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MAML3 Gene

protein-coding   GIFtS: 53
GCID: GC04M140637

Mastermind-Like 3 (Drosophila)

(Previous name: trinucleotide repeat containing 3)
(Previous symbol: TNRC3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mastermind-Like 3 (Drosophila)1 2     MAM-22
TNRC31 2     CAG Repeat Containing (Glia-Derived Nexin I Alpha)2
Trinucleotide Repeat Containing 31 2     CAG Repeat Domain2
MAM22 5     Expanded Repeat Domain, CAG/CTG 32
KIAA18163 5     mam-32
Mastermind (Drosophila)-Like 31     Mastermind-Like Protein 32
CAGH32     Polyglutamine Rich2
ERDA32     Mam-33
GDN2     

External Ids:    HGNC: 162721   Entrez Gene: 555342   Ensembl: ENSG000001967827   OMIM: 6089915   UniProtKB: Q96JK93   

Export aliases for MAML3 gene to outside databases

Previous GC identifers: GC04U900023 GC04M141105 GC04M141217 GC04M141216 GC04M140996 GC04M140856 GC04M136366


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MAML3 Gene:
MAML3 (mastermind-like 3 (Drosophila)) is a protein-coding gene. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is MAML2.

UniProtKB/Swiss-Prot: MAML3_HUMAN, Q96JK9
Function: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced
transcription of HES1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the MAML3 gene promoter:
         Elk-1   FOXF2   HTF   Lmo2   YY1   c-Ets-1   CREB   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAML3 promoter sequence
   Search Chromatin IP Primers for MAML3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MAML3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28   Ensembl cytogenetic band:  4q31.1   HGNC cytogenetic band: 4q28

MAML3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAML3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M140637:  view genomic region     (about GC identifiers)

Start:
140,637,545 bp from pter      End:
141,075,338 bp from pter
Size:
437,794 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MAML3_HUMAN, Q96JK9 (See protein sequence)
Recommended Name: Mastermind-like protein 3  
Size: 1134 amino acids; 121780 Da
Subunit: Interacts through its N-terminal region with the ankyrin repeat region of the Notch proteins NOTCH1,
NOTCH2, NOTCH3 and NOTCH4. Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa
Sequence caution: Sequence=BAB47445.1; Type=Erroneous initiation; Sequence=BAG53919.1; Type=Erroneous initiation;
Secondary accessions: B2RNU9 B3KVV7

Explore the universe of human proteins at neXtProt for MAML3: NX_Q96JK9

Explore proteomics data for MAML3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MAML3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061187.2  
    ENSEMBL proteins: 
     ENSP00000421180   ENSP00000422783   ENSP00000313316   ENSP00000381913  
    Reactome Protein details: Q96JK9

    MAML3 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAML3

     
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    antibodies-online proteins for MAML3 (2 products) 

     
    antibodies-online peptides for MAML3

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    antibodies-online kits for MAML3 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019082 Neuroggenic_mastermind-like_N

    Graphical View of Domain Structure for InterPro Entry Q96JK9

    ProtoNet protein and cluster: Q96JK9

    UniProtKB/Swiss-Prot: MAML3_HUMAN, Q96JK9
    Domain: The C-terminal domain is required for transcriptional activation
    Similarity: Belongs to the mastermind family


    Find genes that share domains with MAML3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAML3_HUMAN, Q96JK9
    Function: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced
    transcription of HES1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA12370315
         
    Find genes that share ontologies with MAML3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for MAML3:
     Decreased viability with cispl  High actin ratio cells  Increased gamma-H2AX phosphory 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Maml3):
     cardiovascular system  cellular  craniofacial  embryogenesis  growth/size/body 
     mortality/aging  nervous system  normal 

    Find genes that share phenotypes with MAML3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Maml3tm1Mkit for MAML3

       genOway: Develop your customized and physiologically relevant rodent model for MAML3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat MAML3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MAML3 (see all 69):
    hsa-miR-548j hsa-miR-3130-5p hsa-miR-323-3p hsa-miR-411 hsa-miR-138-2* hsa-miR-519a hsa-miR-3613-3p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidMAML3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MAML3
    Predesigned siRNA for gene silencing in human, mouse, rat MAML3

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: MAML3 (NM_018717)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAML3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAML3

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAML3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MAML3_HUMAN, Q96JK9: Nucleus speckle. Note=Nuclear, in a punctate manner
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12370315
    GO:0005654nucleoplasm TAS--
    GO:0016607nuclear speck IEA--

    Find genes that share ontologies with MAML3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MAML3 About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Notch signaling pathway (KEGG)
    Notch signaling pathway0.84
    Delta-Notch Signaling Pathway0.33
    Notch Signaling Pathway0.84
    Notch Signaling0.30
    2Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH10.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    3Pre-NOTCH Expression and Processing
    Pre-NOTCH Expression and Processing0.62
    Notch-HLH transcription pathway0.00
    Pre-NOTCH Transcription and Translation0.62
    4Signaling by NOTCH2
    Signaling by NOTCH20.67
    NOTCH2 intracellular domain regulates transcription0.00
    5Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40


    Find genes that share SuperPaths with MAML3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for MAML3
        Notch Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for MAML3
        Notch Signaling

    2 BioSystems Pathways for MAML3
        Notch Signaling Pathway
    Delta-Notch Signaling Pathway

    Selected Reactome Pathways for MAML3 (see all 6)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    Pre-NOTCH Transcription and Translation
    Notch-HLH transcription pathway
    NOTCH2 intracellular domain regulates transcription


    1 Kegg Pathway  (Kegg details for MAML3):
        Notch signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MAML3
    Interactions:

        Search GeneGlobe Interaction Network for MAML3

    Selected Interacting proteins for MAML3 (Q96JK93) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000223355Q994663I2D: score=1 
    ENSG00000234876Q994663I2D: score=1 
    ENSG00000238196Q994663I2D: score=1 
    NOTCH4Q994663I2D: score=1 
    MEF2CQ064133I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007219Notch signaling pathway TAS--
    GO:0010467gene expression TAS--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA12370315

    Find genes that share ontologies with MAML3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MAML3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MAML3 gene: 
    NM_018717.4  

    Unigene Cluster for MAML3:

    Mastermind-like 3 (Drosophila)
    Hs.586165  [show with all ESTs]
    Unigene Representative Sequence: NM_018717
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509479(uc021xsg.1 uc011chd.1) ENST00000502696 ENST00000327122
    ENST00000398940
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MAML3 (see all 69):
    hsa-miR-548j hsa-miR-3130-5p hsa-miR-323-3p hsa-miR-411 hsa-miR-138-2* hsa-miR-519a hsa-miR-3613-3p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidMAML3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: MAML3 (NM_018717)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAML3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for MAML3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MAML3
      QuantiTect SYBR Green Assays in human, mouse, rat MAML3
      QuantiFast Probe-based Assays in human, mouse, rat MAML3

    Additional mRNA sequence: 

    AK123604.1 AK296891.1 AL359614.1 BC137130.1 BC137131.1 Z36807.1 

    5 DOTS entries:

    DT.108622  DT.121236347  DT.95364681  DT.121236359  DT.75134023 

    Selected AceView cDNA sequences (see all 85):

    CF131890 CA841254 AI281258 BM127097 CK818823 BI771115 NM_018717 AI423405 
    AL359614 BQ023432 BM451117 AI627489 AI690905 BQ632192 BF868805 BE263879 
    AA814526 AI139957 AA236382 AI418583 AW991384 AI343457 BX506733 AA287173 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MAML3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAGCTGGG
    MAML3 Expression
    About this image


    MAML3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
    MAML3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MAML3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.586165
        Custom PCR Arrays for MAML3
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAML3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MAML3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Maml31 , 5 mastermind like 3 (Drosophila)1, 5 86.04(n)1
    88.27(a)1
      3 (22.54 cM)5
    4335861  NM_001004176.21  NP_001004176.21 
     516876115 
    chicken
    (Gallus gallus)
    Aves MAML31 mastermind-like 3 (Drosophila) 78.77(n)
    79.12(a)
      422445  XM_420411.4  XP_420411.4 
    lizard
    (Anolis carolinensis)
    Reptilia MAML36
    mastermind-like 3 (Drosophila)
    73(a)
    1 ↔ 1
    5(120039662-120164690)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia maml31 mastermind-like 3 69.96(n)
    67.93(a)
      100158633  XM_002932046.2  XP_002932092.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018862831 mastermind-like protein 3-like 64.77(n)
    59.68(a)
      101886283  XM_005160012.1  XP_005160069.1 


    ENSEMBL Gene Tree for MAML3 (if available)
    TreeFam Gene Tree for MAML3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MAML3 gene
    MAML22  MAML12  
    3 SIMAP similar genes for MAML3 using alignment to 5 protein entries:     MAML3_HUMAN (see all proteins):
    DKFZp762E1511    CAGH3    MAML1

    Find genes that share paralogs with MAML3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MAML3 (see all 7933)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs588325491,2
    C--136575676(+) GAGCC-/AAGTG 
     GGGC
    /AC
    TGGAT
    2 -- int1 cds10--------
    rs106031371,2
    C--140650332(+) aaaaa-/A/AA/AAA
    AAAAAAAAAA
    GGGAA
    1 -- int11NA 2
    rs2000185801,2
    C--140658468(+) TTTTT-/TAAGCC 1 -- int10--------
    rs580710601,2
    C--140658516(+) GTCTGATGTCCCA
    CAGCTG
    /-
    GTGGT
    1 -- int11Minor allele frequency- -:0.00NA 2
    rs588640791,2
    C--140660836(+) AGTTTCTTT/-  
            
    TTTTT
    1 -- int11Minor allele frequency- -:0.00NA 2
    rs1510702581,2
    --140662444(+) GGTCCA/GTGAGG 1 -- int10--------
    rs1891090571,2
    --140662483(+) CCTGAC/TCCTGG 1 -- int10--------
    rs1815052341,2
    --140662508(+) AGAACC/TTTGAG 1 -- int10--------
    rs1395671391,2
    --140662535(+) TATTCC/TTCGAA 1 -- int10--------
    rs756806441,2
    C--140662537(+) TTCTTC/TGAACA 1 -- int13Minor allele frequency- T:0.10NA EA 242

    HapMap Linkage Disequilibrium report for MAML3 (140637545 - 140887545 bp, first 250kb of MAML3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for MAML3 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2728433CNV Deletion23290073
    esv2728432CNV Deletion23290073
    esv2728431CNV Deletion23290073
    esv2131682CNV Deletion18987734
    esv2728430CNV Deletion23290073
    esv2728428CNV Deletion23290073
    esv2662572CNV Deletion23128226
    esv272038CNV Insertion20981092
    esv273356CNV Insertion20981092
    esv269496CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608991    OMIM disorders: --


    Find genes that share disorders with MAML3           About GenesLikeMe

    Genetic Association Database (GAD): MAML3
    Human Genome Epidemiology (HuGE) Navigator: MAML3 (1 document)

    Export disorders for MAML3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MAML3 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with MAML3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. (PubMed id 12370315)1, 2, 3 Wu L.... Griffin J.D. (Mol. Cell. Biol. 2002)
    2. Identification of new human mastermind proteins defines a family that consists of positive regulators for Notch signaling. (PubMed id 12386158)1, 2, 3 Lin S.-E.... Kitagawa M. (J. Biol. Chem. 2002)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    6. A genome-wide association study identifies two risk loci for congenital heart malformations in Han Chinese populations. (PubMed id 23708190)1 Hu Z....Shen H. (Nat. Genet. 2013)
    7. NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (Mol. Cell 2012)
    8. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    9. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55534 HGNC: 16272 AceView: MAML3 Ensembl:ENSG00000196782 euGenes: HUgn55534
    ECgene: MAML3 Kegg: 55534 H-InvDB: MAML3

    (According to HUGE)
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    HUGE: KIAA1816

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MAML3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MAML3 gene:
    Search GeneIP for patents involving MAML3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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