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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAN1A1 Gene

protein-coding   GIFtS: 61
GCID: GC06M119540

mannosidase, alpha, class 1A, member 1
 Explore 2 diseases affiliated with
MAN1A1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MAN1A1    

Aliases
for MAN1A1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mannosidase, Alpha, Class 1A, Member 11 2     MAN92
Alpha-1,2-Mannosidase IA2 3     Man(9)-Alpha-Mannosidase1
Processing Alpha-1,2-Mannosidase IA2 3     Mannosyl-Oligosaccharide 1,2-Alpha-Mannosidase IA2
Man9-Mannosidase1     Man(9)-Alpha-Mannosidase1
EC 3.2.1.1133 8     Mannosidase Alpha Class 1A Member 13
HUMM32     EC 3.2.18
HUMM92     

External Ids:    HGNC: 68211   Entrez Gene: 41212   Ensembl: ENSG000001118857   OMIM: 6043445   UniProtKB: P339083   

Export aliases for MAN1A1 gene to outside databases

Previous GC identifers: GC06M119269 GC06M119456 GC06M119479 GC06M117081


Summaries
for MAN1A1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MAN1A1:
This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein
catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and
belongs to family 47 of glycosyl hydrolases. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: MA1A1_HUMAN, P33908
Function: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose
residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)

Gene Wiki entry for MAN1A1


Genomic Views
for MAN1A1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAN1A1 gene promoter:
         STAT5B   AhR   C/EBPbeta   Sp1   Pax-2   Pax-2a   E47   NRF-2   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAN1A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAN1A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAN1A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22   Ensembl cytogenetic band:  6q22.31   HGNC cytogenetic band: 6q22

MAN1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAN1A1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M119540:  view genomic region     (about GC identifiers)

Start:
 119,498,374 bp from pter      End:
 119,670,926 bp from pter
Size:
 172,553 bases      Orientation:
 minus strand

Proteins
for MAN1A1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MA1A1_HUMAN, P33908 (See protein sequence)
Recommended Name: Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA  
Size: 653 amino acids; 72969 Da
Cofactor: Calcium
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein
Secondary accessions: Q9NU44 Q9UJI3

Explore the universe of human proteins at neXtProt for MAN1A1: NX_P33908

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P33908

    • 4/15 DME Specific Peptides for MAN1A1 (P33908) (see all 15)
     QSFFLAE  SGVLFHS  DSFYEYL  FFLPDSSK 

    MAN1A1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005898.2  
    ENSEMBL proteins: 
     ENSP00000357453   ENSP00000357451  
    Reactome Protein details: P33908
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    Uscn Proteins for MAN1A1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005624membrane fraction ----
    GO:0005783endoplasmic reticulum TAS8223597
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA15308636
    GO:0016020membrane TAS8223597


    MAN1A1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for MAN1A1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MAN1A1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001382 Glyco_hydro_47

    Graphical View of Domain Structure for InterPro Entry P33908

    ProtoNet protein and cluster: P33908

    1 Blocks protein family: IPB001382 Glycosyl hydrolase family 47 signature

    UniProtKB/Swiss-Prot: MA1A1_HUMAN, P33908
    Similarity: Belongs to the glycosyl hydrolase 47 family


    Function
    for MAN1A1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MA1A1_HUMAN, P33908
    Function: Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose
    residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)
    Catalytic activity: Hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose
    oligosaccharide Man(9)(GlcNAc)(2)
    Enzyme regulation: Inhibited by both 1-deoxymannojirimycin and kifunensine

         Genatlas biochemistry entry for MAN1A1:
    mannosyl-oligo saccharide alpha-1,2-mannosidase,class 1A,member 1,membrane type,expressed in kidney,located in
    endoplasmic reticulum,involved in processing of Asp-linked (N) glycans

    Enzyme Numbers (IUBMB): EC 3.2.1.1131 2 EC 3.2.12

    miRNA
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    hsa-miR-485-5p hsa-miR-323-3p hsa-miR-607 hsa-miR-3607-5p hsa-miR-19b-2* hsa-miR-507 hsa-miR-3125 hsa-miR-3916
    SwitchGear 3'UTR luciferase reporter plasmid: MAN1A1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004571mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0015923mannosidase activity TAS8223597


    MAN1A1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for MAN1A1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Asparagine N-linked glycosylation
    		Asparagine N-linked glycosylation1.00
    		Post-translational protein modification0.44
    		N-Glycan biosynthesis0.52
    		Metabolism of proteins0.15
    2N-glycan trimming and elongation in the cis-Golgi
    		N-glycan trimming and elongation in the cis-Golgi1.00
    		Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc20.60
    3Protein processing in endoplasmic reticulum
    		Protein processing in endoplasmic reticulum1.00
    4N-glycan antennae elongation in the medial/trans-Golgi
    		Transport to the Golgi and subsequent modification0.56
    5Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for MAN1A1 (see all 6)
        Transport to the Golgi and subsequent modification
    Asparagine N-linked glycosylation
    Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2
    Metabolism of proteins
    Post-translational protein modification


    3         Kegg Pathways  (Kegg details for MAN1A1):
        N-Glycan biosynthesis
    Metabolic pathways
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: MA1A1_HUMAN, P33908
    Pathway: Protein modification; protein glycosylation


    MAN1A1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MAN1A1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for MAN1A1 (ENSP000003574534) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    GANABENSP000003404664STRING: ENSP00000340466
    MGAT1ENSP000003118884STRING: ENSP00000311888
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--


    MAN1A1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MAN1A1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MAN1A1 for compounds           About GeneDecksing

    EMD Millipore small molecules for MAN1A1:
    Small Molecule - inhibitor
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    3 HMDB Compounds for MAN1A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    D-MannoseDL-mannose (see all 13)3458-28-4--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for MAN1A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-D-Mannose-- 3458-28-4target--10592235

    2 Novoseek chemical compound relationships for MAN1A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    swainsonine 85.8 1 7588811 (1)
    polysaccharide 32.6 1 7881169 (1)

    Search CenterWatch for drugs/clinical trials and news about MAN1A1 / MA1A1 

    Transcripts
    for MAN1A1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MAN1A1 gene: 
    NM_005907.3  

    Unigene Cluster for MAN1A1:

    Mannosidase, alpha, class 1A, member 1
    Hs.102788  [show with all ESTs]
    Unigene Representative Sequence: NM_005907
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368468(uc003pym.1) ENST00000368466(uc010kei.2)

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    SwitchGear 3'UTR luciferase reporter plasmid: MAN1A1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: MAN1A1
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    Clone
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    Additional cDNA sequence: 

    AK024588.1 AK025599.1 AK307383.1 BC065827.1 

    12 DOTS entries:

    DT.415434  DT.91831498  DT.95170144  DT.101983394  DT.91765816  DT.100672272  DT.91721437  DT.212672 
    DT.101961124  DT.100730562  DT.100797253  DT.70104126 

    24/202 AceView cDNA sequences (see all 202):

    CA867323 AV701089 H01223 BQ632635 C05721 BU607962 AI370722 BX102630 
    AA639524 AA642577 BG656417 AA418381 BQ024461 AI421694 NM_005907 AW074342 
    BI491218 AW074081 AA262830 AV709183 AA489636 AI440055 BM510807 CB269881 

    GeneLoc Exon Structure


    Expression
    for MAN1A1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAN1A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGTTTTCAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MAN1A1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneStylopod Long BoneBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Trophoblast-like cells (Generation of tropho...)

    See MAN1A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAN1A1

    SOURCE GeneReport for Unigene cluster: Hs.102788
        SABiosciences Expression via Pathway-Focused PCR Array including MAN1A1: 
              Glycosylation in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for MAN1A1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MAN1A1 gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves MAN1A11 mannosidase, alpha, class 1A, member 1 77.29(n)
    83.17(a)    		   421726  XM_419762.3  XP_419762.3 
    lizard
    (Anolis carolinensis)    		 Reptilia MAN1A16
    		 --
    		 74(a)
    		 1 ↔ 1
    		 1(184544334-184602541)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.342752 Xenopus laevis transcribed sequence with moderate similarity more 82.08(n)    BJ625611.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii man1a11 mannosidase, alpha, class 1A, member 1 68.25(n)
    74.35(a)    		   566078  XM_689343.5  XP_694435.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta alpha-Man-I3 N-linked glycosylation
    mannosyl-oligosaccharide
    more    		 58(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea C52E4.51 , 3 alpha 1,2, mannosidase3
    Protein C52E4.51    		 50(a)
    (best of 2)3
    55.38(n)1
    51.12(a)1    		   V(11985739-11988071)3
    1796421  NM_073605.41  NP_506006.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MNS21 mannosyl-oligosaccharide 1,2-alpha-mannosidase MNS2 51.46(n)
    45.21(a)    		   821668  NM_113010.2  NP_566675.1 
    rice
    (Oryza sativa)    		 Liliopsida Os04g06064001 hypothetical protein 50.75(n)
    45.31(a)    		   4336917  NM_001060335.1  NP_001053800.1 


    ENSEMBL Gene Tree for MAN1A1 (if available)
    TreeFam Gene Tree for MAN1A1 (if available) 

    Paralogs
    for MAN1A1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAN1A1 gene
    MAN1C12  MAN1B12  MAN1A22  
    4 SIMAP similar genes for MAN1A1 using alignment to 2 protein entries:     MA1A1_HUMAN (see all proteins):
    pp6318    MAN1C1    MAN1A2    MAN1B1

    MAN1A1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MAN1A1
    PGOHUM00000234536


    Genomic Variants
    for MAN1A1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3277 NCBI SNPs in MAN1A1 are shown (see all 3277)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs119699051,2
    		C,H,--119497880(+) GAAAAA/GTTTCG 1 -- ds50014Minor allele frequency- G:0.00NS EA 414
    rs65690531,2
    		C,F,A,H,--119497884(+) AATTTC/TGGAGG 1 -- ds500127Minor allele frequency- T:0.35NA NS EA WA CSA 2898
    rs1399603301,2
    		--119497978(+) ATATAG/TAATTT 1 -- ds50010--------
    rs603111771,2
    		C,--119498100(+) TTTGTG/TCTATT 1 -- ds50012Minor allele frequency- T:0.11WA 120
    rs1840803631,2
    		--119498117(+) ATCAAA/CGCTTC 1 -- ds50010--------
    rs170808571,2
    		C,F,H,--119498153(+) ATATGT/CTAGAT 1 -- ds50019Minor allele frequency- C:0.05NA NS EA WA 682
    rs1435054971,2
    		--119498176(+) TTATTG/TGATTA 1 -- ds50010--------
    rs1124498341,2
    		--119498243(+) TTTCCT/CTGTCA 1 -- ds50012Minor allele frequency- C:0.05CSA WA 119
    rs1892574341,2
    		--119498265(+) GTGTGG/TTATGG 1 -- ds50010--------
    rs794652211,2
    		C,--119498280(+) CTGTT-/AAGGAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MAN1A1 (119498374 - 119670926 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MAN1A1
         1 Indel: 99682

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    Disorders / Diseases
    for MAN1A1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MAN1A1 for disorders           About GeneDecksing

    OMIM gene information: 604344    OMIM disorders: --

    2 diseases for MAN1A1:    About MalaCards
    mannosidase deficiency disease    immunodeficiency

    Human Genome Epidemiology (HuGE) Navigator: MAN1A1 (2 documents)

    Export disorders for MAN1A1 gene to outside databases

    Publications
    for MAN1A1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAN1A1 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with MAN1A1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and primary structure of Man9-mannosidase from human kidney. (PubMed id 8223597)1, 2, 3, 9 Bause E.... Schmidt B. (1993)
    2. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    3. Man9-mannosidase from human kidney is expressed in COS cells as a Golgi-resident type II transmembrane N-glycoprotein. (PubMed id 7588811)1, 9 Bieberich E. and Bause E. (1995)
    4. Man9-mannosidase from pig liver is a type-II membrane protein that resides in the endoplasmic reticulum. cDNA cloning and expression of the enzyme in COS 1 cells. (PubMed id 9219526)1, 9 Bieberich E....Bause E. (1997)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Differential expression and function of I+-mannosidase I in stimulated naive and memory CD4+ T cells. (PubMed id 21577142)1 Gebuhr I....Sawitzki B. (2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. The mammalian UPR boosts glycoprotein ERAD by suppres sing the proteolytic downregulation of ER mannosidase I. (PubMed id 19258393)1 Termine D.J....Sifers R.N. (2009)
    9. HIV-1 gp120 N-linked glycosylation differs between pla sma and leukocyte compartments. (PubMed id 18215327)1 Ho Y.S....Saksena N.K. (2008)
    10. Env length and N-linked glycosylation following transm ission of human immunodeficiency virus Type 1 subtype B viruses. (PubMed id 18314154)1 Liu Y....Mullins J.I. (2008)

    External Searches for MAN1A1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing MAN1A1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4121 HGNC: 6821 AceView: MAN1A1 Ensembl:ENSG00000111885 euGenes: HUgn4121
    ECgene: MAN1A1 Kegg: 4121 H-InvDB: MAN1A1

    Other Databases showing MAN1A1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MAN1A1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAN1A1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MAN1A1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MAN1A1 gene:
    Search GeneIP for patents involving MAN1A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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