Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MALT1 Gene

protein-coding   GIFtS: 67
GCID: GC18P056339

mucosa associated lymphoid tissue lymphoma translocation...


(Previous symbol: MLT)
 Explore 17 diseases affiliated with
MALT1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MALT1    

Aliases
for MALT1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 11 2     MALT-Lymphoma Associated Translocation2
MLT1 2 3 5     Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 12
MALT Lymphoma-Associated Translocation2 3     Paracaspase3
MLT12     EC 3.4.22.-3
Caspase-Like Protein2     Paracaspase3
MALT Associated Translocation2     

External Ids:    HGNC: 68191   Entrez Gene: 108922   Ensembl: ENSG000001721757   OMIM: 6048605   UniProtKB: Q9UDY83   

Export aliases for MALT1 gene to outside databases

Previous GC identifers: GC18P056267 GC18P056123 GC18P054487 GC18P054489 GC18P053046


Summaries
for MALT1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MALT1:
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral
IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in
mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation.
Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. (provided
by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: MALT1_HUMAN, Q9UDY8
Function: Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6,
inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent
BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion

Gene Wiki entry for MALT1


Genomic Views
for MALT1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NC_018929.1  NT_025028.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MALT1 gene promoter:
         ATF-2   MEF-2   Olf-1   c-Ets-1   GATA-1   MEF-2A   POU2F1   POU2F1a   aMEF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MALT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for MALT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MALT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21   Ensembl cytogenetic band:  18q21.32   HGNC cytogenetic band: 18q21

MALT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MALT1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P056339:  view genomic region     (about GC identifiers)

Start:
 56,338,618 bp from pter      End:
 56,417,371 bp from pter
Size:
 78,754 bases      Orientation:
 plus strand

Proteins
for MALT1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: MALT1_HUMAN, Q9UDY8 (See protein sequence)
Recommended Name: Mucosa-associated lymphoid tissue lymphoma translocation protein 1  
Size: 824 amino acids; 92272 Da
Subunit: Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6
Subcellular location: Cytoplasm, perinuclear region. Nucleus. Note=Shuttles between the nucleus and cytoplasm. Found in
perinuclear structures together with BCL10
6/7 PDB 3D structures from and Proteopedia for MALT1 (see all 7):
2G7R (3D)        3BFO (3D)        3K0W (3D)        3UO8 (3D)        3UOA (3D)        3V4O (3D)    
Secondary accessions: Q9NTB7 Q9ULX4
Alternative splicing: 2 isoforms:  Q9UDY8-1   Q9UDY8-2   

Explore the universe of human proteins at neXtProt for MALT1: NX_Q9UDY8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UDY8

    • MALT1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_006776.1  NP_776216.1  

    ENSEMBL proteins: 
     ENSP00000319279   ENSP00000304161   ENSP00000467222  
    Reactome Protein details: Q9UDY8
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MALT1
    OriGene Protein Over-expression Lysate (see all 2): MALT1
    OriGene Custom Protein Services for MALT1 
    GenScript Custom Purified and Recombinant Proteins Services for MALT1
    Novus Biologicals MALT1 Proteins
    Novus Biologicals MALT1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MALT1

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--


    MALT1 for ontologies           About GeneDecksing



    MALT1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of MALT1
    R&D Systems Antibodies for MALT1
    Cell Signaling Technology (CST) Antibodies for MALT1 
    OriGene Antibodies (see all 3): MALT1
    OriGene Custom Antibody Services for MALT1 
    GenScript Custom Superior Antibodies Services for MALT1
    Novus Biologicals MALT1 Antibodies
    Abcam antibodies for MALT1 
    Uscn Antibodies for MALT1
    ThermoFisher Antibodies for MALT1

    Assay Products for MALT1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MALT1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MALT1

    Protein Domains /
    Families
    for MALT1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MALT1 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR003598 Ig_sub2
     IPR001309 Pept_C14_ICE_p20
     IPR011029 DEATH-like_dom
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UDY8

    ProtoNet protein and cluster: Q9UDY8

    2 Blocks protein families:
    IPB001309 Caspase-1
    IPB003598 Immunoglobulin C-2 type


    UniProtKB/Swiss-Prot: MALT1_HUMAN, Q9UDY8
    Similarity: Belongs to the peptidase C14B family
    Similarity: Contains 1 death domain
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    Function
    for MALT1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: MALT1_HUMAN, Q9UDY8
    Function: Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6,
    inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent
    BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion

         Genatlas biochemistry entry for MALT1:
    mucosa associated lymphoid tissue rearranged with API2 in the t(11;18)(q21;q21) in extranodal marginal zone B-cell
    lymphomas,in low-grade B cell lymphoma of mucosa associated lymphoid tissue

    Enzyme Number (IUBMB): EC 3.4.22.-1

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): MALT1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MALT1
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate MALT1 (see all 20):
    hsa-miR-142-3p hsa-miR-607 hsa-miR-300 hsa-miR-578 hsa-miR-759 hsa-miR-371-5p hsa-miR-373* hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmid: MALT1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MALT1 (see all 4)
    OriGene shRNA RFP: MALT1
    OriGene siRNA: MALT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MALT1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for MALT1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MALT1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MALT1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MALT1 (NM_006785)
    Sino Biological Human cDNA Clone for MALT1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MALT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MALT1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for MALT1
    Search LifeMap BioReagents cell lines for MALT1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MALT1

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IEA--
    GO:0004197cysteine-type endopeptidase activity NAS11090634
    GO:0004842ubiquitin-protein ligase activity IDA15125833
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI18223652


    MALT1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MALT1:
     Decreased telomerase activity 

    Animal Models:
         Mouse knock-outs for MALT1: Malt1tm1Jrld Malt1tm1Vmd
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Malt1):
     cellular  hematopoietic system  immune system 

    MALT1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for MALT1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1B cell receptor signaling pathway
    		B cell receptor signaling pathway1.00
    		PI3K Signaling in B-Lymphocyte0.35
    		BCR signaling pathway0.41
    		TCR Signaling Pathway0.19
    		T cell receptor signaling pathway0.40
    2Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    3TCR signaling
    		TCR signaling1.00
    		Downstream TCR signaling0.75
    4Signaling by the B Cell Receptor (BCR)
    		Signaling by the B Cell Receptor (BCR)1.00
    		Downstream Signaling Events Of B Cell Receptor (BCR)0.81
    5Immune response T cell receptor signaling pathway
    		Immune response T cell receptor signaling pathway1.00
    		Immune response_T cell receptor signaling pathway0.88

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for MALT1
        Immune response T cell receptor signaling pathway

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for MALT1
        PI3K Signaling in B-Lymphocyte
    PKC-Theta Pathway
    TCR Signaling
    CD28 Signaling in T-Helper Cell
    NF-KappaB Family Pathway

    3 Cell Signaling Technology (CST) Pathways for MALT1
        Apoptosis and Autophagy
    Lymphocyte Signaling
    NF-kappaB Signaling

    1 GeneGo (Thomson Reuters) Pathway for MALT1
        Immune response T cell receptor signaling pathway

    5 BioSystems Pathways for MALT1 
        TCR Signaling Pathway
    BCR signaling pathway
    TCR signaling in naive CD8+ T cells
    TCR signaling in naive CD4+ T cells
    Canonical NF-kappaB pathway

    5/9        Reactome Pathways for MALT1 (see all 9)
        Adaptive Immune System
    Activation of NF-kappaB in B Cells
    Signaling by the B Cell Receptor (BCR)
    Downstream TCR signaling
    Downstream Signaling Events Of B Cell Receptor (BCR)


    3         Kegg Pathways  (Kegg details for MALT1):
        T cell receptor signaling pathway
    B cell receptor signaling pathway
    Tuberculosis


    MALT1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MALT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/35 Interacting proteins for MALT1 (Q9UDY81, 2, 3 ENSP000003192794) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CARD11Q9BXL72, 3, ENSP000003801504MINT-6177529 MINT-6177640 MINT-8143041 I2D: score=1 STRING: ENSP00000380150
    TRAF6Q9Y4K32, 3MINT-6177590 MINT-6177582 MINT-6177625 I2D: score=7 
    SQSTM1Q135012, 3, ENSP000003744554MINT-2844299 MINT-2844278 I2D: score=3 STRING: ENSP00000374455
    MAP3K7O433182, 3, ENSP000003583354MINT-6177574 I2D: score=3 STRING: ENSP00000358335
    COPS5Q929052, 3, ENSP000003505124MINT-7228546 I2D: score=2 STRING: ENSP00000350512
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001923B-1 B cell differentiation IEA--
    GO:0002237response to molecule of bacterial origin IEA--
    GO:0002726positive regulation of T cell cytokine production IMP15125833
    GO:0006508proteolysis IDA18223652
    GO:0006952defense response NAS10523859


    MALT1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MALT1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    MALT1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for MALT1

    Browse Tocris compounds for MALT1
    4 Novoseek chemical compound relationships for MALT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    guanylate 31.5 4 15598810 (1), 19714753 (1)
    paraffin 13.4 1 19094584 (1)
    lipid 0 6 14754896 (2), 15598810 (1), 15541657 (1)
    cysteine 0 1 17967946 (1)

    Search CenterWatch for drugs/clinical trials and news about MALT1 

    Transcripts
    for MALT1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MALT1 gene (2 alternative transcripts): 
    NM_006785.2  NM_173844.1  

    Unigene Cluster for MALT1:

    Mucosa associated lymphoid tissue lymphoma translocation gene 1
    Hs.601217  [show with all ESTs]
    Unigene Representative Sequence: NM_006785
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000348428(uc002lhm.1 uc002lhn.1) ENST00000345724 ENST00000591792
    ENST00000589873 ENST00000587438

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): MALT1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MALT1
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate MALT1 (see all 20):
    hsa-miR-142-3p hsa-miR-607 hsa-miR-300 hsa-miR-578 hsa-miR-759 hsa-miR-371-5p hsa-miR-373* hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmid: MALT1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MALT1 (see all 4)
    OriGene shRNA RFP: MALT1
    OriGene siRNA: MALT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MALT1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MALT1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MALT1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): MALT1 (NM_006785)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MALT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MALT1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MALT1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MALT1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MALT1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MALT1

    Additional cDNA sequence: 

    AB026118.1 AF070528.1 AF130356.2 AF316597.1 AK024859.1 AK291386.1 AL137399.1 BC030143.2 

    8 DOTS entries:

    DT.95378868  DT.409881  DT.95378865  DT.100022175  DT.102830301  DT.408942  DT.455907  DT.99949626 

    24/132 AceView cDNA sequences (see all 132):

    CF141435 BX103691 AI373337 AL599422 AK092004 NM_006785 AA706088 AB026118 
    AA767835 AA281201 AA781565 AI685199 AF316597 BC030143 CR601027 BQ130948 
    BU685883 BM724275 BM055371 BQ006885 CA413217 BU164882 AW292944 AW999949 

    GeneLoc Exon Structure


    Expression
    for MALT1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MALT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGATAGACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    MALT1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    EyeRetinaEye
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MALT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MALT1

    SOURCE GeneReport for Unigene cluster: Hs.601217

    UniProtKB/Swiss-Prot: MALT1_HUMAN, Q9UDY8
    Tissue specificity: Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow,
    thymus and lymph node, and at very low levels in colon and lung

        SABiosciences Expression via Pathway-Focused PCR Arrays including MALT1: 
              NFKB Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Antifungal Response in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MALT1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MALT1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MALT1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MALT1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MALT1

    Orthologs
    for MALT1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MALT1 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Malt11 , 5 mucosa associated lymphoid tissue lymphoma translocation more1, 5 86.15(n)1
    88.29(a)1    		   18 (38.56 cM)5
    2403541  NM_172833.21  NP_766421.11 
     654309635 
    chicken
    (Gallus gallus)    		 Aves LOC4268521 mucosa-associated lymphoid tissue lymphoma translocation more 72.14(n)
    70.65(a)    		   426852  XM_003642904.1  XP_003642952.1 
    lizard
    (Anolis carolinensis)    		 Reptilia MALT16
    		 --
    		 60(a)
    		 1 ↔ 1
    		 GL343213.1(2789643-2832854)
    zebrafish
    (Danio rerio)    		 Actinopterygii malt12 mucosa associated lymphoid tissue lymphoma translocation more 74.36(n)   259196  AF316598.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea F22D3.61 , 3 Protein F22D3.61 26(a)3
    46.95(n)1
    30.91(a)1    		   II(6947908-6951232)3
    1741351  NM_063023.51  NP_495424.21 


    ENSEMBL Gene Tree for MALT1 (if available)
    TreeFam Gene Tree for MALT1 (if available) 

    Paralogs
    for MALT1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for MALT1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1293 NCBI SNPs in MALT1 are shown (see all 1293)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 18 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1117145661,2
    		--56336911(+) AAAAAG/TACCAG 2 -- us2k12Minor allele frequency- T:0.06CSA WA 120
    rs1830530041,2
    		--56336926(+) AAAAGG/TTAATG 2 -- us2k10--------
    rs1131459911,2
    		C,--56336955(+) GGAGGG/ATGGCG 2 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1388347401,2
    		--56337096(+) GAGCTA/GTATTG 2 -- us2k10--------
    rs1493746311,2
    		--56337211(+) GAAGAC/TCTCTG 2 -- us2k10--------
    rs124585371,2
    		C,F,H,--56337296(+) ACAGAT/GCCTCA 2 -- us2k123Minor allele frequency- G:0.15NS EA NA WA CSA 2777
    rs129636571,2
    		C,F,A,--56337350(+) TGAAGC/TGGTTG 2 -- us2k14Minor allele frequency- T:0.04NA 126
    rs1447103991,2
    		--56337351(+) GAAGCA/GGTTGG 2 -- us2k10--------
    rs75059261,2
    		C,F,--56337598(+) TCATGC/ATCTTA 2 -- us2k19Minor allele frequency- A:0.15NA WA CSA EA 369
    rs49404181,2
    		F,--56337602(+) GCTCTT/CAGCCA 2 -- us2k12Minor allele frequency- C:0.07NA EA 240

    HapMap Linkage Disequilibrium report for MALT1 (56338618 - 56417371 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for MALT1
         4 CNVs: 50015 102683 58842 58841

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MALT1
    DNA2.0 Custom Variant and Variant Library Synthesis for MALT1

    Disorders / Diseases
    for MALT1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MALT1 for disorders           About GeneDecksing

    OMIM gene information: 604860    OMIM disorders: --

    UniProtKB/Swiss-Prot: MALT1_HUMAN, Q9UDY8
  • Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue
    • (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of
    cytogenetically abnormal low-grade MALT lymphoma

    17 diseases for MALT1:    About MalaCards
    malt lymphoma    marginal zone b-cell lymphoma    splenic marginal zone lymphoma    b-cell non-hodgkin lymphoma
    diffuse large b-cell lymphoma    non-hodgkin lymphoma    b-cell lymphomas    central nervous system lymphoma
    ovarian sex cord tumors    hodgkin's lymphoma    mantle cell lymphoma    edwards syndrome
    cryoglobulinemia    sjogren's syndrome    colorectal cancer    tuberculosis
    carcinoma

    5 diseases from the University of Copenhagen DISEASES database for MALT1:
    Lymphoma     Edwards syndrome     Gallbladder lymphoma     Gastric lymphoma
    Lung lymphoma

    10 Novoseek disease relationships for MALT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malt lymphoma 93.9 98 15682443 (8), 14760068 (4), 10523859 (3), 11090634 (3) (see all 46)
    lymphoma b-cell 79.9 31 18367485 (4), 14652825 (3), 11066071 (2), 15377491 (2) (see all 19)
    lymphoma 71.9 15 19394813 (2), 11066071 (1), 12560219 (1), 10702396 (1) (see all 10)
    chromosomal aberrations 61.7 10 19080537 (2), 14760068 (2), 16194887 (1), 10702396 (1) (see all 7)
    trisomy 58.7 11 15047736 (3), 18974375 (1), 20305621 (1), 18234275 (1) (see all 6)
    lymphoma non-hodgkins 39.1 3 12560219 (2), 15598810 (1)
    tumors 15.9 9 19738055 (2), 12647364 (1), 14754896 (1), 19897720 (1) (see all 5)
    necrosis 0 1 14754896 (1)
    metastasis 0 1 15067352 (1)
    cancer 0 1 19841088 (1)

    Human Genome Epidemiology (HuGE) Navigator: MALT1 (1 document)

    Export disorders for MALT1 gene to outside databases

    Publications
    for MALT1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MALT1 gene, integrated from 9 sources (see all 173):
    (articles sorted by number of sources associating them with MALT1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas. (PubMed id 10339464)1, 2, 3, 9 Dierlamm J.... Marynen P. (1999)
    2. A novel gene, MALT1 at 18q21, is involved in t(11;18)(q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. (PubMed id 10523859)1, 2, 3, 9 Akagi T.... Seto M. (1999)
    3. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. (PubMed id 15125833)1, 2, 9 Sun L.... Chen Z.J. (2004)
    4. MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10. (PubMed id 16123224)1, 2, 9 Nakagawa M.... Seto M. (2005)
    5. Identification of paracaspases and metacaspases. Two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. (PubMed id 11090634)1, 2, 9 Uren A.G.... Dixit V.M. (2000)
    6. Bcl10 and MALT1, independent targets of chromosomal translocation in MALT lymphoma, cooperate in a novel NF-kappa B signaling pathway. (PubMed id 11262391)1, 2, 9 Lucas P.C.... Nunez G. (2001)
    7. API2-MALT1 chimeric transcripts involved in mucosa-associated lymphoid tissue type lymphoma predict heterogeneous products. (PubMed id 10702396)1, 2, 9 Motegi M.... Seto M. (2000)
    8. Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. (PubMed id 14695475)1, 2 Zhou H.... Dixit V.M. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. API1-MALT1-MLT is involved in mucosa-associated lymphoid tissue lymphoma with t(11;18).(q21;q21). (PubMed id 10610122)1, 2 Suzuki H.... Seto M. (1999)

    External Searches for MALT1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing MALT1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10892 HGNC: 6819 AceView: MALT1 Ensembl:ENSG00000172175 euGenes: HUgn10892
    ECgene: MALT1 Kegg: 10892 H-InvDB: MALT1

    Other Databases showing MALT1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing MALT1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MALT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MALT1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for MALT1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for MALT1 gene:
    Search GeneIP for patents involving MALT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for MALT1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of MALT1
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for MALT1 (MALT1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for MALT1   OriGene shRNA RFP for MALT1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MALT1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MALT1  
     OriGene Protein Over-expression Lysate for MALT1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for MALT1   OriGene 3'-UTR Clone for MALT1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MALT1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MALT1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for MALT1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MALT1   OriGene Custom Protein Services for MALT1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MALT1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MALT1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MALT1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MALT1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MALT1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MALT1
     GenScript Custom Purified and Recombinant Proteins Services for MALT1 GenScript cDNA clones with any tag delivered in your preferred vector for MALT1
     GenScript Custom Assay Services for MALT1 GenScript Custom Superior Antibodies Services for MALT1
     GenScript Custom overexpressing Cell Line Services for MALT1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for MALT1 

     Regulatory tfbs in MALT1 promoter
     Search Chromatin IP Primers for MALT1
     RT2 qPCR Primer Assay in human, mouse, rat MALT1
     GNC Network for MALT1
     SABiosciences PCR Arrays including human, mouse, rat MALT1
     Search Tocris compounds for MALT1
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for MALT1
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Drugs for MALT1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     MALT1 antibodies
     MALT1 proteins
     MALT1 lysates
     Antibodies for MALT1
     See all of Abcam's Antibodies, Kits and Proteins for MALT1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     MALT1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for MALT1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MALT1
     SwitchGear 3'UTR luciferase reporter plasmids for MALT1
     SwitchGear Promoter luciferase reporter plasmids for MALT1
     ThermoFisher Antibodies for MALT1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MALT1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      MALT1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4