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Aliases for MAN1A2 Gene

Aliases for MAN1A2 Gene

  • Mannosidase, Alpha, Class 1A, Member 2 2 3
  • Processing Alpha-1,2-Mannosidase IB 3 4
  • Alpha-1,2-Mannosidase IB 3 4
  • EC 4 64
  • MAN1B 3 4
  • Mannosyl-Oligosaccharide 1,2-Alpha-Mannosidase IB 3
  • Mannosidase Alpha Class 1A Member 2 4
  • Alpha1,2-Mannosidase 3

External Ids for MAN1A2 Gene

Summaries for MAN1A2 Gene

Entrez Gene Summary for MAN1A2 Gene

  • Alpha-mannosidases function at different stages of N-glycan maturation in mammalian cells. See MAN2A1 (MIM 154582) for general information.[supplied by OMIM, Mar 2008]

GeneCards Summary for MAN1A2 Gene

MAN1A2 (Mannosidase, Alpha, Class 1A, Member 2) is a Protein Coding gene. Diseases associated with MAN1A2 include mannosidosis. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include calcium ion binding and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. An important paralog of this gene is MAN1B1.

UniProtKB/Swiss-Prot for MAN1A2 Gene

  • Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)

Tocris Summary for MAN1A2 Gene

  • Mannosidases are divided into two subtypes; I and II, (EC numbers and respectively) which display a wide expression pattern. Mannosidase I hydrolyzes (1,2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man9(GlcNAc)2 and mannosidase II hydrolyzes (1,3)- and (1,6)-linked alpha-D-mannose residues in Man5(GlcNAc)3. Both subtypes require a divalent cation cofactor. Mutations in mannosidases can cause mannosidosis (mannosidase I deficiency).

Gene Wiki entry for MAN1A2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAN1A2 Gene

Genomics for MAN1A2 Gene

Genomic Location for MAN1A2 Gene

117,367,393 bp from pter
117,528,872 bp from pter
161,480 bases
Plus strand

Genomic View for MAN1A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAN1A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAN1A2 Gene

Regulatory Elements for MAN1A2 Gene

Proteins for MAN1A2 Gene

  • Protein details for MAN1A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
    Protein Accession:
    Secondary Accessions:
    • Q9H510

    Protein attributes for MAN1A2 Gene

    641 amino acids
    Molecular mass:
    73004 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for MAN1A2 Gene

Proteomics data for MAN1A2 Gene at MOPED

Post-translational modifications for MAN1A2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn631

Other Protein References for MAN1A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for MAN1A2 Gene

Protein Domains for MAN1A2 Gene


  • Belongs to the glycosyl hydrolase 47 family.:
    • O60476
genes like me logo Genes that share domains with MAN1A2: view

No data available for Gene Families for MAN1A2 Gene

Function for MAN1A2 Gene

Molecular function for MAN1A2 Gene

GENATLAS Biochemistry: alpha-mannosidase,class 1A,member 2,membrane type,expressed in brain placenta and lymphocytes,involved in processing of Asp-linked (N) glycans
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by both 1-deoxymannojirimycin and kifunensine
UniProtKB/Swiss-Prot Function: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)

Enzyme Numbers (IUBMB) for MAN1A2 Gene

Gene Ontology (GO) - Molecular Function for MAN1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with MAN1A2: view
genes like me logo Genes that share phenotypes with MAN1A2: view

Animal Models for MAN1A2 Gene

MGI Knock Outs for MAN1A2:

miRNA for MAN1A2 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for MAN1A2 Gene

Localization for MAN1A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAN1A2 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for MAN1A2 Gene COMPARTMENTS Subcellular localization image for MAN1A2 gene
Compartment Confidence
golgi apparatus 5
nucleus 4
cytosol 2
mitochondrion 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MAN1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005730 nucleolus --
GO:0005794 Golgi apparatus IDA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MAN1A2: view

Pathways for MAN1A2 Gene

genes like me logo Genes that share pathways with MAN1A2: view

UniProtKB/Swiss-Prot O60476-MA1A2_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for MAN1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006491 N-glycan processing TAS 9592125
GO:0007585 respiratory gaseous exchange IEA --
GO:0008152 metabolic process --
GO:0009100 glycoprotein metabolic process --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
genes like me logo Genes that share ontologies with MAN1A2: view

Compounds for MAN1A2 Gene

(5) Tocris Compounds for MAN1A2 Gene

Compound Action Cas Number
1-Deoxymannojirimycin hydrochloride alpha-Mannosidase I inhibitor [73465-43-7]
1-Deoxynojirimycin Glucosidase I and II inhibitor [19130-96-2]
Kifunensine Inhibitor of class I alpha-mannosidases [109944-15-2]
Miglitol alpha-glucosidase inhibitor [72432-03-2]
OGT 2115 Antiangiogenic. Heparanase inhibitor [853929-59-6]

(3) HMDB Compounds for MAN1A2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • DL-mannose
  • Dihydrogen oxide

(5) Novoseek inferred chemical compound relationships for MAN1A2 Gene

Compound -log(P) Hits PubMed IDs
man5glcnac2 90.6 2
1-deoxynojirimycin 88.7 3
man9(glcnac)2 85 1
mannose 71.4 1
calcium 8.67 2
genes like me logo Genes that share compounds with MAN1A2: view

Transcripts for MAN1A2 Gene

Unigene Clusters for MAN1A2 Gene

Mannosidase, alpha, class 1A, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAN1A2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b
SP1: -
SP3: -
SP4: - -

Relevant External Links for MAN1A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAN1A2 Gene

mRNA expression in normal human tissues for MAN1A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAN1A2 Gene

SOURCE GeneReport for Unigene cluster for MAN1A2 Gene Hs.435938

mRNA Expression by UniProt/SwissProt for MAN1A2 Gene

Tissue specificity: Highest levels of expression in placenta and testis
genes like me logo Genes that share expressions with MAN1A2: view

Orthologs for MAN1A2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAN1A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAN1A2 36
  • 99.58 (n)
  • 99.22 (a)
MAN1A2 37
  • 99 (a)
(Bos Taurus)
Mammalia MAN1A2 36
  • 93.34 (n)
  • 95.63 (a)
MAN1A2 37
  • 95 (a)
(Canis familiaris)
Mammalia MAN1A2 36
  • 93.4 (n)
  • 97.04 (a)
MAN1A2 37
  • 97 (a)
(Mus musculus)
Mammalia Man1a2 36
  • 89.6 (n)
  • 94.54 (a)
Man1a2 16
Man1a2 37
  • 95 (a)
(Monodelphis domestica)
Mammalia MAN1A2 37
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia MAN1A2 37
  • 90 (a)
(Rattus norvegicus)
Mammalia Man1a2 36
  • 89.5 (n)
  • 95.01 (a)
(Gallus gallus)
Aves MAN1A2 36
  • 80.86 (n)
  • 89.24 (a)
MAN1A2 37
  • 89 (a)
(Anolis carolinensis)
Reptilia MAN1A2 37
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia man1a2 36
  • 72.65 (n)
  • 84.09 (a)
(Danio rerio)
Actinopterygii Dr.18766 36
MAN1A2 37
  • 83 (a)
wu:fj20e02 36
  • 72.65 (n)
  • 83.31 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000558 36
  • 56.46 (n)
  • 59.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta alpha-Man-I 36
  • 53.32 (n)
  • 51.35 (a)
alpha-Man-I 37
  • 43 (a)
CG31202 37
  • 38 (a)
alpha-Man-I 38
  • 58 (a)
(Caenorhabditis elegans)
Secernentea C52E4.5 36
  • 52.21 (n)
  • 46.17 (a)
mans-1 37
  • 45 (a)
mans-2 37
  • 40 (a)
D2030.1 38
  • 41 (a)
C52E4.5 38
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MNS1 37
  • 33 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02235 36
  • 48.31 (n)
  • 40.97 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1038 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
Species with no ortholog for MAN1A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAN1A2 Gene

Gene Tree for MAN1A2 (if available)
Gene Tree for MAN1A2 (if available)

Paralogs for MAN1A2 Gene

Paralogs for MAN1A2 Gene

Selected SIMAP similar genes for MAN1A2 Gene using alignment to 4 proteins: Pseudogenes for MAN1A2 Gene

genes like me logo Genes that share paralogs with MAN1A2: view

Variants for MAN1A2 Gene

Sequence variations from dbSNP and Humsavar for MAN1A2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9557 -- 117,526,312(+) TGTAT(A/G)AGAGT utr-variant-3-prime
rs9681 -- 117,528,716(-) TTTAA(A/G)AAAAA utr-variant-3-prime
rs9951 -- 117,523,737(-) CAACA(C/G)TAGAC utr-variant-3-prime
rs10884 -- 117,526,441(+) TTACT(A/G)TATAA utr-variant-3-prime
rs884748 -- 117,408,225(+) GGGGC(A/G)CCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAN1A2 Gene

Variant ID Type Subtype PubMed ID
esv1005427 CNV Deletion 20482838
nsv872166 CNV Loss 21882294
esv2224574 CNV Deletion 18987734
nsv831170 CNV Gain 17160897
nsv519780 CNV Gain 19592680
nsv819679 CNV Loss 19587683
nsv506956 CNV Insertion 20534489
esv2661362 CNV Deletion 23128226

Relevant External Links for MAN1A2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for MAN1A2 Gene

(1) MalaCards Diseases for MAN1A2 Gene

Search for MAN1A2 Gene in MalaCards »

Relevant External Links for MAN1A2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MAN1A2: view

No data available for UniProtKB/Swiss-Prot for MAN1A2 Gene

Publications for MAN1A2 Gene

  1. Molecular cloning, chromosomal mapping and tissue-specific expression of a novel human alpha-1,2-mannosidase gene involved in N-glycan maturation. (PMID: 9592125) Tremblay L.O. … Herscovics A. (Glycobiology 1998) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Screening for replication of genome-wide SNP associations in sporadic ALS. (PMID: 18987618) Cronin S. … Hardiman O. (Eur. J. Hum. Genet. 2009) 3 49
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for MAN1A2 Gene

Sources for MAN1A2 Gene

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