Aliases for MAN1A1 Gene
External Ids for MAN1A1 Gene
Previous GeneCards Identifiers for MAN1A1 Gene
This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. [provided by RefSeq, Jul 2012]
GeneCards Summary for MAN1A1 Gene
MAN1A1 (Mannosidase, Alpha, Class 1A, Member 1) is a Protein Coding gene. Among its related pathways are Metabolism and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include calcium ion binding and mannosidase activity. An important paralog of this gene is MAN1B1.
UniProtKB/Swiss-Prot for MAN1A1 Gene
Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)