Aliases for MAN1A2 Gene
External Ids for MAN1A2 Gene
Previous GeneCards Identifiers for MAN1A2 Gene
Alpha-mannosidases function at different stages of N-glycan maturation in mammalian cells. See MAN2A1 (MIM 154582) for general information.[supplied by OMIM, Mar 2008]
GeneCards Summary for MAN1A2 Gene
MAN1A2 (Mannosidase, Alpha, Class 1A, Member 2) is a Protein Coding gene. Diseases associated with MAN1A2 include mannosidosis. Among its related pathways are Metabolism and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include calcium ion binding and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. An important paralog of this gene is MAN1B1.
UniProtKB/Swiss-Prot for MAN1A2 Gene
Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)
Mannosidases are divided into two subtypes; I and II, (EC numbers 18.104.22.168 and 22.214.171.124 respectively) which display a wide expression pattern. Mannosidase I hydrolyzes (1,2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2 and mannosidase II hydrolyzes (1,3)- and (1,6)-linked alpha-D-mannose residues in Man5(GlcNAc)3. Both subtypes require a divalent cation cofactor. Mutations in mannosidases can cause mannosidosis (mannosidase I deficiency).