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Aliases for MAML3 Gene

Aliases for MAML3 Gene

  • Mastermind-Like 3 (Drosophila) 2 3
  • Trinucleotide Repeat Containing 3 2 3
  • KIAA1816 4 6
  • Mam-3 3 4
  • MAM2 3 6
  • CAG Repeat Containing (Glia-Derived Nexin I Alpha) 3
  • Expanded Repeat Domain, CAG/CTG 3 3
  • Mastermind (Drosophila)-Like 3 2
  • Mastermind-Like Protein 3 3
  • Polyglutamine Rich 3
  • CAG Repeat Domain 3
  • CAGH3 3
  • ERDA3 3
  • MAM-2 3
  • TNRC3 3
  • GDN 3

External Ids for MAML3 Gene

Previous Symbols for MAML3 Gene

  • TNRC3

Summaries for MAML3 Gene

GeneCards Summary for MAML3 Gene

MAML3 (Mastermind-Like 3 (Drosophila)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is MAML1.

UniProtKB/Swiss-Prot for MAML3 Gene

  • Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAML3 Gene

Genomics for MAML3 Gene

Genomic Location for MAML3 Gene

139,716,391 bp from pter
140,154,184 bp from pter
437,794 bases
Minus strand

Genomic View for MAML3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAML3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAML3 Gene

Regulatory Elements for MAML3 Gene

Proteins for MAML3 Gene

  • Protein details for MAML3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mastermind-like protein 3
    Protein Accession:
    Secondary Accessions:
    • B2RNU9
    • B3KVV7
    • E7EVW8

    Protein attributes for MAML3 Gene

    1138 amino acids
    Molecular mass:
    122293 Da
    Quaternary structure:
    • Interacts through its N-terminal region with the ankyrin repeat region of the Notch proteins NOTCH1, NOTCH2, NOTCH3 and NOTCH4. Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa.
    • Sequence=BAB47445.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG53919.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for MAML3 Gene

Proteomics data for MAML3 Gene at MOPED

Post-translational modifications for MAML3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAML3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MAML3 Gene

Domains for MAML3 Gene

Protein Domains for MAML3 Gene


  • The C-terminal domain is required for transcriptional activation.:
    • Q96JK9
  • Belongs to the mastermind family.:
    • Q96JK9
genes like me logo Genes that share domains with MAML3: view

No data available for Gene Families for MAML3 Gene

Function for MAML3 Gene

Molecular function for MAML3 Gene

UniProtKB/Swiss-Prot Function: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.

Gene Ontology (GO) - Molecular Function for MAML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 12370315
genes like me logo Genes that share ontologies with MAML3: view
genes like me logo Genes that share phenotypes with MAML3: view

Animal Models for MAML3 Gene

MGI Knock Outs for MAML3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for MAML3 Gene

Localization for MAML3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAML3 Gene

Nucleus speckle. Note=Nuclear, in a punctate manner.

Subcellular locations from

Jensen Localization Image for MAML3 Gene COMPARTMENTS Subcellular localization image for MAML3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MAML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12370315
GO:0005654 nucleoplasm TAS --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with MAML3: view

Pathways for MAML3 Gene

genes like me logo Genes that share pathways with MAML3: view

Pathways by source for MAML3 Gene

Gene Ontology (GO) - Biological Process for MAML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007219 Notch signaling pathway TAS --
GO:0010467 gene expression TAS --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 12370315
genes like me logo Genes that share ontologies with MAML3: view

Transcripts for MAML3 Gene

mRNA/cDNA for MAML3 Gene

Unigene Clusters for MAML3 Gene

Mastermind-like 3 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAML3 Gene

No ASD Table

Relevant External Links for MAML3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAML3 Gene

mRNA expression in normal human tissues for MAML3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MAML3 Gene

SOURCE GeneReport for Unigene cluster for MAML3 Gene Hs.586165

genes like me logo Genes that share expressions with MAML3: view

Orthologs for MAML3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MAML3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAML3 36
  • 99.56 (n)
  • 99.73 (a)
MAML3 37
  • 97 (a)
(Bos Taurus)
Mammalia MAML3 36
  • 87.82 (n)
  • 90.52 (a)
MAML3 37
  • 87 (a)
(Canis familiaris)
Mammalia MAML3 36
  • 86.62 (n)
  • 89.05 (a)
MAML3 37
  • 86 (a)
(Mus musculus)
Mammalia Maml3 36
  • 86.04 (n)
  • 88.27 (a)
Maml3 16
Maml3 37
  • 84 (a)
(Monodelphis domestica)
Mammalia MAML3 37
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia MAML3 37
  • 81 (a)
(Rattus norvegicus)
Mammalia Maml3 36
  • 86.02 (n)
  • 88.94 (a)
(Gallus gallus)
Aves MAML3 36
  • 78.77 (n)
  • 79.12 (a)
MAML3 37
  • 75 (a)
(Anolis carolinensis)
Reptilia MAML3 37
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia maml3 36
  • 69.96 (n)
  • 67.93 (a)
(Danio rerio)
Actinopterygii LOC101886283 36
  • 64.77 (n)
  • 59.68 (a)
maml3 37
  • 47 (a)
Species with no ortholog for MAML3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAML3 Gene

Gene Tree for MAML3 (if available)
Gene Tree for MAML3 (if available)

Paralogs for MAML3 Gene

Paralogs for MAML3 Gene

Selected SIMAP similar genes for MAML3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MAML3: view

Variants for MAML3 Gene

Sequence variations from dbSNP and Humsavar for MAML3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs2153 -- 139,751,139(+) AATAA(C/T)AAAAT intron-variant
rs706351 -- 139,918,848(-) AGAAA(C/T)GATTC intron-variant
rs716415 -- 139,915,837(+) TCCTC(C/T)GGAAT intron-variant
rs734209 -- 139,920,247(+) TAAGT(A/C)AGAAC intron-variant
rs736349 -- 139,902,581(-) TTCCA(C/T)GTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAML3 Gene

Variant ID Type Subtype PubMed ID
nsv525242 CNV Loss 19592680
nsv290100 CNV Loss 16902084
esv2728428 CNV Deletion 23290073
esv2131682 CNV Deletion 18987734
esv2728430 CNV Deletion 23290073
esv2728431 CNV Deletion 23290073
esv2728432 CNV Deletion 23290073
esv260048 OTHER Complex 20981092
nsv291396 CNV Loss 16902084
nsv830087 CNV Gain 17160897
esv273356 CNV Insertion 20981092
esv269496 CNV Insertion 20981092
esv272206 CNV Insertion 20981092
esv272038 CNV Insertion 20981092
nsv292145 CNV Loss 16902084
nsv822749 CNV Loss 20364138
esv2728433 CNV Deletion 23290073
esv2662572 CNV Deletion 23128226

Relevant External Links for MAML3 Gene

HapMap Linkage Disequilibrium report

Disorders for MAML3 Gene

Relevant External Links for MAML3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MAML3: view

No data available for UniProtKB/Swiss-Prot for MAML3 Gene

Publications for MAML3 Gene

  1. Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. (PMID: 12370315) Wu L. … Griffin J.D. (Mol. Cell. Biol. 2002) 2 3 4
  2. Identification of new human mastermind proteins defines a family that consists of positive regulators for Notch signaling. (PMID: 12386158) Lin S.-E. … Kitagawa M. (J. Biol. Chem. 2002) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4

Products for MAML3 Gene

Sources for MAML3 Gene

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