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Aliases for MALT1 Gene

Aliases for MALT1 Gene

  • MALT1 Paracaspase 2 3
  • MLT 3 4 6
  • Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 2 3
  • MALT Lymphoma-Associated Translocation 3 4
  • MALT1 Protease 2 3
  • Paracaspase 3 4
  • IMD12 3 6
  • Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 3
  • Caspase-Like Protein 3
  • EC 3.4.22.- 4
  • MLT1 3

External Ids for MALT1 Gene

Previous HGNC Symbols for MALT1 Gene

  • MLT

Previous GeneCards Identifiers for MALT1 Gene

  • GC18P056267
  • GC18P056123
  • GC18P054487
  • GC18P054489
  • GC18P056339
  • GC18P053046

Summaries for MALT1 Gene

Entrez Gene Summary for MALT1 Gene

  • This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MALT1 Gene

MALT1 (MALT1 Paracaspase) is a Protein Coding gene. Diseases associated with MALT1 include immunodeficiency 12 and malt lymphoma. Among its related pathways are PI-3K cascade and Downstream Signaling Events Of B Cell Receptor (BCR). GO annotations related to this gene include ubiquitin-protein transferase activity and peptidase activity.

UniProtKB/Swiss-Prot for MALT1 Gene

  • Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.

Gene Wiki entry for MALT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MALT1 Gene

Genomics for MALT1 Gene

Regulatory Elements for MALT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MALT1 Gene

58,671,386 bp from pter
58,750,139 bp from pter
78,754 bases
Plus strand

Genomic View for MALT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MALT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MALT1 Gene

Proteins for MALT1 Gene

  • Protein details for MALT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mucosa-associated lymphoid tissue lymphoma translocation protein 1
    Protein Accession:
    Secondary Accessions:
    • Q9NTB7
    • Q9ULX4

    Protein attributes for MALT1 Gene

    824 amino acids
    Molecular mass:
    92272 Da
    Quaternary structure:
    • Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6

    Three dimensional structures from OCA and Proteopedia for MALT1 Gene

    Alternative splice isoforms for MALT1 Gene


neXtProt entry for MALT1 Gene

Proteomics data for MALT1 Gene at MOPED

Post-translational modifications for MALT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MALT1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MALT1 (MALT1)

No data available for DME Specific Peptides for MALT1 Gene

Domains for MALT1 Gene

Gene Families for MALT1 Gene

Suggested Antigen Peptide Sequences for MALT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 death domain.
  • Belongs to the peptidase C14B family.
  • Contains 1 death domain.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the peptidase C14B family.
genes like me logo Genes that share domains with MALT1: view

Function for MALT1 Gene

Molecular function for MALT1 Gene

GENATLAS Biochemistry:
mucosa associated lymphoid tissue rearranged with API2 in the t(11;18)(q21;q21) in extranodal marginal zone B-cell lymphomas,in low-grade B cell lymphoma of mucosa associated lymphoid tissue
UniProtKB/Swiss-Prot Function:
Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.

Enzyme Numbers (IUBMB) for MALT1 Gene

Gene Ontology (GO) - Molecular Function for MALT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IEA --
GO:0004197 cysteine-type endopeptidase activity NAS 11090634
GO:0004842 ubiquitin-protein transferase activity IDA 14695475
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 14695475
genes like me logo Genes that share ontologies with MALT1: view

Phenotypes for MALT1 Gene

MGI mutant phenotypes for MALT1:
inferred from 2 alleles
GenomeRNAi human phenotypes for MALT1:
genes like me logo Genes that share phenotypes with MALT1: view

Animal Models for MALT1 Gene

MGI Knock Outs for MALT1:

Animal Model Products

miRNA for MALT1 Gene

miRTarBase miRNAs that target MALT1

No data available for Transcription Factor Targeting and HOMER Transcription for MALT1 Gene

Localization for MALT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MALT1 Gene

Cytoplasm, perinuclear region. Nucleus. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.

Subcellular locations from

Jensen Localization Image for MALT1 Gene COMPARTMENTS Subcellular localization image for MALT1 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 4
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MALT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16123224
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with MALT1: view

Pathways for MALT1 Gene

genes like me logo Genes that share pathways with MALT1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for MALT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001923 B-1 B cell differentiation IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002237 response to molecule of bacterial origin IEA --
GO:0002726 positive regulation of T cell cytokine production IMP 15125833
GO:0006508 proteolysis IDA 18223652
genes like me logo Genes that share ontologies with MALT1: view

Compounds for MALT1 Gene

(4) Novoseek inferred chemical compound relationships for MALT1 Gene

Compound -log(P) Hits PubMed IDs
guanylate 31.5 2
paraffin 13.4 1
lipid 0 4
cysteine 0 1
genes like me logo Genes that share compounds with MALT1: view

Transcripts for MALT1 Gene

Unigene Clusters for MALT1 Gene

Mucosa associated lymphoid tissue lymphoma translocation gene 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MALT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MALT1 Gene

No ASD Table

Relevant External Links for MALT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MALT1 Gene

mRNA expression in normal human tissues for MALT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MALT1 Gene

This gene is overexpressed in Lymph node (15.8), Breast (14.1), Blymphocyte (8.2), Peripheral blood mononuclear cells (7.6), and Lung (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MALT1 Gene

SOURCE GeneReport for Unigene cluster for MALT1 Gene Hs.601217

mRNA Expression by UniProt/SwissProt for MALT1 Gene

Tissue specificity: Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung
genes like me logo Genes that share expressions with MALT1: view

Expression partners for MALT1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MALT1 Gene

Orthologs for MALT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MALT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MALT1 35
  • 86.37 (n)
  • 89.93 (a)
MALT1 36
  • 89 (a)
(Canis familiaris)
Mammalia MALT1 35
  • 88.43 (n)
  • 92.73 (a)
MALT1 36
  • 92 (a)
(Mus musculus)
Mammalia Malt1 35
  • 86.15 (n)
  • 88.29 (a)
Malt1 16
Malt1 36
  • 87 (a)
(Pan troglodytes)
Mammalia MALT1 35
  • 99.72 (n)
  • 99.51 (a)
MALT1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Malt1 35
  • 84.91 (n)
  • 88.81 (a)
(Monodelphis domestica)
Mammalia MALT1 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
-- 36
  • 84 (a)
-- 36
  • 64 (a)
(Gallus gallus)
Aves LOC426852 35
  • 71.73 (n)
  • 70.62 (a)
MALT1 36
  • 63 (a)
(Anolis carolinensis)
Reptilia MALT1 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia malt1 35
  • 64.1 (n)
  • 64.06 (a)
(Danio rerio)
Actinopterygii malt1 35
malt1b 35
  • 61.1 (n)
  • 59.07 (a)
malt1b 36
  • 52 (a)
(Caenorhabditis elegans)
Secernentea F22D3.6 37
  • 26 (a)
F22D3.6 35
  • 46.9 (n)
  • 30.84 (a)
F22D3.6 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1584 36
  • 24 (a)
Species with no ortholog for MALT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MALT1 Gene

Gene Tree for MALT1 (if available)
Gene Tree for MALT1 (if available)

Paralogs for MALT1 Gene

No data available for Paralogs for MALT1 Gene

Variants for MALT1 Gene

Sequence variations from dbSNP and Humsavar for MALT1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs1059442 -- 58,749,461(+) TGCCA(C/T)TTCCA utr-variant-3-prime
rs2319974 -- 58,749,237(-) ACATA(C/T)ACACA utr-variant-3-prime
rs4245275 -- 58,718,206(+) GCCTC(C/T)GTTAG intron-variant
rs4293479 -- 58,709,704(+) TTCAT(A/G)TTAAC intron-variant
rs4293480 -- 58,709,768(+) TGTCA(A/G)ATAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MALT1 Gene

Variant ID Type Subtype PubMed ID
esv2447858 CNV Deletion 19546169
nsv819829 CNV Loss 19587683
nsv519742 CNV Loss 19592680
nsv820257 CNV Loss 19587683
nsv524760 CNV Loss 19592680

Relevant External Links for MALT1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MALT1 Gene

Disorders for MALT1 Gene

(1) OMIM Diseases for MALT1 Gene (604860)


  • Immunodeficiency 12 (IMD12) [MIM:615468]: A primary immunodeficiency characterized by onset in infancy of recurrent bacterial and candidal infections resulting in bronchiectasis and growth delay. Manifestations include mastoiditis, aphthous ulcers, cheilitis, gingivitis, esophagitis, gastritis, duodenitis, and meningitis. Levels of absolute lymphocytes and serum immunoglobulins are normal, but specific antibody titers are low despite immunization, and T-cells show impaired proliferative responses to mitogens. {ECO:0000269 PubMed:23727036}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.

(5) University of Copenhagen DISEASES for MALT1 Gene

(10) Novoseek inferred disease relationships for MALT1 Gene

Disease -log(P) Hits PubMed IDs
malt lymphoma 93.9 69
lymphoma b-cell 79.9 27
lymphoma 71.9 11
chromosomal aberrations 61.7 9
trisomy 58.7 8

Relevant External Links for MALT1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MALT1: view

No data available for Genatlas for MALT1 Gene

Publications for MALT1 Gene

  1. The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas. (PMID: 10339464) Dierlamm J. … Marynen P. (Blood 1999) 2 3 4 23
  2. A novel gene, MALT1 at 18q21, is involved in t(11;18)(q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. (PMID: 10523859) Akagi T. … Seto M. (Oncogene 1999) 2 3 4 23
  3. Identification of paracaspases and metacaspases. Two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. (PMID: 11090634) Uren A.G. … Dixit V.M. (Mol. Cell 2000) 3 4 23
  4. API2-MALT1 chimeric transcripts involved in mucosa-associated lymphoid tissue type lymphoma predict heterogeneous products. (PMID: 10702396) Motegi M. … Seto M. (Am. J. Pathol. 2000) 3 4 23
  5. Bcl10 and MALT1, independent targets of chromosomal translocation in MALT lymphoma, cooperate in a novel NF-kappa B signaling pathway. (PMID: 11262391) Lucas P.C. … Nunez G. (J. Biol. Chem. 2001) 3 4 23

Products for MALT1 Gene

  • Addgene plasmids for MALT1

Sources for MALT1 Gene

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