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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MAMDC2 Gene

protein-coding GIFtS: 47
GCID: GC09P072658

MAM domain containing 2

Explore 1 disease affiliated with
MAMDC2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
MAM Domain Containing 2¹ ²		MAM Domain-Containing Protein 2²
MAM Domain-Containing Proteoglycan² ³		Mamcan³
MGC21981¹		Mamcan³
MAM Domain Containing 1²

External Ids:	HGNC: 23673¹	Entrez Gene: 256691²	Ensembl: ENSG00000165072⁷	OMIM: 612879⁵	UniProtKB: Q7Z304³

Export aliases for MAMDC2 gene to outside databases

Previous GC identifers: GC09P068115 GC09P069888 GC09P071848 GC09P042498

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MAMDC2 gene promoter:
NF-1 NF-1/L FOXF2 AML1a GCNF HSF1 (long) LCR-F1 GCNF-1 HSF1short Cart-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MAMDC2 promoter sequence

Search SABiosciences Chromatin IP Primers for MAMDC2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAMDC2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.12 Ensembl cytogenetic band: 9q21.12 HGNC cytogenetic band: 9q21.2

MAMDC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MAMDC2 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P072658: view genomic region (about GC identifiers)

Start:	72,658,497 bp from pter	End:	72,841,888 bp from pter
Size:	183,392 bases	Orientation:	plus strand

1 alternative location:

Chr9+,PATCHES 72,655,457-72,788,588

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MAMC2_HUMAN, Q7Z304 (See protein sequence)

Recommended Name: MAM domain-containing protein 2 precursor

Size: 686 amino acids; 77556 Da

Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)

Secondary accessions: Q5VW47 Q8WX43 Q96BM4

Alternative splicing: 2 isoforms: Q7Z304-1 Q7Z304-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MAMDC2: NX_Q7Z304

Post-translational modifications:

O-glycosylated (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q7Z304

MAMDC2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_694999.3

ENSEMBL proteins:

ENSP00000366387

Human Recombinant Protein Products for MAMDC2:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MAMDC2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005614	interstitial matrix	IEA	--
GO:0005783	endoplasmic reticulum	IDA	--
GO:0016020	membrane	IEA	--
GO:0031012	extracellular matrix	--	--

MAMDC2 for ontologies About GeneDecksing

MAMDC2 Antibody Products:

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	Search ThermoFisher Antibodies for MAMDC2

Assay Products for MAMDC2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for MAMDC2
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	Uscn ELISAs and CLIAs for MAMDC2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MAMDC2 for domains About GeneDecksing

2 InterPro domains/families:

IPR000998 MAM_dom

IPR008985 ConA-like_lec_gl_sf

Graphical View of Domain Structure for InterPro Entry Q7Z304

ProtoNet protein and cluster: Q7Z304

1 Blocks protein family: IPB000998 MAM domain signature

UniProtKB/Swiss-Prot: MAMC2_HUMAN, Q7Z304

Similarity: Contains 4 MAM domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005539	glycosaminoglycan binding	IEA	--

MAMDC2 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MAMDC2

miRNA Products:		OriGene 3'-UTR Clone: MAMDC2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAMDC2
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate MAMDC2 (see all 23):
		hsa-miR-217 hsa-miR-607 hsa-miR-125a-5p hsa-miR-429 hsa-miR-181c hsa-miR-16-1* hsa-miR-628-3p hsa-miR-132

		SwitchGear 3'UTR luciferase reporter plasmid: MAMDC2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAMDC2 (see all 4) OriGene shRNA RFP: MAMDC2 OriGene siRNA: MAMDC2
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MAMDC2
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAMDC2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MAMDC2

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan	IEA	--

MAMDC2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MAMDC2
Search CenterWatch for drugs/clinical trials and news about MAMDC2 / MAMC2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MAMDC2 gene:

NM_153267.4

Unigene Cluster for MAMDC2:

MAM domain containing 2

Hs.547172 [show with all ESTs]

Unigene Representative Sequence: BX538309

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000377182(uc004ahm.2 uc004ahn.2) ENST00000460688

miRNA Products:		OriGene 3'-UTR Clone: MAMDC2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MAMDC2
		8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate MAMDC2 (see all 23):
		hsa-miR-217 hsa-miR-607 hsa-miR-125a-5p hsa-miR-429 hsa-miR-181c hsa-miR-16-1* hsa-miR-628-3p hsa-miR-132

		SwitchGear 3'UTR luciferase reporter plasmid: MAMDC2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAMDC2 (see all 4) OriGene shRNA RFP: MAMDC2 OriGene siRNA: MAMDC2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAMDC2
		Sirion Biotech Custom design and validation of potent shRNA sequences against MAMDC2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAMDC2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAMDC2 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MAMDC2 (NM_153267)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MAMDC2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAMDC2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAMDC2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MAMDC2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAMDC2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAMDC2

Additional cDNA sequence:

AK304040.1 AK304531.1 BC015417.2 BC016383.1 BC040299.1 BC045569.1 BC063634.1 BX538309.1

CR456729.1

24/41 DOTS entries (see all 41):

DT.407827 DT.95262453 DT.100704948 DT.87000728 DT.91656907 DT.100059916 DT.120845959 DT.91779030

DT.101986946 DT.100704939 DT.100704946 DT.75119856 DT.120845871 DT.121184404 DT.120845851 DT.300550

DT.85105500 DT.100704936 DT.87000716 DT.100704943 DT.100704945 DT.100704950 DT.97868502 DT.100059913

24/106 AceView cDNA sequences (see all 106):

BQ883306 BM729321 AI754634 BM802901 BX489352 AI890418 BF981324 BQ446119

AA451604 BC063634 NM_153267 BC040299 BG546966 BC016383 BG547454 AI832739

BX952255 AI141976 AI239735 BG109966 AI862120 AA464840 AI270603 CD106817

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for MAMDC2 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13a	·	13b	^	14a	·	14b
SP1:																									-				-
SP2:																									-				-
SP3:																													-
SP4:

ECgene alternative splicing isoforms for MAMDC2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MAMDC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATAGAAATT

About this image

MAMDC2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

N2/LSB induced-cells (Generation of midbra...)

Definitive endoderm-like cells (Generation of mesend...)

Definitive endoderm-like cells (A scalable, suspensi...)

Cardiomyocyte-like cells (Spontaneous differen...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MAMDC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MAMDC2

SOURCE GeneReport for Unigene cluster: Hs.547172

SABiosciences Custom PCR Arrays for MAMDC2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAMDC2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MAMDC2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAMDC2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAMDC2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAMDC2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for MAMDC2 gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MAMDC2¹	MAM domain containing 2	75.71(n) 76.25(a)		427247 XM_003643015.1 XP_003643063.1
lizard (Anolis carolinensis)	Reptilia	MAMDC2⁶	--	73(a)	1 ↔ 1	2(49223424-49249225)
African clawed frog (Xenopus laevis)	Amphibia	geneB-A-prov²	MAM domain protein	75.17(n)		U37376.1
zebrafish (Danio rerio)	Actinopterygii	LOC556154¹	novel protein similar to human and mouse MAM domain more	60.19(n) 56.02(a)		556154 NM_001130397.1 NP_001123869.1
honey bee (Apis mellifera)	Insecta	--	--	8(a)	possible ortholog	GroupUn.320(38529-42048)

ENSEMBL Gene Tree for MAMDC2 (if available)
TreeFam Gene Tree for MAMDC2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MAMDC2 gene

MAMDC4² MDGA2² MDGA1² C10orf112²

1 SIMAP similar gene for MAMDC2 using alignment to 1 protein entry: MAMC2_HUMAN:

NRP1

MAMDC2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs56982239^1,2	C	--	42544960(+)	`GATGT-/CACACAC`	1	--	int¹		1		NA	2
rs57802664^1,2	C	--	42582267(+)	`CCAAG-/TTATTAAT`	1	--	int¹		1		NA	2
rs72709195^1,2	C,F	--	72656649(+)	`TTAGGC/TGGTGA`	1	--	us2k¹		1		NA	120
rs183596020^1,2		--	72656787(+)	`GGTGAC/TTGAAG`	1	--	us2k¹		0	--	--	--	--
rs76101424^1,2	C	--	72656814(+)	`GTGGGG/TCTGGG`	1	--	us2k¹		0	--	--	--	--
rs62572645^1,2		--	72656842(+)	`GTAATC/AGCAGC`	1	--	us2k¹		1		NA	2
rs188247646^1,2		--	72656853(+)	`ACTTCA/GGGAGT`	1	--	us2k¹		0	--	--	--	--
rs2997652^1,2	C,F,H	--	72656879(+)	`CATGAT/GGTCAA`	1	--	us2k¹		9		NA WA CSA EA	371
rs190355002^1,2		--	72656913(+)	`CATGGC/TGAAAC`	1	--	us2k¹		0	--	--	--	--
rs182730763^1,2		--	72656954(+)	`TGGGCA/GTGGTG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MAMDC2 (72658497 - 72841888 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for MAMDC2
5 CNVs: 96103 65419 96104 36964 36963
1 Indel: 83055

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAMDC2

DNA2.0 Custom Variant and Variant Library Synthesis for MAMDC2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MAMDC2 for disorders           About GeneDecksing

OMIM gene information: 612879    OMIM disorders: --

1 disease for MAMDC2:    About MalaCards

keratoconus

Human Genome Epidemiology (HuGE) Navigator: MAMDC2 (1 document)

Export disorders for MAMDC2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MAMDC2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MAMDC2)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
The LIFEdb database in 2006. (PubMed id 16381901)¹ Mehrle A....Wiemann S. (2006)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)¹ Wiemann S....Poustka A. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)¹ Simpson J.C.... Wiemann S. (2000)
DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)¹ Hartley J.L....Brasch M.A. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 256691	HGNC: 23673	AceView: MAMDC2	Ensembl:ENSG00000165072	euGenes: HUgn256691
ECgene: MAMDC2	H-InvDB: MAMDC2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MAMDC2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MAMDC2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MAMDC2 gene:
Search GeneIP for patents involving MAMDC2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	EMD Millipore Custom Antibody & Bulk Services
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	Browse OriGene Antibodies		OriGene shRNA RFP for MAMDC2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MAMDC2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MAMDC2
	OriGene Protein Over-expression Lysate for MAMDC2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for MAMDC2		OriGene 3'-UTR Clone for MAMDC2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MAMDC2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MAMDC2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for MAMDC2		OriGene Custom Protein Services for MAMDC2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MAMDC2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MAMDC2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MAMDC2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MAMDC2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MAMDC2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MAMDC2

	GenScript Custom Purified and Recombinant Proteins Services for MAMDC2		GenScript cDNA clones with any tag delivered in your preferred vector for MAMDC2
	GenScript Custom Assay Services for MAMDC2		GenScript Custom Superior Antibodies Services for MAMDC2
	GenScript Custom overexpressing Cell Line Services for MAMDC2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in MAMDC2 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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	Antibodies for MAMDC2
	See all of Abcam's Antibodies, Kits and Proteins for MAMDC2
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Browse ProSpec Recombinant Proteins

MAMDC2 Proteins, Antibodies, CLIAs, and ELISAs

Cell Line associated with MAMDC2: PureStem ES-210, Ecto-ntu Progenitor

	Gene Synthesis
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	Codon Optimization
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MAMDC2

	SwitchGear 3'UTR luciferase reporter plasmids for MAMDC2
	SwitchGear Promoter luciferase reporter plasmids for MAMDC2

Search ThermoFisher Antibodies for MAMDC2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MAMDC2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MAMDC2

Sirion Biotech Customized:

	stable knockdown cell line services for MAMDC2
	inducible knockdown cell line services for MAMDC2
	design and validation of potent shRNA sequences against MAMDC2
	adenovirus for potent knockdown of MAMDC2
	adenovirus for overexpression of MAMDC2
	stable overexpressing cell line services for MAMDC2
	inducible overexpressing cell line services for MAMDC2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes MAMDC2 gene at Home site.

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MAMDC2 Gene

MAM domain containing 2

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MAMDC2 Gene

MAM domain containing 2

Aliasesfor MAMDC2 gene

Summariesfor MAMDC2 gene

Genomic Viewsfor MAMDC2 gene

Proteinsfor MAMDC2 gene

Protein Domains /Familiesfor MAMDC2 gene

Functionfor MAMDC2 gene

Pathways & Interactionsfor MAMDC2 gene

Drugs & Compoundsfor MAMDC2 gene

Transcriptsfor MAMDC2 gene

Expression for MAMDC2 gene

Orthologsfor MAMDC2 gene

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Genomic Variantsfor MAMDC2 gene

Disorders / Diseasesfor MAMDC2 gene

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External Searches for MAMDC2 gene

Genome Databases showing MAMDC2 gene

Other Databases showing MAMDC2 gene

Specialized Databases showing MAMDC2 gene

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Aliases
for MAMDC2 gene

Summaries
for MAMDC2 gene

Genomic Views
for MAMDC2 gene

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for MAMDC2 gene

Protein Domains /
Families
for MAMDC2 gene

Function
for MAMDC2 gene

Pathways & Interactions
for MAMDC2 gene

Drugs & Compounds
for MAMDC2 gene

Transcripts
for MAMDC2 gene

Expression
for MAMDC2 gene

Orthologs
for MAMDC2 gene

Paralogs
for MAMDC2 gene

Genomic Variants
for MAMDC2 gene

Disorders / Diseases
for MAMDC2 gene

Publications
for MAMDC2 gene

Intellectual Property
for MAMDC2 gene

Products
for MAMDC2 gene