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MALT1 Gene

protein-coding GIFtS: 66

GC18P054489

mucosa associated lymphoid tissue lymphoma translocation gene 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MLT)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DKFZp434L132 ^²
EC 3.4.22.- ^³
MLT ^², ³, ⁵
MLT1 ^²
Paracaspase ^³
paracaspase ^²

Descriptions
MALT associated translocation ^²
MALT lymphoma-associated translocation ^³
MALT-lymphoma associated translocation ^²
caspase-like protein ^²
mucosa associated lymphoid tissue lymphoma translocation gene 1 ^²
mucosa associated lymphoid tissue lymphoma translocation protein 1 ^²

External Ids
HGNC: 6819¹
Entrez Gene: 10892²
UniProtKB: Q9UDY8³
Ensembl: ENSG00000172175⁷

Search outside databases for aliases for MALT1 gene

Previous GC identifers: GC18P056267 GC18P056123 GC18P054487

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for MALT1:

This gene has been found to be recurrently rearranged in chromosomal translocation with two other

genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and

immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein

encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript

variants encoding different isoforms have been described for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: MALT1_HUMAN, Q9UDY8

Function: Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10.

Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has

ubiquitin ligase activity. MALT1-dependent BCL-10 cleavage plays an important role in T-cell

antigen receptor-induced integrin adhesion

Gene Wiki entry for MALT1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the MALT1 gene

Entrez Gene cytogenetic band: 18q21 Ensembl cytogenetic band: 18q21.32 HGNC cytogenetic band: 18q21

MALT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P054489: (about GC identifiers)

Start:	54,489,598 bp from pter
End:	54,568,350 bp from pter
Size:	78,753 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000018.8 NT_025028.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: MALT1_HUMAN, Q9UDY8 (See protein sequence)

Recommended Name: Mucosa-associated lymphoid tissue lymphoma translocation protein 1

Size: 824 amino acids; 92272 Da

Subunit: Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6

Subcellular location: Cytoplasm, perinuclear region. Nucleus. Note=Shuttles between the nucleus and

cytoplasm. Found in perinuclear structures together with BCL10

PDB structure from and Proteopedia :

2G7R (3D)

3BFO (3D)

Secondary accessions: Q9NTB7 Q9ULX4

Alternative splicing: 2 isoforms: Q9UDY8-1 Q9UDY8-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_006776.1 NP_776216.1

ENSEMBL proteins:

ENSP00000319279 ENSP00000304161

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (MALT1)
	Human Recombinant Proteins from Abnova (MALT1)

OriGene Purified Recombinant Human Protein: MALT1

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	16123224
GO:0005737	cytoplasm	IDA	16123224
GO:0005829	cytosol	EXP	15125833
GO:0032449	CBM complex	NAS	15125833

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Antibodies for MALT1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of MALT1
	Sigma-Aldrich Antibodies for MALT1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for MALT1
	Antibodies from Abcam (MALT1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (MALT1)
	Novus Biologicals Antibodies for MALT1

Assays for MALT1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q9UDY8

ProtoNet protein and cluster: Q9UDY8

2 Blocks protein families:

IPB001309 Caspase-1

IPB003598 Immunoglobulin C-2 type

UniProtKB/Swiss-Prot: MALT1_HUMAN, Q9UDY8

Similarity: Belongs to the peptidase C14B family

Similarity: Contains 1 death domain

Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MALT1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MALT1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_173844

Applied Biosystems Silencer® siRNAs for MALT1

Sigma-Aldrich siRNA for MALT1

Sigma-Aldrich shRNA Panels and shRNA for MALT1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for MALT1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_006785
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_006785
untagged cDNA clones in CMV expression vector (see all 2): NM_006785

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006785

UniProtKB/Swiss-Prot: MALT1_HUMAN, Q9UDY8

Function: Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10.

Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has

ubiquitin ligase activity. MALT1-dependent BCL-10 cleavage plays an important role in T-cell

antigen receptor-induced integrin adhesion

Enzyme Number (IUBMB): EC 3.4.22.-

Genatlas biochemistry entry for MALT1:

mucosa associated lymphoid tissue rearranged with API2 in the t(11;18)(q21;q21) in extranodal

marginal zone B-cell lymphomas,in low-grade B cell lymphoma of mucosa associated lymphoid tissue

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Malt1):

hematopoietic system

immune system

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004197	cysteine-type endopeptidase activity	NAS	11090634
GO:0004842	ubiquitin-protein ligase activity	IDA	14695475 15125833
GO:0004871	signal transducer activity	IMP	12761501
GO:0008233	peptidase activity	IEA	--
GO:0019209	contributes to kinase activator activity	IMP	15125833

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for MALT1 (Your Favorite Gene powered by Ingenuity)

B Cell Receptor Signaling
CD28 Signaling in T Helper Cells
NF-&kappa
T Cell Receptor Signaling

GeneDecks MALT1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for MALT1

5/39 Interacting proteins for MALT1 (ENSP00000319279³ Q9UDY8^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 39 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	P62988²	STRING (score=.969) MINT-6177541 MINT-6177742 MINT-6177655 MINT-6177677 MINT-6177702
TRAF6	Q9Y4K3²	STRING (score=.999) MINT-6177590 MINT-6177582 MINT-6177625
BCL10	O95999²	STRING (score=.999) MINT-6177529 MINT-6177625
CARD11	Q9BXL7²	STRING (score=.999) MINT-6177529 MINT-6177640
IKBKG	Q9Y6K9²	STRING (score=.998) MINT-6177604 MINT-6177554

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5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002726	positive regulation of T cell cytokine production	IMP	15125833
GO:0006508	proteolysis	IEA	--
GO:0006916	anti-apoptosis	NAS	11090634 11096264
GO:0006952	defense response	NAS	10523859
GO:0007250	activation of NF-kappaB-inducing kinase activity	IMP	15125833

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for MALT1
2 Novoseek chemical compound relationships for MALT1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
guanylate	13.14	2	15598810 (1)
lipid	0.00	6	14754896 (2), 15598810 (1), 15541657 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (MALT1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (MALT1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_173844

Sigma-Aldrich siRNA for MALT1

Sigma-Aldrich shRNA Panels and shRNA for MALT1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006785 NM_173844

REFSEQ mRNAs for MALT1 gene (2 alternative transcripts):

NM_006785.2 NM_173844.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006785 NM_173844

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_006785
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_006785
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_006785

Additional cDNA sequence:

AB026118.1 AF070528.1 AF130356.2 AF316597.1 AK024859.1 AK291386.1 AL137399.1 BC030143.2

8 DOTS entries:

DT.95378868 DT.409881 DT.95378865 DT.455907 DT.100022175 DT.102830301 DT.408942 DT.99949626

24/132 AceView cDNA sequences (see all 132 ):

AA781565 AW292944 AA767805 AL599422 AK092004 BU164882 BQ006885 BQ130948

CA447544 NM_173844 BM724275 AA281201 BM680409 AI139811 AL137399 AA687848

AF316597 BQ023987 BU753389 BC030143 AB026118 AA706088 CB129946 NM_006785

highest scoring ESTs for MALT1:

AB026118 AF070528 AA283928 AA402144 AF316597 AI492489 AI685199 AI768778 AI824040 AK024859

Unigene Cluster for MALT1:

Mucosa associated lymphoid tissue lymphoma translocation gene 1

Hs.601217 [show with all ESTs]

Unigene Representative Sequence: NM_006785

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000348428 ENST00000345724

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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MALT1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for MALT1

¹ / ² / ³

9 probe-sets matching MALT1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38575_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.96	AF070528	1.00	1.00	1.00	1
32350_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.00	AB026118	1.00	1.00	1.00	1
69112_r_at*²^{, 3}	U95-E	1	--	--	0.43	1.05	AA034037	0.40	1.00	0.76	1
210017_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF070528	1.00	1.00	1.00	1
208309_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006785	0.60	1.00	0.82	1
210018_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AB026118	1.00	1.00	1.00	1
210017_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208309_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210018_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks MALT1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGATAGACT

SOURCE GeneReport for Unigene cluster: Hs.601217
Expression variation in blood from EXPOLDB for MALT1
UniProtKB/Swiss-Prot: MALT1_HUMAN, Q9UDY8
Tissue specificity: Highly expressed in peripheral blood mononuclear cells. Detected at lower
levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for MALT1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MALT1¹	--	mucosa associated lymphoid tissue lymphoma translocation more	88.11(n) 92.87(a)	476188 XM_533392.2 XP_533392.2
chimpanzee (Pan troglodytes)	MALT1¹	--	mucosa associated lymphoid tissue lymphoma translocation more	99.72(n) 99.51(a)	468549 XM_523938.2 XP_523938.2
cow (Bos taurus)	MALT1¹	--	mucosa associated lymphoid tissue lymphoma translocation more	86.15(n) 90.1(a)	504994 XM_581210.3 XP_581210.3
rat (Rattus norvegicus)	Malt1¹	--	mucosa associated lymphoid tissue lymphoma translocation more	84.91(n) 88.81(a)	307366 XM_225927.4 XP_225927.4
mouse (Mus musculus)	Malt1^{1, 5}	18⁵	mucosa associated lymphoid tissue lymphoma translocation more^{1, 5}	86.15(n)¹ 88.29(a)¹	240354¹ NM_172833.2¹ NP_766421.1¹ AK041919⁵ AK045200⁵ (see all 12)

About this table Species with no ortholog for MALT1

ENSEMBL Gene Tree for MALT1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/410 NCBI SNPs in MALT1 are shown (see all 410 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 126)

AB	SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1059442^1,2	C,F,H,O	54567673(+)	`TGCCAT/CTTCCA`	2	--	ut3¹		5		MN EU EA WA	602
--	rs2319974^1,2	A,C,F,H	54567449(-)	`ACATAT/CACACA`	2	--	ut3¹ ese³		5		MN EU EA WA	604
--	rs6567007^1,2	A,C,F	54568801(+)	`ttctgG/Atcaac`	2	--	ng3¹		3		NA	140
--	rs7236423^1,2	A,C	54566599(+)	`ATATAG/TATATA`	2	--	ut3¹ ese³		0	--	--	--	--
	rs7231745^1,2	F,H	54566546(+)	`CCTGAC/TAGGTT`	2	--	ut3¹ ese³		4		EU EA WA	416
	rs9947866^1,2	F,H	54566255(+)	`TTGTGA/TATTGG`	2	--	ut3¹		4		EU EA WA	420
	rs35533328^1,2	C,F	54563887(+)	`TAGATA/GTTGAT`	2	I/V	mis¹		5		NA EU EA WA	490
--	rs11665219^1,2	C	54568793(+)	`ccataC/Tatttc`	2	--	ng3¹		0	--	--	--	--
	rs12455750^1,2	H	54514679(+)	`ATCAGT/GGGTTC`	2	G/W	mis¹ ese³		4		EU EA WA	416
--	rs11541813^1,2	H	54499435(+)	`AAGCCC/TCAGCC`	2	P/L	mis¹ ese³		4		EU EA WA	404

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HapMap Linkage Disequilibrium images for MALT1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604860

UniProtKB/Swiss-Prot: MALT1_HUMAN, Q9UDY8

A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated

lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is

found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma

9 Novoseek disease relationships for MALT1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
malt lymphoma	93.54	88	15682443 (8), 14760068 (4), 10523859 (3), 11090634 (3) (see all 40)
lymphoma b-cell	80.12	27	18367485 (4), 14652825 (3), 11066071 (2), 16804917 (2) (see all 16)
lymphoma	69.98	12	11066071 (1), 12560219 (1), 10702396 (1), 17199743 (1) (see all 9)
chromosomal aberrations	61.74	10	19080537 (2), 14760068 (2), 16194887 (1), 10702396 (1) (see all 7)
trisomy	56.24	10	15047736 (3), 18974375 (1), 17222250 (1), 18234275 (1) (see all 5)
lymphoma non-hodgkins	41.99	3	12560219 (2), 15598810 (1)
tumors	13.73	5	12647364 (1), 14754896 (1), 17607378 (1)
necrosis	0.00	1	14754896 (1)
metastasis	0.00	1	15067352 (1)

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Human Genome Epidemiology Navigator: MALT1 (1 document)

(Possibly Related Articles in Doctor's Guide)
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UEGW: Chromosome Translocation Found That Might Help Identify at Risk Patients With Gastric Lymphoma

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/135 PubMed articles for MALT1 gene (see all 135 ):

The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas. (PubMed id 10339464)^{1, 2, 3, 4} Dierlamm J.... Marynen P. (1999)
A novel gene, MALT1 at 18q21, is involved in t(11;18)(q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. (PubMed id 10523859)^{1, 2, 3, 4} Akagi T.... Seto M. (1999)
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. (PubMed id 15125833)^{1, 3, 4} Sun L.... Chen Z.J. (2004)
MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10. (PubMed id 16123224)^{1, 3, 4} Nakagawa M.... Seto M. (2005)
Identification of paracaspases and metacaspases. Two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. (PubMed id 11090634)^{1, 3, 4} Uren A.G.... Dixit V.M. (2000)
Bcl10 and MALT1, independent targets of chromosomal translocation in MALT lymphoma, cooperate in a novel NF-kappa B signaling pathway. (PubMed id 11262391)^{1, 3, 4} Lucas P.C.... Nunez G. (2001)
API2-MALT1 chimeric transcripts involved in mucosa-associated lymphoid tissue type lymphoma predict heterogeneous products. (PubMed id 10702396)^{1, 3, 4} Motegi M.... Seto M. (2000)
Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. (PubMed id 14695475)^{3, 4} Zhou H.... Dixit V.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
API1-MALT1-MLT is involved in mucosa-associated lymphoid tissue lymphoma with t(11;18).(q21;q21). (PubMed id 10610122)^{3, 4} Suzuki H.... Seto M. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 10892	HGNC: 6819	AceView: MALT1	Ensembl:ENSG00000172175	euGenes: HUgn10892
ECgene: MALT1	H-InvDB: MALT1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for MALT1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for MALT1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for MALT1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for MALT1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

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Antibodies & Assays for MALT1

	Recombinant Proteins (MALT1)
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	Tagged/untagged cDNA clones
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	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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Antibodies for MALT1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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MALT1 Gene at Home site.
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MALT1 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for MALT1

Summaries
for MALT1

Genomic Location
for MALT1

Proteins
for MALT1

Protein Domains/
Families
for MALT1

Gene Function
for MALT1

Pathways & Interactions
for MALT1

Drugs & Compounds
for MALT1

Transcripts
for MALT1

Expression
for MALT1

Orthologs
for MALT1

Paralogs
for MALT1

SNPs/Variants
for MALT1

Disorders & Mutations
for MALT1

Medical News
for MALT1

Publications
for MALT1

Search for MALT1

Genome Databases showing MALT1

Other Databases showing MALT1

Specialized Databases showing MALT1

Licensable Technologies
for MALT1

Services
for MALT1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

MALT1 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor MALT1

Summariesfor MALT1

Genomic Locationfor MALT1

Proteinsfor MALT1

Protein Domains/Familiesfor MALT1

Gene Functionfor MALT1

Pathways & Interactionsfor MALT1

Drugs & Compoundsfor MALT1

Transcriptsfor MALT1

Expression for MALT1

Orthologsfor MALT1

Paralogsfor MALT1

SNPs/Variantsfor MALT1

Disorders & Mutationsfor MALT1

Medical Newsfor MALT1

Publicationsfor MALT1

Search for MALT1

Genome Databases showing MALT1

Other Databases showing MALT1

Specialized Databases showing MALT1

Licensable Technologiesfor MALT1

Servicesfor MALT1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for MALT1

Summaries
for MALT1

Genomic Location
for MALT1

Proteins
for MALT1

Protein Domains/
Families
for MALT1

Gene Function
for MALT1

Pathways & Interactions
for MALT1

Drugs & Compounds
for MALT1

Transcripts
for MALT1

Expression
for MALT1

Orthologs
for MALT1

Paralogs
for MALT1

SNPs/Variants
for MALT1

Disorders & Mutations
for MALT1

Medical News
for MALT1

Publications
for MALT1

Licensable Technologies
for MALT1

Services
for MALT1