Aliases for MAN1A2 Gene
External Ids for MAN1A2 Gene
Previous GeneCards Identifiers for MAN1A2 Gene
Alpha-mannosidases function at different stages of N-glycan maturation in mammalian cells. See MAN2A1 (MIM 154582) for general information.[supplied by OMIM, Mar 2008]
GeneCards Summary for MAN1A2 Gene
MAN1A2 (Mannosidase Alpha Class 1A Member 2) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and Golgi-to-ER retrograde transport. GO annotations related to this gene include calcium ion binding and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. An important paralog of this gene is MAN1A1.
UniProtKB/Swiss-Prot for MAN1A2 Gene
Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
Glycosylases are a group of enzymes that includes glucosidases, mannosidases and heparanases. There are two glucosidase subtypes, both found in the gut. They hydrolyze terminal (1,4)alpha-glucosidic linkages and (1,6)beta-glucosidic linkages, liberating alpha-glucose and beta-glucose.