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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAML2 Gene

protein-coding   GIFtS: 55
GCID: GC11M095711

Mastermind-Like 2 (Drosophila)

(Previous name: mastermind (Drosophila)-like 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mastermind-Like 2 (Drosophila)1 2     MLL-MAML22
MAM32 5     mam-22
Mastermind (Drosophila)-Like 21     Mastermind-Like Protein 22
MAM-32     KIAA18193
MAM22     Mam-23

External Ids:    HGNC: 162591   Entrez Gene: 844412   Ensembl: ENSG000001843847   OMIM: 6075375   UniProtKB: Q8IZL23   

Export aliases for MAML2 gene to outside databases

Previous GC identifers: GC11M097219 GC11M095895 GC11M095399 GC11M095351


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MAML2 Gene: 
MAML2 (mastermind-like 2 (Drosophila)) is a protein-coding gene. Diseases associated with MAML2 include cutaneous mucoepidermoid carcinoma, and lipoadenoma, and among its related super-pathways are Constitutive Signaling by NOTCH1 PEST Domain Mutants and Notch signaling pathway. GO annotations related to this gene include transcription coactivator activity. An important paralog of this gene is MAML3.

UniProtKB/Swiss-Prot: MAML2_HUMAN, Q8IZL2
Function: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced
transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3

Gene Wiki entry for MAML2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAML2 gene promoter:
         Egr-3   Pax-5   Ik-3   YY1   E47   PPAR-alpha   POU2F1   POU2F1a   Hand1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAML2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAML2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAML2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q21   Ensembl cytogenetic band:  11q21   HGNC cytogenetic band: 11q

MAML2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAML2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M095711:  view genomic region     (about GC identifiers)

Start:
95,709,762 bp from pter      End:
96,076,344 bp from pter
Size:
366,583 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MAML2_HUMAN, Q8IZL2 (See protein sequence)
Recommended Name: Mastermind-like protein 2  
Size: 1156 amino acids; 125197 Da
Subunit: Interacts through its N-terminal region with the ankyrin repeat region of the Notch proteins NOTCH1,
NOTCH2, NOTCH3 and NOTCH4. Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa
Subcellular location: Nucleus speckle. Note=Nuclear, in a punctate manner
Sequence caution: Sequence=AAK93833.1; Type=Erroneous initiation; Sequence=AAP12462.1; Type=Erroneous initiation;
Sequence=BAB47448.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A7MD26 Q6AI23 Q6Y3A3 Q8IUL3 Q96JK6

Explore the universe of human proteins at neXtProt for MAML2: NX_Q8IZL2

Explore proteomics data for MAML2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IZL2

  • MAML2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MAML2 Protein Expression
    REFSEQ proteins: NP_115803.1  
    ENSEMBL proteins: 
     ENSP00000434552  
    Reactome Protein details: Q8IZL2
    Human Recombinant Protein Products for MAML2: 
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    Novus Biologicals MAML2 Protein
    Novus Biologicals MAML2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MAML2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005794Golgi apparatus IDA--
    GO:0016607nuclear speck IEA--

    MAML2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019082 Neuroggenic_mastermind-like_N

    Graphical View of Domain Structure for InterPro Entry Q8IZL2

    ProtoNet protein and cluster: Q8IZL2

    UniProtKB/Swiss-Prot: MAML2_HUMAN, Q8IZL2
    Domain: The C-terminal domain is required for transcriptional activation
    Similarity: Belongs to the mastermind family


    MAML2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MAML2_HUMAN, Q8IZL2
    Function: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced
    transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA12370315
         
    MAML2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MAML2:
     Decreased TP53 protein express 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MAML2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MAML2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MAML2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MAML2 

    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate MAML2:
    hsa-miR-148b* hsa-miR-4254 hsa-miR-520f hsa-miR-466 hsa-miR-1261 hsa-miR-512-3p
    SwitchGear 3'UTR luciferase reporter plasmidMAML2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MAML2 About   (see all 10)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.89
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.89
    Signaling by NOTCH1 in Cancer0.79
    Signaling by NOTCH1 t(7 9)(NOTCH1:M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH10.79
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH0.74
    2Notch signaling pathway
    Notch signaling pathway0.84
    Delta-Notch Signaling Pathway0.33
    3NOTCH2 intracellular domain regulates transcription
    Signaling by NOTCH20.66
    NICD traffics to nucleus0.32
    NOTCH2 intracellular domain regulates transcription0.38
    Notch-HLH transcription pathway0.32
    4Generic Transcription Pathway
    Gene Expression0.47
    Generic Transcription Pathway0.47
    5Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for MAML2
        Notch Signaling Pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MAML2
        Notch Signaling

    1 Cell Signaling Technology (CST) Pathway for MAML2
        Wnt / Hedgehog / Notch

    3 BioSystems Pathways for MAML2
        Delta-Notch Signaling Pathway
    Notch signaling pathway
    Notch-mediated HES/HEY network

    5/19        Reactome Pathways for MAML2 (see all 19)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    FBXW7 Mutants and NOTCH1 in Cancer
    Notch-HLH transcription pathway
    Signaling by NOTCH1 HD Domain Mutants in Cancer


    1         Kegg Pathway  (Kegg details for MAML2):
        Notch signaling pathway


    MAML2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAML2

    5/10 Interacting proteins for MAML2 (Q8IZL23) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000223355Q994663I2D: score=1 
    ENSG00000234876Q994663I2D: score=1 
    ENSG00000238196Q994663I2D: score=1 
    NOTCH4Q994663I2D: score=1 
    NOTCH1P465313I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007219Notch signaling pathway TAS--
    GO:0010467gene expression TAS--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA12370315

    MAML2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MAML2

    Search CenterWatch for drugs/clinical trials and news about MAML2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAML2 gene: 
    NM_032427.2  

    Unigene Cluster for MAML2:

    Mastermind-like 2 (Drosophila)
    Hs.745167  [show with all ESTs]
    Unigene Representative Sequence: CR627398
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000524717(uc001pfw.1)
    miRNA
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    hsa-miR-148b* hsa-miR-4254 hsa-miR-520f hsa-miR-466 hsa-miR-1261 hsa-miR-512-3p
    SwitchGear 3'UTR luciferase reporter plasmidMAML2 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: MAML2 (NM_032427)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAML2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAML2
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    Additional mRNA sequence: 

    AB058722.1 AK308157.1 AY040322.1 AY186997.1 BC143529.1 BC152449.1 CR627398.1 DQ084494.1 
    DQ886023.1 DQ886024.1 

    5 DOTS entries:

    DT.86837777  DT.105402  DT.100017295  DT.120741795  DT.97822430 

    24/63 AceView cDNA sequences (see all 63):

    BX476471 CR627398 BQ435054 AW439287 CR610618 NM_032427 BQ219346 BM992400 
    CA436800 BG623583 BG620267 BI860842 BG911278 AW966636 AI769569 CK823640 
    CK823639 AB058722 BU684919 BG548350 BQ129427 BQ129276 AL701122 AI480151 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAML2 expression in normal human tissues (normalized intensities)      MAML2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MAML2 Expression
    About this image


    MAML2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)
             Oligodendrocyte Precursor Cells Forebrain White Matter
     
     Spleen (Hematopoietic System)

    See MAML2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAML2

    SOURCE GeneReport for Unigene cluster: Hs.745167

    UniProtKB/Swiss-Prot: MAML2_HUMAN, Q8IZL2
    Tissue specificity: Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including MAML2: 
              Notch Signaling Pathway in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAML2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MAML2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Maml21 , 5 mastermind like 2 (Drosophila)1, 5 84.52(n)1
    84.7(a)1
      9 (3.33 cM)5
    2701181  NM_001013813.31  NP_001013835.21 
     136199905 
    chicken
    (Gallus gallus)
    Aves MAML21 mastermind-like 2 (Drosophila) 72.08(n)
    67.25(a)
      428088  XM_003640590.1  XP_003640638.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAML26
    Uncharacterized protein
    45(a)
    1 ↔ 1
    3(195199918-195286347)
    zebrafish
    (Danio rerio)
    Actinopterygii MAML26
    mastermind-like 2 (Drosophila)
    27(a)
    1 ↔ 1
    15(3757398-3773823)


    ENSEMBL Gene Tree for MAML2 (if available)
    TreeFam Gene Tree for MAML2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAML2 gene
    MAML32  MAML12  
    4 SIMAP similar genes for MAML2 using alignment to 2 protein entries:     MAML2_HUMAN (see all proteins):
    MAML2 fusion    MLL/MAML2 fusion    MLL-MAML2    CAGH3

    MAML2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7775 SNPs in MAML2 are shown (see all 7775)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105507851,2
    C--92086507(+) TTATC-/TT    
       
    /TTTT
    TTTTT
    1 -- int10--------
    rs572202871,2
    C--95677415(+) TTTTT-/T/TT  
            
    GAGAC
    1 -- int11NA 2
    rs71147411,2
    C,F,H--95710993(+) AATACG/TTCCAA 1 -- ds500121Minor allele frequency- T:0.06NS EA NA CSA 2626
    rs789036421,2
    C,F--95711009(+) GACAAA/GTTGTT 1 -- ds50012Minor allele frequency- G:0.05CSA WA 119
    rs71147561,2
    C,F,A,H--95711032(+) TATGCA/G/TTTCCT 1 -- ds500126NS EA NA WA CSA 2895
    rs744276221,2
    F--95711047(+) ACTCCG/ATGAAA 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1871912351,2
    --95711101(+) CCAACA/CAAAAC 1 -- ds50010--------
    rs1466851151,2
    --95711126(+) TCTCGC/GTTTTC 1 -- ds50010--------
    rs1893538451,2
    --95711215(+) CTTGGA/GAACAA 1 -- ds50010--------
    rs1816393891,2
    --95711271(+) AGCCAA/TATAAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MAML2 (95709762 - 95959762 bp, first 250kb of MAML2)

    Structural Variations
         Database of Genomic Variants (DGV) 10/27 variations for MAML2 (see all 27):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2304443CNV Deletion18987734
    esv2744943CNV Deletion23290073
    dgv234e199CNV Deletion23128226
    esv2012527CNV Deletion18987734
    esv2422272CNV Deletion17116639
    esv2741034CNV Deletion23290073
    esv2666315CNV Deletion23128226
    dgv235e199CNV Deletion23128226
    esv2609509CNV Deletion19546169
    esv2658561CNV Deletion23128226

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607537    OMIM disorders: --

    UniProtKB/Swiss-Prot: MAML2_HUMAN, Q8IZL2
  • Note=A chromosomal aberration involving MAML2 is found in mucoepidermoid carcinomas, benign Warthin
    tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with CRTC1/MECT1. The fusion protein consists
    of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the
    N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid
    carcinomas

  • 17 diseases for MAML2:    About MalaCards
    cutaneous mucoepidermoid carcinoma    lipoadenoma    clear cell hidradenoma    mucoepidermoid carcinoma
    cervical adenosquamous carcinoma    epithelial-myoepithelial carcinoma    myoepithelial carcinoma    warthin tumor
    hidradenoma    adenosquamous carcinoma    hypospadias    myelodysplastic syndromes
    acute lymphoblastic leukemia    lymphoblastic leukemia    cervicitis    thyroiditis
    leukemia

    8 diseases from the University of Copenhagen DISEASES database for MAML2:
    Mucoepidermoid carcinoma     Hidradenoma     epithelial-myoepithelial carcinoma     Lipoadenoma
    Cervical adenosquamous carcinoma     Lacrimal gland cancer     Necrotizing sialometaplasia     Cutaneous mucoepidermoid carcinoma

    MAML2 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for MAML2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hidradenoma 86.5 2 17334997 (1), 17551948 (1)
    carcinoma mucoepidermoid 72.5 2 16444749 (1), 17334997 (1)
    carcinoma 17.4 1 17551948 (1)
    tumors 11 2 16103063 (1), 17551948 (1)

    Genetic Association Database (GAD): MAML2
    Human Genome Epidemiology (HuGE) Navigator: MAML2 (2 documents)

    Export disorders for MAML2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAML2 gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with MAML2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of new human mastermind proteins defines a family that consists of positive regulators for Notch signaling. (PubMed id 12386158)1, 2, 3 Lin S.-E.... Kitagawa M. (2002)
    2. Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. (PubMed id 12370315)1, 2, 3 Wu L.... Griffin J.D. (2002)
    3. GWAS for discovery and replication of genetic loci as sociated with sudden cardiac arrest in patients with coronary artery disease. (PubMed id 21658281)1, 4 Aouizerat B.E....Tseng Z.H. (2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    6. Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. (PubMed id 19176441)1, 4 Yang J.J....Relling M.V. (2009)
    7. Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion. (PubMed id 15729701)1, 2 Behboudi A.... Stenman G. (2005)
    8. Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. (PubMed id 14720503)1, 2 Enlund F....Stenman G. (2004)
    9. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. (PubMed id 12539049)1, 2 Tonon G.... Kaye F.J. (2003)
    10. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84441 HGNC: 16259 AceView: MAML2 Ensembl:ENSG00000184384 euGenes: HUgn84441
    ECgene: MAML2 Kegg: 84441 H-InvDB: MAML2

    (According to HUGE)
    About This Section
    HUGE: KIAA1819

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAML2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAML2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAML2 gene:
    Search GeneIP for patents involving MAML2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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