Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MALT1 Gene

Aliases for MALT1 Gene

  • MALT1 Paracaspase 2 3 5
  • Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 2 3
  • MALT Lymphoma-Associated Translocation 3 4
  • MALT1 Protease 2 3
  • Paracaspase 3 4
  • MLT 3 4
  • Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 3
  • Caspase-Like Protein 3
  • Paracaspase 1 2
  • Paracaspase-1 3
  • EC 3.4.22.- 4
  • PCASP1 3
  • IMD12 3
  • Mlt1 3

External Ids for MALT1 Gene

Previous HGNC Symbols for MALT1 Gene

  • MLT

Previous GeneCards Identifiers for MALT1 Gene

  • GC18P056267
  • GC18P056123
  • GC18P054487
  • GC18P054489
  • GC18P056339
  • GC18P053046

Summaries for MALT1 Gene

Entrez Gene Summary for MALT1 Gene

  • This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MALT1 Gene

MALT1 (MALT1 Paracaspase) is a Protein Coding gene. Diseases associated with MALT1 include Immunodeficiency 12 and Lymphoma, Malt, Somatic. Among its related pathways are RET signaling and Immune response NFAT in immune response. GO annotations related to this gene include ubiquitin-protein transferase activity and peptidase activity.

UniProtKB/Swiss-Prot for MALT1 Gene

  • Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.

Tocris Summary for MALT1 Gene

  • Aminopeptidases catalyze the removal of amino acids from the amino terminus of proteins and peptides. They express different substrate specificities - for example, leucyl aminopeptidase preferentially cleaves leucine residues.

Gene Wiki entry for MALT1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MALT1 Gene

Genomics for MALT1 Gene

Regulatory Elements for MALT1 Gene

Enhancers for MALT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F058727 0.5 FANTOM5 26 +56.1 56147 0.4 ZNF362 ZNF384 MALT1 ENSG00000252284 ENSG00000199713 GC18P058753 MRPL37P1
GH18F058564 1.4 FANTOM5 Ensembl ENCODE 21.3 -106.1 -106086 1.4 EBF1 TBX21 ZBTB40 EP300 RAD51 ZNF366 ZNF512 IKZF1 ETV6 CREM MALT1 ENSG00000252284 ALPK2 LOC105372145
GH18F058653 0.8 FANTOM5 19.5 -17.9 -17913 0.2 TBP MTA2 EBF1 RELA RAD51 IKZF1 TARDBP NBN MLLT1 MALT1 GC18P058645 LOC102724745
GH18F058713 1 Ensembl ENCODE 19.3 +43.0 42970 1.5 PKNOX1 MALT1 ENSG00000252284 MRPL37P1 GC18P058753
GH18F058754 1 Ensembl ENCODE 18.7 +84.0 83970 2.1 POLR2A IKZF1 MALT1 ENSG00000252284 ENSG00000199713 ENSG00000267501 ENSG00000267705
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MALT1 on UCSC Golden Path with GeneCards custom track

Promoters for MALT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001515679 614 2401 ZFP64 ARID4B SIN3A GLIS2 ZNF207 ZNF263 SP3 SP5 PPARG GLIS1

Genomic Location for MALT1 Gene

58,671,386 bp from pter
58,754,477 bp from pter
83,092 bases
Plus strand

Genomic View for MALT1 Gene

Genes around MALT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MALT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MALT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MALT1 Gene

Proteins for MALT1 Gene

  • Protein details for MALT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mucosa-associated lymphoid tissue lymphoma translocation protein 1
    Protein Accession:
    Secondary Accessions:
    • Q9NTB7
    • Q9ULX4

    Protein attributes for MALT1 Gene

    824 amino acids
    Molecular mass:
    92272 Da
    Quaternary structure:
    • Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6.

    Three dimensional structures from OCA and Proteopedia for MALT1 Gene

    Alternative splice isoforms for MALT1 Gene


neXtProt entry for MALT1 Gene

Post-translational modifications for MALT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MALT1 Gene

No data available for DME Specific Peptides for MALT1 Gene

Domains & Families for MALT1 Gene

Gene Families for MALT1 Gene

Suggested Antigen Peptide Sequences for MALT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 death domain.
  • Belongs to the peptidase C14B family.
  • Contains 1 death domain.
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the peptidase C14B family.
genes like me logo Genes that share domains with MALT1: view

Function for MALT1 Gene

Molecular function for MALT1 Gene

GENATLAS Biochemistry:
mucosa associated lymphoid tissue rearranged with API2 in the t(11;18)(q21;q21) in extranodal marginal zone B-cell lymphomas,in low-grade B cell lymphoma of mucosa associated lymphoid tissue
UniProtKB/Swiss-Prot Function:
Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.

Enzyme Numbers (IUBMB) for MALT1 Gene

Gene Ontology (GO) - Molecular Function for MALT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IEA --
GO:0004197 cysteine-type endopeptidase activity IEA,NAS 11090634
GO:0004842 ubiquitin-protein transferase activity IDA 14695475
GO:0004871 signal transducer activity IMP 12761501
GO:0005515 protein binding IPI 14695475
genes like me logo Genes that share ontologies with MALT1: view
genes like me logo Genes that share phenotypes with MALT1: view

Human Phenotype Ontology for MALT1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MALT1 Gene

MGI Knock Outs for MALT1:

Animal Model Products

  • Taconic Biosciences Mouse Models for MALT1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MALT1

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for MALT1 Gene

Localization for MALT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MALT1 Gene

Cytoplasm, perinuclear region. Nucleus. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.

Subcellular locations from

Jensen Localization Image for MALT1 Gene COMPARTMENTS Subcellular localization image for MALT1 gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 5
extracellular 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MALT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 16123224
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA 16123224
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with MALT1: view

Pathways & Interactions for MALT1 Gene

genes like me logo Genes that share pathways with MALT1: view

SIGNOR curated interactions for MALT1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MALT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001923 B-1 B cell differentiation IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002237 response to molecule of bacterial origin IEA --
GO:0002726 positive regulation of T cell cytokine production IMP 15125833
GO:0006508 proteolysis IEA,IDA 18223652
genes like me logo Genes that share ontologies with MALT1: view

Drugs & Compounds for MALT1 Gene

(1) Drugs for MALT1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for MALT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MALT1: view

Transcripts for MALT1 Gene

Unigene Clusters for MALT1 Gene

Mucosa associated lymphoid tissue lymphoma translocation gene 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MALT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MALT1 Gene

No ASD Table

Relevant External Links for MALT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MALT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MALT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MALT1 Gene

This gene is overexpressed in Lymph node (15.8), Breast (14.1), Blymphocyte (8.2), Peripheral blood mononuclear cells (7.6), and Lung (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MALT1 Gene

Protein tissue co-expression partners for MALT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MALT1 Gene:


SOURCE GeneReport for Unigene cluster for MALT1 Gene:


mRNA Expression by UniProt/SwissProt for MALT1 Gene:

Tissue specificity: Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.
genes like me logo Genes that share expression patterns with MALT1: view

Primer Products

No data available for mRNA differential expression in normal tissues for MALT1 Gene

Orthologs for MALT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MALT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MALT1 34 35
  • 99.72 (n)
(Canis familiaris)
Mammalia MALT1 34 35
  • 88.43 (n)
(Bos Taurus)
Mammalia MALT1 34 35
  • 86.37 (n)
(Mus musculus)
Mammalia Malt1 34 16 35
  • 86.15 (n)
(Rattus norvegicus)
Mammalia Malt1 34
  • 84.91 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 84 (a)
-- 35
  • 73 (a)
-- 35
  • 64 (a)
(Monodelphis domestica)
Mammalia MALT1 35
  • 72 (a)
(Gallus gallus)
Aves LOC426852 34
  • 71.73 (n)
MALT1 35
  • 63 (a)
(Anolis carolinensis)
Reptilia MALT1 35
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia malt1 34
  • 64.1 (n)
(Danio rerio)
Actinopterygii malt1b 34 35
  • 61.1 (n)
malt1 34
(Caenorhabditis elegans)
Secernentea F22D3.6 36 34 35
  • 46.9 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1584 35
  • 24 (a)
Species where no ortholog for MALT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MALT1 Gene

Gene Tree for MALT1 (if available)
Gene Tree for MALT1 (if available)

Paralogs for MALT1 Gene

No data available for Paralogs for MALT1 Gene

Variants for MALT1 Gene

Sequence variations from dbSNP and Humsavar for MALT1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs398123058 Immunodeficiency 12 (IMD12) [MIM:615468], Pathogenic 58,681,226(+) CCCCA(G/T)CCTGT intron-variant, nc-transcript-variant, reference, missense
rs587777337 Pathogenic 58,742,000(+) ACAGT(C/G)GGCCA nc-transcript-variant, reference, missense
rs786200953 Pathogenic 58,723,046(+) TTCAA(A/G)GCGAA splice-acceptor-variant
rs786200954 Pathogenic 58,723,089(+) ATTAC(-/C)GGGAG nc-transcript-variant, reference, frameshift-variant
rs10164262 -- 58,698,352(+) GAGCT(A/G)TCGCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MALT1 Gene

Variant ID Type Subtype PubMed ID
esv2447858 CNV deletion 19546169
esv3583096 CNV loss 25503493
esv3583097 CNV loss 25503493
nsv1126485 CNV deletion 24896259
nsv519742 CNV loss 19592680
nsv524760 CNV loss 19592680
nsv577050 CNV loss 21841781
nsv819829 CNV loss 19587683
nsv820257 CNV loss 19587683

Variation tolerance for MALT1 Gene

Residual Variation Intolerance Score: 42.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MALT1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MALT1 Gene

Disorders for MALT1 Gene

MalaCards: The human disease database

(22) MalaCards diseases for MALT1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency 12
  • imd12
lymphoma, malt, somatic
  • lymphoma, mucosa-associated lymphoid type
b-cell lymphoma of mucosa-associated lymphoid tissue
  • lymphoid cancer
b-cell lymphomas
  • b-cell lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search MALT1 in MalaCards View complete list of genes associated with diseases


  • Immunodeficiency 12 (IMD12) [MIM:615468]: A primary immunodeficiency characterized by onset in infancy of recurrent bacterial and candidal infections resulting in bronchiectasis and growth delay. Manifestations include mastoiditis, aphthous ulcers, cheilitis, gingivitis, esophagitis, gastritis, duodenitis, and meningitis. Levels of absolute lymphocytes and serum immunoglobulins are normal, but specific antibody titers are low despite immunization, and T-cells show impaired proliferative responses to mitogens. {ECO:0000269 PubMed:23727036}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma. {ECO:0000269 PubMed:10339464, ECO:0000269 PubMed:10523859, ECO:0000269 PubMed:10702396, ECO:0000269 PubMed:11090634}.

Relevant External Links for MALT1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MALT1: view

No data available for Genatlas for MALT1 Gene

Publications for MALT1 Gene

  1. Identification of paracaspases and metacaspases. Two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. (PMID: 11090634) Uren A.G. … Dixit V.M. (Mol. Cell 2000) 2 3 4 22 64
  2. The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas. (PMID: 10339464) Dierlamm J. … Marynen P. (Blood 1999) 2 3 4 22 64
  3. A novel gene, MALT1 at 18q21, is involved in t(11;18)(q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. (PMID: 10523859) Akagi T. … Seto M. (Oncogene 1999) 2 3 4 22 64
  4. Germline variations of the MALT1 gene as risk factors in the development of primary gastric B-cell lymphoma. (PMID: 19394813) Hellmig S. … Schreiber S. (Eur. J. Cancer 2009) 3 22 46 64
  5. MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10. (PMID: 16123224) Nakagawa M. … Seto M. (Blood 2005) 3 4 22 64

Products for MALT1 Gene

Sources for MALT1 Gene

Loading form....