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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MAML2 Gene

protein-coding   GIFtS: 54
GCID: GC11M095711

mastermind-like 2 (Drosophila)

(Previous name: mastermind (Drosophila)-like 2 )
 Explore 19 diseases affiliated with
MAML2 via our new
 Human Malady Compendium 
Biological research products
for MAML2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mastermind-Like 2 (Drosophila)1 2     MAM22
MAM31 2 5     MLL-MAML22
KIAA18191 3     Mam-23
Mastermind (Drosophila)-Like 21     Mastermind-Like Protein 22
MAM-32     Mam-23

External Ids:    HGNC: 162591   Entrez Gene: 844412   Ensembl: ENSG000001843847   OMIM: 6075375   UniProtKB: Q8IZL23   

Export aliases for MAML2 gene to outside databases

Previous GC identifers: GC11M097219 GC11M095895 GC11M095399 GC11M095351


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MAML2_HUMAN, Q8IZL2
Function: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced
transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3

Gene Wiki entry for MAML2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MAML2 gene promoter:
         Egr-3   Pax-5   Ik-3   YY1   E47   PPAR-alpha   POU2F1   POU2F1a   Hand1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMAML2 promoter sequence
   Search SABiosciences Chromatin IP Primers for MAML2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAML2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q21   Ensembl cytogenetic band:  11q21   HGNC cytogenetic band: 11q

MAML2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAML2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M095711:  view genomic region     (about GC identifiers)

Start:
95,709,762 bp from pter      End:
96,076,382 bp from pter
Size:
366,621 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MAML2_HUMAN, Q8IZL2 (See protein sequence)
Recommended Name: Mastermind-like protein 2  
Size: 1156 amino acids; 125197 Da
Subunit: Interacts through its N-terminal region with the ankyrin repeat region of the Notch proteins NOTCH1, NOTCH2,
NOTCH3 and NOTCH4. Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa
Subcellular location: Nucleus speckle. Note=Nuclear, in a punctate manner
Sequence caution: Sequence=AAK93833.1; Type=Erroneous initiation; Sequence=AAP12462.1; Type=Erroneous initiation;
Sequence=BAB47448.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A7MD26 Q6AI23 Q6Y3A3 Q8IUL3 Q96JK6

Explore the universe of human proteins at neXtProt for MAML2: NX_Q8IZL2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IZL2

  • MAML2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_115803.1  
    ENSEMBL proteins: 
     ENSP00000434552   ENSP00000412394  
    Reactome Protein details: Q8IZL2
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    Uscn Proteins for MAML2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005794Golgi apparatus IDA--
    GO:0016607nuclear speck IEA--


    MAML2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MAML2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019082 Neuroggenic_mastermind-like_N

    Graphical View of Domain Structure for InterPro Entry Q8IZL2

    ProtoNet protein and cluster: Q8IZL2

    UniProtKB/Swiss-Prot: MAML2_HUMAN, Q8IZL2
    Domain: The C-terminal domain is required for transcriptional activation
    Similarity: Belongs to the mastermind family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MAML2_HUMAN, Q8IZL2
    Function: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced
    transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3

    miRNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA12370315


    MAML2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MAML2:
     Decreased TP53 protein express 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant
    8/12 pathways (see all 12)
    Signaling by NOTCH1 PEST Domain Mutants in Cancer1.00
    Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant1.00
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer1.00
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    Signaling by NOTCH1 in Cancer1.00
    Signaling by NOTCH0.77
    Signaling by NOTCH1 HD Domain Mutants in Cancer1.00
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.71
    2Generic Transcription Pathway
    Generic Transcription Pathway1.00
    Gene Expression0.46
    3Mature NOTCH heterodimer traffics to the plasma membrane
    Notch-HLH transcription pathway0.31
    NICD traffics to nucleus0.31
    4Notch Signaling Pathway
    Notch signaling pathway0.82
    Delta-Notch Signaling Pathway0.27
    5Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for MAML2
        Notch Signaling

    1 Cell Signaling Technology (CST) Pathway for MAML2
        Wnt / Hedgehog / Notch

    3 BioSystems Pathways for MAML2 
        Delta-Notch Signaling Pathway
    Notch-mediated HES/HEY network
    Notch signaling pathway

    5/17        Reactome Pathways for MAML2 (see all 17)
        Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
    NOTCH1 Intracellular Domain Regulates Transcription
    FBXW7 Mutants and NOTCH1 in Cancer
    Notch-HLH transcription pathway
    Signaling by NOTCH1 HD Domain Mutants in Cancer


    1         Kegg Pathway  (Kegg details for MAML2):
        Notch signaling pathway


    MAML2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MAML2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/34 Interacting proteins for MAML2 (Q8IZL23 ENSP000004123944) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREBBPQ927933, ENSP000002623674I2D: score=1 STRING: ENSP00000262367
    CSHL1Q144063, ENSP000003095244I2D: score=1 STRING: ENSP00000309524
    MAML1Q925853, ENSP000002925994I2D: score=1 STRING: ENSP00000292599
    NOTCH2Q047213, ENSP000002566464I2D: score=1 STRING: ENSP00000256646
    NOTCH3Q9UM473, ENSP000002633884I2D: score=1 STRING: ENSP00000263388
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0007219Notch signaling pathway TAS--
    GO:0010467gene expression TAS--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA12370315


    MAML2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MAML2 gene: 
    NM_032427.1  

    Unigene Cluster for MAML2:

    Mastermind-like 2 (Drosophila)
    Hs.428214  [show with all ESTs]
    Unigene Representative Sequence: CR627398
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524717(uc001pfw.1) ENST00000440572

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    Additional cDNA sequence: 

    AB058722.1 AK308157.1 AY040322.1 AY186997.1 BC143529.1 BC152449.1 CR627398.1 DQ084494.1 
    DQ886023.1 DQ886024.1 

    6 DOTS entries:

    DT.86837777  DT.105402  DT.100017295  DT.120741795  DT.97822430  DT.40212270 

    24/63 AceView cDNA sequences (see all 63):

    NM_032427 BQ219346 AW439287 BQ435054 CA436800 BX476471 CR610618 CR627398 
    BM992400 BM975425 BI860842 CK823639 BU193970 AI126293 AL602311 AB058722 
    AA598550 AI769569 BF196771 BG623583 AI480151 AL701122 AL602409 BQ129427 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MAML2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MAML2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MAML2

    SOURCE GeneReport for Unigene cluster: Hs.428214

    UniProtKB/Swiss-Prot: MAML2_HUMAN, Q8IZL2
    Tissue specificity: Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including MAML2: 
              Notch Signaling Pathway in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MAML2 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves MAML21 mastermind-like 2 (Drosophila) 72.08(n)
    67.25(a)
      428088  XM_003640590.1  XP_003640638.1 
    lizard
    (Anolis carolinensis)
    Reptilia MAML26
    --
    56(a)
    1 ↔ 1
    3(195204179-195283159)
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01023960.16
    --
    30(a)
    1 ↔ 1
    15(3757398-3773823)


    ENSEMBL Gene Tree for MAML2 (if available)
    TreeFam Gene Tree for MAML2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MAML2 gene
    MAML32  MAMLD12  MAML12  
    3 SIMAP similar genes for MAML2 using alignment to 2 protein entries:     MAML2_HUMAN (see all proteins):
    MLL/MAML2 fusion    MLL-MAML2    CAGH3

    MAML2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6845 NCBI SNPs in MAML2 are shown (see all 6845    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs5318261,2
    H--92054399(-) CTATTT/GGGCTG 1 -- ds50014Minor allele frequency- G:0.00NS EA 420
    rs5408731,2
    H--92054686(+) TAAATT/GGAGGG 1 -- ds50014Minor allele frequency- G:0.00NS EA 420
    rs773392521,2
    F,--92054904(+) TTCCCC/AAAGTT 1 -- nc-transcript-variant2Minor allele frequency- A:0.05NA EA 240
    rs787507241,2
    C,F,--92055104(+) ACAAAA/GTNNNN 1 -- nc-transcript-variant2Minor allele frequency- G:0.05NA EA 240
    rs110214981,2
    C,F,H,--92056282(+) TCAAAC/TGACCA 1 -- us2k114Minor allele frequency- T:0.12NS EA NA WA CSA 928
    rs356750971,2
    --92057043(+) ACAAAC/TGTTGC 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs116000181,2
    C,F,H,--92057323(+) TATAAA/TTGAAT 1 -- us2k111Minor allele frequency- T:0.15NS EA NA WA CSA 662
    rs789175661,2
    F,--92057482(+) AAAACC/TGAAAA 1 -- us2k12Minor allele frequency- T:0.04NA EA 240
    rs747569261,2
    --92057517(+) TATGCA/GTTGAT 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs71147411,2
    C,F,H,--95710993(+) AATACG/TTCCAA 1 -- ds500121Minor allele frequency- T:0.06NS EA NA CSA 2626

    HapMap Linkage Disequilibrium report for MAML2 (95709762 - 95959762 bp, first 250kb of MAML2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 17 variations for MAML2
         11 CNVs: 61178 0154 71369 43834 85957 75772 5641 5424 58543 48925 101306
         6 Indels: 75773 10685 85956 11572 101305 10684

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MAML2 for disorders           About GeneDecksing

    OMIM gene information: 607537    OMIM disorders: --

    UniProtKB/Swiss-Prot: MAML2_HUMAN, Q8IZL2
  • Note=A chromosomal aberration involving MAML2 is found in mucoepidermoid carcinomas, benign Warthin tumors and
  • clear cell hidradenomas. Translocation t(11;19)(q21;p13) with CRTC1/MECT1. The fusion protein consists of the
    N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of
    MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas

    19 diseases for MAML2:    About MalaCards
    mucoepidermoid salivary gland carcinoma    epithelial-myoepithelial carcinoma    hidradenoma    clear cell hidradenoma
    myoepithelial carcinoma    cutaneous mucoepidermoid carcinoma    adenosquamous carcinoma    lipoadenoma
    cervical adenosquamous carcinoma    warthin tumor    mucoepidermoid carcinoma    acute lymphoblastic leukemia
    lymphoblastic leukemia    hypospadias    myelodysplastic syndrome    carcinoma
    leukemia    cervicitis    thyroiditis

    7 diseases from the University of Copenhagen DISEASES database for MAML2:
    Mucoepidermoid carcinoma     Hidradenoma     Lipoadenoma     epithelial-myoepithelial carcinoma
    Lacrimal gland cancer     Cervical adenosquamous carcinoma     Necrotizing sialometaplasia

    4 Novoseek disease relationships for MAML2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hidradenoma 86.5 2 17334997 (1), 17551948 (1)
    carcinoma mucoepidermoid 72.5 2 16444749 (1), 17334997 (1)
    carcinoma 17.4 1 17551948 (1)
    tumors 11 2 16103063 (1), 17551948 (1)

    Human Genome Epidemiology (HuGE) Navigator: MAML2 (2 documents)

    Export disorders for MAML2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MAML2 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with MAML2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of new human mastermind proteins defines a family that consists of positive regulators for Notch signaling. (PubMed id 12386158)1, 2, 3 Lin S.-E.... Kitagawa M. (2002)
    2. Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. (PubMed id 12370315)1, 2, 3 Wu L.... Griffin J.D. (2002)
    3. Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion. (PubMed id 15729701)1, 2 Behboudi A.... Stenman G. (2005)
    4. Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. (PubMed id 14720503)1, 2 Enlund F....Stenman G. (2004)
    5. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. (PubMed id 12539049)1, 2 Tonon G.... Kaye F.J. (2003)
    6. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
    7. Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23). (PubMed id 17551948)1, 9 Nemoto N....Nagasawa T. (2007)
    8. Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas. (PubMed id 17334997)1, 9 Winnes M....Stenman G. (2007)
    9. Prospective testing of mucoepidermoid carcinoma for th e MAML2 translocation: clinical implications. (PubMed id 22833306)1 Chiosea S.I....Seethala R.R. (2012)
    10. Fluorescence in situ hybridization for detection of M AML2 rearrangements in oncocytic mucoepidermoid carcinomas: utility as a diagno stic test. (PubMed id 21777943)1 GarcA-a J.J....Seethala R.R. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84441 HGNC: 16259 AceView: MAML2 Ensembl:ENSG00000184384 euGenes: HUgn84441
    ECgene: MAML2 Kegg: 84441 H-InvDB: MAML2

    (According to HUGE)
    About This Section
    HUGE: KIAA1819

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MAML2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MAML2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MAML2 gene:
    Search GeneIP for patents involving MAML2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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