyl hydrolase 47 family.
genes like me logo Genes that share domains with MAN1C1: view

Function for MAN1C1 Gene

Molecular function for MAN1C1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by both 1-deoxymannojirimycin and kifunensine.
UniProtKB/Swiss-Prot Function:
Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc.

Enzyme Numbers (IUBMB) for MAN1C1 Gene

Gene Ontology (GO) - Molecular Function for MAN1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA,TAS 10915796
genes like me logo Genes that share ontologies with MAN1C1: view
genes like me logo Genes that share phenotypes with MAN1C1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MAN1C1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MAN1C1 Gene

Localization for MAN1C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAN1C1 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAN1C1 Gene COMPARTMENTS Subcellular localization image for MAN1C1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endoplasmic reticulum 3
cytosol 1
lysosome 1
mitochondrion 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MAN1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA --
genes like me logo Genes that share ontologies with MAN1C1: view

Pathways & Interactions for MAN1C1 Gene

genes like me logo Genes that share pathways with MAN1C1: view

UniProtKB/Swiss-Prot Q9NR34-MA1C1_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for MAN1C1 Gene

Gene Ontology (GO) - Biological Process for MAN1C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with MAN1C1: view

No data available for SIGNOR curated interactions for MAN1C1 Gene

Drugs & Compounds for MAN1C1 Gene

(3) Drugs for MAN1C1 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acarbose Approved, Investigational Pharma Alpha-glucosidase inhibitor, Glucosidase alpha inhibitor (intestinal) 81
1-Deoxynojirimycin Experimental Pharma Glucosidase I and II inhibitor 0
calcium Nutra 0

(5) Additional Compounds for MAN1C1 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Mannose
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
3458-28-4
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
1-Deoxymannojirimycin hydrochloride
73465-43-7
castanospermine
79831-76-8
OGT 2115
853929-59-6

(5) Tocris Compounds for MAN1C1 Gene

Compound Action Cas Number
1-Deoxymannojirimycin hydrochloride alpha-Mannosidase I inhibitor 73465-43-7
1-Deoxynojirimycin Glucosidase I and II inhibitor 19130-96-2
Acarbose Glucosidase alpha inhibitor (intestinal) 56180-94-0
Castanospermine Glucosidases alpha and beta inhibitor 79831-76-8
OGT 2115 Antiangiogenic. Heparanase inhibitor 853929-59-6
genes like me logo Genes that share compounds with MAN1C1: view

Transcripts for MAN1C1 Gene

Unigene Clusters for MAN1C1 Gene

Mannosidase, alpha, class 1C, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAN1C1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - - -
SP2: - - - - - -
SP3:
SP4: -
SP5: -
SP6:

Relevant External Links for MAN1C1 Gene

GeneLoc Exon Structure for
MAN1C1
ECgene alternative splicing isoforms for
MAN1C1

Expression for MAN1C1 Gene

mRNA expression in normal human tissues for MAN1C1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAN1C1 Gene

This gene is overexpressed in Uterus (15.2), Cardia (14.7), Placenta (11.3), Esophagus (7.2), and Colon (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAN1C1 Gene



SOURCE GeneReport for Unigene cluster for MAN1C1 Gene Hs.197043

mRNA Expression by UniProt/SwissProt for MAN1C1 Gene

Q9NR34-MA1C1_HUMAN
Tissue specificity: Expressed in most tissues with the exception of lung, muscle and pancreas. Highly expressed in placenta.
genes like me logo Genes that share expression patterns with MAN1C1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for MAN1C1 Gene

Orthologs for MAN1C1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAN1C1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAN1C1 35
  • 89.7 (n)
  • 90.13 (a)
MAN1C1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAN1C1 35
  • 90.92 (n)
  • 90.91 (a)
MAN1C1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Man1c1 35
  • 85.36 (n)
  • 89.79 (a)
Man1c1 16
Man1c1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAN1C1 35
  • 99.47 (n)
  • 99.64 (a)
MAN1C1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Man1c1 35
  • 85.65 (n)
  • 89.44 (a)
oppossum
(Monodelphis domestica)
Mammalia MAN1C1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAN1C1 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAN1C1 35
  • 73.94 (n)
  • 79.06 (a)
MAN1C1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAN1C1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia man1c1 35
  • 60.87 (n)
  • 63.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta alpha-Man-I 36
  • 38 (a)
ManyToMany
CG31202 36
  • 39 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea mans-1 36
  • 44 (a)
ManyToMany
mans-2 36
  • 38 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MNS1 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToMany
Species with no ortholog for MAN1C1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MAN1C1 Gene

ENSEMBL:
Gene Tree for MAN1C1 (if available)
TreeFam:
Gene Tree for MAN1C1 (if available)

Paralogs for MAN1C1 Gene

Paralogs for MAN1C1 Gene

(6) SIMAP similar genes for MAN1C1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MAN1C1: view

Variants for MAN1C1 Gene

Sequence variations from dbSNP and Humsavar for MAN1C1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs807255 -- 25,758,231(-) CACCC(A/G)GTTGC intron-variant
rs807256 -- 25,757,610(-) GGCGA(A/T)GCCTC intron-variant
rs807257 -- 25,757,323(-) TGAGC(A/G)ACTGG intron-variant
rs807258 -- 25,757,044(-) ACAGA(C/T)GAAGG intron-variant
rs807259 -- 25,756,706(-) TTCAA(A/T)CAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAN1C1 Gene

Variant ID Type Subtype PubMed ID
nsv834491 CNV Loss 17160897
nsv871186 CNV Gain 21882294
nsv819900 CNV Gain 19587683
esv2745619 CNV Deletion 23290073
esv2116011 CNV Deletion 18987734
esv2671844 CNV Deletion 23128226
esv2745630 CNV Deletion 23290073
nsv460884 CNV Loss 19166990

Variation tolerance for MAN1C1 Gene

Residual Variation Intolerance Score: 14.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.17; 51.84% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MAN1C1 Gene

Disorders for MAN1C1 Gene

Relevant External Links for MAN1C1

Genetic Association Database (GAD)
MAN1C1
Human Genome Epidemiology (HuGE) Navigator
MAN1C1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAN1C1

No disorders were found for MAN1C1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAN1C1 Gene

Publications for MAN1C1 Gene

  1. Characterization of a cDNA encoding a novel human Golgi alpha 1,2- mannosidase involved in N-glycan biosynthesis. (PMID: 10915796) Tremblay L.O. … Herscovics A. (J. Biol. Chem. 2000) 2 3 4 67
  2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Stimulation of ERAD of misfolded null Hong Kong alpha1-antitrypsin by Golgi alpha1,2-mannosidases. (PMID: 17727818) Hosokawa N. … Herscovics A. (Biochem. Biophys. Res. Commun. 2007) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for MAN1C1 Gene

Sources for MAN1C1 Gene

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