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Aliases for MAN1A2 Gene

Aliases for MAN1A2 Gene

  • Mannosidase, Alpha, Class 1A, Member 2 2 3
  • Processing Alpha-1,2-Mannosidase IB 3 4
  • Alpha-1,2-Mannosidase IB 3 4
  • EC 3.2.1.113 4 63
  • MAN1B 3 4
  • Mannosidase Alpha Class 1A Member 2 4
  • Alpha1,2-Mannosidase 3

External Ids for MAN1A2 Gene

Previous GeneCards Identifiers for MAN1A2 Gene

  • GC01P118369
  • GC01P116748
  • GC01P117057
  • GC01P117256
  • GC01P117623
  • GC01P117711
  • GC01P117910
  • GC01P115766

Summaries for MAN1A2 Gene

Entrez Gene Summary for MAN1A2 Gene

  • Alpha-mannosidases function at different stages of N-glycan maturation in mammalian cells. See MAN2A1 (MIM 154582) for general information.[supplied by OMIM, Mar 2008]

GeneCards Summary for MAN1A2 Gene

MAN1A2 (Mannosidase, Alpha, Class 1A, Member 2) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include calcium ion binding and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. An important paralog of this gene is MAN1B1.

UniProtKB/Swiss-Prot for MAN1A2 Gene

  • Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)

Tocris Summary for MAN1A2 Gene

  • Glycosylases are a group of enzymes that includes glucosidases, mannosidases and heparanases. There are two glucosidase subtypes, both found in the gut. They hydrolyze terminal (1,4)alpha-glucosidic linkages and (1,6)beta-glucosidic linkages, liberating alpha-glucose and beta-glucose.

Gene Wiki entry for MAN1A2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAN1A2 Gene

Genomics for MAN1A2 Gene

Regulatory Elements for MAN1A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAN1A2 Gene

Chromosome:
1
Start:
117,367,393 bp from pter
End:
117,528,872 bp from pter
Size:
161,480 bases
Orientation:
Plus strand

Genomic View for MAN1A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAN1A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAN1A2 Gene

Proteins for MAN1A2 Gene

  • Protein details for MAN1A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60476-MA1A2_HUMAN
    Recommended name:
    Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
    Protein Accession:
    O60476
    Secondary Accessions:
    • Q9H510

    Protein attributes for MAN1A2 Gene

    Size:
    641 amino acids
    Molecular mass:
    73004 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for MAN1A2 Gene

Proteomics data for MAN1A2 Gene at MOPED

Post-translational modifications for MAN1A2 Gene

  • Glycosylation at Asn 631
  • Modification sites at PhosphoSitePlus

Other Protein References for MAN1A2 Gene

Domains & Families for MAN1A2 Gene

Gene Families for MAN1A2 Gene

Protein Domains for MAN1A2 Gene

Graphical View of Domain Structure for InterPro Entry

O60476

UniProtKB/Swiss-Prot:

MA1A2_HUMAN :
  • Belongs to the glycosyl hydrolase 47 family.
Family:
  • Belongs to the glycosyl hydrolase 47 family.
genes like me logo Genes that share domains with MAN1A2: view

Function for MAN1A2 Gene

Molecular function for MAN1A2 Gene

GENATLAS Biochemistry:
alpha-mannosidase,class 1A,member 2,membrane type,expressed in brain placenta and lymphocytes,involved in processing of Asp-linked (N) glycans
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by both 1-deoxymannojirimycin and kifunensine
UniProtKB/Swiss-Prot Function:
Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)

Enzyme Numbers (IUBMB) for MAN1A2 Gene

Gene Ontology (GO) - Molecular Function for MAN1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with MAN1A2: view
genes like me logo Genes that share phenotypes with MAN1A2: view

Animal Models for MAN1A2 Gene

MGI Knock Outs for MAN1A2:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAN1A2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for MAN1A2 Gene

Localization for MAN1A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAN1A2 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAN1A2 Gene COMPARTMENTS Subcellular localization image for MAN1A2 gene
Compartment Confidence
extracellular 5
golgi apparatus 5

Gene Ontology (GO) - Cellular Components for MAN1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005783 endoplasmic reticulum IBA --
GO:0005794 Golgi apparatus IDA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MAN1A2: view

Pathways & Interactions for MAN1A2 Gene

genes like me logo Genes that share pathways with MAN1A2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot O60476-MA1A2_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for MAN1A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006491 N-glycan processing TAS 9592125
GO:0007585 respiratory gaseous exchange IEA --
GO:0008152 metabolic process --
GO:0009100 glycoprotein metabolic process --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
genes like me logo Genes that share ontologies with MAN1A2: view

No data available for SIGNOR curated interactions for MAN1A2 Gene

Drugs & Compounds for MAN1A2 Gene

(2) Drugs for MAN1A2 Gene - From: NovoSeek, Tocris, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1-Deoxynojirimycin Experimental Pharma Glucosidase I and II inhibitor 0
Calcium Nutra 0

(9) Additional Compounds for MAN1A2 Gene - From: HMDB, Tocris, and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Mannose
  • (+)-mannose
  • (+-)-mannose
  • Carubinose
  • D(+)-Mannose
  • D-Mannopyranose
3458-28-4
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
1-Deoxymannojirimycin hydrochloride
73465-43-7
castanospermine
79831-76-8
Miglustat hydrochloride
210110-90-0
genes like me logo Genes that share compounds with MAN1A2: view

Transcripts for MAN1A2 Gene

Unigene Clusters for MAN1A2 Gene

Mannosidase, alpha, class 1A, member 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAN1A2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAN1A2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b
SP1: -
SP2:
SP3: -
SP4: - -

Relevant External Links for MAN1A2 Gene

GeneLoc Exon Structure for
MAN1A2
ECgene alternative splicing isoforms for
MAN1A2

Expression for MAN1A2 Gene

mRNA expression in normal human tissues for MAN1A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MAN1A2 Gene

This gene is overexpressed in Placenta (21.9), Stomach (9.1), and Lymph node (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAN1A2 Gene



SOURCE GeneReport for Unigene cluster for MAN1A2 Gene Hs.435938

mRNA Expression by UniProt/SwissProt for MAN1A2 Gene

O60476-MA1A2_HUMAN
Tissue specificity: Highest levels of expression in placenta and testis
genes like me logo Genes that share expression patterns with MAN1A2: view

Protein tissue co-expression partners for MAN1A2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MAN1A2 Gene

Orthologs for MAN1A2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAN1A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAN1A2 35
  • 93.34 (n)
  • 95.63 (a)
MAN1A2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAN1A2 35
  • 93.4 (n)
  • 97.04 (a)
MAN1A2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Man1a2 35
  • 89.6 (n)
  • 94.54 (a)
Man1a2 16
Man1a2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAN1A2 35
  • 99.58 (n)
  • 99.22 (a)
MAN1A2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Man1a2 35
  • 89.5 (n)
  • 95.01 (a)
oppossum
(Monodelphis domestica)
Mammalia MAN1A2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAN1A2 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAN1A2 35
  • 80.86 (n)
  • 89.24 (a)
MAN1A2 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAN1A2 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia man1a2 35
  • 72.65 (n)
  • 84.09 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.18766 35
wu:fj20e02 35
  • 72.65 (n)
  • 83.31 (a)
MAN1A2 36
  • 83 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta alpha-Man-I 37
  • 58 (a)
alpha-Man-I 35
  • 53.32 (n)
  • 51.35 (a)
alpha-Man-I 36
  • 43 (a)
ManyToMany
CG31202 36
  • 38 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000558 35
  • 56.46 (n)
  • 59.09 (a)
worm
(Caenorhabditis elegans)
Secernentea C52E4.5 37
  • 46 (a)
D2030.1 37
  • 41 (a)
C52E4.5 35
  • 52.21 (n)
  • 46.17 (a)
mans-1 36
  • 45 (a)
ManyToMany
mans-2 36
  • 40 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MNS1 36
  • 33 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1038 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02235 35
  • 48.31 (n)
  • 40.97 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for MAN1A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAN1A2 Gene

ENSEMBL:
Gene Tree for MAN1A2 (if available)
TreeFam:
Gene Tree for MAN1A2 (if available)

Paralogs for MAN1A2 Gene

Paralogs for MAN1A2 Gene

(6) SIMAP similar genes for MAN1A2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for MAN1A2 Gene

genes like me logo Genes that share paralogs with MAN1A2: view

Variants for MAN1A2 Gene

Sequence variations from dbSNP and Humsavar for MAN1A2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9557 -- 117,526,312(+) TGTAT(A/G)AGAGT utr-variant-3-prime
rs9681 -- 117,528,716(-) TTTAA(A/G)AAAAA utr-variant-3-prime
rs9951 -- 117,523,737(-) CAACA(C/G)TAGAC utr-variant-3-prime
rs10884 -- 117,526,441(+) TTACT(A/G)TATAA utr-variant-3-prime
rs884748 -- 117,408,225(+) GGGGC(A/G)CCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAN1A2 Gene

Variant ID Type Subtype PubMed ID
esv1005427 CNV Deletion 20482838
nsv872166 CNV Loss 21882294
esv2224574 CNV Deletion 18987734
nsv831170 CNV Gain 17160897
nsv519780 CNV Gain 19592680
nsv819679 CNV Loss 19587683
nsv506956 CNV Insertion 20534489
esv2661362 CNV Deletion 23128226

Variation tolerance for MAN1A2 Gene

Residual Variation Intolerance Score: 17.22% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 31.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAN1A2 Gene

HapMap Linkage Disequilibrium report
MAN1A2
Human Gene Mutation Database (HGMD)
MAN1A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAN1A2 Gene

Disorders for MAN1A2 Gene

Relevant External Links for MAN1A2

Genetic Association Database (GAD)
MAN1A2
Human Genome Epidemiology (HuGE) Navigator
MAN1A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAN1A2
genes like me logo Genes that share disorders with MAN1A2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAN1A2 Gene

Publications for MAN1A2 Gene

  1. Molecular cloning, chromosomal mapping and tissue-specific expression of a novel human alpha-1,2-mannosidase gene involved in N-glycan maturation. (PMID: 9592125) Tremblay L.O. … Herscovics A. (Glycobiology 1998) 2 23 67
  2. N- and O-linked oligosaccharides completely lack galactose residues in the gms1och1 mutant of Schizosaccharomyces pombe. (PMID: 19844703) Ohashi T. … Takegawa K. (Appl. Microbiol. Biotechnol. 2010) 23 67
  3. Heterologous expression and biochemical characterization of an alpha1,2-mannosidase encoded by the Candida albicans MNS1 gene. (PMID: 19057825) Mora-Montes H.M. … Flores-CarreA^n A. (Mem. Inst. Oswaldo Cruz 2008) 23 67
  4. Endoplasmic reticulum alpha-glycosidases of Candida albicans are required for N glycosylation, cell wall integrity, and normal host-fungus interaction. (PMID: 17933909) Mora-Montes H.M. … Gow N.A. (Eukaryotic Cell 2007) 23 67
  5. EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation. (PMID: 16987498) Olivari S. … Molinari M. (Biochem. Biophys. Res. Commun. 2006) 23 67

Products for MAN1A2 Gene

Sources for MAN1A2 Gene

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