Aliases for MAML1 Gene
External Ids for MAML1 Gene
Previous GeneCards Identifiers for MAML1 Gene
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008]
GeneCards Summary for MAML1 Gene
MAML1 (Mastermind Like Transcriptional Coactivator 1) is a Protein Coding gene. Diseases associated with MAML1 include Cerebellum Cancer. Among its related pathways are Signaling by NOTCH1 and NOTCH2 Activation and Transmission of Signal to the Nucleus. GO annotations related to this gene include protein kinase binding and peptide antigen binding. An important paralog of this gene is MAML3.
UniProtKB/Swiss-Prot for MAML1 Gene
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.