Aliases for MAN1C1 Gene
External Ids for MAN1C1 Gene
Previous GeneCards Identifiers for MAN1C1 Gene
GeneCards Summary for MAN1C1 Gene
MAN1C1 (Mannosidase, Alpha, Class 1C, Member 1) is a Protein Coding gene. Diseases associated with MAN1C1 include mannosidosis. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include calcium ion binding and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. An important paralog of this gene is MAN1B1.
UniProtKB/Swiss-Prot for MAN1C1 Gene
Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc
Mannosidases are divided into two subtypes; I and II, (EC numbers 220.127.116.11 and 18.104.22.168 respectively) which display a wide expression pattern. Mannosidase I hydrolyzes (1,2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2 and mannosidase II hydrolyzes (1,3)- and (1,6)-linked alpha-D-mannose residues in Man5(GlcNAc)3. Both subtypes require a divalent cation cofactor. Mutations in mannosidases can cause mannosidosis (mannosidase I deficiency).